担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：MDPI AG  

Tungiasis, caused by the sand flea Tunga penetrans, results in itching and pain. Effective treatments, such as dimeticones, are often unaffordable. A 3% phenothrin lotion has shown safety and efficacy in Kenyan trials. This study compared the cure rate and safety of 3% phenothrin lotion (as the intervention) and 0.05% potassium permanganate (KMnO4; as the standard-care comparator) over 14 days. This parallel-group, three-arm, non-blinded, randomised comparative trial was conducted in Vihiga County, Kenya. Participants aged ≥2 years with ≥1 viable flea on each foot were allocated (2:1:1) to KMnO4, single-dose 3% phenothrin, or two-dose 3% phenothrin groups. Overall, 415 fleas from 79 participants were followed up to day 14 (KMnO4, 213; single-dose, 129; two-dose, 73). On days 4 and 7, the single-dose phenothrin showed significantly higher cure rates (11.6% and 21.7%) than KMnO4 (0.9% and 11.7%) (p < 0.001 and p = 0.013). The differences diminished by days 10 and 14 because of spontaneous flea death. The cure rate of the two-dose group on day-7 (8.2%) was lower than that of the single-dose group. Single-dose 3% phenothrin improved early cure rates compared to KMnO4, but not by days 10–14; two-dose phenothrin showed no benefit compared with single dose from day 7 onwards.

DOI： 10.3390/tropicalmed11020047

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担当区分：筆頭著者,　責任著者  

in press

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掲載種別：研究論文（学術雑誌）   出版者・発行元：JMIR Publications Inc.  

Background

The impacts of climate change, such as air pollution and abnormal weather, are becoming more apparent and threatening to human health. In response, the concept of planetary health was proposed in 2015 based on the recognition that human and earth health are closely related and that the general public needs to improve the health and sustainability of the ecosystems through a comprehensive approach. As economic development and human longevity progress, the burden on the earth’s environment will increase; however, systematic methods for education and planetary health practices have not yet been established.

Objective

This study aims to clarify the current status and challenges of planetary health–related education. Specifically, it seeks to identify and analyze both existing educational programs that have already been implemented and evaluated, as well as those that have not yet been systematically assessed, providing insights for future curriculum development.

Methods

A scoping review based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines will be conducted using the Population-Concept-Context framework. Without a defined target period, original papers and conference proceedings published in PubMed, CINAHL, EMBASE, Web of Science, Scopus, Google Scholar, and the Cochrane Central Register of Controlled Trials will be searched, and the findings will be disseminated through peer-reviewed publications and conference presentations. Studies with descriptions of planetary health education are included, while review papers and studies published in languages other than English or Japanese are excluded.

Results

As of August 2025, 28 studies had been selected. Data collection was carried out between May 2024 and July 2025. Preliminary data analysis will be conducted again in September 2025. The results are currently being prepared for publication and are expected to be published by October 2025.

Conclusions

This study will identify the current status and challenges of planetary health education. The findings will contribute to developing future curricula that promote ecosystem health and sustainability.

International Registered Report Identifier (IRRID)

DERR1-10.2196/70910

DOI： 10.2196/70910

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担当区分：筆頭著者,　責任著者  

DOI： 10.1186/s41182-024-00639-8

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担当区分：筆頭著者,　責任著者   掲載種別：研究論文（学術雑誌）   出版者・発行元：Public Library of Science (PLoS)  

Background

Tungiasis is a cutaneous parasitosis caused by the female flea Tunga penetrans. Two-component dimeticone (NYDA) is the only treatment for tungiasis recommended by the World Health Organization; however, this topical drug is not available in Kenya. In Western Kenya, sodium carbonate is commonly used in the treatment of tungiasis. This study evaluated the 7-day cure rates for tungiasis by comparing sodium carbonate and NYDA treatments in Homa Bay County, Kenya.

Methodology/Principal findings

This was a randomized, observer-blinded, parallel-treatment cohort trial. Twenty-three eligible children with 126 flea infections were matched and randomized. All participants received both treatments, with one treatment on each foot. We recorded all health conditions/information, including inflammation scores and adverse events. Observations were performed on days 3, 5, and 7 using a digital microscope to confirm dead or live fleas based on the viability signs. Twenty-three children aged 3–13 years were analyzed. The proportion of dead fleas on day 7 was higher after NYDA treatment than after 5% sodium carbonate treatment (87% versus 64%, respectively, P = 0.01) NYDA. Median survival was 5 days for both treatments; NYDA had significantly higher trend of flea non-viability rate than 5% sodium carbonate (P<0.01). There were no significant differences in the inflammation score or pain/itchiness between the two treatments. On the last day, 14 children indicated their preference for NYDA in future treatment of tungiasis, whereas nine children preferred the 5% sodium carbonate solution.

Conclusions/Significance

NYDA was significantly more effective than 5% sodium carbonate for tungiasis treatment. Both treatments were safe but the children preferred NYDA more. Future studies with more participants and an extended observation period are warranted to confirm our findings. The findings suggest that NYDA should be made more available in tungiasis endemic area.

Trial registration

UMIN-CTR; UMIN 000044320

DOI： 10.1371/journal.pntd.0012341

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J-GLOBAL

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会議種別：口頭発表（一般）  

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会議種別：口頭発表（一般）  

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会議種別：口頭発表（一般）  

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会議種別：口頭発表（一般）  

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会議種別：ポスター発表  

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