Updated on 2025/08/28

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写真a

 
Masanari Umemura
 
Organization
Graduate School of Medicine Department of Medicine Cardiovascular Research Associate Professor
School of Medicine Medical Course
Title
Associate Professor
Other name(s)
Umemura M
Profile

大学病院や市中病院で循環器医として勤務した後、米国留学を経て、現職。生理学教員として基礎研究や、医学部生・大学院生への教育を行っている。

日本内科学会 総合内科専門医、日本循環器学会 専門医、日本医学教育学会 認定医学教育専門家、日本生理学会 卓越生理学エデュケーター

日本心臓病学会 心臓病上級臨床医 (Fellow of the Japanese College of Cardiology: FJCC会員)及び代議員、

YCU Strategic Research Leader

External link

Degree

  • 博士(医学) ( 2006.3   横浜市立大学 )

Research Interests

  • Calcium Signaling

  • Mitochondria

  • Human Cardiac Fibroblasts

  • Heart Failure

  • Oncocardiology

  • Development of medical device

Research Areas

  • Life Science / Cardiology

  • Life Science / Pharmacology

  • Life Science / Applied molecular and cellular biology

  • Life Science / Medical systems

  • Life Science / Physiology

Education

  • Yokohama City University   Graduate

    2003.4 - 2007.3

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Research History

  • Yokohama City University   School of Medicine Medical Course   Associate Professor

    2022.4

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    Country:Japan

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  • Yokohama City University Graduate School of Medicine   YCU Strategic Research Leader

    2024.8 - 2026.3

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Professional Memberships

  • 日本メディカルAI学会

    2024.1

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  • 日本バイオインフォマティクス学会

    2022

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  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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  • JAPANESE SOCIETY OF PATHOPHYSIOLOGY

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  • American Heart Association

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  • THE JAPANESE CIRCULATION SOCIETY

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  • THE JAPANESE PHARMACOLOGICAL SOCIETY

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  • PHYSIOLOGICAL SOCIETY OF JAPAN

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  • Japanese College of Cardiology

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  • American Physiological Society

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  • THE JAPAN SOCIETY FOR MEDICAL EDUCATION

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Committee Memberships

  • 日本心臓病学会   代議員  

    2024.11   

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    Committee type:Academic society

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  •   Editorial board section member  

    2023.4   

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    Committee type:Other

    https://www.mdpi.com/journal/jcdd/editors?search=Umemura

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  • 日本病態生理学会   評議員  

    2019   

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    Committee type:Academic society

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  • 日本薬理学会   学術評議員  

    2017   

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    Committee type:Academic society

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  • 日本生理学会   評議員  

    2016.3   

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Papers

  • Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming Reviewed

    Akimoto T, Islam Md R, Nagasako A, Kishi K, Nakakaji R, Ohtake M, Hasumi H, Yamaguchi T, Yamada S, Yamamoto T, Ishikawa Y, Umemura M

    Cancer Science   2024.6

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Cancer Science - 2024 - Akimoto - Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming.pdf

    DOI: 10.1111/cas.16243

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  • EP4-Induced Mitochondrial Localization and Cell Migration Mediated by CALML6 in Human Oral Squamous Cell Carcinoma Reviewed

    Ishikawa S, Umemura M, Nakakaji R, Nagasako A, Nagao K, Mizuno Y, Sugiura K, Kioi M, Mitsudo K, Ishikawa Y

    Communications Biology   7 ( 1 )   2024.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma.pdf

    DOI: 10.1038/s42003-024-06231-4.

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  • Physiological Functions of Calcium Signaling via Orai1 in Various Cancers Invited Reviewed

    Umemura M, Nakakaji R, Ishikawa Y

    The Journal of Physiological Sciences (100周年記念号)   73 ( 21 )   2023.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Physiological functions of calcium signaling via Orai1 in cancer.pdf

    DOI: 10.1186/s12576-023-00878-0

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  • Reactive Fibrosis Precedes Doxorubicin-induced Heart Failure through Sterile Inflammation Reviewed International journal

    Tanaka R, Umemura M, Narikawa M, Hikichi M, Osawa K, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y

    ESC Heart Failure   7 ( 2 )   588 - 603   2019.12

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  • Prostaglandin E2 receptor EP4 regulates cell migration via Orai1 Reviewed International journal

    Kohei Osawa, Masanari Umemura, Rina Nakakaji, Ryo Tanaka, Rafikul Md Islam, Akane Nagasako, Takayuki Fujita, Utako Yokoyama, Toshiyuki Koizumi, Kenji Mitsudo, Yoshihiro Ishikawa

    Cancer Science   111 ( 1 )   160 - 174   2019.11

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    The EP4 prostanoid receptors are one of four receptor subtypes for prostaglandin E2 (PGE2 ). Therefore, EP4 may play an important role in cancer progression. However, little information is available regarding their function per se, including migration and the cellular signaling pathway of EP4 in oral cancer. First, we found that mRNA and protein expression of EP4 was abundantly expressed in human-derived tongue squamous cell carcinoma cell lines HSC-3 and OSC-19. The EP4 agonist (ONO-AE1-437) significantly promoted cell migration in HSC-3 cells. In contrast, knockdown of EP4 reduced cell migration. Furthermore, we confirmed that knockdown of EP4 suppressed metastasis of oral cancer cells in the lungs of mice in vivo. Therefore, we focused on the mechanism of migration/metastasis in EP4 signaling. Interestingly, EP4 agonist significantly induced intracellular Ca2+ elevation not in only oral cancer cells but also in other cells, including normal cells. Furthermore, we found that EP4 activated PI3K and induced Ca2+ influx through Orai1 without activation of store depletion and stromal interaction molecule 1 (STIM1). Immunoprecipitation showed that EP4 formed complexes with Orai1 and TRPC1, but not with STIM. Moreover, the EP4 agonist ONO-AE1-437 phosphorylated ERK and activated MMP-2 and MMP-9. Knockdown of Orai1 negated EP4 agonist-induced ERK phosphorylation. Taken together, our data suggested that EP4 activated PI3K and then induced Ca2+ influx from the extracellular space through Orai1, resulting in ERK phosphorylation and promoting cell migration. Migration is regulated by EP4/PI3K/Orai1 signaling in oral cancer.

    File: Osawa_et_al-2020-Cancer_Science.pdf

    DOI: 10.1111/cas.14247

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  • Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways Reviewed International journal

    Narikawa M, Umemura M, Tanaka R, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y

    PLOS ONE   2 ( 14(9) )   e0221940   2019.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Although doxorubicin (DOX)-induced cardiomyopathy causes lethal heart failure (HF), no early detection or effective treatment methods are available. The principal mechanisms of cardiotoxicity are considered to involve oxidative stress and apoptosis of cardiomyocytes. However, the effect of DOX on cardiac fibroblasts at non-lethal concentrations remains unknown. The aim of this study was to investigate the direct effect of doxorubicin on the activation of cardiac fibroblasts independent of cell death pathways. We first found that DOX induced α-SMA expression (marker of trans-differentiation) at a low concentration range, which did not inhibit cell viability. DOX also increased MMP1, IL-6, TGF-β and collagen expression in human cardiac fibroblasts (HCFs). In addition, DOX promoted Akt and Smad phosphorylation. A Smad inhibitor prevented DOX-induced α-SMA and IL-6 protein expression. An PI3K inhibitor also prevented MMP1 mRNA expression in HCFs. These findings suggest that DOX directly induces fibrotic changes in HCFs via cell death-independent pathways. Furthermore, we confirmed that these responses are organ- and species-specific for HCFs based on experiments using different types of human and murine fibroblast cell lines. These results suggest potentially new mechanisms of DOX-induced cardiotoxicity from the viewpoint of fibrotic changes in cardiac fibroblasts.

    File: Narikawa et al. Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways.pdf

    DOI: 10.1371/journal.pone.0221940

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  • A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging Reviewed

    Haruki Eguchi, Masanari Umemura, Reiko Kurotani, Hidenobu Fukumura, Itaru Sato, Jeong-Hwan Kim, Yujiro Hoshino, Jin Lee, Naoyuki Amemiya, Motohiko Sato, Kunio Hirata, David J. Singh, Takatsugu Masuda, Masahiro Yamamoto, Tsutomu Urano, Keiichiro Yoshida, Katsumi Tanigaki, Masaki Yamamoto, Mamoru Sato, Seiichi Inoue, Ichio Aoki, Yoshihiro Ishikawa

    SCIENTIFIC REPORTS   5 ( 9194 )   2015.3

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    File: EI236.pdf

    DOI: 10.1038/srep09194

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  • Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration

    Masanari Umemura, Erdene Baljinnyam, Stefan Feske, Mariana S. De Lorenzo, Lai-Hua Xie, Xianfeng Feng, Kayoko Oda, Ayako Makino, Takayuki Fujita, Utako Yokoyama, Mizuka Iwatsubo, Suzie Chen, James S. Goydos, Yoshihiro Ishikawa, Kousaku Iwatsubo

    PLOS ONE   9 ( 2 )   2014.2

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    File: Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma.pdf

    DOI: 10.1371/journal.pone.0089292

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  • Transcriptional diversity and expression of NEDD4L gene in distal nephron Reviewed

    M Umemura, T Ishigami, K Tamura, M Sakai, Y Miyagi, K Nagahama, Aoki, I, K Uchino, A Rohrwasser, JM Lalouel, S Umemura

    Biochemical and Biophysical Research Communications   339 ( 4 )   1129 - 1137   2006.1

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    File: Transcriptional diversity and expression of NEDD4L gene in distal nephron..pdf

    DOI: 10.1016/j.bbrc.2005.11.120

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  • Translationally controlled tumor protein interacts with connexin 43 and facilitates intercellular coupling between cardiomyocytes

    Yaopeng Hu, Wenqian Cai, Yuko Hidaka, Keizo Hiraishi, Jiehui Cang, Masanari Umemura, Utako Yokoyama, Björn C. Knollmann, Yoshihiro Ishikawa, Takayuki Fujita

    Frontiers in Cell and Developmental Biology   13   2025.3

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    Introduction

    Connexins are gap junction proteins that play pivotal roles in intercellular communication. Connexin 43 (Cx43) is one of the most ubiquitously expressed connexin isoforms in human. Cx43 has been demonstrated to be involved in the pathological process of various diseases, including arrhythmias. Recently, translationally controlled tumor protein (TCTP), a highly conserved anti-apoptotic protein, has been shown to play an important role in protecting against the development of heart failure. However, its role in arrhythmogenesis remains unclear. In this study, we aimed to examine the interaction between TCTP and Cx43 and investigate the roles of TCTP in the formation of Cx43 gap junction channels and gap junctional intercellular communication (GJIC) in cardiomyocytes.

    Methods and results

    We found that TCTP was predominantly expressed in the intercalated discs of mouse heart tissue. Cx43 in adult mouse hearts was coimmunoprecipitated using a TCTP-specific antibody. Additionally, co-localization of TCTP and Cx43 was demonstrated using a proximity ligation assay in iPS cell-derived human cardiomyocytes. TCTP silencing reduced the formation of Cx43 gap junction channels at the intercellular contacts between cardiomyocytes. Moreover, TCTP silencing significantly attenuated GJIC among cardiomyocytes. Interestingly, the development of ventricular arrhythmia was attenuated in cardiomyocyte-specific TCTP-overexpressing mice.

    Conclusion

    These findings indicate that TCTP regulates GJIC. Thus, TCTP may be a therapeutic target for preventing Cx43-related pathogenesis.

    DOI: 10.3389/fcell.2025.1549063

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  • Analysis of Nocturia Determinants Using a Novel Portable Urine‐Measuring Device

    Kotaro Yamasue, Tomohiko Kaneoka, Tomoyuki Tatenuma, Masanari Umemura

    Neurourology and Urodynamics   44 ( 4 )   722 - 727   2025.1

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    ABSTRACT

    Aims

    To investigate the relationship between nocturia and values measured using a novel multifunctional portable urine‐measuring device.

    Methods

    Thirty‐five older men with nocturia and/or high‐normal or high blood pressure were enrolled to record measurements on one full day (24 h) and two nights using the portable device during urination. Participants used a semi‐conical cup with a small hole equipped with a conductivity sensor, temperature sensor, and timer to measure urine volume, salt content, urine temperature, and urination speed.

    Results

    Two participants were excluded owing to oliguria. The mean age of 33 participants was 75.2 ± 7.4 years (range: 55–85 years). The mean nocturnal urination frequency, including the first urination after waking, was 2.1 ± 0.6 times. Simple correlation analysis revealed that nocturnal urine frequency significantly increased with nocturnal urine volume (r = 0.65, p < 0.001) and salt content (r = 0.57, p < 0.001) but not with 24‐h urine volume and salt content. Furthermore, the frequency significantly decreased with nocturnal urine temperature (r = −0.37, p < 0.05). No significant relationship was observed between morning blood pressure and nocturnal urination frequency. A high correlation was observed between nighttime urine volume and salt content (r = 0.73, p < 0.001).

    Conclusions

    Nocturnal urine volume, salt content, and urine temperature are significantly correlated with nocturia. The portable urine‐measuring device could guide nocturia reduction through facilitation of the reduction of nocturnal urine volume and salt content, in addition to urine temperature monitoring.

    DOI: 10.1002/nau.25667

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  • Cytotoxic Effects of the Cigarette Smoke Extract of Heated Tobacco Products on Human Oral Squamous Cell Carcinoma: The Role of Reactive Oxygen Species and CaMKK2 Reviewed

    The Journal of Physiological Sciences   74 ( 35 )   2024.6

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    File: Cytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma.pdf

    DOI: 10.1186/s12576-024-00928-1

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  • Relationship between cognitive function and sway of body in standing posture: a cross-sectional study Reviewed

    Naito T, Suzuki Y, Yamasue K, Saito K, Umemura M, Kojima N, Kim H, Osuka Y, Ishikawa Y, Tochikubo O

    Geriatrics   in press   2023.2

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  • Methotrexate-Transferrin-Functionalized Fe(Salen)-Polypyrrole Nanocomposites for Targeted Photo-/Magneto-Thermal Cancer Treatments Reviewed

    Journal of Composites Science   6 ( 5 )   2022.5

  • Store-operated calcium entry via ORAI1 regulates doxorubicin-induced apoptosis and prevents cardiotoxicity in cardiac fibroblasts Reviewed International journal

    Nemoto H, Umemura M, Suzuki1 f, Nagasako A, Nagao K, Hidaka Y, Nakakaji R, Uchida K, Suzuki S, Masuda M, Ishikawa Y

    Plos One   in press ( 12 )   e0278613   2022

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Despite exhibiting cardiotoxicity, doxorubicin (DOX) is widely used for cancer treatments. Cardiac fibroblasts (CFs) are important in the pathogenesis of heart failure. This necessitates the study of the effect of DOX on CFs. The impairment of calcium (Ca2+) homeostasis is a common mechanism of heart failure. Store-operated Ca2+ entry (SOCE) is a receptor-regulated Ca2⁺ entry pathway that maintains calcium balance by sensing reduced calcium stores in the endoplasmic reticulum. ORAI1, a calcium channel protein and the most important component of SOCE, is highly expressed in human cardiac fibroblasts (HCFs). It is upregulated in CFs from failing ventricles. However, whether ORAI1 in HCFs is increased and/or plays a role in DOX-induced cardiotoxicity remains unknown. In this study, we aimed to elucidate the relationship between ORAI1/SOCE and DOX-induced heart failure. Induction of apoptosis by DOX was characterized in HCFs. Apoptosis and cell cycle analyses were performed by fluorescence-activated cell sorting (FACS). Reactive oxygen species (ROS) production was measured using fluorescence. YM-58483 was used as an ORAI1/SOCE inhibitor. ORAI1-knockdown cells were established by RNA interference. In vivo experiments were performed by intraperitoneally injecting YM-58483 and DOX into mice. We first demonstrated that DOX significantly increased the protein expression level of p53 in HCFs by western blotting. FACS analysis revealed that DOX increased early apoptosis and induced cell cycle arrest in the G2 phase in fibroblasts. DOX also increased ROS production. DOX significantly increased the expression level of ORAI1 in CFs. Both YM-58483 and ORAI1 gene knockdown attenuated DOX-induced apoptosis. Similarly, YM-58483 attenuated cell cycle arrest in the G2 phase, and ORAI1 knockdown attenuated DOX-induced ROS production in HCFs. In the animal experiment, YM-58483 attenuated DOX-induced apoptosis. In HCFs, ORAI1/SOCE regulates p53 expression and plays an important role in DOX-induced cardiotoxicity. ORAI1 may serve as a new target for preventing DOX-induced heart failure.

    File: journal.pone.0278613.pdf

    DOI: 10.1371/journal.pone.0278613

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  • Regulators of Epithelial Sodium Channels in Aldosterone-Sensitive Distal Nephrons (ASDN): Critical Roles of Nedd4L/Nedd4-2 and Salt-Sensitive Hypertension. Reviewed International journal

    Tomoaki Ishigami, Tabito Kino, Shintaro Minegishi, Naomi Araki, Masanari Umemura, Hisako Ushio, Sae Saigoh, Michiko Sugiyama

    International journal of molecular sciences   21 ( 11 )   3871 - -   2020.5

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    Ubiquitination is a representative, reversible biological process of the post-translational modification of various proteins with multiple catalytic reaction sequences, including ubiquitin itself, in addition to E1 ubiquitin activating enzymes, E2 ubiquitin conjugating enzymes, E3 ubiquitin ligase, deubiquitinating enzymes, and proteasome degradation. The ubiquitin-proteasome system is known to play a pivotal role in various molecular life phenomena, including the cell cycle, protein quality, and cell surface expressions of ion-transporters. As such, the failure of this system can lead to cancer, neurodegenerative diseases, cardiovascular diseases, and hypertension. This review article discusses Nedd4-2/NEDD4L, an E3-ubiquitin ligase involved in salt-sensitive hypertension, drawing from detailed genetic dissection analysis and the development of genetically engineered mice model. Based on our analyses, targeting therapeutic regulations of ubiquitination in the fields of cardio-vascular medicine might be a promising strategy in future. Although the clinical applications of this strategy are limited, compared to those of kinase systems, many compounds with a high pharmacological activity were identified at the basic research level. Therefore, future development could be expected.

    File: ijms-21-03871.pdf

    DOI: 10.3390/ijms21113871

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  • Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation. Reviewed International journal

    Taro Hiromi, Utako Yokoyama, Daisuke Kurotaki, Al Mamun, Ryo Ishiwata, Yasuhiro Ichikawa, Hiroshi Nishihara, Masanari Umemura, Takayuki Fujita, Shota Yasuda, Tomoyuki Minami, Motohiko Goda, Keiji Uchida, Shinichi Suzuki, Ichiro Takeuchi, Munetaka Masuda, Richard M Breyer, Tomohiko Tamura, Yoshihiro Ishikawa

    Arteriosclerosis, thrombosis, and vascular biology   40 ( 6 )   1559 - 1573   2020.4

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    OBJECTIVE: Excessive prostaglandin E2 production is a hallmark of abdominal aortic aneurysm (AAA). Enhanced expression of prostaglandin E2 receptor EP4 in vascular smooth muscle cells (VSMCs) has been demonstrated in human AAAs. Although moderate expression of EP4 contributes to vascular homeostasis, the roles of excessive EP4 in vascular pathology remain uncertain. We aimed to investigate whether EP4 overexpression in VSMCs exacerbates AAAs. Approach and Results: We constructed mice with EP4 overexpressed selectively in VSMCs under an SM22α promoter (EP4-Tg). Most EP4-Tg mice died within 2 weeks of Ang II (angiotensin II) infusion due to AAA, while nontransgenic mice given Ang II displayed no overt phenotype. EP4-Tg developed much larger AAAs than nontransgenic mice after periaortic CaCl2 application. In contrast, EP4fl/+;SM22-Cre;ApoE-/- and EP4fl/+;SM22-Cre mice, which are EP4 heterozygous knockout in VSMCs, rarely exhibited AAA after Ang II or CaCl2 treatment, respectively. In Ang II-infused EP4-Tg aorta, Ly6Chi inflammatory monocyte/macrophage infiltration and MMP-9 (matrix metalloprotease-9) activation were enhanced. An unbiased analysis revealed that EP4 stimulation positively regulated the genes binding cytokine receptors in VSMCs, in which IL (interleukin)-6 was the most strongly upregulated. In VSMCs of EP4-Tg and human AAAs, EP4 stimulation caused marked IL-6 production via TAK1 (transforming growth factor-β-activated kinase 1), NF-κB (nuclear factor-kappa B), JNK (c-Jun N-terminal kinase), and p38. Inhibition of IL-6 prevented Ang II-induced AAA formation in EP4-Tg. In addition, EP4 stimulation decreased elastin/collagen cross-linking protein LOX (lysyl oxidase) in both human and mouse VSMCs. CONCLUSIONS: Dysregulated EP4 overexpression in VSMCs promotes inflammatory monocyte/macrophage infiltration and attenuates elastin/collagen fiber formation, leading to AAA exacerbation.

    File: atv-40-1559.pdf

    DOI: 10.1161/ATVBAHA.120.314297

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  • The usefulness of exchanged protein directly activated by cAMP (Epac)1-inhibiting therapy for prevention of atrial and ventricular arrhythmias in mice Reviewed

    Prajapati R, Fujita T, Suita K, Nakamura T, Cai W, Hidaka Y, Umemura M, Yokoyama U, Knollmann B, Okumura S, Ishikawa Y

    Circulation journal   83 ( 2 )   295 - 303   2019.2

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    File: 83_CJ-18-0743.pdf

    DOI: 10.1253/circj.CJ-18-0743.

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  • Hybrid metal complex nanocomposites for targeted cancer diagnosis and therapeutics

    Jeong-Hwan Kim, Haruki Eguchi, Masanari Umemura, Yoshihiro Ishikawa

    Materials for Biomedical Engineering: Inorganic Micro- and Nanostructures   427 - 461   2019.1

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    DOI: 10.1016/B978-0-08-102814-8.00015-9

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  • Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor Reviewed International journal

    Umemura M, Islam R, Fukumura H, Sato I, Kawabata Y, Matsuo K, Nakakaji R, Nagasako A, Ohtake M, Fujita T, Yokoyama U, Nakayama T, Eguchi H, Ishikawa Y, correspodence

    Cancer Science   110 ( 1 )   356 - 365   2019.1

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    We previously identified a novel nanomagnetic particle, N,N'-bis(salicylidene)ethylenediamine iron [Fe(Salen)]. Fe(Salen) not only shows antitumor effects but also magnetic properties. We found that Fe(Salen) can be used for magnet-guided drug delivery and visualization of accumulated drug by magnetic resonance imaging (MRI) because of its magnetism. In addition, Fe(Salen) can generate heat by itself when exposed to an alternating current magnetic field (AMF), resulting in a hyperthermia effect. Herein, we partly elucidated the antitumor mechanism of Fe(Salen) and carried out an i.v. repeated dose toxicity study to decide the therapeutic amount. Furthermore, we evaluated the antitumor effect of selective intra-arterial injection or i.v. injection of Fe(Salen) by catheter and the hyperthermia effect of Fe(Salen) when exposed to AMF in vivo. We used a rabbit model grafted with VX2 cells (rabbit squamous cell carcinoma) on the right leg. Intra-arterial injection of Fe(Salen) showed a greater antitumor effect than did i.v. injection. The combination of Fe(Salen) intra-arterial injection and AMF exposure showed a greater antitumor effect than did either Fe(Salen) or methotrexate (MTX) without AMF exposure, suggesting that AMF exposure greatly enhanced the antitumor effect of Fe(Salen) by arterial injection by catheter. This is the first report that the effectiveness of Fe(Salen) was evaluated in the point of administration route; that is, selective intra-arterial injection by catheter. Taken together, these results indicate a new administration route; that is, selective arterial injection of Fe(Salen) by catheter, and the development of a new strategy of simultaneous hyperthermia-chemotherapy in the future.

    File: Umemura_et_al-2018-Cancer_Science.pdf

    DOI: 10.1111/cas.13851

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  • Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling Reviewed

    Masatoshi Narikawa, Masanari Umemura, Ryo Tanaka, Takayuki Fujita, Utako Yokoyama, Tomoaki Ishigami, Kazuo Kimura, Kouichi Tamura, Yoshihiro Ishikawa

    Scientific Reports   8 ( 1 )   2018.12

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nature Publishing Group  

    File: Acute Hyperthermia Inhibits TGFβ1-induced.pdf

    DOI: 10.1038/s41598-018-24749-6

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  • Alternating Magnetic Field (AMF) Enhances Cytotoxicity of Compound C Reviewed International journal

    Akimoto T, Umemura M, Nagasako A, Ohtake M, Fujita F, Yokoyama U, Eguchi H, Yamamoto T, Ishikawa Y, correspondence

    Cancer Science   109 ( 11 )   3483 - 3493   2018.10

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    File: Akimoto_et_al-2018-Cancer_Science.pdf

    DOI: 10.1111/cas.13781.

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  • A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm Reviewed International journal

    Mamun A, Yokoyama U, Saito J, Ito S, Hiromi Ta, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Masuda M, Ishikawa Y

    Pysiological Reports   6 ( 18 )   e13878 - e13878   2018.9

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    File: PHY2-6-e13878.pdf

    DOI: 10.14814/phy2.13878

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  • Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice Reviewed International journal

    Kenji Suita, Takayuki Fujita, Wenqian Cai, Yuko Hidaka, Huiling Jin, Rajesh Prajapati, Masanari Umemura, Utako Yokoyama, Motohiko Sato, Björn C. Knollmann, Satoshi Okumura, Yoshihiro Ishikawa

    Pflugers Archiv European Journal of Physiology   470 ( 6 )   923 - 935   2018.6

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    File: Suita2018_Article_VidarabineAnAnti-herpesvirusAg.pdf

    DOI: 10.1007/s00424-018-2121-4

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  • Hydrostatic pressure suppresses fibrotic changes via Akt/GSK-3 signaling in human cardiac fibroblasts Reviewed International journal

    Ryo Tanaka, Masanari Umemura, Masatoshi Narikawa, Takayuki Fujita, Utako Yokoyama, Tomoaki Ishigami, Kazuo Kimura, Kouichi Tamura, Yoshihiro Ishikawa

    Physiological Reports   6 ( 9 )   e13687   2018.5

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    File: Tanaka_et_al-2018-Physiological_Reports.pdf

    DOI: 10.14814/phy2.13687

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  • Epac activation inhibits IL-6-induced cardiac myocyte dysfunction Reviewed

    Huiling Jin, Takayuki Fujita, Meihua Jin, Reiko Kurotani, Yuko Hidaka, Wenqian Cai, Kenji Suita, Rajesh Prajapati, Chen Liang, Yoshiki Ohnuki, Yasumasa Mototani, Masanari Umemura, Utako Yokoyama, Motohiko Sato, Satoshi Okumura, Yoshihiro Ishikawa

    Journal of Physiological Sciences   68 ( 1 )   77 - 87   2018.1

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    DOI: 10.1007/s12576-016-0509-5

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  • Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus Reviewed International journal

    Junichi Saito, Utako Yokoyama, Naoki Nicho, Yun-Wen Zheng, Yasuhiro Ichikawa, Satoko Ito, Masanari Umemura, Takayuki Fujita, Shuichi Ito, Hideki Taniguchi, Toshihide Asou, Munetaka Masuda, Yoshihiro Ishikawa

    PLoS ONE   13 ( 1 )   e0190871 - -   2018.1

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  • Treatment of oral cancer using magnetized paclitaxel Reviewed International journal

    Rina Nakakaji, Masanari Umemura, Kenji Mitsudo, Jeong-Hwan Kim, Yujiro Hoshino, Itaru Sato, Takatsugu Masuda, Masahiro Yamamoto, Mitomu Kioi, Toshiyuki Koizumi, Takayuki Fujita, Utako Yokoyama, Masaki Iida, Motohiko Sato, Hiroshi Sato, Shoko Murofushi, Sayaka Shibata, Ichio Aoki, Haruki Eguchi, Iwai Tohnai, Yoshihiro Ishikawa

    Oncotarget   9 ( 21 )   15591 - 15605   2018

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    DOI: 10.18632/oncotarget.24570

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  • The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity Reviewed

    Umemura M, Kim JH, Aoyama H, Hoshino Y, Fukumura H, Nakakaji R, Sato I, Ohtake M, Akimoto T, Narikawa M, Tanaka R, Fujita T, Yokoyama U, Taguri M, Okumura S, Sato M, Eguchi H, Ishikawa Y

    JOURNAL OF PHARMACOLOGICAL SCIENCES   134 ( 4 )   203 - 210   2017.8

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    File: The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity.pdf

    DOI: 10.1016/j.jphs.2017.07.002

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  • Transient receptor potential cation 3 channel regulates melanoma proliferation and migration Reviewed

    Oda K, Umemura M, Nakakaji R, Tanaka R, Sato I, Nagasako A, Oyamada C, Baljinnyam E, Katsumata M, Xie LH, Narikawa M, Yamaguchi Y, Akimoto T, Ohtake M, Fujita T, Yokoyama U, Iwatsubo k, Aihara M, Ishikawa Y

    Jornal of Physiological Scinences   67 ( 4 )   497 - 505   2017.7

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    DOI: 10.1007/s12576-016-0480-1

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  • Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway. Reviewed International journal

    Jin H, Fujita T, Meihua Jin, Kurotani R, Namekata I, Hamaguchi S, Hidaka Y, Cai W, Suita K, Ohnuki Y, Mototani Y, Shiozawa K, Prajapati R, Liang C, Umemura M, Yokoyama U, Sato M, Tanaka H, Okumura S, Ishikawa Y

    J Mol Cell Cardiol   108   170-180   2017.6

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    Pro-inflammatory cytokines are released in septic shock and impair cardiac function via the Jak-STAT pathway. It is well known that sympathetic stimulation leads to coupling of the β-adrenergic receptor/Gs/adenylyl cyclase, a membrane-bound enzyme that catalyzes the conversion of ATP to cAMP, thereby stimulating protein kinase A (PKA) and ultimately compensating for cardiac dysfunction. The mechanism of such compensation by catecholamine has been traditionally understood as PKA-mediated enforcement of cardiac contractility. We hypothesized that exchange protein activated by cyclic AMP (Epac), a new target of cAMP signaling that functions independently of protein kinase A, also plays a key role in protection against acute stresses or changes in hemodynamic overload. Lipopolysaccharide injection induced cytokine release and severe cardiac dysfunction in mouse. In mouse overexpressing Epac1 in the heart, however, the magnitude of such dysfunction was significantly smaller. Epac1 overexpression inhibited the Jak-STAT pathway, as indicated by decreased phosphorylation of STAT3 and increased SOCS3 expression, with subsequent inhibition of iNOS expression. In cultured cardiomyocytes treated with isoproterenol or forskolin, the increase of SOCS3 expression was blunted when Epac1 or PKCα was silenced with siRNA. Activation of the cAMP/Epac/PKCα pathway protected the heart against cytokine-induced cardiac dysfunction, suggesting a new role of catecholamine signaling in compensating for cardiac dysfunction in heart failure. Epac1 and its downstream pathways may be novel targets for treating cardiac dysfunction in endotoxemia.

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    DOI: 10.1016/j.yjmcc.2017.05.014.

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  • Magnetic metal-complex-conducting copolymer core-shell nanoassemblies for a single-drug anticancer platform Reviewed International journal

    Kim JH, Eguchi H, Umemura M, Sato I, YamadaS, Hoshino Y, Masuda T, Aoki I, Sakurai K, Yamamoto M, Ishikawa Y

    NPG ASIA MATERIALS   9 ( e367 )   2017.3

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    DOI: 10.1038/am.2017.29

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  • The role of Epac in the heart Reviewed

    Fujita T, Umemura M, Yokoyama U, Okumura S, Ishikawa Y

    Cellular and Molecular Life Sciences   74 ( 4 )   591 - 606   2017.2

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    DOI: 10.1007/s00018-016-2336-5

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  • Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment Reviewed

    Ohtake M, Umemura M, Sato I, Akimoto T, Oda K, Nagasako A, Kim JH, Fujita T, Yokoyama U, Nakayama T, Hoshino Y, Ishiba M, Tokura S, Hara M, Muramoto T, Yamada S, Masuda T, Aoki I, Takemura Y, Murata H, Eguchi H, Kawahara N, Ishikawa Y

    Scientific Reports   7 ( 42783 )   0 - 0   2017.2

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    DOI: 10.1038/srep42783

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  • Arterial graft with elastic layer structure grown from cells Reviewed

    Utako Yokoyama, Yuta Tonooka, Ryoma Koretake, Taisuke Akimoto, Yuki Gonda, Junichi Saito, Masanari Umemura, Takayuki Fujita, Shinya Sakuma, Fumihito Arai, Makoto Kaneko, Yoshihiro Ishikawa

    Scientific Reports   7 ( 1 )   2017

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    DOI: 10.1038/s41598-017-00237-1

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  • Glutamate Promotes Contraction of the Rat Ductus Arteriosus Reviewed

    Fujita S, Yokoyama U, Ishiwata R, Aoki R, Nagao K, Masukawa D, Umemura M, Fujita T, Iwasaki S, Nishimaki S, Seki K, Ito S, Goshima Y, Asou T, Masuda M, Ishikawa Y

    Circulation Journal   80 ( 11 )   2388 - 2396   2016.11

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  • 薬効成分を磁性化した新規タキソールの口腔がん治療への応用

    中鍛治 里奈, 梅村 将就, 佐藤 格, 大竹 誠, 小田 香世子, 光藤 健司, 來生 知, 江口 晴樹, 藤内 祝, 石川 義弘

    日本癌学会総会記事   75回   P - 3274   2016.10

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  • Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction Reviewed

    Wenqian Cai, Takayuki Fujita, Yuko Hidaka, Huiling Jin, Kenji Suita, Rajesh Prajapati, Chen Liang, Masanari Umemura, Utako Yokoyama, Motohiko Sato, Satoshi Okumura, Yoshihiro Ishikawa

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   475 ( 1 )   1 - 7   2016.6

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    DOI: 10.1016/j.bbrc.2016.04.123

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  • Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles Reviewed

    Sato I, Umemura M, Mitsudo K, Fukumura H, Kim JH, Hoshino Y, Nakashima H, Kioi M, Nakakaji R, Sato M, Fujita T, Yokoyama U, Okumura S, Oshiro H, Eguchi H, Tohnai I, Ishikawa Y

    Scientific Reports   6 ( 24629 )   0 - 0   2016.4

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    DOI: 10.1038/srep24629

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  • Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation Reviewed

    Yuko Kato, Utako Yokoyama, Chiharu Yanai, Rina Ishige, Daisuke Kurotaki, Masanari Umemura, Takayuki Fujita, Tetsuo Kubota, Satoshi Okumura, Masataka Sata, Tomohiko Tamura, Yoshihiro Ishikawa

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   35 ( 12 )   2617 - 2625   2015.12

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  • Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through beta 1-and alpha 1-Adrenergic Receptor-Mediated Signaling in Mice Reviewed

    Kenji Suita, Takayuki Fujita, Nozomi Hasegawa, Wenqian Cai, Huiling Jin, Yuko Hidaka, Rajesh Prajapati, Masanari Umemura, Utako Yokoyama, Motohiko Sato, Satoshi Okumura, Yoshihiro Ishikawa

    PLOS ONE   10 ( 7 )   e0133664   2015.7

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  • Coupling of beta(1)-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes Reviewed

    Takashi Tsunematsu, Satoshi Okumura, Yasumasa Mototani, Yoshiki Ohnuki, Huiling Jin, Wenqian Cai, Kenji Suita, Itaru Sato, Masanari Umemura, Utako Yokoyama, Motohiko Sato, Takayuki Fujita, Yoshihiro Ishikawa

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   458 ( 3 )   531 - 535   2015.3

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    DOI: 10.1016/j.bbrc.2015.01.149

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  • Decreased serum osmolality promotes ductus arteriosus constriction Reviewed

    Rika Aoki, Utako Yokoyama, Yasuhiro Ichikawa, Masataka Taguri, Shun Kumagaya, Ryo Ishiwata, Chiharu Yanai, Shujiro Fujita, Masanari Umemura, Takayuki Fujita, Satoshi Okumura, Motohiko Sato, Susumu Minamisawa, Toshihide Asou, Munetaka Masuda, Shiho Iwasaki, Shigeru Nishimaki, Kazuo Seki, Shumpei Yokota, Yoshihiro Ishikawa

    CARDIOVASCULAR RESEARCH   104 ( 2 )   326 - 336   2014.11

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  • Genetic variation in NEDD4L, salt sensitivity, and hypertension: human NEDD4L rs4149601 G allele generates evolutionary new isoform I with C2 domain. Reviewed International journal

    Tomoaki Ishigami, Naomi Araki, Shintaro Minegishi, Masanari Umemura, Satoshi Umemura

    Journal of hypertension   32 ( 9 )   1905 - 1905   2014.9

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    DOI: 10.1097/HJH.0000000000000293

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  • Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling Reviewed

    Erdene Baljinnyam, Masanari Umemura, Christine Chuang, Mariana S. De Lorenzo, Mizuka Iwatsubo, Suzie Chen, James S. Goydos, Yoshihiro Ishikawa, John M. Whitelock, Kousaku Iwatsubo

    PIGMENT CELL & MELANOMA RESEARCH   27 ( 4 )   611 - 620   2014.7

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  • Identification of Bona Fide Alternative Renin Transcripts Expressed Along Cortical Tubules and Potential Roles in Promoting Insulin Resistance In Vivo Without Significant Plasma Renin Activity Elevation Reviewed

    Tomoaki Ishigami, Tabito Kino, Lin Chen, Shintaro Minegishi, Naomi Araki, Masanari Umemura, Kaito Abe, Rie Sasaki, Hisako Yamana, Satoshi Umemura

    HYPERTENSION   64 ( 1 )   125 - 133   2014.7

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    DOI: 10.1161/HYPERTENSIONAHA.114.03394

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  • Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses Reviewed

    Okumura S, Fujita T, Cai W, Jin M, Namekata L, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y

    Journal of Clinical Investigation   124 ( 6 )   2785 - 2801   2014.6

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    File: Epac1-dependent phospholamban.pdf

    DOI: 10.1172/JCI64784

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  • Hyperthermia generated with ferucarbotran (Resovist(A (R))) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells Reviewed

    Itaru Sato, Masanari Umemura, Kenji Mitsudo, Mitomu Kioi, Hideyuki Nakashima, Toshinori Iwai, Xianfeng Feng, Kayoko Oda, Akiyoshi Miyajima, Ayako Makino, Maki Iwai, Takayuki Fujita, Utako Yokoyama, Satoshi Okumura, Motohiko Sato, Haruki Eguchi, Iwai Tohnai, Yoshihiro Ishikawa

    JOURNAL OF PHYSIOLOGICAL SCIENCES   64 ( 3 )   177 - 183   2014.5

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    DOI: 10.1007/s12576-014-0309-8

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  • Three-dimensional multilayers of smooth muscle cells as a new experimental model for vascular elastic fiber formation studies Reviewed

    Ryo Ishiwata, Utako Yokoyama, Michiya Matsusaki, Yoshiya Asano, Koji Kadowaki, Yasuhiro Ichikawa, Masanari Umemura, Takayuki Fujita, Susumu Minamisawa, Hiroshi Shimoda, Mitsuru Akashi, Yoshihiro Ishikawa

    ATHEROSCLEROSIS   233 ( 2 )   590 - 600   2014.4

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    DOI: 10.1016/j.atherosclerosis.2014.01.045

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  • A case of R-II-B type single coronary artery evaluated by multi-detector computed tomography and coronary angiography. Reviewed

    Narikawa M, Kiyokuni M, Umemura M, Kawashima C, Doi H, Hisa A, Tomari S, Mitsuhashi T, Ishikawa Y, Endo T

    Journal of Clinical and Experimental Cardiology   5 ( 10 )   2014

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  • The Prostanoid EP4 Receptor and Its Signaling Pathway Reviewed

    Utako Yokoyama, Kousaku Iwatsubo, Masanari Umemura, Takayuki Fujita, Yoshihiro Ishikawa

    PHARMACOLOGICAL REVIEWS   65 ( 3 )   1010 - 1052   2013.7

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    File: The Prostanoid EP4 Receptor and Its Signaling Pathway.pdf

    DOI: 10.1124/pr.112.007195

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  • Recent advance in isoform-specific regulation of adenylyl cyclase Reviewed

    David Wei-Kang Ho, Masanari Umemura, Claudio Bravo, Kousaku Iwatsubo

    Current Enzyme Inhibition   8 ( 2 )   170 - 182   2012.9

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    File: Recent Advance in Isoform-Specific Regulation of Adenylyl Cyclase.pdf

    DOI: 10.2174/157340812800793282

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  • Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase Reviewed

    Kosaku Iwatsubo, Claudio Bravo, Masami Uechi, Erdene Baljinnyam, Takashi Nakamura, Masanari Umemura, Lo Lai, Shumin Gao, Lin Yan, Xin Zhao, Misun Park, Hongyu Qiu, Satoshi Okumura, Mizuka Iwatsubo, Dorothy E. Vatner, Stephen F. Vatner, Yoshihiro Ishikawa

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   302 ( 12 )   H2622 - H2628   2012.6

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    File: Prevention of heart failure in mice by an antiviral agent.pdf

    DOI: 10.1152/ajpheart.00190.2012

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  • Acute myocardial infarction with isolated conus branch occlusion

    Masanari Umemura, David Ho, Naoki Nozawa, Erdene Balginnyam, Kousaku Iwatsubo, Thosihiko Saito, Tsutomu Endo, Yoshihiro Ishikawa, Satoshi Umemura, Kazuo Kimura

    JOURNAL OF ELECTROCARDIOLOGY   45 ( 3 )   285 - 287   2012.5

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    DOI: 10.1016/j.jelectrocard.2011.11.006

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  • Acute pulmonary embolism induced by renal obstruction with benign prostatic hyperplasia: Case report

    Masanari Umemura, David Ho, Naoki Nozawa, Erdene Balginnyam, Kousaku Iwatsubo, Toshihiko Saito, Tsutomu Endo, Yoshihiro Ishikawa, Satoshi Umemura, Kazuo Kimura

    Journal of Cardiology Cases   5 ( 1 )   e39 - e43   2012.2

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    File: Acute pulmonary embolism induced by renal.pdf

    DOI: 10.1016/j.jccase.2011.10.004

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  • Renin Angiotensin Antagonists Normalize Aberrant Activation of Epithelial Sodium Channels in Sodium-Sensitive Hypertension Reviewed

    Hisako Ushio-Yamana, Shintaro Minegishi, Tomoaki Ishigami, Naomi Araki, Masanari Umemura, Koichi Tamura, Emi Maeda, Yutaka Kakizoe, Kenichiro Kitamura, Satoshi Umemura

    NEPHRON EXPERIMENTAL NEPHROLOGY   122 ( 3-4 )   95 - 102   2012

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    DOI: 10.1159/000348660

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  • Epac1 promotes melanoma metastasis via modification of heparan sulfate Reviewed

    Erdene Baljinnyam, Masanari Umemura, Mariana S. De Lorenzo, Mizuka Iwatsubo, Suzie Chen, James S. Goydos, Kousaku Iwatsubo

    PIGMENT CELL & MELANOMA RESEARCH   24 ( 4 )   680 - 687   2011.8

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    DOI: 10.1111/j.1755-148X.2011.00863.x

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  • G beta gamma subunits inhibit Epac-induced melanoma cell migration Reviewed

    Erdene Baljinnyam, Masanari Umemura, Mariana S. De Lorenzo, Lai-Hua Xie, Martha Nowycky, Mizuka Iwatsubo, Suzie Chen, James S. Goydos, Kousaku Iwatsubo

    BMC CANCER   11 ( 256 )   doi: 10.1186/1471-2407-11-256.   2011.6

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    File: Gbg subunits inhibit Epac-induced melanoma.pdf

    DOI: 10.1186/1471-2407-11-256

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  • Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L Reviewed

    Naomi Araki, Tomoaki Ishigami, Hisako Ushio, Shintaro Minegishi, Masanari Umemura, Yohei Miyagi, Ichiro Aoki, Hiroko Morinaga, Koichi Tamura, Yoshiyuki Toya, Kazuaki Uchino, Satoshi Umemura

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   388 ( 2 )   290 - 296   2009.10

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    DOI: 10.1016/j.bbrc.2009.07.158

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  • Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant - Implications for essential hypertension Reviewed

    Naomi Araki, Masanari Umemura, Yohei Miyagi, Machiko Yabana, Yuko Miki, Koichi Tamura, Kazuaki Uchino, Reina Aoki, Yoshio Goshima, Satoshi Umemura, Tomoaki Ishigami

    HYPERTENSION   51 ( 3 )   773 - 777   2008.3

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    DOI: 10.1161/HYPERTENSIONAHA.107.102061

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  • NEDD4L protein truncating variant (v13[G/A]: rs4149601) is associated with essential hypertension in a sample of the Japanese population Reviewed

    Tomoaki Ishigami, Masanari Umemura, Naomi Araki, Nobuhito Hirawa, Koichi Tamura, Kazuaki Uchino, Satoshi Umemura, Andreas Rohrwasser, Jean-Marc Lalouel

    GERIATRICS & GERONTOLOGY INTERNATIONAL   7 ( 2 )   114 - 117   2007.6

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    DOI: 10.1111/j.1447-0594.2007.00382.x

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  • The novel angiotensin II type I receptor (ATIR)-associated protein ATRAP downregulates ATIR and ameliorates cardiomyocyte hypertrophy Reviewed International journal

    Y Tanaka, K Tamura, Y Koide, M Sakai, Y Tsurumi, Y Noda, M Umemura, T Ishigamia, K Uchino, K Kimura, M Horiuchi, S Umemura

    FEBS LETTERS   579 ( 7 )   1579 - 1586   2005.3

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    DOI: 10.1016/j.febslet.2005.01.068

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  • Acute renal failure due to cholesterol crystal embolism treated with LDL apheresis followed by corticosteroid and candesartan Reviewed

    Kouichi Tamura, Masanari Umemura, Hideto Yano, Masashi Sakai, Yoko Sakurai, Yuko Tsurumi, Yuichi Koide, Takashi Usui, Machiko Yabana, Yoshiyuki Toya, Yasuo Tokita, Satoshi Umemura

    Clinical and Experimental Nephrology   7 ( 1 )   67 - 71   2003.3

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    DOI: 10.1007/s101570300010

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Books

  • 生理学用語ハンドブック

    監修: 日本生理学 編集: 日本生理学会用語委員会( Role: Contributor循環器)

    丸善出版  2024.3 

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  • Materials for Biomedical Engineering: Inorganic Micro and Nanostructures

    Kim J-H, Eguchi H, Umemura M, Ishikawa Y( Role: ContributorChapter 13 Hybrid metal nanocomposites for theranostic drug delivery)

    Elsevier  2019 

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  • Guyton and Hall Textbook of Medical Physiology

    Umemura Masanari( Role: ContributorChapter 9-11)

    (Elsevier  2018.3 

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  • 看護:下大静脈フィルター

    梅村将就, 猿渡力( Role: Contributor)

    日本看護協会出版会  2008 

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  • 治療:外科手術のための心機能評価はどこまで必要か?

    梅村 将就( Role: Contributor何が正解? 循環器治療.EBMで検証(24))

    南山堂  2006 

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MISC

  • Alternative Magnetic Field Exposure Inhibits Tumor Growth in Glioblastoma Through Metabolic Reprogramming

    梅村将就, 岸和人, 永迫茜, 秋本大輔, 大竹誠, 中鍛治里奈, 山本哲哉

    日本癌学会学術総会抄録集(Web)   83rd   2024

  • 口腔がん細胞におけるEP4受容体のミトコンドリア生合成を介した遊走調節機構の解明

    石川 聡一郎, 梅村 将就, 中鍛治 里奈, 永迫 茜, 大澤 昂平, 深江 和奏, 山下 絵利子, 光藤 健司, 石川 義弘

    日本病態生理学会雑誌   32 ( 2 )   40 - 40   2023.7

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  • 口腔がん細胞遊走におけるEP4受容体のCa2+シグナルを介したメカニズムの解明

    石川 聡一郎, 梅村 将就, 中鍛治 里奈, 永迫 茜, 大澤 昂平, 來生 知, 光藤 健司, 石川 義弘

    日本病態生理学会雑誌   31 ( 2 )   23 - 23   2022.7

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  • ラット心臓横紋筋におけるドキソルビシンの心毒性メカニズムの解析

    鈴木 文菜, 梅村 将就, 内野 萌, 根本 寛子, 日高 祐子, 永迫 茜, 中鍛治 里奈, 石川 義弘

    日本病態生理学会雑誌   30 ( 2 )   41 - 41   2021.12

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  • 心臓線維芽細胞におけるOrai1を介したドキソルビシン関連心不全の新たな機序

    根本 寛子, 梅村 将就, 中鍛治 里奈, 永迫 茜, 長尾 景充, 日高 祐子, Islam Rafikul, 鈴木 文菜, 鈴木 伸一, 石川 義弘

    日本病態生理学会雑誌   30 ( 2 )   36 - 36   2021.12

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  • 市販医薬品の薬効成分を磁性化する画期的技術の開発

    梅村 将就, 中鍛治 里奈, 永迫 茜, Islam Md Rafikul, 大竹 誠, 長尾 景充, 根本 寛子, 水野 雄斗, 石川 聡一郎, 鈴木 文菜, 石川 義弘

    横浜医学   72 ( 4 )   537 - 544   2021.10

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  • 悪性骨軟部腫瘍に対し交流磁場と磁性抗がん剤を用いた新しい化学・温熱同時療法

    川端 佑介, 梅村将就, 松尾光祐, 福村英信, 林田健太, 竹山昌伸, 石川義弘, 稲葉 裕

    整形外科   72 ( 8 )   868   2021.7

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  • Doxorubicin directly induced fibrotic change of cardiac fibroblasts Invited

    Umemura Masanari, Narikawa Masatoshi, Tanaka Ryo, Nemoto Hiroko, Nakakaji Rina, Nagasako Akane, Ishikawa Yoshihiro

    Folia Pharmacologica Japonica   156 ( 3 )   146 - 151   2021.5

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    Doxorubicin (DOX)-induced cardiomyopathy has a poor prognosis. No early detection or effective treatment methods are available in clinical. The mechanisms of cardiotoxicity were considered as oxidative stress and apoptosis in cardiomyocytes. However, the effect of DOX on cardiac fibroblasts remains to be developed. We investigated the direct effect of DOX on the function of human cardiac fibroblasts (HCFs) independently of cell death pathway. Animal study showed that lower dose of DOX (4 mg/kg/week for 3 weeks, <i>i.p.</i>) than a toxic cumulate dose, induced perivascular fibrosis without cell death in hear of mice. DOX increased the protein expression of α-SMA (a marker of trans-differentiation) in HCFs culture cells, indicating that DOX promoted the trans-differentiation of HCFs into myofibroblast. DOX also increased the mRNA and protein expression of matrix metalloproteinase (MMP)-1 in less than 0.1 μM which did not induce cell apoptosis of HCFs cells via PI3K/Akt pathway in HCFs. DOX increased Interleukin-6 (IL-6) via transforming growth factor (TGF)-β/Smad pathway. In addition, DOX induced the mitochondrial damage and increased the expression of Interleukin-1 (IL-1) via stress-activated protein kinases (SAPK)/ c-Jun NH-2termial kinase (JNK). A peroxisome proliferator-activated receptor gamma (PPARγ) agonist, pioglitazone hydrochloride attenuated the expression of fibrotic marker such as α-SMA and galectin-3 and collagen1 via SAPK/JNK signaling. Pioglitazone also suppressed DOX-induced early fibrotic response in vivo. In conclusion, these findings suggested that low dose DOX induced reactive fibrotic change of cardiac fibroblasts via cell death-independent pathway. There may be potentially new mechanisms of DOX induced cardiotoxicity in clinical usage.

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    Other Link: http://id.ndl.go.jp/bib/031499535

  • 市販医薬品の薬効成分を磁性化する画期的技術の開発 Invited

    梅村 将就, 中鍛治 里奈, 永迫 茜, Md Rafikul Islam, 大竹 誠, 長尾 景充, 根本 寛子, 水野 雄斗, 石川 聡一郎, 鈴木 文菜, 石川 義弘

    横浜医学   72 ( 4 )   537 - 544   2021

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    File: 市販医薬品の薬効成分を磁性化する画期的技術の開発.pdf

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  • 産学連携から生まれた市販医薬品磁性化技術を臨床応用するための研究 Invited

    梅村 将就

    臨床薬理の進歩   ( 40 )   35 - 44   2019.6

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  • 急性と慢性:心不全はどこがちがうのか?

    石川義弘, 藤田孝之, 梅村将就, 横山詩子

    Shock   33 ( 2 )   34‐39   2019.2

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  • アストロサイトに対するAMPK阻害と交流磁場併用効果についての腫瘍細胞との比較検討

    秋本大輔, 梅村将就, 石川義弘, 山本哲哉

    脳循環代謝(Web)   31 ( 1 )   2019

  • 薬効成分を磁性化した新規パクリタキセルを用いた口腔がん治療の開発

    中鍛治 里奈, 梅村 将就, 大竹 誠, 來生 知, 江口 晴樹, 藤内 祝, 石川 義弘

    日本癌学会総会記事   76回   P - 1436   2017.9

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  • 温熱刺激は、Akt/S6K経路を介して心臓線維芽細胞の活性化を抑制する

    成川 雅俊, 梅村 将就, 木村 一雄, 田村 功一, 石川 義弘

    日本心臓病学会学術集会抄録   65回   O - 054   2017.9

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  • Magnetized methotrexate for novel anti-cancer therapy

    Mayumi Katsumata, Masanari Umemura, Itaru Sato, Makoto Ohtake, Kayoko Oda, Taisuke Akimoto, Rina Nakakaji, Masatoshi Narikawa, Haruki Aoyama, Haruki Eguchi, Yoshihiro Ishikawa

    JOURNAL OF PHARMACOLOGICAL SCIENCES   130 ( 3 )   S186 - S186   2016.3

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  • Magnetized Votrient derivative for novel anti-cancer therapy

    Haruki Aoyama, Masanari Umemura, Itaru Sato, Makoto Ohtake, Kayoko Oda, Taisuke Akimoto, Masatoshi Narikawa, Rina Nakakaji, Mayumi Katsumata, Haruki Eguchi, Yoshihiro Ishikawa

    JOURNAL OF PHARMACOLOGICAL SCIENCES   130 ( 3 )   S186 - S186   2016.3

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  • Novel thermo-chemotherapy for oral cancer using a new magnetic anti-cancer drug

    I. Sato, M. Umemura, K. Mitsudo, H. Nakashima, M. Kioi, H. Eguchi, M. Ohtake, K. Oda, R. Nakakaji, I. Tohnai, Y. Ishikawa

    EUROPEAN JOURNAL OF CANCER   51   S561 - S561   2015.9

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  • Simultaneous hyperthermic-chemotherapy for glioblastoma using a single anti-cancer compound with intrinsic magnetism

    Makoto Ohtake, Masanari Umemura, Itaru Sato, Kayoko Oda, Akane Nagasako, Ayako Makino, Haruki Aoyama, Mayumi Katsumata, Haruki Eguchi, Nobutaka Kawahara, Yoshihiro Ishikawa

    CANCER RESEARCH   75   2015.8

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    DOI: 10.1158/1538-7445.AM2015-4548

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  • Methotrexate derivative with intrinsic magnetism

    Masanari Umemura, Mayumi Katsumata, Itaru Sato, Akane Nagasako, Haruki Aoyama, Ayako Makino, Makoto Ohtake, Kayoko Oda, Kosuke Matsuo, Haruki Eguchi, Yoshihiro Ishikawa

    CANCER RESEARCH   75   2015.8

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    DOI: 10.1158/1538-7445.AM2015-4398

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  • Transient receptor potential cation channel 3 (TRPC3) regulates tumor proliferation and migration of BRAF wild type human malignant melanoma

    Kayoko Oda, Masanari Umemura, Mayumi Katsumata, Haruki Aoyama, Ayako Makino, Makoto Ohtake, Itaru Sato, Yukie Yamaguchi, Yoji Nagashima, Michiko Aihara, Yoshihiro Ishikawa, Akane Nagasako

    CANCER RESEARCH   75   2015.8

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    DOI: 10.1158/1538-7445.AM2015-4371

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  • 心肥大と心不全

    石川 義弘, 藤田 孝之, 梅村 将就, 横山 詩子

    日本病態生理学会雑誌   24 ( 1 )   28 - 38   2015.5

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  • Development of thermochemotherapy using cisplatin and ferucarbotran (Resovist (R)) in head and neck cancer

    Itaru Sato, Masanari Umemura, Kenji Mitsudo, Xianfeng Feng, Hideyuki Nakashima, Mitomu Kioi, Akiyoshi Miyajima, Haruki Eguchi, Iwai Tohnai, Yoshihiro Ishikawa

    CANCER RESEARCH   74 ( 19 )   2014.10

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    DOI: 10.1158/1538-7445.AM2014-4576

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  • A novel treatment for triple-negative breast cancer using intrinsic magnetized paclitaxel

    Masanari Umemura, Ayako Makino, Itaru Sato, Xianfeng Feng, Kayoko Oda, Makoto Ohtake, Satoshi Izuka, Maki Iwai, Kosuke Matsuo, Haruki Eguchi, Yoshihiro Ishikawa

    CANCER RESEARCH   74 ( 19 )   2014.10

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    DOI: 10.1158/1538-7445.AM2014-5399

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  • MRI造影剤フェルカルボトランを用いた新しい温熱化学療法の開発

    佐藤 格, 光藤 健司, 梅村 将就, 宮島 章嘉, 中島 英行, 來生 知, 石川 義弘, 藤内 祝

    頭頸部癌   40 ( 2 )   271 - 271   2014.5

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  • 腎および肺疾患の標的としての上皮イオンチャネル研究の最前線 Nedd4Lおよび尿細管レニン-アンジオテンシン系を介したENaC発現機能制御

    石上 友章, 梅村 将就, 新城 名保美, 峯岸 慎太郎, 山名 比早子

    日本薬学会年会要旨集   134年会 ( 1 )   257 - 257   2014.3

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  • 新規磁性体抗癌剤の抗腫瘍効果とそのメカニズム

    佐藤 格, 光藤 健司, 梅村 将就, 宮島 章嘉, 中島 英行, 來生 知, 石川 義弘, 藤内 祝

    Thermal Medicine   30 ( 1 )   21 - 21   2014.3

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  • Thermochemotherapy with controlled drug delivery using a novel magnetic anti-cancer drug

    Itaru Sato, Kenji Mitsudo, Masanari Umemura, Xianfeng Feng, Hidenobu Fukumura, Haruki Eguchi, Hideyuki Nakashima, Mitomu Kioi, Iwai Tohnai, Yoshihiro Ishikawa

    CANCER RESEARCH   73 ( 8 )   2013.4

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    DOI: 10.1158/1538-7445.AM2013-5568

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  • Development of a novel magnetic anticancer drug for hyperthermic therapy

    Masanari Umemura, Hidenobu Fukumura, Itaru Sato, Xianfeng Feng, Haruki Eguchi, Yoshihiro Ishikawa

    CANCER RESEARCH   73 ( 8 )   2013.4

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    DOI: 10.1158/1538-7445.AM2013-5567

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  • The function of Store-operated Ca2+ entry(SOCE)in melanoma

    Masanari Umemura, Takayuki Fujita, Utako Yokoyama, Yoshihiro Ishikawa, Kousaku Iwatsubo

    JOURNAL OF PHYSIOLOGICAL SCIENCES   63   S74 - S74   2013

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  • Chemotherapeutic and drug delivery systemwith a novel nano-magnetic particle, EI236

    Hitoshi Iizuka, Masanari Umemura, Itaru Sato, Feng Xianfeng, Haruki Eguchi, Yoshihiro Ishikawa

    JOURNAL OF PHYSIOLOGICAL SCIENCES   63   S225 - S225   2013

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  • Effects of anti-cancer using a novel magnetic nanoparticle

    Itaru Sato, Masanari Umemura, Kenji Mitsudo, Feng Xianfeng, Hitoshi Iizuka, Haruki Eguchi, Iwai Tohnai, Yoshihiro Ishikawa

    JOURNAL OF PHYSIOLOGICAL SCIENCES   63   S210 - S210   2013

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  • 食塩感受性高血圧の成因における尿細管レニンアンジオテンシン系の役割についての検討

    峯岸 慎太郎, 山名 比早子, 石上 友章, 新城 名保美, 梅村 将就, 内野 和顕, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   35回   517 - 517   2012.9

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  • Role of store-operated Ca2+entry in proliferation and cell cycle in melanoma

    Masanari Umemura, Erdene Baljinnyam, Mariana S. De Lorenzo, Stefan Feske, Lai-Hua Xie, Kousaku Iwatsubo

    CANCER RESEARCH   72   2012.4

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    DOI: 10.1158/1538-7445.AM2012-1864

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  • Nedd4L C2ドメインノックアウトマウスの作成と表現型の解析

    峯岸 慎太郎, 石上 友章, 山名 比早子, 新城 名保美, 梅村 将就, 内野 和顕, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   34回   401 - 401   2011.10

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  • 新規家庭血圧計を用いた推定基底血圧の評価についての検討

    大島 聡人, 石上 友章, 峯岸 慎太郎, 山名 比早子, 新城 名保美, 梅村 将就, 内野 和顕, 梅村 敏, 藤川 哲也

    日本高血圧学会総会プログラム・抄録集   34回   599 - 599   2011.10

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  • 尿細管イオントランスポーターの翻訳後修飾に着目した高血圧症の食塩感受性の分子機序の検討

    石上 友章, 峯岸 慎太郎, 山名 比早子, 内野 和顕, 戸谷 義幸, 梅村 将就, 新城 名保美, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   34回   374 - 374   2011.10

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  • G beta gamma subunits inhibit Epac-induced melanoma cell migration

    Erdene Baljinnyam, Masanari Umemura, Lai-Hua Xie, Martha Nowycky, Kousaku Iwatsubo

    CANCER RESEARCH   71   2011.4

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  • Role of Orai1 and STIM1 in store-operated Ca2+entry and cell migration in melanoma

    Masanari Umemura, Erdene Baljinnyam, Lai-Hua Xie, Stefan Feske, Martha Nowycky, Kosaku Iwatsubo

    CANCER RESEARCH   71   2011.4

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    DOI: 10.1158/1538-7445.AM2011-5259

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  • Epac1 activates migration of melanoma and angiogenesis of endothelial cells via FGF-2 intercellular signaling

    Erdene Baljinnyam, Masanari Umemura, Mariana S. De Lorenzo, Kousaku Iwatsubo

    CANCER RESEARCH   71   2011.4

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    DOI: 10.1158/1538-7445.AM2011-3664

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  • A NEW PROGRAMMABLE HOME BLOOD PRESSURE MONITORING DEVICE FOR THE ASSESSMENT OF NIGHTTIME BLOOD PRESSURE OF TOTAL 40 NORMOTENSIVE SUBJECTS

    T. Ishigami, H. Ushio, S. Minegishi, N. Araki, M. Umemura, K. Tamura, K. Uchino, S. Umemura

    JOURNAL OF HYPERTENSION   28   E208 - E208   2010.6

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  • ANGIOTENSIN II INDUCED SCN5A-NEDD4L TRANSCRIPTIONAL ACTIVATION WITH MINERAL CORTICOID RECEPTOR TRANSACTIVATION IN CARDIOMYOCYTES

    S. Minegishi, T. Ishigami, H. Ushio, N. Araki, M. Umemura, Y. Toya, K. Uchino, S. Umemura

    JOURNAL OF HYPERTENSION   28   E351 - E351   2010.6

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  • Identification of binding proteins for human Nedd4L C2 domain

    N. Araki, T. Ishigami, M. Umemura, K. Tamura, K. Uchino, S. Umemura

    JOURNAL OF HYPERTENSION   26   S138 - S138   2008.6

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  • OE-061 Cardiorenal Relationship-A role of Na channel-Nedd4L-proteasome system for essential hypertension and angiotensin II (All) induced transcriptional changes in cardiomyocyte.(Hypertension, basic(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Ishigami Tomoaki, Araki Naomi, Tamura Koichi, Umemura Masanari, Uchino Kazuaki, Umemura Satosih

    Circulation journal : official journal of the Japanese Circulation Society   72   195 - 195   2008.3

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  • 69)ヘパリン開始後早期に血小板減少を生じた急性肺血栓塞栓症の1例(第203回日本循環器学会関東甲信越地方会)

    坂 賢一郎, 猿渡 力, 井出 桜, 川浦 範之, 梅村 将就, 邑山 美奈子, 野澤 直樹

    Circulation journal : official journal of the Japanese Circulation Society   71   941 - 941   2007.10

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  • 急性肺血栓塞栓症における一時的下大静脈フィルターの有効性と合併症

    猿渡 力, 野澤 直樹, 邑山 美奈子, 川浦 範之, 梅村 将就, 坂 賢一郎, 井出 桜, 奥田 純, 日比 潔, 木村 一雄

    Therapeutic Research   28 ( 6 )   1036 - 1037   2007.6

  • 循環虚脱を伴う重症肺血栓塞栓症におけるPCPS装着中の呼吸循環動態に関する検討

    猿渡 力, 野澤 直樹, 邑山 美奈子, 川浦 範之, 梅村 将就, 坂 賢一郎, 井出 桜, 奥田 純, 日比 潔, 木村 一雄

    Therapeutic Research   28 ( 6 )   1110 - 1112   2007.6

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  • 急性肺血栓塞栓症における一時的下大静脈フィルターの有効性と合併症

    猿渡 力, 井出 桜, 坂 賢一郎, 梅村 将就, 川浦 範之, 野澤 直樹, 奥田 純, 日比 潔, 木村 一雄

    静脈学   18 ( 2 )   98 - 98   2007.5

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  • OE-276 Transcriptional Regulation of Human Nedd4L Gene Isoform I and Development of Essential Hypertension(Hypertension, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

    Ishigami Tomoaki, Umemura Masanari, Araki Naomi, Tamura Koichi, Uchino Kazuaki, Umemura Satoshi

    Circulation journal : official journal of the Japanese Circulation Society   71   220 - 220   2007.3

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  • Transcriptional diversity and expression of Nedd4L gene in distal nephrowits implications for sodium sensitive hypertension in rat.

    Masanari Umemura, Tomoaki Ishigami, Naomi Araki, Koichi Tamura, Masashi Sakai, Kazuaki Uchino, Andreas Rohrwasser, Jean-Marc Lalouel, Satoshi Umemura

    JOURNAL OF HYPERTENSION   24   104 - 104   2006.12

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  • The effects of leptin receptor gene polymorphism on visceral fat accumulation and blood pressure.

    Momoko Ogawa, Nobuhito Hirawa, Tadasi Shiwa, Teruhiko Endo, Masanari Umemura, Keisuke Yatsu, Sanae Saka, Kouichi Tamura, Tomoaki Ishigami, Gen Yasuda, Yoshiyuki Toya, Yasuharu Tabara, Tetsuro Miki, Katsuji Tokunaga, Satoshi Umemura

    JOURNAL OF HYPERTENSION   24   285 - 285   2006.12

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  • 重症肺血栓塞栓症におけるPCPS装着中の呼吸循環動態に関する検討

    猿渡 力, 野澤 直樹, 邑山 美奈子, 川浦 範之, 梅村 将就, 坂 賢一郎, 井出 桜, 奥田 純, 日比 潔, 木村 一雄, 梅村 敏

    Journal of Cardiology   48 ( Suppl.I )   662 - 662   2006.9

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  • 何が正解? 循環器治療 EBMで検証(24)外科手術のための心機能評価はどこまで必要か?

    梅村 将就, 石上 友章, 内野 和顕

    治療   88 ( 6 )   1818 - 1825   2006.6

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  • 106)深部静脈血栓症を発症し診断に至った先天性AT III欠乏症合併妊娠の一例(第197回日本循環器学会関東甲信越地方会)

    小川 英幸, 内野 和顕, 三樹 裕子, 重永 豊一郎, 梅村 将就, 志村 美英, 泰磨 美能留, 松本 克己, 松下 浩平, 川崎 典子, 仲沢 一郎, 小林 司, 菅野 晃靖, 石上 友章, 石川 利之, 梅村 敏

    Circulation journal : official journal of the Japanese Circulation Society   70   1032 - 1032   2006.4

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  • PE-399 Expression of Angiotensinogen in Proximal Tubule as a Function of Glomerular Filtrate-role of Tubular RAS for Development of Essential Hypertension(Hypertension, basic-2 (H) PE67,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

    Ishigami Tomoaki, Umemura Masanari, Miki Yuko, Araki Naomi, Tamura Koichi, Gociman Barubu, Andreas Rohrwasser, Marc Lalouel Jean, Uchino Kazuaki, Umemura Satoshi

    Circulation journal : official journal of the Japanese Circulation Society   70   433 - 433   2006.3

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  • PE-400 Common Variant of Human NEDD4L Activates a Cryptic Splice Site to Form a Frameshift Transcript(Hypertension, basic-2 (H) PE67,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

    Ishigami Tomoaki, Umemura Masanari, Araki Naomi, Miki Yuko, Tamura Koichi, Uchino Kazuaki, Marc Lalouel Jean, Umemura Satoshi

    Circulation journal : official journal of the Japanese Circulation Society   70   433 - 433   2006.3

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  • 【分子高血圧 最新の進歩】 本態性高血症に対する尿細管レニン・アンジオテンシン系の役割(3) 片側腎臓摘出マウスを用いた,近位尿細管におけるアンジオテンシノーゲンの発現調節について

    石上 友章, 梅村 将就, 三樹 祐子, 新城 名保美, 田村 功一, 内野 和顕, 梅村 敏, Gociman B, Rohrwasser A, Lalouel J.M

    血圧   13 ( 3 )   275 - 280   2006.3

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  • 【分子高血圧 最新の進歩】 レニン・アンジオテンシン系の新規発現調節因子および機能制御因子の探索

    田村 功一, 田中 穣, 鶴見 裕子, 酒井 政司, 重永 豊一郎, 小澤 素子, 東 公一, 梅村 将就, 岩坪 耕策, 橋本 達夫, 木原 実, 石上 友章, 岩井 將, Dzau Victor J, 堀内 正嗣, 梅村 敏

    血圧   13 ( 3 )   289 - 293   2006.3

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  • 何が正解? 循環器治療. EBMで検証(20)大動脈弁逆流症の手術時期は,どの時期が最適か?

    石上 友章, 内野 和顕, 梅村 将就

    治療   87 ( 10 )   2889 - 2897   2005.10

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  • Tubular RAS(Renin-Angiotensin System)-Its Implications for Pathogenesis and Development of Essential Hypertension(EH)(Hypertension, Basic 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Ishigami Tomoaki, Umemura Satoshi, Uchino Kazuaki, Umemura Masanari, Toya Yoshiyuki, Tamura Kouichi, Lalouel Jean Marc, Rohrwasser Andreas

    Circulation journal : official journal of the Japanese Circulation Society   69   348 - 348   2005.3

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  • 【分子高血圧 最新の進歩】 本態性高血圧症におけるtubular RAS(rennin angiotensin system)の意義に関する検討

    石上 友章, 梅村 将就, 東 公一, 田村 功一, 内野 和顕, 梅村 敏, Rohrwasser Andreas, Lalouel Jean-Marc

    血圧   12 ( 3 )   313 - 317   2005.3

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  • 何が正解? 循環器治療 EBMで検証 心筋梗塞の二次予防に有効な薬剤は何か?

    田中 穣, 菅野 晃靖, 松本 克己, 内野 和顕, 梅村 将就, 井上 典子, 小川 英幸, 田村 功一, 石上 友章, 石川 利之, 木村 一雄, 梅村 敏

    治療   86 ( 12 )   3248 - 3255   2004.12

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  • 96) 急速に心機能が悪化したミトコンドリア心筋症の一例(第189回日本循環器学会関東甲信越地方会)

    北村 文, 石上 友章, 内野 和顕, 石川 利之, 持田 泰行, 海老名 俊明, 小林 司, 松下 浩之, 松本 克巳, 田中 穣, 川崎 典子, 梅村 将就, 山川 陽平, 邑山 美奈子, 志村 美英, 梅村 敏

    Circulation journal : official journal of the Japanese Circulation Society   68   769 - 769   2004.4

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  • PE-444 Ex vivo E2F Decoy Therapy Preserves Endothelial Healing and Specifically Inhibits Smooth Muscle Cell Proliferation in Vein Grafts(Peripheral Circulation/Vascular Disease 4(H) : PE75)(Poster Session (English))

    Tamura Kouichi, Tanaka Yutaka, Koide Yuichi, Tsurumi Yuko, Sakai Masashi, Umemura Masanari, Hashimoto Tatsuo, Matsushita Kei, Hirawa Nobuhito, Ishigami Tomoaki, Kihara Minoru, Toya Yoshiyuki, Tokita Yasuo, Ehsan Afshin, Umemura Satoshi, Dzau Victor J.

    Circulation journal : official journal of the Japanese Circulation Society   68   470 - 470   2004.3

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  • 2 Molecular genetics of human hypertension-Role of Na handling along the renal tubules, the renin-angiotensin system and ubiquitinligase gene(Symposium 2 (SY2) (H) : Hypertension : From Molecular Mechanisms to Tailored Therapy)(Special Program)

    Ishigami Tomoaki, Lalouel Jean-Marc, Rohrwasser Andreas, Tamura Koichi, Hirawa Nobuhito, Yatsu Keisuke, Umemura Masanari, Uchino Kazuaki, Umemura Satoshi

    Circulation journal : official journal of the Japanese Circulation Society   68   31 - 31   2004.3

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  • 比較的短期間に下肢潰瘍と腎機能低下の増悪がみられ,コレステロール結晶塞栓症が疑われてLDL吸着療法および低用量ステロイド療法を施行して症状の改善が得られた一例

    田村 功一, 梅村 将就, 矢野 英人, 酒井 政司, 伊藤 陽子, 鶴見 裕子, 渋谷 研, 木村 寿宏, 小川 桃子, 横山 恵子, 岡野 泰子, 遠藤 晃彦, 松下 啓, 平和 伸仁, 木原 実, 矢花 眞知子, 戸谷 義幸, 臼井 孝, 常田 康夫, 梅村 敏

    腎炎症例研究   20   29 - 42   2004.2

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  • 急性心筋梗塞発症後,非閉塞性腸管虚血症(Nonocclusive mesenteric ischmia; NOMI)を合併し,救命しえた1例(日本循環器学会関東甲信越地方会第187回学術集会)

    梅村 将就, 臼井 孝, 八鍬 秀之, 澤田 玲民, 萩原 聡子, 佐々木 龍, 川浦 範之, 高見 澤徹, 柏木 政伸, 小林 俊介, 仲野 明, 簾田 康一郎, 森 隆太郎

    Circulation journal : official journal of the Japanese Circulation Society   67   905 - 905   2003.10

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  • ネフローゼ症候群をともなう急性腎不全を呈し老年性ループス腎炎が疑われた一症例

    田村 功一, 高見澤 徹, 梅村 将就, 酒井 政司, 桜井 陽子, 鶴見 裕子, 渋谷 研, 常田 康夫, 梅村 敏

    腎炎症例研究   19   18 - 28   2003.2

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  • 腹膜炎 長期腹膜透析に合併した重症難治性真菌性腹膜炎の治療経過

    田村 功一, 松枝 利恵, 鶴見 裕子, 渋谷 研, 酒井 政司, 桜井 陽子, 梅村 将就, 常田 康夫, 小松 茂治, 河野 敏郎, 佐藤 芳樹, 仲野 明, 小林 俊介

    腎と透析   53 ( 別冊 腹膜透析2002 )   197 - 200   2002.9

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Presentations

  • An alternating magnetic field suppresses tumor growth

    Umemura M, Akimoto T, Islam R, Kishi K, Nagasako A, Nakakaji R, Yamaguchi T, Mizuno Y, Ishikawa S, Yamamoto T, Ishikawa Y

    American Association for Cancer Research Annual meeting (AACR)  2024.4 

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  • 公募シンポジウム1S09e 医・薬・歯・農・食の分野から読み解くカルシウムシグナルの新たな可能性

    梅村将就

    第101回日本生理学会大会 総会・全国学術集会  2024.3 

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  • Development of a Novel Treatment for Glioblastoma Using Alternating Magnetic Fields

    Umemura M., Nagasako A., Kishi K., Yamamoto T.

    The 130th Annual Meeting of the Japanese Association of Anatomi sts (JAA) The 102nd Annual Meeting of the Physiological Society of Japan (PSJ) The 98th Annual Meeting of the Japanese Pharmacological Society (JPS)  2025.3 

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    Event date: 2025.3

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  • PYK2 regulates PD-L1 expression via JAK/STAT signaling in melanoma

    Mizuno Y, Umemura M, Suzuki F, Nakakaji R, Yamaguchi Y, Ishikawa Y

    2023.5 

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    Event date: 2023.10

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  • 医工連携による市販医薬品の薬効成分の磁性化 Invited

    梅村将就

    かながわ医療機器レギュラトリーサイエンスコンソーシアム  2023.9 

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  • EP4 increases the mitochondrial respiration and promotes cell migration in oral cancer.

    Nakakaji R, Umemura M, Osawa K, Ishikawa S, Mitsudok K, Ishikawa Y

    The American Association for Cancer Research Annual Meeting (AACR 2023)  2023.4 

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  • EP4 promoted cell migration via mitochondrial biogenesis in oral cancer cells.

    Ishikawa S, Umemura M, Nakakaji R, Nagasako A, Nagao K, Mizuno Y, Suzuki F, Osawa K, Kioi M, Mitsudo K, Ishikawa Y

    The American Association for Cancer Research Annual Meeting (AACR 2023)  2023.4 

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  • Innovative Technology of Synthesizing Commercially Available Drugs with Intrinsic Magnetic Property Invited

    Masanari Umemura

    Innovation in Science, Engineering and Technology (ICISET 2022)  2022.2 

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    Event date: 2022.2

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  • SY27-1 静水圧や温熱などの外部刺激に対する心臓繊維芽細胞の生理応答

    梅村将就

    第126回日本解剖学会・第98回日本生理学会合同大会 総会・全国学術集会  2021.3 

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  • 心臓線維芽細胞に対するドキソルビシンの線維化促進作用

    梅村将就, 田中 遼, 成川雅俊, 中鍛治里奈, Islam R, 大澤昂平, 引地真由, 石川義弘

    第93回 日本薬理学会年会(WEB開催)  2020.3 

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  • Transcriptional diversity and expression of Nedd4L gene in distal nephrowits implications for sodium sensitive hypertension in rat

    Umemura M, Ishigami T, Araki N, Tamura K, Sakai M, Uchino K, Rohrwasser A, Lalouel JM, Umemura S

    21sth Scientific Meeting of the International-Society-of-Hypertension/5th Asian-Pacific Congress of Hypertension/29th Annual Scientific Meeting of the Japanese-Society-of-Hypertension  2006.10 

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  • The effects of leptin receptor gene polymorphism on visceral fat accumulation and blood pressure

    Ogawa M, Hirawa N, Shiwa T, Endo T, Umemura M, Yatsu K, Saka S, Tamura K, Ishigami T, Yasuda G ,Toya Y, Tabara Y, Miki T, Tokunaga K, Umemura S

    2006.10 

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  • Development of thermochemotherapy using cisplatin and ferucarbotran (Resovist®) in head and neck cancer. International conference

    Sato I, Umemura M, Mitsudo K, Feng X, Nakashima H, Kioi M, Eguchi H, Tohnai I, Ishikawa Y

    The 105 American Association for Cancer Research Annual meeting  2014.4 

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  • Regulations of ENaC Expressions by Nedd4L and tubular Renin-angiotensin Systems Implications for sodium sensitivity and hypertension

    2014.3 

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  • A novel treatment for triple-negative breast cancer using intrinsic magnetized paclitaxel International conference

    UMEMURA Masanari

    The 105 American Association for Cancer Research Annual meeting  2014.4 

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  • 自己有機化合物による磁場誘導ドラッグ・デリバリ―:コンピュータ解析による市販有機化合物の磁性化 Invited

    江口晴樹, 梅村将就, 牧野紋子, 佐藤格, 小田香世子, 大竹誠, 永迫茜, 石川義弘

    日本生体医工学会 分子デリバリー研究会  2014 

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  • Nedd4Lおよび尿細管レニン-アンジオテンシン系を介したENaC発現機能制御

    石上 友章, 梅村 将就, 新城 名保美, 峯岸 慎太郎, 山名 比早子

    日本薬学会 第134年会  2014.3 

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  • Development of a nono-organic particle with ferromagnetism

    Umemura Masanari

    2013.9 

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  • Simultaneous hyperthermo- and chemotherapy with controlled drug delivery with a single drug compound Invited International conference

    UMEMURA Masanari

    BIT’s 11th Annual Congress of International Drug Discovery Science & Technology, Therapy and EXPO  2013.11 

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  • Targeted drug delivery system and magnetic resonance imaging with intrinsic ferromagnetic nano-particle compound. International conference

    Eguchi H, Hirata K, Kurotani R, Fukumura H, Singh J. D, Yamamoto M, Sato I, Umemura M, Yamamoto M, Nagashima Y, Ishikawa Y

    The 104 American Association for Cancer Research Annual meeting  2013.4 

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  • Store-operated Ca²⁺ entry (SOCE) regulates melanoma progression. International conference

    Umemura M, Baljinnyam E, Lorenzo M, Feske S, Lai-Hua Xie, Ishikawa Y, Iwatsubo K

    The 104 American Association for Cancer Research Annual meeting  2013.4 

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  • The function of Store operated Ca2+ entry(SOCE)in melanoma.

    Umemura M, Fujita T, Yokoyama U, Ishikawa Y, Iwatsubo K

    The 90th Annual Meeting of the Physiological Society of Japan  2013.3 

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  • Application of a novel nano-magnetic anti-cancer drug to hyperthermia International conference

    Umemura M, Fukumura H, Sato I, Feng X, Hitoshi Izuka, Eguchi H, Ishikawa Y

    The 104 American Association for Cancer Research Annual meeting  2013.4 

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  • Role of store-operated Ca2+ entry in proliferation and cell cycle in melanoma. International conference

    Umemura M, Balijinnyam E, Lorenzo M, Feske S, Lai-Hua Xie, Iwatsubo K

    The 103 American Association for Cancer Research Annual meeting  2012.4 

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  • Epac1 activates migration of melanoma and endothelial cells via FGF-2 intracellular signaling. International conference

    Balijinnyam E, Umemura M, Lorenzo M, Iwatsubo K

    The 102nd American Association for Cancer Reaserch Annual meeting  2011.4 

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  • Role of Orai1 and STIM1 in store-operated Ca²⁺entry and cell migration in melanoma. International conference

    Umemura M, Balijinnyam E, Lai-Hua Xie, Feske S, Nowycky M, Iwatsubo K

    The 102nd American Association for Cancer Reaserch Annual meeting  2011.4 

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  • A New Programmable Home Blood Pressure Monitoring Device for the Assessment of Nighttime Blood Pressure of Total 40 Normotensive Subjects International conference

    Ishigami T, Ushio H, Minegishi S, Araki, N, Umemura, M, Tamura, K, Uchino, K Umemura, S

    European Society of Hypertension  2010.7 

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  • Gβγ subunit inhibit Epac-induced melanoma cell migration. International conference

    Balijinnyam E, Umemura M, Lai-Hua Xie, Nowycky M, Iwatsubo K

    The 102nd American Association for Cancer Reaserch Annual meeting  2011.4 

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  • Identification of binding proteins for human Nedd4L C2 domain. International conference

    Araki N, Ishigami T, Umemura M, Tamura K, Toya Y, Uchino K, Umemura S

    The 22nd Scientific Meeting of the international Society of hypertension  2008.6 

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  • Angiotensin II Induced Scn5a-Nedd4l transcriptional activation with mineral corticoid receptor transactivation in cardiomyocytes International conference

    Minegishi S, Ishigami T, Ushio H, Araki N, Umemura M, Toya Y, Uchino K, Umemura S

    European Society of Hypertension  2010.7 

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  • Methotrexate derivative with intrinsic magnetism International conference

    Umemura M, Katsumata M, Sato I, Nagasako A, Aoyama H, Makino A, Ohatake M, Oda K, Eguchi H, Ishikawa Y

    The 106 American Association for Cancer Research Annual meeting  2015.4 

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  • Prostaglandin E2 receptor EP4 regulates fibrotic changes via intracellular calcium in cardiac fibroblast cells International conference

    Umemura M, Osawa K, Tanaka R, Hikichi M, Nakakaji R, Ishikawa Y

    American Heart Association (AHA), Scientific Sessions  2019.11 

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  • New Translational Insights on Cardiopulmonary Remodeling International conference

    Umemura M, Narikawa M, Tanaka R, IshikawaY

    9th FAOPS (Federation of the Asian and Oceanian Physiological Societies)  2019.3 

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    Language:English   Presentation type:Symposium, workshop panel (nominated)  

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  • New technology of Synthesizing Commercial Available Drugs with Intrinsic Magnetism. Invited International conference

    Umemura Masanari

    BIT’s 17th Annual Congress of International Drug Discovery Science & Technology  2019.7 

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  • Doxorubicin directly induced fibrotic change of cardiac fibroblasts and matrix metalloproteinase-1 International conference

    Narikawa M, Umemura M, Tanaka R, Ishigami T, Tamura K, Ishikawa

    The American College of Cardiology (ACC) 2019  2019.3 

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  • Epac activation inhibits IL-6-induced cardiac myocyte dysfunction International conference

    Jin H, Fujita T, jin M, Kuratani R, Hidaka Y, Cai W, Suita K, Prajapati R, Ligang C, Ohnuki Y, Mototani Y, Umemura M, Yokohyama U, Sato M, Okumura S, Ishikawa Y

    9th FAOPS (Federation of the Asian and Oceanian Physiological Societies)  2019.3 

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  • Development of new compounds as a research tool to investigate physiological events

    Umemura Masanari

    2018.3 

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  • Hydrostatic pressurization suppressed fibrotic change via Akt/GSK-3 signaling in human cardiac fibroblasts International conference

    Umemura M, Tanaka R, Narikawa M, Ishikawa Y

    The American College of Cardiology (ACC) 2019: 68th Annual Scientific Session & Expo  2019.3 

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  • The function of Transient Receptor Potential Canonical 3 (TRPC3) Channel in cell proliferation.

    Umemura Masanari

    The 94th Annual Meeting of the Physiological Society of Japan  2017.3 

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  • Novel thermo-chemotherapy for oral cancer using a new magnetic anti-cancer drug. International conference

    Sato I, Umemura M, Mitsudo K, Nakashima H, Kioi M, Eguchi H, Ohtake M, Kayoko Oda, Nakakaji R, Tohnai I, Ishikawa Y

    The 18th ECCO European Cancer Organisation- 40th ESMO European Cancer Congress Scientific Committee  2015.9 

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  • Anticancer Nanomagnet-loaded Smart Nano-Ensembles for Magneto-Drug Delivery, MRI, and Hyperthermal Cancer Targeting International conference

    Kim JH, Eguchi H, Umemura M, Ishikawa Y

    Asia Nano  2016.10 

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  • 市販医薬品の薬効成分の磁性化にむけて Invited

    梅村 将就

    遺伝子・デリバリー研究会  2015.5 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • Simultaneous hyperthermic-chemotherapy using a single anti-cancer compound with intrinsic magnetism in glioblastoma animal model. International conference

    Ohtake M, Umemura M, Sato I, Akimoto T, Nagasako A, Eguchi H, Kawahara N, Ishikawa Y

    The 18th ECCO European Cancer Organisation- 40th ESMO European Cancer Congress Scientific Committee  2015.9 

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  • Simultaneous hyperthermic-chemotherapy for glioblastoma using a single anti-cancer compound with magnetism. International conference

    Ohtake M, Umemura M, Sato I, Oda K, Nagasako A, Makino A, Aoyama H, Katsumata M, Eguchi H, Kawahara N, Ishikawa Y

    The 106 American Association for Cancer Research Annual meeting  2015.4 

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  • Transient receptor potential cation channel 3 (TRPC3) regulates tumor proliferation and migration of BRAF wild type human malignant melanoma. International conference

    Oda K, Umemura M, Baljinntam E, Yamaguchi Y, Aihara M, Iwatsubo K, Ishikawa Y

    The 106 American Association for Cancer Research Annual meeting  2015.4 

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  • Development of combination therapy with cisplatin and hyperthermia generated with ferucarbotran (Resovist) in an alternating magnetic field for oral cancer. International conference

    Sato I, Mitsudo K, Umemura M, Nakashima H, Kioi M, Eguchi H, Ishikawa Y, Tohnai I

    The 6th Asian Congress of Hyperthermic Oncology (ACHO)  2014.9 

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Industrial property rights

  • がん治療システム

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    Applicant:株式会社リコー

    Application no:特願2024-184806  Date applied:2024.10

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  • がん治療装置と遮蔽部材のセット、遮蔽部材、及びがん治療装置

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    Applicant:株式会社リコー

    Application no:特願2024-180246  Date applied:2024.10

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Awards

  • 横浜市立大学医学会 医学会賞

    2021.5   横浜市立大学医学会  

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  • ベストティーチャー賞(基礎医学部門)団体賞

    2025.5   横浜市立大学医学部医学科  

    循環制御医学教室

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  • ベストティーチャー賞(基礎医学部門)団体賞

    2024.5   横浜市立大学医学部医学科  

    循環制御医学教室

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  • ベストティーチャー個人賞<殿堂入り>

    2023.5   横浜市立大学医学部医学科  

    梅村将就

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  • ベストティーチャー賞(基礎医学部門)団体賞

    2023.5   横浜市立大学医学部医学科  

    循環制御医学教室

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  • ベストティーチャー賞 (2年の部) 個人賞

    2022.5   横浜市立大学 医学部医学科  

    梅村将就

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  • ベストティーチャー賞 (基礎医学部門) 団体賞

    2022.5   横浜市立大学 医学部医学科  

    循環制御医学教室

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  • ベストティーチャー賞 (基礎医学部門) 団体賞

    2021.4   横浜市立大学医学部医学科  

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  • ベストティーチャー賞 (2年の部)

    2020.5   横浜市立大学医学部医学科   個人賞

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  • 学長表彰 奨励賞

    2020.3   横浜市立大学  

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  • ベストティーチャー賞 (2年の部)

    2019.6   横浜市立大学医学部医学科   個人賞

    梅村 将就

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  • ベストティーチャー賞 (3年の部)

    2019.6   横浜市立大学医学部医学科   個人賞

    梅村 将就

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  • 学長表彰 奨励賞

    2019.3   横浜市立大学  

    梅村 将就

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  • ベストティーチャー賞 (3年の部)

    2018.7   横浜市立大学医学部医学科   個人賞

    梅村 将就

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  • ベストティーチャー賞 (2年の部)

    2018.7   横浜市立大学医学部医学科   個人賞

    梅村 将就

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  • ベストティーチャー賞 (2年生の部)

    2014   横浜市立大学医学部医学科   個人賞

    梅村 将就

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Research Projects

  • 交流磁場を用いた脳腫瘍治療装置の開発

    2025.1 - 2025.9

    Greater Tokyo Innovation Ecosystem  GTIE GAP ファンドプログラム 2024 

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    Authorship:Principal investigator 

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  • 交流磁場の持つ抗腫瘍効果を応用したがん治療装置の開発

    2024.8 - 2025.3

    国立研究開発法人日本医療研究開発機構 (AMED)  令和 6 年度「橋渡し研究プログラム」研究  シーズ preF 調整費

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\18533000

    調整費

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  • 交流磁場の持つ抗腫瘍効果を応用したがん治療装置の開発

    Grant number:B466TR  2023.5 - 2025.3

    国立研究開発法人日本医療研究開発機構 (AMED)  令和 5 年度「橋渡し研究プログラム」研究  シーズ preF

    梅村将就

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\26000000 ( Direct Cost: \20000000 、 Indirect Cost:\60000000 )

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  • 交流磁場の持つ抗腫瘍効果のメカニズム解析とがん治療への応用

    2021.4 - 2028.3

    国立研究開発法人科学技術振興機構(JST)  創発的研究支援事業 

    梅村将就

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\50000000

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  • 交流磁場を用いた神経膠芽腫の新規治療法の開発

    2020.10 - 2021.3

    日本医療開発機構 (AMED)  医療分野研究成果展開事業 先端計測分析技術・機器開発プログラム (R2 追加支援) 

    梅村将就

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\50000000

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  • 神経膠芽腫に対する交流磁場を用いた医療装置の開発

    2019.12 - 2020.3

    日本医療開発機構 (AMED)  革新的医療技術創出拠点プロジェクト (橋渡し研究戦略的推進プログラム:シーズA)追加支援 

    梅村 将就

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1500000

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  • 交流磁場を用いた神経膠芽腫の新規治療法の開発

    2019.8 - 2022.3

    日本医療開発機構 (AMED)  医療分野研究成果展開事業 先端計測分析技術・機器開発プログラム 

    梅村 将就

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\54600000

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  • 神経膠芽腫に対する交流磁場を用いた医療装置の開発

    2018.4 - 2020.3

    日本医療研究開発機構 (AMED)  革新的医療技術創出拠点プロジェクト(橋渡し研究戦略的推進プログラム:シーズA)  研究助成

    梅村 将就

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\6500000

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  • 交流磁場で治す”脳腫瘍治療装置の開発

    2025.10 - 2028.3

    Greater Tokyo Innovation Ecosystem(GTIE)  GTIE GAPファンドプログラム エクスプロール第3回(2025年2期) 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\60000000

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  • 非虚血性心不全症例の、冠微小循環障害の合併頻度およびその機序を解明する研究

    Grant number:23K07483  2023.4 - 2027.3

    日本学術振興財団  科学研究費助成事業  基盤研究(C)

    日比潔, 梅村将就 他

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    Authorship:Coinvestigator(s) 

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

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  • 心臓線維芽細胞におけるドキソルビシンの心毒性メカニズムの解析

    Grant number:22K06928  2022.4 - 2025.3

    日本学術振興財団  科学研究費助成事業  基盤研究(C)

    梅村将就, 中鍛治里奈, 永迫茜

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

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  • Molecular mechanism of magnetic sensor in pancreatic cancer cells

    Grant number:22H03926  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\700000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

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  • ⼝腔癌における交流磁場が持つ遊⾛能抑制効果の分⼦⽣物学的研究

    Grant number:22K10154  2022.4 - 2025.3

    日本学術振興財団  科学研究費助成事業  基盤研究(C)

    光藤健司, 梅村将就, 中鍛治里奈

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    Authorship:Coinvestigator(s) 

    Grant amount:\200000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

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  • 交流磁場を用いた神経膠芽腫の新規治療法の開発

    2021.8

    日本医療研究開発機構 (AMED)  医療分野研究成果展開事業先端計測分析技術・機器開発プログラム (R3 調整費) 

    梅村将就

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    Authorship:Principal investigator 

    Grant amount:\72000000

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  • SK202001

    Grant number:SK202001  2021.4 - 2024.3

    公立大学法人 横浜市立大学  学長裁量事業 第5期戦略的研究推進事業「研究開発プロジェクト」 

    石川義弘, 梅村将就

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    Authorship:Coinvestigator(s) 

    Grant amount:\2000000

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  • 交流磁場を用いた膵癌治療法の実用化

    2020.4 - 2021.3

    横浜市  (追加支援) ライフイノベーション分野産学連携等推進事業補助金「LIP.横浜推進プロジェクト」  研究助成

    梅村将就

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    Authorship:Principal investigator 

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  • 間接経費

    2020

    横浜市立大学  間接経費(福浦キャンパス) 

    梅村将就

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    Authorship:Principal investigator 

    Grant amount:\5049000 ( Indirect Cost:\5049000 )

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  • TGF-βの新規制御分子プロスタグランディン受容体EP4による心臓線維化抑制

    2019.4 - 2022.3

    日本学術振興財団 科学研究費助成事業  基盤C (新規) 

    梅村 将就

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3380000

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  • 口腔癌におけるCaveolin-1 とIL-6の役割

    2019.4 - 2022.3

    日本学術振興財団 科学研究費助成事業  基盤C (新規) 

    光藤健司, 梅村 将就

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    Authorship:Principal investigator  Grant type:Competitive

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  • 医工連携から生まれた市販医薬品の磁性化技術の開発

    2018.12

    上原記念生命科学財団  研究助成金 

    梅村 将就

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\5000000

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  • 循環制御制御におけるホメオタシスの破綻予測

    2018.4

    Japan Society for the Promotion of Science  基盤研究(C)分担研究員 

    Umemura Masanari

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    Authorship:Principal investigator  Grant type:Competitive

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  • 交流磁場を用いた膵癌治療法の実用化

    2017.4 - 2019.3

    Umemura Masanari

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\7000000

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  • 自律神経による心機能制御

    2016.4 - 2019.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    石川義弘, 梅村将就

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    Authorship:Coinvestigator(s) 

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  • 産学連携から生まれた磁性分子標的薬を用いた新しい悪性軟部腫瘍に対する治療法の開発

    2016.4 - 2017.3

    第28回SGH(旧佐川)がん研究助成金 

    Umemura Masanari

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  • 産学連携から生まれた市販医薬品磁性化技術を臨床応用するための研究

    2016

    臨床薬理研究振興財団 

    Umemura Masanari

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    Authorship:Principal investigator  Grant type:Competitive

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  • 骨肉腫に対する磁性メトトレキセートを用いた新しい治療法の開発

    2015.4 - 2016.3

    武田振興財団  医学系研究奨励 (癌領域・基礎) 

    梅村 将就

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    Authorship:Principal investigator  Grant type:Competitive

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  • 汎用性抗がん剤の磁性化に関する研究

    2015

    国立研究開発法人 日本医療研究開発機構  次世代がん研究シーズ戦略的育成プログラム (分担研究者) 

    石川 義弘

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    Grant type:Competitive

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  • 画期的技術を用いて合成した自己磁性タキソールを用いた新しい乳がん治療

    2014.4 - 2017.3

    日本学術振興財団 科学研究費助成事業  若手研究B 

    Umemura Masanari

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    Authorship:Principal investigator  Grant type:Competitive

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  • 自律神経による心制御のメカニズム

    2014.3 - 2015.4

    日本学術振興会  科学研究費助成事業 基盤研究(B)(分担研究者) 

    石川義弘

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    Grant type:Competitive

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  • グリオブラストーマに対する,抗がん活性を併せ持つ磁性体有機化合物を用いた化学・温熱同時単剤療法

    2013

    公益財団法人横浜学術教育振興財団  研究助成  研究助成

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    Authorship:Principal investigator 

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  • 医工連携から生まれた磁性体有機化合物を利用した悪性中皮腫治療への新しいアプローチ

    2013

    公益財団法人持田記念医学薬学振興財団  研究助成 

    梅村 将就

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    Authorship:Principal investigator  Grant type:Competitive

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  • 奨励賞

    2011

    神奈川難病研究財団  神奈川難病研究財団  研究助成

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    Authorship:Principal investigator 

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  • アデニル酸シクラーゼを標的とした心不全メカニズムの解明及び新規心不全治療薬の開発

    2010

    第23回 日本心臓財団・バイエル薬品  海外留学助成 

    梅村 将就

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    Authorship:Principal investigator  Grant type:Competitive

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  • 研究助成金

    2006

    横浜総合医学振興財団  研究助成金 

    梅村 将就

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    Authorship:Principal investigator  Grant type:Competitive

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  • 21st Century COE Program

    2005

    Yokohama City University  21st Century COE Program 

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    Authorship:Principal investigator 

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  • 21st Century COE Program

    2004

    Yokohama City University  21st Century COE Program 

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    Authorship:Principal investigator 

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Other

  • JST理事長記者説明会での研究紹介

    2021.7

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    https://www.jst.go.jp/all/about/president/pressconference/index.html

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  • エルゼビア eReview基礎医学科目・臨床医学科目

    2019.9

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    E-ラーニング コンテンツ監修・アドバイザー

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  • オープンドクターズ 医療情報サイト

    2019.4 - 2021.3

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    コンテンツ監修・コラム執筆

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  • 日本循環器学会 ACLS講習会 インストラクター認定

    2006.1

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Teaching Experience

  • 臨床医学概論

    2024.11 Institution:早稲田大学 先進理工学部

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  • 循環生理学

    2024.6 Institution:横浜市立大学大学院医学研究科

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  • 大学院特別講義

    2023.9 Institution:日本大学生物資源科学

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  • 医科学特論

    2022.5 Institution:横浜市立大学 大学院 生命医科学研究科

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  • 臨床概論・疾病病態学

    2020.12 Institution:横浜市立大学 国際総合生命医科学3年・理学部2年

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  • 人体の解剖生理学 循環器系(心臓と脈管系の構造と生理)

    2020.5 - 2022.5 Institution:横浜市立大学横浜市立大学 理学部

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  • 生理学

    2020.4 Institution:愛知医科大学医学部

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  • 発生・再生医学

    2019.5 - 2022.5 Institution:横浜市立大学 生命医科学

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  • 医学研究の進め方 (大学院講義) 医学英語

    2017.6 Institution:横浜市立大学大学院医学研究科 循環制御医学

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  • 循環器内科

    2017 Institution:横浜市立大学医学部医学科 循環器内科

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  • 心臓

    2014 - 2016 Institution:横浜労災看護専門学校

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  • 病態代謝生理学

    2013 Institution:横浜市立大学医学部医学科 循環制御医学

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  • 生理学 (循環器・呼吸器・腎臓・血液)

    2013 Institution:横浜市立大学医学部医学科 循環制御医学

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  • 生理学実習

    2012.11 Institution:横浜市立大学横浜市立大学 医学部医学科 循環制御医学

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Social Activities

  • 「医学を身近に感じよう!」~ 心臓の秘密に迫る~

    Role(s): Lecturer

    横浜市立横浜サイエンスフロンティア高校  出張模擬授業  2024.7

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    Type:Visiting lecture

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  • Online Open Campus 2023 横浜市大 模擬授業「心臓の働きと心臓病」

    Role(s): Lecturer

    横浜市立大学医学部医学科  2023.8

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    Type:Visiting lecture

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  • 横浜市立大学医学部メディカルフェスティバル 「医学を志す」中・高校生対象

    Role(s): Commentator, Lecturer, Advisor

    AVENUE EDUCATION  2022.11

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    Type:Lecture

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  • 健康診断を10倍楽しく受ける方法~優しく生理学を学んで健康診断に活用しよう!~

    Role(s): Lecturer

    横浜市立大学 Medical Festival  2019.11

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    Type:Lecture

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  • 夏のオープンキャンパス 医学科

    Role(s): Lecturer, Advisor, Planner, Demonstrator

    横浜市立大学医学部医学科  シミュレーションセンター体験  2019.8

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    Type:Seminar, workshop

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  • 夏のオープンキャンパス 医学科

    Role(s): Lecturer, Advisor, Organizing member, Demonstrator

    横浜市立大学医学部医学科  シミュレーションセンター体験  2018.8

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    Type:Seminar, workshop

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  • 医療ドラマ・マンガを100倍楽しく見る方法

    Role(s): Lecturer

    横浜市立大学  横浜市立大学医学祭  2016.11

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    Type:Lecture

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  • 夏のオープンキャンパス 医学科

    Role(s): Lecturer, Advisor, Organizing member, Demonstrator

    横浜市立大学 医学部 医学科  シミュレーションセンター体験  2016.8

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    Type:Seminar, workshop

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Media Coverage

  • 大学案内から連携される「ヨコ知リ!」の研究者インタビュー(誌面及びWeb)

    横浜市立大学  大学案内  横浜市立大学 大学案内 誌面及びWeb  2022.6

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  • がん治療の新技術 Newspaper, magazine

    産業春秋  日刊工業新聞  2021.8

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    Author:Other 

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  • がん治療の新技術 Internet

    産業春秋  日刊工業新聞  https://www.nikkan.co.jp/articles/view/00607670  2021.8

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    Author:Other 

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  • ドラマ・マンガで医療学ぶ Newspaper, magazine

    毎日新聞  2016.11

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Academic Activities

  • 第130 回日本解剖学会総会・全国学術集会・ 第102 回日本生理学会大会・第98回日本薬理学会年会 合同大会 一般口演: 体液, 循環, 免疫反応

    Role(s): Panel moderator, session chair, etc.

    日本解剖学会・日本生理学会・日本薬理学会  2025.3

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    Type:Competition, symposium, etc. 

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  • 日本医学教育学会 医学教育専門家

    日本医学教育学会  2025.1 - 2030.12

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    Type:Academic society, research group, etc. 

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  • 日本心臓病学会 代議員

    日本心臓病学会  2024.11 - 2026.10

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  • 日本生理学会 卓越生理学エデュケーター

    2024.1

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    Type:Academic society, research group, etc. 

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  • 国際生理科学連合 (IUPS) 国際メンタリングプログラムに参画するメンターに選出

    国際生理科学連合 (IUPS) 及び日本生理学会  2023.11

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    Type:Academic society, research group, etc. 

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  • 日本循環器学会 5分でわかる循環器Best Teacher Series 5分でわかる心臓電気軸とは何か?

    日本循環器学会  2023.11

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  • 日本心臓病学会 心臓病上級臨床医 (Fellow of the Japanese College of Cardiology: FJCC会員)

    Role(s): Planning, management, etc.

    日本心臓病学会  2023.4

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