2025/07/01 更新

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写真a

オオイ ヤスフミ
大井 康史
Yasufumi Oi
所属
医学研究科 医科学専攻 救急医学 准教授
医学部 医学科
職名
准教授
プロフィール

Capillary Refill Timeを定量化したデバイスの有用性の検討

外部リンク

学位

  • 博士(医学) ( 横浜市立大学 )

研究キーワード

  • 乳酸値

  • QCRT

  • 敗血症

研究分野

  • ライフサイエンス / 救急医学

経歴

  • 横浜市立大学附属病院   救急科   准教授

    2024年4月 - 現在

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    国名:日本国

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論文

  • Enhancing clinical reasoning skills in medical students through team-based learning: a mixed-methods study. 国際誌

    Kosuke Ishizuka, Kiyoshi Shikino, Naoko Takada, Yohei Sakai, Yasushi Ototake, Takashi Kobayashi, Tetsuhiko Inoue, Ryosuke Jikuya, Yuri Iwata, Kenichi Nishimura, Ryusuke Yoshimi, Yasufumi Oi, Yuko Watanabe, Yu Togashi, Fumihiro Ogawa, Daisuke Sano, Takeshi Asami, Yuichi Imai, Ichiro Takeuchi, Kengo Funakoshi, Mitsuyasu Ohta, Masahiko Inamori, Akihiko Kusakabe

    BMC medical education   25 ( 1 )   221 - 221   2025年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Clinical reasoning skills are essential competencies for medical students; therefore, effective, evidence-informed teaching methodologies are needed worldwide. This study investigated the benefits of team-based learning (TBL) for developing the skills in medical students. METHOD: A mixed-methods sequential explanatory design was used to investigate the effectiveness of TBL for medical students acquiring clinical reasoning skills. The study participants comprised 92 fourth-year medical students at Yokohama City University School of Medicine, participating in TBL sessions that covered 10 major clinical symptoms identified in the core curriculum. Each session lasted 240 min. Before and after the educational intervention, student performance was measured using the script concordance test (SCT) on a 30-point scale, and self-assessed clinical reasoning competency was measured on a 7-point Likert scale. The SCT included pre-tests and post-tests of 30 questions each, with students randomly assigned to one of two test sets. Following the quantitative evaluation, a qualitative content analysis was conducted to explore the advantages of TBL for learning clinical reasoning skills. The analytic categories were set according to the six levels of Fink's taxonomy of significant learning. RESULT: Student performance improved significantly after the educational intervention (A test: 16.5 ± 4.4 to 18.7 ± 4.5, p = 0.019; B test: 18.1 ± 3.7 to 19.8 ± 4.4, p = 0.028). After the educational intervention, self-assessed clinical reasoning competency was significantly higher in "recalling appropriate physical examination and tests on clinical hypothesis generation," "recalling appropriate differential diagnosis from patient's chief complaint," "verbalizing points that fit/don't fit the recalled differential diagnosis appropriately," "verbalizing and reflecting appropriately on own mistakes," "selecting keywords from the whole aspect of the patient," and "practicing the appropriate clinical reasoning process" (all p < 0.001). The content analysis extracted 23 subcategories and 233 codes of the advantages of TBL for learning clinical reasoning skills, covering all six levels of Fink's taxonomy of significant learning: Foundational knowledge (7 codes); Application (40 codes); Integration (69 codes); Human dimension (89 codes); Caring (8 codes); and Learning how to learn (20 codes). CONCLUSION: This study demonstrates that TBL supports the acquisition of critical clinical reasoning skills among medical students.

    DOI: 10.1186/s12909-025-06784-w

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  • A Screening Tool to Predict Sepsis in Patients With Suspected Infection in the Emergency Department. 国際誌

    Yasufumi Oi, Fumihiro Ogawa, Hiroshi Honzawa, Takeru Abe, Shouhei Imaki, Ichiro Takeuchi

    Cureus   17 ( 2 )   e78728   2025年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and objective Sepsis is a life-threatening condition associated with high morbidity and mortality, and hence early recognition and treatment are crucial. The 2016 Sepsis-3 guidelines introduced the quick Sequential Organ Failure Assessment (qSOFA), but its low sensitivity limits early detection. The 2021 Surviving Sepsis Campaign Guidelines (SSCG) discourage relying solely on qSOFA and recommend additional tools such as the systemic inflammatory response syndrome (SIRS) score, the National Early Warning Score (NEWS), and the Modified Early Warning Score (MEWS) along with lactate measurement. This study assessed whether combining qSOFA with quantitative capillary refill time (Q-CRT) or lactate levels enhances early sepsis diagnosis in emergency departments. Methods This retrospective, multi-facility observational study was conducted at two hospitals in Yokohama, Japan. Patients with suspected infections who underwent Q-CRT measurement were included. Q-CRT was measured using a pulse oximeter-based device that records the time taken for blood flow to return to 90% after compression. Receiver operating characteristic (ROC) curves determined the area under the curve (AUC), sensitivity, and specificity. Statistical significance was set at p<0.05. Results Of the 357 patients who underwent Q-CRT measurement, 75 (21%) were suspected of having an infection, with 48 (64%) classified as having sepsis with organ dysfunction. Patients in the sepsis group had higher age, heart rate, lactate level, creatinine level, NEWS, MEWS, and Sequential Organ Failure Assessment (SOFA) scores compared to those without organ dysfunction. Among individual tools, the qSOFA, NEWS, and MEWS scores showed high AUCs (>0.8), while Q-CRT and lactate levels demonstrated moderate predictive accuracy with AUCs exceeding 0.7. The SIRS score had the lowest predictive ability, with an AUC of approximately 0.6. Combining qSOFA with Q-CRT or lactate levels significantly improved sensitivity and specificity. The qSOFA+Q-CRT combination resulted in an AUC of 0.821, sensitivity of 83.3%, and specificity of 81.4%, while the qSOFA+lactate combination yielded an AUC of 0.844, sensitivity of 87.5%, and specificity of 81.4%. These combinations exceeded 80% in both sensitivity and specificity, unlike the SIRS-based combinations, which showed limited improvement and specificity below 40%. While the qSOFA score alone demonstrated limited sensitivity, combining it with Q-CRT or lactate levels enhanced its predictive performance for early sepsis detection. This approach improved sensitivity without compromising specificity. The increase in sensitivity and specificity is likely due to Q-CRT and lactate identifying sepsis cases not detected by qSOFA, thereby making the combined approach more reliable for clinical use. Lactate levels are well-established markers associated with sepsis severity, and Q-CRT offers a non-invasive means of assessing peripheral perfusion. Conclusions Combining qSOFA with Q-CRT or lactate levels significantly improves early sepsis detection by enhancing both sensitivity and specificity. These combinations offer superior diagnostic accuracy compared to standalone tools, supporting their potential integration into clinical protocols for better patient outcomes. Further prospective studies are needed to validate these findings across diverse clinical settings.

    DOI: 10.7759/cureus.78728

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  • 致死量のアセトアミノフェン中毒による急性肝不全に対して血漿交換を行い改善した一例

    十河 梓, 本澤 大志, 小川 史洋, 大井 康史, 貞広 智瑛梨, 水上 紗織里, 竹内 一郎

    神奈川医学会雑誌   51 ( 1 )   122 - 122   2024年1月

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    記述言語:日本語   出版者・発行元:(公社)神奈川県医師会  

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  • 致死量のアセトアミノフェン中毒による急性肝不全に対して血漿交換を行い改善した一例

    十河 梓, 本澤 大志, 小川 史洋, 大井 康史, 貞広 智瑛梨, 水上 紗織里, 竹内 一郎

    神奈川医学会雑誌   51 ( 1 )   122 - 122   2024年1月

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    記述言語:日本語   出版者・発行元:(公社)神奈川県医師会  

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  • 敗血症を予測するスクリーニングツールの検討

    大井 康史, 小川 史洋, 本澤 大志, 四宮 祥恵, 水上 紗緒里, 貞広 智瑛梨, 安部 猛, 竹内 一郎

    日本救急医学会雑誌   34 ( 12 )   698 - 698   2023年12月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • ECPRを施行された院外心停止患者に対する予防的下肢送血と退院時生存との関連 SAVE-J2 studyの二次解析

    本澤 大志, 谷口 隼人, 安部 猛, 大井 康史, 小川 史洋, 竹内 一郎

    日本救急医学会雑誌   34 ( 12 )   705 - 705   2023年12月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • ECPRを施行された院外心停止患者に対する予防的下肢送血と退院時生存との関連 SAVE-J2 studyの二次解析

    本澤 大志, 谷口 隼人, 安部 猛, 大井 康史, 小川 史洋, 竹内 一郎

    日本救急医学会雑誌   34 ( 12 )   705 - 705   2023年12月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • 重症COVID-19への戦いはまだ続く 呼吸管理編 CTスコアを用いた重症COVID肺炎患者の予後予測の検討

    大井 康史, 小川 史洋, 山城 恒雄, 松下 彰一郎, 小栗 絢子, 歌田 州佑, 三澤 菜穂, 本澤 大志, 安部 猛, 竹内 一郎

    日本集中治療医学会雑誌   30 ( Suppl.1 )   S294 - S294   2023年6月

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    記述言語:日本語   出版者・発行元:(一社)日本集中治療医学会  

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  • Association of obesity paradox with prognosis of veno-venous-extracorporeal membrane oxygenation in patients with coronavirus disease 2019. 国際誌

    Hiroshi Honzawa, Hayato Taniguchi, Fumihiro Ogawa, Yasufumi Oi, Takeru Abe, Ichiro Takeuchi

    Acute medicine & surgery   10 ( 1 )   e871   2023年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: Although the obesity paradox is known for various diseases, including cancer and acute respiratory distress syndrome, little is known about veno-venous extracorporeal membrane oxygenation (VV-ECMO) in patients with coronavirus disease 2019 (COVID-19). In this study, we aimed to investigate the association between body mass index (BMI) and prognosis in critical patients with COVID-19 requiring VV-ECMO. METHODS: We conducted a retrospective observational single-center study at Yokohama City University Civic General Medical Center between March 2020 and October 2021. Participants were patients with COVID-19 who required VV-ECMO. They were classified into two groups: BMI ≤30 kg/m2 and >30 kg/m2. RESULTS: In total, 23 patients were included in the analysis, with a median BMI of 28.7 kg/m2. Overall, 22 patients were successfully weaned from the ECMO. When comparing the two groups, there was a trend toward fewer days from onset to ECMO induction in the BMI >30 kg/m2 group. Moreover, the two groups had a similar prognosis. There were no statistically significant differences in the number of days from onset to hospitalization or the duration of ECMO induction between the groups. CONCLUSION: VV-ECMO induction for patients with COVID-19 may lead to earlier indications in patients with BMI >30 kg/m2 than in those with BMI ≤30 kg/m2.

    DOI: 10.1002/ams2.871

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  • COVID-19患者におけるECMO導入とobesity paradoxの関連についての検討

    本澤 大志, 谷口 隼人, 大井 康史, 武田 知晃, 大田 聡一, 竹内 一郎

    日本救急医学会関東地方会雑誌   43 ( 1 )   P - 57   2022年2月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • Peripheral venous lactate levels substitute arterial lactate levels in the emergency department. 国際誌

    Yasufumi Oi, Kosuke Mori, Hidehiro Yamagata, Ayako Nogaki, Tomoaki Takeda, Chikara Watanabe, Yusuke Sakaguchi, Fumihiro Ogawa, Takeru Abe, Shouhei Imaki, Ichiro Takeuchi

    International journal of emergency medicine   15 ( 1 )   7 - 7   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Arterial lactate (AL) level is an important predictor of patient prognosis. AL and peripheral venous lactate (PVL) in blood gas analysis have a low concordance rate, and PVL cannot be used as a substitute for AL. However, if the AL range can be predicted from PVL, PVL may be an alternative method for predicting patient prognosis, and the risk of arterial puncture complications with AL may be reduced. This could be a safe and rapid test method. METHODS: This was a retrospective observational study of 125 cases in which blood gas analysis was performed on both arterial and venous blood with an infectious disease in an emergency department. Spearman's rank correlation coefficient (r) and Bland-Altman analyses were performed. Sensitivity, specificity, and area under the curve (AUC) were calculated for PVL to predict AL < 2 mmol/L or < 4 mmol/L. RESULTS: The median [interquartile range] AL and PVL were 1.82 [1.25-2.46] vs. 2.08 [1.57-3.28], respectively, r was 0.93 (p < 0.0001), and a strong correlation was observed; however, Bland-Altman analysis showed disagreement. When AL < 2 mmol/L was used as the outcome, AUC was 0.970, the PVL cutoff value was 2.55 mmol/L, sensitivity was 85.71%, and specificity was 96.05%. If PVL < 2 mmol/L was the outcome, the sensitivity for AL < 2mmol/L was 100%, and for PVL levels ≥ 3 mmol/L, the specificity was 100%. When AL < 4 mmol/L was used as the outcome, AUC was 0.967, the PVL cutoff value was 3.4 mmol/L, sensitivity was 100%, and specificity was 85.84%. When PVL < 3.5 mmol/L was the outcome, the sensitivity for AL < 4 mmol/L was 100%, and for PVL levels ≥ 4 mmol/L, the specificity was 93.81%. CONCLUSIONS: This study revealed that PVL and AL levels in the same critically ill patients did not perfectly agree with each other but were strongly correlated. Furthermore, the high accuracy for predicting AL ranges from PVL levels explains why PVL levels could be used as a substitute for AL level ranges.

    DOI: 10.1186/s12245-022-00410-y

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  • 胸痛により救急搬送された再発性多発軟骨炎の一例

    鷲見 健翔, 菊池 優志, 武田 知晃, 三澤 菜穂, 本澤 大志, 小川 史洋, 大井 康史, 竹内 一郎

    神奈川医学会雑誌   49 ( 1 )   96 - 96   2022年1月

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    記述言語:日本語   出版者・発行元:(公社)神奈川県医師会  

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  • Severity predictors of COVID-19 in SARS-CoV-2 variant, delta and omicron period; single center study. 国際誌

    Fumihiro Ogawa, Yasufumi Oi, Hiroshi Honzawa, Naho Misawa, Tomoaki Takeda, Yushi Kikuchi, Ryosuke Fukui, Katsushi Tanaka, Daiki Kano, Hideaki Kato, Takeru Abe, Ichiro Takeuchi

    PloS one   17 ( 10 )   e0273134   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The outcomes of coronavirus disease 2019 (COVID-19) treatment have improved due to vaccination and the establishment of better treatment regimens. However, the emergence of variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, and the corresponding changes in the characteristics of the disease present new challenges in patient management. This study aimed to analyze predictors of COVID-19 severity caused by the delta and omicron variants of SARS-CoV-2. METHODS: We retrospectively analyzed the data of patients who were admitted for COVID-19 at Yokohama City University Hospital from August 2021 to March 2022. RESULTS: A total of 141 patients were included in this study. Of these, 91 had moderate COVID-19, whereas 50 had severe COVID-19. There were significant differences in sex, vaccination status, dyspnea, sore throat symptoms, and body mass index (BMI) (p <0.0001, p <0.001, p <0.001, p = 0.02, p< 0.0001, respectively) between the moderate and severe COVID-19 groups. Regarding comorbidities, smoking habit and renal dysfunction were significantly different between the two groups (p = 0.007 and p = 0.01, respectively). Regarding laboratory data, only LDH level on the first day of hospitalization was significantly different between the two groups (p<0.001). Multiple logistic regression analysis revealed that time from the onset of COVID-19 to hospitalization, BMI, smoking habit, and LDH level were significantly different between the two groups (p<0.03, p = 0.039, p = 0.008, p<0.001, respectively). The cut-off value for the time from onset of COVID-19 to hospitalization was four days (sensitivity, 0.73; specificity, 0.70). CONCLUSIONS: Time from the onset of COVID-19 to hospitalization is the most important factor in the prevention of the aggravation of COVID-19 caused by the delta and omicron SARS-CoV-2 variants. Appropriate medical management within four days after the onset of COVID-19 is essential for preventing the progression of COVID-19, especially in patients with smoking habits.

    DOI: 10.1371/journal.pone.0273134

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  • COVID-19 mRNA vaccineによるアナフィラキシーの特徴

    菊池 優志, 大井 康史, 小川 史洋, 本澤 大志, 三澤 菜穂, 武田 知晃, 安部 猛, 竹内 一郎

    日本救急医学会雑誌   32 ( 12 )   1597 - 1597   2021年11月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • 二峰性の臨床経過の結果死亡したCOVID-19の症例

    三澤 菜穂, 松村 怜生, 大井 康史, 小川 史洋, 本澤 大志, 武田 知晃, 菊池 優志, 竹内 一郎

    日本救急医学会雑誌   32 ( 12 )   2609 - 2609   2021年11月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • P-SILIを誘発するリスク因子の検討

    大井 康史, 小川 史洋, 本澤 大志, 三澤 菜穂, 武田 知晃, 菊池 優志, 安部 猛, 竹内 一郎

    日本救急医学会雑誌   32 ( 12 )   2019 - 2019   2021年11月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • 救急外来において末梢静脈乳酸値は動脈乳酸値の代替え手段になり得るのか

    大井 康史, 森 浩介, 山縣 英尋, 野垣 文子, 武田 知晃, 渡邉 活, 坂口 裕介, 安部 猛, 伊巻 尚平, 竹内 一郎

    日本集中治療医学会雑誌   28 ( Suppl.2 )   336 - 336   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本集中治療医学会  

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  • AKI、見合せ、医療倫理 当院の死亡例からみるCOVID重症例におけるECMO/CHDFの適応について

    大井 康史, 小川 史洋, 本澤 大志, 三澤 菜穂, 武田 知晃, 菊池 優志, 安部 猛, 竹内 一郎

    日本急性血液浄化学会雑誌   12 ( Suppl. )   85 - 85   2021年9月

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    記述言語:日本語   出版者・発行元:(NPO)日本急性血液浄化学会  

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  • 重症COVID-19患者に対する遠隔人工呼吸器モニタリング

    松村 怜生, 大井 康史, 小川 史洋, 中嶋 賢人, 中川 智生, 竹内 一郎

    日本集中治療医学会雑誌   28 ( Suppl.2 )   393 - 393   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本集中治療医学会  

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  • Author Correction: The U‑shaped association of serum iron level with disease severity in adult hospitalized patients with COVID‑19. 国際誌

    Kentaro Tojo, Yoh Sugawara, Yasufumi Oi, Fumihiro Ogawa, Takuma Higurashi, Yukihiro Yoshimura, Nobuyuki Miyata, Hajime Hayami, Yoshikazu Yamaguchi, Yoko Ishikawa, Ichiro Takeuchi, Natsuo Tachikawa, Takahisa Goto

    Scientific reports   11 ( 1 )   16949 - 16949   2021年8月

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  • Temporal change in Syndecan-1 as a therapeutic target and a biomarker for the severity classification of COVID-19. 査読 国際誌

    Fumihiro Ogawa, Yasufumi Oi, Kento Nakajima, Reo Matsumura, Tomoki Nakagawa, Takao Miyagawa, Kazuya Sakai, Ryo Saji, Hayato Taniguchi, Kohei Takahashi, Takeru Abe, Masayuki Iwashita, Mototsugu Nishii, Ichiro Takeuchi

    Thrombosis journal   19 ( 1 )   55 - 55   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Coronavirus disease 2019 (COVID-19) pneumonitis associated with severe respiratory failure is associated with high mortality. The pathogenesis of COVID-19 is associated with microembolism or microvascular endothelial injuries. Here, we report that syndecan-1 (SDC-1), a component of the endothelial glycocalyx, may be a biomarker of severity classification for COVID-19 related to endothelial injury. METHODS AND ANALYSIS: We analyzed the data of COVID-19 patients for 1 year from February 2020 at Yokohama City University Hospital and Yokohama City University Medical Center Hospital. We selected COVID-19 patients who required admission care, including intensive care, and analyzed the classification of severe and critical COVID-19 retrospectively, using various clinical data and laboratory data with SDC-1 by ELISA. RESULTS: We analyzed clinical and laboratory data with SDC-1 in five severe COVID-19 and ten critical COVID-19 patients. In the two groups, their backgrounds were almost the same. In laboratory data, the LDH, CHE, and CRP levels showed significant differences in each group (P = 0.032, P < 0.0001, and P = 0.007, respectively) with no significant differences in coagulation-related factors (platelet, PT-INR, d-dimer, ISTH score; P = 0.200, 0.277, 0.655, and 0.36, respectively). For the clinical data, the SOFA score was significantly different from admission day to day 14 of admission (p < 0.0001). The SDC-1 levels of critical COVID-19 patients were significantly higher on admission day and all-time course compared with the levels of severe COVID-19 patients (P = 0.009 and P < 0.0001, respectively). CONCLUSIONS: Temporal change of SDC-1 levels closely reflect the severity of COVID-19, therefore, SDC-1 may be a therapeutic target and a biomarker for the severity classification of Covid-19.

    DOI: 10.1186/s12959-021-00308-4

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  • The U-shaped association of serum iron level with disease severity in adult hospitalized patients with COVID-19. 国際誌

    Kentaro Tojo, Yoh Sugawara, Yasufumi Oi, Fumihiro Ogawa, Takuma Higurashi, Yukihiro Yoshimura, Nobuyuki Miyata, Hajime Hayami, Yoshikazu Yamaguchi, Yoko Ishikawa, Ichiro Takeuchi, Natsuo Tachikawa, Takahisa Goto

    Scientific reports   11 ( 1 )   13431 - 13431   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that leads to severe respiratory failure (RF). It is known that host exposure to viral infection triggers an iron-lowering response to mitigate pathogenic load and tissue damage. However, the association between host iron-lowering response and COVID-19 severity is not clear. This two-center observational study of 136 adult hospitalized COVID-19 patients analyzed the association between disease severity and initial serum iron, total iron-binding capacity (TIBC), and transferrin saturation (TSAT) levels. Serum iron levels were significantly lower in patients with mild RF than in the non-RF group; however, there were no significant differences in iron levels between the non-RF and severe RF groups, depicting a U-shaped association between serum iron levels and disease severity. TIBC levels decreased significantly with increasing severity; consequently, TSAT was significantly higher in patients with severe RF than in other patients. Multivariate analysis including only patients with RF adjusted for age and sex demonstrated that higher serum iron and TSAT levels were independently associated with the development of severe RF, indicating that inadequate response to lower serum iron might be an exacerbating factor for COVID-19.

    DOI: 10.1038/s41598-021-92921-6

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  • Real-world evaluation of a computed tomography-first triage strategy for suspected Coronavirus disease 2019 in outpatients in Japan: An observational cohort study. 国際誌

    Shigeta Miyake, Takuma Higurashi, Takashi Jono, Taisuke Akimoto, Fumihiro Ogawa, Yasufumi Oi, Katsushi Tanaka, Yu Hara, Nobuaki Kobayashi, Hideaki Kato, Tsuneo Yamashiro, Daisuke Utsunomiya, Atsushi Nakajima, Tetsuya Yamamoto, Shin Maeda, Takeshi Kaneko, Ichiro Takeuchi

    Medicine   100 ( 22 )   e26161   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The Coronavirus disease 2019 pandemic continues to spread worldwide. Because of the absence of reliable rapid diagnostic systems, patients with symptoms of Coronavirus disease 2019 are treated as suspected of the disease. Use of computed tomography findings in Coronavirus disease 2019 are expected to be a reasonable method for triaging patients, and computed tomography-first triage strategies have been proposed. However, clinical evaluation of a computed tomography-first triage protocol is lacking.The aim of this study is to investigate the real-world efficacy and limitations of a computed tomography-first triage strategy in patients with suspected Coronavirus disease 2019.This was a single-center cohort study evaluating outpatients with fever who received medical examination at Yokohama City University Hospital, prospectively registered between 9 February and 5 May 2020. We treated according to the computed tomography-first triage protocol. The primary outcome was efficacy of the computed tomography-first triage protocol for patients with fever in an outpatient clinic. Efficacy of the computed tomography-first triage protocol for outpatients with fever was evaluated using sensitivity, specificity, positive predictive value, and negative predictive value. We conducted additional analyses of the isolation time of feverish outpatients and final diagnoses.In total, 108 consecutive outpatients with fever were examined at our hospital. Using the computed tomography-first triage protocol, 48 (44.9%) patients were classified as suspected Coronavirus disease 2019. Nine patients (18.8%) in this group were positive for severe acute respiratory syndrome coronavirus 2 using polymerase chain reaction; no patients in the group considered less likely to have Coronavirus disease 2019 tested positive for the virus. The protocol significantly shortened the duration of isolation for the not-suspected versus the suspected group (70.5 vs 1037.0 minutes, P < .001).Our computed tomography-first triage protocol was acceptable for screening patients with suspected Coronavirus disease 2019. This protocol will be helpful for appropriate triage, especially in areas where polymerase chain reaction is inadequate.

    DOI: 10.1097/MD.0000000000026161

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  • An evaluation of venous thromboembolism by whole-body enhanced CT scan for critical COVID-19 pneumonia with markedly rises of coagulopathy related factors: a case series study. 国際誌

    Fumihiro Ogawa, Yasufumi Oi, Kento Nakajima, Reo Matsumura, Tomoki Nakagawa, Takao Miyagawa, Takeru Abe, Ichiro Takeuchi

    Thrombosis journal   19 ( 1 )   26 - 26   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Coronavirus disease (COVID-19) pneumonitis associated with severe respiratory failure has a high mortality rate. Based on recent reports, the most severely ill patients present with coagulopathy, and disseminated intravascular coagulation (DIC)-like massive intravascular clot formation is frequently observed. Coagulopathy has emerged as a significant contributor to thrombotic complications. Although recommendations have been made for anticoagulant use for COVID-19, no guidelines have been specified. We describe four cases of critical COVID-19 with thrombosis detected by enhanced CT scan. The CT findings of all cases demonstrated typical findings of COVID-19 and pulmonary embolism or deep venous thrombus without critical exacerbation. Two patients died of respiratory failure due to COVID-19. DISCUSSION: Previous reports have suggested coagulopathy with thrombotic signs as the main pathological feature of COVID-19, but no previous reports have focused on coagulopathy evaluated by whole-body enhanced CT scan. Changes in hemostatic biomarkers, represented by an increase in D-dimer and fibrin/fibrinogen degradation products, indicated that the essence of coagulopathy was massive fibrin formation. Although there were no clinical symptoms related to their prognosis, critical COVID-19-induced systemic thrombus formation was observed. CONCLUSIONS: Therapeutic dose anticoagulants should be considered for critical COVID-19 because of induced coagulopathy, and aggressive follow-up by whole body enhanced CT scan for systemic venous thromboembolism (VTE) is necessary.

    DOI: 10.1186/s12959-021-00280-z

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  • 院外心停止への体外循環式心肺蘇生法の導入場所に対する検討

    坂口 裕介, 大井 康史, 森 浩介, 安部 猛, 伊巻 尚平, 竹内 一郎

    日本救急医学会関東地方会雑誌   42 ( 2 )   4 - 9   2021年3月

  • Combining IL-6 and SARS-CoV-2 RNAaemia-based risk stratification for fatal outcomes of COVID-19. 国際誌

    Ryo Saji, Mototsugu Nishii, Kazuya Sakai, Kei Miyakawa, Yutaro Yamaoka, Tatsuma Ban, Takeru Abe, Yutaro Ohyama, Kento Nakajima, Taro Hiromi, Reo Matsumura, Naoya Suzuki, Hayato Taniguchi, Tsuyoshi Otsuka, Yasufumi Oi, Fumihiro Ogawa, Munehito Uchiyama, Kohei Takahashi, Masayuki Iwashita, Yayoi Kimura, Satoshi Fujii, Ryosuke Furuya, Tomohiko Tamura, Akihide Ryo, Ichiro Takeuchi

    PloS one   16 ( 8 )   e0256022   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic rapidly increases the use of mechanical ventilation (MV). Such cases further require extracorporeal membrane oxygenation (ECMO) and have a high mortality. OBJECTIVE: We aimed to identify prognostic biomarkers pathophysiologically reflecting future deterioration of COVID-19. METHODS: Clinical, laboratory, and outcome data were collected from 102 patients with moderate to severe COVID-19. Interleukin (IL)-6 level and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copy number in plasma were assessed with ELISA kit and quantitative PCR. RESULTS: Twelve patients died or required ECMO owing to acute respiratory distress syndrome despite the use of MV. Among various variables, a ratio of oxygen saturation to fraction of inspired oxygen (SpO2/FiO2), IL-6, and SARS-CoV-2 RNA on admission before intubation were strongly predictive of fatal outcomes after the MV use. Moreover, among these variables, combining SpO2/FiO2, IL-6, and SARS-CoV-2 RNA showed the highest accuracy (area under the curve: 0.934). In patients with low SpO2/FiO2 (< 261), fatal event-rate after the MV use at the 30-day was significantly higher in patients with high IL-6 (> 49 pg/mL) and SARS-CoV-2 RNAaemia (> 1.5 copies/μL) compared to those with high IL-6 or RNAaemia or without high IL-6 and RNAaemia (88% vs. 22% or 8%, log-rank test P = 0.0097 or P < 0.0001, respectively). CONCLUSIONS: Combining SpO2/FiO2 with high IL-6 and SARS-CoV-2 RNAaemia which reflect hyperinflammation and viral overload allows accurately and before intubation identifying COVID-19 patients at high risk for ECMO use or in-hospital death despite the use of MV.

    DOI: 10.1371/journal.pone.0256022

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  • 当科で実践した重症COVID-19に対する治療戦略

    小川 史洋, 中川 智生, 松村 怜生, 中嶋 賢人, 大井 康史, 竹内 一郎

    日本救急医学会雑誌   31 ( 11 )   2036 - 2036   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • COVID-19肺炎と紛らわしいCT所見を呈した3症例

    中嶋 賢人, 小川 史洋, 大井 康史, 松村 怜生, 中川 智生, 安部 猛, 竹内 一郎

    日本救急医学会雑誌   31 ( 11 )   1300 - 1300   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • 当科で実践した重症COVID-19に対する治療戦略

    小川 史洋, 中川 智生, 松村 怜生, 中嶋 賢人, 大井 康史, 竹内 一郎

    日本救急医学会雑誌   31 ( 11 )   2036 - 2036   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • COVID-19肺炎と紛らわしいCT所見を呈した3症例

    中嶋 賢人, 小川 史洋, 大井 康史, 松村 怜生, 中川 智生, 安部 猛, 竹内 一郎

    日本救急医学会雑誌   31 ( 11 )   1300 - 1300   2020年11月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • Serum cholinesterase associated with COVID-19 pneumonia severity and mortality. 査読 国際誌

    Kento Nakajima, Takeru Abe, Ryo Saji, Fumihiro Ogawa, Hayato Taniguchi, Keishi Yamaguchi, Kazuya Sakai, Tomoki Nakagawa, Reo Matsumura, Yasufumi Oi, Mototsugu Nishii, Ichiro Takeuchi

    The Journal of infection   82 ( 2 )   282 - 327   2020年8月

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  • 健康食品の青汁を摂取し、高カリウム血症にて搬送された1例

    道下 貴弘, 大井 康史, 山縣 英尋, 高橋 充, 白澤 彩, 伊巻 尚平, 竹内 一郎

    日本救急医学会関東地方会雑誌   41 ( 2 )   329 - 332   2020年3月

  • 都市部における病院前心電図の検証

    山縣 英尋, 伊巻 尚平, 大井 康史, 野垣 文子, 森 浩介, 武田 知晃, 渡邊 活, 坂口 裕介, 竹内 一郎

    日本救急医学会関東地方会雑誌   41 ( 1 )   102 - 102   2020年1月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • 致死性不整脈による院外心停止に対する当院の治療戦略と検討

    坂口 裕介, 大井 康史, 野垣 文子, 森 浩介, 山縣 英尋, 武田 知晃, 渡邊 活, 伊巻 尚平

    日本救急医学会関東地方会雑誌   41 ( 1 )   111 - 111   2020年1月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • トリガーポイント注射にて全脊椎麻酔をきたした一例

    渡邉 活, 大井 康史, 野垣 文子, 森 浩介, 山縣 英尋, 武田 知晃, 坂口 裕介, 伊巻 尚平

    日本救急医学会関東地方会雑誌   41 ( 1 )   126 - 126   2020年1月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • 災害時におけるメディカルディレクター(MD)の設置とYMATによるMD代行

    大井 康史, 武田 知晃, 野垣 文子, 森 浩介, 山縣 英尋, 渡邉 活, 坂口 裕介, 伊巻 尚平, 竹内 一郎

    Japanese Journal of Disaster Medicine   24 ( 3 )   335 - 335   2019年12月

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    記述言語:日本語   出版者・発行元:(一社)日本災害医学会  

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  • 京浜急行衝突事故でのYMATによる救護所の変更

    武田 知晃, 大井 康史, 野垣 文子, 森 浩介, 山縣 英尋, 渡邉 活, 坂口 裕介, 伊巻 尚平, 竹内 一郎

    Japanese Journal of Disaster Medicine   24 ( 3 )   269 - 269   2019年12月

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    記述言語:日本語   出版者・発行元:(一社)日本災害医学会  

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  • Rapid Response Team(RRT)活動からみえてきた横浜市立市民病院のRapid Response System(RRS)の現状と問題点

    伊巻 尚平, 大井 康史, 野垣 文子, 森 浩介, 山縣 英尋, 武田 知晃, 渡邊 活, 坂口 裕介, 矢内 陽子, 住田 亮子

    医療の質・安全学会誌   14 ( Suppl. )   373 - 373   2019年11月

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    記述言語:日本語   出版者・発行元:(一社)医療の質・安全学会  

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  • 当院救急外来(ER)における緊急トリアージ現状と問題点

    伊巻 尚平, 大井 康史, 野垣 文子, 森 浩介, 山縣 英尋, 武田 知晃, 渡邊 活, 坂口 裕介

    医療の質・安全学会誌   14 ( Suppl. )   378 - 378   2019年11月

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    記述言語:日本語   出版者・発行元:(一社)医療の質・安全学会  

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  • Rapid Response Team活動からみえてきた現状と課題

    伊巻 尚平, 大井 康史, 野垣 文子, 森 浩介, 山縣 英尋, 武田 知晃, 渡辺 活, 坂口 裕介

    日本救急医学会雑誌   30 ( 9 )   742 - 742   2019年9月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • 診断に苦慮した気管支原性嚢胞による胸痛の一例

    山縣 英尋, 大井 康史, 白澤 彩, 高橋 充, 道下 貴弘, 伊巻 尚平, 竹内 一郎

    日本救急医学会雑誌   30 ( 9 )   838 - 838   2019年9月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • Quantitative capillary refill time predicts sepsis in patients with suspected infection in the emergency department: an observational study. 査読 国際誌

    Oi Yasufumi, Naoto Morimura, Aya Shirasawa, Hiroshi Honzawa, Yutaro Oyama, Shoko Niida, Takeru Abe, Shouhei Imaki, Ichiro Takeuchi

    Journal of intensive care   7   29 - 29   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Outcomes in emergent patients with suspected infection depend on how quickly clinicians evaluate the patients and start treatment. This study was performed to compare the predictive ability of the quantitative capillary refill time (Q-CRT) as a new rapid index versus the quick sequential organ failure assessment (qSOFA) score and the systemic inflammatory response syndrome (SIRS) score for sepsis screening in the emergency department. Methods: This was a multicenter, observational, retrospective study of adult patients with suspected infection. The area under the curve (AUC) of receiver operating characteristic curve analyses and multivariate analyses were used to explore associations of the Q-CRT with the qSOFA score, SIRS score, and lactate concentration. Results: Of the 75 enrolled patients, 48 had sepsis. The AUC, sensitivity, and specificity of Q-CRT were 0.74, 58%, and 81%, respectively; those for the qSOFA score were 0.83, 66%, and 100%, respectively; those for the SIRS score were 0.61, 81%, and 40%, respectively, for SIRS score; and those for the lactate concentration were 0.76, 72%, and 81%, respectively. We found no statistically significant differences in the AUC between the scores. We then combined the Q-CRT and qSOFA score (Q-CRT/qSOFA combination) for sepsis screening. The AUC, sensitivity, and specificity of Q-CRT/qSOFA combination were 0.82, 83%, and 81%, respectively. Conclusions: In this study, Q-CRT/qSOFA combination had better sensitivity than the qSOFA score alone and better specificity than the SIRS score alone. There was no significant difference in accuracy between Q-CRT/qSOFA combination and the qSOFA score or lactate concentration. The ability of the Q-CRT to predict sepsis may be similar to that of the qSOFA score or serum lactate concentration; therefore, measurement of the Q-CRT may be an alternative for invasive measurement of the blood lactate concentration in evaluating patients with suspected sepsis.

    DOI: 10.1186/s40560-019-0382-4

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  • Association between venous blood lactate levels and differences in quantitative capillary refill time. 査読 国際誌

    Yasufumi Oi, Kosuke Sato, Ayako Nogaki, Mafumi Shinohara, Jun Matsumoto, Takeru Abe, Naoto Morimura

    Acute medicine & surgery   5 ( 4 )   321 - 328   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aim: Capillary refill time has been widely adopted for clinical assessment of the circulatory status of patients in emergency settings. We previously introduced quantitative capillary refill time and found a positive association between longer quantitative capillary refill time and higher lactate levels in the intensive care units, but not in the emergency department. In this study, we aimed to identify a quantitative and clinically applicable index of circulatory status (ΔAb) that can be measured with quantitative capillary refill time, then evaluated the linear association between this index and lactate levels in the emergency department. Methods: We undertook a prospective single-center observational study at a university hospital from November 2015 to July 2016. We included 139 patients with endogenous diseases to test the association between quantitative capillary refill time, ΔAb (measured with a pulse oximeter), and lactate levels. Results: ΔAb was independently and significantly associated with high lactate levels (odds ratio [95% confidence interval]: 0.16 [0.05-0.45]). Conclusions: We introduced ΔAb, measured using quantitative capillary refill time, as a surrogate index of lactate levels to overcome the shortcomings of capillary refill time. We showed that ΔAb is a feasible, non-invasive, and rapid assessment of patients with high lactate levels in emergency primary care settings. Future multicenter studies with a longitudinal design should be undertaken to verify our findings.

    DOI: 10.1002/ams2.348

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  • 当院ERに搬送された鼻出血患者の現況

    佐藤 公亮, 安部 猛, 野垣 文子, 大井 康史, 松本 順, 竹内 一郎

    日本救急医学会関東地方会雑誌   39 ( 1 )   140 - 140   2018年1月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • 横浜市立大学附属二病院でのハイブリッド型救急研修の目標設定からのPDCAサイクル

    松本 順, 篠原 真史, 大井 康史, 佐藤 公亮, 野垣 文子, 安部 猛, 内山 宗人, 森村 尚登

    日本救急医学会関東地方会雑誌   38 ( 1 )   90 - 90   2017年2月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • 交通事故により腸間膜損傷をきたし、遅発性に小腸壊死となった1例 査読

    酒井 拓磨, 古谷 良輔, 宮崎 弘志, 望月 聡之, 西村 祥一, 大井 康史, 幸野 真樹, 佐藤 公亮, 新井 悠介

    日本救急医学会関東地方会雑誌   35 ( 2 )   277 - 280   2014年12月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • 高位頸髄損傷患者の呼吸不全に対するHFT(High Flow Theraphy)の導入経験 査読

    西村 祥一, 古谷 良輔, 宮崎 弘志, 望月 聡之, 大井 康史, 酒井 拓磨, 幸野 真樹, 佐藤 公亮, 新井 悠介

    日本救急医学会関東地方会雑誌   35 ( 2 )   376 - 378   2014年12月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • 重症部門の業務内容とインシデントレポート調査に基づく重症患者情報管理システムの導入と改良 査読

    古谷 良輔, 宮崎 弘志, 大井 康史, 望月 聡之, 西村 祥一, 酒井 拓磨, 佐藤 公亮, 岩下 眞之, 藤井 由美恵, 武井 佐和子

    日本救急医学会関東地方会雑誌   35 ( 2 )   197 - 203   2014年12月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • 気管挿管時にエアウェイスコープが有効でなかった薬剤性アナフィラキシーの1症例 査読

    大井 康史, 古郡 慎太郎, 酒井 拓磨, 松本 順, 矢澤 利枝, 古谷 良輔, 伊巻 尚平

    日本救急医学会雑誌   25 ( 5 )   229 - 232   2014年5月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • 好酸球増多症による心筋炎・筋膜炎症状を来した1症例 査読

    本澤 大志, 大井 康史, 山田 淳貴, 早川 翔, 古郡 慎太郎, 西村 祥一, 望月 聡之, 宮崎 弘志, 今泉 純, 古谷 良輔

    日本救急医学会関東地方会雑誌   34 ( 2 )   301 - 302   2013年12月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • Pediatric mumps with laryngeal edema. 査読 国際誌

    Yujiro Hattori, Yasufumi Oi, Ryo Matsuoka, Yumi Daimon, Asami Ito, Wataru Kubota, Kyoko Konishi, Toshimi Onguchi, Akihiro Sato, Yukio Yamashita, Jun Ishihara

    Pediatric emergency care   29 ( 10 )   1104 - 6   2013年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Mumps virus infection primarily affects the salivary glands and may incur various complications. Laryngeal edema is such a rare complication that few adult cases have been reported. We report the first known pediatric patient with mumps with laryngeal edema. An 8-year-old boy developed dyspnea after a rapidly progressive swelling of his face and neck. Laryngoscopy revealed edematous changes in the supraglottic and subglottic regions, and computed tomography confirmed significant laryngeal edema in addition to swelling of the cervical soft tissue and the salivary glands. Laboratory findings revealed a high serum amylase level and confirmed the diagnosis of mumps. Intravenous steroid administration alleviated the dyspnea, although the patient required temporary tracheal intubation to maintain airway patency. He did not need tracheotomy and did not experience any other complications. Laryngeal edema must be regarded as a rare, potentially life-threatening complication of mumps. When mumps is diagnosed with significant swelling of the neck, an emergency airway should be established to prevent airway obstruction.

    DOI: 10.1097/PEC.0b013e3182a60049

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  • エアウェイスコープを用いた気管挿管が不可能であった1症例

    大井 康史, 古郡 慎太郎, 酒井 拓磨, 松本 順, 矢澤 利枝, 伊巻 尚平, 古谷 良輔, 西村 祥一, 宮崎 弘志, 今泉 純, 望月 聡之

    日本救急医学会雑誌   23 ( 10 )   643 - 643   2012年10月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • 下膵臓動脈瘤破裂による急性腹症の1例 査読

    阿部 弘基, 大井 康史, 鈴木 弘之, 山田 俊介, 安久 正哲, 土井 智喜, 馬場 紀行, 濱田 幸一, 小菅 宇之, 森脇 義弘, 田原 良雄, 鈴木 範行, 森村 尚登, 竹林 茂生

    日本救急医学会関東地方会雑誌   32   124 - 125   2011年12月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • 心肺停止蘇生後患者に対する脳低温療法中の鎮静の指標にbispectral index(BIS)を用いた2症例 査読

    高木 俊介, 岩下 眞之, 大川 卓巳, 大井 康史, 松崎 昇一, 下山 哲, 田原 良雄, 鈴木 範行

    日本集中治療医学会雑誌   18 ( 3 )   387 - 392   2011年7月

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    記述言語:日本語   出版者・発行元:(一社)日本集中治療医学会  

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  • 【もう怖くない!人工呼吸器マスターガイド】(1章)器械は怖くない! パルスオキシメーター 査読

    大井 康史

    呼吸器ケア   ( 2011夏季増刊 )   50 - 56   2011年6月

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    記述言語:日本語   出版者・発行元:(株)メディカ出版  

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  • 【Abdominal Compartment Syndrome】Abdominal Compartment Syndromeに対するOpen Abdomen ManagementとVacuum Assisted Closure 査読

    森脇 義弘, 岩下 眞之, 大井 康史, 藤 雅文, 土井 智喜, 田原 良雄, 荒田 愼寿, 鈴木 範行

    ICUとCCU   34 ( 7 )   537 - 546   2010年7月

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    記述言語:日本語   出版者・発行元:医学図書出版(株)  

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  • アニリン中毒による重症メトヘモグロビン血症の1例 査読

    森 浩介, 岩下 眞之, 大川 卓巳, 大井 康史, 高木 俊介, 松崎 昇一, 下山 哲, 田原 良雄, 鈴木 範行

    日本救急医学会関東地方会雑誌   30   158 - 159   2009年12月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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  • 下部消化管穿孔による敗血症性ショックにPMX-DHPが奏効した慢性腎不全の1症例 査読

    大井 康史, 荒田 慎寿, 岩下 眞之, 加藤 真, 小菅 宇之, 森脇 義弘, 下山 哲, 杉山 貢, 鈴木 範行

    エンドトキシン血症救命治療研究会誌   13 ( 1 )   177 - 182   2009年10月

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    記述言語:日本語   出版者・発行元:(株)自然科学社  

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  • 口腔内杙創の2症例 査読

    大井 康史, 本村 健一郎, 後藤 正美, 熊本 宜文, 今泉 純, 鈴木 淳一

    日本外傷学会雑誌   23 ( 1 )   15 - 19   2009年1月

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    記述言語:日本語   出版者・発行元:(一社)日本外傷学会  

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  • 胸痛を主訴に来院した脊髄梗塞の1例 査読

    大井 康史, 外山 英志, 田原 良雄, 豊田 洋, 小菅 宇之, 鈴木 範行, 杉山 貢

    日本救急医学会関東地方会雑誌   26   94 - 95   2005年12月

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    記述言語:日本語   出版者・発行元:日本救急医学会-関東地方会  

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MISC

  • 横浜・横須賀救急科総合研修プログラムにおける私たちの工夫

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    日本救急医学会雑誌   35 ( 11 )   783 - 783   2024年11月

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  • Ca拮抗薬中毒による心肺停止に対して、薬物療法で救命し得た一例

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    日本救急医学会雑誌   35 ( 11 )   659 - 659   2024年11月

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  • 心肺蘇生法の医学生・一般市民への教育に対するVRの有用性の検討

    小川 史洋, 大井 康史, 佐藤 公亮, 本澤 大志, 佐治 龍, 山崎 敦子, 稲森 正彦, 竹内 一郎

    日本救急医学会雑誌   35 ( 11 )   664 - 664   2024年11月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • COVID-19急性期に肺ムコール症を発症し救命し得た1例

    四宮 祥恵, 大井 康史, 小川 史洋, 本澤 大志, 三澤 菜穂, 水上 紗緒里, 丸岩 伯章, 貞広 智瑛梨, 竹内 一郎

    日本集中治療医学会雑誌   31 ( Suppl.1 )   S541 - S541   2024年9月

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  • 働き方改革にむけた救急診療と集中治療の並行診療における遠隔病態把握システムの有用性の検討

    小川 史洋, 大井 康史, 本澤 大志, 三澤 菜穂, 四宮 祥恵, 水上 紗緒里, 丸岩 伯章, 貞広 智瑛梨, 高木 俊介, 竹田 美希, 竹内 一郎

    日本救急医学会雑誌   34 ( 12 )   715 - 715   2023年12月

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  • 横浜で取り組む多数傷病者案件の現場医療統括 京浜急行脱線・炎上事故の実例から考える

    大井 康史, 竹内 一郎

    日本病院前救急診療医学会誌   18 ( 1 )   25 - 25   2023年11月

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    記述言語:日本語   出版者・発行元:日本病院前救急診療医学会  

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  • 感染症患者の末梢静脈乳酸値は動脈乳酸値の代替え手段になり得るのか

    大井 康史, 伊巻 尚平, 竹内 一郎

    臨床モニター   33 ( Suppl. )   109 - 109   2022年6月

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  • 血液ガス分析における乳酸値の動脈血と静脈血の関係の検討

    大井 康史, 山縣 英尋, 森 浩介, 野垣 文子, 武田 知晃, 渡辺 活, 坂口 裕介, 安部 猛, 伊巻 尚平, 竹内 一郎

    日本救急医学会雑誌   30 ( 9 )   687 - 687   2019年9月

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  • qSOFA1点以下の群からQ-CRTを用いて敗血症を予測する検討

    大井 康史, 大山 裕太郎, 新居田 翔子, 本澤 大志, 白澤 彩, 安部 猛, 伊巻 尚平, 森村 尚登, 竹内 一郎

    日本救急医学会雑誌   29 ( 10 )   485 - 485   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本救急医学会  

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  • 定量化毛細血管再充満時間(Q-CRT)と敗血症に関する研究

    大井 康史, 佐藤 公亮, 野垣 文子, 篠原 真史, 松本 順, 安部 猛, 伊巻 尚平, 竹内 一郎, 森村 尚登

    日本集中治療医学会雑誌   25 ( Suppl. )   [O72 - 1]   2018年2月

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  • 定量化した毛細血管充満時間(Q-CRT)の差とショックの予測に関する研究

    大井 康史, 佐藤 公亮, 野垣 文子, 篠原 真史, 松本 順, 安部 猛, 森村 尚登

    日本救急医学会雑誌   27 ( 9 )   419 - 419   2016年9月

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  • 当救命救急センターにおける横浜市重症外傷センター運用開始後の現状

    中村京太, 土井智喜, 六車崇, 問田千晶, 大塚剛, 大井康史, 谷口隼人, 松崎昇一, 春成伸之, 森村尚登

    日本臨床救急医学会雑誌   18 ( 2 )   342   2015年4月

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    記述言語:日本語  

    J-GLOBAL

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  • 救急ICUにおけるせん妄の発症リスクの検証

    大井 康史, 六車 崇, 問田 千晶, 谷口 隼人, 大塚 剛, 土井 智喜, 松崎 昇一, 中村 京太, 日野 耕介, 森村 尚登

    日本集中治療医学会雑誌   22 ( Suppl. )   [DO26 - 5]   2015年1月

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    記述言語:日本語   出版者・発行元:(一社)日本集中治療医学会  

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  • 定量化毛細血管再充満時間(Q‐CRT)と組織潅流に係る研究:自動指尖圧迫装置による至適圧の検討

    森村尚登, 大井康史, 大塚剛, 松森響子, 六車崇, 谷口隼人, 問田千晶, 土井智喜, 松崎昇一, 中村京太

    日本集中治療医学会学術集会(Web)   42nd   DP101-5 (WEB ONLY)   2015年

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    記述言語:日本語  

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