Updated on 2025/04/30

写真a

 
Takashi Ohya
 
Organization
Graduate School of Medicine Department of Medicine Oral and Maxillofacial Surgery Assistant Professor
School of Medicine Medical Course
Title
Assistant Professor
Profile

研究の専門領域は、生体医工学、医用工学です。横浜市立大学医学研究科に在職しており学位は博士（医学）です。東京大学工学系研究科の特別研究学生、協力研究員、特任研究員としての研究歴もあり、その経験を活かしあらゆる疾患の低侵襲で確実な診断法、治療法、予防法の確立を目指しています。医工連携を推進し、新しい医療機器システム開発にも日々取り組んでいます。臨床では口腔癌、顎顔面インプラント、外傷をはじめ歯科口腔外科全般の治療を行っています。

External link

Degree

  • 博士（医学） ( 横浜市立大学 )

Research Interests

  • 画像解析

  • 可視化

  • 生体医工学

  • Biomedical Engineering

  • 医用工学

  • 低侵襲手術

Research Areas

  • Life Science / Medical systems

Research History

  • 横浜市立大学医学部口腔外科学 助教，先端医科学研究センター感染症標的コアユニット長

    2024.4

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  • 横浜市立大学医学部口腔外科学 助教 兼 臨床研究管理員，次世代臨床研究センター臨床研究指導員，先端医科学研究センター感染症標的コアユニット長

    2023.4 - 2024.3

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  • 横浜市立大学医学部口腔外科学 助教 兼 臨床研究管理員，次世代臨床研究センター臨床研究指導員

    2022.10 - 2023.3

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  • 横浜市立大学医学部口腔外科学 助教 兼 次世代臨床研究センター臨床研究指導員

    2022.4 - 2022.9

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  • 横浜市立大学 医学部口腔外科学 助教 兼 感染制御部

    2020.4 - 2022.3

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  • Yokohama City University

    2018.4 - 2020.3

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  • Yokohama City University   Assistant Professor

    2017.4 - 2018.3

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  • Yokohama City University   Hospital, Dentistry/Oral and Maxillofacial Surgery/Orthodontics

    2015.6 - 2017.3

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  • 国家公務員共済組合連合会 横浜栄共済病院   歯科口腔外科   医員

    2014.4 - 2015.5

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  • The University of Tokyo   The Graduate School of Engineering

    2013.4 - 2014.3

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  • Yokohama City University   Hospital, Dentistry/Oral and Maxillofacial Surgery/Orthodontics

    2013.4 - 2014.3

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  • The University of Tokyo   The Graduate School of Engineering

    2011.12 - 2012.11

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  • The University of Tokyo   The Graduate School of Engineering

    2009.11 - 2011.10

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  • Yokohama City University   Graduate School of Medicine, Graduate

    2009.4 - 2013.3

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  • 公立豊岡病院組合立豊岡病院   歯科口腔外科   専修医

    2008.4 - 2009.3

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  • 公立豊岡病院組合立豊岡病院   歯科口腔外科   臨床研修医

    2007.10 - 2008.3

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  • Kyoto University   Oral and Maxillofacial Surgery, Hospital

    2007.4 - 2007.9

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Professional Memberships

  • 国公立大学附属病院感染対策協議会

    2020.4

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  • 日本顎変形症学会

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  • JAPANESE SOCIETY OF ORAL AND MAXILLOFACIAL SURGEONS

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  • 日本口腔診断学会

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  • THE JAPAN SOCIETY OF COMPUTER AIDED SURGERY

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  • Japanese Society of Oral Oncology

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  • JAPANESE SOCIETY OF DENTISTRY FOR MEDICALLY COMPROMISED PATIENT

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  • 日本顎顔面インプラント学会

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Committee Memberships

  • 一般社団法人 日本コンピュータ外科学会   評議員  

    2021.11   

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    Committee type：Academic society

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  • 一般社団法人 日本コンピュータ外科学会   評議員  

    2017.10 - 2019.10   

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    Committee type：Academic society

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Papers

  • Correlation between condylar repositioning, resorption, and mandibular relapse post-orthognathic surgery with the straight locking miniplate technique in patients with Class II and III malocclusion: a retrospective study Reviewed

    Umezawa H., Takasu H., Ohya T., Yamashita Y., Hirota M., Mitsudo K.

    International Journal of Oral & Maxillofacial Surgery   2025.2

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  • 舌癌に対する逆行性超選択的動注化学放射線療法119例における栄養摂取状況の分析 Reviewed

    大屋貴志, 陳雪霏, 石川聡一郎, 竹田敦, 大橋伸英, 林雄一郎, 小栗千里, 小泉敏之, 來生知, 光藤健司

    日本口腔外科学会雑誌   70 ( 8 )   327 - 335   2024.8

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    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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  • Design consideration on integration of mechanical intravascular ultrasound and electromagnetic tracking sensor for intravascular reconstruction Reviewed

    Wenran Cai, Kazuaki Hara, Naoki Tomii, Etsuko Kobayashi, Takashi Ohya, Ichiro Sakuma

    International Journal of Computer Assisted Radiology and Surgery   2024.1

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Purpose

    Considering vessel deformation, endovascular navigation requires intraoperative geometric information. Mechanical intravascular ultrasound (IVUS) with an electromagnetic (EM) sensor can be used to reconstruct blood vessels with thin diameter. However, the integration design should be evaluated based on the factors affecting the reconstruction error.

    Methods

    The interference between the mechanical IVUS and EM sensor was measured in different relative positions. Two designs of the integrated catheter were evaluated by measuring the reconstruction errors using a rigid vascular phantom.

    Results

    When the distance from the EM sensor to the field generator was 75 mm, the interference from mechanical IVUS to an EM sensor was negligible, with position and rotation errors less than 0.1 mm and 0.6°, respectively. The reconstructed vessel model for proximal IVUS transducer had a smooth surface but an inaccurate shape at large curvature of the vascular phantom. When the distance to the field generator was 175 mm, the error increased significantly.

    Conclusion

    Placing the IVUS transducer on the proximal side of the EM sensor is superior in terms of interference reduction but inferior in terms of mechanical stability compared to a distal transducer. The distal side is preferred due to better mechanical stability during catheter manipulation at larger curvature. With this configuration, surface reconstruction errors less than 1.7 mm (with RMS 0.57 mm) were achieved when the distance to the field generator was less than 175 mm.

    DOI： 10.1007/s11548-024-03059-5

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    Other Link： https://link.springer.com/article/10.1007/s11548-024-03059-5/fulltext.html

  • Diameters of lingual, facial, and maxillary arteries measured according to an objective protocol on 3D computed tomography angiography images. Reviewed International journal

    Takashi Ohya, Ichiro Sakuma, Wenran Cai, Etsuko Kobayashi, Toshiyuki Koizumi, Kenji Mitsudo

    International journal of computer assisted radiology and surgery   2023.7

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: Retrograde superselective intra-arterial chemoradiotherapy is a radical treatment for advanced oral cancer. The catheter tip is placed into tumor-feeding arteries-the lingual, facial, or maxillary arteries. The diameter of the tumor-feeding arteries newly bifurcated from the external carotid artery is crucial for determining the requirement of a catheter navigation system. This study aimed to measure the diameter and distribution of the tumor-feeding artery according to an objective protocol using 3D computed tomography angiography images reproducibly. METHODS: Angiographic data of 20 noncatheterized carotid arteriesof 10 randomly selected patients were analyzed. We followed the external carotid artery to the entrance of each feeding artery to determine the center point where the artery diameter was measured. The diameter of the optimum circle measured at the adopted center point was taken as the diameter of each tumor-feeding artery. RESULTS: The diameters (mean ± standard deviation) were 3.5 ± 0.45, 2.9 ± 0.56, and 3.5 ± 0.56 mm for the maxillary, lingual, and facial arteries, respectively. The diameters of the maxillary and facial arteries were similar (p = 0.877), whereas the diameter of the lingual artery was smaller than that of the maxillary and facial arteries (p < 0.001). CONCLUSION: The findings of this study will be beneficial in determining the need of a new catheter navigation system and diameter of catheters to be used in the clinical practice. From the viewpoint of measurement automation and reproducibility, 3DCTA vessel measurement taken according to the proposed protocol was considered to be effective.

    DOI： 10.1007/s11548-023-02992-1

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  • 骨格性上顎前突および骨格性下顎前突患者における上下顎骨形成術後の下顎頭の比較

    梅澤 ひみこ, 高須 曜, 大屋 貴志, 宮城島 弘貴, 今井 治樹, 山下 陽介, 藤田 紘一, 村田 彰吾, 大村 進, 廣田 誠, 光藤 健司

    日本顎変形症学会雑誌   33 ( 2 )   145 - 145   2023.5

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    Language：Japanese   Publisher：(NPO)日本顎変形症学会  

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  • 下顎歯肉扁平上皮癌T4症例における手術療法と術前超選択的動注化学放射線療法の比較検討

    小栗 千里, 南山 周平, 北島 大朗, 矢島 康治, 大屋 貴志, 小泉 敏之, 岩井 俊憲, 來生 知, 光藤 健司

    頭頸部癌   49 ( 2 )   212 - 212   2023.5

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    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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  • 局所進行口腔癌に対する新規治療戦略 進行舌癌に対する逆行性超選択的動注化学放射線療法の治療効果および食事摂取状況の評価

    光藤 健司, 大屋 貴志

    頭頸部癌   49 ( 2 )   55 - 55   2023.5

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    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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  • A pilot study on an electromagnetic tracking system using tunneling magnetoresistance (TMR) sensors applicable to a 4F catheter (1.4 mm in diameter) Reviewed

    Rina Nagano, Kazuaki Hara, Etsuko Kobayashi, Takashi Ohya, Ichiro Sakuma

    International Journal of Computer Assisted Radiology and Surgery   2022.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1007/s11548-022-02746-5

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    Other Link： https://link.springer.com/article/10.1007/s11548-022-02746-5/fulltext.html

  • 局所進行下顎歯肉癌における下顎骨離断症例に対する下唇非切開による原発切除の検討 Reviewed

    小栗 千里, 南山 周平, 大屋 貴志, 矢島 康治, 岩井 俊憲, 小泉 敏之, 來生 知, 光藤 健司

    頭頸部癌   48 ( 2 )   216 - 216   2022.5

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    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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  • Visualization of droplets produced by dental air turbines that require infection control measured during coronavirus 2019 outbreaks Reviewed

    Takashi Ohya, Keiichi Nakagawa, Yasuhiro Arai, Hideaki Kato

    J Hosp Infect   2021.10

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    Authorship：Lead author,　Corresponding author   Language：English  

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  • Visualization of droplet spread produced by a nebuliser during the COVID-19 pandemic Reviewed

    Hideaki Kato, Takashi Ohya, Yasuhiro Arai, Keiichi Nakagawa

    QJM: An International Journal of Medicine   2021.6

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  • Applicability of a single camera-based catheter navigation system using teeth arch as an anatomical landmark for superselective intraarterial infusion in advanced oral cancer treatment Reviewed International journal

    Ken Yanagida, Takashi Ohya, Junchen Wang, Toshinori Iwai, Toshiharu Izumi, Etsuko Kobayashi, Ichiro Sakuma, Kenji Mitsudo

    Medical & Biological Engineering & Computing   59 ( 3 )   663 - 672   2021.2

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Superselective intraarterial infusion chemoradiotherapy is a modality of oral cancer therapy in which the artery feeding the tumor is catheterized. 3D information about the carotid artery is required to enable the surgeon to judge whether to advance, retract, or rotate the catheter. For this purpose, we proposed and conducted a model experiment to assess a new method of catheterization that applies a tracking system using registration with a monocular camera using the maxillary arch as the anatomical landmark. In this method, the preoperative 3D computer tomography angiographic image of the carotid artery that the catheter will be passed through is overlaid on the 2D video image. The mean TRE was 0.96 ± 0.36 mm and 0.88 ± 0.31 mm and 1.12 ± 0.46 mm when images were registered with the anterior and posterior teeth as the landmarks, respectively; the difference was not significant (p = 0.21). This tracking system that enables markerless registration simply by taking images of the maxillary anterior teeth with a single camera was convenient and effective for catheterization. In this study, we propose the new application of this tracking system and a novel method of catheterization for superselective intraarterial infusion chemoradiotherapy for oral cancer. In retrograde superselective intraarterial catheterization, a catheter is inserted into a tumor-feeding artery originating from the external carotid artery (ECA) (the lingual artery [LA], facial artery [FA], or maxillary artery [MA]). Because the maxillary dentition is located near the external carotid artery, we focused on real-time markerless registration using maxillary dentition fixed to the skull.

    DOI： 10.1007/s11517-021-02326-w

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  • 下顎歯肉癌の下顎骨離断症例における下唇非切開による原発切除の検討

    小栗 千里, 矢谷 実英, 杉山 聡美, 小杉 泰史, 林 雄一郎, 大橋 伸英, 馬場 隼一, 矢島 康治, 大屋 貴志, 岩井 俊憲, 小泉 敏之, 來生 知, 光藤 健司

    頭頸部癌   46 ( 2 )   194 - 194   2020.7

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  • Prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma treated by intra-arterial infusion chemotherapy concurrent with radiotherapy. Reviewed International journal

    Yuichiro Hayashi, Kohei Osawa, Rina Nakakaji, Shuhei Minamiyama, Nobuhide Ohashi, Takashi Ohya, Masaki Iida, Toshinori Iwai, Tomomichi Ozawa, Senri Oguri, Toshiyuki Koizumi, Makoto Hirota, Mitomu Kioi, Masaharu Hata, Kenji Mitsudo

    Head & neck   41 ( 6 )   1777 - 1784   2019.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: The aim of this study was to evaluate the prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma (SCC) treated with intra-arterial infusion chemotherapy concurrent with radiotherapy. METHODS: A total of 46 patients were reviewed retrospectively in this study. The treatment schedule comprised intra-arterial chemotherapy (total, 60 mg/m2 docetaxel and 150 mg/m2 cisplatin) and three-dimensional computed tomography based, daily conventional radiotherapy (total, 60 Gy/30 fr) for 6 weeks. RESULTS: The median follow-up period was 40 months (range, 3-110 months). The 3-year overall survival and locoregional control rates for all patients were 64.3% and 84.3%, respectively. The OS rate of the patients with N0-1 was significantly higher than that of the patients with N ≥ 2 (P < .05). No grade 5 toxicities were observed. CONCLUSIONS: Intra-arterial infusion chemotherapy concurrent with radiotherapy was effective for advanced maxillary gingival SCC.

    DOI： 10.1002/hed.25607

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  • Retrograde superselective intra-arterial chemoradiotherapy for squamous cell carcinoma of the buccal mucosa Reviewed

    Koizumi T, Minamiyama S, Hayashi Y, Osawa K, Ohashi N, Ohya T, Iida M, Iwai T, Oguri S, Hirota M, Kioi M, Mitsudo K

    Int J Radiat Res   17 ( 2 )   283 - 291   2019.4

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  • サージカルテンプレートがインプラント二次手術に有効であった3例 Reviewed

    廣田 誠, 馬場 隼一, 北島 大朗, 大屋 貴志, 岩井 俊憲, 光藤 健司

    Japanese Journal of Maxillo Facial Implants   17 ( 3 )   275 - 275   2018.11

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    Language：Japanese   Publisher：(公社)日本顎顔面インプラント学会  

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  • Application of Medical Imaging Technology in Oral and Maxillofacial Surgery Reviewed

    Ohya T, Sakuma I, Mitsudo K

    9 ( 2 )   2018.9

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  • Daily Cisplatin and Weekly Docetaxel versus Weekly Cisplatin Intra-Arterial Chemoradiotherapy for Late T2-3 Tongue Cancer: A Pilot and Feasibility Trial. International journal

    Yuichiro Hayashi, Shuhei Minamiyama, Takashi Ohya, Masaki Iida, Toshinori Iwai, Toshiyuki Koizumi, Senri Oguri, Makoto Hirota, Mitomu Kioi, Masaharu Hata, Masataka Taguri, Kenji Mitsudo

    Medicina (Kaunas, Lithuania)   54 ( 4 )   2018.7

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    Background and objectives: The aim of present study was to compare the treatment results of daily cisplatin (CDDP), weekly docetaxel (DOC) intra-arterial infusion chemotherapy combined with radiotherapy (DIACRT) regimen and weekly CDDP intra-arterial infusion chemotherapy combined with radiotherapy (WIACRT) for patients with tongue cancer. Materials and Methods: Between January 2007 and December 2016, a total of 11 patients treated with WIACRT and 45 patients treated with DIACRT were enrolled in the present study. In the DIACRT group, 25 patients had late T2, and 20 patients had T3. A total of nine patients had late T2 and two had T3 in WIACRT (p = NS). In DIACRT, the treatment schedule consisted of intra-arterial chemotherapy (DOC, total 60 mg/m²; CDDP, total 150 mg/m²) and daily concurrent radiotherapy (RT) (total, 60 Gy). In WIACRT, the treatment schedule consisted of intra-arterial chemotherapy (CDDP, total 360 mg/m²) and daily concurrent RT (total, 60 Gy). Results: The median follow-up periods for DIACRT and WIACRT were 61 and 66 months, respectively. The five-year local control (LC) and overall survival (OS) rate were 94.5% and 89.6% for the DIACRT group, and 60.6% and 63.6% for the WIACRT group, respectively. The LC rate and OS of the DIACRT group were significantly higher than those of the WIACRT group. As regards toxicities, no treatment-related deaths were observed during the follow-up periods in both groups. Conclusions: DIACRT was found to be feasible and effective for patients with tongue cancer and could become a new treatment modality.

    DOI： 10.3390/medicina54040052

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  • Weekly cisplatin and weekly docetaxel versus weekly cisplatin intra-arterial chemoradiotherapy for late T2-3 tongue cancer: a pilot and feasibility trial Reviewed

    Hayashi Y, Minamiyama S, Ohya T, Iida M, Iwai T, Koizumi T, Oguri S, Hirota M, Kioi M, Hata M, Taguri M, Mitsudo K

    Medicina   54 ( 4 )   52   2018.5

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  • 後期高齢者の進行口腔癌に対する逆行性超選択的動注化学放射線療法

    光藤 健司, 林 雄一郎, 南山 周平, 馬場 隼一, 大橋 伸英, 大屋 貴志, 飯田 昌樹, 岩井 俊憲, 小栗 千里, 小泉 敏之, 廣田 誠, 來生 知, 藤内 祝

    日本癌治療学会学術集会抄録集   55回   P156 - 5   2017.10

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    Language：Japanese   Publisher：(一社)日本癌治療学会  

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  • Giant sialolith of the submandibular gland Reviewed

    Toshinori Iwai, Toshiharu Izumi, Takashi Ohya, Senri Oguri, Iwai Tohnai

    Journal of Clinical and Diagnostic Research   11 ( 8 )   ZJ03 - ZJ04   2017.8

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Clinical and Diagnostic Research  

    DOI： 10.7860/JCDR/2017/29383.10391

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  • 重症口腔粘膜炎による口腔内出血が原因で心肺停止となった造血幹細胞移植の1例

    大橋 伸英, 柳田 健, 大久保 牧子, 大屋 貴志, 岡本 喜之, 筑丸 寛, 廣田 誠, 來生 知, 光藤 健司, 藤内 祝

    日本口腔ケア学会雑誌   11 ( 3 )   235 - 235   2017.4

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  • Accuracy Evaluation of the Catheter Navigation System assisting Superselective intra-arterial infusion for Oral Cancer Treatment

    Yanagida Ken, Ohya Takashi, Wang Junchen, Nakamura Ryosuke, Murata Rintaro, Kobayashi Etsuko, Sakuma Ichiro, Tohnai Iwai

    Transactions of Japanese Society for Medical and Biological Engineering   54 ( 26 )   S88 - S88   2016

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    Language：Japanese   Publisher：Japanese Society for Medical and Biological Engineering  

    <p>Superselective intra-arterial infusion for oral cancer has a high anti-cancer effect. Images made by preoperative computed tomography angiography(CTA) and intraoperative digital subtraction angiography(DSA) guide placement of a catheter, which remains in the target artery. However, only these images sometimes cannot help surgeons perform the difficult catheterization. In this report, we present a novel navigation system. This system detected patient's position and orientation by gradient information of maxilla-dental-arch and performed registration by three dimensional CTA image. We made a phantom based on CTA data and we evaluated target registration error(TRE). Measurement device was the optical tracker(NDI Polaris). To evaluate accuracy by the model, the dodecahedron with 1mm hole on each surface was made on the artery bifurcation. At the lingual-facial artery, TRE was satisfied the requirement in one case, this system suggested possibility of adaptation to the superselective intra-arterial infusion.</p>

    DOI： 10.11239/jsmbe.54Annual.S88

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  • 当科における進行および再発・転移口腔癌に対するcetuximabの使用経験

    來生 知, 中島 英行, 飯田 昌樹, 柴崎 麻衣子, 大原 良仁, 大屋 貴志, 大橋 伸英, 岩井 俊憲, 小栗 千里, 光藤 健司, 藤内 祝

    日本口腔科学会雑誌   63 ( 4 )   348 - 348   2014.9

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  • Stage III、IV口腔癌に対する逆行性超選択的動注化学放射線療法

    光藤 健司, 小泉 敏之, 大屋 貴志, 飯田 昌樹, 岩井 俊憲, 中島 英行, 小栗 千里, 來生 知, 廣田 誠, 藤内 祝

    日本癌治療学会誌   49 ( 3 )   1056 - 1056   2014.6

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  • 進行口腔癌に対する逆行性超選択的動注化学放射線療法は頸部リンパ節転移に有効か?

    光藤 健司, 小泉 敏之, 飯田 昌樹, 大屋 貴志, 岩井 俊憲, 中島 英行, 小栗 千里, 來生 知, 廣田 誠, 藤内 祝

    頭頸部癌   40 ( 2 )   217 - 217   2014.5

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  • 歯原性幻影細胞癌に対し陽子線併用動注化学療法を施行した1例

    大屋 貴志, 中島 英行, 廣田 誠, 來生 知, 光藤 健司, 高山 香名子, 高田 彰憲, 中村 達也, 不破 信和, 藤内 祝

    日本口腔科学会雑誌   63 ( 2 )   237 - 237   2014.3

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  • Cervicofacial subcutaneous emphysema associated with dental laser treatment. Reviewed International journal

    S Mitsunaga, T Iwai, H Kitajima, Y Yajima, T Ohya, M Hirota, K Mitsudo, N Aoki, Y Yamashita, S Omura, I Tohnai

    Australian dental journal   58 ( 4 )   424 - 7   2013.12

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    Cervicofacial subcutaneous emphysema is a rare complication of dental procedures. Although most cases of emphysema occur incidentally with the use of a high-speed air turbine handpiece, there have been some reports over the past decade of cases caused by dental laser treatment. Emphysema as a complication caused by the air cooling spray of a dental laser is not well known, even though dental lasers utilize compressed air just as air turbines and syringes do. In this study, we comprehensively reviewed cases of emphysema attributed to dental laser treatment that appeared in the literature between January 2001 and September 2012, and we included three such cases referred to us. Among 13 cases identified in total, nine had cervicofacial subcutaneous and mediastinal emphysema. Compared with past reviews, the incidence of mediastinal emphysema caused by dental laser treatment was higher than emphysema caused by dental procedure without dental laser use. Eight patients underwent CO2 laser treatment and two underwent Er:YAG laser treatment. Nine patients had emphysema following laser irradiation for soft tissue incision. Dentists and oral surgeons should be cognizant of the potential risk for iatrogenic emphysema caused by the air cooling spray during dental laser treatment and ensure proper usage of lasers.

    DOI： 10.1111/adj.12119

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  • Vessel bifurcation localization based on intraoperative three-dimensional ultrasound and catheter path for image-guided catheter intervention of oral cancers Reviewed

    Kuan Luan, Takashi Ohya, Hongen Liao, Etsuko Kobayashi, Ichiro Sakuma

    Computerized Medical Imaging and Graphics   37 ( 2 )   113 - 122   2013.3

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    We present a method to localize intraoperative target vessel bifurcations under bones for ultrasound (US) image-guided catheter interventions. A catheter path is recorded to acquire skeletons for the target vessel bifurcations that cannot be imaged by intraoperative US. The catheter path is combined with the centerlines of the three-dimensional (3D) US image to construct a preliminary skeleton. Based on the preliminary skeleton, the orientations of target vessels are determined by registration with the preoperative image and the bifurcations were localized by computing the vessel length. An accurate intraoperative vessel skeleton is obtained for correcting the preoperative image to compensate for vessel deformation. A reality check of the proposed method was performed in a phantom experiment. Reasonable results were obtained. The in vivo experiment verified the clinical workflow of the proposed method in an in vivo environment. The accuracy of the centerline length of the vessel for localizing the target artery bifurcation was 2.4. mm. These results suggest that the proposed method can allow the catheter tip to stop at the target artery bifurcations and enter into the target arteries. This method can be applied for virtual reality-enhanced image-guided catheter intervention of oral cancers. © 2013 Elsevier Ltd.

    DOI： 10.1016/j.compmedimag.2013.01.007

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  • 口腔癌に対する動注法のための磁気式カテーテルナビゲーションシステムに関する研究 Reviewed

    Takashi Ohya

    Yokohama City University   2013.3

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  • Analysis of carotid artery deformation in different head and neck positions for maxillofacial catheter navigation in advanced oral cancer treatment Reviewed

    Takashi Ohya, Toshinori Iwai, Kuan Luan, Takashi Kato, Hongen Liao, Etsuko Kobayashi, Kenji Mitsudo, Nobukazu Fuwa, Ryuji Kohno, Ichiro Sakuma, Iwai Tohnai

    BIOMEDICAL ENGINEERING ONLINE   11   65   2012.9

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    Background: To improve the accuracy of catheter navigation, it is important to develop a method to predict shifts of carotid artery (CA) bifurcations caused by intraoperative deformation. An important factor affecting the accuracy of electromagnetic maxillofacial catheter navigation systems is CA deformations. We aimed to assess CA deformation in different head and neck positions.Methods: Using two sets of computed tomography angiography (CTA) images of six patients, displacements of the skull (maxillofacial segments), C1-C4 cervical vertebrae, mandible (mandibular segment), and CA along with its branches were analyzed. Segmented rigid bones around CA were considered the main causes of CA deformation. After superimposition of maxillofacial segments, C1-C4 and mandible segments were superimposed separately for displacement measurements. Five bifurcation points (vA-vE) were assessed after extracting the CA centerline. A new standardized coordinate system, regardless of patient-specific scanning positions, was employed. It was created using the principal axes of inertia of the maxillofacial bone segments of patients. Position and orientation parameters were transferred to this coordinate system. CA deformation in different head and neck positions was assessed.Results: Absolute shifts in the center of gravity in the bone models for different segments were C1, 1.02 +/- 0.9; C2, 2.18 +/- 1.81; C3, 4.25 +/- 3.85; C4, 5.90 +/- 5.14; and mandible, 1.75 +/- 2.76 mm. Shifts of CA bifurcations were vA, 5.52 +/- 4.12; vB, 4.02 +/- 3.27; vC, 4.39 +/- 2.42; vD, 4.48 +/- 1.88; and vE, 2.47 +/- 1.32. Displacements, position changes, and orientation changes of C1-C4 segments as well as the displacements of all CA bifurcation points were similar in individual patients.Conclusions: CA deformation was objectively proven as an important factor contributing to errors in maxillofacial navigation. Our study results suggest that small movements of the bones around CA can result in small CA deformations. Although patients' faces were not fixed properly during CT scanning, C1-C4 and vA-vE displacements were similar in individual patients. We proposed a novel method for accumulation of the displacement data, and this study indicated the importance of surrounding bone displacements in predicting CA bifurcation.

    DOI： 10.1186/1475-925X-11-65

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  • Experience of Tracheal Tube Fixation Through the Retromolar Space in Patients with Maxillofacial Fractures Reviewed

    IWAI TOSHINORI, MAEGAWA JIRO, YASUMURA KAZUNORI, YAJIMA YASUHARU, SHIBASAKI MAIKO, BABA JUNICHI, OHYA TAKASHI, OHHARA YOSHIHITO, TOHNAI IWAI

    日本口腔診断学会雑誌 = Japanese journal of oral diagnosis/oral medicine   25 ( 1 )   19 - 21   2012.2

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  • Study on an electromagnetic tracking system for catheter navigation

    Kanazawa Noboru, Sakuma Ichiro, Kobayashi Etsuko, Ohya Takashi, Kato Takashi, Fujimaki Ryo

    Proceedings of JSPE Semestrial Meeting   2012   373 - 374   2012

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    Language：Japanese   Publisher：The Japan Society for Precision Engineering  

    DOI： 10.11522/pscjspe.2012A.0.373.0

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  • Automatic and Robust Freehand Ultrasound Calibration Using a Tracked Pointer Reviewed

    LUAN Kuan, LIAO Hongen, OHYA Takashi, KOBAYASHI Etsuko, SAKUMA Ichiro

    Journal of Japan Society of Computer Aided Surgery   13 ( 4 )   437 - 443   2011.12

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    Freehand three-dimensional ultrasound system allows intra-operative imaging of pathologic tissue for image-guided surgical procedures. Accurate registration of ultrasound image for surgical navigation requires calibration that is time-consuming and tedious. We present a novel automatic and robust calibration method without a phantom. In the proposed method, a needle equipped with an electromagnetic tracking sensor is moved in the vicinity of an ultrasound imaging plane taken by a fixed ultrasound probe also equipped with an EM tracking sensor. The ultrasound images, tracker's and needle tip's physical coordinates are recorded simultaneously. For each ultrasound image, the needle tip is recognized and the image coordinates are identified automatically. A point registration between the needle tip image and physical coordinates is performed to estimate the calibration matrix. RANSAC is applied to minimize the registration error. Experiments are performed to verify the accuracy of the new calibration method. Results show that the needle tip can be accurately recognized in ultrasound images and the average fiducial registration error is 1.2 mm and hence applicable to the calibration for freehand ultrasound.

    DOI： 10.5759/jscas.13.437

    CiNii Books

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  • A Case of Navigation Aided Surgery for Facial Asymmetry after Treatment of Orbitozygomatic Fracture Reviewed

    IWAI TOSHINORI, MAEGAWA JIRO, YASUMURA KAZUNORI, OHHARA YOSHIHITO, OHYA TAKASHI, SHIBASAKI MAIKO, YAJIMA YASUHARU, MATSUI YOSHIRO, TOHNAI IWAI

    日本口腔診断学会雑誌 = Japanese journal of oral diagnosis/oral medicine   24 ( 3 )   407 - 412   2011.10

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  • A Case of Ultrasound-guided Intraoral Removal of Sialolithiasis in the Parotid Duct Reviewed

    YAMASHITA YOSUKE, IWAI TOSHINORI, MASUDA GENZABURO, YAJIMA YASUHARU, SHIBASAKI MAIKO, OHYA TAKASHI, OHHARA YOSHIHITO, AOKI NORIAKI, TOHNAI IWAI

    日本口腔診断学会雑誌 = Japanese journal of oral diagnosis/oral medicine   24 ( 3 )   384 - 388   2011.10

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  • Endoscopically-assisted Fixation with Biodegradable Plate for Condylar Base Fracture of the Mandible : A Case Report Reviewed

    IWAI TOSHINORI, MAEGAWA JIRO, YASUMURA KAZUNORI, OHHARA YOSHIHITO, SHIBASAKI MAIKO, OHYA TAKASHI, YAJIMA YASUHARU, MATSUI YOSHIRO, TOHNAI IWAI

    日本口腔診断学会雑誌 = Japanese journal of oral diagnosis/oral medicine   24 ( 3 )   402 - 406   2011.10

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  • 外頸動脈における血流動態の基礎的研究 流体解析を用いた血流シミュレーション

    大原 良仁, 岩井 俊憲, 矢島 康治, 大屋 貴志, 光藤 健司, 藤内 祝

    日本口腔外科学会雑誌   57 ( Suppl. )   189 - 189   2011.9

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  • Intravascular catheter navigation using path planning and virtual visual feedback for oral cancer treatment Reviewed

    Junchen Wang, Takashi Ohya, Hongen Liao, Ichiro Sakuma, Tianmiao Wang, Iwai Tohnai, Toshinori Iwai

    INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY   7 ( 2 )   214 - 224   2011.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

    Background It is tedious and difficult to position a flexible catheter in a target vessel branch within complicated-shaped vessels owing to the lack of real-time visual feedback. Digital subtraction angiography and fluoroscopic guidance are currently used for catheter placement.
    Methods The proposed method employs an electromagnetic (EM) tracking system to track a sensor-attached catheter. Vessel centerlines are extracted from the CT angiography image, based on which a navigational information tree is built to facilitate catheter manipulation. A virtual endoscopy technique is adopted to generate virtual intravascular video as visual feedback. Unscented Kalman filtering based image registration is performed to align the EM tracker frame with the anatomical atlas and to envision the target registration error.
    Results Preliminary experimental results showed the feasibility and effectiveness of the newmethod, with navigation accuracy of 1.80 +/- 0.85 mm.
    Conclusions The proposed method can provide continuous virtual visual feedback to facilitate catheter placement and has the potential for clinical use, with significant reduction in X-ray radiation exposure and doses of contrast agents. Copyright (C) 2011 John Wiley & Sons, Ltd.

    DOI： 10.1002/rcs.392

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  • A case of cancer of the oral floor (T4aN3M0) treated successfully with thermochemoradiotherapy Reviewed

    SHIBASAKI Maiko, MITSUDO Kenji, IWAI Toshinori, YAJIMA Yasuharu, OHYA Takashi, OHHARA Yoshihito, MITSUNAGA Sachiyo, HIROTA Makoto, TOHNAI Iwai

    Journal of Japanese Society of Oral Oncology   23 ( 1 )   9 - 15   2011.3

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    DOI： 10.5843/jsot.23.9

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  • A case with carcinoma of the upper gingiva and N3 treated successfully with retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia Reviewed

    MITSUNAGA Sachiyo, MITSUDO Kenji, IWAI Toshinori, YAJIMA Yasuharu, SHIBASAKI Maiko, OHYA Takashi, OHHARA Yoshihito, HIROTA Makoto, TOHNAI Iwai

    Journal of Japanese Society of Oral Oncology   22 ( 4 )   157 - 163   2010.12

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    DOI： 10.5843/jsot.22.157

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MISC

  • 舌癌動注化学放射線療法患者の体重減少率が術後栄養摂取へ及ぼす影響の検討

    陳 雪霏, 大屋 貴志, 小泉 敏行, 光藤 健司

    第40回日本栄養治療学会学術集会（JSPEN2025），神奈川   2025.2

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  • A Magnetic Tracking System Based on TMR Sensors with Novel Non-linearity Compensation for Catheter Navigation in Thin Blood Vessel

    Yukiya Minoura, Etsuko Kobayashi, Takashi Ohya, Ichiro Sakuma

    The 20th Asian Conference on Computer-Aided Surgery (ACCAS 2024), Korea   2024.9

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  • Analysis of carotid artery deformation due to catheter placement

    Takashi Ohya, Ichiro Sakuma, Wenran Cai, Yukiya Minoura, Etsuko Kobayashi, Toshinori Koizumi, Kenji Mitsudo

    CARS 2024 Computer Assisted Radiology and Surgery 36th International Congress and Exhibition, Spain 2024年6月   2024.6

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  • 舌癌に対する逆行性超選択的動注化学放射線療法に伴うカテーテル関連血流感染症に関する検討

    平野史也, 大屋貴志, 陳雪霏, 小栗千里, 小泉敏之, 來生 知, 光藤健司

    第216回日本口腔外科学会関東支部学術集会，東京   2023.12

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  • 進行口腔癌に対する動注化学放射線療法における胃瘻使用についての検討

    土山貴弘, 小泉敏之, 大屋貴志, 矢島康治, 南山周平, 平林大樹, 小栗千里, 岩井俊憲, 來生知, 光藤健司

    第216回日本口腔外科学会関東支部学術集会，東京   2023.12

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  • 超選択的動注化学療法のための TMR センサを用いた磁気トラッキングシステムにおけるセンサの非直交性の抑制 Reviewed

    箕浦有希也, 大屋貴志, 原 一晃, 小林英津子, 中川桂一, 佐久間一郎

    第32回日本コンピュータ外科学会大会，鹿児島   2023.12

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  • Design consideration of an electromagnetically tracked catheter with an integrated mechanical intravascular ultrasound imaging system and electromagnetic tracking sensors for endovascular catheter treatment navigation Reviewed

    Wenran Cai, Kazuaki Hara, Naoki Tomii, Etsuko Kobayashi, Takashi Ohya, Ichiro Sakuma

    CARS 2023 Computer Assisted Radiology and Surgery 35th International Congress and Exhibition, Germany   2023.6

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  • Diameters of lingual, facial, and maxillary arteries measured reproducibly on 3D-CT angiography images Reviewed

    Takashi Ohya, Ichiro Sakuma, Wenran Cai, Etsuko Kobayashi, Toshiyuki Koizumi, Kenji Mitsudo

    CARS 2023 Computer Assisted Radiology and Surgery 35th International Congress and Exhibition, Germany   2023.6

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  • TMRセンサを用いた磁気トラッキングシステムの高精度化に関する研究

    箕浦有希也, 大屋貴志, 原一晃, 小林英津子, 中川桂一, 佐久間一郎

    第32回 ライフサポート学会フロンティア講演会，東京（早稲田大学西早稲田キャンパス）   2023.3

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  • 歯科用エアータービンを用いて歯を切削する際に生じる高速飛沫

    大屋貴志, 光藤健司

    第35回日本口腔診断学会（3学会合同学術大会），札幌，ポスター発表   2022.9

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  • 舌癌に対する逆行性超選択的動注化学放射線療法の 治療効果と食事摂取状況の評価

    大屋 貴志, 陳 雪霏, 石川 聡一郎, 南山 周平, 矢島 康治, 小栗 千里, 小泉 敏之, 岩井 俊憲, 來生 知, 光藤 健司

    第56回日本口腔科学会関東地方部会，東京   2022.9

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  • 下顎に発生した歯牙硬組織の形成を伴うエナメル上皮線維腫の1例

    谷内健人, 大屋貴志, 富永拓也, 南山周平, 矢島康治, 北島大朗, 岩井俊憲, 小栗千里, 小泉敏之, 來生知, 光藤健司

    第213回日本口腔外科学会関東支部学術集会，東京   2022.5

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  • 歯科用エアータービンから排出する圧縮空気により生じる高速飛沫の可視化

    大屋貴志, 光藤健司

    第31回 日本有病者歯科医療学会学術大会，沖縄   2022.5

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  • 進行口底癌に対する逆行性超選択的動注化学放射線療法 Reviewed

    陳 雪霏, 大屋 貴志, 吉井 悠, 南山 周平, 矢島 康治, 馬場 隼一, 岩井 俊憲, 小栗 千里, 小泉 敏之, 來生 知, 光藤 健司

    2022.2

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  • 超選択的動注化学療法のためのTMRセンサを用いた磁気式カテーテルトラッキングシステムの評価

    永野里奈, 原 一晃, 中川桂一, 富井直輝, 小林英津子, 大屋貴志, 佐久間一郎

    第30回日本コンピュータ外科学会大会，茨城   2021.11

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  • Development of an electromagnetic catheter tracking system using TMR sensor for superselective intraarterial chemotherapy Reviewed

    R. Nagano, K. Hara, A. Ishijima, N. Tomii, K. Nakagawa, Y. Akagi, M. Yamazaki, H. Tsukihara, E. Kobayashi, T. Ohya, I. Sakuma

    CARS 2021 Computer Assisted Radiology and Surgery 35th International Congress and Exhibition   2021.6

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  • Data cleansing for development of an oral cancer diagnostic support system

    Akari Noda, Haruka Murakami, Takashi Ohya, Kenji Mitsudo, Yasuharu Yajima, Kazuto Hoshi

    2021.6

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  • 舌扁平上皮癌に対する逆行性超選択的動注化学放射線療法に関する検討

    大屋貴志, 陳 雪霏, 石川聡一郎, 林 雄一郎, 大橋伸英, 矢島康治, 馬場隼一, 岩井俊憲, 小栗千里, 小泉敏之, 來生 知, 光藤健司

    第45回日本頭頸部癌学会，千葉   2021.6

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  • Five-class Classification of Oral Images Using Deep Learning and Its Challenges

    2021.4

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  • 口腔癌検知に向けた自動化処理によるDataSet作成

    野田 明里, 村上 遥, 大屋 貴志, 矢島 康治, 光藤 健司, 星 和人

    第18回日本口腔ケア学会総会・学術大会，東京   15 ( 3 )   149 - 149   2021.4

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  • Deep Learningを用いた口腔衛生評価のため画像選別

    野田 明里, 村上 遥, 大屋 貴志, 矢島 康治, 光藤 健司, 星 和人

    第18回日本口腔ケア学会総会・学術大会，東京   15 ( 3 )   150 - 150   2021.4

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  • Automatic Pairing of Medical Information and Images That Are Not Linked to It

    The 1st Annual Meeting of the International Society of Oral Care, Tokyo   2021.4

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  • The distance between the bifurcations of the tumor feeding artery of oral cancer is unlikely to change with head and neck posture changes

    2020.6

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  • 局所進行下顎歯肉癌の下顎離断症例に対する下唇非切開による原発切除の検討

    小栗千里, 矢谷実英, 渡辺大智, 杉山聡美, 小杉泰史, 林雄一郎, 大橋伸英, 馬場隼一, 矢島康治, 大屋貴志, 飯田昌樹, 岩井俊憲, 小泉敏之, 來生知, 光藤健司

    日本口腔腫瘍学会総会・学術大会プログラム・抄録集   38th   2020

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  • Magnetic Field Measurement using TMR Sensor for Catheter Tracking

    永野里奈, 赤木友紀, 中川桂一, 山崎正俊, 月原弘之, 石島歩, 小林英津子, 佐久間一郎, 大屋貴志

    精密工学会大会学術講演会講演論文集   2020   2020

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  • 歯牙硬組織の形成を伴うエナメル上皮線維腫の 1 例

    富永拓也, 大屋貴志, 大橋伸英, 矢島康治, 本田康二, 飯田昌樹, 岩井俊憲, 小栗千里, 小泉敏之, 來生 知, 光藤健司

    第208回日本口腔外科学会関東支部学術集会，神奈川   2019.12

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  • 局所進行口底癌に対する逆行性超選択的動注化学放射線療法の治療効果

    陳 雪霏, 大屋貴志, 矢島康治, 大橋伸英, 飯田昌樹, 岩井俊憲, 小栗千里, 小泉敏之, 來生 知, 光藤健司

    第64回 日本口腔外科学会総会・学術大会   2019.10

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  • UICC第7/8版における舌扁平上皮癌への逆行性動注化学放射線療法の治療成績

    矢谷実英, 矢島康治, 飯田昌樹, 大屋貴志, 岩井俊憲, 小泉敏之, 小栗千里, 來生 知, 光藤健司

    第64回 日本口腔外科学会総会・学術大会   2019.10

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  • 8歳男児の左側上顎前歯部歯肉に発生したバーキットリンパ腫の1例

    仲盛優菜, 大橋伸英, 矢島康治, 大屋貴志, 飯田昌樹, 岩井俊憲, 小栗千里, 小泉敏之, 來生 知, 光藤健司

    第62回 日本口腔外科学会総会・学術大会   2019.10

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  • 頭頸部悪性唾液腺腫瘍に対する逆行性動注化学放射線療法の治療成績

    林 雄一郎, 大橋伸英, 矢島康治, 飯田昌樹, 大屋貴志, 岩井俊憲, 小泉敏之, 小栗千里, 來生 知, 光藤健司

    第64回 日本口腔外科学会総会・学術大会   2019.10

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  • Prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma treated by intra-arterial infusion chemotherapy concurrent with radiotherapy

    Yuichiro Hayashi, Kohei Osawa, Rina Nakakaji, Shuhei Minamiyama, Nobuhide Ohashi, Takashi Ohya, Masaki Iida, Toshinori Iwai, Tomomichi Ozawa, Senri Oguri, Toshiyuki Koizumi, Makoto Hirota, Mitomu Kioi, Masaharu Hata, Kenji Mitsudo

    Head and Neck   41   1777 - 1784   2019.6

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    © 2019 Wiley Periodicals, Inc. Background: The aim of this study was to evaluate the prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma (SCC) treated with intra-arterial infusion chemotherapy concurrent with radiotherapy. Methods: A total of 46 patients were reviewed retrospectively in this study. The treatment schedule comprised intra-arterial chemotherapy (total, 60 mg/m2 docetaxel and 150 mg/m2 cisplatin) and three-dimensional computed tomography based, daily conventional radiotherapy (total, 60 Gy/30 fr) for 6 weeks. Results: The median follow-up period was 40 months (range, 3-110 months). The 3-year overall survival and locoregional control rates for all patients were 64.3% and 84.3%, respectively. The OS rate of the patients with N0-1 was significantly higher than that of the patients with N ≥ 2 (P &lt;.05). No grade 5 toxicities were observed. Conclusions: Intra-arterial infusion chemotherapy concurrent with radiotherapy was effective for advanced maxillary gingival SCC.

    DOI： 10.1002/hed.25607

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  • 早期口腔癌N0症例に対する磁気法によるセンチネルリンパ節生検の検討

    杉山聡美, 岩井俊憲, 泉 敏治, 馬場隼一, 小栗千里, 飯田昌樹, 大屋貴志, 小泉敏之, 廣田 誠, 來生 知, 光藤健司

    第43回日本頭頸部癌学会，金沢   2019.6

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  • 下顎扁平上皮癌T4症例に対する逆行性超選択的動注化学放射線療法の検討

    小栗千里, 杉山聡美, 林 雄一郎, 大橋伸英, 馬場隼一, 大屋貴志, 飯田昌樹, 岩井俊憲, 小泉敏之, 來生 知, 光藤健司

    第43回日本頭頸部癌学会，金沢   2019.6

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  • 局所進行下顎歯肉扁平上皮癌T4症例に対する逆行性超選択的動注化学放射線療法の検討

    小栗千里, 杉山聡美, 林 雄一郎, 大橋伸英, 南山周平, 北島大朗, 柴崎麻衣子, 馬場隼一, 大屋貴志, 飯田昌樹, 岩井俊憲, 小泉敏之, 廣田 誠, 來生 知, 光藤健司

    第37回日本口腔腫瘍学会総会・学術大会，長崎   2019.1

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  • 局所進行口腔癌に対するcetuximab併用動注化学放射線療法の治療効果と安全性に関する前向き研究

    來生 知, 林 雄一郎, 大屋貴志, 飯田昌樹, 岩井俊憲, 小栗千里, 小泉敏之, 廣田 誠, 光藤健司

    第37回日本口腔腫瘍学会総会・学術大会，長崎   2019.1

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  • 早期口腔癌N0症例に対する磁気法による新しいセンチネルリンパ節生検の検討

    杉山聡美, 岩井俊憲, 泉 敏治, 馬場隼一, 小栗千里, 飯田昌樹, 大屋貴志, 小泉敏之, 廣田 誠, 來生 知, 光藤健司

    第37回日本口腔腫瘍学会総会・学術大会，長崎   2019.1

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  • 幻影細胞性歯原性癌に対し陽子線併用動注化学療法を施行し5年経過した1例

    大屋貴志, 髙山香名子, 林 雄一郎, 飯田昌樹, 岩井俊憲, 小栗千里, 小泉敏之, 廣田 誠, 來生 知, 光藤健司

    第37回日本口腔腫瘍学会総会・学術大会，長崎   2019.1

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  • N0舌癌に対する逆行性超選択的動注化学放射線療法：潜在性頸部リンパ節転移の制御

    南山周平, 林 雄一郎, 大屋貴志, 飯田昌樹, 岩井俊憲, 小栗千里, 小泉敏之, 廣田 誠, 光藤健司, 藤内 祝

    第63回日本口腔外科学会総会・学術大会   2018.11

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  • 局所進行口腔癌に対するcetuximab併用動注化学放射線療法の安全性と上乗せ効果

    來生 知, 林雄一郎, 大屋貴志, 飯田昌樹, 岩井俊憲, 小栗千里, 小泉敏之, 廣田 誠, 光藤健司, 藤内 祝

    第42回日本頭頸部癌学会   2018.6

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  • 進行舌癌に対する逆行性超選択的動注化学放射線療法の検討－副咽頭間隙再発の予防効果－

    小栗千里, 光藤健司, 林 雄一郎, 南山周平, 大橋伸英, 北島大朗, 馬場隼一, 大屋貴志, 飯田昌樹, 岩井俊憲, 小泉敏之, 廣田 誠, 來生 知, 藤内 祝

    第42回日本頭頸部癌学会   2018.6

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  • 舌癌術後補助化学療法中に発症した上腸間膜動脈症候群

    飯田昌樹, 大橋伸英, 林雄一郎, 南山周平, 大屋貴志, 岩井俊憲, 小栗千里, 小泉敏之, 廣田 誠, 來生 知, 光藤健司, 藤内 祝

    第36回日本口腔腫瘍学会総会・学術大会   2018.1

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  • 進行舌癌に対する逆行性超選択的動注化学放射線療法の検討－副咽頭間隙への効果－

    小栗千里, 光藤健司, 林 雄一郎, 南山周平, 大橋伸英, 北島大朗, 馬場隼一, 大屋貴志, 飯田昌樹, 岩井俊憲, 小泉敏之, 廣田 誠, 來生 知, 藤内 祝

    第36回日本口腔腫瘍学会総会・学術大会   2018.1

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  • 進行口腔癌に対する逆行性動注化学放射線療法の抗癌剤投与法による治療効果の検討：Weekly CDDP vs daily CDDP+weekly DOC

    林雄一郎, 光藤健司, 南山周平, 飯田昌樹, 大屋貴志, 小泉敏之, 岩井俊憲, 小栗千里, 廣田誠, 來生 知, 藤内 祝

    第36回日本口腔腫瘍学会総会・学術大会   2018.1

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  • T2-4N0舌癌に対する超選択的動注化学放射線療法：潜在性頸部リンパ節転移の制御

    南山周平, 光藤健司, 林 雄一郎, 大屋貴志, 飯田昌樹, 岩井俊憲, 小栗千里, 廣田 誠, 來生 知, 藤内 祝

    第36回日本口腔腫瘍学会総会・学術大会   2018.1

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  • 気管切開を伴う全身麻酔手術に併発した広範囲な皮下気腫の1例

    羽野和宏, 飯田昌樹, 大屋貴志, 岩井俊憲, 小栗千里, 小泉敏之, 廣田 誠, 來生 知, 光藤健司, 藤内 祝

    第206回日本口腔外科学会関東支部学術集会   2017.12

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  • 逆行性超選択的動注化学放射線療法のためのカメラを用いたマーカーレスナビゲーションシステムの精度評価

    栁田 健, 大屋貴志, 王 君臣, 岩井俊憲, 泉 敏治, 光藤健司, 小林英津子, 佐久間一郎, 藤内 祝

    第3回日本顎顔面再建先進デジタルテクノロジー学会総会・学術大会   2017.11

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  • 横浜市立大学附属病院歯科・口腔外科・矯正歯科における時間外救急外来受診患者の臨床統計的検討

    北畠健司, 大屋貴志, 飯田昌樹, 岩井俊憲, 小栗千里, 小泉敏之, 廣田 誠, 來生 知, 光藤健司, 藤内 祝

    第204回日本口腔外科学会関東支部学術集会   2017.10

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  • 口腔顎顔面外科手術におけるナビゲーション－下顎への適用－

    岩井俊憲, 小栗千里, 大屋貴志, 光藤健司, 藤内 祝

    第62回日本口腔外科学会総会・学術大会，ワークショップ「口腔外科領域におけるナビゲーション」   2017.10

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  • 逆行性超選択的動注化学放射線療法と両側頸部郭清術後の進行舌癌患者の嚥下動態解析

    大橋伸英, 岩井俊憲, 大屋貴志, 飯田昌樹, 小栗千里, 小泉敏之, 廣田 誠, 來生 知, 光藤健司, 藤内 祝

    第62回日本口腔外科学会総会・学術大会   2017.10

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  • 頸部郭清術中に認めた外頸静脈破格の1例

    杉山聡美, 岩井俊憲, 大屋貴志, 飯田昌樹, 小栗千里, 小泉敏之, 廣田 誠, 來生 知, 光藤健司, 藤内 祝

    第62回日本口腔外科学会総会・学術大会   2017.10

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  • 後期高齢口腔癌患者に対する逆行性超選択的動注化学放射線療法後の治療成績

    林 雄一郎, 光藤健司, 南山周平, 小泉敏之, 馬場隼一, 大屋貴志, 飯田昌樹, 岩井俊憲, 小泉敏之, 廣田 誠, 來生 知, 藤内 祝

    第41回日本頭頸部癌学会   2017.6

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  • 下顎歯肉癌T4の手術拒否症例に対する逆行性超選択的動注化学放射線療法

    小栗千里, 光藤健司, 大橋伸英, 馬場隼一, 大屋貴志, 飯田昌樹, 小泉敏之, 廣田 誠, 來生 知, 藤内 祝

    第41回日本頭頸部癌学会   2017.6

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  • 80歳以上口腔癌患者に対する逆行性動注化学放射線療法の治療成績の検討

    林 雄一郎, 光藤健司, 飯田昌樹, 小泉敏之, 吉井 悠, 大橋伸英, 飯坂友宏, 馬場隼一, 大屋貴志, 岩井俊憲, 小栗千里, 廣田 誠, 來生 知, 藤内 祝

    第35回日本口腔腫瘍学会総会・学術大会   2017.1

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  • 局所進行下顎歯肉癌に対する逆行性超選択的動注化学放射線療法

    小栗千里, 光藤健司, 大橋伸英, 飯坂友宏, 大久保牧子, 馬場隼一, 大屋貴志, 岩井俊憲, 岡本喜之, 小泉敏之, 廣田 誠, 來生 知, 藤内 祝

    第35回日本口腔腫瘍学会総会・学術大会   2017.1

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  • 光学式ナビゲーション手術で良好な顔貌の対称性が得られた上顎線維性骨異形成症の1例

    大屋貴志, 岩井俊憲, 中島英行, 光藤健司, 藤内 祝

    第61回日本口腔外科学会総会・学術大会   2016.11

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  • 超選択的動注法のための磁気式カテーテルナビゲーションシステムの開発

    松原 良太, 柳田 健, 王 君臣, 中川 桂一, 小林 英津子, 佐久間 一郎, 大屋 貴志, 藤内 祝

    日本コンピュータ外科学会誌   18 ( 4 )   282 - 282   2016.11

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  • 当科における転移性口腔癌の臨床的検討

    小杉泰史, 小栗千里, 大橋伸英, 高山香名子, 大屋貴志, 上田潤, 飯田昌樹, 岩井俊憲, 中島英行, 筑丸寛, 小泉敏之, 廣田誠, 來生知, 光藤健司, 藤内祝

    日本口腔腫瘍学会総会・学術大会プログラム・抄録集   34th   2016

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  • Clinical evaluation of thermochemoradiotherapy using retrograde superselective intra-arterial infusion for advanced oral cancer with cervical lymph node metastases Reviewed

    Iida M, Mitsudo K, Ohhara Y, Ohya T, Koizumi T, Nakashima H, Iwai T, Oguri S, Kioi M, Hirota M, Tohnai I

    AAOMS 96th Annual Meeting Scientific Sessions and Exhibition in Conjunction with the Japanese Society and Korean Association of Oral and Maxillofacial Surgeons, Honolulu, United States of America   2014.9

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  • Comparative Study between Centerline and Straight-Line Measurement of the External Carotid Artery Length Reviewed

    Ohya T, Iwai T, Kenji M, Kanazawa N, Kato T, Wang J, Kobayashi E, Ohta S, Sakuma I, Tohnai I

    AAOMS 96th Annual Meeting Scientific Sessions and Exhibition in Conjunction with the Japanese Society and Korean Association of Oral and Maxillofacial Surgeons, Honolulu, United States of America   2014.9

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  • 口腔癌に対する逆行性超選択的動注法のための磁気式カテーテルナビゲーションシステムの開発

    大屋 貴志, 王 君臣, 岩井 俊憲, 光藤 健司, 加藤 峰士, 金沢 昇, 廖 洪恩, 小林 英津子, 佐久間 一郎, 藤内 祝

    頭頸部癌   39 ( 2 )   267 - 267   2013.5

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  • Real-time visualized vessel and catheter path reconstruction for intravascular intervention Reviewed

    Kuan Luan, Hongen Liao, Takashi Ohya, Sanghyun Joung, Etsuko Kobayashi, Ichiro Sakuma

    IFMBE Proceedings   39   2142 - 2145   2013

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    Minimally invasive intravascular intervention is performed with the aid of catheters for therapy. We apply intra-operative freehand ultrasound and tracked catheter for guiding intravascular intervention. Current freehand 3D ultrasound techniques separate the scanning or acquisition step from the visualization step. This leads to no feedback during image acquisition. The reconstruction quality is highly dependent on scanning experience. A low-quality imaging even causes re-scanning and prolongs the time of image acquisition. In addition, the catheter path is important information implying the skeleton of the target vessel. It also helps doctor understand the catheter position relative to vessels for reducing the risk of vessel injuries. We developed a catheter navigation system that will allow real-time visualizing the scanned vessel volume as well as catheter path. The system consists of a freehand US for vessel reconstruction, an electromagnetic tracking system for locating the position and orientation of the ultrasound probe and catheter tip, a video frame grabber for capturing ultrasound frames, and a typical PC for performing real-time reconstruction and scene rendering. The system incorporates novel methods for visualizing data acquisition of image guided intravascular intervention in real time. This paper reports on current work in progress, and focuses on methods to achieving real-time visualizing reconstructions of freehand 3D ultrasound and catheter path. We demonstrate the system on a vessel phantom. The results suggest the system could visualize the reconstruction in real-time. © 2013 Springer-Verlag.

    DOI： 10.1007/978-3-642-29305-4_562

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  • Evaluation of standard variation of measurement error of Magnetic tracking system

    KATO T, OHYA T, KANAZAWA N, FUJIMAKI R, KOBAYASHI E, LIAO H, SAKUMA I

    Journal of Japan Society of Computer Aided Surgery : J.JSCAS   14 ( 3 )   236 - 237   2012.10

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  • Three-dimensional modelling procedure of the carotid artery and its surrounding bones by CT angiography images for assessment of the artery deformation Reviewed

    Ohya T, Iwai T, Fujimaki R, Kato T, Luan K, Liao H, Kobayashi E, Kohno R, Sakuma I, Tohnai I

    Computer Assisted Radiology and Surgery, Pisa, Italy   2012.6

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  • Flow Assessment in Artery Phantom using a Thin Fiberscope with Catheter for Detecting Carotid Artery Bifurcation During Retrograde Superselective Intra-arterial Catheterization for Oral Cancer Reviewed

    Ohya T, Kato T, Luan K, Liao H, Kobayashi E, Fujimaki R, Iwai T, Sakuma I, Tohnai I

    The World Congress on Medical Physics and Biomedical Engineering, Beijing, China   2012.5

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  • Evaluation using a probability distribution of measurement error of Magnetic tracking system

    KATO T, OHYA T, KOBAYASHI E, LIAO H, SAKUMA I, LUAN K

    Journal of Japan Society of Computer Aided Surgery : J.JSCAS   13 ( 3 )   284 - 285   2011.11

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  • Evaluation of the effective measurement space by analyzing the intensity distribution of the background magnetic field Reviewed

    Kato T, Ohya T, Luan K, Liao H, Kobayashi E, Sakuma I

    25th international congress and exhibition on Computer Assisted Radiology and Surgery, Berlin, Germany   2011.9

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  • High-quality Intraoperative Ultrasound Reconstruction Based on Catheter Path Reviewed

    Luan K, Ohya T, Liao H, Sakuma I

    The 7th Asian Conference on Computer Aided Surgery, Bangkok, Thailand   2011.8

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  • Rapid Calibration of 3D Freehand Ultrasound for Vessel Intervention Reviewed

    K. Luan, H. Liao, T. Ohya, J. Wang, I. Sakuma

    5TH KUALA LUMPUR INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING 2011 (BIOMED 2011)   35   716 - +   2011

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    To create a freehand three-dimensional (3D) ultrasound (US) system for image-guided vessel interventions, a US probe calibration must be performed to build 3D volumes from 2D vessel images. In this paper, a novel calibration method of 3D freehand US is described. It simply images the tip of a tracked needle that could freely move around within the coupling medium while the probe is fixed. The physical coordinates of the tip and the probe location are simultaneously recorded. Image coordinates of the tip are mapped to physical points. A RANSAC algorithm is applied to minimize the error matching image points and physical points. An accuracy evaluation experiment is performed to verify the proposed method. Results show that the needle tip can be accurately located and the RMS calibration error is 1.56mm. A phantom experiment and an in vivo experiment verify the availability of the technique in clinic. That means the present method is applicable to the calibration of a 3D freehand US in vessel interventions.

    DOI： 10.1007/978-3-642-21729-6_174

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  • A freehand on-line ultrasound probe calibration method based on unscented Kalman filtering

    WANG J., LUAN K., OHYA T., LIAO H., SAKUMA I.

    12 ( 3 )   274 - 275   2010.11

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  • US Probe Guidance Method Based EM Catheter Navigation

    OHYA T, WANG J, LIAO H, KOBAYASHI E, IWAI T, MITSUDO K, TOHNAI I, SAKUMA I

    Journal of Japan Society of Computer Aided Surgery : J.JSCAS   12 ( 3 )   432 - 433   2010.11

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  • Intraoperative 3D imaging for endoscopically-assisted reduction and fixation of subcondylar fractures

    Okubo M, Iwai T, Matsui Y, Maegawa J, Yajima Y, Ohya T, Ohhara Y, Hirota M, Mitsudo K, Tohnai I

    9th Asian Congress on Oral and Maxillofacial Surgery, Kuala Lumpur, Malaysia   2010.11

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  • 口腔癌に対するカテーテルナビゲーション応用を想定した異なる環境下における磁気式位置精度の検討

    大屋 貴志, 王 君臣, 廖 洪恩, 小林 英津子, 岩井 俊憲, 光藤 健司, 藤内 祝, 佐久間 一郎

    日本コンピュータ外科学会誌   12 ( 3 )   246 - 247   2010.11

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  • Endoscopic removal of pharyngeal packing gause swallowed during general anesthesia

    Iwai T, Matsui Y, Maegawa J, Yajima Y, Ohya T, Ohhara Y, Hirota M, Mitsudo K, Tohnai I

    9th Asian Congress on Oral and Maxillofacial Surgery, Kuala Lumpur, Malaysia   2010.11

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  • Endoscopically-assisted intraoral removal of lipoma in the buccal space

    Koyama C, Iwai T, Matsui Y, Maegawa J, Yajima Y, Ohya T, Ohhara Y, Hirota M, Mitsudo K, Tohnai I

    9th Asian Congress on Oral and Maxillofacial Surgery, Kuala Lumpur, Malaysia   2010.11

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  • Preoperative planning using CT angiography and computer assisted mandibular reconstruction with the fibula

    Fujino M, Iwai T, Matsui Y, Maegawa J, Yajima Y, Ohya T, Ohhara Y, Hirota M, Mitsudo K, Tohnai I

    9th Asian Congress on Oral and Maxillofacial Surgery, Kuala Lumpur, Malaysia   2010.11

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  • Endoscopically-assisted submandibular sialoadenectomy

    Iwai T, Matsui Y, Yajima Y, Ohya T, Ohhara Y, Chikumaru H, Hirota M, Mitsudo K, Tohnai I

    Congress of the European Association for Cranio-Maxillofacial Surgery, Bruges, Belgium   2010.9

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  • Image guided correction of mandibular asymmetry in patient with Garre's osteomyelitis under endoscopic and navigation guidance

    Iwai T, Yajima Y, Ohya T, Ohhara Y, Chikumaru H, Hirota M, Mitsudo K, Tohnai I

    Congress of the European Association for Cranio-Maxillofacial Surgery, Bruges, Belgium   2010.9

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  • Oral stings by spermatophores of squid

    Iwai T, Yajima Y, Ohya T, Ohhara Y, Mitsunaga S, Hirota M, Mitsudo K, Tohnai I

    Congress of the European Association for Cranio-Maxillofacial Surgery, Bruges, Belgium   2010.9

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  • Superselective intra-arterial infusion via the superficial temporal artery and occipital artery for gingival carcinoma of the mandible : simultaneous catheter placement to the maxillary artery and facial artery

    IWAI Toshinori, MITSUDO Kenji, FUKUI Takafumi, UEZONO Masayoshi, BABA Junichi, OYA Takashi, OHARA Yoshihito, SHOJI Shihomi, MITSUNAGA Sachiyo, ADACHI Makoto, WATANUKI Kei, CHIKUMARU Hiroshi, HIROTA Makoto, MATSUI Yoshiro, TOHNAI Iwai

    Toukeibu Gan   35 ( 3 )   273 - 278   2009.10

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    Language：Japanese  

    DOI： 10.5981/jjhnc.35.273

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Presentations

  • US Probe Guidance System Based EM Catheter Navigation

    大屋貴志, 廖 洪恩, 加藤峰士, 欒 寛, 王 君臣, 小林 英津子, 岩井俊憲, 光藤健司, 藤内 祝, 佐久間 一郎

    第４回システム疾患生命科学による先端医療技術開発シンポジウム  2011.3 

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  • Three-dimensional error distribution of electromagnetic tracking catheter navigation for retrograde superselective intra-arterial infusion

    大屋貴志, 岩井俊憲, 光藤健司, 藤内 祝

    医療ICTシンポジウム，神奈川  2011.3 

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  • 磁気式カテーテルナビゲーションにおける情報統合・画像処理・表示

    大屋貴志, 廖 洪恩, 王 君臣, 加藤峰士, 欒 寛, 小林英津子, 岩井俊憲, 光藤健司, 藤内 祝, 佐久間一郎

    第50回日本生体医工学会，オーガナイズドセッション「医用画像処理・表示」，東京  2011.4 

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  • 口腔顎顔面外科手術におけるナビゲーション－下顎への適用－

    岩井俊憲, 小栗千里, 大屋貴志, 光藤健司, 藤内 祝

    第62回日本口腔外科学会総会・学術大会，ワークショップ「口腔外科領域におけるナビゲーション」  2017.10 

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Research Projects

  • 院内で発生する飛沫・エアロゾルの可視化と最適な気流制御法（代表）

    2022.10 - 2024.3

    令和4年度学長裁量事業（学術的研究推進事業） YCU未来共創プロジェクト 

    大屋貴志, 加藤英明, 荒井康裕, 出井真史, 後藤温

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    Authorship：Principal investigator 

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  • 超小型磁気センサー内蔵のカテーテルナビゲーションシステムに関する研究（代表）

    2020.4 - 2025.3

    日本学術振興会 科学研究費助成事業 基盤研究(B) 

    大屋貴志

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    Authorship：Principal investigator 

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  • 大量CT画像のベクトル量子化と機械学習による顎顔面領域術後の顔貌変形推定モデル（代表）

    2019.8 - 2020.3

    学長裁量事業 学術的研究推進事業 若手科研費支援プロジェクト 

    大屋貴志

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    Authorship：Principal investigator 

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  • Accuracy evaluation of magnetic catheter navigation system for oral cancer

    Grant number：16K16411  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Ohya Takashi

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    Authorship：Principal investigator 

    Grant amount：\3770000 （ Direct Cost: \2900000 、 Indirect Cost：\870000 ）

    Catheter placement for retrograde superselective intra-arterial chemoradiotherapy must safely and reliably insert a catheter into the target artery so that the anticancer agent can directly flow into advanced oral cancer. Therefore, we are developing a three-dimensional catheter navigation system that can track the tip of a catheter. In this study, the patient's face was taken with a video camera, and the accuracy evaluation of the system that correctly displayed the CT image of the artery on the video image was performed on patient’s models. This system recognizes the shape of upper teeth and automatically superimposes images. It was found that the error was about 1 mm in registration based on the front teeth and molars.

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  • Development of innovative minimally invasive treatment using novel delivery drug system for oral cancer

    Grant number：16H05544  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Tohnai Iwai

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    Grant amount：\16900000 （ Direct Cost: \13000000 、 Indirect Cost：\3900000 ）

    We simulated distribution of anticancer drug in tumor feeding artery to treat effectively intra-arterial chemotherapy for oral cancer. This study showed catheter placement into each tumor feeding artery for instable distribution of anticancer drug in common trunk. We developed new registration method in catheter navigation, and this study showed maxillary anterior teeth registration provides sufficient accuracy.

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  • Development of novel endoscope for superselective intra-arterial infusion for advanced oral cancer

    Grant number：15K15745  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    TOHNAI Iwai

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    Grant amount：\3510000 （ Direct Cost: \2700000 、 Indirect Cost：\810000 ）

    The purpose of this study is to develop a novel endoscope for superselective intra-arterial infusion for oral cancer. This endoscope could connect to 3CCD imaging system(FT-203F, FiberTech), and had irrigation and working channels. But, the imaging quality was not sufficient in phantom experiment. Therefore, we will improve this quality od the endoscope.

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  • 口腔癌に対する逆行性超選択的動注法のためのelectromagnetic tracking navigation systemの開発（分担）

    2009 - 2012

    グローバルCOEプログラム 

    藤内 祝

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    Grant type：Competitive

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Other

  • 「研究データの質向上の指導者育成研修事業」の講習会修了（AMED）

    2021.6

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    国立研究開発法人日本医療研究開発機構（AMED）
    株式会社 三菱総合研究所 ヘルスケア＆ウェルネス本部 ヘルスケアイノベーショングループ による実施 （令和3年6月26日）．
    修了証（03 医研開第5695号）

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  • 第1回 3Dプリンター活用技術検定試験合格

    2017.2

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    一般社団法人コンピュータ教育振興協会主催
    3Dプリンター活用技術基礎
    実施日 2017年2月12日
    認定日 2017年3月28日

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Teaching Experience

  • 口腔外科学（口腔外科学総論）

    Institution：横浜市立大学

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