Updated on 2025/11/13

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写真a

 
Kosuke Imura
 
Organization
Graduate School of Medicine Department of Medicine Department of Neuroanatomy Lecturer
School of Medicine Medical Course
Title
Lecturer
Homepage
http://www-user.yokohama-cu.ac.jp/~neuroana/
Profile

神経解剖学・比較神経学的なアプローチで神経系の研究に取り組んでおります。
これまで、視床枕における長投射性インターニューロンの解析や下側頭葉への投射、魚類の小脳回路などを調べてまいりました。現在は、魚類の咽頭顎骨の神経支配と破骨細胞の関係を形態学的に調べております(Imura et al., 2024)。また手の筋肉の形態と機能についても興味を持っております。

External link

Degree

  • 博士（医学） ( 日本医科大学 )

Research Interests

  • 比較神経学

  • 骨代謝

  • 魚類

  • 視床枕

  • 小脳

  • 咽頭顎

  • 破骨細胞

  • 神経解剖学

Research Areas

  • Life Science / Anatomy and histopathology of nervous system

Education

  • Nippon Medical School   Graduate School

    - 2003.3

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  • Kitasato University

    - 1999.3

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  • Kitasato University

    - 1997.3

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Research History

  • 横浜市立大学医学部   神経解剖学   講師

    2014.4

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  • The Nippon Dental University   School of Life Dentistry at Tokyo   Lecturer

    2012.4 - 2014.3

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  • The Nippon Dental University   School of Life Dentistry at Tokyo   Assistant Professor

    2006.4 - 2012.3

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  • 理化学研究所 脳科学総合研究センター   脳皮質機能構造研究チーム 研究員

    2003.4 - 2006.3

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Professional Memberships

Papers

  • Vagal afferent projections from the pharyngeal jaw of the cichlid Nile tilapia (<i>Oreochromis niloticus</i>) Reviewed

    Kosuke Imura, Akihito Takeda, Masato Endo, Masanori Nasu, Kengo Funakoshi

    European Journal of Histochemistry   69 ( 4 )   2025.9

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    Authorship：Lead author,　Corresponding author  

    DOI： 10.4081/ejh.2025.4248

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  • Innervation and osteoclast distribution in the inferior pharyngeal jaw of the cichlid Nile tilapia (<i>Oreochromis niloticus</i>) Reviewed

    Kosuke Imura, Akihito Takeda, Masato Endo, Kengo Funakoshi

    The Anatomical Record   307 ( 6 )   2139 - 2148   2024.1

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    In addition to an oral jaw, cichlids have a pharyngeal jaw, which is used for crushing and processing captured prey. The teeth and morphology of the pharyngeal jaw bones adapt to changes in prey in response to changes in the growing environment. This study aimed to explore the possible involvement of the peripheral nervous system in remodeling the cichlid pharyngeal jaw by examining the innervation of the inferior pharyngeal jaw in the Nile tilapia, Oreochromis niloticus. Vagal innervation was identified in the Nile tilapia inferior pharyngeal jaw. Double staining with tartrate‐resistant acid phosphatase and immunostaining with the neuronal markers, protein gene product 9.5, and acetylated tubulin, revealed that osteoclasts, which play an important role in remodeling, were distributed in the vicinity of the nerves and were in apposition with the nerve terminals. This contact between peripheral nerves and osteoclasts suggests that the peripheral nervous system may play a role in remodeling the inferior pharyngeal jaw in cichlids.

    DOI： 10.1002/ar.25381

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  • Postnatal development of thalamic reticular nucleus projections to the anterior thalamic nuclei in rats Reviewed International journal

    Hitoshi Fujita, Kosuke Imura, Masahito Takiguchi, Kengo Funakoshi

    European Journal of Histochemistry   66 ( 2 )   2022.3

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    The thalamic reticular nucleus (TRN) projects inhibitory signals to the thalamus, thereby controlling thalamocortical connections. Few studies have examined the development of TRN projections to the anterior thalamic nuclei with regard to axon course and the axon terminal distributions. In the present study, we used parvalbumin (PV) immunostaining to investigate inhibitory projections from the TRN to the thalamus in postnatal (P) 2- to 5-week-old rats (P14-35). The distribution of PV-positive (+) nerve fibers and nerve terminals markedly differed among the anterior thalamic nuclei at P14. Small, beaded nerve terminals were more distributed throughout the anterodorsal nucleus (AD) than in the anteroventral nucleus (AV) and anteromedial nucleus (AM). PV+ fibers traveling from the TRN to the AD were observed in the AV and AM. Nodular nerve terminals, spindle or en passant terminals, were identified on the axons passing through the AV and AM. At P21, axon bundles traveling without nodular terminals were observed, and nerve terminals were distributed throughout the AV and AM similar to the AD. At P28 and P35, the nerve terminals were evenly distributed throughout each nucleus. In addition, DiI tracer injections into the retrosplenial cortex revealed retrogradely-labeled projection neurons in the 3 nuclei at P14. At P14, the AD received abundant projections from the TRN and then projected to the retrosplenial cortex. The AV and AM seem to receive projections with distinct nodular nerve terminals from the TRN and project to the retrosplenial cortex. The projections from TRN to the AV and AM with nodular nerve terminals at P14 are probably developmental-period specific. In comparison, the TRN projections to the AD at P14 might be related to the development of spatial navigation as part of the head orientation system.

    DOI： 10.4081/ejh.2022.3370

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  • Fiber Connections of the Caudal Corpus Cerebelli, with Special Reference to the Intrinsic Circuitry, in a Teleost (<i>Oreochromis niloticus</i>) Reviewed

    Kosuke Imura, Naoyuki Yamamoto, Masami Yoshimoto, Masato Endo, Kengo Funakoshi, Hironobu Ito

    BRAIN BEHAVIOR AND EVOLUTION   89 ( 1 )   15 - 32   2017

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000455962

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  • Distributions of calcitonin gene-related peptide and substance P in the human maxillary sinus of Japanese cadavers Reviewed

    Iwao Sato, Kosuke Imura, Yoko Miwa, Shunji Yoshida, Masataka Sunohara

    JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY   40 ( 8 )   E249 - E252   2012.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jcms.2011.10.027

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  • Topographical organization of TRPV1-immunoreactive epithelium and CGRP-immunoreactive nerve terminals in rodent tongue Reviewed

    Masato Kawashima, Kosuke Imura, Iwao Sato

    EUROPEAN JOURNAL OF HISTOCHEMISTRY   56 ( 2 )   129 - 134   2012

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4081/ejh.2012.e21

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  • A morphological study of the blood vessels associated with periodontal probing depth in human gingival tissue Reviewed

    Shunji Yoshida, Kenzou Noguchi, Kosuke Imura, Yoko Miwa, Masataka Sunohara, Iwao Sato

    Okajimas Folia Anatomica Japonica   88 ( 3 )   103 - 109   2011.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2535/ofaj.88.103

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  • Evaluation of the blood and nerve supply patterns in the molar region of the maxillary sinus in Japanese cadavers Reviewed

    Shunji Yoshida, Taisuke Kawai, Rieko Asaumi, Yoko Miwa, Kosuke Imura, Hirohisa Koseki, Masataka Sunohara, Takashi Yosue, Iwao Sato

    Okajimas Folia Anat Jpn   87 ( 3 )   129 - 133   2010.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    The maxillary sinus (MS) in the maxilla bone is located near the orbit, the nasal cavity and the oral cavity; however, the positioning of the constituent bones is complex. The posterior superior alveolar branches of the maxillary artery and nerve are distributed in the lateral wall of the MS. The courses of these blood vessels and nerves are restricted by the morphology of the craniofacial bones, and the landmarks used in dental implant treatment of these courses mainly run along the lateral wall of the MS. In this study, 19 human cadavers with 34 sides of Japanese origin (ranging in age from 59-94 years, mean 77.7 +/- 9.8 years) were prepared for measurement of the MS, the superior alveolar artery and the infraorbital artery using cone beam computed tomography (CBCT). The posterior superior alveolar artery (PSAA) of the lateral wall of the MS can be classified into one of three groups based on the supply pattern. In the greatest number of cadavers, the PSAA ran mainly to the lateral surface of the zone between the superior border of the alveolar foramen and the inferior border of the MS (53.0%, 18/34). In others, the PSAA ran to the zone between the infraorbital foramen and the superior border of the alveolar foramen (17.6%, 6/34); in a third group, the PSAA ran to the zone between the inferior border of the MS and the greater palatine foramen (23.5%, 8/34). The lest of two sides are spread out in this area (5.9%, 2/34). CBCT is the most accurate tool to evaluate important anatomical parameters, such as the distance of the blood supply, for the implant of grafts in the floor of the MS during surgical procedures.

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  • Understanding the formation of maxillary sinus in Japanese human foetuses using cone beam CT Reviewed

    Rieko Asaumi, Iwao Sato, Yoko Miwa, Kosuke Imura, Masataka Sunohara, Taisuke Kawai, Takashi Yosue

    Surgical and Radiologic Anatomy   32 ( 8 )   745 - 751   2010.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00276-010-0678-5

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  • Observing the bony canal structure of the human maxillary sinus in Japanese cadavers using cone beam CT Reviewed

    Iwao Sato, Taisuke Kawai, Shunji Yoshida, Yoko Miwa, Kosuke Imura, Rieko Asaumi, Masataka Sunohara, Takashi Yosue

    Okajimas Folia Anatomica Japonica   87 ( 3 )   123 - 128   2010

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2535/ofaj.87.123

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  • Identification of the novel localization of tenascinX in the monkey choroid plexus and comparison with the mouse Reviewed

    Kosuke Imura, Iwao Sato

    EUROPEAN JOURNAL OF HISTOCHEMISTRY   53 ( 4 )   225 - 231   2009.10

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

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  • Classifications of tunnel-like structure of human petrotympanic fissure by cone beam CT Reviewed International journal

    Iwao Sato, Hiroshi Arai, Rieko Asaumi, Kosuke Imura, Taisuke Kawai, Takashi Yosue

    Surgical and Radiologic Anatomy   30 ( 4 )   323 - 326   2008.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    The discomallear ligament (DML) runs through a narrow space of bony petrotympanic fissure, which joins the articular disc of the temporomandibular joint (TMJ) and the malleus in the tympanic cavity. Previous report suggest that an anatomical feature gives rise to TMJ pain and dysfunction. Recently, the movement of the malleus caused by hypertension on the discomallear ligament is important to the function of the TMJ. The purpose of this study is to define its morphological features using the cone beam CT (CBCT) and anatomical dissection of Japanese cadavers. Petrotympanic fissure and DML were observed in 14 cadavers (eight males and six females). It is revealed that a wide tunnel-like structure was found on CBCT images in the middle region of the petrotympanic fissure to the malleus in the tympanic cavity consisting of mainly three types: a wide tunnel-shaped structure (29.2%, 7/24, type 1), a tunnel-shaped structure widely open in the entrance of the petrotympanic fissure to the mandibular fossa and gradually thinning out in the tympanic cavity (20.8%, 5/24, type 2), and a tunnel-shaped structure widely open in the entrance of the mandibular fossa, middle region with flat-shaped tunnel structure and narrow exit in the tympanic cavity (41.7%, 10/24, type 3). These structures between the entrance of the petrotympanic fissure and the exit at the tympanic cavity are important to define the limited movement of the malleus. Therefore, morphological feature of the ligaments in malleus may relate to TMJ pain, dysfunction and hearing function.

    DOI： 10.1007/s00276-008-0327-4

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    Other Link： http://link.springer.com/article/10.1007/s00276-008-0327-4/fulltext.html

  • Novel localization of tenascin-X in adult mouse leptomeninges and choroid plexus Reviewed

    Kosuke Imura, Iwao Sato

    ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER   190 ( 4 )   324 - 328   2008

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.aanat.2008.04.003

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  • Distribution of LYVE-1 and CD31 in postnatal rat masseter muscle Reviewed

    Iwao Sato, Kosuke Imura, Yoko Miwa, Mami Miyado, Masataka Sunohara

    ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER   190 ( 4 )   329 - 338   2008

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.aanat.2008.03.013

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  • Distribution of slow muscle fiber of muscle spindle in postnatal rat masseter muscle Reviewed

    Iwao Sato, Kosuke Imura, Yoko Miwa, Yoshiaki Ide, Megumi Murata, Masataka Sunohara

    Okajimas Folia Anatomica Japonica   84 ( 3 )   99 - 106   2007.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2535/ofaj.84.99

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  • Giant neurons in the macaque pulvinar: a distinct relay subpopulation Reviewed

    Kosuke Imura, Kathleen S. Rockland

    FRONTIERS IN NEUROANATOMY   1   2   2007.11

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/neuro.05/002.2007

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  • Long-range interneurons within the medial pulvinar nucleus of macaque monkeys Reviewed

    Kosuke Imura, Kathleen S. Rockland

    JOURNAL OF COMPARATIVE NEUROLOGY   498 ( 5 )   649 - 666   2006.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/cne.21085

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  • Fiber connections of the lateral valvular nucleus in a percomorph teleost, tilapia (<i>Oreochromis niloticus</i>) Reviewed

    CY Yang, M Yoshimoto, HG Xue, N Yamamoto, K Imura, N Sawai, Y Ishikawa, H Ito

    JOURNAL OF COMPARATIVE NEUROLOGY   474 ( 2 )   209 - 226   2004.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/cne.20150

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  • Afferent connections of the corpus cerebelli in holocentrid teleosts Reviewed

    HG Xue, N Yamamoto, CY Yang, K Imura, H Ito

    BRAIN BEHAVIOR AND EVOLUTION   64 ( 4 )   242 - 258   2004

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000080244

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  • Fiber connections of the torus longitudinalis and optic tectum in holocentrid teleosts Reviewed

    HG Xue, N Yamamoto, CY Yang, G Kerem, M Yoshimoto, K Imura, H Ito

    JOURNAL OF COMPARATIVE NEUROLOGY   462 ( 2 )   194 - 212   2003.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/cne.10730

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  • Fiber connections of the torus longitudinalis in a teleost: Cyprinus carpio re-examined Reviewed

    H Ito, N Yamamoto, M Yoshimoto, N Sawai, CY Yang, HG Xue, K Imura

    JOURNAL OF COMPARATIVE NEUROLOGY   457 ( 2 )   202 - 211   2003.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/cne.10560

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  • Topographical organization of an indirect telencephalo-cerebellar pathway through the nucleus paracommissuralis in a teleost, <i>Oreochromis niloticus</i> Reviewed

    K Imura, N Yamamoto, N Sawai, M Yoshimoto, CY Yang, HG Xue, H Ito

    BRAIN BEHAVIOR AND EVOLUTION   61 ( 2 )   70 - 90   2003

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000069353

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MISC

  • 無脊椎動物と脊椎動物におけるGABAニューロンの局在とはたらき Invited Reviewed

    船越 健悟, 井村, 幸介

    脳神経内科   90 ( 4 )   344 - 351   2019.4

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  • 中枢神経投射路の交叉：系統発生の立場から Invited Reviewed

    船越 健悟, 井村, 幸介

    神経内科   84 ( 3 )   331 - 338   2016.4

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Awards

  • 横浜市立大学医学部 ベストティーチャー賞（個人賞1位）

    2025.5  

    井村幸介

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  • 横浜市立大学医学部 ベストティーチャー賞（団体賞3位）

    2020.5  

    神経解剖学教室

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  • 北里大学同窓会 若手研究者研究奨励賞

    2010.5  

    井村 幸介

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Research Projects

  • 破骨細胞はなぜ神経束に密着するのか：シクリッド咽頭顎骨リモデリング時の解析

    2024 - 2026

    日本学術振興会 学術研究助成基金助成金、基盤研究（C） 

    井村幸介

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    Authorship：Principal investigator 

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  • 魚類をモデルとした骨代謝に関わる中枢神経内ネットワークの解析

    2020 - 2021

    横浜市立大学  学長裁量事業 学術的研究推進事業 

    井村幸介

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    Authorship：Principal investigator 

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  • シクリッド咽頭顎の骨代謝に関わる脳内領域間ネットワークの解析

    2019 - 2020

    横浜市立大学  学長裁量事業 学術的研究推進事業 

    井村幸介

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    Authorship：Principal investigator 

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  • シクリッド咽頭顎骨の神経‐骨代謝クロストークに関わる神経回路の解析

    2016 - 2018

    日本学術振興会 学術研究助成基金助成金、基盤研究（C） 

    井村 幸介

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    Authorship：Principal investigator  Grant type：Competitive

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  • 骨の代謝‒免疫機能に関わる頭頚部神経支配の解析

    2012 - 2013

    日本学術振興会 学術研究助成基金助成金、若手研究（B） 

    井村 幸介

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    Authorship：Principal investigator  Grant type：Competitive

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  • 顎顔面領域の骨代謝機能に関わるグルタミン酸作動性三叉神経回路の解析

    2009 - 2010

    文部科学省 科学研究費補助金、若手研究（B） 

    井村 幸介

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    Authorship：Principal investigator  Grant type：Competitive

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  • 骨代謝機能に関わるグルタミン酸を分泌する顎関節の三叉神経終末の解析

    2007 - 2008

    文部科学省 科学研究費補助金、若手研究（B） 

    井村 幸介

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    Authorship：Principal investigator  Grant type：Competitive

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Other

  • 死体解剖資格認定（厚生労働省；系統解剖学・第10366号）

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