Updated on 2025/07/09

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写真a

 
Kazuho Maeda
 
Organization
School of Medicine Medical Course Forensic Medicine Assistant Professor
Title
Assistant Professor
Profile
心臓性突然死の遺伝子変異解析、入浴死を含む溺死診断に有用なバイオマーカー探索
External link

Degree

  • 博士（医学） ( 北里大学 )

Research Interests

  • DNA多型

  • 個人識別

  • 法医学

  • 血液型

Research Areas

  • Life Science / Forensics medicine

Education

  • Kitasato University

    2009.4 - 2013.3

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  • Kitasato University

    2007.4 - 2009.3

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  • Kitasato University

    2003.4 - 2007.3

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Research History

  • Yokohama City University   Assistant Professor

    2019.4

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  • Kagoshima University   Assistant Professor

    2016.4 - 2019.3

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  • 北里大学医学部   法医学   特任助教

    2013.4 - 2016.3

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Professional Memberships

Papers

  • Layer-specific proteomic profiling of human normal heart. International journal

    Yu Kakimoto, Atsushi Ueda, Yayoi Kimura, Tomoko Akiyama, Masayuki Tanaka, Haruka Ikeda, Shotaro Isozaki, Kazuho Maeda, Motoki Osawa

    Pathology, research and practice   260   155453 - 155453   2024.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: The organized functioning of the anisotropic myocardial layers-including the inner longitudinal, middle circular, and outer longitudinal layers-is essential for stable systemic circulation. However, the proteomic profile of each myocardial layer has not been studied yet. Here, we aimed to elucidate the layer-specific proteomic profile of human cardiac tissue using microscopic sampling. METHODS: Normal hearts were obtained from five autopsy cases, and cardiomyocytes were microdissected separately from the three myocardial layers of the left ventricle. Histological analysis and shotgun proteomic profiling were performed, followed by immunohistochemical analysis. RESULTS: Histologically, no significant changes were observed among the three layers regarding cardiomyocyte diameter and myocardial fibrosis. Totally 1220 proteins-comprising 9404 peptides-were identified from 15 samples, of which the expression levels of 92 proteins were significantly altered among the layers. Gene ontology enrichment analysis revealed that the proteins specifically elevated in the inner and outer layers mostly belonged to the actin filament-binding protein group. In particular, MYH1 was highly expressed in cardiomyocytes in the outer layer, and CTNNA3 was highly expressed at the intercalated disc in the inner layer. CONCLUSIONS: This is the first report on layer-specific proteomic profiling of human normal hearts. Anisotropic profiles of actin filament-binding proteins in myocardial layers may contribute to the anisotropic contractile and conductive abilities of the heart. Knowledge of the layer-specific proteome profiles of a human heart in the normal state can aid in further research on cardiac pathology, such as the prognosis and treatment of focal myocardial infarction.

    DOI： 10.1016/j.prp.2024.155453

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  • Distinguishing true from pseudo hematoma in the cervical spinal canal using postmortem computed tomography. Reviewed International journal

    Hikaru Kuninaka, Yosuke Usumoto, Momoka Tanabe, Noriko Ogawa, Moe Mukai, Ayako Nasu, Kazuho Maeda, Chiaki Fuke, Shungo Sawamura, Tsuneo Yamashiro, Daisuke Utsunomiya, Yoko Ihama

    Legal medicine (Tokyo, Japan)   66   102358 - 102358   2023.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    Spinal cord injury is difficult to detect directly on postmortem computed tomography (PMCT) and it is usually diagnosed by indirect findings such as a hematoma in the spinal canal. However, we have encountered cases where the hematoma-like high-attenuation area in the cervical spinal canal was visible on PMCT, while no hematoma was observed at autopsy; we called it a "pseudo hematoma in the cervical spinal canal (pseudo-HCSC)." In this retrospective study, we performed statistical analysis to distinguish true from pseudo-HCSC. The cervical spinal canal was dissected in 35 autopsy cases with a hematoma-like high-attenuation area (CT values 60-100 Hounsfield Unit (HU)) in the spinal canal from the first to the fourth cervical vertebrae in axial slices of PMCT images. Of these 22 had a hematoma and 13 did not (pseudo-HCSC). The location and length of the hematoma-like high-attenuation and spinal cord areas were assessed on reconstructed PMCT images, true HCSC cases had longer the posterior hematoma-like area and shorter the spinal cord area in the midline of the spinal canal (P < 0.05). Furthermore, we found that true HCSC cases were more likely to have fractures and gases on PMCT while pseudo-HCSC cases were more likely to have significant facial congestion (P < 0.05). We suggest that pseudo-HCSC on PMCT is related to congestion of the internal vertebral venous plexus. This study raises awareness about the importance of distinguishing true HCSC from pseudo-HCSC in PMCT diagnosis, and it also presents methods for differentiation between these two groups.

    DOI： 10.1016/j.legalmed.2023.102358

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  • Quantitative analysis of respiratory viral distribution in forensic autopsy cases. Reviewed International journal

    Momoka Tanabe, Kazuho Maeda, Yosuke Usumoto, Hikaru Kuninaka, Moe Mukai, Ayako Nasu, Chiaki Fuke, Yoko Ihama

    Forensic science international   339   111419 - 111419   2022.10

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Respiratory viruses can cause fatal systemic infections; therefore, post-mortem diagnosis is essential in forensic autopsy cases. However, little is known regarding the distribution of respiratory viruses in the body. In this study, we investigated the anatomical distribution of respiratory viruses in 48 forensic autopsy cases suspected of viral infections at our institute. Fast Track Diagnostics (FTD) Respiratory Pathogens 21 was used as a screening test for 20 respiratory viruses in nasopharyngeal swabs. In cases with positive results for virus detection by the screening test, the detected viruses were quantified in body fluid and organ specimens by virus-specific real-time reverse transcription polymerase chain reaction (RT-PCR) and digital PCR. Viruses were detected in 33 cases, with the viral distribution and load differing among the cases. Since various respiratory viruses were detected from the nasopharyngeal swab and its viral load was higher than those of other body fluid specimens, the nasopharyngeal swab was suggested as a useful specimen for the post-mortem detection of respiratory viruses. Viruses were detected in almost all specimens including the serum in six cases. Considering the viral distribution in the body, pathological findings, and ante-mortem symptoms, these cases were presumed to be systemically infected, having died in the acute infection phase. In conclusion, the anatomical distribution of respiratory viruses can help indicate ante-mortem systemic conditions and the cause of death.

    DOI： 10.1016/j.forsciint.2022.111419

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  • An autopsy case of COVID-19-like acute respiratory distress syndrome after mRNA-1273 SARS-CoV-2 vaccination. Reviewed International journal

    Yukihiro Yoshimura, Hiroaki Sasaki, Nobuyuki Miyata, Kazuhito Miyazaki, Koji Okudela, Yoko Tateishi, Hiroyuki Hayashi, Ai Kawana-Tachikawa, Hiromichi Iwashita, Kazuho Maeda, Yoko Ihama, Yasuyoshi Hatayama, Akihide Ryo, Natsuo Tachikawa

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   121   98 - 101   2022.8

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    We report the first case with COVID-19-like acute respiratory distress syndrome after mRNA-1273 SARS-CoV-2 vaccination. An 88-year-old woman developed dyspnea several hours after vaccination with the second dose of mRNA-1273. She was hospitalized on day nine due to worsening dyspnea. Chest computed tomography showed bilateral ground-glass opacities and consolidations, mainly in the peripheral lung areas. Repeat polymerase chain reaction tests for SARS-CoV-2 were negative, although the serum level of antibodies against spike protein was extremely elevated. Her condition did not improve with high-dose corticosteroids and high-flow nasal cannula oxygen therapy; she died on day 18. Autopsy findings revealed very early-phase diffuse alveolar damage in the whole lung without other lung diseases. The clinical and pathological findings suggested vaccine-induced acute respiratory distress syndrome. Serological and pathological tests might be useful to differentiate the disease from COVID-19.

    DOI： 10.1016/j.ijid.2022.04.057

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  • ベビーチェアのシートベルトの不適切な装着により死亡した幼児の1例 Reviewed

    田邊 桃佳, 臼元 洋介, 國中 光, 解良 仁美, 佐藤 若菜, 向井 萌, 那須 亜矢子, 前田 一輔, 福家 千昭, 井濱 容子

    法医学の実際と研究   ( 64 )   107 - 111   2021.11

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    Language：Japanese   Publisher：法医学談話会  

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  • リアルタイムRT-PCR法により体液や臓器から新型コロナウイルスを検出した一例 Reviewed

    田邊 桃佳, 前田 一輔, 解良 仁美, 國中 光, 佐藤 若菜, 向井 萌, 那須 亜矢子, 臼元 洋介, 福家 千昭, 井濱 容子

    法医病理   27 ( 1 )   75 - 77   2021.7

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    Authorship：Corresponding author   Language：Japanese   Publisher：日本法医病理学会  

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  • Kinetics and distribution of benzalkonium compounds with different alkyl chain length following intravenous administration in rats. Reviewed International journal

    Hitomi Kera, Chiaki Fuke, Yosuke Usumoto, Ayako Nasu, Kazuho Maeda, Moe Mukai, Wakana Sato, Momoka Tanabe, Hikaru Kuninaka, Yoko Ihama

    Legal medicine (Tokyo, Japan)   48   101821 - 101821   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    Benzalkonium chloride is widely used in disinfectants. Several toxicological and fatal cases have been reported; however, little is known about its kinetics and distribution. We investigated the kinetic characteristics and distribution of benzalkonium cation (BZK) based on the length of the alkyl chains C12, C14, and C16. Rats were treated intravenously with BZK solution (dose, 13.9 mg/kg) containing equal amounts of the three homologues. Kinetic parameters in the blood were assessed, and BZK distribution in the blood and tissues was examined both in rapid intravenous (IV) and drip intravenous (DIV) administrations. BZK concentrations were analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). BZK with longer alkyl chains showed lower elimination tendencies and remained in the blood for a longer duration. Concentrations of BZK were higher in the heart, lung, spleen, and kidney than those in the blood, and lower in the brain and fat. In both the IV and DIV groups, the lung, liver, spleen, and fat samples showed higher concentrations of the longer alkyl chains (BZK-C12 < -C14 < -C16), and the opposite trend was observed in the kidney (BZK-C16 < -C14 < -C12). Only the heart and muscle samples displayed the homologues in ratios comparable to the original administered solutions. Differences between IV and DIV groups could be identified by comparing concentrations of BZK homologues in the heart, lung, spleen, and kidney samples. We found that the kinetics and distribution of BZK were influenced by the alkyl chain length, and analysing each BZK homologues in blood and tissue samples may provide useful information.

    DOI： 10.1016/j.legalmed.2020.101821

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  • 蔓(かずら)による頸部圧迫で窒息死した1剖検例 Reviewed

    前田 一輔, 林 敬人, 中前 琢磨, 肥後 恵理, 小片 守

    法医病理   23 ( 2 )   83 - 88   2017.12

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  • 搬送時のCT検査で内因性肝臓破裂による病死を疑われた外傷性肝損傷の剖検例 Reviewed

    前田 一輔, 入江 渉, 村上 千香子, 佐々木 千寿子, 大石 桃子, 中丸 尚美, 中村 茂基, 栗原 克由

    法医学の実際と研究   ( 58 )   133 - 137   2015.11

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    Authorship：Lead author   Language：Japanese   Publisher：法医学談話会  

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  • A case of death caused by abuse of a synthetic cannabinoid N-1-naphthalenyl-1-pentyl-1H-indole-3-carboxamide Reviewed

    Chizuko Sasaki, Takeshi Saito, Tatsuo Shinozuka, Wataru Irie, Chikako Murakami, Kazuho Maeda, Naomi Nakamaru, Momoko Oishi, Shigeki Nakamura, Katsuyoshi Kurihara

    FORENSIC TOXICOLOGY   33 ( 1 )   165 - 169   2015.1

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    DOI： 10.1007/s11419-014-0246-5

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  • Analysis of gene mutations encoding sarcomeric proteins in sudden death cases caused by cardiomyopathy Reviewed

    Murakami C, Nakamura S, Maeda K, Irie W, Oishi M, Sasaki C, Nakamaru N, Kurihara K

    The Kitasato Medical Journal   44   47 - 55   2014

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  • Simultaneous determination of 5 psychotropic drugs of various types in an autopsy case of acute multiple drug poisoning. Reviewed International journal

    Chizuko Sasaki, Tatsuo Shinozuka, Chikako Murakami, Wataru Irie, Kazuho Maeda, Toshimasa Watanabe, Naomi Nakamaru, Masataka Furukawa, Shigeki Nakamura, Katsuyoshi Kurihara

    Forensic science international   227 ( 1-3 )   90 - 4   2013.4

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    We attempted the simultaneous determination of 5 drugs, mirtazapine, sertraline, chlorpromazine, amoxapine and zolpidem, detected in a gas chromatography-mass spectrometry screening test in an autopsy case. The solid-phase extraction of the analytes from biological samples was achieved using Oasis(®)HLB cartridges (Waters, Milford, MA, USA). Gas chromatography was performed on a HP-5MS fused silica capillary column (30 m × 0.25 mm i.d., 0.25 μm film thickness, Agilent Technologies). The mass spectrometer was operated with an electron energy of 70 eV in electron impact mode. The qualitative and quantitative analyses were performed in full-scan mode and the selected ion monitoring mode, respectively. The total ion chromatogram showed good separation of these drugs. Linear graphs were obtained with good correlation coefficients for these drugs from 0.001 to 2.0 μg/mL (r(2)=0.9909-0.9986) using imipramine-d6 as an internal standard. The recoveries of these drugs were found to be 62.8-88.0% in spiked whole blood. Mirtazapine, sertraline, chlorpromazine, amoxapine and zolpidem were found in post-mortem samples of the deceased at concentrations of 2.67, 0.07, 0.25, 0.32 and 0.68 μg/mL, respectively. The concentration of mirtazapine was within the lethal level and those of amoxapine and zolpidem were within the toxic level. We diagnosed that the cause of death was acute multiple drug poisoning. The simple and practical procedure used in this study is useful for the simultaneous determination of psychotropic drugs of various types in post-mortem biological samples.

    DOI： 10.1016/j.forsciint.2012.11.015

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  • ABO genotyping by TaqMan assay and allele frequencies in a Japanese population Reviewed

    Kazuho Maeda, Shigeki Nakamura, Chikako Murakami, Wataru Irie, Toshimasa Watanabe, Chizuko Sasaki, Naomi Nakamaru, Masataka Furukawa, Katsuyoshi Kurihara

    LEGAL MEDICINE   15 ( 2 )   57 - 60   2013.3

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    DOI： 10.1016/j.legalmed.2012.08.009

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  • Mutational analysis of the mitochondrial DNA detected in sudden cardiac death caused by cardiomyopathy Reviewed

    Kobayashi M, Nakamura S, Murakami C, Maeda K, Irie W, Hayashi M, Sasaki C, Nakamaru N, Furukawa M, Kurihara K

    The Kitasato Medical Journal   41   127 - 135   2011

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  • Analysis of the sarcomere protein gene mutation on cardiomyopathy - Mutations in the cardiac troponin I gene Reviewed

    Chikako Murakami, Shigeki Nakamura, Masamune Kobayashi, Kazuho Maeda, Wataru Irie, Bunta Wada, Maiko Hayashi, Chizuko Sasaki, Naomi Nakamaru, Masataka Furukawa, Katsuyoshi Kurihara

    LEGAL MEDICINE   12 ( 6 )   280 - 283   2010.11

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    DOI： 10.1016/j.legalmed.2010.07.002

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  • Diagnostic significance of myocardial stress markers in unnatural death Reviewed

    Irie W, Furukawa M, Murakami C, Kobayashi M, Maeda K, Nakamura S, Kurihara K

    The Kitasato Medical Journal   40   35 - 41   2010

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  • A case of V-A shunt catheters migration into the pulmonary artery. Reviewed International journal

    Wataru Irie, Masataka Furukawa, Chikako Murakami, Masamune Kobayashi, Kazuho Maeda, Naomi Nakamaru, Chizuko Sasaki, Kota Shibuya, Shigeki Nakamura, Katsuyoshi Kurihara

    Legal medicine (Tokyo, Japan)   11 ( 1 )   25 - 9   2009.1

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    A man in his sixties, who developed CPA at home, was transferred to the emergency center. Since CT images revealed a tube-shaped foreign body in the pulmonary artery, pulmonary embolism was initially suspected; however, this did not lead to a definite diagnosis. Autopsy revealed that the foreign body in the cadaver was a fragment of a V-A shunt catheter implanted about 30 years previously for the treatment of hydrocephalus. Although fibrous adhesion of a part of the catheter to the pulmonary artery wall was seen, suggesting that a fracture of the catheter had occurred a long time before, it was not known when the fracture had occurred. Since no pulmonary arterial obstruction secondary to the catheter or new thrombi, which had been initially suspected, were observed, the cause of death was determined to be ischemic cardiac failure. A fracture of a shunt catheter may be typically associated with some clinical manifestations, which are often found and treated. In this case, however, no symptoms appeared and the fracture of the shunt catheter remained untreated for a long time. This case was therefore considered to be extremely rare, and is an example of how a serious iatrogenic disease could occur.

    DOI： 10.1016/j.legalmed.2008.06.005

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  • 特異な形態を呈した腎動脈瘤破裂の一例 Reviewed

    入江 渉, 古川 理孝, 村上 千香子, 中丸 尚美, 佐々木 千寿子, 小林 正宗, 前田 一輔, 中村 茂基, 朴 宜雨, 栗原 克由

    法医学の実際と研究   ( 51 )   273 - 273   2008.12

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MISC

  • 減圧症の死後診断マーカーの探索 スキューバダイビング関連死の診断方法の検討

    筌場 さき, 前田 一輔, 井濱 容子, 二宮 賢司

    琉球医学会誌   41 ( 1-4 )   63 - 63   2022

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  • 原因不明の感染性心内膜炎による突然死例

    林 敬人, 前田 一輔, 中前 琢磨, 肥後 恵理, 小片 守

    法医病理   24 ( 1 )   10 - 11   2018.6

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  • The case of 2 siblings that identified not only by DNA profiling

    Kazuho Maeda, Chikako Murakami, Wataru Irie, Chizuko Sasaki, Momoko Oishi, Naomi Nakamaru, Shigeki Nakamura, Katsuyoshi Kurihara

    Forensic Science International: Genetics Supplement Series   5   e555 - e556   2015.12

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  • 心臓性突然死の遺伝子解析 SCN5A遺伝子の変異解析

    村上 千香子, 前田 一輔, 入江 渉, 大石 桃子, 佐々木 千寿子, 中丸 尚美, 中村 茂基, 栗原 克由

    DNA多型   23 ( 1 )   177 - 180   2015.7

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    Language：Japanese   Publisher：(一社)日本DNA多型学会  

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  • 心臓性突然死の遺伝子解析 KCNQ1遺伝子の変異解析

    村上 千香子, 前田 一輔, 入江 渉, 大石 桃子, 佐々木 千寿子, 中丸 尚美, 中村 茂基, 栗原 克由

    DNA多型   22 ( 1 )   211 - 213   2014.7

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  • ANKRD1のg.7260_7291領域における個人識別への応用

    前田 一輔, 村上 千香子, 入江 渉, 大石 桃子, 佐々木 千寿子, 中丸 尚美, 中村 茂基, 栗原 克由

    DNA多型   22 ( 1 )   121 - 123   2014.7

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  • TBONE EX KITを用いた白骨死体の個人識別

    前田 一輔, 村上 千香子, 入江 渉, 渡邉 利真, 大石 桃子, 佐々木 千寿子, 中丸 尚美, 古川 理孝, 中村 茂基, 栗原 克由, 原 正昭, 高田 綾, 齋藤 一之

    DNA多型   21   168 - 170   2013.5

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  • 心筋症の遺伝子解析 筋LIM蛋白遺伝子の変異解析

    村上 千香子, 前田 一輔, 入江 渉, 渡邉 利真, 大石 桃子, 佐々木 千寿子, 中丸 尚美, 古川 理孝, 中村 茂基, 栗原 克由

    DNA多型   21   261 - 264   2013.5

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  • DNA identification of skeletal remains by using a new extraction kit

    Kazuho Maeda, Chikako Murakami, Masaaki Hara, Wataru Irie, Momoko Oishi, Chizuko Sasaki, Shigeki Nakamura, Shirushi Takahashi, Aya Takada, Kazuyuki Saito

    Forensic Science International: Genetics Supplement Series   4 ( 1 )   2013

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  • Genetic analysis of g.7260-7291 region of ANKRD1 in Japanese population

    Shigeki Nakamura, Chikako Murakami, Kazuho Maeda, Wataru Irie, Chizuko Sasaki, Toshimasa Watanabe, Momoko Ohishi, Katsuyoshi Kurihara

    Forensic Science International: Genetics Supplement Series   4 ( 1 )   2013

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  • Mutational analysis of TTN, TCAP and TPM1 in cardiomyopathy

    Kazuho Maeda, Chikako Murakami, Wataru Irie, Momoko Oishi, Chizuko Sasaki, Naomi Nakamaru, Shigeki Nakamura, Katsuyoshi Kurihara

    Forensic Science International: Genetics Supplement Series   4 ( 1 )   2013

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  • Real-Time PCRを用いたTaqMan Probe ABO genotyping IV

    前田 一輔, 村上 千香子, 入江 渉, 渡邉 利真, 佐々木 千寿子, 中丸 尚美, 古川 理孝, 中村 茂基, 栗原 克由

    DNA多型   20   249 - 251   2012.5

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  • New rapid ABO genotyping using direct extraction kit

    Kazuho Maeda, Shigeki Nakamura, Chikako Murakami, Wataru Irie, Chizuko Sasaki, Masataka Furukawa, Katsuyoshi Kurihara

    Forensic Science International: Genetics Supplement Series   3 ( 1 )   2011.12

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  • Mutational analysis of the mitochondrial DNA detected in sudden death cases with cardiac hypertrophy

    S. Nakamura, M. Kobayashi, C. Murakami, W. Irie, K. Maeda, C. Sasaki, M. Furukawa, K. Kurihara

    Forensic Science International: Genetics Supplement Series   3 ( 1 )   2011.12

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  • Analysis of ventricular myosin light chain genes in cardiomyopathy

    Wataru Irie, Chikako Murakami, Shigeki Nakamura, Kazuho Maeda, Chizuko Sasaki, Masataka Furukawa, Katsuyoshi Kurihara

    Forensic Science International: Genetics Supplement Series   3 ( 1 )   2011.12

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  • 法科学的鑑定 Real-Time PCRを用いたTaqMan Probe ABO genotyping(II)

    前田 一輔, 村上 千香子, 入江 渉, 小林 正宗, 林 まい子, 佐々木 千寿子, 中丸 尚美, 中村 茂基, 古川 理孝, 栗原 克由

    DNA多型   19   210 - 213   2011.5

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  • DNA多型の臨床応用 心筋症に基づく突然死症例におけるmtDNA遺伝子解析

    小林 正宗, 中村 茂基, 村上 千香子, 前田 一輔, 入江 渉, 林 まい子, 佐々木 千寿子, 中丸 尚美, 古川 理孝, 栗原 克由

    DNA多型   19   250 - 254   2011.5

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  • Mitochondrial DNA coding regionの変異性の検討(I)

    小林 正宗, 中村 茂基, 村上 千香子, 前田 一輔, 入江 渉, 和田 文太, 林 まい子, 佐々木 千寿子, 中丸 尚美, 古川 理孝, 栗原 克由

    DNA多型   18   250 - 254   2010.5

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  • Real-Time PCRを用いたTaqMan Probe ABO genotyping

    前田 一輔, 中村 茂基, 村上 千香子, 小林 正宗, 入江 渉, 金子 友則, 和田 文太, 佐々木 千寿子, 中丸 尚美, 古川 理孝, 栗原 克由

    DNA多型   17   206 - 209   2009.5

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  • Analysis of AmpFlSTR<sup>®</sup> MiniFiler™ loci and its forensic application

    Shigeki Nakamura, Chikako Murakami, Kazuho Maeda, Masamune Kobayashi, Wataru Irie, Bunta Wada, Maiko Hayashi, Chizuko Sasaki, Masataka Furukawa, Katsuyoshi Kurihara

    Forensic Science International: Genetics Supplement Series   2 ( 1 )   19 - 20   2009.1

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  • Analysis of three major sarcomeric genes (MYH7, TNNT2, MYBPC3) in cardiomyopathy

    Kazuho Maeda, Shigeki Nakamura, Chikako Murakami, Masamune Kobayashi, Wataru Irie, Bunta Wada, Maiko Hayashi, Chizuko Sasaki, Masataka Furukawa, Katsuyoshi Kurihara

    Forensic Science International: Genetics Supplement Series   2 ( 1 )   499 - 500   2009.1

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  • Mitochondrial DNA analysis of human skeletal remains unearthed from Northern area of Kanagawa Prefecture, Japan

    Masamune Kobayashi, Shigeki Nakamura, Chikako Murakami, Kazuho Maeda, Wataru Irie, Bunta Wada, Maiko Hayashi, Chizuko Sasaki, Masataka Furukawa, Katsuyoshi Kurihara

    Forensic Science International: Genetics Supplement Series   2 ( 1 )   263 - 264   2009.1

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  • Analysis of mtDNA control region using mitoSEQr™ resequencing system and its forensic application

    Shigeki Nakamura, Chikako Murakami, Wataru Irie, Masamune Kobayashi, Kazuho Maeda, Chizuko Sasaki, Naomi Nakamaru, Masataka Furukawa, Katsuyoshi Kurihara

    Forensic Science International: Genetics Supplement Series   1 ( 1 )   292 - 294   2008.8

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  • 心筋症の遺伝子解析VII ミオシン結合蛋白C遺伝子の変異解析

    村上 千香子, 中村 茂基, 小林 正宗, 前田 一輔, 入江 渉, 佐々木 千寿子, 中丸 尚美, 古川 理孝

    DNA多型   16   207 - 209   2008.5

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Presentations

  • Viral Detection from Formalin-Fixed Paraffin-Embedded Tissue in Autopsy Cases of Viral Pneumonia

    Kazuho Maeda, Momoka Tanabe, Hikaru Kuninaka, Noriko Ogawa, Moe Mukai, Ayako Nasu, Chiaki Fuke, Yosuke Usumoto, Yoko Ihama

    30th Congress of the International Society for Forensic Genetics  2024.9 

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  • Genetic analysis of mtDNA mutation found in sudden death cases with cardiac hypertrophy

    Kazuho Maeda, Chikako Murakami, Wataru Irie, Chizuko Sasaki, Naomi Nakamaru, Momoko Oishi, Shigeki Nakamura, Katsuyoshi Kurihara

    9th International Symposium On ADVANCES IN LEGAL MEDICINE  2014.6 

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  • The relation between the genetic mutations of mtDNA and sudden death cases with cardiac hypertrophy

    Kazuho Maeda, Chikako Murakami, Wataru Irie, Shigeki Nakamura, Chizuko Sasaki, Momoko Oishi, Naomi Nakamaru, Katsuyoshi Kurihara

    DNA in Forensics 2012  2014.5 

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  • DNA型鑑定のみでは身元特定が不可能であった1事例

    前田一輔, 村上千香子, 入江渉, 佐々木千寿子, 大石桃子, 中丸尚美, 中村茂基, 栗原克由

    第99次日本法医学会学術全国集会  2015.6 

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  • 心筋症症例におけるタイチン遺伝子変異解析

    前田一輔, 村上千香子, 入江渉, 佐々木千寿子, 中丸尚美, 大石桃子, 中村茂基, 栗原克由

    第98次日本法医学会学術全国集会  2014.6 

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  • 蔓（かずら）による頚部圧迫で窒息死した1例

    前田一輔, 林敬人, 中前琢磨, 肥後恵理, 税所千春, 石田絢香, 小片守

    第66回日本法医学会学術九州地方集会  2016.10 

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  • The case of 2 siblings that identified not only by DNA profiling

    Kazuho Maeda, Chikako Murakami, Wataru Irie, Chizuko Sasaki, Momoko Oishi, Naomi Nakamaru, Shigeki Nakamura, Katsuyoshi Kurihara

    26th International Congress of the International Society for Forensic Genetics  2015.9 

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  • 心筋症及び心肥大・拡張例における心臓特異的骨形成蛋白質10及びRNA binding motif protein 20遺伝子変異解析

    前田一輔, 村上千香子, 入江渉, 佐々木千寿子, 佐藤文子, 栗原克由

    第101次日本法医学会学術全国集会  2017.6 

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  • 心筋症及び心肥大・拡張事例におけるラミンA/C遺伝子およびサイファー遺伝子の変異解析

    前田一輔, 村上千香子, 入江渉, 佐々木千寿子, 中村茂基, 佐藤文子, 栗原克由

    第66回日本法医学会学術九州地方集会  2016.10 

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  • Investigating miRNA as potential biomarker for diagnosis of drowning

    Kazuho Maeda, Takahito Hayashi, Takuma Nakamae, Eri Higo, Mamoru Ogata

    10th International Symposium Advances in Legal Medicine combined with the 96th Annual Conference German Society of Legal Medicine  2017.9 

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  • Mutational analysis of LDB3 in sudden death cases with cardiomyopathy or cardiac hypertrophy

    Kazuho Maeda, Chikako Murakami, Wataru Irie, Chizuko Sasaki, Fumiko Sato, Katsuyoshi Kurihara

    10th International Symposium Advances in Legal Medicine combined with the 96th Annual Conference German Society of Legal Medicine  2017.9 

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  • Viral load and infectivity of SARS-CoV-2 in COVID-19 corpses Invited

    Kazuho Maeda, Yoko Ihama

    第108次日本法医学学術全国集会  2024.6 

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    Presentation type：Symposium, workshop panel (nominated)  

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  • 心筋症の遺伝子解析XIV -テレトニンおよびタイチン遺伝子の変異解析-

    前田一輔, 村上千香子, 入江渉, 大石桃子, 佐々木千寿子, 中丸尚美, 中村茂基, 栗原克由

    第97次日本法医学会学術全国集会  2013.7 

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  • 日本人集団における心アンキリン反復蛋白遺伝子g.7260_7291領域の遺伝子多型解析

    前田一輔, 村上千香子, 入江渉, 大石桃子, 佐々木千寿子, 中丸尚美, 中村茂基, 栗原克由

    第82回日本法医学会学術関東地方集会  2013.10 

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  • DNA identification of skeletal remains by using a new extraction kit

    Kazuho Maeda, Chikako Murakami, Masaaki Hara, Wataru Irie, Momoko Oishi, Chizuko Sasaki, Shigeki Nakamura, Shirushi Takahashi, Aya Takada, Kazuyuki Saito

    25th International Congress of the International Society for Forensic Genetics  2013.9 

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  • ANKRD1のg.7260_7291領域における個人識別への応用

    前田一輔, 村上千香子, 入江渉, 大石桃子, 佐々木千寿子, 中丸尚美, 中村茂基, 栗原克由

    日本DNA多型学会第22回学術集会  2013.11 

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  • 鼻口部のみにガムテープを貼り窒息死した一剖検例

    前田一輔, 入江渉, 村上千香子, 大石桃子, 佐々木千寿子, 中丸尚美, 中村茂基, 栗原克由

    第63回日本法医学会九州地方会  2013.10 

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  • Real-Time PCRを用いたTaqMan Probe ABO genotyping

    前田 一輔, 中村 茂基, 村上 千香子, 小林 正宗, 入江 渉, 金子 友則, 和田 文太, 佐々木 千寿子, 中丸 尚美, 古川 理孝, 栗原 克由

    日本DNA多型学会第17回学術集会  2008.11 

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  • 心筋症の遺伝子解析(VIII) ミオシン結合蛋白C遺伝子の変異解析

    前田 一輔, 中村 茂基, 小林 正宗, 村上 千香子, 入江 渉, 佐々木 千寿子, 中丸 尚美, 古川 理孝, 栗原 克由

    第92次日本法医学会総会  2008.4 

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  • A rare autopsy case of asphyxia due to neck compression by a climbing plant, “KAZURA”

    Kazuho Maeda, Takahito Hayashi, Takuma Nakamae, Eri Higo, Mamoru Ogata

    10th International Symposium Advances in Legal Medicine combined with the 96th Annual Conference German Society of Legal Medicine  2017.9 

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  • A potential diagnostic marker for the differentiation between freshwater and saltwater drowning: Intrapulmonary AQP5-related micro RNA

    Kazuho Maeda, Takahito Hayashi, Takuma Nakamae, Eri Higo, Mamoru Ogata

    The 24th Congress of the International Academy of Legal Medicine  2018.6 

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  • 淡水溺死と海水溺死の鑑別に有用なmiRNA探索

    前田一輔, 林 敬人, 中前琢磨, 肥後恵理, 小片 守

    第67回日本法医学会学術九州地方集会  2017.11 

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  • 淡水溺死と海水溺死の鑑別診断に有用な新規分子マーカーの検索

    前田一輔, 林 敬人, 中前琢磨, 肥後恵理, 小片 守

    第103次日本法医学会学術全国集会  2019.6 

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  • Transient receptor potential vanilloid 4 (TRPV4)発現変化に基づく淡水溺死と海水溺死の鑑別診断について

    前田一輔, 林 敬人, 中前琢磨, 肥後恵理, 小片 守

    第68回日本法医学会学術九州地方集会  2018.10 

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  • 遺体表面からのSARS-CoV-2の検出とウイルスの感染性についての検討

    前田一輔, 田邊桃佳, 國中 光, 向井 萌, 那須亜矢子, 臼元洋介, 福家千昭, 井濱容子

    第90回日本法医学会学術関東地方集会  2021.10 

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  • 育児をしながら夫婦でキャリア形成をしていくために

    前田一輔

    第104次日本法医学会学術全国集会  2020.9 

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  • SARS-CoV-2陽性死体の表面および検体の感染リスクについて

    前田一輔, 臼元洋介, 田邊桃佳, 國中 光, 小川典子, 加藤雄也, 向井 萌, 那須亜矢子, 福家千昭, 井濱容子

    日本DNA多型学会第31回学術集会  2022.11 

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  • 死体外表および検体中のSARS-CoV-2の感染性について

    前田一輔, 臼元洋介, 田邊桃佳, 國中 光, 向井 萌, 那須亜矢子, 福家千昭, 井濱容子

    第106次日本法医学会学術全国集会  2022.6 

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  • Risk of infection from COVID-19 corpse surfaces and the specimens Invited

    Kazuho Maeda

    Wakayama Medical University International Symposium -Forensic Medicine-  2023.3 

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  • TaqMan Probe法を用いた日本人集団におけるABO遺伝子型解析

    前田一輔, 村上千香子, 入江渉, 渡邉利真, 佐々木千寿子, 中丸尚美, 古川理孝, 中村茂基, 栗原克由

    第96次日本法医学会学術全国集会  2012.6 

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  • Real-Time PCRを用いたTaqMan Probe ABO genotypingⅣ

    前田 一輔, 村上千香子, 入江渉, 渡邉利真, 佐々木千寿子, 中丸尚美, 古川理孝, 中村茂基, 栗原克由

    日本DNA多型学会第20回学術集会  2011.12 

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  • TBONE EX KITを用いた白骨死体の個人識別

    前田一輔, 村上千香子, 入江渉, 渡邉利真, 大石桃子, 佐々木千寿子, 中丸尚美, 古川理孝, 中村茂基, 原正昭, 高田綾, 齋藤一之, 栗原克由

    日本DNA多型学会第21回学術集会  2012.11 

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  • 内因性の肝臓破裂による死亡を疑われた事例

    前田 一輔, 入江 渉, 村上 千香子, 渡邉 利真, 大石 桃子, 佐々木 千寿子, 中丸 尚美, 中村 茂基, 古川 理孝, 栗原 克由

    第81回日本法医学会学術関東地方集会  2012.10 

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  • 尖器と刺創形態に関する一考察

    前田一輔, 古川理孝, 入江渉, 村上千香子, 小林正宗, 中丸尚美, 佐々木千寿子, 和田文太, 林まい子, 中村茂基, 栗原克由

    第59回日本法医学会九州地方会  2009.10 

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  • Analysis of three major sarcomeric genes (MYH7, TNNT2, MYBPC3) in cardiomyopathy

    Kazuho Maeda, Shigeki Nakamura, Chikako Murakami, Masamune Kobayashi, Wataru Irie, Bunta Wada, Maiko Hayashi, Chizuko Sasaki, Masataka Furukawa, Katsuyoshi Kurihara

    2009.9 

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  • Real-Time PCRを用いたTaqMan Probe ABO genotypingⅡ

    前田 一輔, 村上 千香子, 入江 渉, 小林 正宗, 林 まい子, 佐々木 千寿子, 中丸 尚美, 中村 茂基, 古川 理孝, 栗原 克由

    日本DNA多型学会第19回学術集会  2010.11 

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  • 結束バンドを用いた特異的な自絞死3例

    前田 一輔, 入江 渉, 村上 千香子, 小林 正宗, 林 まい子, 中丸 尚美, 佐々木 千寿子, 中村 茂基, 古川 理孝, 栗原 克由

    第79回日本法医学会学術関東地方集会  2010.10 

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  • New rapid ABO genotyping using direct extraction kit

    Kazuho Maeda, Shigeki Nakamura, Chikako Murakami, Wataru Irie, Chizuko Sasaki, Masataka Furukawa, Katsuyoshi Kurihara

    2011.9 

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  • ホルマリン固定したパラフィン包埋組織からのウイルス検出

    前田一輔, 臼元洋介, 田邊桃佳, 國中 光, 小川典子, 加藤雄也, 向井 萌, 那須亜矢子, 福家千昭, 井濱容子

    第107次日本法医学会学術全国集会  2023.6 

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  • Real-Time PCRを用いたTaqMan Probe ABO genotypingⅢ

    前田一輔, 村上千香子, 入江渉, 小林正宗, 林まい子, 佐々木千寿子, 中丸尚美, 古川理孝, 中村茂基, 栗原克由

    第95次日本法医学会学術全国集会  2011.6 

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  • 血清中から新型コロナウイルスが検出されたRNAemiaに関連する因子について

    前田一輔, 臼元洋介, 田邊桃佳, 國中光, 向井 萌, 那須亜矢子, 永井智紀, 福家千昭, 井濱容子

    第107次日本法医学会学術全国集会  2023.6 

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  • 自作調理器具による後頚部杙創で死亡した一剖検例

    前田一輔, 入江 渉, 村上千香子, 渡邉利真, 佐々木千寿子, 中丸尚美, 中村茂基, 古川理孝, 栗原克由

    第80回日本法医学会学術関東地方集会  2011.10 

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  • Mutational analysis of TTN, TCAP and TPM1 in cardiomyopathy

    Kazuho Maeda, Chikako Murakami, Wataru Irie, Momoko Oishi, Chizuko Sasaki, Naomi Nakamaru, Shigeki Nakamura, Katsuyoshi Kurihara

    25th International Congress of the International Society for Forensic Genetics  2013.9 

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Awards

  • 日本法医病理学会若手研究助成 2023

    2023   日本法医病理学会  

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  • 第11回桜ヶ丘地区基礎系研究発表会プレゼンテーション賞

    2018   鹿児島大学  

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  • 10th ISALM若手研究助成

    2017   日本法医病理学会  

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  • 優秀学位論文賞

    2013   北里大学大学院医療系研究科  

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  • Student Research Day ベストポスター賞

    2012   北里大学大学院医療系研究科  

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Research Projects

  • Interprofessional work and career paths in forensic Medicine

    Grant number：24IA1014  2024.4 - 2027.3

    Yoko Ihama, Sohtaro Mimasaka, Takuma Yamamoto, Tadashi Ogawa, Takahiro Umehara, Aya Matsusue, Ako Sasao, Kazuho Maeda

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  • マルチオミクス解析による乳幼児および小児突然死の死亡リスク予測モデルの開発

    Grant number：24K02720  2024.4 - 2027.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    前田 一輔

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    Authorship：Principal investigator 

    Grant amount：\18590000 （ Direct Cost: \14300000 、 Indirect Cost：\4290000 ）

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  • Comprehensive genetic analysis of pulmonary and vascular endothelial cells in decompression injury during diving.

    Grant number：24K13547  2024.4 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • A potential diagnostic marker for the drowning by investigating intrapulmonary mRNA and miRNA

    Grant number：19K19487  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists  Grant-in-Aid for Early-Career Scientists

    MAEDA Kazuho

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    The diagnosis of drowning is one of the difficult problems in forensic science. In this study, we investigated a diagnostic marker for drowning, focused on intrapulmonary mRNA and miRNA. In the animal experiments, the expression of aqp5 was reduced and trpv4 was increased in freshwater drowning (FWD) significantly compared with that in saltwater drowning (SWD) and control mice. The miR-185-3p was predicted to bind to aqp5 and its expression was increased significantly in FWD. Consistent with the results in animals, a significant decrease of aqp5 and an increase of trpv4 and miR-185-3p expression was observed in FWD autopsy cases. Due to their small size, miRNAs are less susceptible to postmortem degradation than mRNA. Accordingly, the investigation of intrapulmonary miR-185-3p expression may differentiate between FWD and SWD.

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  • Mutational analysis of disease causing gene in sudden death cases with cardiomyopathy or cardiac hypertrophy

    Grant number：15K19276  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Maeda Kazuho

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    Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）

    We performed comprehensive genetic analysis of genes that would cause dilated cardiomyopathy (DCM) in sudden death with cardiomyopathies or concentric/dilatation hypertrophy. DCM-associated mutation was detected from one HCM case in LDB3 and other HCM case in RBM20. These HCM cases also had a mutation associated with HCM in other gene. In addition, a novel mutation was detected from one concentric hypertrophy case in RBM20. This mutation was located near to the mutation associated with HCM. These results suggested that multiple gene mutations associated with each cardiomyopathy would exacerbate cardiac function and RBM20 might be not only as DCM-causing gene but also as HCM-causing gene. Further investigation using more postmortem samples is need for proving this hypothesis and elucidating the molecular mechanism in the onset of cardiomyopathy.

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  • Mutational analysis of the disease causing genes in sudden cardiac death diagnosed as cardiomyopathy

    Grant number：23590856  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    NAKAMURA SHIGEKI, KURIHARA Katsuyoshi, FURUKAWA Masataka, MURAKAMI Chikako, IRIE Wataru, MAEDA Kazuho

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    Grant amount：\5330000 （ Direct Cost: \4100000 、 Indirect Cost：\1230000 ）

    Comprehensive screening of ANKRD1 (cardiac ankyrin repeat protein), TCAP (telethonin) and TTN (titin) was performed in consented autopsy cases diagnosed as cardiomyopathies (CMs), in order to evaluate the prevalence of gene mutations in sudden cardiac death caused by CMs. A total of 26 mutations including 3 missense mutations was detected in DCM cases. Our results suggested that the mutations might alter interaction of the Z-disc and N2A components and caused DCM. It was indicated that genetic analysis of these three genes was useful to decide diagnosis of CMs for forensic autopsy cases.

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  • Mutational analysis of the mitochondrial DNA detected in sudden cardiac death caused by cardiomyopathy

    Grant number：20590685  2008 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    NAKAMURA Shigeki, MURAKAMI Chikako, FURUKAWA Masataka, KURIHARA Katsuyoshi, IRIE Wataru, KOBAYASHI Masamune, MAEDA Kazuho

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

    Comprehensive screening of Mitochondrial DNA (mtDNA) was performed in consented autopsy cases diagnosed as cardiomyopathies (CMs), in order to evaluate the prevalence of gene mutations in sudden cardiac death caused by CMs. Our result suggested that missense mutations were detected in 42% of DCM cases and in 20% of HCM cases. It was indicated that genetic analysis of mtDNA was useful to decide diagnosis of CM for forensic autopsy cases.

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