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写真a

 
Yuichi Ishikawa
 
Organization
Graduate School of Nanobioscience Department of Materials System Science Associate Professor
School of Science Department of Science
Title
Associate Professor
Profile
天然物化学、有機合成化学を基盤として次の2つを主眼に研究を行ってきた。
1、特異な生物活性・構造を有する天然有機化合物の合成
Bryostatin類は、顕著な抗腫瘍活性を有するポリエーテルマクロライドであり、その活性と特異な構造から多くの注目を集めている。それらbryostatin類の中でも最も複雑な構造を有するbryostatin 3の合成を行い、初の全合成を達成することができた(Angew. Chem. Int. Ed. 2000, 39, 2290)。また、同様に強力な抗腫瘍活性をもつマクロライドであるamphidinolide類についても合成研究を行った。その結果、amphidinolide B、G、Hについて、全合成を達成した(Angew. Chem. Int. Ed. 2012, 51, 9877)。
2、合成的手法を用いた新規人工生物活性物質の創製
NF-κB阻害剤として見いだされた9-methylstreptimidoneは、その活性発現機構について未解明のままである。しかしながら、さらなる活性試験に供するためには、より多くの化合物が必要であることから、サンプルの大量供給のための構造の簡略化を目的として各種誘導体を合成し、その活性評価を行った。その結果、新規誘導体DTCM-glutarimideが天然物に匹敵する抗炎症作用を有することを見出した(Bioorg. Med. Chem. Lett. 2009, 19, 1726)。
External link

Degree

  • Ph. D. ( Keio University )

Research Interests

  • Biological Organic Chemistry Natural Organic compounds

  • Synthetic Organic Chemistry

  • Organic chemistry

  • Natural products chemistry

Research Areas

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

Education

  • Keio University

    2001.4 - 2004.3

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  • Keio University   Graduate School, Division of Science and Engineering

    - 2004

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  • Keio University

    1999.4 - 2001.3

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  • Keio University   Graduate School, Division of Science and Engineering

    - 2001

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  • Keio University   Faculty of Science and Technology   Department of Chemistry

    1995.4 - 1999.3

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  • Keio University   Faculty of Science and Engineering

    - 1999

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Research History

  • 横浜市立大学 理学部 理学科 生命ナノシステム科学研究科 物質システム科学専攻   准教授

    2019.4

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  • 横浜市立大学 学術院 自然科学系列   国際総合科学部 物質科学コース   准教授

    2014.4 - 2019.3

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  • 横浜市立大学 学術院 自然科学系列   国際総合科学部 物質科学コース   助教

    2011.4 - 2014.3

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  • Keio University   Faculty of Science and Technology, Department of Chemistry   Assistant Professor

    2007.4 - 2011.3

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  • ライプティヒ大学(ドイツ)   アレクサンダー・フォン・フンボルト研究員

    2005.6 - 2007.3

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  • Keio University   Faculty of Science and Technology, Department of Chemistry

    2005.4 - 2005.5

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  • Keio University   Faculty of Science and Technology, Department of Chemistry

    2002.4 - 2005.3

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  • Yokohama City University International College of Arts and Sciences, Department of Materials Science Graduate School of Nanobioscience Department of Materials System Science   Associate Professor

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  • Keio University Faculty of Science and Technology, Department of Chemistry, Faculty of Science and Technology Faculty of Science and Technology, Department of Chemistry   Instructor

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  • Yokohama City University International College of Arts and Sciences Materials Science Graduate School of Nanobioscience Department of Materials System Science   Associate Professor

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Professional Memberships

Papers

  • An efficient enantiospecific synthesis of neuroactive glutamate analogs Reviewed

    Tsukamoto Shuntaro, Itagaki Hiyori, Morokuma Kenji, Miyako Kei, Ishikawa Yuichi, Sakai Ryuichi, Oikawa Masato

    Heterocycles   101 ( 1 )   91 - 98   2020

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    Herein we report improved enantiospecific synthesis and some structure-activity relationships of our heterotricyclic artificial glutamate analogs bearing seven-membered ring for the C-ring. Starting from readily available oxanorbornene rac-3, optically pure (2R)-TKM-107, (2R)-IKM-154, and the antipodes were synthesized in total nine steps for each. Mice in vivo assay indicated that only the (2R)-enantiomer was active in both cases. Behaviors phenotypes observed in the mice assay suggested that these compounds are similar in mode of action to that of IKM-159 but with discrete potency.

    DOI: 10.3987/COM-19-S(F)2

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  • Photoremovable NPEC group compatible with Ns protecting group in polyamine synthesis Reviewed

    MIYAHARA Masayoshi, SHIOZAKI Hiroki, TUKADA Hideyuki, ISHIKAWA Yuichi, OIKAWA Masato

    Tetrahedron Letters   59   4259 - 4262   2018.10

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  • Studies on Aculeines: Synthetic Strategy to the Fully Protected Protoaculeine B, the N‐Terminal Amino Acid of Aculeine B Reviewed

    SHIOZAKI Hiroki, Miyahara Masayoshi, OTSUKA Kazunori, MIYAKO Kei, HONDA Akito, TAKASAKI Yuichi, TAKAMIZAWA Satoshi, TSUKADA Hideyuki, ISHIKAWA Yuichi, SAKAI Ryuichi, OIKAWA Masato

    Org. Lett.   20   3403 - 3407   2018.5

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  • Prins reaction using trioxane for trisubstituted, cis-fused hexahydro-2h-furo [3,2-b] pyran derivative Reviewed

    Oriel Hlokoane, Hiyori Itagaki, Manami Chiba, Taiki Noda, Yuichi Takasaki, Kei Miyako, Ryuichi Sakai, Yuichi Ishikawa, Masato Oikawa

    Heterocycles   96 ( 3 )   453 - 460   2018

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Institute of Heterocyclic Chemistry  

    DOI: 10.3987/COM-17-13776

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  • A monocyclic neodysiherbaine analog: Synthesis and evaluation Reviewed

    Koichi Fukushima, Yuichi Ishikawa, Ryuichi Sakai, Masato Oikawa

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   26 ( 21 )   5164 - 5167   2016.11

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    DOI: 10.1016/j.bmcl.2016.09.074

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  • Synthetic study of strongylophorines: stereoselective construction of the characteristic lactone bridge Reviewed

    Yuya Oikawa, Daiki Uchiyama, Takuya Shirasawa, Masato Oikawa, Yuichi Ishikawa

    TETRAHEDRON LETTERS   57 ( 35 )   3949 - 3951   2016.8

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    DOI: 10.1016/j.tetlet.2016.07.067

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  • Three-Component, Diastereoselective Prins-Ritter Reaction for cis-Fused 4-Amidotetrahydropyrans toward a Precursor for Possible Neuronal Receptor Ligands Reviewed

    Manami Chiba, Yuichi Ishikawa, Ryuichi Sakai, Masato Oikawa

    ACS COMBINATORIAL SCIENCE   18 ( 7 )   399 - 404   2016.7

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    DOI: 10.1021/acscombsci.6b00046

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  • Studies directed toward synthesis of taepeenin D: construction of the C4 stereogenic center and the CD benzofuran rings Reviewed

    Yuichiro Nakazawa, Meri Nagatomo, Tsuyoshi Oikawa, Masato Oikawa, Yuichi Ishikawa

    TETRAHEDRON LETTERS   57 ( 24 )   2628 - 2630   2016.6

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    DOI: 10.1016/j.tetlet.2016.05.005

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  • Asymmetric Organocatalytic Cyclopropanation on Chiral Menthyl Acrylate for the Synthesis of (-)-trans-2-Aminomethylcyclopropanecarboxylic Acid [(-)-TAMP] Reviewed

    Yuka Sugeno, Yuichi Ishikawa, Masato Oikawa

    SYNLETT   25 ( 7 )   987 - 990   2014.4

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    DOI: 10.1055/s-0033-1340953

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  • First enantioselective total synthesis of (-)-dysibetaine CPa and absolute configurations of natural product Reviewed

    Michihiro Sakai, Yuichi Ishikawa, Satoshi Takamizawa, Masato Oikawa

    TETRAHEDRON LETTERS   54 ( 44 )   5911 - 5912   2013.10

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    DOI: 10.1016/j.tetlet.2013.08.113

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  • A Synthesis of (-)-cis-2-Aminomethylcyclopropanecarboxylic Acid [(-)-CAMP] Reviewed

    Masato Oikawa, Yuka Sugeno, Yuichi Ishikawa, Hideyuki Tukada

    SYNLETT   24 ( 7 )   886 - 888   2013.4

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    DOI: 10.1055/s-0032-1317802

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  • Studies on an (S)-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid (AMPA) Receptor Antagonist IKM-159: Asymmetric Synthesis, Neuroactivity, and Structural Characterization Reviewed

    Lina Juknaite, Yutaro Sugamata, Kazuya Tokiwa, Yuichi Ishikawa, Satoshi Takamizawa, Andrew Eng, Ryuichi Sakai, Darryl S. Pickering, Karla Frydenvang, Geoffrey T. Swanson, Jette S. Kastrup, Masato Oikawa

    JOURNAL OF MEDICINAL CHEMISTRY   56 ( 6 )   2283 - 2293   2013.3

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    DOI: 10.1021/jm301590z

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  • 1-Hydroxy-2-methyl-2-propyl Isocyanide (HMPI) as a New Convertible Isocyanide for the Ugi Four-Component-Coupling Reaction Reviewed

    Oikawa Masato, Sugamata Yutaro, Chiba Manami, Fukushima Koichi, Ishikawa Yuichi

    Synlett   24 ( 15 )   2014 - 2018   2013

  • Biology- and diversity-oriented domino reactions for synthesis of AMPA receptor antagonist IKM-159 and analogs Reviewed

    Oikawa M, Kasori Y, Katayama L, Murakami E, Oikawa Y, Ishikawa Y

    Synthesis   45   3106 - 3117   2013

  • Total Synthesis of (+/-)-Dysibetaine CPa and Analogs Reviewed

    Masato Oikawa, Shota Sasaki, Michihiro Sakai, Yuichi Ishikawa, Ryuichi Sakai

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   2012 ( 29 )   5789 - 5802   2012.10

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    DOI: 10.1002/ejoc.201200730

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  • Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide Reviewed

    Eisuke Ota, Masatoshi Takeiri, Miyuki Tachibana, Yuichi Ishikawa, Kazuo Umezawa, Shigeru Nishiyama

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   22 ( 1 )   164 - 167   2012.1

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    DOI: 10.1016/j.bmcl.2011.11.045

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  • Total Syntheses of Amphidinolides B, G, and H Reviewed

    Akihiro Hara, Ryo Morimoto, Yuki Iwasaki, Tsuyoshi Saitoh, Yuichi Ishikawa, Shigeru Nishiyama

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   51 ( 39 )   9877 - 9880   2012

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    DOI: 10.1002/anie.201204992

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  • Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-kappa B components Reviewed

    Tsuyoshi Saitoh, Masatoshi Takeiri, Yuko Gotoh, Yuichi Ishikawa, Kazuo Umezawa, Shigeru Nishiyama

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   21 ( 21 )   6293 - 6296   2011.11

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    DOI: 10.1016/j.bmcl.2011.08.122

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  • Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone Reviewed

    Masatoshi Takeiri, Miyuki Tachibana, Ayumi Kaneda, Ayumi Ito, Yuichi Ishikawa, Shigeru Nishiyama, Ryoichi Goto, Kenichiro Yamashita, Susumu Shibasaki, Gentaro Hirokata, Michitaka Ozaki, Satoru Todo, Kazuo Umezawa

    INFLAMMATION RESEARCH   60 ( 9 )   879 - 888   2011.9

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    DOI: 10.1007/s00011-011-0348-z

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  • Synthesis of the C7-26 Fragment of Amphidinolides G and H Reviewed

    Akihiro Hara, Ryo Morimoto, Yuichi Ishikawa, Shigeru Nishiyama

    ORGANIC LETTERS   13 ( 15 )   4036 - 4039   2011.8

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    DOI: 10.1021/ol201547q

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  • Synthesis of Key Fragments of Amphidinolide Q - A Cytotoxic 12-membered Macrolide Reviewed

    Kohei Kawa, Akihiro Hara, Yuichi Ishikawa, Shigeru Nishiyama

    MOLECULES   16 ( 7 )   5422 - 5436   2011.7

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    DOI: 10.3390/molecules16075422

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  • A synthetic approach to carbazoles using electrochemically generated hypervalent iodine oxidant Reviewed

    Daichi Kajiyama, Keisuke Inoue, Yuichi Ishikawa, Shigeru Nishiyama

    TETRAHEDRON   66 ( 52 )   9779 - 9784   2010.12

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    DOI: 10.1016/j.tet.2010.11.015

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  • A new NF-kappa B inhibitor based on the amino-epoxyquinol core of DHMEQ Reviewed

    Tsuyoshi Saitoh, Chika Shimada, Masatoshi Takeiri, Mitsuhiro Shiino, Shigeru Ohba, Rika Obata, Yuichi Ishikawa, Kazuo Umezawa, Shigeru Nishiyama

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   20 ( 19 )   5638 - 5642   2010.10

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    DOI: 10.1016/j.bmcl.2010.08.036

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  • Electrochemical construction of the diaryl ethers: a synthetic approach to o-methylthalibrine Reviewed

    Yu Naito, Takamasa Tanabe, Yuki Kawabata, Yuichi Ishikawa, Shigeru Nishiyama

    TETRAHEDRON LETTERS   51 ( 36 )   4776 - 4778   2010.9

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    DOI: 10.1016/j.tetlet.2010.07.037

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  • A Novel Approach to Indoloditerpenes by Nazarov Photocyclization: Synthesis and Biological Investigations of Terpendole E Analogues Reviewed

    Fatima Churruca, Manolis Fousteris, Yuichi Ishikawa, Margarete von Wantoch Rekowski, Candide Hounsou, Thomas Surrey, Athanassios Giannis

    ORGANIC LETTERS   12 ( 9 )   2096 - 2099   2010.5

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    DOI: 10.1021/ol100579w

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  • Synthesis of Tetrahydropyrroloiminoquinone Alkaloids Based on Electrochemically Generated Hypervalent Iodine Oxidative Cyclization Reviewed

    Keisuke Inoue, Yuichi Ishikawa, Shigeru Nishiyama

    ORGANIC LETTERS   12 ( 3 )   436 - 439   2010.2

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    DOI: 10.1021/ol902566p

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  • Efficient synthesis of (+/-)-parasitenone, a novel inhibitor of NF-kappa B Reviewed

    Tsuyoshi Saitoh, Eriko Suzuki, Arisa Takasugi, Rika Obata, Yuichi Ishikawa, Kazuo Umezawa, Shigeru Nishiyama

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   19 ( 18 )   5383 - 5386   2009.9

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    DOI: 10.1016/j.bmcl.2009.07.120

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  • A synthetic study on gymnastatins F and Q: the tandem Michael and aldol reaction approach Reviewed

    Kyoko Murayama, Takamasa Tanabe, Yuichi Ishikawa, Kensuke Nakamura, Shigeru Nishiyama

    TETRAHEDRON LETTERS   50 ( 26 )   3191 - 3194   2009.7

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    DOI: 10.1016/j.tetlet.2009.01.156

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  • Total synthesis of (+/-)-megistophylline I Reviewed

    Yuko Nishihama, Yuichi Ishikawa, Shigeru Nishiyama

    TETRAHEDRON LETTERS   50 ( 23 )   2801 - 2804   2009.6

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    DOI: 10.1016/j.tetlet.2009.03.157

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  • Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-kappa B Reviewed

    Yuichi Ishikawa, Miyuki Tachibana, Chino Matsui, Rika Obata, Kazuo Umezawa, Shigeru Nishiyama

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   19 ( 6 )   1726 - 1728   2009.3

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    DOI: 10.1016/j.bmcl.2009.01.107

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  • Synthesis of a spiroacetal moiety of antitumor antibiotic ossamycin by anodic oxidation Reviewed

    Eriko Honjo, Noriki Kutsumura, Yuichi Ishikawa, Shigeru Nishiyama

    TETRAHEDRON   64 ( 40 )   9495 - 9506   2008.9

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    DOI: 10.1016/j.tet.2008.07.078

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  • Synthesis and biological assessment of hemiacetal spiro derivatives towards development of efficient chemotherapeutic agent Reviewed

    Takahisa Ogamino, Sayo Ohnishi, Yuichi Ishikawa, Takeshi Sugai, Rika Obata, Shigeru Nishiyama

    SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS   7 ( 2 )   175 - 183   2006.3

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    DOI: 10.1016/j.stam.2005.10.004

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  • The first total synthesis of SB87-Cl and pestalone, novel bioactive benzophenone natural products Reviewed

    D Iijima, D Tanaka, M Hamada, T Ogamino, Y Ishikawa, S Nishiyama

    TETRAHEDRON LETTERS   45 ( 28 )   5469 - 5471   2004.7

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    DOI: 10.1016/j.tetlet.2004.05.063

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  • The first total synthesis and absolute stereochemistry of plakortone G from the Jamaican sponge Plakortis sp. Reviewed

    S Kowashi, T Ogamino, J Kamei, Y Ishikawa, S Nishiyama

    TETRAHEDRON LETTERS   45 ( 22 )   4393 - 4396   2004.5

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    DOI: 10.1016/j.tetlet.2004.03.169

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  • Synthesis of the BCD ring system of azaspiracid: Construction of the trispiro ring structure by the thioether approach Reviewed

    Yuichi Ishikawa, Shigeru Nishiyama

    Tetrahedron Letters   45 ( 2 )   351 - 354   2004.1

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    DOI: 10.1016/j.tetlet.2003.10.161

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  • Synthesis of (+/-)-pyranonaphthoquinone derivatives, a Cdc25A phosphatase inhibitor Reviewed

    A Shimbashi, Y Ishikawa, S Nishiyama

    TETRAHEDRON LETTERS   45 ( 5 )   939 - 941   2004.1

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    DOI: 10.1016/j.tetlet.2003.11.120

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  • Electrochemical synthesis of spiroisoxazole derivatives and its application to natural products Reviewed

    T Ogamino, Y Ishikawa, S Nishiyama

    HETEROCYCLES   61   73 - +   2003.12

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  • Biological activities of alpha-mangostin derivatives against acidic sphingomyelinase Reviewed

    M Hamada, K Iikubo, Y Ishikawa, A Ikeda, K Umezawa, S Nishiyama

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   13 ( 19 )   3151 - 3153   2003.10

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    DOI: 10.1016/S0960-894X(03)00719-4

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  • The first direct synthesis of alpha-mangostin, a potent inhibitor of the acidic sphingomyelinase Reviewed

    K Iikubo, Y Ishikawa, N Ando, K Umezawa, S Nishiyama

    TETRAHEDRON LETTERS   43 ( 2 )   291 - 293   2002.1

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    DOI: 10.1016/S0040-4039(01)02137-2

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  • (-)-(3S)-4-(2-{[4,4-dimethoxy-6-(benzyloxymethyl) perhydropyran-2-yl]methyl}-1,3-dithian-2-yl)-4-methyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)-pentan-1-ol Reviewed

    H Hosomi, S Ohba, K Ohmori, T Obitsu, Y Ogawa, Y Ishikawa, S Yamamura, S Nishiyama

    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS   56   E140 - E141   2000.4

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  • (+)-3-{(4S,5S)-5-[1,1-dimethyl-2-(phenylthio)ethyl]-2,2-dimethyl-1,3-dioxolan-4-yl}prop-2-yn-1-ol Reviewed

    H Hosomi, S Ohba, K Ohmori, T Obitsu, Y Ogawa, Y Ishikawa, S Yamamura, S Nishiyama

    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS   56   E142 - E143   2000.4

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  • Total synthesis of bryostatin 3 Reviewed

    K Ohmori, Y Ogawa, T Obitsu, Y Ishikawa, S Nishiyama, S Yamamura

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   39 ( 13 )   2290 - 2294   2000

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/1521-3773(20000703)39:13<2290::AID-ANIE2290>3.0.CO;2-6

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MISC

  • Biology-oriented diverted synthesis of glutamate analogs

    Masato Oikawa, Manami Chiba, Chikako Fujimoto, Yuichi Ishikawa

    AMINO ACIDS   47 ( 8 )   1690 - 1690   2015.8

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  • プロトアーキュレインBの合成研究

    OTSUKA KAZUNORI, ISHIKAWA YUICHI, TAKAMIZAWA SATOSHI, SAKAI RYUICHI, OIKAWA MASATO

    日本化学会講演予稿集   94th ( 4 )   1468   2014.3

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  • Dysibetaine CPa/CPbおよび類縁体の不斉全合成と天然物の絶対立体配置決定

    境倫宏, 田中健斗, 石川裕一, 酒井隆一, 及川雅人

    日本化学会講演予稿集   93rd ( 4 )   1220   2013.3

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  • (±)‐dysibetaine CPaの全合成およびその不斉合成戦略

    境倫宏, 佐々木翔太, 石川裕一, 酒井隆一, SWANSON G.T, 及川雅人

    日本化学会講演予稿集   92nd ( 4 )   1182   2012.3

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  • 天然物をモチーフにしたAMPA受容体阻害剤IKM‐159の類縁体の合成と活性

    菅俣祐太郎, 常盤一弥, 加曽利祐基, 片山理佐, 村上悦子, 石川裕一, 酒井隆一, 及川雅人

    日本化学会講演予稿集   92nd ( 4 )   1181   2012.3

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  • 天然物をモチーフとしたAMPA受容体阻害剤IKM‐159の不斉合成

    常盤一弥, 菅俣祐太郎, 石川裕一, 酒井隆一, 及川雅人

    日本化学会講演予稿集   92nd ( 4 )   1180   2012.3

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    J-GLOBAL

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  • (±)‐dysibetaine CPaおよび類縁体の全合成

    境倫宏, 佐々木翔太, 石川裕一, 酒井隆一, SWANSON G. T, 及川雅人

    天然有機化合物討論会講演要旨集   53rd   643-648 - 648   2011.9

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  • Structure-activity relationship of NF-kappa B inhibitor DHMEQ and preparation of soluble analog

    Chika Shimada, Tsuyoshi Saito, Yuichi Ishikawa, Shigeru Nishiyama, Kazuo Umezawa

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   26   S11 - S11   2010

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  • Discovery of a novel AP-1 function inhibitor DTCM-glutarimide derived from an antibiotic 9-methylstreptimidone

    Miyuki Tachibana, Yuichi Ishikawa, Shigeru Nishiyama, Kazuo Umezawa

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   24   S6 - S6   2009

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  • The first total synthesis of SB87-Cl and pestalone, novel bioactive benzophenone natural products

    D Iijima, D Tanaka, M Hamada, T Ogamino, Y Ishikawa, S Nishiyama

    TETRAHEDRON LETTERS   45 ( 28 )   5469 - 5471   2004.7

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  • The first total synthesis and absolute stereochemistry of plakortone G from the Jamaican sponge Plakortis sp.

    S Kowashi, T Ogamino, J Kamei, Y Ishikawa, S Nishiyama

    TETRAHEDRON LETTERS   45 ( 22 )   4393 - 4396   2004.5

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  • Synthetic studies on azaspiracid, a novel shellfish poison: Attempts to construct the ABCD ring system

    Y Ishikawa, S Nishiyama

    HETEROCYCLES   63 ( 3 )   539 - 565   2004.3

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  • Synthesis of the BCD ring system of azaspiracid: construction of the trispiro ring structure by the thioether approach

    Y Ishikawa, S Nishiyama

    TETRAHEDRON LETTERS   45 ( 2 )   351 - 354   2004.1

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  • Synthesis of the ABCD ring system of azaspiracid, a marine poison from Mytilus edulis

    Heterocycles   63 ( 4 )   885 - 893   2004

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  • Synthesis of (±)-pyranonaphthoquinone derivatives, a Cdc25A phosphatase inhibitor

    Tetrahedorn Letters   45 ( 5 )   939 - 941   2004

  • Biological activities of alpha-mangostin derivatives against acidic sphingomyelinase

    M Hamada, K Iikubo, Y Ishikawa, A Ikeda, K Umezawa, S Nishiyama

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   13 ( 19 )   3151 - 3153   2003.10

  • Electrochemical Synthesis of Spiroxazole Derivatives and its Application to Natural Products

    Heterocycles   61   73 - 78   2003

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  • The first direct synthesis of alpha-mangostin, a potent inhibitor of the acidic sphingomyelinase

    K Iikubo, Y Ishikawa, N Ando, K Umezawa, S Nishiyama

    TETRAHEDRON LETTERS   43 ( 2 )   291 - 293   2002.1

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  • Total synthesis of bryostatin 3

    K Ohmori, Y Ogawa, T Obitsu, Y Ishikawa, S Nishiyama, S Yamamura

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   39 ( 13 )   2290 - 2294   2000

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Presentations

  • Amphidinolide類の効率的合成法の開発

    荒川周, 石川裕一

    日本化学会第106春季年会(2026)  2026.3 

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    Event date: 2026.3

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  • ヘッジホッグシグナル伝達経路阻害剤 Taepeenin D の合成研究

    前野 和明, 石川 裕一

    日本化学会第105春季年会(2025)  2025.3 

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    Event date: 2025.3

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  • 新規抗がん剤リード化合物Taepeenin Dの合成研究

    前野和明, 折田悠一, 石川裕一

    第85回有機合成化学協会関東シンポジウム(新潟シンポジウム)  2023.11 

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  • Synthetic Studies on Terpenes with Hedgehog and Wnt Signaling Pathway Inhibitory Activities

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    Event date: 2023.3

    Presentation type:Oral presentation (general)  

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  • Synthetic Studies on Terpenes with Intracellular Signaling Pathway Inhibitory Activity

    2022.3 

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    Event date: 2022.3

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  • Synthetic studies of Haebaruol

    Kotaro Ringa, Yuichi Ishikawa

    2021.3 

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    Event date: 2021.3

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  • Synthetic studies of Scopadulciol

    Arimi Takahashi, Yuichi Ishikawa

    2021.3 

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  • 新規抗がん剤リード化合物 Scopadulciol の合成研究

    高橋 愛梨美, 石川 裕一

    第78回有機合成化学協会関東支部シンポジウム  2019.11 

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  • 新規抗がん剤リード化合物Taepeenin Dの合成研究

    星野莉輝、折田悠一、石川裕一

    第82回有機合成化学協会関東支部シンポジウム  2022.5 

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  • 抗腫瘍性マクロライド化合物amphidinolide B, G, Hの全合成

    原 彰宏, 森本 諒, 岩﨑 祐樹, 仮屋 光馬, 石川 裕一, 西山 繁

    第53回天然有機化合物討論会  2011.9 

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  • DTCM-glutarimideによるマウスメラノーマ細胞の浸潤抑制とanoikis誘導

    兼田 亜弓, 石川 裕一, 西山 繁, 梅澤 一夫

    第52回天然有機化合物討論会  2010.9 

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  • -マンゴスチンとその関連物質の合成と生物活性

    飯久保 一彦, 石川 裕一, 濵田 基子, 田中 大輔, 池田 彩, 梅澤 一夫, 西山 繁

    第44回天然有機化合物討論会  2002.10 

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  • ブリオスタチン類の合成研究

    大森 建, 小櫃 徹夫, 小川 泰之, 石川 裕一, 西山 繁, 山村 庄亮

    第40回天然有機化合物討論会  1998.10 

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  • 電解合成法・タリウム酸化法を駆使したイソジチロシン類の全合成研究

    田邊 貴將, 宇野 加奈子, 森 千春, 内藤 雄, 村山 響子, 小畠 りか, 石川 裕一, 西山 繁

    第50回天然有機化合物討論会  2008.10 

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  • 9-methylstreptimidone由来新規iNOS誘導阻害剤の合成と作用機構

    橘 みゆき, 石川 裕一, 西山 繁, 梅澤 一夫

    第50回天然有機化合物討論会  2008.9 

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  • 新規転写因子AP-1活性阻害剤DTCM-glutarimideの作用機構と生物活性

    兼田 亜弓, 橘 みゆき, 石川 裕一, 西山 繁, 梅澤 一夫

    第51回天然有機化合物討論会  2009.10 

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  • 抗腫瘍性マクロライド化合物amphidinolide類の合成研究

    原 彰宏, 岩﨑 祐樹, 森本 諒, 若松 孝行, 石川 裕一, 西山 繁

    第51回天然有機化合物討論会  2009.10 

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  • (+/-)-dysibetaine CPaおよび類縁体の全合成

    境 倫宏, 佐々木 翔太, 石川 裕一, 酒井 隆一, G. T. Swanson, 及川 雅人

    第53回天然有機化合物討論会  2011.9 

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  • プロトアーキュレインBの合成研究

    大塚 一憲, 石川 裕一, 高見澤 聡, 酒井 隆一, 及川 雅人

    日本化学会第94春季年会  2014.3 

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  • 光学活性アミンをUgi 4成分連結反応に用いるα-アミノ酸の合成法

    菅俣 祐太郎, 鈴木 雄貴, 石川 裕一, 及川 雅人

    第54回天然有機化合物討論会  2012.9 

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  • 超原子価ヨウ素試薬を活用した含窒素化合物の合成研究

    梶山 大地, 斉藤 毅, 井上 桂輔, 山口 智史, 石川 裕一, 西山 繁

    第54回天然有機化合物討論会  2012.9 

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  • 1-Hydroxy-2-methyl-2-propyl isocyanide による Ugi 反応と post-Ugi 反応

    福島 孝一, 菅俣 祐太郎, 千葉 まなみ, 石川 裕一, 及川 雅人

    第66回有機合成化学協会関東支部シンポジウム  2013.11 

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  • 海綿由来GABA類縁体とその部分構造の合成研究

    菅野 由香, 境 倫宏, 田中 健斗, 石川 裕一, 及川 雅人

    第55回天然有機化合物討論会  2013.9 

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  • 有機触媒による不斉シクロプロパン化と、配座固定アミノ酸合成への応用

    田中 健斗, 菅野 由香, 石川 裕一, 及川 雅人

    日本化学会第94春季年会  2014.3 

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  • 7-Oxanorbornene類のドミノメタセシス反応によるシナプス受容体リガンド候補化合物の合成研究

    千葉 まなみ, 藤本 千賀子, 石川 裕一, 及川 雅人

    日本化学会第94春季年会  2014.3 

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  • Clickableダイシハーベインの合成研究

    福島 孝一, 石川 裕一, 及川 雅人

    日本化学会第94春季年会  2014.3 

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  • Ugi 4成分連結反応を用いた、α,α-二置換アミノ酸の合成研究

    菅俣 祐太郎, 吉岡 広大, 石川 裕一, 及川 雅人

    日本化学会第94春季年会  2014.3 

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  • メロジテルペノイドStrongylophorine類縁体の合成研究

    内山 大貴, 石川 裕一, 及川 雅人

    日本化学会第94春季年会  2014.3 

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  • ダイシベタインCPbの合成研究

    田中 健斗, 石川 裕一, 及川 雅人

    日本化学会第94春季年会  2014.3 

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  • ストロンギロフォリンアナログの合成研究

    内山 大貴, 石川 裕一

    日本化学会第95春季年会  2015.3 

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  • 新規抗がん剤創製を指向したストロンギロフォリンアナログの合成研究

    内山 大貴, 及川 侑也, 石川 裕一, 及川 雅人

    第56回天然有機化合物討論会  2014.10 

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  • 立体選択的 Prins-Ritter 反応によるシナプス受容体リガンドの 合成化学的開発の試み

    千葉 まなみ, 藤本 千賀子, 石川 裕一, 及川 雅人

    日本化学会第96春季年会  2016.3 

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  • プロトアーキュレインBの合成研究

    菅原 啓, 大塚 一憲, 石川 裕一, 及川 雅人

    第57回天然有機化合物討論会  2015.9 

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  • 新規抗がん剤創製を指向したStrongylophorineアナログの合成研究

    白澤卓也, 内山大貴, 及川雅人, 石川裕一

    第109回有機合成シンポジウム  2016.6 

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  • プロトアーキュレイン B の合成研究

    菅原 啓, 石川 裕一, 及川 雅人

    日本化学会第96春季年会  2016.3 

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  • クロマノールの効率的な合成法と、それによるStrongylophorineアナログの合成研究

    白澤卓也, 及川雅人, 石川裕一

    第72回有機合成化学協会関東支部シンポジウム  2016.11 

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  • エナミドのN-アルキル化を鍵反応とするprotoaculeine B の合成研究

    塩﨑宏樹, 石川裕一, 及川雅人

    第72回有機合成化学協会関東支部シンポジウム  2016.11 

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  • Studies on asymmetric synthesis of excitatory agent IKM-154

    ITAGAKI Hiyori, ISHIKAWA Yuichi, OIKAWA Masato

    2017.3 

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  • Pd 触媒を用いたクロマノール構築による HIF-1 活性化経路阻 害剤 Strongylophorine 類の合成研究

    白澤卓也, 及川雅人, 石川裕一

    日本化学会第97春季年会  2017.3 

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  • Synthetic studies on marine natural polyamine protoaculeine-B

    SHIOZAKI, Hiroki, ISHIKAWA Yuichi, OIKAWA Masato

    2017.3 

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  • 新規抗がん剤リード化合物Scopadulciolの合成研究

    樋口博之, 及川雅人, 石川裕一

    第73回有機合成化学協会関東支部シンポジウム  2017.5 

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  • 神経興奮性IKM-154の不斉合成研究

    板垣ひより, 石川裕一, 及川雅人

    第73回有機合成化学協会関東支部シンポジウム  2017.5 

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  • 天然物をモチーフとする神経生理活性化合物の創製の試み

    板垣 ひより, 諸熊 賢治, 石川 裕一, 及川 雅人

    第59回天然有機化合物討論会  2017.9 

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  • シナプス受容体に活性反転を引き起こすリガンドの不斉合成研究

    及川雅人, 板垣ひより, 石川裕一

    日本ケミカルバイオロジー学会第12回年会  2017.6 

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  • Studies on asymmetric synthesis of artificial glutamate analogs having opposite neuronal activities

    TSUKAMOTO Shuntaro, MOROKUMA Kenji, ISHIKAWA Yuichi, OIKAWA Masato

    2018.3 

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  • Synthetic studies of marine polyamine

    MIYAHARA Masayoshi, SHIOZAKI Hiroki, ISHIKAWA Yuichi, OIKAWA Masato

    2018.3 

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  • Skeletal diversity from cis-2-alkenylcycloalkan-1-ol

    NODA Taiki, HLOKOANE Oriel, ISHIKAWA Yuichi, OIKAWA Masato

    2018.3 

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  • 新規抗がん剤リード化合物Scopadulciolの合成研究

    高橋愛梨美, 石川 裕一

    第77回有機合成化学協会関東支部シンポジウム  2019.5 

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  • 新規抗がん剤リード化合物 Taepeenin D の合成研究

    遠藤翔一, 石川 裕一

    第78回有機合成化学協会関東支部シンポジウム  2019.11 

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Research Projects

  • 天然物の活性基本構造を基盤とした新規シグナル伝達経路阻害物質の選択的合成

    Grant number:23K04946  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    石川 裕一

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • 天然由来シグナル伝達経路阻害物質の活性中核構造の解明

    2018.4 - 2022.3

    科研費:基盤研究(C) 

    石川 裕一

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    Authorship:Principal investigator  Grant type:Competitive

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  • 天然有機化合物を基盤とした新規ヘッジホッグシグナル阻害剤の創製

    2013.4 - 2016.3

    科研費  基盤研究(C) 

    石川 裕一

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    Authorship:Principal investigator  Grant type:Competitive

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  • 天然有機化合物を基盤とした新規低酸素誘導因子阻害剤の創製

    2010 - 2011

    科研費 若手研究(B) 

    石川 裕一

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    Authorship:Principal investigator  Grant type:Competitive

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  • 発癌予防薬を指向したオルニチンデカルボキシラーゼ発現阻害剤saliniketal類の合成と構造−活性相関研究

    2008

    服部報公会 工学研究奨励援助 

    石川 裕一

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    Authorship:Principal investigator  Grant type:Competitive

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  • 新規食中毒原因貝毒アザスピロ酸類の合成研究とその作用機作の解明

    2003 - 2004

    科研費 若手研究(B) 

    石川 裕一

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    Authorship:Principal investigator  Grant type:Competitive

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