Updated on 2026/05/28

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写真a

 
Yuka Oi
 
Organization
Yokohama City University Hospital Obstetrics & Gynecology,Women's Health Assistant Professor
Title
Assistant Professor
External link

Research Areas

  • Life Science / Obstetrics and gynecology

Papers

  • Immune Checkpoint Inhibitor-induced Mass-forming Pancreatitis and Lipodystrophy: A Case Report and Review of the Literature.

    Yuka Oi, Takuya Takayanagi, Koki Kakuta, Hitoshi Arioka, Tatsuya Matsunaga

    Internal medicine (Tokyo, Japan)   64 ( 22 )   3238 - 3243   2025.11

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    Mass-forming pancreatitis and lipodystrophy are rare immune-related adverse events (irAEs). A 71-year-old woman received 12 cycles of pembrolizumab for recurrent uterine endometrial cancer. The patient presented with mass-forming pancreatitis and lipodystrophy. A needle biopsy of the pancreatic tissue revealed lymphocytic infiltration and fibrosis. Simultaneously, the patient exhibited lipodystrophy. The recurrent tumors disappeared, so the patient discontinued immune checkpoint inhibitor treatment and was administered oral prednisolone. In addition, the pancreatic mass disappeared; however, the fat loss did not improve. Considering pancreatitis and lipodystrophy to be irAEs, prompt management is important.

    DOI： 10.2169/internalmedicine.5072-24

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  • Treatment Outcomes of Pelvic Organ Prolapse Seven Years After the Introduction of Sacrocolpopexy at a Single Institution. International journal

    Yuka Oi, Tatuya Matsunaga, Sayako Nakagawa, Mihoko Dofutsu, Keiko Segawa, Mai Shimura, Yoshiko Arata, Atsuko Furuno, Kayo Katayama, Osamu Chaki

    Cureus   17 ( 8 )   e89647   2025.8

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    Introduction Pelvic organ prolapse (POP) affects up to 30% of women during their lifetime and significantly impairs quality of life. In Japan, laparoscopic sacrocolpopexy was covered by national insurance starting in 2014 and has become an established treatment option. Objective This study evaluates the long-term outcomes of POP surgery, including recurrence and complications, seven years after the introduction of sacrocolpopexy at our institution. Methods Our institution introduced sacrocolpopexy in 2016, while continuing to perform conventional vaginal surgery. Sacrocolpopexy was primarily offered to patients under 80 years of age without diabetes; for other patients, vaginal surgery was generally chosen. Among vaginal surgeries, patients with a favorable general condition underwent native tissue repair (NTR). We retrospectively reviewed the medical records of patients who underwent sacrocolpopexy or NTR between April 2016 and June 2023. Results During the period, 90 patients underwent POP surgery, with 37 undergoing sacrocolpopexy and 38 receiving NTR; these 75 cases were included in the analysis. In the sacrocolpopexy group, the median time from symptom onset to surgery was 24 months, and 22 patients had used a pessary preoperatively. The median operative time for sacrocolpopexy was 196 minutes, with minimal bleeding and no intraoperative complications. Postoperative adverse events after sacrocolpopexy included one case each of delirium and acute cholecystitis. Recurrence of stage II or higher POP was observed in three patients in the sacrocolpopexy group; two of these had preoperative stage IV disease and had waited 60 months from symptom onset to surgery. In the NTR group, the median time to surgery was 42 months, and 32 patients had used a pessary preoperatively. The median operative time for NTR was 89 minutes, with minimal bleeding and no intraoperative complications. One postoperative complication (vaginal cuff hematoma) was observed after NTR. Recurrence of POP stage II or higher occurred in three NTR patients, all of whom were stage III or higher preoperatively. Conclusion Sacrocolpopexy and NTR are effective surgical options for POP, particularly in patients who do not respond to conservative management. Although sacrocolpopexy and NTR had a low complication and recurrence rate, it is important to bear in mind that recurrence is possible.

    DOI： 10.7759/cureus.89647

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  • 当院の妊娠後骨粗鬆症例に対する後方視的検討

    道佛 美帆子, 大井 由佳, 近藤 晴花, 山口 紗彩, 中川 沙綾子, 宇都宮 真理子, 志村 茉衣, 荒田 与志子, 松永 竜也, 茶木 修

    日本女性医学学会雑誌   32 ( 2 )   337 - 342   2025.1

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    Language：Japanese   Publisher：(一社)日本女性医学学会  

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  • vNOTESによる子宮全摘術の適応決定におけるダグラス窩癒着の術前MRI評価に関して

    鈴木 琴音, 大井 由佳, 雪森 彩花, 上田 波奈, 前田 れな, 荒川 聡美, 石阪 麻莉, 志村 茉衣, 小池 繁臣, 松永 竜也

    日本産科婦人科内視鏡学会雑誌   41 ( 2 )   27 - 32   2025

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  • 当院の全腹腔鏡下子宮全摘術後の追跡期間と退院後の合併症に関する検討

    志村 茉衣, 大井 由佳, 山口 笑里, 山口 紗彩, 宇都宮 真理子, 道佛 美帆子, 瀬川 恵子, 松永 竜也

    日本産科婦人科内視鏡学会雑誌   41 ( 2 )   10 - 13   2025

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  • 本症例を含めた本邦でのリスク因子を伴わない嵌頓子宮妊娠5症例の妊娠分娩管理についての検討

    山口 笑里, 志村 茉衣, 山口 紗彩, 宇都宮 真理子, 道佛 美帆子, 瀬川 恵子, 大井 由佳, 茶木 修, 松永 竜也

    関東連合産科婦人科学会誌   61 ( 1 )   71 - 75   2024.3

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    Language：Japanese   Publisher：(一社)関東連合産科婦人科学会  

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  • SDGsの時代を見据えた腹腔鏡手術における医療廃棄物削減の試み

    志村 茉衣, 大井 由佳, 山口 笑里, 山口 紗彩, 宇都宮 真理子, 道佛 美帆子, 瀬川 恵子, 松永 竜也

    日本産科婦人科内視鏡学会雑誌   40 ( 1 )   60 - 63   2024

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  • 腹腔鏡手術において、退院時の診察を主治医が実施することで退院後の合併症は減少するか

    山口 笑里, 大井 由佳, 山口 紗彩, 宇都宮 真理子, 道佛 美帆子, 志村 茉衣, 瀬川 恵子, 松永 竜也

    日本産科婦人科内視鏡学会雑誌   40 ( 2 )   16 - 20   2024

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  • TLHにおける術後腹腔内ドレーン留置省略の試み

    佐藤 理穂, 大井 由佳, 相原 隆充, 宇都宮 真理子, 道佛 美帆子, 瀬川 恵子, 笠井 絢子, 松永 竜也

    日本産科婦人科内視鏡学会雑誌   38 ( 2 )   48 - 52   2022

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  • 腹腔鏡下子宮悪性腫瘍手術に対する患者の意識調査

    平田 豪, 戸田 美咲, 木野 民奈, 堀田 裕一朗, 小河原 由貴, 若林 玲南, 石寺 由美, 大井 由佳, 片山 佳代, 茂田 博行, 吉田 浩

    神奈川産科婦人科学会誌   58 ( 1 )   80 - 84   2021.9

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    Language：Japanese   Publisher：神奈川産科婦人科学会  

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  • 重複子宮に対する腹腔鏡下単純子宮全摘術の経験

    窪田 葵, 大井 由佳, 佐野 泰子, 橋本 彩紗, 北島 麻衣子, 小林 奈津子, 瀬川 恵子, 笠井 絢子, 茶木 修, 中山 昌樹

    関東連合産科婦人科学会誌   57 ( 4 )   445 - 449   2020.11

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  • Does the extension of the type of hysterectomy contribute to the local control of endometrial cancer?

    Tetsuya Hasegawa, Megumi Furugori, Kazumi Kubota, Mikiko Asai-Sato, Aiko Yashiro-Kawano, Hisamori Kato, Yuka Oi, Hiroyuki Shigeta, Keiko Segawa, Masakazu Kitagawa, Yuko Mine, Haruya Saji, Reiko Numazaki, Yasuyo Maruyama, Emi Ohnuma, Hanako Taniguchi, Ken Sugiura, Etsuko Miyagi, Tatsuya Matsunaga

    International journal of clinical oncology   24 ( 9 )   1129 - 1136   2019.9

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    OBJECTIVE: To examine the necessity and sufficiency of different types of hysterectomy for the surgical treatment of endometrial cancer. METHODS: This was a multicenter collaborative study conducted by 11 institutions. Among patients with stage I-III endometrial cancer who underwent surgery as the initial treatment (only chemotherapy was provided if adjuvant therapy was needed) from 2001 to 2012, we retrospectively examined the type of hysterectomy, clinicopathological factors, recurrence rate over a maximum period of 5 years, and the site of recurrence. The local recurrence rate was examined by univariate and multivariate analyses. RESULTS: Among 1335 patients, 982 (73.6%) underwent simple hysterectomy (SH) and 353 (26.4%) underwent modified radical hysterectomy (mRH) and were observed for a mean duration of 51.8 months. No significant difference was observed in the rate of local recurrence between the SH and mRH groups (p = 0.928). In multivariate analysis, clinicopathological factors independently associated with localized recurrence included postmenopausal status [hazard ratio (HR) 5.036, 95% confidence interval (CI) 1.506-16.841, p = 0.009], with stages II (HR 3.337, 95% CI 1.701-6.547, p < 0.001) and III (HR 2.445, 95% CI 1.280-4.668, p = 0.007), vs stage I and histological type 2 (HR 1.610, 95% CI 0.938-2.762, p = 0.001). CONCLUSIONS: For endometrial cancer patients requiring surgery, the selection of a more extensive type of hysterectomy did not reduce the rate of local recurrence. Therefore, there is little significance in performing mRH in such cases.

    DOI： 10.1007/s10147-019-01458-2

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  • Analysis of uterine corporeal mesenchymal tumors occurring after menopause. International journal

    Yumi Ishidera, Hiroshi Yoshida, Yuka Oi, Kayo Katayama, Etsuko Miyagi, Hiroyuki Hayashi, Hiroyuki Shigeta

    BMC women's health   19 ( 1 )   13 - 13   2019.1

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    OBJECTIVE: Because it is difficult to diagnose accurately whether uterine corporeal mesenchymal tumors are benign or malignant before surgery, an understanding of the characteristics of patients with uterine sarcomas occurring in the postmenopausal period is required. METHODS: We retrospectively reviewed the cases of women who underwent surgery for uterine mesenchymal tumors at our hospital. RESULTS: Among 487 operated cases, 447 tumors occurred in the premenopausal period and 40 occurred in the postmenopausal period. Uterine sarcomas were observed in 5 cases (1.1%) during the premenopausal period and in 11 cases (28%) during the postmenopausal period. Among the postmenopausal patients, age, age at menopause, body mass index (BMI), tumor size, incidence of abnormal vaginal bleeding, serum tumor marker levels (cancer antigen 125, carbohydrate antigen 19-9, and carcinoembryonic antigen), and serum lactate dehydrogenase values were not significantly different between patients with benign tumors and those with malignant tumors. On the other hand, the incidence to have abnormal signal on MRI was significantly higher in patients with malignant tumors than in patients with benign tumors. CONCLUSION: In our hospital, the incidence of malignant tumors in women with uterine corporeal mesenchymal tumors was much higher in postmenopausal patients than in premenopausal patients. Because it is generally not easy to diagnose uterine sarcomas before surgery, surgery should be positively considered when uterine sarcomas cannot be ruled out for patients in the postmenopausal period.

    DOI： 10.1186/s12905-019-0714-5

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  • A case of uterine carcinosarcoma which was strongly suspected to have metastases to the psoas and gluteus muscles. International journal

    Yumi Ishidera, Hiroshi Yoshida, Yuka Oi, Kayo Katayama, Noriko Ando, Hiroyuki Shigeta

    International cancer conference journal   7 ( 4 )   121 - 124   2018.10

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    Metastasis to the skeletal muscles is uncommon. We report a case which was strongly suspected to have psoas and gluteus muscle metastases from uterine carcinosarcoma. A 68-year-old woman (gravida, 2; para, 0) underwent retroperitoneal endoscopic paraaortic lymphadenectomy, laparoscopic modified radical hysterectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy for uterine carcinosarcoma, suspected to be stage IB. Metastasis to one right pelvic lymph node was observed. Ascites fluid cytology was negative. Postoperative pathological examination revealed stage IIIC1 (pT1bN1M0) disease. Five cycles of chemotherapy with paclitaxel + carboplatin were performed. 10 months after chemotherapy, serum cancer antigen-125 level was elevated. Computed tomography (CT) revealed a 3-cm tumor of the left psoas muscle and magnetic resonance imaging revealed a tumor of the left gluteus maximus muscle. These lesions showed fluorodeoxyglucose uptake in positron emission tomography-CT. Because we considered the tumors were metastases of uterine carcinosarcoma, we recommended her chemotherapy. However, after one cycle of chemotherapy, the patient underwent immunotherapy elsewhere with immune checkpoint inhibitors. 5 months after the recurrence, she was alive.

    DOI： 10.1007/s13691-018-0333-2

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  • Significance of postmenopausal uterine leiomyomas: Focus on variants. International journal

    Yuka Oi, Kayo Katayama, Go Hirata, Yumi Ishidera, Hiroshi Yoshida, Hiroyuki Shigeta

    The journal of obstetrics and gynaecology research   44 ( 8 )   1445 - 1450   2018.8

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    AIM: To investigate the differences in leiomyoma pathophysiology by patient age at the time of surgery and the possible significance of postmenopausal uterine leiomyomas, particularly variants. METHODS: We retrospectively reviewed data from 471 patients who underwent surgery for uterine leiomyomas and evaluated their clinical data. RESULTS: Overall, 441 (93.4%) women were premenopausal and 30 (6.4%) were postmenopausal. There were no differences in the frequency of the coexistence of ovarian steroid-dependent diseases among age groups. Common histopathological features were observed in most cases despite menopausal status; however, the incidence of variants among postmenopausal patients was high compared to that among premenopausal women (23.3% [7/30] vs 3.2% [14/441], respectively). Among the variant leiomyomas in postmenopausal patients, lipoleiomyomas comprised six. CONCLUSION: Although progesterone is known to play a vital role in promoting leiomyoma growth, it reportedly performs dual actions and does not always stimulate leiomyoma growth. Our study may support the idea that the dual action of progesterone is the primary reason for the surgical treatment required for uterine leiomyomas in the postmenopausal period. We also found that lipoleiomyoma might be the most common uterine leiomyoma variant requiring surgical treatment among postmenopausal women. Thus, we must consider the diagnosis of uterine lipoleiomyoma in postmenopausal women with uterine leiomyomas.

    DOI： 10.1111/jog.13675

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  • Combined large cell neuroendocrine carcinoma and endometrioid carcinoma of the endometrium: a shared gene mutation signature between the two histological components. International journal

    Masayo Ariura, Rika Kasajima, Yohei Miyagi, Yumi Ishidera, Yoshinobu Sugo, Yuka Oi, Hiroyuki Hayashi, Hiroyuki Shigeta, Etsuko Miyagi

    International cancer conference journal   6 ( 1 )   11 - 15   2017.1

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    A 61-year-old Japanese woman was diagnosed with FIGO Stage IB endometrioid cancer (EC) combined with large cell neuroendocrine carcinoma (LCNEC). Metastasis to the lymph nodes in the right bronchopulmonary area, mediastinum and brain were also identified. The patient eventually developed pleuritis and pericarditis carcinomatosa, and died of cancer at 51 months after surgery. Because gene aberrations in uterine neuroendocrine carcinoma are still not well understood, we examined alterations in the mutational hotspots of 50 selected cancer-associated genes. The EC and LCNEC components shared identical alterations in PTEN, PIK3CA and FGFR3. Both the EC and LCNEC components had heterozygous SBSs on CTNNB1 but at different codons (G34R in EC, and T41A in LCNEC). The altered gene signature raised a possibility that the EC and LCNEC components were derived from a common precursor lesion. The LCNEC independently obtained a significant CTNNB1 mutation and the lymph node metastasis originated from this component. Because the LCNEC component seemed to bring about the aggressive course of the disease and defined the patient outcome, further investigations are needed to elucidate the mechanism of NE carcinoma development in the endometrium.

    DOI： 10.1007/s13691-016-0263-9

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  • Hyperthyroidism due to struma ovarii: Diagnostic pitfalls and preventing thyroid storm. International journal

    Koichi Nagai, Hiroshi Yoshida, Kayo Katayama, Yumi Ishidera, Yuka Oi, Noriko Ando, Hiroyuki Shigeta

    Gynecology and minimally invasive therapy   6 ( 1 )   28 - 30   2017

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    We report struma ovarii in a case that had hyperthyroidism and was treated with laparoscopic tumor resection. A 40-year-old Japanese woman presented with tachycardia, finger tremor, and weight loss. Although blood examination showed hyperthyroidism, test results for thyroid stimulating hormone receptor antibody and thyroid stimulating antibody were negative, and thyroid scintigraphy showed no abnormal findings. Because she was diagnosed with an ovarian tumor, and whole-body scintigraphy showed that iodine uptake was detected in the pelvic space, we diagnosed her with an ovarian tumor, which caused excessive thyroid hormone secretion. After controlling the thyroid hormone level, we resected the ovarian tumor laparoscopically. The thyroid hormone level was within the normal range postoperatively without any medications. Based on our experience, physicians need to remember that ovarian tumors can cause hyperthyroidism. Controlling the thyroid hormone level preoperatively by using antithyroid drugs and performing minimally invasive laparoscopic surgery is considered useful for preventing thyroid storm.

    DOI： 10.1016/j.gmit.2016.05.002

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