Updated on 2025/06/02

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写真a

 
Toshinori Iwai
 
Organization
Yokohama City University Hospital Oral and Maxillofacial Surgery/Orthodontics Associate Professor
Title
Associate Professor
Profile

口腔顎顔面領域における低侵襲手術の開発に取り組んでいます.
内視鏡やナビゲーションシステムを用いることでこれまででは実現できなかった低侵襲・安全・確実な手術が可能となり,患者さんのQOLの向上が期待できます.
低侵襲手術を希望される患者さんが日本全国,さらには海外からも受診しています.

External link

Degree

  • 博士(医学) ( 横浜市立大学 )

Research Interests

  • シミュレーション

  • 唾液腺

  • 内視鏡

  • ナビゲーション

  • 医工連携

  • 低侵襲手術

  • バーチャルリアリティ

  • 流体解析

Research Areas

  • Life Science / Surgical dentistry  / 口腔顎顔面外科学・内視鏡外科学・コンピュータ外科学・シミュレーション外科学・睡眠歯科学

Education

  • Tokyo Medical and Dental University

    1996.4 - 2002.3

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Research History

  • 横浜市立大学附属病院   歯科・口腔外科・矯正歯科   准教授

    2022.4

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  • Yokohama City University   Hospital, Dentistry/Oral and Maxillofacial Surgery/Orthodontics   Lecturer

    2020.4 - 2022.3

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  • 横浜市立大学附属病院

    2019.4 - 2020.3

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  • Yokohama City University   Advanced Medical Research Center

    2012.9 - 2016.3

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  • Yokohama City University   Hospital, Dentistry/Oral and Maxillofacial Surgery/Orthodontics   Assistant Professor

    2012.8 - 2019.3

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  • 横浜市立大学附属病院 歯科・口腔外科   助教

    2010.4 - 2012.7

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  • 横浜市立大学附属病院 歯科・口腔外科   指導診療医

    2007.4 - 2010.3

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  • 横浜市立大学附属病院 歯科・口腔外科   常勤特別職診療医

    2006.5 - 2007.3

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  • ドイツ フライブルク大学口腔顎顔面外科留学(Clinical fellow)

    2006.3 - 2006.4

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  • Yokohama City University   Plastic and Reconstructive Surgery, Hospital

    2005.4 - 2006.4

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  • 横浜市立港湾病院 歯科口腔外科   専修医

    2004.4 - 2005.3

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  • 横浜市立大学医学部附属病院 歯科・口腔外科   研修医

    2002.5 - 2004.3

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Professional Memberships

  • JAPAN SOCIETY FOR ORAL TUMORS

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  • 日本口腔診断学会

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  • JAPAN SOCIETY FOR HEAD AND NECK CANCER

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  • 日本顎顔面再建先進デジタルテクノロジー学会

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  • 日本睡眠歯科学会

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  • THE JAPANESE SOCIETY FOR JAW DEFORMITIES

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  • JAPANESE SOCIETY OF ORAL AND MAXILLOFACIAL SURGEONS

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Committee Memberships

  • 日本顎変形症学会   認定医制度委員会委員  

    2024.10   

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    Committee type:Academic society

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  • 日本顎変形症学会   編集査読・用語検討委員会委員  

    2024.10   

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    Committee type:Academic society

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  • Frontiers in Oncology   Associate Editor  

    2023.7   

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  • 日本シミュレーション外科学会   理事  

    2022.12   

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    Committee type:Academic society

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  • 日本顎変形症学会   認定審査会(口腔外科)委員  

    2022.11   

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    Committee type:Academic society

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  • Frontiers in Oncology   Review Editor  

    2022.8   

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  • 日本顎変形症学会   評議員  

    2022.1   

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  • 日本口腔外科学会   新型コロナウィルス対策検討委員会 システマティックレビュー担当委員  

    2020.8 - 2021.8   

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    Committee type:Academic society

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  •   日本顎顔面再建先進デジタルテクノロジー学会 理事  

    2017.1   

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  • 日本シミュレーション外科学会   評議員  

    2016.12   

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  •   International Journal of Dentistry and Oral Science. Editorial Board Member  

    2015.10   

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    Committee type:Academic society

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  •   Journal of Surgery and Surgical Research. Editorial Board Member  

    2015.9   

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    Committee type:Other

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  •   Archives of Otolaryngology and Rhinology. Editorial Board Member  

    2015.9   

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  •   International Journal of Oral and Craniofacial Science. Editorial Board Member  

    2015.9   

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  •   International Journal of Surgery and Surgical Procedures. Editorial Board Member  

    2015.8   

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  •   Advances in Modern Oncology Research. Editorial Board Member  

    2015.8   

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    Committee type:Other

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  • AOCMF JAPAN   Delegate(代議員)  

    2014.1   

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    Committee type:Other

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  • 日本顎顔面再建先進デジタルテクノロジー学会   評議員  

    2013.4   

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  •   Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. Reviewer (Section: Oral and Maxillofacial Surgery)  

    2013.1   

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  •   Medicina Oral Patologia Oral y Cirugia Bucal. Editorial Board Member (Section: Oral Surgery)  

    2012.9   

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    Committee type:Other

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Papers

  • Submandibular schwannoma arising from the hypoglossal nerve radiologically masquerading as submandibular gland tumor Reviewed

    Iwai T, Sugiyama S, Ishikawa S, Mitsudo K

    J Dent Sci   20 ( 2 )   1325 - 1327   2025.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Submandibular schwannoma arising from the hypoglossal nerve radiologically masquerading as submandibular gland tumor.pdf

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  • Sialo-cutaneous fistula caused by submandibular gland sialolith Reviewed

    Sugiyama S, Iwai T, Kaneko T, Mitsudo K

    J Dent Sci   20 ( 2 )   1343 - 1345   2025.4

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Sialo-cutaneous fistula caused by submandibular gland sialolith.pdf

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  • Bilateral mandibular osteonecrosis associated with imatinib monotherapy for a patient with chronic myeloid leukemia Reviewed

    Yajima Y, Iwai T, Sugiyama S, Mitsudo K

    J Dent Sci   20 ( 2 )   1373 - 1374   2025.4

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Bilateral mandibular osteonecrosis associated with imatinib monotherapy for a patient with chronic myeloid leukemia.pdf

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  • Submandibular gland obstruction caused by phlebolith masquerading as sialolith Reviewed

    Sugiyama S, Iwai T, Yajima Y, Mitsudo K

    J Dent Sci   20 ( 2 )   1346 - 1347   2025.4

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Submandibular gland obstruction caused by phlebolith masquerading as sialolith.pdf

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  • Intentional intraoperative removal of impacted maxillary third molar to facilitate posterior repositioning of the maxilla in Le Fort I osteotomy Reviewed

    Iwai T, Minamiyama S, Sugiyama S, Honda K, Mitsudo K

    J Maxillofac Oral Surg   24 ( 1 )   107 - 109   2025.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: s12663-024-02428-6.pdf

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  • Endoscopic apicoectomy with preservation of Schneiderian membrane for radicular cyst of the maxillary molar Reviewed

    Sugiyama S, Iwai T, Minamiyama S, Honda K, Mitsudo K.

    J Maxillofac Oral Surg   24 ( 1 )   311 - 312   2025.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: s12663-024-02397-w.pdf

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  • Maxillofacial trunk identified by three-dimensional computed tomography angiography Reviewed

    Iwai T, Sugiyama S, Koizumi T, Mitsudo K

    Surg Radiol Anat   47 ( 1 )   25   2025.1

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    Authorship:Lead author, Last author   Language:English   Publishing type:Research paper (scientific journal)  

    File: MFT.pdf

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  • Migration of submandibular gland sialolith into the subcutaneous tissue Reviewed

    Iwai T, Sugiyama S, Kitajima H, Mitsudo K

    J Dent Sci   2025

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  • Submandibular gland mucocele caused by submental liposuction Reviewed

    Kaneko T, Iwai T, Sugiyama S, Oguri S, Mitsudo K

    J Oral Maxillofac Surg Med Pathol   2025

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

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  • A novel classification proposal of mandibular defects for mandibular reconstruction Reviewed

    Iwai T, Sugiyama S, Yajima Y, Mitsudo K

    J Maxillofac Oral Surg   2025

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  • Decreased collagen XII expression and increased reactive oxygen species production in levofloxacin-treated tendon Reviewed

    Kobayashi T, Sato T, Isozaki Y, Okubo M, Aoda S, Iwai T, Nogami S, Ito K

    Sci J Clin Med   13 ( 4 )   63 - 70   2024.12

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    File: j.sjcm.20241304.11.pdf

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  • Simple method with periodontal probe for intraoral removal of recurrent deep hilar/intraparenchymal submandibular gland stone under local anesthesia Reviewed

    Iwai T, Yajima Y, Sugiyama S, Mitsudo K

    J Dent Sci   19 ( 4 )   2455 - 2457   2024.10

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    File: 1-s2.0-S1991790224002095-main.pdf

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  • Simple inferior border osteotomy to prevent bad split during bilateral sagittal split osteotomy Reviewed

    Sugiyama S, Iwai T, Honda K, Mitsudo K

    J Dent Sci   19 ( 4 )   2441 - 2442   2024.10

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: 1-s2.0-S1991790224002277-main.pdf

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  • Submandibular gland mucocele masquerading as plunging ranula Reviewed

    Sugiyama S, Iwai T, Kitajima H, Hirota M, Mitsudo K

    Ear Nose Thorat J   103 ( 3 )   NP617 - NP618   2024.10

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: sugiyama-et-al-2022-submandibular-gland-mucocele-masquerading-as-plunging-ranula.pdf

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  • A submandibular mass with cystic component Reviewed

    Ishikawa S, Iwai T, Sugiyama S, Hirota M, Mitsudo K

    Ear Nose Thorat J   103 ( 10 )   NP619 - NP621   2024.10

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: ishikawa-et-al-2022-a-submandibular-mass-with-cystic-component.pdf

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  • Ultrasound-guided intranodal lymphangiography with lipiodol as a diagnostic and therapeutic approach for chyle leak after neck dissection Reviewed

    Sugiyama S, Iwai T, Oguri S, Mitsudo K

    J Dent Sci   19 ( 2 )   1248 - 1250   2024.4

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    File: 1-s2.0-S1991790223003859-main.pdf

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  • Endoscopically-assisted intraoral marginal mandibulectomy with a cutting guide for mandibular posterior gingival carcinoma Reviewed

    Iwai T, Sugiyama S, Oguri S, Mitsudo K

    J Dent Sci   19 ( 2 )   1245 - 1247   2024.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: 1-s2.0-S1991790223003896-main.pdf

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  • Limitation of PET/CT for screening of synchronous upper gastrointestinal cancer in oral cancer patients Reviewed

    Iwai T, Ishikawa S, Ideta Y, Sugiyama S, Hayashi Y, Minamiyama S, Kitajima H, Mitsudo K

    J Oral Maxillofac Surg Med Pathol   36 ( 2 )   191 - 194   2024.3

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    File: JOMSMP.pdf

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  • Occipital artery arising from the superior aspect of the carotid bifurcation: a rare anatomical variant Reviewed

    Sugiyama S, Iwai T, Kioi M, Mitsudo K

    Indian J Surg   86 ( 1 )   253 - 254   2024.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: 67_JPR_D_22_00225.pdf

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  • Intraoral approach for oral floor reconstruction with the submandibular gland flap Reviewed

    Iwai T, Hirabayashi M, Kioi M, Mitsudo K

    J Dent Sci   19 ( 1 )   656 - 658   2024.1

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    File: Intraoral approach SMG flap.pdf

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  • Patient with severe acute respiratory syndrome coronavirus 2 nosocomial infection undergoing superselective intra-arterial chemoradiation therapy for maxillary gingival carcinoma: A case report Reviewed

    Koizumi T, Ohya T, Oguri S, Iwai T, Kioi M, Mitsudo K

    Oral Sci Int   21 ( 1 )   137 - 142   2024.1

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    File: Oral Science International - 2023 - Koizumi.pdf

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  • Midline supramylohyoid mucocele arising from ectopic salivary gland tissue Reviewed

    Sugiyama S, Iwai T, Minamiyama S, Mitsudo K

    J Dent Sci   19 ( 1 )   698 - 700   2024.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Midline mucocele.pdf

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  • Pathological mandibular fractures following idiopathic resorption of bilateral mandibular rami and coronoid processes Reviewed

    Yoshii H, Iwai T, Sugiyama S, Mitsudo K

    J Dent Sci   19 ( 1 )   691 - 692   2024.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Pathological fractures.pdf

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  • Basal cell adenocarcinoma of the soft palate with multiple bone metastases Reviewed

    Hayashi Y, Iwai T, Sugiyama S, Mitsudo K

    J Dent Sci   19 ( 1 )   722 - 723   2024.1

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    File: BCA palate.pdf

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  • A simple method to use a self-retaining cheek retractor during oral surgery under general anesthesia with orotracheal intubation Reviewed

    Sugiyama S, Iwai T, Honda K, Mitsudo K

    J Dent Sci   19 ( 1 )   673 - 674   2024.1

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    File: Simple method anglewider.pdf

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  • Endoscopically-assisted intraoral vertical ramus osteotomy to prevent injury of the maxillary artery and mandibular neurovascular bundle Reviewed

    Iwai T, Sugiyama S, Honda K, Mitsudo K

    J Dent Sci   19 ( 1 )   671 - 672   2024.1

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    File: Endoscope IVRO.pdf

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  • Transantral apicoectomy for radicular cyst of maxillary molar following downfracture in Le Fort I osteotomy Reviewed

    Honda K, Iwai T, Sugiyama S, Mitsudo K

    J Dent Sci   19 ( 1 )   684 - 685   2024.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Transantral apicoectomy.pdf

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  • An effective compression method with a hydrophilic vinyl polysiloxane impression material on the supraclavicular fossa as conservative treatment of chyle leak after neck dissection Reviewed

    Sugiyama S, Iwai T, Oguri S, Mitsudo K

    J Dent Sci   19 ( 1 )   682 - 683   2024.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Compression method ND.pdf

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  • A submandibular mass with parapharyngeal extention Reviewed

    Minamiyama S, Iwai T, Sugiyama S, hirota M, Mitsudo K

    Ear Nose Throat J   2024

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  • Endoscopically-assisted intraoral resection of osteochondroma of the mandibular condyle with a piezoelectric surgical device Reviewed

    Iwai T, Sugiyama S, Ohashi N, Hirota M, Ito K, Mitsudo K

    Cranio   42 ( 3 )   305 - 308   2024

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    File: Endoscopically-assisted intraoral resection of osteochondroma of the mandibular condyle with a piezoelectric surgical device (1).pdf

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  • Mandibular autorotation revisited: A retrospective study of accuracy and stability of maxillary impaction in retrognathic patients with condylar osteoarthritis Reviewed

    Fujita K, Hirota M, Usumi-Fujita R, Takasu H, Yamashita Y, Honda K, Imai H, Iwai T, Omura S, Ono T, Mitsudo K

    J Craniomaxillofac Surg   52 ( 2 )   165 - 169   2024

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    File: 1-s2.0-S1010518223001506-main.pdf

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  • Huge plunging ranula extending into multiple spaces Reviewed

    Sugiyama S, Iwai T, Minamiyama S, Mitsudo K

    Ear Nose Throat J   2024

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  • Synergistic enhancement of protein recruitment and retention by implant surface microtopography and superhydrophilicity in a computational fluid dynamics model Reviewed

    Kitajima H, Hirota M, Iwai T, Mitsudo K, Saruta J, Ogawa T

    Int J Mol Sci   24 ( 21 )   15618   2023.11

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    File: ijms-24-15618.pdf

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  • A novel orthognathic surgery with a half-millimeter accuracy for the maxillary positioning using prebent plates and computer-aided design and manufacturing osteotomy guide Reviewed

    Yamashita Y, Imai H, Takasu H, Omura S, Fujita K, Iwai T, Hirota M, Mitsudo K

    J Craniofac Surg   34 ( 7 )   2087 - 2091   2023.10

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    File: a_novel_orthognathic_surgery_with_a.41.pdf

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  • Submandibular gland metastasis as the initial manifestation of lung small cell carcinoma Reviewed

    Iwai T, Hirabayashi M, Sugiyama S, Mitsudo K

    J Dent Sci   18 ( 4 )   1915 - 1917   2023.10

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    File: 1-s2.0-S1991790223002088-main.pdf

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  • Horizontal alveolar transport distraction osteogenesis to stabilize removable prosthesis after mandibular reconstruction Reviewed

    Iwai T, Sugiyama S, Hirota M, Mitsudo K

    J Dent Sci   18 ( 4 )   1895 - 1896   2023.10

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    File: 1-s2.0-S1991790223002271-main.pdf

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  • Optimization of blood and protein flow around superhydrophilic implant surfaces by promoting contact hemodynamics Reviewed

    Kitajima H, Hirota M, Osawa K, Iwai T, Saruta J, Mitsudo K, Ogawa T

    J Prosthodont Res   67 ( 4 )   568 - 582   2023.10

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    File: 67_JPR_D_22_00225.pdf

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  • Metastatic neuroendocrine carcinoma to the mandibular gingiva from the duodenum papilla Reviewed

    Iwai T, Sugiyama S, Ohashi N, Mitsudo K

    Oral Oncol Rep   7   100052   2023.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: 1-s2.0-S2772906023000420-main.pdf

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  • Guidewire perforation into the oral cavity from the deep lingual artery during retrograde superselective intra-arterial catheterization for a tongue cancer patient Reviewed

    Iwai T, Hirabayashi M, Koizumi T, Mitsudo K

    Indian J Surg   85 ( 4 )   982 - 984   2023.8

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    File: s12262-022-03595-x.pdf

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  • The effects of a biomimetic hybrid meso- and nano-scale surface topography on blood and protein recruitment in a computational fluid dynamics implant model Reviewed

    Kitajima H, Hirota M, Osawa K, Iwai T, Mitsudo K, Saruta J, Ogawa T

    Biomimetics   8 ( 4 )   376   2023.8

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    File: biomimetics-08-00376.pdf

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  • Metastatic angiosarcoma of the mandibular gingiva Reviewed

    Iwai T, Yajima Y, Oguri S, Mitsudo K

    Indian J Surg   85 ( 3 )   659 - 661   2023.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Metastatic angiosarcoma.pdf

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  • Pectoralis major myocutaneous flap revisited as a workhorse for reconstruction for defects in the upper arm: A case report Reviewed

    Mikami T, Homma Y, Tamanoi Y, Yabuki Y, Kawabata Y, Kato I, Iwai T, Shimada K, Maegawa J

    J Nippon Med Sch   90 ( 3 )   288 - 293   2023.6

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    File: 090030288.pdf

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  • Sublingual gland herniation masquerading as submandibular lesion Reviewed

    Iwai T, Sugiyama S, Ishikawa S, Mitsudo K

    Indian J Surg   85 ( 2 )   438 - 439   2023.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: s12262-022-03431-2.pdf

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  • Mucocele arising from ectopic salivary gland tissue between the geniohyoid muscles Reviewed

    Iwai T, Minamiyama S, Sugiyama S, Mitsudo K

    Indian J Surg   85 ( 1 )   186 - 188   2023.2

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    File: Mucocele.pdf

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  • Multiple schwannomas arising in the midline space between the bilateral genioglossus muscles and left submandibular space Reviewed

    Iwai T, Minamiyama S, Mitsudo K

    J Craniofac Surg   34 ( 1 )   e61 - e63   2023.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Multiple_Schwannomas_Arising_in_the_Midline_Space.105.pdf

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  • Huge submandibular gland mucocele with diagnostic difficulties Reviewed

    Iwai T, Minamiyama S, Mitsudo K

    J Craniofac Surg   33 ( 8 )   e784 - e785   2022.11

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    File: Huge_Submandibular_Gland_Mucocele_With_Diagnostic.82.pdf

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  • A solitary asymptomatic submandibular mass Reviewed

    Iwai T, Minamiyama S, Mitsudo K

    Eur Ann Otorhinolaryngol Head Neck Dis   139 ( 5 )   309 - 310   2022.10

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  • Clinical anatomy of feeding artery of the submandibular gland Reviewed

    Iwai T, Sugiyama S, Minamiyama S, Oguri S, Mitsudo K

    J Craniofac Surg   33 ( 7 )   2256 - 2257   2022.10

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  • Lymphatic malformation in the buccal region Reviewed

    Iwai T, Minamiyama S, Sugiyama S, Mitsudo K

    Eur Ann Otorhinolaryngol Head Neck Dis   139 ( 5 )   313 - 314   2022.10

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  • A solitary, asymptomatic cystic lesion in the submandibular region Reviewed

    Iwai T, Minamiyama S, Mitsudo K

    Eur Ann Otorhinolaryngol Head Neck Dis   139 ( 5 )   305 - 307   2022.10

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  • Sentinel lymph node biopsy with a handheld cordless magnetic probe following preoperative MR lymphography using superparamagnetic iron oxide for clinically N0 early oral cancer: A feasibility study Reviewed

    Sugiyama S, Iwai T, Baba J, Oguri S, Kuwahata A, Sekino M, Kusakabe M, Mitsudo K

    J Stomatol Oral Maxillofac Surg   123 ( 5 )   521 - 526   2022.10

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  • Intraosseous schwannoma of the mandible masquerading as radicular cyst of the molar Reviewed

    Iwai T, Sugiyama S, Hayashi Y, Hirota M, Mitsudo K

    Ear Nose Throat J   101 ( 5 )   294 - 296   2022.6

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  • Intraoral styloidectomy using an endoscope with tissue retractor Reviewed

    Iwai T, Iida M, Sugiyama S, Mitsudo K

    J Craniofac Surg   33 ( 4 )   1201 - 1202   2022.6

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  • A simple method with a sterilized surgical glove for removal of stripped screw Reviewed

    Sugiyama S, Iwai T, Honda K, Mitsudo K

    J Stomatol Oral Maxillofac Surg   123 ( 3 )   e43 - e44   2022.6

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    File: 1-s2.0-S2468785521001919-main.pdf

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  • Anatomical relationship between the lingual nerve and submandibular duct Reviewed

    Iwai T, Sugiyama S, Oguri S, Mitsudo K

    J Craniofac Surg   33 ( 3 )   949 - 950   2022.5

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    File: Anatomical_Relationship_Between_the_Lingual_Nerve.56.pdf

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  • Pathological changes in the lymphatic system of patients with secondary lower limb lymphedema based on single photon-emission computed tomography/computed tomography/lymphoscintigraphy images Reviewed

    Fujiyoshi T, Miakmi T, Hashimoto K, Asano S, Adachi E, Kagimoto S, Yabuki Y, Kitayama S, Matsubara S, Maegawa J, Iwai T, Ishibe A, Miyagi E, Kaneta T

    Lymphat Res Biol   20 ( 2 )   144 - 152   2022.4

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  • A 3-dimensional finite element analysis of resected mandibular bone to determine the most stable implant positions for a fixed prosthesis Reviewed

    Kosugi Y, Hirota M, Tamai N, Takasu H, Iwai T, Mitsudo K

    J Oral Implantol   48 ( 2 )   84 - 91   2022.4

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  • Endoscopically-assisted intraoral removal of infrageniohyoid dermoid cyst Reviewed

    Iwai T, Sugiyama S, Kitajima H, Hirota M, Mitsudo K

    Ear Nose Throat J   101 ( 1 )   30 - 32   2022.1

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  • Malignant transformation of buccal mucosa leukoplakia in a patient with dyskeratosis congenita Reviewed

    Ohashi N, Iwai T, Ogawa M, Yokoo S, Mitsudo K

    Ear Nose Throat J   101 ( 1 )   27 - 29   2022.1

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  • Endoscopically-assisted intraoral resection of lipoma in the masticator space Reviewed

    Iwai T, Sugiyama S, Hirota M, Mitsudo K

    Ear Nose Throat J   101 ( 1 )   33 - 35   2022.1

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  • Ectopic thyroid cyst of the lateral neck Reviewed

    Sugiyama S, Iwai T, Hirota M, Mitsudo K

    Ear Nose Throat J   100 ( 10 Suppl )   1076S - 1078S   2021.12

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  • Endoscopically assisted resection of a cervical multicystic lymphatic malformation in an adult Reviewed

    Sugiyama S, Iwai T, Mikami T, Hibiya T, Maegawa J

    Ear Nose Throat J   100 ( 10 Suppl )   1079S - 1081S   2021.12

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  • Oral candidiasis caused by ciclesonide in a patient with COVID-19 pneumonia: A case report and literature review Reviewed

    Ohashi N, Ideta Y, Takeda A, Iwai T, Kioi M, Miyazaki A, Mitsudo K

    SAGE Open Med Case Rep   9   2050313X211048279   2021.9

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  • MR lymphography with superparamagnetic iron oxide for sentinel lymph node mapping of clinically N0 oral cancer: A pilot study Reviewed

    Sugiyama S, Iwai T, Baba J, Oguri S, Izumi T, Sekino M, Kusakabe M, Mitsudo K

    Dentomaxillofac Radiol   50 ( 4 )   20200333   2021.5

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  • Sentinel lymph node mapping of clinically N0 early oral cancer: a diagnostic pitfall on CT lymphography Reviewed

    Sugiyama S, Iwai T, Izumi T, Baba J, Oguri S, Hirota M, Mitsudo K

    Oral Radiol   37 ( 2 )   251 - 255   2021.4

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    File: Sugiyama2021_Article_SentinelLymphNodeMappingOfClin.pdf

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  • Trigeminocardiac reflex during bilateral sagittal split osteotomy Reviewed

    Sugiyama S, Iwai T, Honda K, Mitsudo K

    J Dent Sci   16 ( 2 )   782 - 783   2021.3

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  • Sporadic Burkitt lymphoma initially presented as orofacial manifestations in an 8-year-old boy: a case report and mini-review Reviewed

    Ohashi N, Iwai T, Nakamori Y, Iida M, Osawa K, Sugiyama S, Kitajima H, Minamiyama S, Yamanaka S, Shiiba N, Mitsudo K

    J Oral Maxillofac Surg Med Pathol   33 ( 2 )   204 - 210   2021.3

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  • Temporomandibular joint stability after two types of maxillary impaction surgery in patients with skeletal class II open bite due to condylar deformations: A preliminary study Reviewed

    Fujita K, Minamiyama S, Usumi-Fujita R, Omura S, Takasu H, Yamashita Y, Honda K, Imai H, Iwai T, Hirota M, Ono T, Mitsudo K

    Orthod Waves   80 ( 1 )   47 - 54   2021.3

  • A dermoid cyst misdiagnosed as a lipoma due to atypical magnetic resonance images: a case report Reviewed

    Mikami T, Maeda C, Aoki F, Iwai T, Yabuki Y, Okabe T, Ohashi K, Maegawa J

    J Med Case Rep   15 ( 1 )   99   2021.3

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  • Endoscopically-assisted intraoral removal of submandibular gland mucocele Reviewed

    Ideta Y, Iwai T, Sugiyama S, Ohashi N, Kitajima H, Yajima Y, Hirota M, Mitsudo K

    J Oral Maxillofac Surg Med Pathol   33 ( 2 )   161 - 164   2021.3

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  • Applicability of a single camera based catheter navigation system using teeth arch as an anatomical landmark for superselective intra-arterial infusion in advanced oral cancer treatment Reviewed

    Yanagida K, Ohya T, Wang JC, Iwai T, Izumi T, Kobayashi E, Sakuma I, Mitsudo K

    Med Biol Eng Comput   59 ( 3 )   663 - 672   2021.3

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  • Submandibular gland venous malformation with multiple phleboliths Reviewed

    Ishikawa S, Iwai T, Sugiyama S, Ohashi N, Kitajima H, Hirota M, Yamanaka S, Mitsudo K

    J Oral Maxillofac Surg Med Pathol   33 ( 2 )   183 - 187   2021.3

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  • Pleomorphic adenoma arising from heterotopic salivary gland tissue in the submandibular region Reviewed

    Iwai T, Sugiyama S, Kitajima H, Hirota M, Mitsudo K

    J Clin Diag Res   15 ( 2 )   ZJ01 - ZJ02   2021.2

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  • Delayed infection of an autopolymerizing acrylic resin implanted for orbital floor reconstruction Reviewed

    Sugiyama S, Iwai T, Mikami T, Maegawa J

    J Clin Diag Res   15 ( 1 )   ZJ01 - ZJ02   2021.1

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  • Actinomycotic osteomyelitis with proliferative periostitis arising in the mandibular ramus: an unusual case with spontaneous bone regeneration after coronoidectomy Reviewed

    Iwai T, Ohashi N, Sugiyama S, Kitajima H, Hirota M, Yamanaka S, Mitsudo K

    Oral Radiol   37 ( 1 )   137 - 145   2021.1

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  • Schwannoma arising from the sublingual glandular branch of the lingual nerve radiologically masquerading as sublingual gland tumor Reviewed

    Minamiyama S, Iwai T, Sugiyama S, Hayashi Y, Hirota M, Mitsudo K

    Oral Radiol   37 ( 1 )   125 - 129   2021.1

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    File: Minamiyama2021_Article_SchwannomaArisingFromTheSublin.pdf

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  • Endoscopically-assisted intraoral removal of submandibular gland oncocytoma Reviewed

    Sugiyama S, Iwai T, Hirota M, Mitsudo K

    J Dent Sci   16 ( 1 )   561 - 562   2021.1

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  • Endoscopically-assisted intraoral resection of compound odontoma arising from the inferomedial surface of the mandibular ramus using piezosurgery Reviewed

    Iwai T, Sugiyama S, Kitajima H, Hirota M, Mitsudo K

    J Clin Diag Res   14 ( 12 )   ZJ01 - ZJ02   2020.12

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  • Sialendoscopic removal of gold filament thread-induced sialolith in the duct of the parotid gland Reviewed

    Iwai T, Izumi T, Sugiyama S, Watanabe D, Kosugi Y, Mitsudo K

    J Stomatol Oral Maxillofac Surg   121 ( 5 )   589 - 591   2020.11

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  • Endoscopic removal of a migrated fragment of wire used for intermaxillary fixation in surgical treatment of mandibular fracture

    Iwai T, Sugiyama S, Koizumi T, Hirota M, Mitsudo K

    J Clin Diag Res   14 ( 11 )   ZJ01 - ZJ02   2020.11

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  • Computational fluid dynamics study of superselective intra-arterial chemotherapy for oral cancer: Flow simulation of anticancer agent in the linguofacial trunk Reviewed

    Kitajima H, Iwai T, Yajima Y, Mitsudo K

    Appl Sci   10 ( 21 )   7496   2020.11

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  • Image-guided removal of deeply impacted mandibular third molar using a navigation system Reviewed

    Takeda A, Iwai T, Sugiyama S, Ohashi N, Kitajima H, Yajima Y, Hirota M, Mitsudo K

    J Oral Maxillofac Surg Med Pathol   32 ( 6 )   529 - 533   2020.11

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  • Straight locking miniplate (SLM) technique achieves submillimeter accuracy of condylar positional change during bimaxillary orthognathic surgery for patients with skeletal class III malocclusion Reviewed

    Takasu H, Hirota M, Yamashita Y, Iwai T, Fujita K, Mitsudo K

    J Oral Maxillofac Surg   78 ( 10 )   1834.e1 - 1834.e9   2020.10

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  • Oral stings caused by sperm bags of squid Reviewed

    Iwai T, Sugiyama S, Kitajima H, Hirota M, Mitsudo K

    J Clin Diag Res   14 ( 10 )   ZJ01 - ZJ02   2020.10

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  • UV-mediated photofunctionalization of dental implant: A seven-year results of a prospective study Reviewed

    Hirota M, Ozawa T, Iwai T, Mitsudo K, Ogawa T

    J Clin Med   9 ( 9 )   E2733   2020.9

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  • Response to the comments on ‘Effectiveness of subspinal Le Fort I osteotomy in preventing postoperative nasal deformation' Reviewed

    Yamashita Y, Iwai T, Honda K, Fujita K, Imaai H, Takasu H, Omura S, Hirota M, Mitsudo K

    J Plast Reconstr Aesthet Surg   73 ( 9 )   1783   2020.9

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  • Accuracy of mandible-independent maxillary repositioning using pre-bent locking plates: a pilot study Reviewed

    Imai H, Fujita K, Yamashita Y, Yajima Y, Takasu H, Takeda A, Honda K, Iwai T, Mitsudo K, Omura S

    Int J Oral Maxillofac Surg   49 ( 7 )   901 - 907   2020.7

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    File: 1-s2.0-S0901502719314110-main.pdf

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  • Effectiveness of subspinal Le Fort I osteotomy in preventing postoperative nasal deformation Reviewed

    Yamashita Y, Iwai T, Honda K, Fujita K, Imai H, Takasu H, Omura S, Hirota M, Mitsudo K

    J Plast Reconstr Aesthet Surg   73 ( 7 )   1326 - 1330   2020.7

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  • A nitrogen-containing bisphosphonate inhibits osteoblast attachment and osteoconductivity of bone compatible porous scaffold Reviewed

    Koyama C, Hirota M, Okamoto Y, Iwai T, Ogawa T, Hayakawa T, Mitsudo K

    J Mech Behav Biomed Mater   104   103635   2020.4

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  • Sentinel lymph node biopsy with preoperative CT lymphography and intraoperative indocyanine green fluorescence imaging for N0 early tongue cancer: A long-term follow-up study Reviewed

    Ishiguro K, Iwai T, Izumi T, Sugiyama S, Baba J, Oguri S, Hirota M, Mitsudo K

    J Craniomaxillofac Surg   48 ( 3 )   217 - 222   2020.3

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    File: 1-s2.0-S1010518220300159-main.pdf

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  • Computational fluid simulation of fibrinogen around dental implant surfaces Reviewed

    Kitajima H, Hirota M, Iwai T, Hamajima K, Ozawa R, Hayashi Y, Yajima Y, Iida M, Koizumi T, Kioi M, Mitsudo K, Ogawa T

    Int J Mol Sci   21 ( 2 )   E660   2020.1

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    File: ijms-21-00660.pdf

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  • CT lymphography for sentinel lymph node mapping of clinically N0 early oral cancer Reviewed

    SugiyamaS, Iwai T, Izumi T, Ishiguro K, Baba J, Oguri S, Mitsudo K

    Cancer Imaging   19 ( 1 )   72   2019.11

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  • Intra-oral minor salivary gland tumors: A pathological study of 131 cases in the Japanese population Reviewed

    Hayashi Y, Iwai T, Sugiyama S, Osawa K, Yoshi H, Minamiyama S, Kitajima H, Hirota M, Mitsudo K

    J Oral Maxillofac Surg Med Pathol   31 ( 6 )   424 - 427   2019.11

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  • Swallowing function of advanced tongue cancer patients before and after bilateral neck dissection following superselective intra-arterial chemoradiotherapy for organ preservation: a case-control study Reviewed

    Ohashi N, Iwai T, Tohara H, Chiba Y, Oguri S, Koizumi T, Mitsudo K, Tohnai I

    Oral Radiol   35 ( 3 )   230 - 238   2019.9

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  • Complications of minimally invasive tibial bone harvesting: Risk factors and treatment Reviewed

    Hirota M, Iwai T, Ozawa T, Mizuki N, Tohnai I

    Int J Oral Maxillofac Implants   34 ( 4 )   987 - 991   2019.7

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  • Hemangiopericytoma/solitary fibrous tumor of the buccal mucosa: A case report Reviewed

    Minamiyama S, Udaka N, Iwai T, Hirota M, Ozawa T, Mitsudo K

    J Oral Maxillofac Surg Med Pathol   31 ( 4 )   269 - 271   2019.7

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  • Prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma treated by intra-arterial infusion chemotherapy concurrent with radiotherapy Reviewed

    Hayashi Y, Osawa K, Nakakaji R, Minamiyama S, Ohashi N, Ohya T, Iida M, Iwai T, Ozawa T, Oguri S, Koizumi T, Hirota M, Kioi M, Hata M, Mitsudo K

    Head Neck   41 ( 6 )   1777 - 1784   2019.6

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  • Pathological changes in the lymphatic system of patients with secondary upper limb lymphoedema. Reviewed

    9 ( 1 )   8499   2019.6

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    DOI: 10.1038/s41598-019-44735-w

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  • Retrograde superselective intra-arterial chemoradiotherapy for squamous cell carcinoma of the buccal mucosa Reviewed

    Koizumi T, Minamiyama S, Hayashi Y, Osawa K, Ohashi N, Ohya T, Iida M, Iwai T, Oguri S, Hirota M, Kioi M, Mitsudo K

    Int J Radiat Res   17 ( 2 )   283 - 291   2019.4

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  • Thermochemoradiotherapy using superselective intra-arterial infusion for patients with oral cancer with cervical lymph node metastases. Reviewed International journal

    Nozato T, Koizumi T, Hayashi Y, Iida M, Iwai T, Oguri S, Hirota M, Kioi M, Koike I, Hata M, Tohnai I, Mitsudo K

    Anticancer Res   39 ( 3 )   1365 - 1373   2019.3

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    AIM: We aimed to retrospectively investigate the outcomes and pathological effects of retrograde superselective intra-arterial chemoradiotherapy (IACRT) combined with hyperthermia on metastatic lymph nodes of patients with oral squamous cell carcinoma. PATIENTS AND METHODS: Patients with lymph node metastasis from oral cancer were treated with IACRT using cisplatin plus docetaxel combined with hyperthermia prior to surgical removal 8 weeks after completion of IACRT and hyperthermia. The locoregional control and overall survival rates were calculated using the Kaplan-Meier method. RESULTS: A total of 35 patients received the combination therapy of whom 26 received it as definitive treatment and in the rest, it was administered as preoperative treatment. The 5-year locoregional control and overall survivaI rates were 95.6% and 80.2% in the definitive-treatment group, and 100% and 66.6% in the preoperative-treatment group, respectively. CONCLUSION: The combination therapy provided good outcomes in patients with lymph node metastases from advanced oral cancer.

    DOI: 10.21873/anticanres.13250

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  • Retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia and cetuximab for carcinoma of the buccal mucosa with N3 lymph node metastasis: a case report. Reviewed

    Sakuma K, Koizumi T, Mitsudo K, Ueda J, Hayashi Y, Iwai T, Hirota M, Kioi M, Yoshii H, Kaizu H, Hata M, Tanaka A, Tohnai I

    Oral Radiol   35 ( 1 )   77 - 83   2019.1

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    We herein report a case of squamous cell carcinoma of the buccal mucosa with N3 cervical lymph node metastasis in a 63-year-old man. The patient was treated with combination therapy comprising radiotherapy (2 Gy/day, total of 70 Gy), superselective intra-arterial chemotherapy via a superficial temporal artery (docetaxel, total of 70 mg/m2 and cisplatin, total of 175 mg/m2), cetuximab (initial dose of 400 mg/m2 with subsequent weekly doses of 250 mg/m2 intravenously), and four sessions of hyperthermia for cervical lymph node metastases. The patient responded well to the therapy, with a complete response of the primary tumor. Radical neck dissection was performed with reconstructive surgery, including resection of the overlying skin. A pathologic complete response was achieved for the N3 and all other cervical lymph node metastases. The patient showed no evidence of recurrence in the 3 years following treatment. Based on the findings in the present case, the use of retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia and cetuximab seems to be a promising modality for patients with N3 cervical lymph node metastasis of oral cancer.

    File: Sakuma2019_Article_RetrogradeSuperselectiveIntra-.pdf

    DOI: 10.1007/s11282-018-0319-y

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  • Ultrasound-guided extraoral removal of extraparenchymal sialoliths caused by acute parotitis Reviewed

    Iwai T, Sugiyama S, Hayashi Y, Hirota M, Mitsudo K

    J Clin Diagn Res   13 ( 1 )   ZD17 - ZD18   2019.1

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  • Daily concurrent chemoradiotherapy using retrograde superselective intra-arterial infusion for locally advanced squamous cell carsinoma of the mandibular gingiva Reviewed

    Oguri S, Mitsudo K, Iida M, Iwai T, Koizumi T, Hirota M, Kioi M, Koike I, Hata M, Tohnai I

    J Oral Maxillofac Surg Med Pathol   30 ( 6 )   483 - 487   2018.11

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  • Airway obstruction caused by pharyngolaryngeal swelling after intraoral removal of a submandibular gland stone. Reviewed International journal

    Satomi Sugiyama, Toshinori Iwai, Nobuhide Ohashi, Senri Oguri, Makoto Hirota, Kenji Mitsudo

    Therapeutics and clinical risk management   14   2323 - 2325   2018.11

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    Intraoral removal of a submandibular gland stone is less invasive than submandibulectomy, with no life-threatening airway complications reported until now. We report a case involving airway obstruction caused by pharyngolaryngeal swelling after intraoral removal of a submandibular gland stone. A 31-year-old man with a left submandibular gland stone underwent intraoral removal of the stone under general anesthesia and was discharged 1 day after surgery. That night, he was transported back to our hospital by ambulance for dyspnea. Because computed tomography showed pharyngolaryngeal swelling, he was intubated and managed by a ventilator. Four days later, the pharyngolaryngeal swelling had mostly resolved and he was extubated and discharged. Surgeons should be vigilant of the potential risk of airway complications following an intraoral approach for submandibular gland stone removal.

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  • Multidisciplinary approach for treatment of a dentigerous cyst - marsupialization, orthodontic treatment, and implant placement: a case report Reviewed

    Aoki N, Ise K, Inoue A, Kosugi Y, Koyama C, Iida M, Baba J, Iwai T, Mitsudo K

    J Med Case Rep   12 ( 1 )   305   2018.10

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  • Lateral bone window approach with Micross Mini Bone Scraper for sinus floor elevation Reviewed

    Aoki N, Baba J, Iwai T, Tohnai I

    J Maxillofac Oral Surg   17 ( 3 )   291 - 295   2018.9

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  • Daily cisplatin and weekly docetaxel versus weekly cisplatin intra-arterial chemoradiotherapy for late T2-3 tongue cancer: a pilot and feasibility trial Reviewed

    Hayashi Y, Minamiyama S, Ohya T, Iida M, Iwai T, Koizumi T, Oguri S, Hirota M, Kioi M, Hata M, Taguri M, Mitsudo K

    Medicina (Kaunas)   54 ( 4 )   52   2018.9

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  • Effect of photofunctionalization on early implant failure Reviewed

    Hirota M, Ozawa T, Iwai T, Ogawa T, Tohnai I

    Int J Oral Maxillofac Implants   33 ( 5 )   1098 - 1102   2018.9

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  • Solitary compact osteoma of the inferior border of the mandible protruded in the anterior belly of the digastric muscle Reviewed

    Ito K, Iwai T, Eda T, Takahashi K, Kondoh T, Goss AN

    J Oral Maxillofac Surg Med Pathol   30 ( 4 )   350 - 352   2018.7

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  • Role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in predicting pathological response to preoperative super-selective intra-arterial chemoradiotherapy for advanced squamous cell carcinoma of the mandible. Reviewed International journal

    Shibasaki M, Iwai T, Oguri S, Koizumi T, Hirota M, Mitsudo K, Ozawa Y, Tohnai I

    J Bone Oncol   11   33 - 37   2018.6

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    Introduction: Although chemoradiotherapy (CRT) for oral squamous cell carcinoma (SCC) has been shown to preserve organ function and improve cosmetic results, site-specific data, especially mandible, are limited. The aim of this study was to evaluate the predictability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) on response to super-selective intra-arterial CRT for advanced SCC of the mandible. Methods: Fifteen patients with advanced SCC of the mandible underwent super-selective intra-arterial CRT followed by radical resection. Maximum standardized uptake value (SUVmax) of the mandibular lesion was evaluated with FDG-PET/CT before and after CRT. The SUVmax before and after CRT was defined as pre-SUVmax and post-SUVmax, respectively. The difference between pre- and post-SUVmax was calculated as SUVmax reduction rate to evaluate treatment response of the mandibular lesion. Each SUVmax reduction rate and surgical specimen of the corresponding lesion was analyzed to evaluate an accuracy of the modality for predicting pathological response. Results: The median of pre-SUVmax was significantly lower than that of post-SUVmax (p = 0.001). Of the 15 patients, 6 had a pathological complete response (pCR) and 9 had a non-pCR. Neither pCR patients nor non-pCR patients showed significant difference of the median of SUVmax between pre- and post-CRT (pre-CRT p = 0.099 post-CRT p =0.074). The SUVmax reduction rate in patients with pCR was significantly higher than that with non-pCR (p = 0.002). Receiver operating characteristic analysis revealed that the optimal cut-off point of the reduction rate was 64.7%, with 83% sensitivity and 100% specificity. Conclusions: These results concluded that SUVmax reduction rate can predict pathological complete response of preoperative super-selective intra-arterial CRT for advanced SCC of the mandible.

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  • Accidental displacement of mandibular third molar root into the sublingual space and delayed removal Reviewed

    Yamashita Y, Iwai T, Oaki S, Aoki N, Tohnai I

    Oral Surg   11 ( 2 )   153 - 156   2018.5

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    Oral surgeons rarely experience accidental displacement of a mandibular impacted third molar into adjacent anatomical spaces as a complication. As any displaced third molar or its root is commonly removed at the time of displacement or within several weeks of the extraction, delayed removal several years after initial extraction is extremely rare. We report here accidental displacement of a mandibular third molar root into the sublingual space and a 5-year delay in its removal. A 42-year-old woman presented to our department with pain and swelling in the lingual aspect of the left mandible. Computed tomography revealed a 15 × 11 × 9 mm lesion, with a similar density to that of the surrounding bone and involving the lingual cortex of the left mandible. A yellowish-white hard tissue lesion was protruding from the lingual mucosa of the left mandibular ramus. The patient had undergone removal of a left impacted mandibular third molar at a private dental clinic 5 years earlier and we diagnosed the lesion as a remnant third molar root. The patient had not been informed by her dentist of accidental displacement of the tooth into the sublingual space after crown removal. After complete alleviation of inflammation, the patient underwent intraoral removal of the root under general anaesthesia. After elevating the lingual mucoperiosteal flap from the mandibular ramus to the premolar region, the root was easily removed using an elevator and forceps. Her postoperative course was uneventful and there were no complications such as lingual nerve injury.

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    DOI: 10.1111/ors.12303

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  • Peripheral osteoma arising from the lateral surface of the mandibular ramus Reviewed

    Osawa K, Iwai T, Sugiyama S, Kitajima H, Baba J, Oguri S, Hirota M, Tohnai I

    J Oral Maxillofac Surg Med Pathol   30 ( 3 )   278 - 280   2018.5

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    Osteomas are benign, slow-growing osteogenic tumors that consist of compact or cancellous bone. They sometimes arise from the craniomaxillofacial region. Among the peripheral, central, and extraskeletal types, peripheral osteomas arise from the periosteum, usually as unilateral, pedunculated, mushroom-like masses. Here, we report an unusual peripheral osteoma arising from the lateral surface of the mandibular ramus. A 57-year-old woman with a mass at the left mandibular ramus was referred to us. The hard and immobile mass had been growing for 15 years, and she had facial asymmetry. She had no trismus, temporomandibular joint dysfunction, previous facial trauma, or infection. Computed tomography showed a mushroom-like lesion (21.1 × 13.4 × 13.1 mm) arising from the lateral surface of the left mandibular ramus. Clinical diagnosis was peripheral osteoma. The lesion was removed using rotary instruments and a chisel through an intraoral approach under general anesthesia. The lesion had intruded into the masseter muscle. Pathological diagnosis was compact osteoma. The postoperative course was uneventful and there has been no recurrence 1.5 years after surgery.

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    DOI: 10.1016/j.ajoms.2018.02.004

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  • Orthognathic surgery and implant-supported bridge in a Class III patient injured in a motor vehicle accident Reviewed

    Honda K, Hirota M, Iwai T, Fujita K, Ono T, Omura S, Tohnai I

    J Craniofac Surg   29 ( 3 )   e296 - e298   2018.5

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  • Chemoradiotherapy using retrograde superselective intra-arterial infusion for tongue cancer: Analysis of therapeutic results in 118 cases. Reviewed International journal

    Mitsudo K, Hayashi Y, Minamiyama S, Ohashi N, Iida M, Iwai T, Oguri S, Koizumi T, Kioi M, Hirota M, Koike I, Hata M, Tohnai I

    Oral Oncol   79   71 - 77   2018.4

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    OBJECTIVES: To evaluate the therapeutic results and rate of organ preservation in patients with squamous cell carcinoma of the tongue treated with retrograde superselective intra-arterial chemoradiotherapy. MATERIALS AND METHODS: Between June 2006 and June 2015, 118 patients with tongue cancer were treated with intra-arterial chemoradiotherapy. Treatment consisted of radiotherapy (total 50-70 Gy) and daily concurrent intra-arterial chemotherapy (docetaxel, total 50-70 mg/m2; cisplatin, total 125-175 mg/m2) for 5-7 weeks. Locoregional control and overall survival rates were calculated by the Kaplan-Meier method. Cox's proportional hazards model was used for both univariate and multivariate analyses. RESULTS: The median follow-up for all patients was 38.5 months (range, 3-129 months). After intra-arterial chemoradiotherapy, primary site complete response was achieved in 113 (95.8%) of 118 cases. Three-year locoregional control and overall survival rates were 80.3% and 81.5%, respectively. Grade 3 or 4 toxicities included neutropenia in 16.1% and mucositis in 87.3%. Grade 3 toxicities included anemia in 12.7%, thrombocytopenia in 3.4%, nausea/vomiting in 3.4%, dermatitis in 45.7%, dysphagia in 74.6%, and fever in 2.5% of patients. Late toxicity consisting of grade 3 osteoradionecrosis of the jaw occurred in 4.2% of patients. On univariate analysis, T stage and overall stage were significantly associated with locoregional control, and N stage and overall stage were significantly associated with overall survival. On multivariate analysis, the only significant predictor of overall survival was overall stage classification. CONCLUSION: Retrograde superselective intra-arterial chemoradiotherapy for tongue cancer provided good overall survival and locoregional control.

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  • Sialendoscopic removal of fish bone-induced sialoliths in the duct of the submandibular gland. Reviewed International journal

    Auris, nasus, larynx   45 ( 2 )   343 - 345   2018.4

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    Obstructive sialadenitis of the submandibular gland is commonly caused by sialoliths, but more rarely by foreign body-induced sialoliths. Here, we report minimally invasive sialendoscopic removal of fish bone-induced sialoliths in the duct of the submandibular gland. A 43-year-old woman presented with recurrent swelling of the right submandibular gland at other hospital. Computed tomography (CT) showed an 8-mm linear calcification in the posterior part of Wharton's duct. The lesion was deemed difficult to remove and she was followed up. However, because the lesion did not resolve spontaneously within 9 months and chronic sialadenitis symptoms persisted, she was referred to our department for endoscopic removal. CT showed a linear calcification (5.6×1.2×0.8mm) connecting 2 spherical calcifications (2.3×2.1×1.9mm; 1.8×1.4×1.1mm) in the anterior part of Wharton's duct. The patient underwent endoscopic removal of the lesion using a 1.6-mm-diameter sialendoscope under local anesthesia. The specimen contained a fish bone connecting 2 sialoliths. The patient was unaware of the fish-bone injury. After removal, there was no recurrence of submandibular gland swelling during 6 months follow-up.

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    DOI: 10.1016/j.anl.2017.03.010

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  • The holographic human for surgical navigation using Microsoft HoloLens Reviewed

    Itamiya T, Iwai T, Kaneko T

    EPiC Ser Eng   1   26 - 30   2018.2

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  • Evaluation of influence factors to reduce mechanical stress on the marginally resected mandibular bone against dental implant-supported occlusion Reviewed

    Tamai N, Hirota M, Iwai T, kioi M, Mitsudo K, Tohnai I

    J Hard Tissue Biol   27 ( 1 )   11 - 16   2018

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    This study aimed to evaluate the mechanical stress on resected mandibular bone against occlusal force using dental implant without any bone grafting by finite element analysis to reduce the risk of the bone fracture. A model of marginal resection of the symphysis of the mandible, in which the bone height of the region was 5, 10 or 15 mm, was prepared. Two, four, or six implant-supported fixed prostheses (superstructure) or overdenture were set up in the model and loaded with 500N of occlusal force. The von Mises stress on the resected region was the highest when two implants were bilaterally placed at positions closest to the resected region. The von Mises stress value on the resected region could be high enough to induce the bone fracture. The mechanical stress was reduced up to &lt
    50 % by adding implant at posterior position and connecting all implants. The presence of superstructure on 4 or 6 implants significantly decreased the von Mises stress when the residual bone height was 10 or 15 mm. Use of 6 implants showed no significant advantage at the stress reduction compared to use of 4 implants. When the residual bone height was 5 mm, reinforcement of the residual bone or bone graft should be considered to avoid the bone fracture. Although the present results were obtained under restrictive conditions, the number of implant, implant position, and prostheses style could reduce the von Mises stress and the risk of bone fracture on the resected region.

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  • Significance of the lateral thoracic artery in pectoralis major musculocutaneous flap reconstruction quantitative assessment of blood circulation using indocyanine green angiography Reviewed

    Miyazaki H, Igari K, Kudo T, Iwai T, Wada Y, Takahashi Y, Inoue Y, Asamura S

    Ann Plast Surg   79 ( 5 )   498 - 504   2017.11

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    Free tissue transfer is the preferred reconstruction option inmost major head and neck reconstructions. The pectoralis major muscle musculocutaneous (PMMC) flap is commonly used in salvage of necrotic free flaps and is the first choice for patients who are not candidates for free flaps. The lateral thoracic artery (LTA), which is thought to contribute to blood perfusion of the inferior and lateral mammary area, is not preserved in a conventionally harvested PMMC flap. With regard to blood supply, it has been suggested that the LTA should be preserved, in addition to the pectoral branch of the thoracoacromial artery, when a skin island is designed in the lower chest to attain a pedicle length sufficient for head and neck reconstruction. However, an effect on hemodynamic improvement using the LTA has not been shown quantitatively. In this study, we examined 8 patients with oral cancer who underwent reconstruction procedures with a bipedicle PMMC flap that included the LTA, in addition to the thoracoacromial artery. Intraoperative indocyanine green angiography was performed to examine circulation to the PMMC flap with or without LTA clamping after harvesting. After image processing, data were analyzed using a new quantitative perfusion assessment system with parameters that we recently established for assessment of peripheral arterial disease of the lower limbs. All patients had good clinical courses with whole-flap survival, no vascular insufficiency of the skin island, and no fistula formation. Intraoperative indocyanine green angiography showed an increased inflow rate into the skin island in an LTA-declamped condition in all cases, implying that the preserved LTA increased the blood supply to skin islands in the pectoralis major muscle. We conclude that preserving the LTA in a PMMC flap can increase blood perfusion and stabilize the vascularity of the flap, making the reconstruction more effective and reliable than with use of a conventionally harvested flap. Therefore, it is worthwhile to preserve the LTA as a major contributor to a lateral and distal PMMC flap.

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    DOI: 10.1097/SAP.0000000000001123

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  • Empty fenestration of the external jugular vein: A rare variant Reviewed

    Sugiyama S, Iwai T, Tohnai I

    J Anat Soc India   66 ( Supplement 2 )   S1 - S3   2017.10

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    The external jugular vein (EJV) is often utilized as a recipient vein in the head and neck during microsurgical reconstruction or for central venous catheterization. However, there are few studies about its anatomical variations. Knowledge of these variations is important for clinicians as well as surgeons. We report here an empty fenestration of the EJV, an extremely rare variant, observed during modified radical neck dissection. (C) 2017 Anatomical Society of India. Published by Elsevier, a division of RELX India, Pvt. Ltd. All rights reserved.

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  • Pathological fracture successfully treated with simple orthodontic appliance, chin cup after cyst removal Reviewed

    Aoki N, Inoue A, Kosugi Y, Koyama C, Iida M, Iwai T, Tohnai I

    J Dent Oral Disord Ther   5 ( 4 )   1 - 4   2017.10

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  • A modified method for simple dilatation of the duct orifice in sialendoscopy Reviewed

    Sakuma K, Iwai T, Sugiyama S, Hayashi, Y, Ueda J, Oguri S, Tohnai I

    J Oral Maxillofac Surg Med Pathol   29 ( 5 )   420 - 421   2017.9

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    Objective As the first step in sialendoscopy, the orifice of the salivary duct is progressively dilated using different sized salivary probes before the sialendoscope is inserted. However, the procedure can be challenging as surgeons may lose the duct orifice and find it difficult to re-identify after each probe change. To overcome this problem, we previously reported a simple technique using a guidewire, but a more cost-effective and time-saving approach is needed. We describe a modified method for simple dilatation of the papilla orifice to introduce the sialendoscope easily into the ductal lumen. Methods A 24 G angiocatheter and a 0.5-mm-diameter salivary or lacrimal probe is prepared preoperatively. The tip of the angiocatheter (3.3–0.7 mm outer diameter) is cut and the probe is threaded into the tapered catheter. On identifying the duct orifice by pressing the salivary gland, they are inserted together into the duct orifice. Only the catheter is advanced into the duct along the probe to dilate the orifice. The orifice can be easily dilated without losing the papilla entrance. After removing the catheter, a sialoendoscope can be inserted easily into the duct. Results We performed more than 100 procedures using this modified method and the sialendoscope could be inserted into the duct within 10 s after probe insertion into the orifice. Conclusion This method offers simple dilatation of the papilla orifice to introduce the sialendoscope.

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    DOI: 10.1016/j.ajoms.2017.05.003

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  • A simple self-made scale to design surgical margin in tongue cancer: Technical note Reviewed

    Aoki N, Inoue A, Kosugi Y, Koyama C, Iida M, Iwai T, Tohnai I

    POJ Dent Oral Care   1 ( 2 )   1 - 3   2017.9

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  • Bilateral idiopathic aneurysms of the lingual artery identified by three-dimensional computed tomography angiography Reviewed

    Iwai T, Izumi T, Hayashi Y, Oguri S, Koizumi K, Mitsudo K, Tohnai I

    Oral Radiol   33 ( 3 )   227 - 230   2017.9

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    Aneurysms of the external carotid artery and its branches are rare, and usually occur in the more superficial branches. Lingual artery (LA) aneurysms are particularly rare, and pseudoaneurysms are associated with trauma, infection, and surgical intervention. Only a few cases of idiopathic LA aneurysms have been reported in the English literature. LA aneurysms can be fatal if they are not recognized and treated. Here, we report a case of bilateral idiopathic aneurysms of the LA identified by three-dimensional (3D) computed tomography angiography (CTA). An 80-year-old man with right tongue cancer (T2N0M0) and left tongue leukoplakia was referred to our department for treatment. He had no previous history of trauma, infection, surgery, or aneurysm in the oral and maxillofacial region. CTA with 3D reconstruction showed right and left aneurysms of the LA, with sizes of 2.4 x 2.3 x 2.1 mm and 3.4 x 3.2 x 2.5 mm, respectively. The patient underwent bilateral partial glossectomy under general anesthesia without intervention for the aneurysms, and the post-operative course was uneventful. A radiological follow-up has been performed regularly for the small unruptured aneurysms.

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  • Deltopectoral flap revisited for reconstruction surgery in patients with advanced thyroid cancer: a case report Reviewed

    Mikami M, Kagimoto S, Yabuki Y, Yasumura K, Iwai T, Maegawa J, Suganuma N, Hirakawa S, Masudo K

    BMC Surg   17   101   2017.9

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    Background: We present the cases of 2 patients with invasive thyroid cancer, who underwent reconstructive surgery using a deltopectoral flap. Although the overall rate of extrathyroidal extension in patients with thyroid cancer is quite low, skin invasion is the most common pattern observed. Reconstructive surgery, involving local skin flaps, is required in these patients. The deltopectoral flap relies on the blood supply from intercostal perforators of the internal thoracic artery and usually requires skin grafting to the donor site. The internal thoracic artery is rarely sacrificed in these cases, even in an advanced surgery such as in patients with invasive thyroid cancer.
    Case presentation: A 55-year-old man with a distended thyroid gland presented to our hospital. He underwent advanced surgery, including skin excision, because we suspected that his tumor was thyroid cancer. The defect was covered with an ipsilateral deltopectoral flap via transposition of the flap, without skin grafting. In the second case, a 67-year-old woman with thyroid cancer that metastasized to her neck lymph nodes presented to our institution. Although the ipsilateral internal thoracic artery was sacrificed near its origin during tumor resection, the deltopectoral flap was raised in the usual manner without any complications. The skin defect caused by the tumor resection was covered with the flap. The patient had an uneventful clinical course for more than 2 years of follow-up. These 2 cases show the effectiveness of using the deltopectoral flap as a reconstructive option for patients with thyroid cancer who underwent radical surgery, resulting in a skin defect. The first case shows that this flap does not always require skin grafting to the donor site. To our knowledge, the second case may be the first report of a deltopectoral flap that was safely raised and applied with resection of the bifurcation of the ipsilateral internal thoracic artery.
    Conclusions: Although thyroid cancer surgery with surrounding skin excision is a rare procedure, we found that the deltopectoral flap was useful and should be the first choice for patients undergoing reconstructive surgery, whether the bifurcation of the ipsilateral internal thoracic artery is sacrificed.

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  • Giant sialolith of the submandibular gland Reviewed

    Iwai T, Izumi T, Ohya T, Oguri S, Tohnai I

    J Clin Diagn Res   11 ( 8 )   ZJ03 - ZJ04   2017.8

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  • Implant treatment for the patients with severe deep bite using screwed denture: technical note Reviewed

    Aoki N, Inoue A, Kosugi Y, Koyama C, Iida M, Iwai T, Tohnai I

    POJ Dent Oral Care   1 ( 1 )   1 - 4   2017.8

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  • Use of a novel tongue retractor for intraoral removal of proximal/hilar submandibular gland stone Reviewed

    Oguri S, Iwai T, Ueda J, Tohnai I

    J Oral Maxillofac Surg Med Pathol   29 ( 4 )   306 - 308   2017.7

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    Objective Intraoral removal of proximal/hilar or intraglandular stones is technically difficult, because the surgical field is limited. However, intraoral removal of deep submandibular gland stones has several advantages over submandibular sialoadenectomy, including shorter operation time and better gland function. To overcome the technical difficulties associated with intraoral removal of deep submandibular gland stones, we designed a novel tongue retractor and here describe its use. Methods The tongue retractor for the intraoral removal of proximal/hilar submandibular gland stones has a wing on each side for the retraction of soft tissues. After careful dissection along Wharton's duct to the hilum of the submandibular gland, we used the new tongue retractor. Results The new tongue retractor enables the lingual soft tissues to be retracted easily and it maintains a better surgical field, compared with standard tongue retractors. For hilar/intraglandular stones in the medial portion of the submandibular gland, after dissection of the medial side of the gland, the newly designed tongue retractor provided a good surgical field for easy and reliable stone removal. Conclusion This novel tongue retractor offers a better surgical field and shorter operation time for intraoral stone removal than standard tongue retractors.

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  • Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for T2-4N0 tongue cancer: control of occult neck metastasis Reviewed

    Minamiyama S, Mitsudo K, Hayashi Y, Iida M, Iwai T, Nakashima H, Oguri S, Ozawa T, Koizumi T, Hirota M, Kioi M, Tohnai I

    Oral Surg Oral Med Oral Med Oral Radiol   124 ( 1 )   16 - 23   2017.7

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    Objective. To evaluate the therapeutic results and control of occult neck metastasis in patients with T2-4N0 oral tongue squamous cell carcinoma treated with retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy.
    Study Design. Forty-two patients with T2-4N0 tongue cancer (17 with late T2; 13 with T3; and 12 with T4a disease, M0) were treated with intra-arterial chemoradiotherapy. Treatment consisted of retrograde superselective intra-arterial chemotherapy (docetaxel 50-70 mg/m(2), cisplatin 125-175 mg/m(2)) and daily concurrent radiotherapy (50-70 Gy) for 5-7 weeks.
    Results. The median follow-up for all patients was 46.5 months (range, 8-105 months). Primary-site complete response was achieved in 42 of 42 cases (100%). Three-year overall survival, progression-free survival, and local control rates were 85.0%, 77.8%, and 91.7%, respectively. Delayed neck metastasis was detected in 5 of 42 cases (11.9%). Grade 3 or 4 toxic changes included oral mucositis in 92.9%, neutropenia in 21.4%, and thrombocytopenia in 4.8%. Grade 3 toxicities included anemia in 16.7%, radiation dermatitis in 9.5%, nausea in 4.8%, and fever in 2.4%.
    Conclusions. Retrograde superselective intra-arterial chemotherapy for T2-4N0 tongue cancer provided good overall survival and local control rates and was effective for occult neck metastasis.

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  • Clinical outcomes of retrograde intraarterial chemotherapy concurrent with radiotherapy for elderly oral squamous cell carcinoma patients aged over 80 years old Reviewed

    RADIATION ONCOLOGY   12 ( 1 )   112   2017.7

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    Background: The aim of this retrospective observational study was to evaluate toxicities, overall survival, and locoregional control in elderly oral squamous cell carcinoma patients who had undergone retrograde intra-arterial chemotherapy combined with radiotherapy.
    Methods: Thirty-one elderly patients over 80 years old with oral squamous cell carcinoma were enrolled in present study. The treatment schedule consisted of intra-arterial chemotherapy (docetaxel, total 60 mg/m(2); cisplatin, total 150 mg/m2) and daily concurrent radiotherapy (total, 60 Gy) for 6 weeks.
    Results: The median patient age was 82.5 years old (range, 80-88 years). Of the 31 patients, six (19%) had stage II, 6 (19%) had stage III, 17 (55%) had stage IVA, and 2 (6%) had stage IVB. The median follow-up period for all patients was 37 months (range, 7-86 months). The 3-year overall survival and locoregional control rates were 78% and 81%, respectively. The major acute grade 3 adverse events were oral mucositis in 22 (71%) patients, neutropenia in 16 (52%), and dermatitis in 11 (35%). With respect to late toxicities, 1 patient (3%) developed grade 3 osteoradionecrosis of the jaw. No grade 4 or higher toxicities were observed during the treatment and follow-up periods.
    Conclusions: Retrograde intra-arterial chemotherapy combined with radiotherapy was effective in improving overall survival and locoregional control even for elderly patients.

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  • Computational fluid dynamics study of the pharyngeal airway space before and after mandibular setback surgery in patients with mandibular prognathism Reviewed

    Yajima Y, Oshima M, Iwai T, Kitajima H, Omura S, Tohnai I

    Int J Oral Maxillofac Surg   46 ( 7 )   839 - 844   2017.7

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    The purpose of this study was to investigate the relationship between the pressure drop in the pharyngeal airway space (Delta P-PAS) and the minimum cross-sectional area (minCSA) of the pharyngeal airway before and after mandibular setback surgery using computational fluid dynamics, in order to prevent iatrogenic obstructive sleep apnoea. Eleven patients with mandibular prognathism underwent bilateral sagittal split osteotomy for mandibular setback. Three-dimensional models of the upper airway were reconstructed from preoperative and postoperative computed tomography images, and simulations were performed using computational fluid dynamics. Delta P-PAS and the minCSA of the pharyngeal airway were calculated, and the relationship between them was evaluated by non-linear regression analysis. In all cases, the minCSA was found at the level of the velopharynx. After surgery, Delta P-PAS increased significantly and the minCSA decreased significantly. The non-linear regression equation expressing the relationship between these variables was Delta P-PAS = 3.73 x minCSA(-2.06). When the minCSA was <1 cm(2), Delta P-PAS increased greatly. The results of this study suggest that surgeons should consider bimaxillary orthognathic surgery rather than mandibular setback surgery to prevent the development of iatrogenic obstructive sleep apnoea when correcting a skeletal class III malocclusion.

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  • Occipital artery arising from the superior aspect of the carotid bifurcation identified by three-dimensional computed tomography angiography Reviewed

    Iwai T, Izumi T, Tohnai I

    J Anat Soc India   66 ( 1 )   75 - 77   2017.6

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    Variation of the branches of the external carotid artery is well known, but it is extremely rare for the occipital artery (OA) to arise from the carotid bifurcation (CB). A 73-year-old man was found to have this anatomical variation on the right side by three-dimensional CT angiography for vascular mapping of the carotid arteries before superselective intra-arterial catheterization. The OA arose from the CB and the inner diameter of the origin of the OA was 1.5 mm. The CB was located at the level of C3-C4 and 7.9 mm above the tip of the greater horn of the hyoid bone. (C) 2017 Anatomical Society of India. Published by Elsevier, a division of RELX India, Pvt. Ltd. All rights reserved.

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  • Facial nerve paralysis after super-selective intra-arterial chemotherapy for oral cancer Reviewed

    Sugiyama S, Iwai T, Oguri S, Koizumi T, Mitsudo K, Tohnai I

    Int J Oral Maxillofac Surg   46 ( 6 )   682 - 686   2017.6

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    Facial nerve paralysis (FNP) after super-selective intra-arterial chemotherapy (SSIAC) is a relatively rare local side effect of SSIAC to the maxillary artery (MA) or the middle meningeal artery (MMA). The incidence and prognosis of FNP after SSIAC in 381 patients with oral cancer (133 with catheterization of the MA, 248 without) was investigated retrospectively. Only three patients (two male and one female) had FNP, for an incidence of 0.8%. All patients with FNP had undergone catheterization of the MA, and the incidence of FNP in this group was 2.3% (3/133). One of the three patients with FNP had paralysis of the third branch of the trigeminal nerve. FNP occurred a mean of 8.7 days (range 5-11 days) after initial SSIAC, and the mean total dose of cisplatin was 55.8 mg (range 42.5-67.2 mg) and of docetaxel was 25.4 mg (range 17.0-33.6 mg). FNP resolved completely a mean of 12.7 months (range 6-19 months) after onset. Because the administration of anticancer agents via the MA or MMA carries a risk of FNP, this information will be useful when obtaining informed consent from patients before treatment.

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  • Actinomyces-associated calcifications around an impacted third molar of the mandible Reviewed

    Shibasaki M, Iwai T, Chikumaru H, Hirota M, Mitsudo K, Hibiya T, Ohashi K, Tohnai I

    J Oral Maxillofac Surg Med Pathol   29 ( 3 )   245 - 248   2017.5

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    Actinomycosis is often considered an affliction of the soft tissues, but in fact, the process spreads to bone in up to 15% of cases. Although Actinomyces-associated lesions in the jaw, such as radicular cyst and osteomyelitis, have been reported by many authors, there are few reports have previously described Actinomyces-associated calcification in the jaw. We report here a rare case of Actinomyces-associated calcifications around an impacted third molar of the mandible. A 76-year-old man with left mandibular pericoronitis was referred to our department. A panoramic radiograph showed alveolar bone resorption caused by severe periodontitis of the left mandibular second molar and multiple small radiopaque spots around the crown of left mandibular third molar in a radiolucent lesion. Computed tomography revealed that the lesion of the left mandibular retromolar lesion was low density, with multiple high density spots surrounding the third molar crown surface. Removal of the lesion and the left mandibular second and third molars were performed and multiple small black pieces of hard tissue were present on the crown surface of the third molar. Histopathological examination of soft tissue specimen around the third molar revealed that collagenous fibroconnective tissue infiltrated by inflammatory cells with squamous epithelium on its surface. Black hard tissue consisted of calcification and conglomerations of Actinomyces which were densely stained by hematoxylin-eosin stain were observed at the margin of the hard tissue surrounding tiny filamentous structures. The postoperative course was uneventful without need for additional antibiotics and there has been no recurrence 22 months after surgery.

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  • Computational fluid dynamics study of intra-arterial chemotherapy for oral cancer Reviewed

    Kitajima H, Oshima M, Iwai T, Ohhara Y, Yajima Y, Mitsudo K, Tohnai I

    Biomed Eng Online   16 ( 1 )   57   2017.5

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    Background: Intra-arterial chemotherapy (IAC) for oral cancer can deliver a higher concentration of anticancer agent into a tumor-feeding artery than intravenous systemic chemotherapy. However, distribution of anticancer agent into several branches of the external carotid artery (ECA) in IAC has not demonstrated sufficient treatment efficacy. To improve the effectiveness of IAC, the flow distribution of anticancer agent into the branches of the ECA in several IAC methods was investigated using computational fluid dynamics (CFD).
    Methods: Patient-specific three-dimensional vessel models were created from CT images of 2 patients with tongue cancer. Catheter models were combined with the vessel models. Thirty-two models were generated with varying vertical and horizontal positions of the catheter tip. With the use of a zero-dimensional resistance model of the peripheral vessel network, conventional IAC and superselective IAC were simulated in 30 and 2 models, respectively. The flow distribution of anticancer agent into the branches of the ECA was investigated in 32 models. Additionally, the blood streamline was traced from the inlet of the common carotid artery toward each outlet to examine the flow of anticancer agent in all models, and the wall shear stress of the vessel was calculated for some models.
    Results: The CFD simulations could be conducted within a reasonable computational time. In several models, the anticancer agent flowed into the target artery only when the catheter tip was located below the bifurcation of the ECA and each target artery. Furthermore, the anticancer agent tended to flow into the target artery when the catheter tip was shifted toward the target artery. In all ECA branches that had flow of anticancer agent, the blood streamlines to the target arteries contacted the catheter tip. Anticancer agent flowed into only the target artery in patients' models for superselective IAC. However, high wall shear stress was observed at the target artery in one patient's model.
    Conclusions: This CFD study showed that location of the catheter tip was important in controlling the anticancer agent in conventional IAC. The distribution rate of anticancer agent into the tumor-feeding artery tended to increase when the catheter tip was placed below and toward the target artery. Although superselective IAC can reliably supply anticancer agent to the target artery, high wall shear stress at the target artery can occur, depending on vessel geometry of the patient, which may cause serious complications during the treatment.

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  • Application of 4-meta adhesive resin to the occlusal surface during surgery facilitates postoperative occlusal management Reviewed

    Aoki N, Baba J, Iwai T, Tohnai I

    J Maxillofac Oral Surg   16 ( 1 )   131 - 132   2017.3

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  • Maxillary tuberosity fracture and ophthalmologic complications following removal of maxillary third molar Reviewed

    Baba J, Iwai T, Endo H, Aoki N, Tohnai I

    Oral Surg   10 ( 1 )   43 - 47   2017.2

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    Third molar removal is one of the most common procedures performed by dentists and oral surgeons. Removal of maxillary third molar is associated with a lower rate of complication compared to the mandible, and maxillary tuberosity fracture or ophthalmologic complications after removal of maxillary third molar are very rare. We report maxillary tuberosity fracture and ophthalmologic complications following removal of maxillary third molar. A 35-year-old female underwent removal of left maxillary third molar at private dental clinic. Following the complete extraction, excessive haemorrhage occurred and maxillary tuberosity fracture was seen and the patient was brought by ambulance to our hospital. The bleeding was controlled by vacuum-formed splint and nasal packing. Computed tomography revealed that lateral maxillary tuberosity and posterior wall of the maxillary sinus was defect and there was a slight intraorbital haematoma via the inferior orbital fissure as well as with extension in the maxillary sinus and adjacent spaces such as buccal, masticator, pterygomaxillary and infratemporal spaces. Because an ophthalmologist noted only slight diplopia in lateral gaze without abnormal signs in other examinations and nasal and oral bleeding were controlled, the surgical treatment was not required. The patient was immediately hospitalised for close observation. Intravenous antibiotics and steroids were administered. Because swelling of the cheek and buccal mucosa was gradually decreasing without further haemorrhage, the patient was discharged 4 days after the extraction. The diplopia was recovered completely 11 days after the extraction.

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  • Intraoral ultrasonography with wrapped acoustic coupling medium Reviewed

    Sugiura K, Iwai T, Oguri S, Tohnai I

    Br J Oral Maxillofac Surg   55 ( 2 )   202 - 204   2017.2

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  • Use of eXtensible Virtual Word Description Language (XVL) file to embed simply and user-friendly three-dimensional medical data for PowerPoint presentation Reviewed

    Itamiya T, Iwai T, Yajima Y, Kaneko T

    J Craniofac Surg   28 ( 1 )   298 - 299   2017.1

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  • An accurate bimaxillary repositioning technique using straight locking miniplates for the mandible-first approach in bimaxillary orthognathic surgery Reviewed

    Iwai T, Omura S, Honda K, Yamashita Y, Shibutani N, Fujita K, Takasu H, Murata S, Tohnai I

    Odontology   105 ( 1 )   122 - 126   2017.1

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    Bimaxillary orthognathic surgery has been widely performed to achieve optimal functional and esthetic outcomes in patients with dentofacial deformity. Although Le Fort I osteotomy is generally performed before bilateral sagittal split osteotomy (BSSO) in the surgery, in several situations BSSO should be performed first. However, it is very difficult during bimaxillary orthognathic surgery to maintain an accurate centric relation of the condyle and decide the ideal vertical dimension from the skull base to the mandible. We have previously applied a straight locking miniplate (SLM) technique that permits accurate superior maxillary repositioning without the need for intraoperative measurements in bimaxillary orthognathic surgery. Here we describe the application of this technique for accurate bimaxillary repositioning in a mandible-first approach where the SLMs also serve as a condylar positioning device in bimaxillary orthognathic surgery.

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  • Squamous cell carcinoma of the tongue dorsum: incidence and treatment considerations Reviewed

    Okubo M, Iwai T, Nakashima H, Koizumi T, Oguri S, Hirota M, Mitsudo K, Tohnai I

    Indian J Otolaryngol Head Neck Surg   69 ( 1 )   1 - 5   2017.1

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    DOI: 10.1007/s12070-016-0979-z

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  • Computational fluid dynamic study of nasal respiratory function before and after bimaxillary orthognathic surgery with bone trimming at the inferior edge of the pyriform aperture Reviewed International journal

    Kita S, Oshima M, Shimazaki K, Iwai T, Omura S, Ono T

    J Oral Maxillofac Surg   74 ( 11 )   2241 - 2251   2016.11

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    PURPOSE: This study aimed to evaluate the influence of maxillary impaction orthognathic surgery on nasal respiratory function and the efficacy of bone trimming at the inferior edge of the pyriform aperture. MATERIALS AND METHODS: The participants were 10 patients (3 male and 7 female patients) with mandibular prognathism who underwent bimaxillary orthognathic surgery with maxillary impaction. The surgical procedures performed were Le Fort I osteotomy with bone trimming at the inferior edge of the pyriform aperture and bilateral sagittal split osteotomy. Three-dimensional models of the nasal cavity were reconstructed from preoperative and postoperative computed tomography images. Furthermore, we remodeled the nasal valve region based on the postoperative models by adding a 1-mm and 2-mm stenosis to investigate the effects of bone trimming at the inferior edge of the pyriform aperture on the pressure effort. The 3-dimensional models were simulated with computational fluid dynamics, and the results of the pressure effort and the cross-sectional area (CSA) were compared for the anterior, middle, and posterior parts of the nasal cavity. The Wilcoxon signed rank test and Spearman rank correlation coefficients were used for statistical comparisons (P < .05). RESULTS: In the preoperative and postoperative models, there were considerable correlations between the CSA and the pressure effort in each part of the nasal cavity. The postoperative pressure effort showed a tendency to decrease and the CSA showed a tendency to increase in each part of the nasal cavity. In four 2-mm stenosis models, the pressure effort in the anterior nasal cavity was larger than the preoperative pressure effort and the CSA of the anterior nasal cavity was smaller than the preoperative CSA. CONCLUSIONS: Bone trimming at the inferior edge of the pyriform aperture appears to be useful for avoiding nasal respiratory complications with maxillary impaction.

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  • Development of a virtual reality training system for endoscope-assisted submandibular gland removal Reviewed

    Miki T, Iwai T, Kotani K, Dang J, Sawada H, Miyake H

    J Craniomaxillofac Surg   44 ( 11 )   1800 - 1805   2016.11

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    Purpose: Endoscope-assisted surgery has widely been adopted as a basic surgical procedure, with various training systems using virtual reality developed for this procedure. In the present study, a basic training system comprising virtual reality for the removal of submandibular glands under endoscope assistance was developed. The efficacy of the training system was verified in novice oral surgeons.
    Material and methods: A virtual reality training system was developed using existing haptic devices. Virtual reality models were constructed from computed tomography data to ensure anatomical accuracy. Novice oral surgeons were trained using the developed virtual reality training system.
    Results: The developed virtual reality training system included models of the submandibular gland and surrounding connective tissues and blood vessels entering the submandibular gland. Cutting or abrasion of the connective tissue and manipulations, such as elevation of blood vessels, were reproduced by the virtual reality system. A training program using the developed system was devised. Novice oral surgeons were trained in accordance with the devised training program.
    Conclusions: Our virtual reality training system for endoscope-assisted removal of the submandibular gland is effective in the training of novice oral surgeons in endoscope-assisted surgery. (C) 2016 The Author(s). Published by Elsevier Ltd on behalf of European Association for Cranio-Maxillo-Facial Surgery.

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  • Use of Occlusal Splint for Noninvasive Fixation of a Reference Frame in Orbital Navigation Surgery. Reviewed

    Iwai T, Mikami T, Yasumura K, Tohnai I, Maegawa J

    15 ( 3 )   410 - 412   2016.9

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  • Implant stability development of photofunctionalized implants placed in regular and complex cases: A case-control study Reviewed

    Hirota M, Ozawa T, Iwai T, Ogawa T, Tohnai I

    Int J Oral Maxillofac Implants   31 ( 3 )   676 - 686   2016.5

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    Purpose: The objective of this study was to compare the rate of implant stability development of as-received and photofunctionalized dental implants in regular and complex cases. Materials and Methods: Forty-nine implants (24 as-received and 25 photofunctionalized) placed in regular or complex cases (simultaneous guided bone regeneration, sinus elevation, or fresh extraction sockets) were studied. Photofunctionalization was performed by ultraviolet (UV) treatment of implants for 15 minutes using a photo device immediately prior to placement, and the generation of superhydrophilicity was conirmed. Implant stability was evaluated by measuring the implant stability quotient (ISQ) at placement (ISQ1) and at stage-two surgery (ISQ2). The rate of implant stability development was evaluated by calculating the osseointegration speed index (OSI), deined as the ISQ increase per month ([ISQ2-ISQ1]/healing time in months). The percentage of innate bone support at placement was evaluated clinically and radiographically. Results: The average OSI was considerably greater for photofunctionalized implants (3.7 +/- 2.9) than for as-received implants (0.0 +/- 1.0). The OSI in complex cases was 4.2 +/- 3.2 for photofunctionalized implants and 0.2 +/- 0.9 for as-received implants. The OSI in cases with simultaneous sinus elevation was 5.5 +/- 3.5 for photofunctionalized implants and 0.2 +/- 1.1 for as-received implants. Photofunctionalized implants showed signiicantly higher ISQ2 values than as-received implants. Photofunctionalized implant ISQ2 values were greater than 60, regardless of primary stability and innate bone support at placement. In multivariate analysis including the effects of photofunctionalization, age and sex of patients, and diameter and length of implants, photofunctionalization showed the strongest inluence on the OSI for both regular and complex cases, while other factors inluenced the OSI only in certain conditions. Conclusion: Photofunctionalization accelerated the rate and enhanced the final level of implant stability development compared with as-received implants, particularly for implants placed into poor-quality bone and other complex cases. Photofunctionalization was a stronger determinant of implant stability than all the other tested implant-and host-related factors.

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  • Reduction surgery using a combination of a stereolithographic model and navigation system for ossifying fibroma with secondary central giant cell granuloma. Reviewed International journal

    Arai Y, Chiba Y, Umeda S, Ohara Y, Iwai T, Komatsu M, Yabuki K, Sano D, Oridate N

    Auris Nasus Larynx   43 ( 2 )   207 - 211   2016.4

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    Both central giant cell granuloma (CGCG) and ossifying fibroma (OF) are relatively common diseases. The synchronous presentation of CGCG and OF is, however, an extremely rare occurrence. We present an unusual case with the synchronous presentation of these two diseases in the maxilla and introduce a surgical strategy based on a combination of the stereolithographic model and navigation system for the treatment of gigantic OF with secondary CGCG.

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  • Prognostic value of 2-[(18) F]fluoro-2-deoxy-D-glucose positron emission tomography for patients with oral squamous cell carcinoma treated with retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy Reviewed

    Shimizu M, Mitsudo K, Koike I, Taguri M, Iwai T, Koizumi T, Oguri S, Kioi M, Hirota M, Inoue T, Tohnai I

    Oral Surg Oral Med Oral Pathol Oral Radiol   121 ( 3 )   239 - 247   2016.3

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    Objective. To investigate whether 2-[(18) F] fluoro-2-deoxy-D-glucose (FDG) uptake of primary tumor in oral squamous cell carcinoma (OSCC) could predict prognosis.
    Study Design. Sixty-nine patients with OSCC who underwent retrograde superselective intra-arterial chemoradiotherapy were recruited and underwent dual-time-point FDG positron emission tomography twice, before treatment and 4 weeks after treatment. FDG uptake was defined as the standardized uptake value (SUVmax). The retention index (RI) and the percent change in SUV (% change SUV), derived from the dual-time-point scan, were calculated.
    Results. On univariate analysis, patients with high pre-SUV, RI, and percent change SUV values had significantly worse overall survival and disease-free survival compared with patients with low values. On multivariate analysis, high pre-RI (&gt;= 20.6%) and high percent change SUV (&gt;= 60.0%) (delayed-image) were associated with significantly worse overall survival. High pre-SUV (&gt;= 9.6) (delayed-image) and high pre-RI (&gt;= 20.6%) were associated with significantly shorter disease-free survival.
    Conclusions. Dual-time-point FDG positron emission tomography in OSCC provided prognostic information and predicted patient outcome.

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  • Investigation of blood flow in the external carotid artery and its branches with a new 0D peripheral model Reviewed

    Ohhara Y, Oshima M, Iwai T, Kitajima H, Yajima Y, Mitsudo K, Krdy A, Tohnai I

    Biomed Eng Online   15 ( 1 )   16   2016.2

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    Background: Patient-specific modelling in clinical studies requires a realistic simulation to be performed within a reasonable computational time. The aim of this study was to develop simple but realistic outflow boundary conditions for patient-specific blood flow simulation which can be used to clarify the distribution of the anticancer agent in intra-arterial chemotherapy for oral cancer.
    Methods: In this study, the boundary conditions are expressed as a zero dimension (0D) resistance model of the peripheral vessel network based on the fractal characteristics of branching arteries combined with knowledge of the circulatory system and the energy minimization principle. This resistance model was applied to four patient-specific blood flow simulations at the region where the common carotid artery bifurcates into the internal and external carotid arteries.
    Results: Results of these simulations with the proposed boundary conditions were compared with the results of ultrasound measurements for the same patients. The pressure was found to be within the physiological range. The difference in velocity in the superficial temporal artery results in an error of 5.21 +/- 0.78 % between the numerical results and the measurement data.
    Conclusions: The proposed outflow boundary conditions, therefore, constitute a simple resistance-based model and can be used for performing accurate simulations with commercial fluid dynamics software.

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  • Development of a biointegrated mandibular reconstruction device consisting of bone compatible titanium fiber mesh scaffold Reviewed

    Hirota M, Shima T, Sato I, Ozawa T, Iwai T, Ametani A, Sato M, Noishiki Y, Ogawa T, Hayakawa T, Tohnai I

    Biometerials   75   223 - 236   2016.1

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    Coating biomaterials with a thin hydroxyapatite (HA) was proven effective in enhancing bone compatibility. Segmental bone defects are considered as the most difficult defect to repair in bone regeneration therapy. We developed submicron-thin HA-coated titanium fiber mesh scaffolds to reconstruct immediately loaded segmental mandibular defects and evaluated their bone compatibility in vitro and in vivo. Human osteoblasts attachment, proliferation, and osteocalcin expression in non- and HA-coated scaffolds were evaluated. A 10-mm long segmental bone defect in a rabbit mandibular bone was reconstructed with non- or HA-coated scaffolds, which were removed at 9 and 21 weeks, to evaluate the mechanical strength of the bone-scaffold connection and the bone formation around the scaffold. Expression of osteocalcin was greater in HA-coated scaffolds. In vivo bone formation in HA-coated scaffolds was greater than that in non-coated scaffolds at 21 weeks. Newly formed bone in HA-coated scaffolds mostly restored bone continuity. Scanning electron microscopy identified strong integration of the bone and HA-coated scaffolds. The mechanical strength of the bone-scaffold connection was 3-fold greater in HA-coated scaffolds than that in non-coated scaffolds. These results suggest that a thin HA-coated titanium fiber mesh scaffold is a bone-compatible mandibular reconstruction device in immediately loaded segmental defects. (C) 2015 Elsevier Ltd. All rights reserved.

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  • Removal of migrated dental implants from maxillary sinus 4 years 10 months after implant placement. Reviewed International journal

    19 ( 3 )   315 - 319   2015.9

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    INTRODUCTION: Dental implant treatment has been applied widely in recent years. However, several complications sometimes have been reported. Although displacement of dental implants into the maxillary sinus commonly occurs during surgery, the migration of dental implants after a period of function, especially several years after dental implant placement, is very rare. CASE REPORT: We report here removal of migrated dental implants from the maxillary sinus 4 years and 10 months after dental implant placement.

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  • Subspinal osteotomy for simple extraction of deeply impacted supernumerary tooth in the anterior maxilla Reviewed

    Aoki N, Iwai T, ENdo I, Baba J, Tohnai I

    J Oral Maxillofac Surg Med Pathol   27 ( 5 )   670 - 672   2015.9

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  • U-shaped osteotomy around the descending palatine artery to prevent posterior osseous interference for superior/posterior repositioning of the maxilla in Le Fort I osteotomy Reviewed

    Omura S, Iwai T, Honda K, Shibutani N, Fujita K, Yamashita Y, Takasu H, Murata S, Tohnai I

    J Craniofac Surg   26 ( 5 )   1613 - 1615   2015.7

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    In maxillary orthognathic surgery, superior repositioning of the maxilla is sometimes difficult, and removal of bony interference, especially around the descending palatine artery ( DPA), is very time-consuming in cases of severe maxillary impaction. Posterior repositioning of the maxilla for removal of bony interference between the posterior maxilla and the pterygoid process is also technically difficult. Because the most common site of hemorrhage in Le Fort I osteotomy is the posterior maxilla, this bone removal is a source of frustration for surgeons in DPA injury. When the DPA is injured during bone removal and ligation is performed, aseptic necrosis of the maxilla may occur. Therefore, a simple and safe method for maxillary superior/posterior repositioning is required to remove osseous interference around the DPA. The authors describe here U-shaped osteotomy around the DPA to prevent posterior osseous interference for superior/posterior repositioning of the maxilla in Le Fort I osteotomy.

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  • Communication between the transverse cervical nerve and the marginal mandibular branch of the facial nerve: A rare anatomical variant Reviewed

    Iwai T, Shibasaki M, Nakashima H, Oguri S, Hirota M, Mitsudo K, Tohnai I

    1 ( 1 )   9 - 10   2015.6

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  • Use of self-tapping metal screws for temporary fixation of a resorbable plate system in maxillofacial surgery Reviewed

    Iwai T, Omura S, Aoki N, Tohnai I

    J Craniofac Surg   26 ( 3 )   891 - 892   2015.5

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    Resorbable plate systems have been used in maxillofacial surgery to obviate the need for plate removal. However, resorbable plates and screws are very costly, and refixation with additional screws may be necessary when reduction or repositioning of the bone segment is inaccurate. Here we report the use of self-tapping metal screws for temporary fixation of a resorbable plating system in maxillofacial surgery to avoid the use of additional screws following inaccurate fixation or the reuse of resorbable screws, which may result in loosening.

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    DOI: 10.1097/SCS.0000000000001415

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  • Vital staining of palatal soft tissue in horseshoe Le Fort I osteotomy for superior repositioning of the maxilla. Reviewed International journal

    Omura S, Iwai T, Honda K, Shibutani N, Fujita K, Yamashita Y, Takasu H, Murata S, Tohnai I

    J Craniofac Surg   26 ( 3 )   911 - 913   2015.5

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    In maxillary orthognathic surgery, superior repositioning of the maxilla is sometimes difficult, and removal of the bony interference, especially around the descending palatine artery, is very time-consuming in cases of severe maxillary impaction. A useful method introduced for superior repositioning of the maxilla is horseshoe-shaped osteotomy combined with Le Fort I osteotomy (horseshoe Le Fort I osteotomy). However, injury to the palatal soft tissue during horseshoe-shaped osteotomy may cause aseptic complications of the maxilla. Therefore, a safe method is required to prevent such injury to reduce the risk for aseptic necrosis. We describe here vital staining of palatal soft tissue in horseshoe Le Fort I osteotomy for safer superior repositioning of the maxilla.

    File: Vital staining.pdf

    DOI: 10.1097/SCS.0000000000001420

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  • Effect of ultraviolet-mediated photofunctionalization for bone formation around medical titanium mesh Reviewed

    Hirota M, Ikeda T, Tabuchi M, Iwai T, Tohnai I, Ogawa T

    J Oral Maxillofac Surg   72 ( 9 )   1691 - 1702   2014.9

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    Purpose: The new technology of photofunctionalization with ultraviolet (UV) light for titanium implants has earned considerable attention. We hypothesized that UV light treatment would enhance bone formation on titanium mesh.
    Materials and Methods: We implemented in vitro and in vivo experiments to examine the effectiveness of UV treatment for bone formation on titanium mesh surfaces. Titanium mesh for medical use was prepared as samples, which were autoclaved and stored under dark ambient conditions for 4 weeks. UV treatment was performed for 12 minutes. Carbon contamination, hydrophilicity, and protein adhesion of the titanium mesh surface were examined in an in vitro model. Bone tissue formation around the titanium mesh was observed in a rat femur bone model. The Mann-Whitney U test was used to examine differences between the untreated and UV-treated groups. P values of &lt; .05 were considered significant.
    Results: UV-mediated photofunctionalization reduced carbon contamination rates on the untreated titanium mesh surfaces. The hydrophobic surface of the untreated titanium mesh became superhydrophilic after UV-mediated photofunctionalization (P &lt; .01). The amount of protein adsorbed onto the titanium was 1.5 to 3 times greater on the photofunctionalized titanium mesh surfaces than on the untreated titanium mesh surfaces (P &lt; .01). In the animal experiment, the newly formed bone on the UV-treated titanium mesh was approximately 2.5 times greater than that on the untreated mesh (P &lt; .05).
    Conclusions: UV-mediated photofunctionalization is effective, as demonstrated by the enhanced bone tissue formation on the titanium mesh. Future studies will focus on bone augmentation using an UV-mediated photofunctionalized titanium implant and mesh. (C) 2014 American Association of Oral and Maxillofacial Surgeons

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  • Secure surgical method for catheter placement via the occipital artery to achieve retrograde superselective intra-arterial chemotherapy for advanced oral cancer: Alternative to approach via the superficial temporal artery Reviewed International journal

    Iwai T, Fuwa N, Hirota M, Mitsudo K, Tohnai I

    Indian J Otolaryngol Head Neck Surg   66 ( 2 )   205 - 207   2014.6

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    We describe secure surgical method for catheter placement using ultrasonic scalpel via the occipital artery to achieve retrograde superselective intra-arterial chemotherapy for advanced oral cancer, as alternative to approach via the superficial temporal artery.

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    DOI: 10.1007/s12070-012-0501-1

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  • Hyperthermia generated with ferucarbotran (Resovist(A (R))) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells Reviewed

    JOURNAL OF PHYSIOLOGICAL SCIENCES   64 ( 3 )   177 - 183   2014.5

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    Hyperthermia is a promising anti-cancer treatment in which the tissue temperature is increased to 42-45 A degrees C, and which is often used in combination with chemotherapy or radiation therapy. Our aim in the present work was to examine the feasibility of combination therapy for oral cancer with cisplatin and hyperthermia generated with ferucarbotran (Resovist(A (R)); superparamagnetic iron oxide) in an alternating magnetic field (AMF). First, we established that administration of ferucarbotran at the approved dosage for magnetic resonance imaging provides an iron concentration sufficient to increase the temperature to 42.5 A degrees C upon exposure to AMF. Then, we examined the effect of cisplatin combined with ferucarbotran/AMF-induced hyperthermia on cultured human oral cancer cells (HSC-3 and OSC-19). Cisplatin alone induced apoptosis of cancer cells in a dose-dependent manner, as is well known. However, the combination of cisplatin with ferucarbotran/AMF was significantly more effective than cisplatin alone. This result suggests that it might be possible to reduce the clinically effective dosage of cisplatin by administering it in combination with ferucarbotran/AMF-induced hyperthermia, thereby potentially reducing the incidence of serious cisplatin-related side effects. Further work seems justified to evaluate simultaneous thermo-chemotherapy as a new approach to anticancer therapy.

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    DOI: 10.1007/s12576-014-0309-8

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  • Malignant melanoma of the lacrymal sac: a case report Reviewed

    Maegawa J, Yasumura K, Iwai T, Hata M, Inayama Y, Kobayashi S

    Int J Dermatol   53 ( 2 )   243 - 245   2014.2

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  • Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer: Analysis of therapeutic results in 112 cases Reviewed

    Mitsudo K, Koizumi T, Iida M, Iwai T, Nakashima H, Oguri S, Kioi M, Hirota M, Koike I, Hata M, Tohnai I

    Radiother Oncol   111 ( 2 )   306 - 310   2014.2

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  • Variable oral device for measuring oral lesions. Reviewed

    Iwai T, Maegawa J, Matsui Y, Mitsudo K, Tohnai I

    66 ( Suppl 1 )   314 - 315   2014.1

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  • Cervicofacial subcutaneous emphysema associated with dental laser treatment. Reviewed International journal

    Mitsunaga S, Iwai T, Kitajima H, Yajima Y, Ohya T, Hirota M, Mitsudo K, Aoki N, Yamashita Y, Omura S, Tohnai I

    Aust Dent J   58 ( 4 )   424 - 427   2013.12

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    Cervicofacial subcutaneous emphysema is a rare complication of dental procedures. Although most cases of emphysema occur incidentally with the use of a high-speed air turbine handpiece, there have been some reports over the past decade of cases caused by dental laser treatment. Emphysema as a complication caused by the air cooling spray of a dental laser is not well known, even though dental lasers utilize compressed air just as air turbines and syringes do. In this study, we comprehensively reviewed cases of emphysema attributed to dental laser treatment that appeared in the literature between January 2001 and September 2012, and we included three such cases referred to us. Among 13 cases identified in total, nine had cervicofacial subcutaneous and mediastinal emphysema. Compared with past reviews, the incidence of mediastinal emphysema caused by dental laser treatment was higher than emphysema caused by dental procedure without dental laser use. Eight patients underwent CO2 laser treatment and two underwent Er:YAG laser treatment. Nine patients had emphysema following laser irradiation for soft tissue incision. Dentists and oral surgeons should be cognizant of the potential risk for iatrogenic emphysema caused by the air cooling spray during dental laser treatment and ensure proper usage of lasers.

    File: Australian Dental Journal - 2013 - Mitsunaga - Cervicofacial subcutaneous emphysema associated with dental laser treatment.pdf

    DOI: 10.1111/adj.12119

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  • Intraoperative lacrimal intubation to prevent epiphora as a result of injury to the nasolacrimal system after fracture of the naso-orbitoethmoid complex Reviewed

    Iwai T, Yasumura K, Yabuki Y, Omura S, Matsui Y, Kobayashi S, Fujimaki R, Okubo M, Tohnai I, Maegawa J

    Br J Oral Maxillofac Surg   51 ( 7 )   E165 - E168   2013.10

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    Treatment of fracture of the naso-orbitoethmoid (NOE) complex is difficult. There are not only aesthetic issues but also functional consequences related to the lacrimal system. Because prophylactic lacrimal intubation for such fractures remains controversial, we have assessed the effectiveness of intraoperative lacrimal intubation to prevent epiphora as a result of such injuries. Thirteen patients diagnosed with craniomaxillofacial fractures including fractures of the NOE complex were included in the study; 10 had unilateral fractures and 3 bilateral. Computed tomography (CT) showed all patients had displaced fragments that had the potential to damage the lacrimal duct. In 7 patients the fractures included the canthal region and in 6 they did not. All patients were treated by open reduction and internal fixation under general anaesthesia, followed by intraoperative lacrimal intubation unilaterally or bilaterally as required. Lacrimal intubation with a silicone tube was successful in all 13 patients (16 sides). The tube was removed 2-9 months (mean 3.8) postoperatively and no subsequent epiphora were seen during follow-up (mean (3-29 months) 11.3 months). Lacrimal intubation for at least 2 months may prevent epiphora caused by injury to the nasolacrimal system after fractures of the NOE complex. (C) 2012 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

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    DOI: 10.1016/j.bjoms.2012.07.005

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  • Bisphosphonate-related enamel hypoplasia in a child with idiopathic arterial calcification of infancy Reviewed

    Iwai T, Isomatsu Y, Iwamoto M, Tohnai I

    Br J Oral Maxillofac Surg   51 ( 7 )   e186 - e187   2013.10

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    We report bisphosphonate-related enamel hypoplasia as a rare side effect in a child with idiopathic arterial calcification of infancy. © 2012 The British Association of Oral and Maxillofacial Surgeons.

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    DOI: 10.1016/j.bjoms.2012.05.008

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  • Ultrasonic vertical osteotomy of the distal segment for safe elimination of interference between the proximal and distal segments in bilateral sagittal split osteotomy for mandibular asymmetry Reviewed

    Iwai T, Maegawa J, Aoki S, Tohnai I

    Br J Oral Maxillofac Surg   51 ( 7 )   E192 - E194   2013.10

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    File: ultrasonic osteotomy.pdf

    DOI: 10.1016/j.bjoms.2012.05.012

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  • Safe method of extraction to prevent a deeply-impacted maxillary third molar being displaced into the maxillary sinus Reviewed

    Iwai T, Chikumaru H, Shibasaki M, Tohnai I

    Br J Oral Maxillofac Surg   51 ( 5 )   E75 - E76   2013.7

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    DOI: 10.1016/j.bjoms.2012.04.076

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  • Mandibular Ewing sarcoma With chromosomal translocation t(21;22)(q22;q12) Reviewed

    Shibasaki M, Iwai T, Maegawa J, Inayama Y, Yokosuka T, Yokota S, Ohta S, Matsui Y, Mitsudo K, Tohnai I

    J Craniofac Surg   24 ( 4 )   1469 - 1472   2013.7

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    Ewing sarcoma (ES) is a primary bone malignant neoplasm and is the second most common primary malignancy of the bone found in childhood and adolescence after osteosarcoma. ES has an annual frequency in the population younger than 20 years of approximately 2.9 per million. ES occurs most frequently in the long bones of the extremities and pelvis and very rarely in the jaw. Recently, it was revealed that chromosomal translocation t(11;22)(q24;q12), which fuses the EWS gene on chromosome 22 and the FLI-1 gene on chromosome 11, occurs inmost cases of ES. We report here a rare case of mandibular ES in a 10-year-old child with chromosomal translocation t(21;22)(q22;q12) in which the EWS gene is fused with the ERG gene on chromosome 21.

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  • Cervicofacial subcutaneous and mediastinal emphysema caused by air cooling spray of dental laser Reviewed

    Mitsunaga S, Iwai T, Aoki N, Yamashita Y, Omura S, Matsui Y, Maegawa J, Hirota M, Mitsudo K, Tohnai I

    Oral Surg Oral Med Oral Pathol Oral Radiol   115 ( 6 )   E13 - E16   2013.6

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    Cervicofacial subcutaneous emphysema is a rare complication of dental procedures with an air turbine or syringe, and dentists and oral surgeons sometimes encounter mediastinal emphysema following the presentation of extensive subcutaneous emphysema. Most emphysema occurs incidentally during tooth extraction, restorative treatment, or endodontic treatment, with only a few cases reported of cervicofacial subcutaneous emphysema associated with dental laser treatment. We report a case of cervicofacial subcutaneous and mediastinal emphysema caused by the air cooling spray of dental laser during dental treatment in a 76-year-old woman. After she underwent dental laser treatment, cervicofacial swelling was noted and she was referred to our department. Computed tomography showed both cervicofacial subcutaneous emphysema and mediastinal emphysema. Antibiotics were administered prophylactically and the emphysema disappeared 5 days after the dental laser treatment, without any complications.

    File: Laser emphysema.pdf

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  • Peripheral Osteoma of the Mandibular Notch: Report of a Case Reviewed

    Iwai T, Izumi T, Baba J, Maegawa J, Mitsudo K, Tohnai I

    Iran J Radiol   10 ( 2 )   74 - 76   2013.6

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    Osteoma is a benign, slow-growing osteogenic tumor that sometimes arises from the craniomaxillofacial region, such as the sinus, temporal or jaw bones. Osteoma consists of compact or cancellous bone that may be peripheral, central or extraskeletal type. Peripheral osteoma arises from the periosteum and is commonly a unilateral, pedunculated mushroom-like mass. Peripheral osteoma of the mandible is relatively uncommon, and peripheral osteoma of the mandibular notch is extremely rare, although many cases arise from the mandibular body, angle, condyle, or coronoid process. We report here an unusual peripheral osteoma of the mandibular notch in a 78-year-old nonsyndromic female.

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    DOI: 10.5812/iranjradiol.3734

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  • Use of a dial tension gauge to assess quantitatively intraoperative improvement of ocular movement after endoscopic transantral repair of fracture of the orbital floor Reviewed

    Iwai T, Yasumura K, Mikami T, Maegawa J

    Br J Oral Maxillofac Surg   51 ( 6 )   e135 - e136   2013.6

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  • Use of a simple handmade retractor to protect the descending palatine artery during removal of posterior osseous interferences for maxillary impaction in Le Fort I osteotomy Reviewed

    Omura S, Iwai T, Murata S, Tohnai I

    J Craniofac Surg   24 ( 3 )   978 - 979   2013.5

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    For accurate superior or posterior repositioning of the maxilla in Le Fort I osteotomy, bone removal around the descending palatine artery (DPA) and maxillary tuberosity is required. Because the most common site of hemorrhage in the Le Fort I osteotomy is the posterior maxilla, this bone removal provides surgeons to surgical frustration of DPA injury. When the DPA is injured during the bone removal and the ligation is performed, aseptic necrosis of the maxilla may occur. Therefore, we report the use of a simple handmade retractor to protect the DPA in Le Fort I osteotomy.

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    DOI: 10.1097/SCS.0b013e318285d491

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  • Actinomyces-associated calcifications in a dentigerous cyst of the mandible Reviewed

    Shibasaki M, Iwai T, Chikumaru H, Mitsudo K, Inayama Y, Tohnai I

    J Craniofac Surg   24 ( 3 )   E311 - E314   2013.5

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    Actinomyces-associated lesions in the jaw, such as radicular cyst and osteomyelitis, have been reported by many authors. The lesions are caused by infection from peripheral sites and can be seen to contain Actinomyces druses on pathologic examination. To our knowledge, no previous reports have described Actinomyces-associated calcification in the jaw, although the lesions in the jaw often include druses. We report here a rare case of Actinomyces-associated calcifications in a dentigerous cyst of the mandible.

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    DOI: 10.1097/SCS.0b013e31828f2e72

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  • High-dose zoledronic acid narrows the periodontal space in rats Reviewed

    Okamoto Y, Hirota M, Monden Y, Murata S, Koyama C, Mitsudo K, Iwai T, Ishikawa Y, Tohnai I

    Int J Oral Maxillofac Surg   42 ( 5 )   627 - 631   2013.5

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    The aim of this experiment was to evaluate the histological effects of zoledronic acid on the periodontal space in rats. 40 male Wistar rats were divided into three zoledronic acid groups and a control group. Zoledronic acid was injected subcutaneously at doses of 10, 50, or 500 μg/kg once a week for 3 weeks. The rats were killed 1 or 9 weeks after the last injection. Histological examination of the periodontal space around the incisor tooth revealed that zoledronic acid did not inhibit tooth development. In the rats killed 1 week after treatment discontinuation, the periodontal space gradually narrowed in response to increasing zoledronic acid doses, and the changes were statistically significant according to ANOVA but not according to ANOVA with post hoc tests. The changes persisted in the high-dose zoledronic acid group despite zoledronic acid discontinuation, with significant differences identified by ANOVA and ANOVA with post hoc tests. Therefore, although zoledronic acid had an insignificant effect on tooth development, it had a significant effect on the periodontal space when high doses were administered. The results of this experiment may provide useful information for future investigations on the role of zoledronic acid in the osteonecrosis of the jaw. © 2012 International Association of Oral and Maxillofacial Surgeons.

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    DOI: 10.1016/j.ijom.2012.11.011

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  • Osteomyelitis of the jaws associated with osteopetrosis: case report of two sisters Reviewed

    Adachi M, Iwai T, Watanuki K, Masuda G, Tohnai I

    Oral Surg   6 ( 2 )   73 - 76   2013.5

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  • Recurrent endocrine mucin-producing sweat gland carcinoma in the eyelid Reviewed

    Koike T, Mikami T, Maegawa J, Iwai T, Wada H, Yamanaka S

    Australas J Dermatol   54 ( 2 )   e46 - e49   2013.5

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    Endocrine mucin-producing sweat gland carcinoma (EMPSGC) has recently been recognised as a low-grade carcinoma that almost always occurs on the eyelid. This carcinoma is very rare, with only 20 cases (including the present one) having been reported in the literature. EMPSGC is frequently found in association with invasive mucinous carcinoma. While EMPSGC treatments consist of a complete surgical removal, there has been no consensus regarding the surgical margin. Therefore, reports on surgical management of EMPSGC may potentially provide important therapeutic information. Here, we present a case of a 74-year-old man with EMPSGC of the eyelid that repeatedly recurred despite surgical treatments at another institution. After referral to our department, the patient underwent tumour excision. However, the specimen revealed a positive surgical margin and thus, he subsequently underwent a wider excision. There has been no sign of tumour recurrence or metastasis 6 months after his last operation. This article reviews the current literature and discusses the surgical management of EMPSGC. © 2012 The Authors. Australasian Journal of Dermatology © 2012 The Australasian College of Dermatologists.

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  • Sentinel lymph node biopsy using a new indocyanine green fluorescence imaging system with a colour charged couple device camera for oral cancer Reviewed

    Iwai T, Maegawa J, Hirota M, Tohnai I

    Br J Oral Maxillofac Surg   51 ( 2 )   E26 - E28   2013.3

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  • Endoscopic hemostasis with an ultrasonically activated device for hemorrhage from a branch of the maxillary artery during endoscopically assisted reduction of condylar neck fracture Reviewed

    Iwai T, Matsui Y, Omura S, Tohnai I

    J Craniofac Surg   24 ( 2 )   534 - 535   2013.3

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    We describe here a case in which sudden hemorrhage from a branch of the maxillary artery during endoscopically assisted transoral reduction of condylar neck fracture was successfully controlled by endoscopic hemostasis with an ultrasonically activated device.

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  • Hematoma of the tongue Reviewed

    51 ( 2 )   184   2013.3

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  • Cartilaginous choristoma of the lower lip Reviewed

    Shibasaki M, Iwai T, Chikumaru H, Inayama Y, Tohnai I

    J Craniofac Surg   24 ( 2 )   E192 - E194   2013.3

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    Choristoma is a tumor-like mass consisting of normal cells in an abnormal location. Cartilaginous choristoma, which is composed of ectopic cartilaginous tissue, very rarely presents in the oral cavity and most commonly in the tongue. Here we report an extremely rare case of cartilaginous choristoma of the lower lip.

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  • Response to the comments on "An accurate maxillary superior repositioning technique without intraoperative measurement in bimaxillary orthognathic surgery" Reviewed

    Omura S, Iwai T, Kimizuka S, Tohnai I

    Int J Oral Maxillofac Surg   42 ( 3 )   420 - 421   2013.3

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  • Thyrolinguofacial trunk arising from the carotid bifurcation determined by three-dimensional computed tomography angiography Reviewed

    Iwai T, Izumi T, Inoue T, Fuwa N, Shibasaki M, Oguri S, Mitsudo K, Tohnai I

    Surg Radiol Anat   35 ( 1 )   75 - 78   2013.1

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    It is recognized that the branches of the external carotid artery (ECA) can show variation, but the presence of a thyrolinguofacial trunk is extremely rare and always originates from the ECA. We report a case of the thyrolinguofacial trunk arising from the carotid bifurcation (CB) on the left side in a 76-year-old man with advanced tongue cancer, as revealed by three-dimensional computed tomography angiography for vascular mapping of the carotid vessels prior to superselective intra-arterial catheterization. The thyrolinguofacial trunk arose 1.6 mm below the CB from the anterior surface of the left CB. The inner diameter of the thyrolinguofacial trunk at origin was 4.4 mm and the angle between the thyrolinguofacial trunk and CB was 128. After a 1.7-mm course, the trunk divided into the superior thyroid artery and a linguofacial trunk, the inner diameters of which were 1.5 and 3.4 mm, respectively, at origin. The angle between the two arteries was 88. After a 9.8-mm course from the bifurcation, the linguofacial trunk divided into the lingual artery and facial artery, the inner diameters of which were 1.8 and 1.9 mm, respectively, at origin. The angle between the two arteries was 61. It is important to recognize such an anatomic variation of the branches of the ECA prior to superselective intra-arterial catheterization or microsurgical reconstruction for head and neck cancer. © 2012 Springer-Verlag.

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    DOI: 10.1007/s00276-012-1004-1

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  • Computer-assisted preoperative simulation for screw fixation of fractures of the condylar head Reviewed

    Iwai T, Yajima Y, Matsui Y, Tohnai I

    Br J Oral Maxillofac Surg   51 ( 2 )   176 - 177   2013

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    DOI: 10.1016/j.bjoms.2012.03.021

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  • Radiation-induced fibrosarcoma after radiotherapy for osteosarcoma in the mandibular condyle. Reviewed

    Adachi M, Iwai T, Hirota M, Tohnai I

    J Craniodac Surg   23 ( 6 )   E619 - E621   2012.11

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    With recent improvements in survival duration after cancer treatment, it is becoming increasingly important to study treatment-related morbidity and mortality. Radiation-induced sarcomas in the irradiated field are well-known potential late sequelae of radiotherapy. These tumors are biologically aggressive. In the case described here, a radiation-induced fibrosarcoma appeared at 20 years after initial surgery, radiotherapy, and chemotherapy for an osteosarcoma of the mandibular condyle. Radiation-induced fibrosarcoma is relatively rare in the head and neck region. The details of this case are presented, and diagnostic and management considerations are described.

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  • Hydroxyapatite coating for titanium fibre mesh scaffold enhances osteoblast activity and bone tissue formation Reviewed

    Hirota M, Hayakawa T, Yoshinari M, Ametani S, Shima T, Monden Y, Ozawa T, Sato M, Koyama C, Tamai N, Iwai T, Tohnai I

    Int J Oral Maxillofac Surg   41 ( 10 )   1304 - 1309   2012.10

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    This study investigated the bone regeneration properties of titanium fibre mesh as a tissue engineering material. A thin hydroxyapatite (HA) coating on the titanium fibre web was created using the developed molecular precursor method without losing the complex interior structure. HA-coated titanium fibre mesh showed apatite crystal formation in vitro in a human osteoblast culture. Titanium fibre mesh discs with or without a thin HA coating were implanted into rat cranial bone defects, and the animals were killed at 2 and 4 weeks. The in vivo experience revealed that the amount of newly formed bone was significantly higher in the HA-coated titanium fibre mesh than in the non-coated titanium fibre mesh 2 weeks after implantation. These results suggest that thin HA coating enhances osteoblast activity and bone regeneration in the titanium fibre mesh scaffold. Thin HA-coating improved the ability of titanium fibre mesh to act as a bone regeneration scaffold.

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  • 18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. Reviewed International journal

    Iwai T, Baba J, Shibasaki M, Omura S, Hirota M, Mitsudo K, Tohnai I

    J Craniofac Surg   23 ( 5 )   e507-9 - e509   2012.9

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    We report 18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with positron emission tomography/computed tomography.

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  • Warthin tumor arising from the minor salivary gland Reviewed

    Iwai T, Baba J, Murata S, Mitsudo K, Maegawa J, Nagahama K, Tohnai I

    J Craniofac Surg   23 ( 5 )   E374 - E376   2012.9

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    Warthin tumor (WT) accounts for 4% to 13% of all salivary gland tumors. This benign tumor, which commonly arises in the parotid gland, is the second most common tumor of the salivary gland. WT is multicentric in 12% to 20% of patients and is bilateral in 5% to 14%. The mean age at diagnosis is 62 years (range, 12-92 years), and it rarely presents (&lt;6%) before age 40 years. Extraparotid WT, arising from the submandibular gland or cervical lymph node for example, is very infrequent, with corresponding incidences of 0.4% to 6.9% and 8%, respectively. Moreover, WT arising from the minor salivary gland is extremely rare, with a reported incidence of merely 0.1% to 1.2%. We report here WT arising from the minor salivary gland in the buccal mucosa in a 66-year-old woman and review cases of WT of the minor salivary gland reported in the English literature.

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  • Endoscopic removal of throat-packing gauze swallowed during general anesthesia Reviewed

    Iwai T, Goto T, Matsui Y, Tohnai I

    J Craniofac Surg   23 ( 5 )   1547 - 1549   2012.9

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    Throat packing is commonly placed in the pharynx before starting oral and maxillofacial surgery under general anesthesia to protect the airway from aspiration of blood and surgical debris. Complications such as airway obstruction may arise if any of the throat packing is retained after extubation, and less commonly, swallowing of the throat packing has been reported. We report endoscopic removal of throat packing gauze swallowed during general anesthesia.

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  • Analysis of carotid artery deformation in different head and neck positions for maxillofacial catheter navigation in advanced oral cancer treatment Reviewed

    Ohya T, Iwai T, Luan K, Kato T, Liao H, Kobayashi E, Mitsudo K, Fuwa N, Kohno R, Sakuma I, Tohnai I

    Biomed Eng Online   11 ( 1 )   65   2012.9

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    Background: To improve the accuracy of catheter navigation, it is important to develop a method to predict shifts of carotid artery (CA) bifurcations caused by intraoperative deformation. An important factor affecting the accuracy of electromagnetic maxillofacial catheter navigation systems is CA deformations. We aimed to assess CA deformation in different head and neck positions.Methods: Using two sets of computed tomography angiography (CTA) images of six patients, displacements of the skull (maxillofacial segments), C1-C4 cervical vertebrae, mandible (mandibular segment), and CA along with its branches were analyzed. Segmented rigid bones around CA were considered the main causes of CA deformation. After superimposition of maxillofacial segments, C1-C4 and mandible segments were superimposed separately for displacement measurements. Five bifurcation points (vA-vE) were assessed after extracting the CA centerline. A new standardized coordinate system, regardless of patient-specific scanning positions, was employed. It was created using the principal axes of inertia of the maxillofacial bone segments of patients. Position and orientation parameters were transferred to this coordinate system. CA deformation in different head and neck positions was assessed.Results: Absolute shifts in the center of gravity in the bone models for different segments were C1, 1.02 +/- 0.9; C2, 2.18 +/- 1.81; C3, 4.25 +/- 3.85; C4, 5.90 +/- 5.14; and mandible, 1.75 +/- 2.76 mm. Shifts of CA bifurcations were vA, 5.52 +/- 4.12; vB, 4.02 +/- 3.27; vC, 4.39 +/- 2.42; vD, 4.48 +/- 1.88; and vE, 2.47 +/- 1.32. Displacements, position changes, and orientation changes of C1-C4 segments as well as the displacements of all CA bifurcation points were similar in individual patients.Conclusions: CA deformation was objectively proven as an important factor contributing to errors in maxillofacial navigation. Our study results suggest that small movements of the bones around CA can result in small CA deformations. Although patients' faces were not fixed properly during CT scanning, C1-C4 and vA-vE displacements were similar in individual patients. We proposed a novel method for accumulation of the displacement data, and this study indicated the importance of surrounding bone displacements in predicting CA bifurcation.

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  • Thermochemoradiation therapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases. Reviewed International journal

    Mitsudo K, Koizumi T, Iida M, Iwai T, Oguri S, Yamamoto N, Itoh Y, Kioi M, Hirota M, Tohnai I

    Int J Radiat Oncol Biol Phys   83 ( 5 )   e639 - e645   2012.8

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    PURPOSE: To evaluate the therapeutic results and histopathological effects of treatment with thermochemoradiation therapy using superselective intra-arterial infusion via the superficial temporal and occipital arteries for N3 cervical lymph node metastases of advanced oral cancer. METHODS AND MATERIALS: Between April 2005 and September 2010, 9 patients with N3 cervical lymph node metastases of oral squamous cell carcinoma underwent thermochemoradiation therapy using superselective intra-arterial infusion with docetaxel (DOC) and cisplatin (CDDP). Treatment consisted of hyperthermia (2-8 sessions), superselective intra-arterial infusions (DOC, total 40-60 mg/m(2); CDDP, total 100-150 mg/m(2)) and daily concurrent radiation therapy (total, 40-60 Gy) for 4-6 weeks. RESULTS: Six of 9 patients underwent neck dissection 5-8 weeks after treatment. In four of these 6 patients, all metastatic lymph nodes, including those at N3, were grade 3 (non-viable tumor cells present) or grade 4 (no tumor cells present) tumors, as classified by the system by Shimosato et al (Shimosato et al Jpn J Clin Oncol 1971;1:19-35). In 2 of these 6 patients, the metastatic lymph nodes were grade 2b (destruction of tumor structures with a small amount of residual viable tumor cells). The other 3 patients did not undergo neck dissection due to distant metastasis after completion of thermochemoradiation therapy (n=2) and refusal (n=1). The patient who refused neck dissection underwent biopsy of the N3 lymph node and primary sites and showed grade 3 cancer. During follow-up, 5 patients were alive without disease, and 4 patients died due to pulmonary metastasis (n=3) and noncancer-related causes (n=1). Five-year survival and locoregional control rates were 51% and 88%, respectively. CONCLUSIONS: Thermochemoradiation therapy using intra-arterial infusion provided good histopathologic effects and locoregional control rates in patients with N3 metastatic lymph nodes. However, patients with N3 metastatic lymph nodes experienced a high rate of distant metastases.

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  • An accurate maxillary superior repositioning technique without intraoperative measurement in bimaxillary orthognathic surgery Reviewed

    Omura S, Kimizuka T, Iwai T, Tohnai I

    Int J Oral Maxillofac Surg   41 ( 8 )   949 - 951   2012.8

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    This article describes a simple and accurate technique for maxillary superior repositioning without any intraoperative measurement using reference points that can be the source of error in bimaxillary orthognathic surgery. A bilateral straight locking miniplates (SLMs)/screw system secured to the maxilla and mandible maintains the three-dimensional relationship between the mandible and the skull base precisely like the incisor pin of an articulator in model surgery. The maxilla can then be accurately moved into the planned position identical to that in model surgery by the SLMs technique.

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  • Role of 3-Dimensional CT Angiography for Vascular Assessment. Reviewed

    Iwai T, Tohnai I, Yasumura K, Maegawa J

    23 ( 4 )   1223 - 1224   2012.7

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    File: Role of 3D.pdf

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  • Endoscopic removal of a maxillary third molar displaced into the maxillary sinus via the socket Reviewed

    Iwai T, Matsui Y, Hirota M, Tohnai I

    J Craniofac Surg   23 ( 4 )   E295 - E296   2012.7

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    Removal of a maxillary third molar is a common dental procedure, and oral surgeons rarely experience accidental displacement of a maxillary impacted third molar into the maxillary sinus as a complication of this procedure. In the case in which such displacement occurs, the molar is removed via a transantral (Caldwell-Luc) approach through bone removal or window osteotomy of the anterior wall of the maxillary sinus. However, this approach is highly invasive because 2 surgical fields are required at the socket and the anterior wall of the maxillary sinus. Here, we report as a minimally invasive approach endoscopic removal of a maxillary third molar displaced into the maxillary sinus via the socket.

    File: Endoscope extration.pdf

    DOI: 10.1097/SCS.0b013e318252f1cf

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  • Transzygomatic Kirschner wire fixation for the treatment of blowout fracture Reviewed

    Yasumura K, Mikami T, Yabuki Y, Ooishi K, Hosono M, Yamamoto Y, Iwai T, Maegawa J

    J Plast Reconstr Aesthet Surg   65 ( 7 )   875 - 882   2012.7

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    Background: Total orbital floor reconstruction with sheet-shape materials is available for the treatment of extensive and crushed-type blowout fractures. Simple blowout fractures, on the other hand, require only manual reduction without fixation. Although several types of blowout fractures do not require total reconstruction, some fixation is usually necessary.
    Methods: Eighteen cases of blowout fracture were treated with transzygomatic Kirschner wire fixation between 2002 and 2009. This technique was applied to simple fracture cases in which periorbital soft tissue re-herniated through the floor defect into the maxillary sinus after manual reduction, despite improvement of the extra-ocular muscle entrapment. The wire was used to directly support the fracture segment in five cases and used together with a maxillary sinus anterior wall bone graft in 13 cases.
    Results: Mean follow-up was 12.5 months. Mild diplopia remained as a subjective symptom in one case. None of the cases developed major complications or conspicuous scars on the cheek.
    Conclusions: Transzygomatic Kirschner wire fixation for blowout fracture has the advantages of precise and rigid fixation of all parts of the inferior floor, minimal morbidity without requiring an orbital approach and long-term safety without artificial remnants. This technique can be applied for the treatment of simple blowout fractures. (C) 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

    File: K-wire.pdf

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  • Incidence of the occipital artery arising from the internal carotid artery identified by three-dimensional computed tomographic angiography Reviewed

    Iwai T, Izumi, T, Inoue T, Maegawa J, Mitsudo K, Tohnai I

    Br J Oral Maxillofacial Surg   50 ( 4 )   373 - 375   2012.6

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    Variants of the branches of the external carotid artery are common, but it is extremely rare that the occipital artery arises from the internal carotid artery. We investigated the incidence using three-dimensional computed tomographic (CT) angiography. In 265 patients with cancer of the head and neck, we did CT angiography for vascular mapping of the external carotid artery and its branches before reconstruction or superselective intra-arterial chemotherapy. The origin of the occipital artery was detected in 514 of 530 carotid arteries (97%); the incidence of it arising from the internal carotid artery was 0.2%. (C) 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

    File: OA incidence.pdf

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  • Occipital artery arising from the anterior aspect of the internal carotid artery identified by three-dimensional computed tomography angiography. Reviewed International journal

    Toshinori Iwai, Toshiharu Izumi, Tomio Inoue, Jiro Maegawa, Nobukazu Fuwa, Kenji Mitsudo, Iwai Tohnai

    Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society   9 ( 2 )   103 - 105   2012.6

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    Variation of the branches of the external carotid artery (ECA) is well known, but it is extremely rare for the occipital artery (OA) to arise from the internal carotid artery (ICA). A 87-year-old man was found to have this anatomical variation on the right side by threedimensional computed tomography angiography for vascular mapping of the carotid arteries before superselective intra-arterial catheterization for advanced tongue cancer. Imaging showed the OA arose from the anterior aspect of the right ICA with the origin located 8.8 mm distal from the carotid bifurcation. The inner diameter of the origin of the OA was 2.1 mm and the angle between the OA and the ICA was 62 degrees. It is important to recognize this anatomic variation of the branches of the ECA before head and neck microsurgical reconstruction or superselective intra-arterial chemotherapy for oral cancer.

    File: OA ICA.pdf

    DOI: 10.5812/iranjradiol.7809

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  • Le Fort I osteotomy under navigational guidance for posterior repositioning of the maxilla Reviewed

    Iwai T, Matsui Y, Omura S, Tohnai I

    J Craniofac Surg   23 ( 6 )   e619 - e621   2012.6

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    File: Le_Fort_I_Osteotomy_Under_Navigational_Guidance.70.pdf

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  • Net effect of lymphaticovenous anastomosis on volume reduction of peripheral lymphoedema after complex decongestive physiotherapy Reviewed

    Maegawa J, Hosono M, Tomoeda H, Tosaki A, Kobayashi S, Iwai T

    Eur J Vasc Endovasc Surg   43 ( 5 )   602 - 608   2012.5

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    Objective: The results of reported lymphaticovenous anastomoses include some effects of complex decongestive physiotherapy (CDP). The present study aimed to determine the net effect of lymphaticovenous side-to-end anastomosis (LVSEA) in patients with lower limb lymphoedema treated by preoperative CDP.
    Design: Retrospective observational study.
    Materials: 37 LVSEAs in 31 patients.
    Methods: Volumes of the thigh and leg with oedema were compared between the time of initial examination, and before (application of CDP) and after LVSEA. The patients were divided into two groups based on the number of anastomoses and lymphoscintigraphic findings.
    Results: Preoperative CDP resulted in a reduction of 593 ml (both leg and thigh; p &lt; 0.001). After CDP, LVSEA (1-8 anastomoses; average of 5) reduced the volume by 109 ml (52 ml for the thigh (p = 0.01) and 57 ml for the leg (p,= 0.002)). There was no significant difference in volume reduction on lymphoscintigraphy. Volume was significantly reduced (by 55 ml in the, thigh, p = 0.049; 96 ml in the leg, p = 0.006) in the group that underwent 6-8. but not 1-5 LVSEAs.
    Conclusions: The net effect of LVSEA on volume reduction was confirmed, but was not particularly large. The need for CDP decreased in some patients postoperatively, and these patients should be considered for evaluation. (C) 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

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  • Endoscopic removal of bilateral supernumerary intranasal teeth Reviewed

    Iwai T, Aoki N, Yamashita Y, Omura S, Matsui Y, Maegawa J, Tohnai I

    J Oral Maxillofac Surg   70 ( 5 )   1030 - 1034   2012.5

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    File: supernumerary.pdf

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  • Blepharoplasty in senile blepharoptosis: Preoperative measurements and design for skin excision Reviewed

    Maegawa J, Kobayashi S, Yabuki Y, Hirotomi K, Yasumura K, Iwai T

    Aesthet Surg J   32 ( 4 )   441 - 446   2012.5

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    Background: For patients with senile ptosis, aesthetic blepharoplasty can be combined with ptosis surgery. However, the amount of skin excision necessary in blepharoplasty is not clearly defined by measurements of the upper eyelids.
    Objectives: The authors preoperatively evaluate the amount of skin to be excised in blepharoplasty.
    Methods: Fifty patients with bilateral senile ptosis were included in this study. The amount of skin to be excised from the upper eyelids was selected based on preoperative measurements of redundant skin, equivalent to the maximum lid height (MLH) while manually stretching the eyelid upwards minus resting lid height (RLH) with the eyes closed passively. Ptosis surgery (such as plication of the aponeurosis) followed blepharoplasty.
    Results: Preoperatively, mean MLH was 35 mm on the right and 36 mm on the left. Mean RLH was 25 mm bilaterally. The mean amount (height) of excised skin was 10 mm on the right and 11 mm on the left. At six months postoperatively, mean MLH and RLH were 29 and 23 mm on both sides, respectively. Significant differences between pre- and postoperative MLH and RDH were seen on both sides (P &lt; .001). No complications due to overexcision were observed, but revision was performed for two patients with asymmetry of the lid folds and five patients with recurrence of drooping.
    Conclusions: Preoperative measurements of upper eyelid heights (stretched and at rest) appear useful in determining the amount of skin excision required in blepharoplasty for senile ptosis.

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  • Use of in-house, full-colour printed three-dimensional model for training in endoscopic periradicular surgery for molar radicular cyst Reviewed

    Iwai T, Tamai N, Matsui Y, Tohnai I

    Br J Oral Maxillofac Surg   50 ( 3 )   E41 - E42   2012.4

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    File: 3D model.pdf

    DOI: 10.1016/j.bjoms.2011.08.013

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  • Thyrolingual trunk arising from the common carotid artery identified by three-dimensional computed tomography angiography Reviewed

    Iwai T, Izumi T, Inoue T, Maegawa J, Fuwa N, Mitsudo K, Tohnai I

    Surg Radiol Anat   34 ( 1 )   85 - 88   2012.1

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    It is well-known that the branches of the external carotid artery (ECA) can show anatomical variation, but it is extremely rare that thyrolingual trunk originates from common carotid artery (CCA). Here we report a case of the thyrolingual trunk arising from the CCA on the right side in a 73-year-old female as revealed by three-dimensional computed tomography angiography for vascular mapping of the carotid vessels before head and neck microsurgical reconstruction. The thyrolingual trunk arose from the anterior surface of the right CCA, with an origin 14.5 mm (difference between the carotid bifurcation and upper border of the origin 12.7 mm) below the carotid bifurcation. The inner diameter of origin of the thyrolingual trunk was 3.5 mm, and the angle between the thyrolingual trunk and the CCA was 130A degrees. After a 10.2-mm course, the thyrolingual trunk divided into the superior thyroid artery (STA) and lingual artery (LA). The inner diameters of the origins of the STA and LA were 1.7 and 1.9 mm, respectively, and the angle between the branches was 94A degrees. It is important to recognize this anatomic variation of the branches of the ECA before the microsurgical reconstruction or super-selective intra-arterial chemotherapy for head and neck cancer.

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  • Anatomical study of the external carotid artery and its branches for administration of superselective intra-arterial chemotherapy via the superficial temporal artery Reviewed

    Yonenaga K, Tohnai I, Mitsudo K, Mori Y, Saijo H, Iwai T, Yonehara Y, Ota Y, Torigoe K, Takato T

    Int J Clin Oncol   16 ( 6 )   654 - 659   2011.12

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    The branching patterns of the external carotid artery vary among individuals, and consideration of the proximity of nerves is important during catheter insertion in superselective intra-arterial infusion via the superficial temporal artery. We aimed to evaluate the anatomy of the external carotid artery and its surrounding nerves for safe and accurate administration of superselective intra-arterial chemotherapy via the superficial temporal artery.
    We analyzed the external carotid artery and its branches morphometrically in 28 Japanese cadavers (56 sides).
    Vascular tortuosity in the preauricular region of the catheter insertion site was observed in 42.9% of the sides; the main trunk of the external carotid artery was excessively tortuous in 25.0% of the sides, primarily in the preparotid region. Faciolingual and superior thyrolingual trunks were observed in 28.6 and 1.8% of the sides, respectively. The superior thyroid, lingual, facial, occipital, and maxillary arteries branched from the external carotid artery above the carotid bifurcation in 41.1% of the sides. The mean distance between the insertion site and maxillary artery was 39.5 mm, indicating the extent of catheter insertion. The auriculotemporal nerve was observed near the superficial temporal artery in the preauricular region in 44.6% of the sides; however, the clearly identifiable nerves in the exposed area were difficult to avoid.
    Because of the branching variations observed in individuals and sides, preoperative angiography is extremely important for avoiding complications.

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  • Use of methylene blue for precise peripheral ostectomy of keratocystic odontogenic tumour Reviewed

    Iwai T, Hirota M, Maegawa J, Tohnai I

    Br J Oral Maxillofac Surg   49 ( 8 )   E84 - E85   2011.12

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  • Use of a hydrocolloid dressing to prevent nasal pressure sores after nasotracheal intubation Reviewed

    Iwai T, Goto T, Maegawa J, Tohnai I

    Br J Oral Maxillofac Surg   49 ( 7 )   E65 - E66   2011.10

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  • Intravascular catheter navigation using path planning and virtual visual feedback for oral cancer treatment Reviewed

    Wang J, Ohya T, Liao H, Sakuma I, Wang T, Tohnai I, Iwai T

    Int J Med Robot   7 ( 2 )   214 - 224   2011.6

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    Background It is tedious and difficult to position a flexible catheter in a target vessel branch within complicated-shaped vessels owing to the lack of real-time visual feedback. Digital subtraction angiography and fluoroscopic guidance are currently used for catheter placement.
    Methods The proposed method employs an electromagnetic (EM) tracking system to track a sensor-attached catheter. Vessel centerlines are extracted from the CT angiography image, based on which a navigational information tree is built to facilitate catheter manipulation. A virtual endoscopy technique is adopted to generate virtual intravascular video as visual feedback. Unscented Kalman filtering based image registration is performed to align the EM tracker frame with the anatomical atlas and to envision the target registration error.
    Results Preliminary experimental results showed the feasibility and effectiveness of the newmethod, with navigation accuracy of 1.80 +/- 0.85 mm.
    Conclusions The proposed method can provide continuous virtual visual feedback to facilitate catheter placement and has the potential for clinical use, with significant reduction in X-ray radiation exposure and doses of contrast agents. Copyright (C) 2011 John Wiley & Sons, Ltd.

    File: Wang_et_al-2011-The_International_Journal_of_Medical_Robotics_and_Computer_Assisted_Surgery.pdf

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  • Epithelial inclusion cyst after intermaxillary screw placement: A case report Reviewed

    Adachi M, Matsui Y, Iwai T, Hirota M, Uezono M, Masuda G, Maegawa J, Tohnai I

    J Oral Maxillofac Surg   69 ( 4 )   1117 - 1119   2011.4

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  • オトガイ形成術の2時間後に気道閉塞を併発した1症例(Airway Obstruction Complicated by Genioplasty Developing 2 Hours after Surgery)

    青木 紀昭, 山下 陽介, 長谷川 幸生, 宮崎 千佳, 岩井 俊憲, 村田 彰吾, 松井 義郎, 藤内 祝

    日本口腔診断学会雑誌   24 ( 1 )   150 - 154   2011.2

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    われわれはオトガイ形成術後の2時間に気道閉塞を併発した極めて稀な1症例を経験したので報告する。患者は20歳女性で顎変形症でオトガイ形成術を施行し、術後約2時間経過し重篤な気道閉塞を併発した。緊急で再挿管を必要とし集中治療室で4日間の全身管理を必要とした。(著者抄録)

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  • Primary sebaceous carcinoma of the tongue Reviewed

    Oshiro H, Iwai T, Hirota M, Mitsudo K, Tohnai I, Minamimoto R, Omura-Minamisawa M, Nagashima Y, Yamanaka S, Fukui T, Kanazawa M, Sagawa H, Mita K, Nakayama T, Inayama Y

    Med Mol Morphol   43 ( 4 )   246 - 252   2010.12

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    Sebaceous carcinoma is the rarest type of oral malignancies. We report a case of primary sebaceous carcinoma of the tongue. Systemic imaging studies revealed that the patient had a T2N2cM0 (International Union Against Cancer guidelines) primary lingual tumor. Histopathological examination revealed neoplastic sebocytic and basaloid cells, and Sudan III staining and electron microscopy revealed intracytoplasmic lipid droplets. The neoplastic cells stained positive for adipophilin; epithelial membrane antigen; epithelial antigen; and cytokeratins 7, 8, and 15, but negative for cytokeratins 5/6, 18, 19, and 20; the androgen receptor; and carcinoembryonic antigen. Superselective intraarterial chemotherapy was administered via the superficial temporal artery concurrent with daily radiotherapy. Multiple biopsies confirmed a complete response of the primary lesion. The patient then underwent neck dissection followed by pathological examination, which revealed lymph nodes metastases. After postoperative radiotherapy to the neck, distant metastases were identified in the mediastinal lymph nodes and the lung. The patient died 17 months after completing the initial course of chemoradiotherapy. Our case demonstrates that superselective intraarterial chemotherapy combined with concurrent radiotherapy can be effective in treating the primary lesion of patients with a sebaceous carcinoma of the tongue. However, an effective strategy to eradicate metastases has yet to be established.

    File: Sebaceous ca.pdf

    DOI: 10.1007/s00795-010-0521-4

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  • 新しい接着性顎間固定用アーチバーの臨床的応用(Clinical Application of a New "Pre-bent and Direct Bonded Arch Bar" for Maxillomandibular Fixation)

    青木 紀昭, 長谷川 幸生, 山下 陽介, 大村 進, 岩井 俊憲, 藤内 祝

    日本口腔診断学会雑誌   23 ( 2 )   360 - 365   2010.10

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    顎骨骨折の治療に対しアーチバーを使った顎間固定は必要不可欠である。そのため近年種々のアーチバーが開発されている。しかし歯肉炎、装着時の患者への疼痛、不快感、装着の煩雑さ、術者への感染のリスクなど多くの欠点がある。そのため、直径1.0mmのステンレスワイヤーを主線として直径0.7mmの長4mmのワイヤーをろう着した新しいタイプの接着性顎間固定用アーチバーを開発した。今回われわれは、2007年より2010年まで顎骨骨折15症例にこの新しいタイプのアーチバーを応用し良好な結果が得られたので報告する。(著者抄録)

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  • Management considerations for the patient with tongue squamous cell carcinoma associated with Behçet's disease: A case report Reviewed

    Makoto Adachi, Kenji Mitsudo, Makoto Hirota, Shinsuke Ohta, Kei Watanuki, Toshinori Iwai, Yoshihito Ohhara, Yoshiro Matsui, Iwai Tohnai

    Asian Journal of Oral and Maxillofacial Surgery   22 ( 1 )   43 - 46   2010.7

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    Malignancies associated with Behçet's disease (BD) are rare, and surgery for patients with BD frequently results in postoperative complications such as wound dehiscence, postoperative infection, and exacerbation of BD itself. We present a rare case of left tongue carcinoma in a 70-year-old woman with BD. The pathological findings showed moderate-differentiated squamous cell carcinoma with atypical squamous cell infiltrative proliferation. Daily concurrent chemoradiotherapy with docetaxel and cisplatin using superselective intra-arterial infusion via superficial temporal artery and occipital artery was performed. Two indwelling catheters, one from the left occipital artery to the left lingual artery and the other from the left superficial temporal artery to the left facial artery, were inserted to carry out superselective intra-arterial infusion treatment. After completion of all treatments, a biopsy specimen of the primary lesion showed grade III, nonviable tumor cells, suggesting complete response. Superselective intra-arterial chemoradiotherapy was effective for treating the tongue carcinoma associated with BD, and avoided surgical treatment. This method could control the primary lesion and cervical lymph node metastasis clinically without severe side effects. The patient has been disease free for 18 months without the complication of treatment. © 2010 Asian Association of Oral and Maxillofacial Surgeons.

    File: Bechet.pdf

    DOI: 10.1016/j.ajoms.2009.07.003

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  • Three-dimensional visualization of the relationship between cervical cystic lesions and related vessels using CT angiography for endoscopically-assisted neck surgery Reviewed

    Iwai T, Matsui Y, Tohnai I, Mikami T, Maegawa J

    J Plast Reconstr Aesthet Surg   63 ( 1 )   E82 - E83   2010.1

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    File: 3DCTA endoscope.pdf

    DOI: 10.1016/j.bjps.2009.01.044

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  • Mandibular reconstruction using 2-step bone transport in an irradiated cancer patient with type 2 diabetes mellitus Reviewed

    Matsui Y, Shirota T, Iwai T, Ozawa T, Watanuki K, Hirota M, Tohnai I, Maegawa J

    Int J Oral Maxillofac Surg   38 ( 11 )   1223 - 1225   2009.11

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    This report describes mandibular reconstruction using a 2-step bone transport technique in a cancer patient with type 2 diabetes mellitus (DM) who received radiotherapy before ablative surgery. The bone, measuring 90 mm in length with the mandibular curvature and good alveolar form, was regenerated using a plate-guided method. Three implants were placed 21 months after completion of the first distraction and 14 months after the second distraction. These implants integrated successfully and have remained stable more than 2 years after loading. The results suggest that mandibular reconstruction using bone transport is possible after segmental osteotomy in irradiated cancer patients with DM, although a long treatment period is required.

    File: Mandibular reconstruction.pdf

    DOI: 10.1016/j.ijom.2009.06.027

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  • Temporary alopecia caused by pressure from a headband used to secure a reference frame to the head during navigational surgery. Reviewed International journal

    Iwai T, Matsui Y, Hirota M, Tohnai I, Maegawa J

    Br J Oral Maxillofac Surg   47 ( 7 )   573 - 574   2009.10

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    File: alopecia.pdf

    DOI: 10.1016/j.bjoms.2009.02.019

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  • Simple technique to identify Wharton's duct during endoscopically-assisted submandibular sialoadenectomy. Reviewed International journal

    Iwai T, Matsui Y, Hirota M, Chikumaru H, Mitsudo K, Maegawa J, Tohnai I

    Br J Oral Maxillofac Surg   47 ( 5 )   401 - 402   2009.7

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    File: SMG removal.pdf

    DOI: 10.1016/j.bjoms.2008.09.001

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  • Simple technique for dilatation of the papilla in sialoendoscopy. Reviewed International journal

    Iwai T, Matsui Y, Yamagishi M, Hirota M, Mitsudo M, Maegawa M, Tohnai I

    J Oral Maxillofac Surg   67 ( 3 )   681 - 682   2009.3

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    File: Sialendoscopy.pdf

    DOI: 10.1016/j.joms.2008.08.043

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  • Evaluation of maxillary sinus floor augmentation using mixture of autogenous bone and highly pure porous β-tricalcium phosphate (β-TCP): A preliminary study Reviewed

    Makoto Hirota, Yoshiro Matsui, Nobuyuki Mizuki, Kei Watanuki, Tomomichi Ozawa, Toshinori Iwai, Iwai Tohnai

    Journal of Hard Tissue Biology   18 ( 2 )   83 - 88   2009

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    The aim of this study was to reveal the efficacy of autogenous bone mixed with β-TCP. The mixtured graft materials at the maxillary sinus floor were observed. Sinus floor augmentation with autogenous bone and β-TCP was performed at six sites in three patients. The grafted site was observed with computed tomography (CT) at one, six and twelve months. The height and Hounsfield units (HU) of graft tissues were calculated using SIMplant. Dental implant surgery was then performed. The increasing height of graft tissue at one month was approximately 13 mm and showed 20% reduction at twelve months. Approximately 10 mm bone height was gained before implant surgery. The mean HU at six months showed the bone level HU. The HU at one month was reduced at six months and slightly increased mainly at the center of graft tissue at twelve months. At implant surgery, initial stability was adequate. The mixture of autogenous bone and β-TCP played a sufficient role for sinus floor augmentation, and it could be possible to reduce bone harvesting by using β-TCP. © 2009 The Hard Tissue Biology Network Association.

    File: Sinus floor.pdf

    DOI: 10.2485/jhtb.18.83

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  • Efficacy of tooth extraction wound protection made of atelocollagen sponge (TRE-641): A pilot study in dogs Reviewed

    Hirota M, Mizuki N, Aoki S, Omura S, Watanuki K, Ozawa T, Iwai T, Matsui Y, Tohnai I

    J Hard Tissue Biol   18 ( 2 )   89 - 94   2009

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    To evaluate the efficacy of tooth extraction wound protection made of atelocollagen sponge (TRE-641), we observed healing in tooth extraction sites filled with TRE-641 and those filled with a control material, oxide cellulose. Subjects were 11 beagle dogs, with a total of 22 extraction sites. Both maxillary lateral incisors were carefully removed, and extraction wounds were filled with TRE-641 on one side and with oxidized cellulose sponge as control on the other side. Wound healing was observed, and the animals were sacrificed at 7, 14, and 28 days after surgery. We compared extent of bone formation, hematoma, inflammation, and graft material remaining between the two groups. At 7 days, newly formed bone extending from the floor and wall of the socket bone were seen in the TRE-641. Hematoma and inflammation were observed in the oxide cellulose. At 14 days, a small amount of TRE-641 remained. In the oxide cellulose group, a small amount of hematoma remained. At 28 days, the extraction socket was filled with newly formed bone in both groups. TRE-641 produced acceptable early phase bone healing at the tooth extraction site with no remnant graft material with sufficient bone formation of the tooth extraction wound. © 2009 The Hard Tissue Biology Network Association.

    File: TRE.pdf

    DOI: 10.2485/jhtb.18.89

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  • Combination with allogenic bone reduces early absorption of β-tricalcium phosphate (β-TCP) and enhances the role as a bone regeneration scaffold. Experimental animal study in rat mandibular bone defects Reviewed

    Hirota M, Matsui Y, Mizuki M, Kishi T, Watanuki K, Ozawa T, Fukui T, Shoji S, Adachi M, Monden Y, Iwai T, Tohnai I

    Den Mater J   28 ( 2 )   153 - 161   2009

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    β-tricalcium phosphate (β-TCP) was grafted into rat mandibular bone defects to assess its potential as a scaffold material for bone regeneration. For this purpose, β-TCP (TCP), allogenic bone (Allograft), and allogenic bone combined with β-TCP (Combined) were employed as graft materials. To the left side of the graft materials in the bone defects, platelet-rich plasma (PRP) was added. The rats were sacrificed at one, three, and five weeks. Bone formation rate (BFR), remaining β-TCP rate (RTR), β-TCP absorption rate (TAR), whole amount of β-TCP (WTCP), and total rate of BFR and RTR (TBR) were measured. Combined showed equivalent BFR to Allograft at five weeks, and showed higher RTR at one week and higher BFR at five weeks than TCP. Combined with PRP showed higher TAR than that without PRP at three weeks. Therefore, combination with allogenic bone showed reduced β-TCP absorption, hence enhancing the role of β-TCP in bone regeneration. These findings suggested that β-TCP is a better scaffold for bone regeneration if its early absorption is reduced when used in combination with an osteogenic material.

    File: Combination allo.pdf

    DOI: 10.4012/dmj.28.153

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  • Endoscopic-assisted medial osteotomy during sagittal split ramus osteotomy Reviewed

    Iwai T, Matsui Y, Tohnai I, Maegawa J

    J Plast Reconstr Aesthet Surg   61 ( 12 )   1547 - 1548   2008.12

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    File: EBSSO.pdf

    DOI: 10.1016/j.bjps.2008.03.057

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  • Management considerations in reconstruction of postablative defects of the mandible: vertical distraction of a scapular bone flap and removable lip support: a case report. Reviewed International journal

    Hirota M, Matsui Y, Mizuki N, Saito T, Watanuki K, Iwai T, Tohnai I

    Oral Surg Oral Med Oral Pathol Oral Radiol Endod   106 ( 6 )   e6 - e9   2008.12

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    OBJECTIVE: To describe vertical distraction osteogenesis of a scapular flap and removable lip support for oral rehabilitation after surgical creation of an ablative defect of the mandible. CASE REPORT: A 70-year-old man who was diagnosed with squamous cell carcinoma of the left lower gingiva underwent segmental mandibulectomy for tumor ablation and reconstruction with a scapular bone flap. To augment bone height of this flap, vertical distraction osteogenesis was performed. After denture fabrication, a removable lip support was placed between the implant-supported denture and the lower lip. RESULTS: The bone height of the scapular bone flap increased by 9 mm. Implants with adequate length could be placed in the distracted bone. The lip support was effective. Two years after masticatory loading, the implants remained stable. CONCLUSION: Vertical distraction osteogenesis of the scapular bone flap was suitable to facilitate postoperative functional and esthetic restoration after tumor resection. A removable lip support was also useful as a supplementary tool for oral rehabilitation.

    File: Management.pdf

    DOI: 10.1016/j.tripleo.2008.05.048

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  • Osteosynthesis and simultaneous irregular trifocal distraction osteogenesis for segmental mandibular defect after tumor ablative surgery: a case report. Reviewed International journal

    Hirota M, Chikumaru H, Matsui Y, Adachi M, Aoki S, Watanuki K, Ozawa T, Iwai T, Tohnai I

    Oral Surg Oral Med Oral Pathol Oral Radiol Endod   106 ( 5 )   651 - 655   2008.11

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    OBJECTIVE: This paper describes a case of secondary mandibular bone reconstruction performed to place dental implants. Osteosynthesis and simultaneous irregular trifocal distraction osteogenesis were documented. PATIENT: The patient was a 51-year-old man with recurrent ameloblastoma of the mandible. Segmental mandibulectomy for tumor ablation and immediate mandibular reconstruction were performed. Because the volume of reconstructed bone was insufficient to place dental implants, trifocal distraction osteogenesis (vertical and horizontal distraction osteogenesis) was performed. Because the mandible had lost its continuity, osteosynthesis was performed simultaneously. RESULTS: Through this procedure, the bone was well augmented. Absorption of the distracted bone was not seen. Adequate-length implants were placed. CONCLUSION: Irregular trifocal distraction osteogenesis synchronized with osteosynthesis shortened the treatment period and produced stable bone augmentation for placement of dental implants. Therefore, this procedure could be indicated for complicated segmental mandibular bone defects.

    File: Osteosynthesis.pdf

    DOI: 10.1016/j.tripleo.2008.03.013

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  • Endoscopically-assisted resection of a branchial cyst Reviewed

    Matsui Y, Iwai T, Tohnai I, Maegawa J

    Br J Oral Maxillofac Surg   46 ( 4 )   336 - 337   2008.6

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    File: Branchial cyst.pdf

    DOI: 10.1016/j.bjoms.2007.11.002

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  • Vertical distraction of a free vascularized osteocutaneous scapular flap in the reconstructed mandible for implant therapy Reviewed

    Hirota M, Mizuki N, Iwai T, Watanuki K, Ozawa T, Maegawa J, Matsui Y, Tohnai I

    Int J Oral Maxillofac Surg   37 ( 5 )   481 - 483   2008.5

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    This paper describes a case of vertical distraction osteogenesis of a free vascularized osteocutaneous scapular flap in the reconstructed mandible before implant therapy. The patient was a 67-year-old woman with squamous cell carcinoma of the right lower gingiva. She underwent segmental mandibulectomy for tumor ablation and reconstruction with an osteocutaneous scapular flap. The distraction protocol, clinical course and implant therapy are presented. Through this procedure, the bone height of the scapular graft increased by 10 rum. Implants with adequate length could be placed in the distracted area. Two years after masticatory loading, the condition of these implants was stable. Vertical distraction osteogenesis of the scapular flap was considered effective when performed before implant therapy, to facilitate postoperative functional and esthetic restoration after tumor resection.

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    DOI: 10.1016/j.ijom.2008.01.002

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  • Salivary duct carcinoma in the mandible: a case report Reviewed

    Kikuchi Y, Hirota M, Iwai T, Aoki S, Chikumaru H, Kawabe R, Matsui Y

    Oral Surg Oral Med Oral Pathol Oral Radiol Endod   103 ( 3 )   E41 - E46   2007.3

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    Salivary duct carcinoma (SDC) is a distinctive and aggressive neoplasm. The most frequent site of origin is the parotid gland, followed by the submandibular gland. SDC originating in the minor salivary glands, particularly in the ectopic glands within the mandible, is extremely rare. We describe a 62-year-old man with SDC in the mandible, who presented with a painless lump in the right submandibular region (later identified as lymph node metastasis) and ipsilateral mental nerve palsy. Histologic examination after ablative surgery revealed SDC originating in the mandible and cervical nodal metastases spreading to levels I-III. The patient remains alive 59 months after presentation as a result of postoperative full-dose irradiation and regular intensive chemotherapy using TXT, 5-FU, and CDDP. However, the patient has local recurrence and distant metastases to the lung and brain. In this report, we also discuss the specific diagnostic criteria and developmental theories of intraosseous salivary gland tumors.

    File: SDC.pdf

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Books

  • AO法骨折治療 アドバンスト頭蓋顎顔面手術

    岩井俊憲( Role: Joint translator頭蓋顎顔面手術における3D製造技術とその応用,頭蓋顎顔面再建術におけるナビゲーションとコンピュータプランニング-序論 ,画像解析:データ取得と処理,仮想モデルとデータ抽出)

    医学書院  2023.11 

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  • 一般臨床家,口腔外科のための口腔外科ハンドマニュアル’22

    岩井俊憲( Role: Contributor口腔顎顔面領域における良性疾患に対する内視鏡支援下手術(pp.28-33))

    クインテッセンス出版  2022.7 

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  • Medical Practice

    岩井俊憲, 杉山聡美( Role: Contributor耳鼻咽喉科的 minor emergency 唾石症の急性発作(39巻(臨時増刊号)pp.219-220))

    文光堂  2022.4 

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  • JOHNS

    岩井俊憲, 杉山聡美( Role: Contributor私はこうしている-口腔咽喉頭頸部手術編.【口腔・咽頭手術】唾石摘出術(35巻9号 pp.1041-1043))

    東京医学社  2019.9 

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  • INNERVISION SOMATOM Symposium 2018 Report

    岩井俊憲( Role: ContributorNew 3D mapping of sentinel lymph node in oral cancer(33巻11号別冊 pp.8-9))

    インナービジョン  2018.11 

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  • 臨床画像

    藤内 祝, 岩井俊憲, 小泉敏之, 光藤健司( Role: Contributor【口腔癌領域における放射線治療に役立つ知識】進行舌癌に対する動注化学放射線療法(34巻11号 pp.1309-1317))

    MEDICAL VIEW  2018.11 

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  • JOHNS

    岩井俊憲, 杉山聡美( Role: Contributor手術に必要な画像診断-口腔・咽頭編 唾石摘出術(34巻5号 pp.561-566))

    東京医学社  2018.5 

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  • 一般臨床家,口腔外科のための口腔外科ハンドマニュアル’16

    岩井俊憲, 藤内 祝( Role: Contributor内視鏡下唾石摘出術(pp.180-185))

    クインテッセンス出版  2016.7 

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  • Dental Diamond

    松井義郎, 岩井俊憲, 廣田 誠, 光藤健司, 藤内 祝( Role: Contributor口腔外科領域における内視鏡支援下手術-ミニマルインターベンション(MI)を目指して(34巻12号 pp.74-79))

    クインテッセンス出版  2009.12 

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MISC

  • 未治療の閉塞性睡眠時無呼吸を合併し術後に心肺停止に至った顎下腺唾石症の一例 Reviewed

    矢島康治, 岩井俊憲, 田中宏幸, 杉山聡美, 石川聡一郎, 出田ゆか, 四戸希久世, 吉井 悠, 林 雄一郎, 大橋伸英, 小栗千里, 光藤健司

    横浜医学   75 ( 4 )   559 - 564   2024.12

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    File: 05 Yajima.pdf

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  • 下顎枝矢状分割術の術後にプレート破折が生じた3症例-プレート破折要因の検討- Reviewed

    南山周平, 岩井俊憲, 杉山聡美, 矢島康治, 本田康二, 光藤健司

    横浜医学   75 ( 1 )   7 - 12   2024.1

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    File: 02_Minamiyama.pdf

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  • 舌下部に生じた側方型類皮囊胞の1例 Reviewed

    馬場隼一, 岩井俊憲, 南山周平, 杉山聡美, 吉井 悠, 北島大朗, 矢島康治, 小栗千里, 山中正二, 光藤健司

    横浜医学   74 ( 4 )   585 - 589   2023.11

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    File: 舌下部に生じた側方型類皮囊胞の1例.pdf

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  • ナビゲーションシステムを用いて摘出した上顎歯原性角化嚢胞再発症例 Reviewed

    矢谷実英, 岩井俊憲, 杉山聡美, 石川総一郎, 出田ゆか, 吉井 悠, 南山周平, 矢島康治, 馬場隼一, 小栗千里, 光藤健司

    横浜医学   74 ( 2 )   43 - 47   2023.4

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    File: 03_Yatani.pdf

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  • ナビゲーションシステムと二分割サージカルガイドを用いて骨削除術を行った下顎骨線維性異形成症の1例 Reviewed

    矢島康治, 岩井俊憲, 本田康二, 杉山聡美, 石川総一郎, 出田ゆか, 矢谷実英, 南山周平, 馬場隼一, 大橋伸英, 片岡俊朗, 藤井誠志, 光藤健司

    横浜医学   73 ( 2 )   47 - 53   2022.6

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    File: 04_YajimaMD.pdf

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  • ゴールから始める顎骨再建-computer assisted mandibular reconstruction- Invited Reviewed

    岩井俊憲

    日口外誌   68 ( 3 )   140 - 143   2022.3

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    File: ゴールから始める顎骨再建.pdf

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  • 成人に生じた顎下部リンパ管奇形の1例 Reviewed

    南山周平, 岩井俊憲, 杉山聡美, 石川総一郎, 出田ゆか, 吉井 悠, 矢島康治, 馬場隼一, 小栗千里, 光藤健司

    日口診誌   35 ( 1 )   29 - 34   2022.2

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    File: 成人に生じた顎下部リンパ管奇形の1例.pdf

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  • 口腔癌に対するセンチネルリンパ節生検 Invited Reviewed

    岩井俊憲, 杉山聡美, 藤内 祝, 光藤健司

    日歯医師会誌   74 ( 8 )   33 - 38   2021.11

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    File: クリニカル2(岩井俊憲様) 日本歯科医師会雑誌21年11月号.pdf

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  • 口内法による開窓術が奏功した耳下腺貯留嚢胞の1例 Reviewed

    馬場隼一, 岩井俊憲, 杉山聡美, 出田ゆか, 竹田 敦, 光藤健司

    日口外誌   67 ( 6 )   395 - 398   2021.6

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    File: 耳下腺貯留嚢胞.pdf

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  • 舌部分切除後の舌前方欠損に対してsliding tongue flapを用いて再建した1例 Reviewed

    竹田 敦, 岩井俊憲, 杉山聡美, 出田ゆか, 石川総一郎, 光藤健司

    日口外誌   67 ( 6 )   399 - 403   2021.6

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    File: STF.pdf

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  • 小児に生じた唾石症の臨床的検討 Reviewed

    北島大朗, 岩井俊憲, 石黒敬大, 杉山聡美, 大澤昂平, 光藤健司

    日口外誌   67 ( 5 )   258 - 264   2021.5

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    File: 小児唾石症.pdf

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  • 急性炎症により導管から逸脱した耳下腺唾石症の1例 Reviewed

    上田 潤, 岩井俊憲, 杉山聡美, 大橋伸英, 矢島康治, 馬場隼一, 小栗千里, 佐久間 要, 戸谷収二, 光藤健司

    日口診誌   34 ( 1 )   20 - 24   2021.2

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  • 下顎歯肉扁平上皮癌治療後早期に肝門部リンパ節転移と腹膜播種性転移を認めた1例

    小栗 千里, 出田 ゆか, 杉山 聡美, 林 雄一郎, 南山 周平, 岩井 俊憲, 小泉 敏之, 廣田 誠, 光藤 健司

    日本口腔腫瘍学会誌   31 ( 2 )   97 - 103   2019.6

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    頭頸部悪性腫瘍において遠隔転移は最も予後に影響する因子である。今回、われわれは肝門部リンパ節転移と腹膜播種性転移に至った。まれな下顎歯肉癌症例を経験した。患者は69歳、男性。右側下顎歯肉扁平上皮癌(T4aN3M0)に対し超選択的動注化学放射線治療を施行した。治療後1ヵ月でのFDG-PET/CT検査で肝門部リンパ節腫大を認めた。その後、腹水を伴う腹膜播種性転移を認めたため入院したが急速に全身状態が悪化し多臓器不全にて死亡した。病理解剖検査の結果、肝門部リンパ節腫大と腹膜播種性転移はいずれも右側下顎歯肉癌の転移であると診断された。(著者抄録)

    File: 播種性転移.pdf

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  • 顎変形症治療コンセンサスミーティングにおけるアンケート調査

    岩井 俊憲, 竹信 俊彦, 管野 貴浩, 山内 健介, 大井 一浩, 古賀 陽子, 佐藤 貴子, 友松 伸允, 成田 真人, 吉岡 徳枝, 小林 正治

    日本顎変形症学会雑誌   29 ( 1 )   11 - 22   2019.4

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    顎変形症治療コンセンサスミーティングの事前に行ったアンケート調査の概要を報告した。参加予定の36施設36人に対してweb入力方式により画面上にてアンケートを実施した。口腔外科医単独で治療計画を立案している施設はなく、19.4%の施設は矯正歯科医が単独で治療計画を立案しており、80.6%の施設は両者が共同で治療を立案していた。38.9%の施設は口腔外科医単独でスプリントを作製しており、44.4%の施設は矯正歯科医が単独で作製していた。両者が共同で作製している施設は16.7%と少なかった。75.0%の施設は半調節性咬合器を用いてスプリントを作製していたが、25.0%の施設は半調節性咬合器を使用していなかった。また、50%の施設では3Dプランニングを行っておらず、69.4%の施設は3Dプリンターを所有していなかった。30.6%の施設は原則全例に3Dモデルを作製しており、52.8%の施設は必要な症例(非対称症例など)のみに作製していた。

    File: コンセンサスミーティング.pdf

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  • 最先端technologyの口腔外科への応用 口腔顎顔面領域におけるシミュレーションとcomputer assisted surgery(CAS) 現状と将来展望

    岩井 俊憲

    日本口腔外科学会雑誌   65 ( 4 )   242 - 248   2019.4

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    File: CAS.pdf

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  • 歯肉出血を契機に診断された全身性エリテマトーデス(SLE)の1例

    南山 周平, 小澤 知倫, 岩井 俊憲, 杉山 聡美, 大澤 昂平, 林 雄一郎, 北島 大朗, 大澤 孝行, 藤内 祝

    日本口腔診断学会雑誌   32 ( 1 )   26 - 29   2019.2

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    症例は50歳代女性で、上顎歯肉の腫脹と出血を認めた。歯周炎の悪化を疑い、アモキシシリンが投与されるも改善せず、下肢の点状出血斑も出現したため、精査目的に当科を紹介受診した。当院血液腫瘍内科に診察を依頼したところ、特発性血小板減少性紫斑病疑いの診断のもと同科に緊急入院となった。入院後、プレドニゾロン(PSL)の経口投与を開始し、出血コントロールのために血小板輸血を10単位行った。入院2日目にも血小板輸血を5単位行ったが、血小板数はさらに低下を認め、追加検査で血小板数の低下以外に尿蛋白陽性、抗核抗体陽性、抗DNA抗体陽性がみられた。全身性エリテマトーデス(SLE)の分類基準を満たしたことからSLEに伴う血小板減少と診断された。血液腫瘍内科からリウマチ科に転科となり、PSLを増量後より血小板数は上昇を認め、入院58日目に退院となった。入院中、口腔内からの持続的な出血は認めず、下肢の点状出血斑も改善傾向であった。

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  • 内視鏡下に摘出した耳下腺腺体内唾石の1例

    吉井 悠, 岩井 俊憲, 杉山 聡美, 林 雄一郎, 大澤 孝行, 藤内 祝

    日本口腔外科学会雑誌   64 ( 12 )   715 - 719   2018.12

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    症例は56歳男性で、右側耳下腺部の腫脹を認め、CTで耳下腺唾石症と診断した。CTでは、右側耳下腺腺体内に3.6×2.5×1.7mm大の唾石を認めた。唾液腺内視鏡で診断的内視鏡検査を行い、耳下腺腺体内の導管の奥に唾石を認めた。唾石の破砕が必要で手術時間が長くなるため、全身麻酔下に内視鏡下唾石摘出術を施行した。手術翌日に退院した。その後の唾液の流出は良好で、術後1年9ヵ月以上経過した現在、耳下腺の腫脹や唾石の再発は認めていない。

    File: 耳下腺唾石.pdf

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  • 顔面非対称に対するナビゲーション手術と二次的顎矯正手術を行った下顎線維性異形成症の1例

    本田 康二, 岩井 俊憲, 藤田 紘一, 渋谷 直樹, 高須 曜, 大村 進, 小野 卓史, 藤内 祝

    日本顎変形症学会雑誌   28 ( 4 )   276 - 285   2018.12

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    線維性異形成症(FD)が顎骨に発生し骨の膨隆が著しい場合には、通常の顎矯正手術だけでは良好な顔貌形態が得られないことが多く、骨の削除術が必要となる。しかし、口腔内アプローチによる骨削除術は手術難易度が高く、十分な骨削除が行えないことも多い。今回、下顎FDにより顔面非対称と片側性鋏状咬合を呈した18歳男性例に対して、口内法によるナビゲーションガイド下骨削除術後に片側下顎臼歯部歯槽骨切り術と2分割Le Fort I型骨切り術(臼歯部での歯槽骨切り)行い、良好な結果が得られたので報告した。

    File: FD Navigation.pdf

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  • 唾液腺内視鏡下に摘出した顎下腺腺体内唾石の1例

    大澤 昂平, 岩井 俊憲, 佐久間 要, 杉山 聡美, 南山 周平, 北島 大朗, 林 雄一郎, 小栗 千里, 廣田 誠, 藤内 祝

    日本口腔診断学会雑誌   31 ( 3 )   225 - 228   2018.10

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    症例は50歳代男性で、右側顎下部の腫脹が食事時に生じたため、近耳鼻咽喉科を受診した。右側顎下腺唾石症と診断され、顎下腺摘出術が必要と説明されたため、唾液腺内視鏡での低侵襲な治療を希望して当科受診となった。唾石は顎下腺腺体上部に存在していたため、内視鏡下での唾石摘出が困難であった場合には、内視鏡をガイドにした口内法で唾石の摘出を行い、それが困難であった場合には顎下腺摘出術が必要になることを患者に説明し、同意を得たうえで全身麻酔での手術を計画した。細い唾液腺内視鏡は腺体内まで挿入可能であり、主導管から2分岐目に唾石を確認できた。唾液腺内視鏡のワーキングチャンネルからバスケット鉗子を挿入し唾石を把持した。唾石が類円形であったこともあり、開口部を切開せずに摘出可能であった。術後2年3ヵ月経過するも顎下腺の腫脹や唾仙痛は認めず、経過良好である。

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  • 口底癌の耳下腺リンパ節転移を疑わせたWarthin腫瘍の1例

    北島 大朗, 岩井 俊憲, 杉山 聡美, 林 雄一郎, 南山 周平, 大橋 伸英, 小栗 千里, 光藤 健司, 大澤 孝行, 藤内 祝

    日本口腔診断学会雑誌   31 ( 3 )   211 - 215   2018.10

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    症例は70歳代男性で、右側口底部の腫瘤を自覚したが放置していた。その後に腫瘤の増大を認めたため近医歯科を受診した。口底腫瘍と診断され、某総合病院歯科口腔外科を紹介され生検が行われた。扁平上皮癌と診断されたため、加療目的に当科を紹介受診となった。画像所見より正中よりやや右側の口底癌の左側耳下腺リンパ節への転移が疑われたが、腫瘍がT1であり、健側の表在リンパ節であることより、リンパ節内に生じたWarthin腫瘍の可能性も考えられた。そのため、センチネルリンパ節生検を行った。病理組織学的所見では、耳下腺リンパ節は円柱状細胞と立方状細胞の二層性配列を示す上皮が管状、嚢胞状に増生し、間質には濾胞形成を伴うリンパ球浸潤を認め、Warthin腫瘍と診断した。センチネルリンパ節に転移を認めなかったため、経過観察を行い、術後11ヵ月経過するが無病生存中である。

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  • 鼻部に及ぶ進行上顎歯肉癌に対し4経路を用いた逆行性超選択的動注化学放射線療法により原発切除を回避できた1例

    小栗 千里, 光藤 健司, 大橋 伸英, 飯田 昌樹, 岩井 俊憲, 小泉 敏之, 廣田 誠, 來生 知, 海津 久, 幡多 政治, 藤内 祝

    横浜医学   69 ( 4 )   543 - 548   2018.10

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    正中の進行上顎歯肉癌で鼻部に至る場合の拡大手術は顔面皮膚欠損及び口腔機能の障害を伴い、quality of lifeの低下を引き起こす。今回われわれは上唇から鼻部に及ぶ局所進行正中上顎歯肉癌に対し4経路を用いた超選択的動注化学放射線治療を施行した。患者36歳、男性。上顎歯肉癌(T4aN1M0)。患者は手術拒否であったため、4経路を使用した逆行性超選択的動注化学放射線治療(照射total 70Gy、docetaxelをtotal 70mg/m2、cisplatinをtotal 175mg/m2)を施行した。加えて、頸部リンパ節転移に対するハイパーサーミアを週1回、計6回行なった。治療後、腫瘍原発の治療効果判定はCRを得たため原発切除を回避した。治療後58ヵ月経過し現在まで再発・転移なく経過している。(著者抄録)

    File: 04_Oguri.pdf

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  • ナビゲーションシステムを用いて形成術を施行した上顎線維性異形成症の1例

    杉山 聡美, 岩井 俊憲, 大橋 伸英, 矢島 康治, 大澤 孝行, 藤内 祝

    日本口腔外科学会雑誌   64 ( 10 )   618 - 623   2018.10

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    症例は23歳男性で、18歳時に右側鼻腔の狭小化と右上顎の膨隆を指摘され、生検での結果Fibrous dysplasiaと診断された。経過観察されていたが、徐々に上顎が膨隆し顔貌の非対称が強くなったため手術が必要と判断された。手術は、右側上顎の膨隆した骨を顔面の対称性が得られるように削除するために、ナビゲーションシステムを用いた形成術を計画した。上顎右2近心に縦切開を行い、上顎右7まで歯肉縁切開を行った。その後、骨膜下を剥離し、膨隆した上顎骨を明示した。ナビゲーションガイド下にミラーリング像を指標にしながら、膨隆した骨にミラー像の深さまでグループを入れた後に、グループをつなげるようにラウンドバーで骨の削除を行った。術中、患者頭部に固定したリファレンスに助手が触れたことでナビゲーョンの誤差が生じたため、オクルーザルスプリントを両度装着し、再レジストレーションを行った。ナビゲーションの誤差が1mm以内になった後、手術を再開した。その後、プローブで骨削除断端部を触れることで、計画通りの骨削除が行えているかナビゲーションシステムのモニター上で確認しながら、十分な骨削除量が得られるまで手術を行った。術後経過は良好であり、術後9年経過するも左右対称な顔貌が得られている。

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  • 局所麻酔下に内視鏡下摘出術を施行した顎下腺腺体内唾石の1例

    南山 周平, 岩井 俊憲, 杉山 聡美, 林 雄一郎, 大橋 伸英, 北島 大朗, 小栗 千里, 廣田 誠, 大澤 孝行, 藤内 祝

    日本口腔診断学会雑誌   31 ( 2 )   156 - 159   2018.6

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    70歳代女。右側顎下部の腫脹を主訴とした。CTで右側顎下腺の腺体中央部に3.1×2.8×2.6mmの唾石を認め、右側顎下腺腺体内唾石症と診断した。唾石は腺体中央部に存在していたが、大きさが約3mm程度であり、CT値が低いため粉砕が容易にできる可能性が高く、更に顎下腺移行部から唾石まで唾液の貯留が描出されていたことから、内視鏡手術が可能と判断した。受診当日に外来局所麻酔下に内視鏡下唾石摘出術を施行し、手術時間は35分と短く、術後経過は良好であった。術後1年4ヵ月の現在、再発は認めていない。

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  • ナビゲーション手術を施行した上顎の骨形成線維腫の1例

    杉山 聡美, 岩井 俊憲, 大澤 昂平, 林 雄一郎, 大橋 伸英, 南山 周平, 北島 大朗, 廣田 誠, 大澤 孝行, 藤内 祝

    日本口腔診断学会雑誌   31 ( 2 )   166 - 170   2018.6

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    15歳男。顔面非対称を主訴とした。7歳時より左耳翼基部の膨隆を自覚し、2年前に生検にて線維性異形成症(FD)と診断されていた。口腔外所見では左鼻翼から鼻根部や頬部にかけて膨隆し、斜鼻を認めた。口腔内所見では左側上顎歯肉唇移行部から口唇粘膜にかけて骨の膨隆を認めた。CTでは左上顎洞を後方に圧排するように境界明瞭な充実性病変を認め、左鼻腔は閉塞していた。3D-CTでは左鼻骨、左上顎骨、左頬骨の膨隆を認めた。FDとしては典型的な画像所見ではなかったため生検を行ったところ、病理組織学的に骨形成線維腫(OF)またはFDの所見であった。画像所見と併せて考えOFと診断し、ナビゲーション手術を計画した。腫瘍を摘出した後、術前に行った健側をミラーリングした画像まで骨の削除を行い、手術を終了した。術直後の3D-CTでは左側上顎の膨隆していた骨が計画通りに削除されていることが確認できた。病理診断はOFであった。術後2年6ヵ月の現在、知覚異常はなく、左右対称の顔貌と左鼻腔の開存が得られている。

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  • 顎下腺管内の肉芽組織を内視鏡下で摘出した1例

    大澤 昂平, 岩井 俊憲, 杉山 聡美, 林 雄一郎, 大橋 伸英, 南山 周平, 北島 大朗, 小栗 千里, 大澤 孝行, 藤内 祝

    日本口腔診断学会雑誌   31 ( 1 )   21 - 24   2018.2

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    症例は10歳男児で、食事時の右側顎下部の腫脹を認めた。CTにて右側顎下腺唾石症と診断した。右側口底後方粘膜に自壊部を認めたが、排膿は認めなかった。嘔吐反射が強く口底部の触診は困難であった。右側舌下小丘部からの唾液の流出は認めなかった。CTでは右側顎下腺移行部に56×56×42mmの硬組織像を認めた。臨床所見から、急性化膿性顎下腺炎により口底粘膜から排膿ととともに唾石が排出された後に、自壊部から顎下腺移行部に生じた肉芽組織が導管を閉塞させていると考え、閉塞性顎下腺炎と診断した。抗菌薬による消炎を行い、唾液腺内視鏡による閉塞物の摘出術を計画した。全身麻酔下で内視鏡手術を行った。外来経過観察時の唾液の流出は良好となり、以後、顎下腺の腫脹は生じていない。

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  • 著しい開口障害を伴う陳旧性下顎骨骨折に対する骨延長法において咬合斜面板とII級ゴムを用いた1例

    青木 紀昭, 井上 愛里彩, 小杉 泰史, 小山 千佳, 飯田 昌樹, 遠藤 大雅, 山下 陽介, 馬場 隼一, 岩井 俊憲, 藤内 祝

    日本顎変形症学会雑誌   27 ( 4 )   213 - 220   2017.12

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    症例は49歳男性で、48歳時に自宅3階の窓から転落し、救急搬送された。全身多発骨折(頸椎・左側下顎頸部・骨体部粉砕骨折、左側肋骨・右側大腿骨・膝蓋骨骨折)に対し救急処置後、口腔外科で受傷1ヵ月後に咬合改善のため、下顎骨観血的整復固定術を受けたが術後より下顎退位を認めた。49歳時にチタンプレート除去術を受け、転落事故後の上顎前歯の突出感、咀嚼障害の改善を希望し、紹介受診した。体格は中等度で、栄養状態は良好であった。顔面は左右対称であるが、両側オトガイ神経領域に瘢痕拘縮を認めた。両側オトガイ神経領域に知覚鈍麻を認め、下顎の前方運動障害と著しい開口障害を認めた。側方運動量は左側3mm、右側1mm、最大開口量は13mmであったが、顎関節強直は認めず、右側下顎頭、左側関節突起の運動を触知できた。全顎的に3〜4mmの歯周ポケットと歯石沈着を認め、下顎右側第一大臼歯、下顎左側犬歯、下顎左側第二小臼歯、下顎左側第一大臼歯は欠如、上顎左側第一小臼歯、上顎左側第三大臼歯は残根を呈していた。前歯部の被蓋関係はオーバージェット+9mm、オーバーバイト+7mmであった。上顎左側第一大臼歯は過萠出し下顎歯槽堤と咬合し、上顎口蓋歯肉に下顎前歯部の圧痕を認めた。CTでは下顎骨体部の粉砕骨折と左側下顎頸部骨折による関節突起の転位脱臼を認めた。治療方針として歯周病治療、上顎左側第三大臼歯抜歯、下顎骨骨延長法と補綴治療による咬合と顔貌の改善を行うこととした。瘢痕拘縮が著しく従来の下顎骨骨延長単独での治療は下顎の前方への延長が困難となる可能性があり、咬合斜面板とII級ゴム併用とした。術後、下顎の後退感は改善し、水平的・垂直的にも適切な前歯・臼歯咬合関係が得られた。術後1年3ヵ月経過したが創部治療良好で、咬合関係も良好である。

    DOI: 10.5927/jjjd.27.213

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  • 抗血栓療法中の患者に対して臼後スペースを利用した経口挿管下で口腔外科手術を行った1例

    佐久間 要, 岩井 俊憲, 上田 潤, 田中 彰

    有病者歯科医療   26 ( 5 )   373 - 377   2017.11

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    全身麻酔下の口腔外科手術はたいてい経鼻挿管で行われるが、抗血栓療法中の患者では鼻出血のリスクを回避するため経口挿管が選択されることになる。しかし、両側の口腔外科手術で経口挿管が行われるとき、術中に気管チューブを対側へ固定し直す必要がある。今回、われわれは気管チューブを再固定する必要がない低侵襲で簡単な方法として、抗血栓療法中の患者に対する臼後スペースを利用した挿管法について報告する。右側の顎下腺唾石と両側埋伏智歯、左側上顎智歯を有する22歳の女性は、抗血栓療法中のため臼後スペースを利用した挿管後に両側の口腔外科手術を受けた。術中の気道のトラブルや手術の障害は生じなかった。通常の経口挿管での口腔外科手術が困難な時、臼後部を通した経口気管チューブの固定法は経鼻挿管、オトガイ下挿管や気管切開の代替となるかもしれない。(著者抄録)

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  • 下顎骨を含む多臓器型Langerhans'-cell histiocytosisの1例

    中島 英行, 岩井 俊憲, 南山 周平, 渡貫 圭, 光藤 健司, 藤内 祝

    日本口腔外科学会雑誌   63 ( 11 )   570 - 575   2017.11

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    症例は37歳男性で、健康診断で塵肺が疑われた。重度歯周炎で右下6番を抜歯したが、抜菌窩治癒不全を認めた。同部の急速な歯槽骨吸収を認めた。右下6番の抜歯窩は陥凹しているが、骨露出はなく肉芽形成を認めた。パノラマX線写真では、右下6番抜歯窩を中心に下顎骨の辺縁不正な骨吸収像を認め、骨吸収像は下顎管に近接していた。CT所見では右下7番から右下6番に至る下顎骨の吸収を認め、頬側および舌側の皮質骨は不整な吸収像を認めた。深部の骨吸収は粗造に下顎管周囲に及んでいた。両肺の上中肺野優位に粒状構造、気管支の軽微な拡張や壁肥厚がみられた。局所麻酔下に右下6番抜歯窩より生検を施行し、Langerhans'-cell histiocytosis(LCH)と病理組織学的診断した。肺病変は気管支鏡下に生検を行い、LCHと診断した。全身麻酔下に右下8-5番の抜歯および腫瘍摘出術・掻爬術を施行した。術後約2年が経過し、右側大腿部の疼痛を自覚した。右側大腿骨部腫瘍掻爬術および腸骨移植術を行い、術後の病理診断はLCHであった。その後2年が経過しているが、口腔内および他部位での新病変の出現は認めていない。

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  • 皮膚自潰部から自然排出された耳下腺導管内唾石の1例

    杉山 聡美, 岩井 俊憲, 吉井 悠, 林 雄一郎, 上田 潤, 佐久間 要, 大橋 伸英, 小栗 千里, 廣田 誠, 藤内 祝

    日本口腔診断学会雑誌   30 ( 2 )   193 - 196   2017.6

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    60代男性。左側耳下腺導管内唾石症と診断され、内視鏡下唾石摘出術を行う予定であった。しかし、初診から3週間後、左側頬部の腫脹や硬結の増大を認め、その中央部は自潰していた。自潰部からは排膿を認めたため、抗菌薬による消炎処置を継続したところ、1週間後に唾石と思われる石灰化物2個が自潰部から自然排出した。エコーでも唾石の残存がなく、1ヵ月経過後には左側頬部の腫脹は消失し、自潰部は完全に閉鎖していた。本例は、唾石に感染を併発したことで膿瘍が形成され、導管外の膿瘍腔へ唾石が逸脱し、皮膚瘻孔からの排膿とともに唾石が自然排出されたと考えられた。

    DOI: 10.15214/jsodom.30.193

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  • 小児に生じた両側顎下腺唾石症の1例

    吉井 悠, 岩井 俊憲, 杉山 聡美, 林 雄一郎, 大橋 伸英, 馬場 隼一, 小栗 千里, 廣田 誠, 太田 信介, 藤内 祝

    日本口腔診断学会雑誌   30 ( 2 )   223 - 225   2017.6

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    7歳男児。左顎下部の腫脹を主訴に前医を受診し、両側顎下腺導管移行部唾石と診断された。唾石のサイズが小さいことから、自然排出を期待して経過観察された。10ヵ月後に前医を再診し、唾石の位置と大きさに変化がみられなかったため顎下腺摘出術を提案されたが、本人と家族は内視鏡による低侵襲な治療を希望し、当科に紹介された。左側の唾石は1.7×1.7×1.1mm大で、初診2ヵ月後に開口部付近まで移動し、外来局所麻酔下に容易に摘出することができた。右側は3.0×1.6×1.5mm大で、初診8ヵ月後に開口部付近まで移動し、外来で容易に摘出することができた。

    DOI: 10.15214/jsodom.30.223

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  • 口腔癌に対する逆行性動注化学放射線療法のカテーテル関連血流感染症に関する検討

    柴崎 麻衣子, 小泉 敏之, 岩井 俊憲, 中島 英行, 小栗 千里, 來生 知, 廣田 誠, 光藤 健司, 根岸 明秀, 藤内 祝

    日本口腔外科学会雑誌   63 ( 4 )   178 - 184   2017.4

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    DOI: 10.5794/jjoms.63.178

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  • 内視鏡下に摘出した耳下腺導管内唾石の1例

    小杉 泰史, 岩井 俊憲, 太田 信介, 小栗 千里, 光藤 健司, 藤内 祝

    日本口腔外科学会雑誌   63 ( 3 )   153 - 157   2017.3

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    症例は64歳女性で、食事時に左側頬部の腫脹を認めた。CTにて左側耳下腺唾石と診断され、その後も左側頬部の腫脹を繰り返した。CTでは左側咬筋前縁より後方外側の耳下腺導管内に3.4×2.5×2.0mm大の類円形の唾石を認め、開口部と腺体のほぼ中央に位置した。左側耳下腺導管内唾石と診断し、全身麻酔下にて内視鏡下唾石摘出術を施行した。手術翌日に退院し、その後の唾液の流出は良好で耳下腺の腫脹や唾石の再発は認めていない。

    DOI: 10.5794/jjoms.63.153

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  • 局所麻酔下に内視鏡下摘出術を施行した耳下腺腺体内唾石の1例

    杉山 聡美, 岩井 俊憲, 吉井 悠, 林 雄一郎, 上田 潤, 佐久間 要, 大橋 伸英, 小栗 千里, 廣田 誠, 藤内 祝

    日本口腔診断学会雑誌   30 ( 1 )   52 - 55   2017.2

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    40歳代女性。左側頬部の腫脹と唾仙痛を主訴に近医耳鼻咽喉科を受診し、CTにて左側耳下腺腺体内唾石と診断され、手術目的に紹介となった。受診時、CTで唾石は1.7×1.4×1.0mmと比較的小さかったため、局所麻酔下に内視鏡下唾石摘出術を行った。術後経過は良好で、現在まで耳下腺の腫脹や唾石の再発は認められていない。

    DOI: 10.15214/jsodom.30.52

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  • 頬骨部に発生した顆粒細胞腫の1例

    岡本 喜之, 山本 学, 宮本 政幸, 矢島 康治, 中島 英行, 馬場 隼一, 大橋 伸英, 岩井 俊憲, 藤内 祝, 石川 好美

    日本口腔診断学会雑誌   30 ( 1 )   60 - 64   2017.2

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    57歳女性。右頬骨部の腫脹を主訴に精査目的で近医より紹介となった。初診時、右頬骨部の皮下に20mm大の腫瘤を認め、単純MRI所見より右頬骨部良性腫瘍を考え、経過観察とした。しかし、初診から11ヵ月目に腫瘍の増大を認めた。MRIでは腫瘍は初診時の最大径18mmから26mmへ増大、全身麻酔下に右頬部腫瘍摘出術を施行したところ、術中迅速病理診断で顆粒細胞腫が最も考えられた。そこで、剥離困難であった大頬骨筋側の筋組織を一部付けて腫瘍を切除した。病理組織学的に顆粒細胞腫であり、術後は頬の動きの違和感、頬骨隆起部に軽度の知覚鈍麻を認めたが、メコバラミンの内服にて術後約3ヵ月目には軽快した。術後2年2ヵ月経過現在、再発はみられない。

    DOI: 10.15214/jsodom.30.60

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  • 上下顎同時骨延長術を施行した著しい垂直的上顎劣成長を伴う下顎前突症の1例

    本田 康二, 大村 進, 藤田 紘一, 渋谷 直樹, 米満 郁男, 島崎 一夫, 村田 彰吾, 高須 曜, 山下 陽介, 岩井 俊憲, 小野 卓史, 藤内 祝

    日本顎変形症学会雑誌   26 ( 4 )   275 - 283   2016.12

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    25歳男。笑った時に上顎前歯がみえないことから顔貌の改善を希望し、術前の矯正治療終了後に当院紹介受診された。側貎は上顎が後退し中顔面の顔面高が小さく、また上顎が垂直的に劣成長のため前下顔面高の比率が低値を示した。口腔内所見、側面頭部X線規格写真分析所見より、上顎骨の垂直的劣成長を伴う骨格性下顎前突症と診断した。マルチブラケット装着による術前矯正治療の後、歯槽骨延長器を用いた上下顎骨同時骨延長を行った。その結果、鼻下点からオトガイ下点までの前顔面高の比率が良好となり、安定した咬合も得られた。

    DOI: 10.5927/jjjd.26.275

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  • 内視鏡下に摘出した小児顎下腺唾石の1例

    上田 潤, 岩井 俊憲, 小澤 知倫, 小栗 千里, 光藤 健司, 藤内 祝

    日本口腔外科学会雑誌   62 ( 11 )   575 - 578   2016.11

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    11歳女児。他院にて左側顎下腺唾石と診断され顎下腺摘出術の説明を受けたが、内視鏡による低侵襲治療を希望し当科紹介受診となった。初診時、顎下部に腫脹を認めたため抗菌薬の投与にて消炎をはかり、全身麻酔下での唾液腺内視鏡を用いた唾石摘出術を予定した。左側導管開口部に24Gの血管留置針の外筒をつけた細いブジーを挿入し、その後外筒を深く挿入することで開口部の拡大を図った。開口部から導管内に直径1.6mmの唾液腺内視鏡を挿入し、イリゲーションチャンネルから生理食塩水を注入することで導管を拡大して視野を確保した。内視鏡を導管深部に挿入すると移行部に唾石を確認することができ、バスケット鉗子を挿入して唾石を把持・牽引し、拡大した開口部から摘出した。手術時間は8分で、出血は認めなかった。手術翌日に退院となり、再発なく経過良好である。

    DOI: 10.5794/jjoms.62.575

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  • 口腔内に初発症状を呈した節外性悪性リンパ腫の検討

    杉山 聡美, 岩井 俊憲, 小栗 千里, 中島 英行, 小泉 敏之, 太田 信介, 廣田 誠, 來生 知, 光藤 健司, 藤内 祝

    頭頸部癌   42 ( 3 )   339 - 344   2016.10

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    口腔内に初発症状を呈する節外性悪性リンパ腫(ML)は非常にまれである。われわれは2005年1月から2015年12月までの間に当科を受診した口腔悪性腫瘍患者1,081例のうち口腔内に初発症状を呈した節外性ML10例について臨床的特徴を検討した。男性は7例、女性は3例であり、年齢は8〜82歳(平均年齢:64.4歳)であった。8例が歯肉に生じており、その他の部位としては口底と頬粘膜に生じていた。病理診断ではびまん性大細胞型B細胞リンパ腫が7例を占めていた。Ann Arbor分類ではステージI、II、III、IVはそれぞれ、3、1、2、4例であった。さらに、本邦で報告された口腔内に初発症状を呈する節外性ML115例を検討した。口腔病変を診断する際には、MLが口腔内に発生しうることを念頭に置くべきである。(著者抄録)

    DOI: 10.5981/jjhnc.42.339

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  • 陳旧性下顎頸部骨折に外科的矯正手術を応用し咬合改善を行った1症例

    青木 紀昭, 遠藤 大雅, 馬場 隼一, 山下 陽介, 岩井 俊憲, 藤内 祝

    日本口腔診断学会雑誌   29 ( 3 )   150 - 154   2016.10

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    症例は69歳女性で、交通事故で救急搬送された。頭部損傷、クモ膜下出血、頭部出血、鎖骨・肋骨・骨盤骨折と診断され、クモ膜下出血の治療や歩行訓練や日常生活が自立できるような運動療法を中心としたリハビリテーションを長期間行った。噛み合わせが悪いと感じていたが日常生活に支障がなく放置した。陳旧性下顎骨骨折の疑いによる咬合不全と診断された。パノラマX線写真では左側下顎頭の変形と下顎枝高径の短縮を認めた。CT画像の水平断像と前額断像では左側下顎頭が内側に転位し変形治癒を認めた。三次元CT画像では左側下顎頭の頸部にて骨折線を認め、内側に転位脱臼し変形治癒を認めた。陳旧性下顎骨骨折と診断し、全身麻酔下にて両側の下顎枝垂直骨切り術による観血的整復法を施行した。骨接合は施行せず術翌日から約14日間の顎間ゴム牽引を施行した。退院後も咬合の安定と偏位防止のためアーチバーを3ヵ月間装着させてエラスティックの使用を継続しながら経過観察した。5年経過するも、現在まで異常はなく、咬合状態も安定している。

    DOI: 10.15214/jsodom.29.150

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  • 口腔癌N0症例の頸部マネージメント 口腔癌N0症例に対するインドシアニングリーン(ICG)蛍光法を用いたセンチネルリンパ節生検

    岩井 俊憲, 小栗 千里, 吉井 悠, 大橋 伸英, 林 雄一郎, 飯田 昌樹, 中島 英行, 小泉 敏之, 廣田 誠, 來生 知, 光藤 健司, 藤内 祝

    日本口腔腫瘍学会誌   28 ( 3 )   65 - 70   2016.9

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    口腔癌N0症例のうち20〜30%の頻度で後発頸部リンパ節転移が生じるが、経過観察するか予防的頸部郭清術を行うかといった頸部に対する治療方針に統一した見解は得られていない。様々な画像診断が行われるにも関わらず頸部リンパ節転移を正確に診断することは困難であるため、色素法、ラジオアイソトープ(RI)法、あるいはその両者を用いたセンチネルリンパ節生検(SLNB)が近年行われるようになってきた。しかし、RI法を用いたSLNBはどの施設でも行えるわけではない。そのため、RIを用いない方法として、口腔癌N0症例に対するインドシアニングリーン(ICG)蛍光法を用いたSLNBについて報告する。(著者抄録)

    File: PDF.pdf

    DOI: 10.5843/jsot.28.65

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  • 横浜市立大学附属市民総合医療センター歯科・口腔外科・矯正歯科における過去16年間の顎変形症治療に関する実態調査

    本田 康二, 大村 進, 藤田 紘一, 渋谷 直樹, 米満 郁男, 島崎 一夫, 村田 彰吾, 高須 曜, 山下 陽介, 岩井 俊憲, 小野 卓史, 藤内 祝

    日本顎変形症学会雑誌   26 ( 3 )   195 - 201   2016.8

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    2001年1月〜2015年12月迄の16年間に受診し、外科的矯正治療適応と診断し、顎矯正手術施行した患者798名(男性247名、女性551名)を対象に、各年別症例数、性別症例数・男女比、年齢別症例数、臨床診断別症例数、術式別症例数を調査し、検討した。開設年の顎矯正手術施行数は年間7例であったが、最近5年間の年間平均症例数は72.8例であった。男女比は1:2.2と男性に比べ女性の比率が高かった。全患者の手術時平均年齢は26.6歳であった。年代別の割合では16〜25歳が全体の56.8%と最多で、26〜35歳28.2%、36〜45歳12.0%、46歳以上3.0%であった。経年的変化として大きな傾向の変化はなく、平均年齢25〜30歳を推移していた。臨床診断別では下顎前突が38.7%と最多で、非対称を伴う下顎前突が16.8%、非対称症例12.0%、上顎前突症および下顎後退症10.4%、開咬を伴う下顎前突8.5%、非対称と開咬を伴う下顎前突3.6%、開咬を伴う上顎前突2.4%、非対称を伴う上顎前突2.0%、その他5.6%であった。5年毎の経年的変化は非対称を伴う下顎前突症、開咬を伴う下顎前突に増加傾向がみられ、上顎前突、下顎後退症が減少した。手術方法はLeFort型骨切り術と下顎枝矢状分割法(SSRO)による上下顎移動術が59.3%と最多でSSRO単独が23.7%となっていた。

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  • 進行口腔癌に対する逆行性超選択的動注化学放射線療法 頸部リンパ節転移に対する治療効果

    光藤 健司, 小泉 敏之, 飯田 昌樹, 岩井 俊憲, 中島 英行, 小栗 千里, 廣田 誠, 來生 知, 藤内 祝

    日本口腔腫瘍学会誌   28 ( 2 )   27 - 32   2016.6

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    われわれは頸部リンパ節転移を有する進行口腔癌に対し逆行性超選択的動注化学放射線療法(以下動注CCRT)を施行し、転移リンパ節に対する治療効果につき検討したので報告する。対象は2007年2月から2010年11月までに進行口腔癌(T2-4bN1、2M0)に対し根治的動注CCRTを施行し、原発巣がCRのため原発は手術回避、頸部郭清術のみを行った20症例である。N分類はN1:5例、N2b:10例、N2c:5例であった。治療は浅側頭動脈、後頭動脈より逆行性に腫瘍の栄養動脈に動注カテーテルを留置し、動注CCRTを5-6週間(docetaxel:total 50-60mg/m2、cisplatin:total 125-150mg/m2、RT:total 50-60Gy)施行した。治療終了後5から8週に頸部郭清術を行い、摘出したリンパ節の病理組織学的検索を行ったところ、転移リンパ節がpCRであったのは20例中13例(65%)であった。その後経過観察中に頸部再発を認めたのは2例(10%)であった。20例中13例は生存、7例が死亡(6例が遠隔転移、1例が頸部の非制御)した。以上より動注CCRTは、口腔癌の頸部転移リンパ節にも有用であることが示唆された。(著者抄録)

    File: _pdf.pdf

    DOI: 10.5843/jsot.28.27

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  • 上顎前歯部歯槽骨欠損に歯科矯正治療と骨移植に対する垂直的仮骨延長を併用してインプラント治療を施行した1例

    君塚 幸子, 大村 進, 岡本 喜之, 青木 伸二郎, 岩井 俊憲, 廣田 誠, 濱田 良樹, 藤内 祝

    Japanese Journal of Maxillo Facial Implants   13 ( 4 )   261 - 267   2014.12

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    22歳女。交通事故による顎顔面外傷後の右側上顎前歯欠損のインプラント治療を希望した。歯槽骨とともに右側上顎側切歯〜第一小臼歯が欠損し、右側上顎中切歯の歯根は露出していた。さらに下顎前歯は挺出して歯軸が近心や舌側に傾斜していた。インプラント埋入の前処置として上顎洞の骨欠損部にチタンメッシュを置き、その上に左前腸骨稜より採取した海綿骨細片を移植したが、十分な骨造成を行うことができず、生着した移植骨に対して全身麻酔下に垂直的仮骨延長を行った。さらに歯科矯正治療を行って歯列や咬合関係を改善し、最終的に3本のインプラントを埋入した。インプラント治療終了後は顎関節症状が消失して良好な咬合関係と審美性の改善が得られ、6年経過現在可撤式保定装置を使用して咬合状態は良好である。

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  • 術後感染に対する抗菌薬により生じた薬剤熱の1例

    南山 周平, 岩井 俊憲, 馬場 隼一, 青木 紀昭, 藤内 祝

    日本口腔診断学会雑誌   27 ( 2 )   177 - 181   2014.6

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    40歳男。左側下顎歯肉に腫脹が出現し徐々に増大した。パノラマX線写真では左側下顎第一大臼歯から下顎枝にかけて多房性のX線透過性病変を認めた。生検にて歯原性粘液線維腫と診断した。全身麻酔下にて腫瘍を摘出後、可及的に下顎骨の削合を行い開窓した。周術期の感染予防で抗菌薬を使用したが、有害事象は認めなかった。その後、CTと生検で再発を認め、下顎骨区域切除術、腸骨海綿骨移植およびチタンメッシュとプレートによる再建術を施行した。経過が良好で、術後14日目に軽快退院した。退院後26日目、左側顎下部は腫脹し、術後感染と診断した。全身麻酔下で感染移植骨およびプレート除去術を施行した。感染制御は良好であったが、術後8日目より発熱を認めた。発熱の明らかな原因を特定できなかったため薬剤熱を疑い、投与中であったVCMおよびAMPCを中止した。翌々日には解熱した。退院後も発熱は認めず、抗菌薬による薬剤熱と診断した。

    DOI: 10.15214/jsodom.27.177

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  • 口腔癌患者の上部消化管領域における同時性重複癌のスクリーニング 上部消化管内視鏡検査と18F-FDG-PET/CTの比較

    岩井 俊憲, 柴崎 麻衣子, 北島 大朗, 矢島 康治, 中島 英行, 小栗 千里, 廣田 誠, 光藤 健司, 藤内 祝

    日本口腔腫瘍学会誌   26 ( 2 )   31 - 36   2014.6

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    われわれは口腔癌患者の上部消化管領域における同時性重複癌のスクリーニングとしての上部消化管内視鏡検査(GIF)とFDG-PET/CTについて比較したので報告する。2006年9月から2009年8月までの3年間に口腔癌患者133例が治療前にGIFとFDG-PET/CTを受けた。GIFで5人の患者(3.8%)に食道や胃の同時性重複癌が発見され、それらは全例早期癌であった。しかし、FDG-PET/CTでは1人のみしか同時性重複癌(食道癌)が発見できず、その感度と特異度はそれぞれ20%と100%であった。本研究は口腔癌患者の上部消化管領域における治療前スクリーニングとしてのGIFの有用性と必要性を示した。(著者抄録)

    File: PET GF.pdf

    DOI: 10.5843/jsot.26.31

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  • Chemoradiotherapy using retrograde superselective intra-arterial infusion for advanced oral cancer Therapeutic effect for T3 and T4 squamous cell carcinoma of the upper gingiva

    KOIZUMI TOSHIYUKI, MITSUDO KENJI, OGURI SENRI, IWAI TOSHINORI, MITSUNAGA SACHIYO, IISAKA TOMOHIRO, KIOI MITOMU, HIROTA MAKOTO, CHIKAZU DAICHI, TONAI IWAI

    39 ( 4 )   443 - 448   2013.12

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  • ビスフォスフォネートによる上顎骨壊死とメトトレキサート関連リンパ増殖性疾患の併発を疑った1例

    山下 陽介, 岩井 俊憲, 宮崎 千佳, 大村 進, 青木 紀昭, 藤内 祝

    日本口腔外科学会雑誌   58 ( 6 )   371 - 375   2012.6

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    症例は66歳女性で、関節リウマチでメトトレキサート(MTX)、骨粗鬆症でアレンドロン酸ナトリウムを服用していた。歯科で右側上顎第一大臼歯の抜歯を受け、抜歯窩の治癒は悪く疼痛が持続した。CTで右側上顎大臼歯部を中心に腐骨形成を認め、上顎洞底と口蓋板は欠損し、口腔は鼻腔と交通していた。腐骨の病理検査で悪性病変は認めず、ビスフォスフォネート製剤による顎骨壊死と診断し、アレンドロン酸ナトリウムを中止して抗菌薬投与、局所洗浄を行った。しかし右側上顎第一小臼歯から中切歯まで脱落し、骨壊死は拡大して発熱が出現した。腫瘍性病変を疑い、再度の生検で中〜大型の異型リンパ球様細胞のび漫性増殖を認め、diffuse large B-cell lymphomaと診断された。MTX中止、プレドニゾロン減量としたところ、徐々に解熱傾向となり、3ヵ月後には口腔内の病変は消失した。12ヵ月後も病変の再発はなく、最終的にMTX関連リンパ増殖性疾患と診断された。

    File: MTX.pdf

    DOI: 10.5794/jjoms.58.371

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  • 顎顔面骨折患者における気管チューブの臼後部固定法の経験

    岩井 俊憲, 前川 二郎, 安村 和則, 矢島 康治, 柴崎 麻衣子, 馬場 隼一, 大屋 貴志, 大原 良仁, 藤内 祝

    日本口腔診断学会雑誌   25 ( 1 )   19 - 21   2012.2

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    顎間固定が可能となる気管チューブの臼後部固定法を用い、顎顔面骨折整復固定術を施行した4名(全男、17〜27歳)について報告した。内訳は鼻篩骨と顎骨の合併骨折や頭蓋底骨折を認めた顔面多発骨折患者3名、鼻腔狭窄と抗凝固療法中のため経鼻挿管が困難であった下顎骨折患者1名であった。まず気管チューブをテープで口角に固定し、ワイヤーを反対側の上顎第一或いは第二大臼歯に固定した後、口角から外した気管チューブを反対側に移動させて臼後部に通し、歯列の頬側にワイヤーで固定した。顎間固定中の臼後部における気管チューブの圧迫は存在したが、気道内圧の亢進やSpO2の低下を認めた症例はなかった。良好な術野が全例で得られ、手術操作に支障はなく、整復・固定は良好に行うことができた。

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  • 下顎顎堤欠損症に歯槽骨延長とインプラント治療を行った1例 角度調節可能なAlveolar Ridge Distraction Systemの使用経験

    君塚 幸子, 大村 進, 廣田 誠, 岩井 俊憲, 村田 彰吾, 小澤 知倫, 渡貫 圭, 藤内 祝

    Japanese Journal of Maxillo Facial Implants   10 ( 4 )   237 - 242   2011.12

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    43歳女。下顎骨正中部線維性骨異形成症に対し全身麻酔下に下顎骨辺縁切除を行い、腸骨海綿骨骨髄移植による下顎骨再建術を施行した。術後経過は再発なく良好で、術後4ヵ月で顎義歯を装着した。術後約1年、義歯による清掃性や咬合力の不足、違和感などの改善を目的にインプラント治療を希望して受診した。パノラマX線写真では、顎堤欠損を認めた。下顎骨辺縁切除後の前歯部歯槽部は垂直的な高さが不足し、機能的・審美的なインプラント治療には骨造成が必要と考えた。骨病変切除後16ヵ月に残存骨の垂直的骨延長を施行した。延長方向を唇側に設定するため、シムプレートを移動骨片と固定用プレートの間に挿入した。術後経過は良好で、計10mmの骨延長ができた。骨延長終了し7ヵ月の安定化期間をおいて延長器を除去し、その後3本のインプラントを埋入した。4年経過後もインプラントは臨床的に安定し、インプラント義歯により咀嚼機能も良好である。

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  • 癌化学療法における口内炎に対するG-CSF(グラン)含嗽製剤の有用性に関する検討 Preliminary study

    渡貫 圭, 光藤 健司, 光永 幸代, 君塚 幸子, 岩井 俊憲, 小栗 千里, 小泉 敏之, 廣田 誠, 大村 進, 藤内 祝

    日本口腔腫瘍学会誌   23 ( 4 )   139 - 145   2011.12

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    口内炎は癌化学療法による有害事象のひとつであるが、本邦では現在有効な予防法や治療法は確立されていない。欧米では癌化学療法による口内炎に対してG-CSF製剤による含嗽が応用されている。そこでわれわれはG-CSF含嗽剤を作製し、癌化学療法による口内炎に応用したところ、本治療にて口内炎治療に良好な結果が出たので報告する。対象は口腔癌を含む固形癌あるいは白血病と診断され化学療法中に口内炎が出現した6名で、口内炎がgrade 3あるいは4まで悪化した時点で、フィルグラスチム製剤による含嗽治療を1日4回1回75μgで5日間行い、口内炎改善度を評価した。口内炎は著しく良化し、疼痛や摂食も改善した。G-CSF含嗽剤は口内炎の治療に、ひいてはQOLの改善に非常に有用であった。(著者抄録)

    File: グラン.pdf

    DOI: 10.5843/jsot.23.139

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  • 両側浅側頭動脈よりの超選択的動注法を用いた連日同時放射線化学療法を施行した舌背部扁平上皮癌の1例

    大久保 牧子, 岩井 俊憲, 光藤 健司, 光永 幸代, 小栗 千里, 渡貫 圭, 廣田 誠, 松井 義郎, 藤内 祝

    日本口腔腫瘍学会誌   23 ( 4 )   147 - 153   2011.12

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    舌癌のほとんどは舌側縁や舌下面に生じることが多く、舌背部に生じることは極めてまれである。われわれは両側浅側頭動脈よりの超選択的動注法を用いた連日同時放射線化学療法を施行した舌背扁平上皮癌の1例について報告する。80歳の男性は左側舌背部の腫瘤を主訴に当科を受診した。腫瘤は有茎性で、その大きさは舌背の前方の硬結を含め49×30×12mmであった。生検後、病変は扁平上皮癌と診断された。頸部リンパ節転移は認めなかった。進行舌癌に対する再建術後の機能障害を避けるために、逆行性超選択的動注化学放射線療法を計画した。両側浅側頭動脈よりの超選択的動注法を用いた連日同時放射線量療法(ドセタキセル(10mg/m2/week、total 96mg/body)、シスプラチン(5mg/m2/day、total 240mg/body)、外照射(2Gy/日、計60Gy)を6週間施行した。現在治療後25ヵ月が経過するが、再発・転移なく経過良好である。(著者抄録)

    File: 舌背癌.pdf

    DOI: 10.5843/jsot.23.147

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  • 口腔癌の機能温存を目指した集学的治療 進行口腔癌に対する逆行性超選択的動注化学放射線療法

    光藤 健司, 岩井 俊憲, 光永 幸代, 小栗 千里, 小泉 敏之, 來生 知, 廣田 誠, 玉利 正之, 山本 憲幸, 上田 実, 藤内 祝

    頭頸部癌   37 ( 3 )   386 - 389   2011.10

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    進行口腔癌に対する逆行性超選択的動注化学療法は放射線療法との連日同時併用が可能となることから高い抗腫瘍効果が得られる。今回われわれは進行口腔癌に対して根治的逆行性超選択的動注化学放射線療法を施行し、治療効果、累積生存率、局所制御率について検討したので報告する。2003年1月から2009年12月に受診した口腔・顎顔面悪性腫瘍688例中、根治的逆行性超選択的動注化学放射線療法を施行した175症例を対象とした。治療は逆行性超選択的動注化学放射線療法(docetaxel、total 60mg/m2、cisplatin、total 125-150mg/m2、total 50-60Gy)を5〜6週間行った。治療4週後に画像検索および原発の生検にて腫瘍残存の有無の確認を行ったところ、175例中160例(91.4%)がCR、腫瘍残存は15例(8.6%)に認めた。CRであった160例についてはその後の経過観察中に14例(8.0%)の再発を認めた。5年累積生存率および局所制御率はそれぞれ71.6%と82.2%であった。(著者抄録)

    File: 動注CRT.pdf

    DOI: 10.5981/jjhnc.37.386

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  • 吸収性ミニプレートを用いて内視鏡支援下に整復固定した下顎骨関節突起基底部骨折の1例

    岩井 俊憲, 前川 二郎, 安村 和則, 大原 良仁, 柴崎 麻衣子, 大屋 貴志, 矢島 康治, 松井 義郎, 藤内 祝

    日本口腔診断学会雑誌   24 ( 3 )   402 - 406   2011.10

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    21歳男。顔面を殴打され受傷した。前医に搬送され、頭部X線で左側下顎骨関節突起基底部骨折を認められ、同日当科に紹介された。抗菌薬によって消炎を図り、受傷3日後に全身麻酔下で口内法による内視鏡支援下観血的整復固定術を施行した。内視鏡はオリンパス社製の外径4mm、視野方向30°の硬性鏡を使用、プレートはタキロン社製のポリL乳酸吸収性プレート(Fixsorb-MX)を使用し、顔面神経麻痺などの術後合併症なく良好な結果が得られた。

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  • 眼窩頬骨骨折治療後に残遺した顔面非対称に対しナビゲーション支援手術を施行した1例

    岩井 俊憲, 前川 二郎, 安村 和則, 大原 良仁, 大屋 貴志, 柴崎 麻衣子, 矢島 康治, 松井 義郎, 藤内 祝

    日本口腔診断学会雑誌   24 ( 3 )   407 - 412   2011.10

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    38歳男。9ヵ月前に左側眼窩頬骨骨折に対して観血的整復術を受けた。今回、左側の眼球陥凹と頬部平坦化に伴う顔面非対称に対し、メドトロニック社製の光学式ナビゲーションシステム(Stealth Station;以下SS)を用いて手術を行った。SSを使用したことで、理想的な骨切り位置の決定や顔面非対称性の確認が術中容易に行えた。また、本例では眼窩内側壁の手術操作部位が視神経と近接していたが、SSにより視神経との距離を確認しながら安全に手術を施行することができ、良好な結果が得られた。

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  • 頸部郭清術標本中に偶然発見された甲状腺乳頭癌リンパ節転移の1例

    峯村 周, 岩井 俊憲, 廣田 誠, 柴崎 麻衣子, 馬場 隼一, 青木 紀昭, 松井 義郎, 前川 二郎, 藤内 祝

    日本口腔診断学会雑誌   24 ( 3 )   368 - 372   2011.10

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    症例は47歳男性で、左側下顎部の腫脹・疼痛で近歯科を受診し、第二大臼歯の慢性根尖性歯周炎の診断で抜歯されたが腫脹は軽快せず、知覚鈍麻も出現した。左側下顎犬歯から臼後結節に及ぶ潰瘍を伴う50×30mmの腫瘍を認め、造影CTで腫瘍は口底側と頬側へ進展し、腫大した顎下リンパ節と一塊になっており、左側頸部にも腫大リンパ節が認められた。生検で低分化型扁平上皮癌と診断され、術前治療として全身化学放射線療法を施行した。腫瘍は著明に縮小し、患者の希望で同治療を継続したが、終了後の生検で顎骨深部に腫瘍残存を認め、下顎骨区域切除術、左側根治的頸部郭清術、腓骨皮弁による再建術を施行した。病理所見では原発腫瘍の治療効果はPRで、Level IVのリンパ節の一つに甲状腺乳頭癌が認められた。治療前および術後の画像所見で甲状腺腫瘍は認めず、経過観察としたが、1ヵ月後に肺転移が出現した。化学療法は奏効せず、全身状態が悪化して術後4ヵ月目に死亡した。

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  • エコーガイド下に口内法で摘出した耳下腺導管内唾石の1例

    山下 陽介, 岩井 俊憲, 増田 元三郎, 矢島 康治, 柴崎 麻衣子, 大屋 貴志, 大原 良仁, 青木 紀昭, 藤内 祝

    日本口腔診断学会雑誌   24 ( 3 )   384 - 388   2011.10

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    47歳女。2年前に左側頬部の腫脹を自覚し、自然消失後再燃した。発熱と倦怠感、開口障害があり、パノラマX線で下顎枝前縁の前方に不透過像を、CTでは左側咬筋と耳下腺の著明な腫脹、炎症所見を認め、咬筋前縁外側に7×4mmの唾石様物質が存在した。左側急性耳下腺炎、耳下腺導管内唾石症と診断し、抗菌薬の点滴静注で消炎が得られた。耳下腺造影で耳下腺導管は左側下顎枝前縁で拡大されており、口内法による唾石摘出術を施行した。術中に頬部皮膚から探触子を用いてエコーガイド下で唾石の位置を同定し、耳下腺開口部周囲に局所麻酔を行ってブジーを挿入し導管を拡大した。次いでブジーをカテーテルに入れ替え、耳下腺開口部周囲を円状に切開し、モスキートで導管を周囲組織から剥離してメスで切開し唾石を摘出した。導管を吸収糸で縫合し、開口部を元の位置に粘膜縫合した。術後5ヵ月間経過観察し、合併症はなく耳下腺開口部より良好な唾液の流出が認められた。

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  • 下顎の深部埋伏大臼歯に対して頬側皮質骨骨切り術を用いて抜歯した2例

    岩井 俊憲, 大村 進, 君塚 幸子, 青木 紀昭, 山下 陽介, 矢島 康治, 松井 義郎, 藤内 祝

    日本口腔診断学会雑誌   24 ( 3 )   413 - 418   2011.10

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    下顎の深部に埋伏した大臼歯を従来の方法で抜歯した場合には、術中に十分な視野が得られず、また骨の削除量が過大となり術後骨折を生じる可能性がある。さらに、深部埋没歯の抜歯に伴う下歯槽神経麻痺の頻度は通常の抜歯に比べて高いと報告されている。これらのことから、骨の削除量や下歯槽神経麻痺を減らすために下顎枝矢状分割術(SSRO)を用いた抜歯が行われるようになってきたが、SSROは手術侵襲が比較的大きいだけでなく、骨の固定を要し、下顎骨の分割に伴う不整骨折の危険性がある。そこで著者等は低侵襲手術を目指し、頬側皮質骨骨切り術を用いて下顎深部埋伏大臼歯の抜歯を行い、良好な結果が得られたので報告した。本術式には次のような利点がある。1)口腔内から十分な術野が得られ直視下に埋伏歯へアプローチできるため、下歯槽神経血管束を損傷する危険性が低い。2)骨の削除量が少ないため術後骨折の危険性が低い。3)頬側皮質骨の復位により皮質骨の欠損が少なくなるため骨の治癒が早い。4)SSROと異なり骨の固定を必要としない。

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  • 両側上下顎に生じた臼後歯の1例

    小山 千佳, 岩井 俊憲, 渡貫 圭, 飯田 昌樹, 柴崎 麻衣子, 光永 幸代, 廣田 誠, 青木 紀昭, 藤内 祝

    日本口腔診断学会雑誌   24 ( 2 )   206 - 210   2011.6

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    症例は24歳女性で、右側下顎臼後部の疼痛で近医のパノラマX線にて両側上下顎第三大臼歯と臼後歯を指摘され紹介受診した。口腔内所見では全ての第三大臼歯は萠出しておらず、パノラマX線では両側上下顎第三大臼歯は埋伏し、臼後歯は両側性で上顎に2本、下顎に1本ずつ認め、右側第二大臼歯の遠心根は第三大臼歯により吸収されているようであった。CTでは両側上顎臼後歯は上顎洞に近接し、右側上顎第三大臼歯と臼後歯は第二大臼歯の口蓋側に存在していた。両側上下顎埋伏臼後歯・両側上下顎埋伏智歯と診断し、全身麻酔下に両側上下顎埋伏臼後歯、両側上顎と左側下顎第三大臼歯を抜歯した。右側下顎第三大臼歯を抜歯すると第二大臼歯遠心の歯根吸収の可能性から第二大臼歯の保存が困難と判断し、第二大臼歯と臼後歯を抜歯して第三大臼歯に牽引用ブラケットを装着してワイヤーを取り付けた。今後右側下顎第三大臼歯の牽引を行い、咬合平面まで移動させる予定である。

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  • Repair of large fibular defects treated with betatricalcium phosphate blocks retaining autogenous bone marrow cells and enhanced by low-intensity pulsed ultrasound ; report of 5 cases

    TAKEUCHI R, ISHIKAWA H, KUMAGAI K, YAMAGUCHI Y, FUJISAWA T, SAITO T, IWAI T

    33 ( 2 )   468 - 472   2011.5

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  • A case of cancer of the oral floor (T4aN3M0) treated successfully with thermochemoradiotherapy

    Shibasaki Maiko, Mitsudo Kenji, Iwai Toshinori, Yajima Yasuharu, Ohya Takashi, Ohhara Yoshihito, Mitsunaga Sachiyo, Hirota Makoto, Tohnai Iwai

    Journal of Japan Society for Oral Tumors   23 ( 1 )   9 - 15   2011.3

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    File: N3 口底癌.pdf

    DOI: 10.5843/jsot.23.9

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  • 下顎智歯周囲炎を契機に発見された組織球性壊死性リンパ節炎の1例

    根本 敏行, 松井 義郎, 岩井 俊憲, 大橋 勝, 藤内 祝, 新谷 悟

    日本口腔診断学会雑誌   24 ( 1 )   36 - 43   2011.2

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    26歳男。左側下顎智歯周囲歯肉の腫脹と疼痛、左側頸部の腫脹を自覚した。智歯周囲炎と診断されて抗菌薬を投与された。1週間服用したが諸症状は改善せず、39℃以上の発熱も生じた。左側下顎智歯周囲炎および左側頸部リンパ節炎の診断でセフポドキシムプロキセチル投与し、左側下顎智歯周囲炎は消退傾向を示した。しかし、頸部の腫脹、圧痛は変化せず、39℃以上の発熱が持続した。検査所見と臨床経過から壊死性リンパ節炎と臨床診断した。プレドニゾロンの内服投与を開始した。症状は暫時改善傾向を示し、退院した。しかし、再度発熱し、左側よりも右側頸部リンパ節が著しく腫大した。経過から悪性リンパ腫などの腫瘍性病変も完全には否定できなかったため、リンパ節生検術を施行した。病理診断は組織球性壊死性リンパ節炎であった。ロキソプロフェンナトリウムの頓服投与のみで対応し経過観察した。1年以上経過した現在まで再発などなく経過良好である。

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  • A case with carcinoma of the upper gingiva and N3 treated successfully with retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia

    MITSUNAGA Sachiyo, MITSUDO Kenji, IWAI Toshinori, YAJIMA Yasuharu, SHIBASAKI Maiko, OHYA Takashi, OHHARA Yoshihito, HIROTA Makoto, TOHNAI Iwai

    Journal of Japan Society for Oral Tumors   22 ( 4 )   157 - 163   2010.12

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    File: N3.pdf

    DOI: 10.5843/jsot.22.157

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  • A Case of Late Mandibular Fracture Four Weeks after Removal of the Mandibular Third Molar

    UEZONO MASAYOSHI, MATSUI YOSHIRO, IWAI TOSHINORI, MITSUNAGA SACHIYO, NEMOTO TOSIYUKI, CHIKUMARU HIROSHI, HIROTA MAKOTO, AOKI NORIAKI, TOHNAI IWAI

    23 ( 2 )   231 - 235   2010.10

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  • Salvage surgery after intra-arterial chemoradiotherapy using superficial temporal and occipital arteries for advanced oral cancer

    MITSUDO Kenji, IWAI Toshinori, BABA Jyunichi, MITSUNAGA Sachiyo, OGURI Senri, KOIZUMI Toshiyuki, WATANUKI Kei, KIOI Mitomu, HIROTA Makoto, MATSUI Yoshiro, TOHNAI Iwai

    Journal of Japan Society for Oral Tumors   22 ( 3 )   102 - 106   2010.9

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    File: kyuusaisyujyutu.pdf

    DOI: 10.5843/jsot.22.102

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  • A case of delayed cervical lymph node metastasis treated successfully by chemotherapy with TS-1 and thermoradiotherapy

    SHIBASAKI Maiko, MITSUDO Kenji, IWAI Toshinori, TAMAI Naohito, OHARA Yoshihito, MITSUNAGA Sachiyo, WATANUKI Kei, HIROTA Makoto, TOHNAI Iwai

    Journal of Japan Society for Oral Tumors   22 ( 2 )   69 - 73   2010.6

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    File: S-1.pdf

    DOI: 10.5843/jsot.22.69

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  • Superselective intra-arterial infusion via the superficial temporal artery and occipital artery combined with daily concurrent radiotherapy for advanced tongue cancer patient with chronic renal failure : —Analysis of platinum pharmacokinetics—

    Shimizu Mai, Mitsudo Kenji, Iwai Toshinori, Ohhara Yoshihito, Adachi Makoto, Mitsunaga Sachiyo, Hirota Makoto, Matsui Yoshiro, Tohnai Iwai

    Journal of Japan Society for Oral Tumors   22 ( 1 )   45 - 51   2010.3

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    DOI: 10.5843/jsot.22.45

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  • Daily concurrent preoperative chemoradiotherapy using superselective intra-arterial infusion via superficial temporal artery for advanced oral cancer : Histological evaluation of metastatic cervical lymph nodes

    MITSUDO Kenji, YAMAMOTO Noriyuki, SHIGETOMI Toshio, NISHIGUCHI Hiroaki, FURUE Hiroki, IWAI Toshinori, HIROTA Makoto, MATSUI Yoshiro, UEDA Minoru, TOHNAI Iwai

    Journal of the Japanese Stomatological Society   59 ( 1 )   1 - 8   2010.1

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    File: 動注CRT 頸部メタ.pdf

    DOI: 10.11277/stomatology.59.1

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  • A case of mucoepidermoid carcinoma of the oral floor treated successfully with preoperative daily concurrent chemoradiotherapy using superselective intra-arterial infusion via the superficial temporal artery

    BABA Junichi, MITSUDO Kenji, IWAI Toshinori, FUKUI Takafumi, MITSUNAGA Sachiyo, WATANUKI Kei, HIROTA Makoto, MATSUI Yoshiro, TOHNAI Iwai

    21 ( 4 )   265 - 271   2009.12

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    DOI: 10.5843/jsot.21.265

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  • Superselective intra-arterial infusion via the superficial temporal artery and occipital artery for gingival carcinoma of the mandible : simultaneous catheter placement to the maxillary artery and facial artery

    IWAI Toshinori, MITSUDO Kenji, FUKUI Takafumi, UEZONO Masayoshi, BABA Junichi, OYA Takashi, OHARA Yoshihito, SHOJI Shihomi, MITSUNAGA Sachiyo, ADACHI Makoto, WATANUKI Kei, CHIKUMARU Hiroshi, HIROTA Makoto, MATSUI Yoshiro, TOHNAI Iwai

    Toukeibu Gan   35 ( 3 )   273 - 278   2009.10

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    File: STA OA.pdf

    DOI: 10.5981/jjhnc.35.273

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  • A Case of Right Brachiocephalic Venous Thrombosis Associated with Central Venous Catheter Inserted from the Median Cubital Vein after Reconstruction of Oral Cancer

    YAMAGISHI Momoko, MATSUI Yoshiro, IWAI Toshinori, BABA Junichi, SHOJI Shihomi, MITSUNAGA Sachiyo, HIROTA Makoto, MITSUDO Kenji, TOHNAI Iwai

    37 ( 3 )   319 - 320   2009.7

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  • A case of endoscopically-assisted removal for cystic lesion of the mandible

    IWAI Toshinori, MATSUI Yoshiro, MITSUNAGA Sachiyo, WATANUKI Kei, NEMOTO Toshiyuki, TOHNAI Iwai

    Japanese journal of oral and maxillofacial surgery   55 ( 4 )   203 - 207   2009.4

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    File: KCOT.pdf

    DOI: 10.5794/jjoms.55.203

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  • Catheter placement via the occipital artery to achieve superselective intra-arterial chemotherapy for oral cancer

    IWAI Toshinori, MITSUDO Kenji, FUKUI Takafumi, BABA Junichi, UEZONO Masayoshi, OHARA Yoshihito, SHOJI Shihomi, MITSUNAGA Sachiyo, ADACHI Makoto, WATANUKI Kei, OHTA Shinsuke, CHIKUMARU Hiroshi, HIROTA Makoto, MATSUI Yoshiro, TOHNAI Iwai

    Toukeibu Gan   34 ( 4 )   508 - 512   2008.12

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    File: OA.pdf

    DOI: 10.5981/jjhnc.34.508

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  • 顎矯正手術における超音波骨メスの使用経験

    岩井 俊憲, 松井 義郎, 森田 淳平, 小澤 知倫, 安村 和則, 三上 太郎, 藤内 祝, 前川 二郎

    形成外科   51 ( 11 )   1319 - 1325   2008.11

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    超音波骨メスを用いて顎矯正手術を施行した12例を対象に術後成績を検討した。術式は、Le Fort I型骨切り術、下顎枝矢状分割術、下顎枝垂直骨切り術、下顎骨延長術、おとがい形成術であった。その結果、超音波骨メスはバーやソーに比べ切削効率が悪いため骨切りに時間を要したが、全例において安全に骨切りすることが出来た。また、軟組織を損傷しないため、術者は安心して手術を行うことが出来た。超音波骨メスはバーやソーに比べ血管や神経を損傷し難い特徴を持つため、各術式において血管および神経の近傍を骨切りせざるを得ない時に特に有用であり、顎矯正手術の安全性の向上が図れると考えられた。

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  • Transoral reduction and fixation of a subcondylar fracture assisted by endoscopy : report of a case

    UEZONO Masayoshi, MATSUI Yoshiro, IWAI Toshinori, ADACHI Makoto, MAEGAWA Jiro, TOHNAI Iwai

    Japanese Journal of Oral & Maxillofacial Surgery   54 ( 11 )   607 - 610   2008.11

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    File: Condyle Endoscope.pdf

    DOI: 10.5794/jjoms.54.607

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  • A Case of Deep Venous Thrombosis after Mandibular Reconstruction with a Free Vascularized Fibula Flap

    YAMAGISHI Momoko, MATSUI Yoshiro, IWAI Toshinori, SHOJI Shihomi, WATANUKI Kei, FUKUI Takafumi, MITSUDOU Kenji, MAEGAWA Jiro, TOHNAI Iwai

    36 ( 5 )   569 - 570   2008.10

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  • Hemangioma Arising in the Temporal Muscle : Report of a Case

    BABA JUNICHI, MATSUI YOSHIRO, IWAI TOSHINORI, YASUMURA KAZUNORI, MAEGAWA JIRO, TOHNAI IWAI

    21 ( 2 )   305 - 309   2008.10

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  • A Case of Inverted Impacted Supernumerary Tooth that Projected from the Inferior Border of the Mandible During Follow-up Reviewed

    YAMAGISHI MOMOKO, MATSUI YOSHIRO, IWAI TOSHINORI, MASUDA GENZABURO, HASEGAWA YUKIO, AOKI NORIAKI, TOHNAI IWAI

    21 ( 2 )   288 - 291   2008.10

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  • A Case of Mandibular Third Molar with Perforation of the Inferior Alveolar Nerve through the Root Reviewed

    IWAI TOSHINORI, MATSUI YOSHIRO, YAMAGUCHI TOMOKO, MITSUNAGA SACHIYO, HIROTA MAKOTO, AOKI NORIAKI, HASEGAWA YUKIO, MASUDA GENZABURO, TOHNAI IWAI

    21 ( 2 )   246 - 248   2008.10

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  • The use of ultrasonic bone scalpel during treatment for ameloblastoma of the mandible

    MORITA Jumpei, MATSUI Yoshiro, IWAI Toshinori, SHOJI Shihomi, ADACHI Makoto, FUKUI Takafumi, WATANUKI Kei, MITSUDO Kenji, TOHNAI Iwai

    20 ( 3 )   151 - 156   2008.9

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    File: SONOPET.pdf

    DOI: 10.5843/jsot.20.151

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  • A Case of Endoscopic-assisted Reduction and Fixation for Subcondylar Fracture of the Mandible

    IWAI TOSHINORI, MATSUI YOSHIRO, WATANUKI KEI, YASUMURA KAZUNORI, MAEGAWA JIRO, TOHNAI IWAI

    21 ( 1 )   59 - 62   2008.3

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  • Navigation Aided Surgery with an Endoscope for Venous Malformation in the Masticator Space

    IWAI TOSHINORI, MATSUI YOSHIRO, YASUMURA KAZUNORI, ADACHI MAKOTO, MAEGAWA JIRO, TOHNAI IWAI

    21 ( 1 )   63 - 68   2008.3

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  • Clinical Use of Ultrasonic Bone Scalpel for Sinus Floor Augmentation

    IWAI TOSHINORI, MATSUI YOSHIRO, AOKI NORIAKI, OZAWA TOMOMICHI, HIROTA MAKOTO, MIZUKI NOBUYUKI, TOHNAI IWAI

    21 ( 1 )   40 - 44   2008.3

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  • Clinico-statistical Analysis on Anterior Segmental Osteotomy

    IWAI TOSHINORI, MASUDA GENZABURO, SHOJI SHIHOMI, WATANUKI KEI, MATSUI YOSHIRO, TOHNAI IWAI

    20 ( 2 )   225 - 229   2007.10

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  • 顔面骨骨折に対するナビゲーション支援手術の経験

    岩井 俊憲, 松井 義郎, 安村 和則, 渡貫 圭, 藤内 祝, 前川 二郎

    形成外科   50 ( 9 )   1033 - 1039   2007.9

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    ナビゲーション支援手術を施行した顔面骨骨折11例の治療成績を検討した。11例中10例は術後の顔貌に満足し、術後に撮影したCTで顔面の対称性を顔面正中からの距離計測にて数ヶ所ずつ確認したところ、顔面の左右差は全例で1.6mm以内と良好な顔面の対称性が得られていた。しかし、顔面多発骨折の症例では術中に術者がリファレンスフレームと接触し、実際の操作部位とナビゲーション画像内のプローブ先端の位置にずれを生じたため、ナビゲーション支援手術が不可能となった。そのため、術者の主観で整復位を決定したが、完全な顔面の対称性は得られず、術後患側の眼球陥凹および頬部平坦化を認めた。ナビゲーションシステムを用いることで、術者の経験に頼らず理想的な骨切り部位や骨片の整復位が決定でき、術中に顔面の対称性を客観的に確認することが可能であった。

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  • Anesthetic Management of a Jaw Deformities Patient with Antiphospholipid Antibody Syndrome Reviewed

    FURUSE Satori, KAMIYA Yoshitaka, IWAI Toshinori, SOMA Rihito, WATANUKI Kei, OHTA Shinsuke, MATSUI Yoshiro, GOTO Takahisa, TOHNAI Iwai

    35 ( 3 )   402 - 403   2007.7

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  • A case of emphysema arising on face, neck, and mediastinum after CO_2 laser irradiation for an alveolar abscess

    HIRASHITA Koki, MATSUI Yoshiro, OZAWA Tomomichi, IWAI Toshinori, ISHIBASHI Katsunori, TOHNAI Iwai

    Japanese Journal of Oral & Maxillofacial Surgery   53 ( 5 )   319 - 323   2007.5

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    File: laser.pdf

    DOI: 10.5794/jjoms.53.319

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  • Navigation-aided Removal of a Tooth Displaced into the Maxillary Sinus : Report of a Case

    IWAI TOSHINORI, MATSUI YOSHIRO, SHOJI SHIHOMI, FURUSE SATORI, CHIKUMARU HIROSHI, TOHNAI IWAI

    20 ( 1 )   142 - 146   2007.3

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  • Fluoroscopic Removal of Foreign Body in the Mandibular Canal : Report of a Case

    IWAI TOSHINORI, OMURA SUSUMU, OKAMOTO YOSHIYUKI, UMINO SATOSHI, MATSUI YOSHIRO, TOHNAI IWAI

    20 ( 1 )   152 - 155   2007.3

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  • A case of arteriovenous malformation in the buccal region : usefulness of three-dimensional CT angiography

    IWAI Toshinori, MATSUI Yoshiro, MAEGAWA Jiro, YASUMURA Kazunori, OZAWA Tomomichi, TOHNAI Iwai

    Japanese Journal of Oral & Maxillofacial Surgery   53 ( 2 )   103 - 107   2007.2

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    File: AVM.pdf

    DOI: 10.5794/jjoms.53.103

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  • A case of vermilion reconstruction using a facial artery musculomucosal flap

    IWAI Toshinori, MATSUI Yoshiro, MAEGAWA Jiro, YASUMURA Kazunori, AOKI Shinjiro, TOHNAI Iwai

    Japanese Journal of Oral & Maxillofacial Surgery   52 ( 12 )   748 - 751   2006.12

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    File: FAMM flap.pdf

    DOI: 10.5794/jjoms.52.748

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  • 眼瞼Merkel細胞癌の2例

    安村 和則, 前川 二郎, 岩井 俊憲, 牧野 太郎, 岩瀬 わかな, 鳥飼 勝行, 佐々木 毅

    臨床眼科   60 ( 12 )   1943 - 1949   2006.11

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    症例1(75歳女性)。左上眼瞼腫瘤の急速な増大を主訴とした。症例2(83歳女性)。左下眼瞼腫瘤の急速な増大を主訴とした。両症例とも原発巣を切除し、欠損部は局所皮弁で再建した。症例1は高齢のため、症例2は重度の認知症と高齢のため頸部郭清術は施行しなかったが、症例1に対しては術後放射線照射を行なった。その結果、局所再発はなかったものの、術後10ヵ月目、後頸部に多発性皮下腫瘤が再発し、緊急入院3日後に患者は死亡となった。一方、症例2は術後5ヵ月後、左顔面に多発性皮下腫瘤が再発し、1ヵ月後、死亡となった。以上、本疾患は広範囲切除と所属リンパ節郭清を行い、術後放射線治療を行うほうがよいとされるが、その際、原発巣に腫瘍を残さない確実な切除と適切な再建術が、その生存中の良好なQOLを得る上で重要だと考えられた。

    DOI: 10.11477/mf.1410101020

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  • Anesthetic Management of a Patient with Cornelia de Lange Syndrome

    FURUSE Satori, SAITO Tomokatsu, IWAI Toshinori, KAMIYA Yoshitaka, MIYASHITA Tetsuya, MATSUI Yoshiro, GOTO Takahisa, TOHNAI Iwai

    34 ( 5 )   526 - 527   2006.10

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  • A Case of Subcutaneous and Mediastinal Emphysema following Nasotracheal Intubation

    IWAI Toshinori, OKI Hiroshi, FURUSE Satori, OMURA Susumu, OKAZAKI Kaoru, TOHNAI Iwai

    34 ( 5 )   524 - 525   2006.10

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  • A case of widespread subcutaneous and mediastinal emphysema following extraction of a mandibular third molar : Changes in emphysema on CT scans

    IWAI Toshinori, OMURA Susumu, OKAMOTO Yoshiyuki, SAITO Tomokatu, UMINO Satoshi, FUJITA Kiyohide

    Japanese Journal of Oral & Maxillofacial Surgery   52 ( 3 )   191 - 194   2006.3

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    File: CT emphysema.pdf

    DOI: 10.5794/jjoms.52.191

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  • A case of glandular odontogenic cyst arising in the right third molar region of the mandible

    OKAMOTO Yoshiyuki, KAWADA Kensuke, IWAI Toshinori, OZAWA Mikio, KIKUCHI Yoshinao, ISHIKAWA Yoshimi

    Japanese Journal of Oral & Maxillofacial Surgery   52 ( 1 )   11 - 14   2006.1

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    DOI: 10.5794/jjoms.52.11

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  • A case of hereditary angioedema : special reference to perioperative management

    IWAI Toshinori, CHIKUMARU Hiroshi, HIROTA Makoto, WATANUKI Kei, KAWABE Ryoichi, FUJITA Kiyohide

    Japanese Journal of Oral & Maxillofacial Surgery   51 ( 5 )   260 - 263   2005.5

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    File: HAE.pdf

    DOI: 10.5794/jjoms.51.260

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  • Prevention of Pulmonary Embolism at Yokohama City University Hospital : Perioperative Management in Oral and Maxillofacial Surgery

    IWAI Toshinori, HIRASHITA Koki

    33 ( 2 )   219 - 223   2005.4

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  • Anesthetic Management for Partial Tongue Resection in a Patient with Beckwith-Wiedemann Syndrome Reviewed

    IWAI Toshinori, NAGAI Shoichiro, HIRASHITA Koki, MIYASITA Tetsuya, YAMADA Yoshitsugu

    33 ( 2 )   273 - 274   2005.4

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  • A case of tetanus without any apparent history of trauma

    IWAI Toshinori, AOKI Shinjiro, OKAMOTO Yoshiyuki, HIROTA Makoto, KAWABE Ryoichi, FUJITA Kiyohide

    Japanese Journal of Oral & Maxillofacial Surgery   51 ( 3 )   128 - 131   2005.3

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    File: 破傷風.pdf

    DOI: 10.5794/jjoms.51.128

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Presentations

  • In-house manufacturing cutting guideを用いた顎骨切除とミニプレート/自家骨による顎骨再建 Invited

    岩井俊憲

    第41回日本口腔腫瘍学会総会・学術大会,シンポジウム「口腔腫瘍に対するcomputer assisted surgery(CAS)-シミュレーションを反映した顎骨切除・再建-」  2023.1 

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    Event date: 2023.1

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 横浜市立大学附属病院における下顎再建シミュレーション

    岩井俊憲

    第32回日本シミュレーション外科学会,シンポジウム「下顎再建のシミュレーション」  2022.12 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

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  • 口腔顎顔面領域における低侵襲手術の確立 Invited

    岩井俊憲

    第76回日本口腔科学会学術集会,指名報告  2022.4 

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    Event date: 2022.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • 後戻りリスクのある骨格性下顎後退症の治療-上顎後上方移動での対応- Invited

    岩井俊憲

    第6回冬期口腔外科臨床研究会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • 口腔外科領域におけるSPIOを用いたSNNS Invited

    岩井俊憲

    第22回SNNS研究会学術集会,シンポジウム「新規トレーサーを用いた SNNS の現状と展望」  2020.11 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • ゴールから始める顎再建-Computer Assisted Mandibular Reconstruction- Invited

    岩井俊憲

    第65回日本口腔外科学会総会・学術大会,シンポジウム「ゴールから始める顎再建」  2020.11 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • Computer assisted oral and maxillofacial surgery Invited

    Iwai T

    7th Beiennial Congress of the ADT  2019.6 

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    Event date: 2019.6

    Language:English   Presentation type:Oral presentation (invited, special)  

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  • Endoscopically-assisted oral and maxillofacial surgery: technical note Invited

    Iwai T

    2009.10 

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  • Navigation Surgery in OMS Invited International conference

    Iwai T

    The 51st Congress of the Korean Association of Oral and Maxillofacial Surgeons, Special lecture  2010.4 

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    Presentation type:Oral presentation (invited, special)  

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  • Endoscopically-assisted transoral approach with angulated drill and screwdriver Invited

    Iwai T

    2009.10 

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  • 口腔顎顔面外科手術におけるナビゲーション-下顎への適用-

    岩井俊憲, 小栗千里, 大屋貴志, 光藤健司, 藤内 祝

    第62回日本口腔外科学会総会・学術大会,ワークショップ「口腔外科領域におけるナビゲーション」  2017.10 

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  • 口腔外科領域における内視鏡手術-低侵襲手術を目指して-

    岩井俊憲, 小栗千里, 光藤健司, 藤内 祝

    第62回日本口腔外科学会総会・学術大会,ワークショップ「口腔外科領域における内視鏡」  2017.10 

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  • 口腔顎顔面領域におけるcomputer assisted simulation and surgery-現状と将来展望- Invited

    岩井俊憲

    第62回日本口腔外科学会総会・学術大会,シンポジウム「最先端technologyの口腔外科への応用」  2017.10 

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  • 顎矯正手術におけるsimulationとCAD/CAM wafer

    岩井俊憲, 大村 進, 林 雄一郎, 山下陽介, 高須 曜, 村田彰吾, 藤内 祝

    第62回日本口腔外科学会総会・学術大会,ワークショップ「手術シミュレーション」  2017.10 

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  • New 3D mapping of sentinel lymph node in oral cancer Invited

    岩井俊憲

    SOMATOM Symposium 2018  2018.8 

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  • 横浜市立大学における顎変形症治療のイノベーション Invited

    岩井俊憲, 大村 進

    第63回日本口腔外科学会総会・学術大会,シンポジウム「口腔外科のイノベーション-顎変形症-」  2018.11 

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  • 口腔顎顔面領域におけるsimulation surgery Invited

    岩井俊憲

    第27回日本シミュレーション外科学会,シンポジウム「様々な領域のシミュレーション外科」  2017.11 

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  • 軟組織腫瘍/囊胞・顎下腺疾患に対する内視鏡を用いた低侵襲手術 Invited

    岩井俊憲

    第3回冬期口腔外科臨床研究会  2018.2 

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  • Computer assisted oral and maxillofacial surgery Invited

    Iwai T

    第63回日本口腔外科学会総会・学術大会,国際シンポジウム(日韓セッション)「3D digital technology for oral & maxillofacial surgery」  2018.11 

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  • VR/MRの歯科口腔外科手術への応用 Invited

    岩井俊憲

    第3回日本顎顔面再建先進デジタルテクノロジー学会学術講演会,シンポジウム「CG/VR/ARの医療応用の最前線:現状の課題と今後の展望」  2018.12 

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  • Computer assisted maxillofacial simulation and surgery Invited

    岩井俊憲

    Materialise Japan Conference 2015, Invited lecture  2015.9 

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  • Functional understanding of occlusion and temporo-mandibular joint in reconstruction of jaws Invited

    Iwai T

    AOCMF Focused Workshop on Reconstruction, Invited lecture  2015.4 

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  • Overview of the mandibular reconstruction Invited

    Iwai T

    AOCMF Focused Workshop on Reconstruction, Invited lecture  2015.4 

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  • 大臼歯歯根嚢胞に対する内視鏡下歯根端切除術 Invited

    岩井俊憲

    第60回日本口腔外科学会総会・学術大会,シンポジウム「口腔外科小手術Up-to-Date」  2015.10 

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  • 顎下部・頸部病変の鑑別診断のポイントと低侵襲手術のコツ

    岩井俊憲

    第60回日本口腔外科学会総会・学術大会,若手口腔外科医のためのミニレクチャー  2015.10 

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  • 下顎骨関節突起骨折に対するSurgical Approach-低侵襲手術を目指して-

    岩井俊憲

    第59回日本口腔外科学会総会・学術集会,若手口腔外科医のためのミニレクチャー  2014.10 

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  • 顎下腺唾石に対する低侵襲手術-内視鏡下唾石摘出術から内視鏡支援下顎下腺摘出術まで- Invited

    岩井俊憲

    第59回日本口腔外科学会総会・学術集会,シンポジウム「口腔外科領域での内視鏡の応用」  2014.10 

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  • 口腔顎顔面領域における内視鏡を用いた低侵襲手術-導入のためのA to Z-

    岩井俊憲

    第58回日本口腔外科学会総会・学術集会,若手口腔外科医のためのミニレクチャー  2013.10 

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  • Novel computer assisted simulation and navigation in oral and maxillofacial surgery

    岩井俊憲

    第58回日本口腔外科学会総会・学術大会,国際シンポジウム 第2会日独セッション  2013.10 

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  • Postoperative management Invited

    Iwai T

    AOCMF Course- Focused in Osteotomy  2016.10 

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  • Complications Invited

    Iwai T

    AOCMF Course- Focused in Osteotomy  2016.10 

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  • 術前計画の実際 Invited

    岩井俊憲

    MATRIX ROUND TABLE 2016-ORTHOGNATHIC SURGERY  2016.6 

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  • Design and function of plate and screws (Standard/locking system) Invited

    Iwai T

    AOCMF Course- Focused in Osteotomy  2016.10 

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  • Computer assisted surgical simulation and surgery in orthognathic surgery Invited International conference

    Iwai T

    The 55th Congress of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons  2016.11 

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  • 口腔顎顔面外科手術における3Dモデルとナビゲ-ションの適応

    岩井俊憲, 石黒敬大, 藤内 祝

    第60回日本口腔外科学会総会・学術大会,ワークショップ「3Dモデル①顎変形」  2015.10 

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  • 口腔顎顔面外科手術における3Dプリンターの臨床応用

    岩井俊憲

    第2回日本顎顔面再建先進デジタルテクノロジー学会,パネルディスカッション「3Dプリンターの臨床応用」  2015.11 

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  • CT lymphographyによるセンチネルリンパ節マッピングとICGを用いた小切開によるセンチネルリンパ節生検 Invited

    Toshinori Iwai

    2016.1 

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  • Prosthesis and dental implant for maxillary reconstruction Invited

    Iwai T

    AOCMF Focused Workshop on Reconstruction, Invited lecture  2015.4 

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  • Computer assisted simulation and navigation in maxillofacial surgery

    岩井俊憲, 鍵本慎太郎, 三上太郎, 前川二郎

    第25回日本シミュレーション外科学会,シンポジウム「先進技術の臨床応用」  2015.10 

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  • Computer-assisted mandibular surgery Invited International conference

    Iwai T

    AOCMF Advances Workshop on Navigation and Computer Assisted Surgery, Invited lecture  2013.2 

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  • Computer assisted maxillofacial simulation and surgery

    岩井俊憲

    第2回日本顎顔面再建先進デジタルテクノロジー学会,シンポジウム「顎顔面領域におけるデジタル技術のstate-of-art」  2015.11 

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  • Safe osteotomy and accurate repositioning of the maxilla in Le Fort I osteotomy Invited

    Toshinori Iwai

    2017.6 

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  • 口腔顎顔面領域におけるsimulationとcomputer assisted surgery Invited

    岩井俊憲

    Materialise Japan Medical Congress  2017.10 

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  • ナビゲーションシステムを用いた口腔顎顔面外科手術 Invited

    岩井俊憲

    第41回日本口蓋裂学会総会・学術集会,ランチョンセミナー  2017.5 

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  • Computer assisted simulation in oral and maxillofacial surgery Invited International conference

    Iwai T

    6th Triennial Congress of Advanced Digital Technology in Head and Neck Reconstruction, Invited lecture  2017.6 

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  • 「3D外科矯正シュミレーションの活用」 Computer assisted simulation and surgery in orthognathic surgery Invited

    岩井俊憲

    Dolphin Meeting Japan 2016  2016.12 

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  • Intraoral approach for temporomandibular lesion Invited

    岩井俊憲

    第2回冬期口腔外科臨床研究会  2017.3 

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  • Overview of the mandibular reconstruction Invited

    Iwai T

    AOCMF Focused Course-Principles in Reconstruction  2017.5 

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  • Prosthesis and dental implant for maxillary reconstruction Invited

    Iwai T

    AOCMF Focused Course-Principles in Reconstruction  2017.5 

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  • Accurate maxillary repositioning in Le Fort I osteotomy Invited

    岩井俊憲

    S.O.R.G.- Far East Expert Meeting-顎変形症の未来を考える-  2017.3 

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  • Functional understanding of occlusion and temporo-mandibular joint in reconstruction of jaws Invited

    Iwai T

    AOCMF Focused Course-Principles in Reconstruction  2017.5 

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  • Cystic ameloblastomaに対する低侵襲アプローチ Invited

    岩井俊憲

    第4回冬季口腔外科臨床研究会  2019.2 

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  • Complications Invited

    Iwai T

    AOCMF Focused Course- Principles in Osteotomy  2019.10 

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  • Accurate maxillary repositioning technique Invited

    Iwai T

    AOCMF Focused Course- Principles in Osteotomy  2019.10 

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  • 関節頭骨折に対する観血的整復固定術 Invited

    岩井俊憲

    第73回NPO法人日本口腔科学会学術集会,ワークショップ「関節頭骨折の診断と治療~保存療法から開放手術まで~」  2019.4 

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  • 早期口腔癌に対する磁性造影剤を用いたMR lymphographyと磁気プローブを用いたセンチネルリンパ節生検 Invited

    岩井俊憲

    第4回バイオマグネティック専門研究会  2019.12 

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  • 下顎骨関節突起骨折に対するsurgical approach-低侵襲手術を目指して-

    岩井俊憲

    第64回日本口腔外科学会総会・学術大会,ワークショップ「外傷(関節突起骨折に対するアプローチ)」  2019.10 

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  • 上顎大臼歯歯根嚢胞に対する内視鏡下歯根端切除術-患歯温存を目指して- Invited

    岩井俊憲

    第64回日本口腔外科学会総会・学術大会,シンポジウム「続・上顎洞に関連する耳鼻咽喉科医,歯内療法医とのディスカッション」  2019.10 

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  • 口腔顎顔面領域へのcomputer assisted surgeryの導入 Invited

    岩井俊憲

    第3回日本口腔顎顔面外傷学会認定教育研修会,「顎顔面外傷-最近の進歩」  2021.8 

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  • 下顎骨関節突起骨折に対する内視鏡アプローチ Invited

    岩井俊憲

    第7回冬期口腔外科臨床研究会  2023.2 

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  • 横浜市立大学における下顎枝矢状分割術中の近位骨片の位置決め法 Invited

    岩井俊憲

    第78回日本口腔科学会学術集会,シンポジウム「下顎骨切り術における顎関節の位置の決め方」  2024.7 

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  • Surgical method for accurate maxillary posterior repositioning in Le Fort I osteotomy Invited

    岩井俊憲

    第33回日本顎変形症学会総会・学術大会,シンポジウム「上顎骨後方移動の現状」  2023.6 

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  • 横浜市立大学における顎矯正手術の変遷

    岩井俊憲

    第34回日本顎変形症学会総会・学術大会,シンポジウム「顎矯正手術の進歩-術式の基本と改変ならびにその成果-」  2024.6 

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  • 口腔顎顔面領域におけるcomputer assisted surgery-simulation surgeryからnavigation surgeryへのパラダイムシフト- Invited

    Iwai T

    2008.11 

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  • 口腔癌に対する逆行性超選択的動注化学放射線療法-PET-CTによる治療効果判定とfollow-up- Invited

    Iwai T, Mitsudo K, Hirota M, Matsui Y, Tohnai I

    2009.10 

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  • Computer-assisted Surgery (CAS)を検証する-顎変形症治療におけるナビゲーションシステムの臨床応用-

    Iwai T, Matsui Y, Tohnai I

    2007.6 

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  • Indications and limitations of navigation in orthognathic surgery Invited

    Iwai T, Omura S, Matsui Y, Tohnai I

    2012.6 

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  • 新しい低侵襲な唾石摘出術-従来法から内視鏡下摘出術へ-

    Toshinori Iwai

    2012.10 

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  • 口腔顎顔面領域におけるComputer Assisted Surgery(CAS)

    岩井俊憲

    第55回日本口腔外科学会総会・学術集会,若手口腔外科医のためのミニレクチャー  2010.10 

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  • 下顎骨関節突起骨折に対するsurgical approach-内視鏡支援による低侵襲手術を中心に-

    岩井俊憲

    第56回日本口腔外科学会総会・学術集会,若手口腔外科医のためのミニレクチャー  2011.10 

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  • Computer assisted simulation and surgery in oral and maxillofacial region Invited

    岩井俊憲

    Materialise Japan Conference 2013,Invited lecture  2013.9 

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  • Computer-aided mandibular reconstruction Invited International conference

    Iwai T

    AOCMF Advances Workshop on Navigation and Computer Assisted Surgery, Invited lecture  2013.2 

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Awards

  • 指名報告

    2022.4   日本口腔科学会   口腔顎顔面領域における低侵襲手術の確立

    岩井俊憲

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  • 学長表彰奨励賞

    2018.3   横浜市立大学  

    岩井俊憲

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Research Projects

  • 口腔癌頸部リンパ節微少転移の革新的早期診断法の確立

    2025 - 2027

    文部科学省  科学研究費補助金  基盤研究(C)

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  • 口腔癌に対する磁気法によるセンチネルリンパ節生検の確立-RI法との非劣性試験-

    2021 - 2024

    文部科学省  科学研究費補助金  基盤研究(C)

    岩井俊憲

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  • 磁性造影剤と磁気プローブを用いた新しい口腔癌センチネルリンパ節同定法の確立

    2018 - 2022

    文部科学省  科学研究費補助金  基盤研究(C)

    岩井俊憲

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  • 口腔癌に対する新規選択的薬物送達による革新的低侵襲治療法の開発

    2016 - 2018

    文部科学省  科学研究費補助金  基盤研究(B)

    藤内 祝,岩井俊憲,佐藤 格,大島まり,大屋貴志

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  • 顎矯正手術後の睡眠呼吸障害を考慮した新しい数値流体解析を用いた治療計画の確立

    Grant number:15K11260  2015 - 2018

    文部科学省  科学研究費補助金  基盤研究(C)

    大村 進,岩井俊憲

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

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  • 磁性体造影剤(SPIO)を用いた口腔癌センチネルリンパ節の同定と転移の検索

    Grant number:15K11298  2015 - 2018

    文部科学省  科学研究費補助金  基盤研究(C)

    岩井俊憲,藤内 祝

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

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  • 進行口腔癌に対する超選択的動注法のための新しい血流維持型血管内視鏡の開発

    Grant number:15K15745  2015 - 2017

    文部科学省  科学研究費補助金  挑戦的萌芽研究

    藤内 祝,岩井俊憲,大屋貴志,板宮朋基

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

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  • 口腔顎顔面領域におけるICGを用いた蛍光ナビゲーション手術の確立

    Grant number:26463020  2014 - 2017

    文部科学省  科学研究費補助金  基盤研究(C)

    不破信和,岩井俊憲,藤内 祝

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

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  • 先端医科学研究センターにおける医療応用を目指した開発型研究

    2013 - 2015

    横浜市立大学  戦略的研究推進費 

    谷口英樹,岩井俊憲

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    Grant type:Competitive

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  • ICGと近赤外線内視鏡を用いた小切開による低侵襲なセンチネルリンパ節生検の確立

    Grant number:25670865  2013 - 2014

    文部科学省  科学研究費補助金  挑戦的萌芽研究

    藤内 祝,岩井俊憲

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

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  • 患者固有データを用いた流体シミュレーションによるオーダーメイド動注化学療法の開発

    Grant number:24390459  2012 - 2014

    文部科学省  科学研究費補助金  基盤研究(B)

    藤内 祝,岩井俊憲,光藤健司,大島まり

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\7280000 ( Direct Cost: \5600000 、 Indirect Cost:\1680000 )

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  • ノートパソコンとのUSB接続によるポータブル歯科・口腔外科内視鏡システムの開発

    Grant number:24792240  2012 - 2013

    文部科学省  科学研究費補助金  若手研究(B)

    岩井俊憲

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • 内視鏡を用いた低侵襲な歯科・口腔外科治療の普及を目指したファイバースコープシステムとバーチャルシミュレーターの開発

    2012 - 2013

    横浜市立大学  先端医科学研究センター研究開発プロジェクト(第Ⅲ期)若手育成プログラム 

    岩井俊憲

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    Authorship:Principal investigator  Grant type:Competitive

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  • 医工産学連携による革新的手術シミュレーション・ナビゲーションシステムの開発研究

    2012 - 2013

    横浜市立大学  先端医科学研究センター研究開発プロジェクト(第Ⅲ期)シーズ開発プログラム 

    窪田吉信,岩井俊憲

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    Grant type:Competitive

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  • 流体解析シミュレーションによる顎骨移動前後の気道形態と呼吸機能の検討

    Grant number:23592933  2011 - 2013

    文部科学省  科学研究費補助金  基盤研究(C)

    大村 進,岩井俊憲,大島まり,藤内 祝

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\5330000 ( Direct Cost: \4100000 、 Indirect Cost:\1230000 )

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  • 口腔癌に対する超選択的動注法のための複合画像誘導手法による手術支援システムの開発

    Grant number:23592932  2011 - 2013

    文部科学省  科学研究費補助金  基盤研究(C)

    不破信和, 藤内 祝, 光藤 健司, 岩井 俊憲

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\5330000 ( Direct Cost: \4100000 、 Indirect Cost:\1230000 )

    口腔癌患者に対する超選択的動注法のための手術支援システムを構築するにはナビゲーションシステムの精度を向上させるだけでは不十分であり,術中の患者頭部の位置変化による頸動脈の変形も考慮する必要がある.そのため,本年度は頸動脈血管変形について研究を行った.6人の口腔癌患者に対して64列マルチスライスCTを用いて眼窩上縁からC6までCT angiographyを治療前後で撮影した.この画像データは頭部を固定していないため,骨と血管の位置は変化していることになる.そのDICOMデータを用いて,ソフトウェア(Mimics)上で頸動脈,顎顔面骨,下顎骨と頸椎(C1~C4)をセグメンテーションした.セグメンテーションした後,顎顔面骨を基準に重ね合わせを行うことで,頸動脈の各分枝の5つの分岐点における頭部の位置変化(下顎骨や頸椎の位置変化)による頸動脈の偏位を検討した.頸動脈の偏位はカテーテルナビゲーションを行ううえで重要な誤差因子となることが示唆された.そのため,頸動脈の位置変化まで予測できるようなナビゲーションシステムを構築するために,今後頸動脈変形も加味したアルゴリズムを開発し,誤差の少ないナビゲーションシステムを開発していく必要があると思われた.本年度の研究成果は英文誌(Biomed Eng Online. 2012 Sep 4;11:65. doi: 10.1186/1475-925X-11-65.)に論文発表した.

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  • 化学放射線療法前後の頸部リンパ流路の同定とICGを用いた潜在転移リンパ節の探索

    Grant number:23659954  2011 - 2012

    文部科学省  科学研究費補助金  挑戦的萌芽研究

    藤内 祝,岩井俊憲,光藤健司

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

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  • バーチャルリアリティと3次元触覚インターフェイスを用いた内視鏡支援下頸部手術訓練システムの開発

    2011

    財団法人横浜総合医学振興財団  萌芽的研究助成 

    岩井俊憲

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    Authorship:Principal investigator  Grant type:Competitive

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  • 内視鏡支援下口腔外科手術を普及させるための安価な内視鏡システムの開発

    Grant number:22791998  2010 - 2011

    文部科学省  科学研究費補助金  若手研究(B)

    岩井俊憲

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    本研究の目的は患者QOLの向上を目指した低侵襲な内視鏡支援下口腔外科手術を大学病院などの第期の病院だけでなく,小規模な病院や一般開業医にも普及させるために安価な内視鏡システムを開発することである.ノートパソコン上に画像を表示可能である安価な内視鏡システムを開発するため,内視鏡システムの構成は内視鏡本体+USBケーブル+ノートパソコン(Windows)+画像ソフトウェアである.今年度はまず,画像ソフトウェアの開発と内視鏡本体のプロトタイプの開発を行った.内視鏡として,30°や70°の斜視鏡を開発するには内視鏡先端にプリズムを設置する必要がありこの開発には時間を要するため,まずプロトタイプとして0°の内視鏡を作製した.内視鏡はスコープ本体とUSBケーブルでパソコン本体に接続可能とし,ハンドル部で焦点の調整が可能なものとしたスコープはレンズ,イメージガイド,ライトガイド,保護用パイプで構成した.ソフトウェアは動画だけでなく静止画の取り込みと光量調整ができるように開発した.ノートパソコンにソフトウェアをインストールし,実際にUSB接続で内視鏡をノートパソコンに接続し,内視鏡の画質を評価した,画質は比較的良好であったが,内視鏡画像を最新のノートパソコンに映し出すとCPUが45%程度消費した.最新のノートパソコン以外での使用では画像が止まったりすることもあり,今後CPUの消費を減らせるよ...

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  • バーチャルリアリティによる内視鏡支援下口腔外科手術手技訓練システムの開発

    Grant number:21592534  2009 - 2011

    文部科学省  科学研究費補助金  基盤研究(C)

    松井義郎, 藤内祝, 廣田誠, 党健武, 小谷一孔, 岩井俊憲

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    昨年度までに製作した内視鏡支援下顎下腺摘出術訓練システムのプロトタイプを口腔外科医、歯科研修医、医学部学生に対して実際に使用させた後、被験者に対して客観的評価を行い、現状の内視鏡支援下口腔外科手術手技訓練システムの問題点を抽出し、改良を加えてバージョンアップさせプロトタイプとして完成させることを目標とした。客観的評価の結果は、モデル、デバイスの双方において口腔外科経験者よりも臨床未経験者の方が高い満足度を示し、両者の間に統計学的に有意な差を認めた。また、シミュレータ全体の評価においても口腔外科経験者の評価は未経験者に比べて低くなり、経験年数が増えるに従って、満足度が低下する結果となった。よりリアリティを追求するための改善点として、デバイスを増やし両手での操作を可能にすること、顎下腺や血管の位置を自由に決定し、さらに結合組織層を多層化することなどが挙げられた。今回の改良にて、結合組織層の多層化と、2本のペアン鉗子操作の再現が実現したことから、内視鏡支援下口腔外科手術手技訓練システムはプロトタイプとしての完成に至った。今後は、システムの情報量を可能な限り増大させ、出血など様々な条件下でのシミュレートができるように設定する必要がある。また、動物実験を通して、シミュレーションが技術向上の手段として有効であるかどうかの評価を行い、同時に、現在規定値に設定されているデバイスの力覚フィード...

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  • 医工連携に基づく流体解析を用いた超選択的動注法における抗癌剤至適投与量の検討

    Grant number:21390542  2009 - 2011

    文部科学省  科学研究費補助金  基盤研究(B)

    藤内 祝, 光藤健司, 岩井俊憲

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    Grant amount:\17940000 ( Direct Cost: \13800000 、 Indirect Cost:\4140000 )

    口腔癌患者のCT angiography(撮影範囲:眼窩上縁~第6頸椎,スライス幅:0.5mm)のDigital Imaging and COmunication in Medicine (DICOM)データを基に3次元画像処理・編集ソフトウェア(Mimics 14;Materialize Japan)にて,総頸動脈から続く内頸動脈(ICA)と外頸動脈およびその分枝(上甲状腺動脈,舌動脈,顔面動脈,後頭動脈,顎動脈,浅側頭動脈,顔面横動脈および中硬膜動脈)を抽出し,それをSTLファイルとして作製した.さらにMimicsにてSTLの修正を行い,各血管の枝の長さを血管径の5倍の長さ(これまでの基礎研究から得られた必要十分な長さ)としてsurface meshを作製した.次に流体解析プリプロセッサー(ICEM-CFD;ANSYS Japan)にてsurface meshからvolume meshとしてtetra meshとtetra prism meshを作製した.そして,総頸動脈と浅側頭動脈のエコーデータはpatient・specificシミュレーションのために測定したものを用い,これらのデータを用いて流体解析を行うことで,どちらのmeshが本シミュレーションに適切か検討した.Tetra prism meshはtetra mechに比べて計算時間は要するものの,実際に近い血流シミ...

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  • 低侵襲手術としての内視鏡支援下口腔顎顔面外科手術を確立するための内視鏡および手術器具の開発

    2009

    財団法人横浜総合医学振興財団  萌芽的研究助成 

    岩井俊憲

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    Authorship:Principal investigator  Grant type:Competitive

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  • インプラントBANの前臨床評価と電波伝搬に関する研究

    2008 - 2009

    独立行政法人情報通信研究機構(NICT)  委託研究 

    井上登美夫,藤内 祝,岩井俊憲

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    Grant type:Competitive

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  • 口腔顎顔面領域における内視鏡を用いた低侵襲手術の開発および確立

    2008

    内視鏡医学研究振興財団  研究助成(B) 

    岩井俊憲

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    Authorship:Principal investigator  Grant type:Competitive

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  • 下顎におけるナビゲーション支援手術の開発および確立

    2008

    財団法人横浜総合医学振興財団  萌芽的研究助成 

    岩井俊憲

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    Authorship:Principal investigator  Grant type:Competitive

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Other

  • 日本口腔科学会認定医・指導医

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  • 口腔がん専門医・指導医

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  • 日本顎変形症学会認定医(口腔外科)・指導医(口腔外科)

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  • 口腔外科専門医・指導医

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  • 歯科医師臨床研修指導医

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  • 日本口腔診断学会認定医・指導医

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  • がん治療認定医(歯科口腔外科)・指導責任者

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Teaching Experience

  • 口腔外科学(歯牙・顔面外傷,唾液腺・神経疾患)

    Institution:横浜市立大学

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Media Coverage

  • 唾石症とは? Newspaper, magazine

    日本経済新聞  カラダづくり  2023.6

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    Author:Other 

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  • からだの質問箱 内視鏡下唾石摘出術で負担減 Newspaper, magazine

    読売新聞  2023.5

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  • ナゾの病4連発スペシャル 顔が激しく痛む美女の謎 TV or radio program

    日本テレビ  ザ!世界仰天ニュース  インタビュー出演,医療監修  2020.9

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    Author:Myself 

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  • (どうしました)唾石症、唾液腺切除は? Newspaper, magazine

    朝日新聞  2019.7

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    Author:Other 

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  • 唾液の通り道に結石 =カルシウムの塊ー唾石症 Internet

    時事メディカル  治療・予防 医療ニュース  2016.9

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    Author:Other 

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  • 医心伝身 傷が残らないように石を摘出 唾石症における「内視鏡治療」 Newspaper, magazine

    週刊ポスト  2015.9

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    Author:Other 

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  • 先進医療を市民へ 再建術(良好な顎の形を再現) Newspaper, magazine

    神奈川新聞  2015.2

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    Author:Myself 

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  • 未来医療への懸け橋 低侵襲手術(生活の質大きく向上) Newspaper, magazine

    神奈川新聞  2014.4

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    Author:Myself 

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