Updated on 2025/11/10
Study of epigenome dynamics during germline and embryonic development.
Epigenetic regulation of stem cell differentiation.
PhD ( The Graduate University for Advanced Studies )
Histology
Epigenetics
Germ cells
Stem cells
Molecular biology
Anatomy
Informatics / Life, health and medical informatics / Bioinformatics
Life Science / Anatomy
Life Science / Genetics
Life Science / Developmental biology
Yokohama City University Histology and Cell Biology, School of Medicine Lecturer/Assistant Professor
2019.4
Yokohama City University Histology and Cell Biology, School of Medicine Assistant Professor
2013.3 - 2019.3
The Babraham Institute Epigenetics Programme
2009.4 - 2013.2
National Institute of Genetics Division of Human Genetics
2006.4 - 2009.3
Japan Society of Histochemistry and Cytochemistry
2023.8
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
THE GENETICS SOCIETY OF JAPAN
The Japanese Society for Epigenetics
Abnormal H3K27me3 underlies degenerative spermatogonial stem cells in cryptorchid testis Reviewed International journal
Kazushige Kuroha*, Ivana Dočkal*, Uroš Radović, Kuniko Nakajima, Ikue Hoshi, Shion Matsuda, Noriko Kojitani, Kazuyuki Ohbo, Shin-ichi Tomizawa
Development 152 ( 2 ) dev.204239 2025.1
A behind-the-scenes role of BDNF in the survival and differentiation of spermatogonia Reviewed International journal
Shin-ichi Tomizawa*, Kazushige Kuroha*, Michio Ono, Kuniko Nakajima, Kazuyuki Ohbo
Asian Journal of Andrology 27 ( 1 ) 37 - 43 2025.1
Spatial and temporal expression analysis of BMP signal modifiers, Smoc1 and Smoc2, from postnatal to adult developmental stages in the mouse testis. Reviewed
Michio Ono, Kuniko Nakajima, Shin-ichi Tomizawa, Takayuki Shirakawa, Ippei Okada, Hirotomo Saitsu, Naomichi Matsumoto, Kazuyuki Ohbo
Gene Expression Patterns 119383 2024.11
Shin-ichi Tomizawa, Rachel Fellows, Michio Ono, Kazushige Kuroha, Ivana Dočkal, Yuki Kobayashi, Keisuke Minamizawa, Koji Natsume, Kuniko Nakajima, Ikue Hoshi, Shion Matsuda, Masahide Seki, Yutaka Suzuki, Kazushi Aoto, Hirotomo Saitsu, Kazuyuki Ohbo
Development 151 ( 18 ) dev202834 2024.9
Oxygen concentration affects de novo DNA methylation and transcription in in vitro cultured oocytes Reviewed
Florence Naillat, Heba Saadeh, Joanna Nowacka-Woszuk, Lenka Gahurova, Fatima Santos, Shin-ichi Tomizawa, Gavin Kelsey
Clinical Epigenetics 13 132 2021.6
Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing Reviewed International journal
Yuki Takada, Ruken Yaman-Deveci, Takayuki Shirakawa, Jafar Sharif, Shin-ichi Tomizawa, Fumihito Miura, Takashi Ito, Michio Ono, Kuniko Nakajima, Yoko Koseki, Fuyuko Shiotani, Kei-ichiro Ishiguro, Kazuyuki Ohbo, Haruhiko Koseki
Development 148 ( 10 ) dev194605 2021.5
<i>Tsga8</i> is required for spermatid morphogenesis and male fertility in mice. Reviewed International journal
Yuki Kobayashi*, Shin-ichi Tomizawa*, Michio Ono, Kazushige Kuroha, Keisuke Minamizawa, Koji Natsume, Selma Dizdarević, Ivana Dočkal, Hiromitsu Tanaka, Tatsukata Kawagoe, Masahide Seki, Yutaka Suzuki, Narumi Ogonuki, Kimiko Inoue, Shogo Matoba, Konstantinos Anastassiadis, Nobuhisa Mizuki, Atsuo Ogura, Kazuyuki Ohbo *co-first
Development 148 ( 8 ) dev196212 2021.4
Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities. Reviewed International journal
Noriko Miyake, Hidehisa Takahashi, Kazuyuki Nakamura, Bertrand Isidor, Yoko Hiraki, Eriko Koshimizu, Masaaki Shiina, Kazunori Sasaki, Hidefumi Suzuki, Ryota Abe, Yayoi Kimura, Tomoko Akiyama, Shin-ichi Tomizawa, Tomonori Hirose, Kohei Hamanaka, Satoko Miyatake, Satomi Mitsuhashi, Takeshi Mizuguchi, Atsushi Takata, Kazuyuki Obo, Mitsuhiro Kato, Kazuhiro Ogata, Naomichi Matsumoto
American Journal of Human Genetics 106 ( 1 ) 13 - 25 2020.1
Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice. Reviewed International journal
Kuniko Nakajima, Michio Ono, Uroš Radović, Selma Dizdarević, Shin-ichi Tomizawa, Kazushige Kuroha, Go Nagamatsu, Ikue Hoshi, Risa Matsunaga, Takayuki Shirakawa, Takeyuki Kurosawa, Yasunari Miyazaki, Masahide Seki, Yutaka Suzuki, Haruhiko Koseki, Masataka Nakamura, Toshio Suda, Kazuyuki Ohbo
Disease Models & Mechanisms 12 ( 11 ) 2019.11
Kmt2b conveys monovalent and bivalent H3K4me3 in mouse spermatogonial stem cells at germline and embryonic promoters. Reviewed International journal
Shin-ichi Tomizawa, Yuki Kobayashi, Takayuki Shirakawa, Kumiko Watanabe, Keita Mizoguchi, Ikue Hoshi, Kuniko Nakajima, Jun Nakabayashi, Sukhdeep Singh, Andreas Dahl, Dimitra Alexopoulou, Masahide Seki, Yutaka Suzuki, Hélène Royo, Antoine H F M Peters, Konstantinos Anastassiadis, A Francis Stewar, Kazuyuki Ohbo
Development 145 ( 23 ) dev169102 2018.11
Transcription and chromatin determinants of de novo DNA methylation timing in oocytes Reviewed
Lenka Gahurova*, Shin-ichi Tomizawa*, Sebastien A. Smallwood, Kathleen R. Stewart-Morgan, Heba Saadeh, Jeesun Kim, Simon R. Andrews, Taiping Chen, Gavin Kelsey *co-first
Epigenetics & Chromatin 10 25 2017.5
Dynamic changes in histone modifications precede de novo DNA methylation in oocytes Reviewed
Kathleen R. Stewart, Lenka Veselovska, Jeesun Kim, Jiahao Huang, Heba Saadeh, Shin-ichi Tomizawa, Sebastien A. Smallwood, Taiping Chen, Gavin Kelsey
Genes & Development 29 ( 23 ) 2449 - 2462 2015.12
Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape Reviewed
Lenka Veselovska, Sebastien A. Smallwood, Heba Saadeh, Kathleen R. Stewart, Felix Krueger, Stéphanie Maupetit Méhouas, Philippe Arnaud, Shin-ichi Tomizawa, Simon Andrews, Gavin Kelsey
Genome Biology 16 ( 1 ) 209 2015.9
DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis Reviewed
Naoki Kubo, Hidehiro Toh, Kenjiro Shirane, Takayuki Shirakawa, Hisato Kobayashi, Tetsuya Sato, Hidetoshi Sone, Yasuyuki Sato, Shin-ichi Tomizawa, Yoshinori Tsurusaki, Hiroki Shibata, Hirotomo Saitsu, Yutaka Suzuki, Naomichi Matsumoto, Mikita Suyama, Tomohiro Kono, Kazuyuki Ohbo, Hiroyuki Sasaki
BMC Genomics 16 ( 1 ) 624 2015.8
Epigenetic regulation in stem cell development, cell fate conversion, and reprogramming Reviewed
Kazuyuki Ohbo, Shin-ichi Tomizawa
Biomolecular Concepts 6 ( 1 ) 1 - 9 2015.3
Shin-ichi Tomizawa, Takayuki Shirakawa, Kazuyuki Ohbo
Current Pathobiology Reports 2 ( 1 ) 1 - 9 2014.3
An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity Reviewed
Takayuki Shirakawa, Ruken Yaman-Deveci, Shin-ichi Tomizawa, Yoshito Kamizato, Kuniko Nakajima, Hidetoshi Sone, Yasuyuki Sato, Jafar Sharif, Akio Yamashita, Yuki Takada-Horisawa, Shosei Yoshida, Kiyoe Ura, Masahiro Muto, Haruhiko Koseki, Toshio Suda, Kazuyuki Ohbo
Development 140 ( 17 ) 3565 - 3576 2013.9
A distinct reprogramming strategy in zebrafish compared to mammals Invited
Shin-ichi Tomizawa
Experimental Medicine 31 ( 14 ) 2242 - 2243 2013.9
Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice Reviewed
Takuya Takahashi, Hitomi Matsuzaki, Shin-ichi Tomizawa, Eiichi Okamura, Tomoko Ichiyanagi, Akiyoshi Fukamizu, Hiroyuki Sasaki, Keiji Tanimoto
Gene 508 ( 1 ) 26 - 34 2012.10
Genomic imprinting and its relevance to congenital disease, infertility, molar pregnancy and induced pluripotent stem cell Reviewed
Shin-ichi Tomizawa, Hiroyuki Sasaki
Journal of Human Genetics 57 ( 2 ) 84 - 91 2012.2
DNA methylation establishment during oocyte growth: mechanisms and significance Reviewed
Shin-ichi Tomizawa, Joanna Nowacka-Woszuk, Gavin Kelsey
International Journal of Developmental Biology 56 ( 10-12 ) 867 - 875 2012
Dynamic CpG island methylation landscape in oocytes and preimplantation embryos Reviewed
Sebastien A. Smallwood, Shin-ichi Tomizawa, Felix Krueger, Nico Ruf, Natasha Carli, Anne Segonds-Pichon, Shun Sato, Kenichiro Hata, Simon R. Andrews, Gavin Kelsey
Nature Genetics 43 ( 8 ) 811 - U126 2011.8
Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Reviewed International journal
Toshiaki Watanabe, Shin-ichi Tomizawa, Kohzoh Mitsuya, Yasushi Totoki, Yasuhiro Yamamoto, Satomi Kuramochi-Miyagawa, Naoko Iida, Yuko Hoki, Patrick J Murphy, Atsushi Toyoda, Kengo Gotoh, Hitoshi Hiura, Takahiro Arima, Asao Fujiyama, Takashi Sado, Tatsuhiro Shibata, Toru Nakano, Haifan Lin, Kenji Ichiyanagi, Paul D Soloway, Hiroyuki Sasaki
Science 332 ( 6031 ) 848 - 52 2011.5
Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes Reviewed
Shin-ichi Tomizawa, Hisato Kobayashi, Toshiaki Watanabe, Simon Andrews, Kenichiro Hata, Gavin Kelsey, Hiroyuki Sasaki
Development 138 ( 5 ) 811 - 820 2011.3
Epigenetics of the cell Invited
Shin-ichi Tomizawa, Hiroyuki Sasaki
Gene & Medicine 上 145 - 148 2008.4
Story of epigenetics Invited
Hiroyuki Sasaki, Shin-ichi Tomizawa
Farumashia 43 ( 4 ) 310 - 314 2007.4
精子幹細胞分化を制御するエピジェネティックな機構の解析
大保和之, 南澤恵佑, 尾野道男, 中島久仁子, FELLOWS Rachel, 富澤信一
日本解剖学会総会・全国学術集会抄録集 129th 2024
Role of a novel protease inhibitor for spermatogenesis and immune homeostasis
富澤信一, FELLOWS Rachel, 尾野道男, 黒羽一誠, DOCKAL Ivana, 南澤恵佑, 鈴木穣, 才津浩智, 大保和之
日本解剖学会総会・全国学術集会抄録集 128th 2023
Cryptorchidism induces abnormal epigenetic and transcriptional signatures in spermatogonia
尾野道男, DOCKAL Ivana, RADOVIC Uros, 大保和之, 富澤信一
日本解剖学会総会・全国学術集会抄録集 128th 2023
WFDCファミリーに属するプロテアーゼインヒビターWFDC2の発現及び機能解析
林亜葵, 中島久仁子, 尾野道男, 富澤信一, 大保和之
日本解剖学会総会・全国学術集会抄録集 127th 2022
Regulation of male germ cell development through KMT2B-dependent epigenetic programming
富澤信一, 小林裕貴, FELLOWS Rachel, 尾野道男, 黒羽一誠, 田中宏光, 河越龍方, 才津浩智, 鈴木穣, 水木信久, 小倉淳郎, 大保和之
日本解剖学会総会・全国学術集会抄録集 127th 2022
精子幹細胞分化系列におけるエピジェネティックおよびトランスクリプトームの解析
富澤信一, 小林裕貴, PETERS Antoine H.F.M., ANASTASSIADIS Konstantinos, STEWART A Francis, 関真秀, 鈴木穣, CLARK Stephen, KELSEY Gavin, 大保和之
日本分子生物学会年会プログラム・要旨集 42nd 2019
エピジェネティックなエンハンサーマーカーからみた精子幹細胞
大保和之, 富澤信一
日本遺伝学会大会プログラム・予稿集 91st 2019
エピジェネティックな機構を介した精子発生制御メカニズムの解析
小林裕貴, 尾野道男, 溝口敬太, 夏目幸治, 富澤信一, 河越龍方, 水木信久, 小倉淳郎, 大保和之
日本解剖学会総会・全国学術集会講演プログラム・抄録集 124th 2019
Kmt2b(H3K4メチル化酵素)遺伝子欠損マウスにおける精細管の微細形態
尾野道男, 小林裕貴, 富澤信一, 大保和之
日本解剖学会総会・全国学術集会講演プログラム・抄録集 123rd 2018
腎臓において,過剰動脈および回転異常を呈した一例
荻窪まどか, 長谷川広大, 後藤希実, 張田佳代, 松沼まり, 氏赳人, 羽鳥尚寛, 富澤信一, 尾野道男, 鳥本いづみ, 吉田敬一郎, 宮木孝昌, 大保和之
日本解剖学会総会・全国学術集会講演プログラム・抄録集 121st 2016
尾部欠損及び鈎状突起の低形成と三葉化を示した1例
川村飛翔, 渡辺武俊, 藤本優, 加藤伸忠, 大庭千佳, 祖父江瑤子, 氏赳人, 羽鳥尚寛, 富澤信一, 尾野道男, 鳥本いづみ, 吉田敬一郎, 宮木孝昌, 大保和之
日本解剖学会総会・全国学術集会講演プログラム・抄録集 121st 2016
新生仔マウスの精原幹細胞の形成と分化における全ゲノムDNAメチル化およびトランスクリプトーム解析
久保 直樹, 藤 英博, 白根 健次郎, 白川 峰征, 小林 久人, 佐藤 哲也, 曾根 秀利, 佐藤 康人, 富澤 信一, 鶴崎 美徳, 柴田 弘紀, 才津 浩智, 鈴木 穣, 松本 直通, 須山 幹太, 河野 友宏, 大保 和之, 佐々木 裕之
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 88回・38回 [1P0606] - [1P0606] 2015.12
核内微細形態変化とエピジェネティックな変化の精巣幹細胞分化における役割
富澤信一, 白川峰征, 大保和之
日本解剖学会総会・全国学術集会講演プログラム・抄録集 119th 2014
マウス新生仔期の精原幹細胞の分化におけるメチローム変動
久保直樹, 藤英博, 白根健次郎, 白根健次郎, 白川峰征, 神里亮人, 曾根秀利, 佐藤康人, 鶴崎美徳, 富澤信一, 柴田弘紀, 才津浩智, 松本直通, 大保和之, 佐々木裕之, 佐々木裕之
日本分子生物学会年会プログラム・要旨集 36th 2013
Comprehensive methylome analysis to the identification of new imprinted genes
Natasha Carli, Felix Krueger, Sebastien A. Smallwood, Shin-Ichi Tomizawa, Luisa Vigevani, Anne Segonds-Pichon, Wendy Dean, Simon R. Andrews, Gavin Kelsey
GENETICS RESEARCH 94 ( 6 ) 354 - 355 2012.12
マウス卵子におけるnon-CpGメチル化機構の解析
白根健次郎, 千葉初音, 富澤信一, 秦健一郎, 佐々木裕之
日本分子生物学会年会プログラム・要旨集 34th 2011
piRNAによるインプリント遺伝子Rasgrf1のDNAメチル化制御
渡部聡朗, 三ツ矢幸造, 宮川さとみ, 中馬新一郎, 富澤信一, 十時泰, 豊田敦, 山本耕裕, 保木裕子, 佐渡敬, 野瀬俊明, 仲野徹, 佐々木裕之
日本RNA学会年会要旨集 11th 50 2009.7
マウス生殖細胞におけるインプリント領域のDNAメチル化解析
富澤信一, 富澤信一, 小林久人, 渡部聡朗, 渡部聡朗, 堀池浩子, 佐々木裕之, 佐々木裕之
生化学 2008
PCB分解菌Alcaligenes denitrificans A41株に存在するgenomic island(GI)の水平伝達
今村俊規, 富澤信一, 前田理久
日本農芸化学会関東支部講演要旨集 2007 ( Nov ) 2007
Hall of Fame, Best Teacher Award
2024.5 Yokohama City University School of Medicine
Best Teacher Award 2022
2023.5 Yokohama City University School of Medicine
Best Teacher Award 2021
2022.5 Yokohama City University School of Medicine
Best Teacher Award 2020
2021.5 Yokohama City University School of Medicine
Translational regulation of spermatogonial stem cell differentiation and subpopulation maintenance
Grant number：25K12619 2025.4 - 2028.3
JSPS KAKENHI Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Kazushige Kuroha, Shinichi Tomizawa
Authorship：Coinvestigator(s)
Epicode for germ cell priming
Grant number：24A306 2025.4 - 2027.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A)
Shinichi Tomizawa
Authorship：Principal investigator
DNA methylation establishment in human male germ cells
Grant number：24KK0143 2024.9 - 2028.3
JSPS KAKENHI JSPS KAKENHI Grant-in-Aid for Fund for the Promotion of Joint International Research
Toshiaki Watanabe, Shinichi Tomizawa, Musashi Kubiura-Ichimaru
Authorship：Coinvestigator(s)
Grant amount：\20930000 （ Direct Cost: \16100000 、 Indirect Cost：\4830000 ）
Differentiation of stem cell subpopulation for spermatogenesis
2023.4 - 2026.3
JSPS KAKENHI Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Shinichi Tomizawa
Authorship：Principal investigator
Molecular basis of infertility associated with epigenome abnormality
Grant number：22H04925 2022.4
JSPS KAKENHI JSPS KAKENHI Grant Number JP22H04925 (PAGS)
Authorship：Principal investigator
Molecular basis of infertility associated with epigenome abnormality
Grant number：16H06279 2021.4
JSPS KAKENHI 16H06279
Shinichi Tomizawa
Authorship：Principal investigator
Molecular basis of infertility associated with epigenome abnormality
Grant number：20K09543 2020.4 - 2023.3
JSPS KAKENHI Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Shinichi Tomizawa
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
Analysis of epigenome infertility mechanisms by the state-of-art single cell and ultra low-input histone modification analysis methods
Grant number：19KK0183 2019.10 - 2023.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)) Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Kazuyuki Ohbo, Shinichi Tomizawa, Ayako Suzuki
Grant amount：\18460000 （ Direct Cost: \14200000 、 Indirect Cost：\4260000 ）
Identification and dynamic analysis of true stem cells in testicular stem cells using the latest single cell analysis method
Grant number：19K07250 2019.4 - 2022.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
Kazuyuki Ohbo, Shinichi Tomizawa, Michio Ono
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
Male infertility associated with epigenetic mechanisms
2019
The Naito Foundation Research Grant
Shinichi Tomizawa
Authorship：Principal investigator Grant type：Competitive
Quality control for correct spermatogenesis and post-fertilization development
2019
The Takeda Science Foundation Mecical Research Grant
Shinichi Tomizawa
Authorship：Principal investigator Grant type：Competitive
Identification of genes required for spermatogonial stem cell differentiation
Grant number：17K15549 2017.4 - 2019.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)
Shinichi Tomizawa
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
In this study, we performed genome-wide transcriptome and epigenome analyses to understand the proliferation and differentiation mechanisms of spermatogonial stem cells (SSCs) in mammals. We collected mouse SSCs and progenitor spermatonia from mouse testis and analysed mRNA and DNA methylation status at the single cell level (M&T-seq). We found that SSCs are potentially heterogeneous with subpopulations showing different transcription and methylation status. Furthermore, from histological and histone modification analyses, we found that a histone methyltransferase Kmt2b plays an essential role for SSC differentiation.
Role of chromocenter formation in cellular differentiation
Grant number：16K15174 2016.4 - 2017.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research Grant-in-Aid for Challenging Exploratory Research
Shinichi Tomizawa
Authorship：Principal investigator Grant type：Competitive
Grant amount：\3640000 （ Direct Cost: \2800000 、 Indirect Cost：\840000 ）
Spermatogonial stem cells support a lifelong process of spermatogenesis. Epigenetic factors and higher-order nuclear architecture are implicated to regulate changes in expression of a number of genes important for spermatogonial stem cell differentiation. During this process, it is reported that apparent chromocenter formation as well as a series of epigenetic changes occur. This study aimed to establish a method to investigate the role of chromocenter formation in the differentiation step. However, the chromocenter isolation protocol based on a published literature did not appear to work for a small number of cells, and further optimization was considered necessary.
Study of a protein complex for tissue stem cell proliferation and maintenance
2014.4 - 2017.3
MEXT Creation of Innnovation Center for Advanced Interdisciplinary Research Areas Program
Shinichi Tomizawa
Authorship：Principal investigator Grant type：Competitive
The role of nuclear structure and an epigenetic switch in spermatogonial stem cell differentiation
Grant number：26860137 2014.4 - 2017.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)
Shinichi Tomizawa
Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）
It is well established that long-term spermatogenesis in mammals is supported by spermatogonial stem cells (SSCs). However, the molecular mechanisms governing SSC maintenance and differentiation is poorly understood. This study focused on dynamic changes in nuclear structure and epigenetic status that occur during SSC differentiation. These changes are important for gene expression programs and hence may greatly contribute to the conversion of cellular characteristics as SSCs differentiate. To identify the epigenetic changes in more detail, SSCs and progenitor cells were sorted and the global epigenetic status of each cell population was analyzed.
Analysis of small RNAs for testicular stem cell differentiation
2013 - 2014
Yokohama Foundation for Advancement of Medical Science Grant for Promoted Research
Shinichi Tomizawa
Authorship：Principal investigator Grant type：Competitive
Structure and Function of the Human Body I
2025.4 Institution：Kanagawa Eisei Gakuen College
Anatomy and Physiology
2020.7 Institution：School of Science, Yokohama City University
Mechanism of the Human Body
2020.4 - 2024.3 Institution：Yokohama Central Hospital Affiliated Nursing School
Histology
2013.4 Institution：Graduate School of Medicine, Yokohama City University
Histology
2013.4 Institution：School of Medicine, Yokohama City University
Anatomy and Development
2013.4 Institution：School of Medicine, Yokohama City University
Micromorphology
2013.4 Institution：Graduate School of Medicine, Yokohama City University
