2026/08/02 更新

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写真a

アベ　コウキ
安部 晃生
Koki Abe
所属
附属病院 整形外科 助教
職名
助教
外部リンク

学位

  • 博士（医学） （ 2022年9月   横浜市立大学 ）

  • 医学士 （ 2017年3月   東海大学 ）

所属学協会

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論文

  • Accuracy of automated segmentation of gluteus and paraspinal muscles in patients with hip osteoarthritis using TotalSegmentator in 3Dslicer. 国際誌

    Hyonmin Choe, Shogo Yokota, Ryohei Iino, Koki Abe, Hironori Yamane, Yuta Hieda, Hiroyuki Ike, Ken Kumagai, Naomi Kobayashi, Yutaka Inaba

    Arthroplasty (London, England)   8 ( 1 )   2026年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1186/s42836-026-00412-8

    Web of Science

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  • Acute asymptomatic pulmonary thromboembolism detected using dynamic digital radiography following total hip arthroplasty: a case report 国際誌

    Yuta Hieda, Kazuma Miyatake, Hyonmin Choe, Koki Abe, Yutaka Inaba

    European Heart Journal - Case Reports   10 ( 6 )   ytag427   2026年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/ehjcr/ytag427

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  • Sterile But Not Clean: Managing Retained PMMA in Autoclaved Surgical Trays

    Koki Abe, Hyonmin Choe, Yutaka Inaba

    Journal of Bone and Joint Surgery   108 ( 9 )   616 - 617   2026年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.2106/JBJS.25.01520

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  • Association between functional combined anteversion and dislocation after revision total hip arthroplasty. 国際誌

    Yuta Hieda, Hyonmin Choe, Koki Abe, Hiroyuki Ike, Masashi Shimoda, Hironori Yamane, Akira Morita, Kosuke Sumi, Ken Kumagai, Naomi Kobayashi, Yutaka Inaba

    Arthroplasty (London, England)   8 ( 1 )   2026年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1186/s42836-026-00383-w

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  • Small increases in patellar thickness significantly alter patellofemoral kinematics and joint loading. 国際誌

    Jobe Shatrov, A Mounir Boudali, Koki Abe, David Parker, Elizabeth Clarke, William L Walter

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA   2026年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/ksa.70282

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  • Factors associated with elevated serum gentamicin levels in hip and knee joints treated with continuous local antibiotic perfusion: A retrospective cohort study.

    Masashi Shimoda, Hyonmin Choe, Yuta Hieda, Koki Abe, Hiroyuki Ike, Hideo Mitsui, Hiroto Kono, Ken Kumagai, Naomi Kobayashi, Yutaka Inaba

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   31 ( 4 )   835 - 840   2026年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Continuous local antibiotic perfusion (CLAP) delivers high-concentration antibiotics locally to achieve the minimal biofilm eradication concentration. Although CLAP has shown efficacy in orthopaedic infections, data on serum gentamicin levels and associated complications remain limited. This study aimed to evaluate serum gentamicin elevation and related adverse events during CLAP, and to identify contributing factors. METHODS: A retrospective review was conducted of 59 patients who underwent CLAP for hip or knee joints between 2019 and 2024, with perioperative serum gentamicin levels measured. Data included laboratory findings, CLAP duration, number of intra-soft tissue perfusion (iSAP) tubes and intra-medullary perfusion (iMAP) pins, gentamicin dose, peak serum gentamicin level, and adverse events. RESULTS: Serum gentamicin levels exceeded 1.0 μg/mL in 21 patients (36 %). The median day of peak serum gentamicin level was 7 postoperative days (IQR, 3-10), most frequently on postoperative day (POD) 3 and POD 10. Acute kidney injury (AKI) occurred in 7 cases (12 %), with one requiring temporary dialysis. Renal function recovered in all cases after cessation of CLAP. No ototoxicity (cranial nerve VIII toxicity) was observed. A univariate analysis showed that a greater number of iMAP pins, longer CLAP duration, higher gentamicin doses, and abnormal preoperative laboratory values (including lower albumin and hemoglobin, and higher CRP, ESR, creatinine, and neutrophil counts) were associated with elevated serum gentamicin levels. CONCLUSION: Elevated serum gentamicin levels occurred in a subset of patients treated with CLAP. Elevated serum gentamicin levels may be associated with both treatment-related factors (iMAP pins, gentamicin dose, and CLAP duration) and host-related factors (lower albumin and hemoglobin, renal function, and systemic inflammation). Considering these risk factors may help adjust dosing strategies and contribute to the safe application of CLAP.

    DOI： 10.1016/j.jos.2026.01.004

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  • FRAX score predicts vertebral compression fractures impairing spinal alignment and hip function after total hip arthroplasty: a retrospective cohort study. 国際誌

    Masashi Shimoda, Hyonmin Choe, Hiroyuki Ike, Hideo Mitsui, Koki Abe, Yuta Hieda, Naomi Kobayashi, Yutaka Inaba

    Arthroplasty (London, England)   7 ( 1 )   63 - 63   2025年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1186/s42836-025-00345-8

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  • Patellar obliquity causes altered patellofemoral biomechanics in total knee replacement: An in vitro study. 国際誌

    Jobe Shatrov, A Mounir Boudali, Koki Abe, David Parker, Elizabeth Clarke, William L Walter

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA   2025年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/ksa.70201

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  • 人工関節周囲感染の治療 Continuous Local Antibiotics Perfusionを併用した人工股関節周囲感染に対する治療戦略

    稗田 裕太, 崔 賢民, 池 裕之, 森田 彰, 山根 裕則, 安部 晃生, 霜田 将之, 稲葉 裕, 小林 直実

    神奈川整形災害外科研究会雑誌   38 ( 2 )   25 - 26   2025年11月

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    記述言語：日本語   出版者・発行元：神奈川整形災害外科研究会  

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  • 【成人股関節疾患の診断と治療】術後合併症への対応 手術部位感染(SSI),人工関節周囲感染 高濃度ゲンタマイシンを用いた持続的局所抗菌薬灌流療法による人工股関節周囲感染の治療成績

    霜田 将之, 崔 賢民, 安部 晃生, 稗田 裕太, 稲葉 裕

    別冊整形外科   1 ( 88 )   162 - 166   2025年10月

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  • Evaluation of the Diagnostic Accuracy of Serum Albumin and Globulin in Pyogenic Spondylitis 国際誌

    Hideo Mitsui, Hyonmin Choe, Masashi Shimoda, Hironori Yamane, Yuta Hieda, Koki Abe, Yohei Ito, Hiroyuki Ike, Ken Kumagai, Naomi Kobayashi, Yutaka Inaba

    Journal of Clinical Medicine   14 ( 17 )   2025年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.3390/jcm14176001

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  • Deep Femoral Artery Identification Using Contrast-Enhanced Computed Tomography Images for the Verification of Vascular Injury Risks in Hip Surgery. 国際誌

    Yuta Hieda, Hyonmin Choe, Hiroyuki Ike, Koki Abe, Masashi Shimoda, Ken Kumagai, Naomi Kobayashi, Yutaka Inaba

    Cureus   17 ( 8 )   e89803   2025年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Iatrogenic deep femoral artery (DFA) injury is a serious complication of hip surgery, often resulting from screw or wire placement in the femur owing to the limited visibility of the DFA and its branches during femoral penetration. We aimed to identify the course and location of DFA perforating branches using an imaging-based approach to improve surgical planning and prevent vascular injury during hip procedures, which has not been thoroughly evaluated in prior anatomical studies. We consecutively enrolled 20 female and 20 male participants with unilateral hip osteoarthritis. Contrast-enhanced computed tomography images of the unaffected side were used to identify the DFA. Associations between participant demographics and DFA branch location and trajectory were analyzed. The distance from the apex of the greater trochanter (GTR) to the first DFA perforating branch was significantly shorter in females than in males (mean: 100 (range, 77-122) vs. 113 (range, 99-131) mm, P < 0.001), whereas no significant difference was found for the second branch (mean: 154 (range, 108-242) vs. 160 (range, 128-235) mm, P = 0.73]. The DFA ran within 5 mm of the femur on the medial-posterior aspect at 140 mm and 200 mm distal to the apex of the greater trochanter, typical insertion sites for distal cortical screws in intramedullary nailing for hip fractures. In females, the first DFA perforating branch occurs more proximally than in males, necessitating caution during femoral wiring at this level. These findings help refine anatomical understanding of the DFA course, supporting safer surgical planning for intramedullary fixation. The small sample size (n = 40) is one of the limitations and may affect generalizability.

    DOI： 10.7759/cureus.89803

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  • 股関節および膝関節感染に対するCLAPの血中ゲンタマイシン濃度上昇と合併症発生の検証

    霜田 将之, 崔 賢民, 池 裕之, 安部 晃生, 稗田 裕太, 山根 裕則, 稲葉 裕

    東日本整形災害外科学会雑誌   37 ( 3 )   221 - 221   2025年8月

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    記述言語：日本語   出版者・発行元：東日本整形災害外科学会  

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  • Clinical outcomes of continuous local antibiotic perfusion in combination with debridement antibiotics and implant retention for periprosthetic hip joint infection. 国際誌

    Yuta Hieda, Hyonmin Choe, Akihiro Maruo, Koki Abe, Masashi Shimoda, Hiroyuki Ike, Ken Kumagai, Naomi Kobayashi, Yutaka Inaba

    Scientific reports   15 ( 1 )   26017 - 26017   2025年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41598-025-11808-y

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  • 2836検体の骨・軟部組織感染症に対するPCR診断の解析結果

    稗田 裕太, 崔 賢民, 霜田 将之, 安部 晃生, 石川 喜美, 池 裕之, 山根 裕則, 友山 瑛人, 小林 直実, 稲葉 裕

    日本骨・関節感染症学会プログラム・抄録集   48回   70 - 70   2025年7月

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    記述言語：日本語   出版者・発行元：(一社)日本骨・関節感染症学会  

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  • 人工関節周囲感染(PJI)および手術部位感染(SSI)症例における最小バイオフィルム破壊濃度(MBEC)と最小発育阻止濃度(MIC)の比較検討

    友山 瑛人, 崔 賢民, 石川 喜美, 安部 晃生, 稗田 裕太, 霜田 将之, 稲葉 裕

    日本骨・関節感染症学会プログラム・抄録集   48回   48 - 48   2025年7月

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    記述言語：日本語   出版者・発行元：(一社)日本骨・関節感染症学会  

    J-GLOBAL

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  • 吸収性局所止血剤サージセルパウダーの殺菌効果および骨芽細胞への影響

    霜田 将之, 崔 賢民, 石川 喜美, 友山 瑛人, 池 裕之, 三井 英央, 安部 晃生, 稗田 裕太, 稲葉 裕

    日本骨・関節感染症学会プログラム・抄録集   48回   64 - 64   2025年7月

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    記述言語：日本語   出版者・発行元：(一社)日本骨・関節感染症学会  

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  • チタンプレートを用いたラット大腿骨における術後インプラント感染モデル

    霜田 将之, 崔 賢民, 石川 喜美, 友山 瑛人, 安部 晃生, 稗田 裕太, 河野 寛人, 稲葉 裕

    日本骨・関節感染症学会プログラム・抄録集   48回   63 - 63   2025年7月

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    記述言語：日本語   出版者・発行元：(一社)日本骨・関節感染症学会  

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  • 骨・軟部組織感染症に対するPCR遺伝子診断の検討 2836検体における組織・部位・菌株ごとの比較

    稗田 裕太, 崔 賢民, 霜田 将之, 安部 晃生, 池 裕之, 勝山 陽太, 山根 裕則, 三井 英央, 小林 直実, 稲葉 裕

    日本整形外科学会雑誌   99 ( 2 )   S455 - S455   2025年3月

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    記述言語：日本語   出版者・発行元：(公社)日本整形外科学会  

    J-GLOBAL

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  • 大腿骨近位部骨折におけるvirtual髄内釘を用いた大腿骨頭内骨質量の測定

    榎本 大介, 松本 匡洋, 崔 賢民, 安部 晃生, 稲葉 裕

    神奈川医学会雑誌   52 ( 1 )   53 - 54   2025年1月

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    記述言語：日本語   出版者・発行元：(公社)神奈川県医師会  

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  • CT-Based Evaluation of Bone Mineral Density Distribution of Proximal Femur in Patients With Femoral Trochanteric Fracture. 国際誌

    Daisuke Enomoto, Hyonmin Choe, Masahiro Matsumoto, Koki Abe, Kazuyoshi Yamamoto, Kousuke Matsuo, Hiroyuki Makita, Naomi Kobayashi, Yutaka Inaba

    Geriatric orthopaedic surgery & rehabilitation   16   21514593251361803 - 21514593251361803   2025年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1177/21514593251361803

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  • A novel in vitro experimental design for biomechanical testing of patellofemoral joint kinetics and kinematics 国際誌

    A. Mounir Boudali, Jobe Shatrov, Koki Abe, Marcus Zavala, David Parker, William L. Walter, Elizabeth Clarke

    SICOT-J   11   49 - 49   2025年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1051/sicotj/2025043

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  • Muscle Atrophy Around the Hip Joint in Patients with Femoral Neck Fracture is Associated with Postoperative Walking Ability. 国際誌

    Hyonmin Choe, Takahiro Yoneda, Masatoshi Oba, Koki Abe, Hiroyuki Ike, Ken Kumagai, Naomi Kobayashi, Yutaka Inaba

    Geriatric orthopaedic surgery & rehabilitation   16   21514593251336626 - 21514593251336626   2025年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1177/21514593251336626

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  • Bead-beating assay during synovial fluid DNA extraction improves real-time PCR accuracy for periprosthetic joint infection. 国際誌

    Yuta Hieda, Hyonmin Choe, Hiroyuki Ike, Koki Abe, Ken Kumagai, Masanobu Takeyama, Yusuke Kawabata, Naomi Kobayashi, Yutaka Inaba

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society   42 ( 10 )   2123 - 2130   2024年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Polymerase chain reaction (PCR)-based genetic diagnosis is a rapid and sensitive method to diagnose periprosthetic joint infection (PJI). DNA extraction using bead beating is an effective method for collecting bacterial genes in Gram-positive bacteria. We compared the detection accuracy between the conventional and bead-beating DNA extraction assay. The detection rate improved from 86.7% using the conventional method to 95.6% using the bead-beating. Our results suggest that bead-beating during DNA extraction can improve the accuracy of PCR-based genetic diagnosis of PJI.

    DOI： 10.1002/jor.25871

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  • Accuracy of Albumin, Globulin, and Albumin-Globulin Ratio for Diagnosing Periprosthetic Joint Infection: A Systematic Review and Meta-Analysis. 国際誌

    Hyonmin Choe, Emi Kamono, Koki Abe, Yuta Hieda, Hiroyuki Ike, Ken Kumagai, Naomi Kobayashi, Yutaka Inaba

    Journal of clinical medicine   12 ( 24 )   2023年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Periprosthetic joint infection (PJI) is one of the most intractable orthopedic diseases, partly because of the difficulty in differentiating septic from aseptic conditions. We aimed to evaluate and consolidate the diagnostic accuracy of the quantitative assessment of serum albumin (Alb), globulin (Glb), and albumin-globulin ratio (AGR), alone or in combination with the inflammatory marker, C-reactive protein (CRP), for PJI. We searched the PubMed, CINAHL, and Cochrane Library databases for studies that quantitatively measured Alb, Glb, or AGR for the diagnosis of PJI up until the 30 April 2023. A total of 2339 patients were included from 10 studies, including 845 patients with a definitive diagnosis of PJI and 1494 with non-PJI. The pooled sensitivity, specificity, and area under the curve (AUC) in the summary receiver-operating characteristic curve were as follows: 0.625, 0.732, and 0.715 for Alb; 0.815, 0.857, and 0.887 for Glb; 0.753, 0.757, and 0.875 for AGR; 0.788, 0.837, and 0.876 for CRP; 0.879, 0.890, and 0.917 for the CRP-Alb ratio; and 0.845, 0.855, and 0.908 for the CRP-AGR ratio. Serum Alb, Glb, and AGR levels are feasible and accurate diagnostic markers for PJI, and the combination of these markers with CRP levels may potentially improve preoperative serum diagnostic accuracy. Future prospective studies are required to verify these findings because of the small numbers of included studies.

    DOI： 10.3390/jcm12247512

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  • Novel Local Antifungal Treatment for Fungal Periprosthetic Joint Infection With Continuous Local Antibiotic Perfusion: A Surgical Technique. 国際誌

    Hyonmin Choe, Akihiro Maruo, Yuta Hieda, Koki Abe, Naomi Kobayashi, Hiroyuki Ike, Ken Kumagai, Masanobu Takeyama, Yusuke Kawabata, Yutaka Inaba

    Arthroplasty today   24   101245 - 101245   2023年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Fungal periprosthetic joint infections are one of the most intractable orthopedic disorders. Continuous local antibiotic perfusion allows direct administration of the antifungal agent micafungin into the local infection area at biofilm-disruptive concentrations, while controlling the dead space in addition to conventional treatment. Although the appropriate use of continuous local antibiotic perfusion requires familiarity with the characteristics of local antibiotic perfusion, it is a versatile treatment modality that can improve the clinical outcomes of fungal periprosthetic joint infection in combination with conventional treatment methods.

    DOI： 10.1016/j.artd.2023.101245

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  • 学会を聞く 第46回日本骨･関節感染症学会

    安部 晃生

    整形外科   74 ( 12 )   1335 - 1338   2023年11月

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    記述言語：日本語   出版者・発行元：南江堂  

    DOI： 10.15106/j_seikei74_1335

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    その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I033131295

  • 連載 最新原著レビュー 急速な股関節破壊例における炎症および栄養評価に基づく感染のスクリーニング検査

    安部 晃生

    整形外科   74 ( 11 )   1209 - 1213   2023年10月

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  • 連載 最新原著レビュー 血清アルブミン･グロブリンとC反応性蛋白の併用は低炎症性人工関節周囲感染に対する血清学的な診断精度を向上する

    崔 賢民, 小林 直実, 安部 晃生, 稗田 裕太, 手塚 太郎, 稲葉 裕

    整形外科   74 ( 10 )   1128 - 1134   2023年9月

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  • Targeting of Periprosthetic Muscles for the Ultrasonographic Screening of Hip Abnormalities in Hip Resurfacing Arthroplasty Patients. 国際誌

    Hyonmin Choe, Naomi Kobayashi, Koki Abe, Yuta Hieda, Hiroyuki Ike, Ken Kumagai, Kazuma Miyatake, Takahiro Fujisawa, Yutaka Inaba

    Journal of clinical medicine   12 ( 8 )   2023年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Hip resurfacing arthroplasty (HRA) patients require subsequent annual screening for postoperative complications. Ultrasonography may be useful for this purpose but lacks a screening protocol for hips. The purpose of this study was to evaluate the accuracy of ultrasonography for detecting postoperative complications in HRA patients using a screening protocol that specifically targets periprosthetic muscles. METHODS: We enrolled 45 hips from 40 HRA patients with a mean follow-up period of 8.2 years. MRI and ultrasonography scans were simultaneously conducted at follow-up. The ultrasonography assessments were conducted on the anterior part of the hip that targets iliopsoas, sartorius, rectus femoris, lateral with anterior superior and inferior iliac spine (ASIS and AIIS) as bony landmarks, and the lateral and posterior parts that target fascia tensor, short rotators, and gluteus minimus, medius, and maximus with greater trochanter and ischial tuberosity as bony landmarks. The accuracy of diagnosing postoperative abnormalities and the visibility of periprosthetic muscles were compared between these two modalities. RESULTS: Both MRI and ultrasonography detected an abnormal region in eight cases comprising two infections, two pseudotumors, and four patients with greater trochanteric bursitis. Among these cases, four hips required implant removal. The increase in anterior space, measured as the distance between the iliopsoas and resurfacing head, was a good indicator for the abnormal mass in these four HRA cases. In the assessment of periprosthetic muscles, MRI showed a much lower visibility than ultrasonography in the iliopsoas (6.7% vs. 100%), gluteus minimus (6.7% vs. 88.9%), and short rotators (8.8% vs. 71.4%) due to implant halation. CONCLUSIONS: By targeting periprosthetic muscles, ultrasonography can detect postoperative complications as effectively as MRI assessments in HRA patients. Ultrasonography has superior visibility in the periprosthetic muscles of HRA patients, indicating its utility for the screening of small legions in these cases which may not be visible by MRI.

    DOI： 10.3390/jcm12082871

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  • Corrective osteotomy for complex tibial deformity in a patient with hereditary vitamin D-resistant hypophosphatemic rickets (HVDRR) using CT-based navigation system and 3D printed osteotomy model. 国際誌

    Masatoshi Oba, Hyonmin Choe, Shunsuke Yamada, Yuto Gondai, Koki Abe, Taro Tezuka, Hiroyuki Ike, Yutaka Inaba

    Computer assisted surgery (Abingdon, England)   27 ( 1 )   84 - 90   2022年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Planning a three-dimensional (3D) osteotomy using computed tomography (CT) data is useful especially in cases with complex deformities. Furthermore, CT-based navigation system allows the preoperative virtual planning to be replicated in actual surgery. However, one disadvantage when using navigation systems is that when osteotomies are performed on tracker-attached bone, the bone fragments on the side that were cut away cannot be tracked. This is especially problematic when performing multiple osteotomies on bones with complex deformities. We solved this problem by creating a 3D printed bone model that can be referenced intraoperatively and used in combination with the navigation system. We applied these techniques to perform segmental corrective osteotomy for a complex tibial deformity with intramedullary nail (IMN) fixation case of hereditary vitamin D-resistant hypophosphatemic rickets (HVDRR) in an adult man. Due to the patient's history of multiple surgeries, the affected tibia had a narrow and partially closed medullary canal. Therefore, we planned to use an IMN for correction and fixation of tibial deformity to protect the thin and stretched skin around the deformed tibia. With the assistance of CT-based navigation, we could perform an accurate three-dimensional tibial osteotomy. Moreover, we could perform accurate preparation of closed medullary canal for the IMN placement by referring to the 3D printed bone models. Six months after the operation, the bone union at the osteotomy sites was confirmed and the patient was able to return to his normal life and work.

    DOI： 10.1080/24699322.2022.2086485

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  • Evaluation of Serum Albumin and Globulin in Combination with C-Reactive Protein Improves Serum Diagnostic Accuracy for Low-Grade Periprosthetic Joint Infection. 国際誌

    Hyonmin Choe, Naomi Kobayashi, Koki Abe, Yuta Hieda, Taro Tezuka, Yutaka Inaba

    The Journal of arthroplasty   38 ( 3 )   555 - 561   2022年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Serum immune markers can be useful in the diagnosis of periprosthetic joint infection (PJI) by detecting long-lasting abnormal immunological conditions. The purpose of this study was to examine whether serum immune markers can improve the diagnostic accuracy of PJI. METHODS: We enrolled 51 PJI, 45 aseptic loosening, and 334 osteoarthritis patients for assessment of the discriminatory accuracy of serum markers including white blood cell count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and D-dimer, total protein, albumin (Alb), globulin (Glb), neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, albumin-globulin ratio (AGR), CRP-albumin ratio (CAR), and CRP-AGR ratio (CAGR). These diagnostic accuracies for low-grade PJI were also calculated in patients who had serum CRP levels <10 mg/L. RESULTS: Among serum markers, Alb, Glb, AGR, CRP, ESR, CAR, and CAGR had highly accurate diagnostic accuracy for PJI, with AUC of 0.92, 0.90, 0.96, 0.97, 0.92, 0.97, and 0.98, respectively. In low-grade PJI patients, AUC of CRP, ESR, CAR, and CAGR (0.69, 0.80, 0.65, and 0.82, respectively) was decreased, but that of Alb, Glb, and AGR (0.90, 0.88, 0.95, respectively) remained high, indicating the diagnostic utility of these immune markers. The sensitivity and specificity of AGR with cutoff value of 1.1 were demonstrated as 0.92 and 0.89, respectively, and with cutoff value of 1.2, 1.00 and 0.79, respectively, in the diagnosis of low-grade infection. CONCLUSION: Our results demonstrate the potential value of Alb, Glb, AGR, and combination indices of these immune makers with CRP in improving preoperative serum diagnosis for PJI, especially in low-grade PJI.

    DOI： 10.1016/j.arth.2022.09.011

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  • Bilateral fragility femoral supracondylar fractures in adolescents due to long-term home stay during the COVID-19 pandemic: A case report.

    Hyonmin Choe, Naomi Kobayashi, Masatoshi Oba, Taro Tezuka, Hiroyuki Ike, Akira Morita, Koki Abe, Yutaka Inaba

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   29 ( 1 )   405 - 408   2022年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.jos.2022.05.014

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  • Inflammation and nutrition based screening tests for detection of infection in cases of rapid hip destruction. 国際誌

    Koki Abe, Hyonmin Choe, Masatoshi Oba, Taro Tezuka, Hiroyuki Ike, Naomi Kobayashi, Yutaka Inaba

    Scientific reports   12 ( 1 )   3586 - 3586   2022年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Preoperative diagnosis of infection is important for appropriate surgical treatment of patients with rapid hip destruction (RHD). We investigated whether test results, including inflammatory and nutritional markers, could be used to accurately differentiate infectious and non-infectious RHD. Fifty patients with RHD who underwent total hip arthroplasty within a year of onset were observed. Infectious RHD was defined as ≥ 2 positive serological inflammatory, microbiological, or pathological evaluations. The albumin to globulin ratio (AGR), C-reactive protein (CRP)/albumin ratio (CAR), Glasgow prognostic score (GPS), modified GPS (mGPS), prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI), and platelet to lymphocyte ratio (PLR) were calculated from the blood test results. In the infectious group, the white blood cell count, platelet count, CRP level, erythrocyte sedimentation rate, CAR, GPS, mGPS, and PLR were significantly higher, while the albumin level, AGR, PNI, and GNRI were significantly lower. The CRP and albumin levels showed the highest sensitivity (1.00 for both; specificity of 0.87 and 0.73, respectively) in diagnosing infectious RHD. Combining these measurements (CAR) increased the specificity to 0.92. The accuracy of other nutritional assessments was good. Thus, nutritional assessment as well as conventional assessment of the inflammatory response can improve the accuracy of preoperative diagnosis of infectious RHD.

    DOI： 10.1038/s41598-022-07678-3

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  • Accuracy of Computer Navigation-Assisted Arthroscopic Osteochondroplasty for Cam-Type Femoroacetabular Impingement Using the Model-to-Image Registration Method. 国際誌

    Koki Abe, Masatoshi Oba, Naomi Kobayashi, Shota Higashihira, Hyonmin Choe, Taro Tezuka, Hiroyuki Ike, Yutaka Inaba

    The American journal of sports medicine   50 ( 5 )   3635465221074338 - 3635465221074338   2022年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Precise osteochondroplasty is important in arthroscopic hip surgery for cam-type femoroacetabular impingement (FAI). Although computer-assisted surgery with a navigation system may enhance the accuracy of arthroscopic osteochondroplasty, few clinical studies have assessed its accuracy. PURPOSE: To evaluate the accuracy of arthroscopic osteochondroplasty by a computed tomography (CT)-based navigation system for cam-type FAI, using 3-dimensional (3D) reconstruction with more detail compared with previous methods. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Twenty patients (14 men and 6 women) who underwent navigation-assisted arthroscopic surgery for cam-type FAI were included. The preoperative 3D model of the femur was constructed from each patient's CT data, and a planned model with virtual cam resection was generated. A femoral model was reconstructed from CT data postoperatively. The 3 models for each patient were overlaid using a 3D model registration method. Then, the contours of the bone resection area of each model were compared by measuring them. To measure the deviation between planned and actual bone resections, 4 cross-sectional images of the 3 femoral models were set at one-quarter intervals from the femoral head radius. All measurements were based on clockface lines set around the femoral neck axis at 30-minute intervals. Differences between the planned and postoperative contour lines were deemed resection deviations. RESULTS: All cam resections were performed in the anterior half of the region of interest. Therefore, only the anterior half (48 points) of the 96 points per case were analyzed. In 876 (91.3%) points of the total measurement points (960 points/20 cases), the error in resection depth was within 3 mm. Overresection was observed at 35 (3.6%) points and underresection at 49 (5.1%) points. The observed maximum deviations from the planned models were 6.3 mm overresection and -7.1 mm underresection. The alpha angles of the postoperative model at the posterior 9- to 3-o'clock position were <55° in all patients. CONCLUSION: Navigation-assisted arthroscopic osteochondroplasty showed favorable accuracy. Underresection was more frequent than overresection on the anterosuperior side of the femur, despite assistance of the navigation system.

    DOI： 10.1177/03635465221074338

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  • Application of Ultrasonography During Sternocleidomastoid Muscle Release for Congenital Muscular Torticollis: A Case Report. 国際誌

    Hyonmin Choe, Naomi Kobayashi, Masatoshi Oba, Akira Morita, Koki Abe, Yutaka Inaba

    JBJS case connector   11 ( 4 )   2021年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    CASE: We report a 4-year-old girl with congenital muscular torticollis (CMT) who was treated with sternocleidomastoid muscle (SCM) tenotomy using ultrasonography (US). Prior to the surgery, US was utilized to identify the clavicle and sternum branches of the SCM, sternohyoid muscles, internal jugular vein, and common carotid artery. Then, local anesthesia was injected into the layer between the fascial sheath of the SCM and carotid sheath to reduce bleeding and avoid vascular injury. During surgery, the SCM dissection was carefully conducted under US guidance to avoid vascular injury. No residual of SCM dissection and improvement of neck motion were confirmed before the skin closure. Postoperative course was good with no obvious complications in this patient. CONCLUSION: The intraoperative US investigation during SCM tenotomy is a useful procedure that provides vital information about dissection area of SCM and orientation of internal jugular vein that reduces the risk of insufficient tenotomy and vascular injury.

    DOI： 10.2106/JBJS.CC.21.00309

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  • Postoperative excessive external femoral rotation in revision total hip arthroplasty is associated with muscle weakness in iliopsoas and gluteus medius and risk for hip dislocation. 国際誌

    Hyonmin Choe, Naomi Kobayashi, Daigo Kobayashi, Shintaro Watanabe, Koki Abe, Taro Tezuka, Yusuke Kawabata, Masanobu Takeyama, Yutaka Inaba

    Journal of orthopaedic surgery and research   16 ( 1 )   582 - 582   2021年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Excessive external femoral rotation (FR) can functionally increase stem anteversion (SA) and is often observed at an early stage after surgery in revision total hip arthroplasty (THA). This study was conducted to investigate the prevalence of external FR, identify the factors associated with external FR, and determine the association of FR and other factors with hip dislocation in revision THA. METHODS: We enrolled 51 revision THA patients (55 hip cases). The patient background, angle of anatomical and functional SA, FR angle, sizes and densities of muscles around the hip joint, impingement distance, and consequence of postoperative hip dislocation were assessed by reviewing their medical history and imaging data that includes computed tomography (CT) scans before and after surgery. RESULTS: Forty-five hip cases (81.8%) showed external FR (mean 13.0°). External FR was significantly correlated with anatomical SA (r =  - 0.54) and increase in functional SA (r = 0.36), which was significantly correlated with impingement distance (r = 0.46). The independent factors associated with external FR in multivariate analysis were the anatomical SA, CT densities of the psoas, gluteus medius and maximus muscles, and 2-stage revision (R2 = 0.559). During follow-up period, eight cases of revision THA showed hip dislocation. FR, functional SA, impingement distance, CT density of psoas and gluteus medius muscle, body mass index, number of past operation, and ratio of 2-stage revision THA were significantly different between cases with dislocation and non-dislocation. The odds ratio of FR and impingement distance for hip dislocation was identified as 1.061(95% confidence interval (CI): 1.011-1.114) and 0.901 (95% CI 0.820-0.991), respectively. CONCLUSIONS: Revision THA frequently causes an external FR that functionally increases the SA and impingement risk, particularly in hips with 2-stage revision with psoas and gluteus medius muscle atrophy. Patients who have undergone revision THA and have an excessive external FR may require careful monitoring for possible hip dislocation due to hip joint instability and impingement.

    DOI： 10.1186/s13018-021-02744-4

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  • 急速な股関節破壊を認める症例で感染性疾患の術前鑑別診断は可能か?

    安部 晃生, 崔 賢民, 池 裕之, 大庭 真俊, 手塚 太郎, 稲葉 裕

    東日本整形災害外科学会雑誌   33 ( 1 )   28 - 32   2021年3月

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    記述言語：日本語   出版者・発行元：東日本整形災害外科学会  

    股関節破壊症例の治療は，人工股関節全置換術を施行することが多く，原因となる疾患が感染性であるかの術前診断が重要である．本研究の目的は，急速な股関節破壊症例において術前の感染診断が可能かについて調査することである．急速な股関節破壊を認めた47症例において，血液中のアルブミン，CRP値，MRI検査による軟部組織への炎症波及の判定が感染と非感染性の鑑別診断に有用であることが検証された．

    DOI： 10.24645/jejot.33.1_28

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    その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J03098&link_issn=&doc_id=20210421550005&doc_link_id=10.24645%2Fjejot.33.1_28&url=https%3A%2F%2Fdoi.org%2F10.24645%2Fjejot.33.1_28&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

  • An automated real-time PCR assay for synovial fluid improves the preoperative etiological diagnosis of periprosthetic joint infection and septic arthritis. 国際誌

    Fan Yang, Hyonmin Choe, Naomi Kobayashi, Taro Tezuka, Masatoshi Oba, Yushi Miyamae, Akira Morita, Koki Abe, Yutaka Inaba

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society   39 ( 2 )   348 - 355   2021年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

    Synovial fluid is important for the preoperative etiological diagnosis of suspected periprosthetic joint infection (PJI) or septic arthritis (SA). GENECUBE, an automated real-time polymerase chain reaction (PCR) assay, was used to detect bacterial mecA (methicillin resistance) and was compared with microbiological cultures for preoperatively diagnosing PJI and SA in 74 patients suspected of these infections and thus earmarked for surgery. PJI and SA were diagnosed in 21 and 6 cases, respectively, using modified ICM 2018 diagnostic criteria. Microbiological cultures determined methicillin-resistant staphylococcus (MRS) as the causative organism in six samples, which were all positive in the GENECUBE assay. Significantly also, the GENECUBE assay detected six MRS infections in culture-negative but infection-diagnosed patients, and in one inconclusive case, suggesting a higher sensitivity of this assay. Compared with microbiological culture, the sensitivity and specificity of the GENECUBE assay for mecAwas 100% and 92.2%, respectively. However, GENECUBE also produced invalid results in three cases, suggesting possible PCR inhibitors in the synovial fluid samples. We additionally validated the accuracy of pan-bacterial real-time PCR targeting 16S rRNA and other tests. Pan-bacterial real-time PCR was as effective as preoperative bacterial culture testing, although the α-defensin assay had the highest sensitivity at 100%. Hence, fully automated real-time PCR targeting of the bacterial mecA gene improves the etiological diagnosis of PJI and SA by reducing the testing time and lowering the false-positive detection rates. A screening approach for α-defensin followed by bacterial mecA gene testing in synovial fluids is therefore a more efficient method of preoperatively diagnosing PJI and SA.

    DOI： 10.1002/jor.24959

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  • Open source software(OSS)によるvolume registration法を用いた寛骨臼回転骨切り術前後の股関節形態の三次元的画像解析

    大庭 真俊, 崔 賢民, 手塚 太郎, 池 裕之, 宮前 祐之, 森田 彰, 安部 晃生, 稲葉 裕

    Hip Joint   46 ( 1 )   577 - 584   2020年8月

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    記述言語：日本語   出版者・発行元：日本股関節学会  

    2013年4月～2018年3月に寛骨臼形成不全症に対してnavigation支援下寛骨臼回転骨切り術(RAO)を行った女性患者20例(平均年齢38.5歳)を対象に、OSSによるvolume registration法を用いて術前後のCT画像を比較し、三次元的画像解析を行った。放射状再構成断面画像で測定したAcetabular Sector Angle(ASA)を測定平面毎にプロットしたスパイダーチャートからは、術前と比べて術後のASAが大きく、被覆が改善していることが判った。荷重部にあたる9時から3時までの範囲のうち、12時から1時半の位置でのASAは、計画よりも実際の術後寛骨臼で有意に小さく、特に骨頭の上前方にあたる1時および1時半方向では計画と実際の術後ASAの差が大きかった。また、寛骨臼後方よりも前方でASAのデータのばらつきが大きい傾向であった。

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  • 急速な股関節破壊を認める症例で感染性疾患の術前鑑別診断は可能か?

    安部 晃生, 崔 賢民, 池 裕之, 大庭 真俊, 手塚 太郎, 森田 彰, 都竹 伸哉, 吉田 沙織, 稲葉 裕

    東日本整形災害外科学会雑誌   32 ( 3 )   336 - 336   2020年8月

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    記述言語：日本語   出版者・発行元：東日本整形災害外科学会  

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  • 関節液に対する全自動リアルタイムPCRを用いたメチシリン耐性ブドウ球菌感染の術前診断

    崔 賢民, 小林 直実, 池 裕之, 手塚 太郎, 大庭 真俊, 安部 晃生, 都竹 伸哉, 稲葉 裕

    日本整形外科学会雑誌  2021年3月  (公社)日本整形外科学会

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    開催年月日： 2021年3月

    記述言語：日本語  

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  • 整形外科感染の診断における関節液中の細菌DNA検出の有用性

    崔 賢民, 手塚 太郎, 大庭 真俊, 宮前 祐之, 森田 彰, 安部 晃生, 稲葉 裕

    日本整形外科学会雑誌  2020年9月  (公社)日本整形外科学会

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    開催年月日： 2020年9月

    記述言語：日本語  

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  • 人工股関節全置換術患者におけるステム周囲の術後骨密度低下に関連する術前因子の検討

    森田 彰, 小林 直実, 崔 賢民, 手塚 太郎, 大庭 真俊, 宮前 祐之, 東平 翔太, 安部 晃生, 稲葉 裕

    日本整形外科学会雑誌  2020年9月  (公社)日本整形外科学会

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    開催年月日： 2020年9月

    記述言語：日本語  

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  • 3D slicerとNiftyNetで行うプログラミング不要の深層学習による,股関節CTデータの自動3Dセグメンテーション

    大庭 真俊, 崔 賢民, 池 裕之, 手塚 太郎, 宮前 祐之, 森田 彰, 安部 晃生, 稲葉 裕

    日本整形外科学会雑誌  2020年9月  (公社)日本整形外科学会

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    開催年月日： 2020年9月

    記述言語：日本語  

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  • 強直股に対してTHAを施行した3例

    都竹 伸哉, 崔 賢民, 池 裕之, 手塚 太郎, 大庭 真俊, 安部 晃生, 稲葉 裕

    東日本整形災害外科学会雑誌  2020年8月  東日本整形災害外科学会

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    開催年月日： 2020年8月

    記述言語：日本語  

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  • 人工股関節再置換術患者における人工股関節周囲筋が大腿骨の外旋および術後インピンジメントリスクに与える影響

    崔 賢民, 手塚 太郎, 池 裕之, 大庭 真俊, 安部 晃生, 都竹 伸哉, 吉田 沙織, 稲葉 裕

    東日本整形災害外科学会雑誌  2020年8月  東日本整形災害外科学会

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    開催年月日： 2020年8月

    記述言語：日本語  

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  • 関節リウマチに伴う重度の足部外反変形に対し関節固定術を施行した1例

    山田 俊介, 熊谷 研, 長岡 亜紀子, 崔 賢民, 手塚 太郎, 宮前 祐之, 安部 晃生, 荻野 剛弘, 稲葉 裕, 持田 勇一, 針金 健吾, 島崎 貴幸

    日本リウマチ学会総会・学術集会プログラム・抄録集  2020年8月  (一社)日本リウマチ学会

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    開催年月日： 2020年8月

    記述言語：日本語  

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  • 関節リウマチ肘に対するlinked type人工肘関節全置換術の術後成績

    安部 晃生, 手塚 太郎, 熊谷 研, 長岡 亜紀子, 崔 賢民, 宮前 祐之, 山田 俊介, 荻野 剛弘, 稲葉 裕, 持田 勇一, 針金 健吾, 島崎 貴幸

    日本リウマチ学会総会・学術集会プログラム・抄録集  2020年8月  (一社)日本リウマチ学会

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    開催年月日： 2020年8月

    記述言語：日本語  

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  • 関節リウマチによる前足部変形に対するLelievre手術の長期成績

    荻野 剛弘, 手塚 太郎, 熊谷 研, 長岡 亜紀子, 崔 賢民, 山田 俊介, 宮前 祐之, 安部 晃生, 稲葉 裕, 持田 勇一, 針金 健吾, 島崎 貴幸

    日本リウマチ学会総会・学術集会プログラム・抄録集  2020年8月  (一社)日本リウマチ学会

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    開催年月日： 2020年8月

    記述言語：日本語  

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  • MRI findings and serum CRP/Albumin Ratio can Improve the Preoperative Diagnostic Accuracy for SAH in Rapid Destructive Hips with False Negative Microbiological Culture.

    Abe Koki, Choe Hyonmin, Ike Hiroyuki, Tezuka Taro, Oba Masatoshi, Tujiku Shinya, Inaba Yutaka

    Orthopedic Research Society.  2021年2月 

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  • Difference of Serum, imaging, and histopathologial findings between rapidly destractive coxithtis and other hip destructive diseases.

    Abe Koki, Choe Hyonmin, Tezuka Taro, Oba Masatoshi, Miyamae Yushi, Akira Morita, Inaba Yutaka

    Asia Pacific Orthopaedic Association,  2021年4月 

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  • Sports activities after lower extremity arthroplasty and osteotomy.

    Abe Koki, Choe Hyonmin, Ike Hiroyuki, Ogino Takehiro, Masaichi Sotozawa, Tezuka Taro, Inaba Yutaka

    Orthopedic Research Society.  2022年2月 

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  • Identification of causative organisms in Periprosthetic joint infections using the Nanopore sequencer

    Koki Abe, Hyonmin Choe, Yuta Hieda, Naomi Kobayashi, Hiroyuki Ike, Taro Tezuka, Yutaka Inaba

    Orthopedic Research Society.  2023年3月 

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  • Identification Of Methicillin Resistance Genes By Fully Automated Real-time Pcr System In Suspected Cases Of Pji And Ssi.

    Koki Abe, Hyonmin Choe, Yuta Hieda, Masashi Shimoda, Hiroyuki Ike, Naomi Kobayashi, Yutaka Inaba

    Orthopedic Research Society.  2024年2月 

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  • Spinal deformity and spinal stiffness are related to each other

    Koki Abe, Sarah Kenny, Henry Bian, Ameneh Sadeghpour, Matthew Lyons, Michael Dixon, Amir Kalanie, Matthew Alfredson, James Reidy, Bill Walter

    Association New South Wales Branch Annual Scientific Meeting  2024年7月 

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  • Spinal deformity and spinal stiffness are related to each other

    Koki Abe, Sarah Kenny, Henry Bian, Ameneh Sadeghpour, Matthew Lyons, Michael Dixon, Amir Kalanie, Matthew Alfredson, James Reidy, Bill Walter

    Australian Orthopaedic Association Annual Scientific Meeting.  2024年10月 

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  • Who needs 3D planning in preoperative planning for total hip arthroplasty? A study using a custom impingement simulation model.

    Koki Abe, Sarah Kenny, Henry Bian, Ameneh Sadeghpour, Michael Dixon, Amir Kalanie, Matthew Alfredson, James Reidy, Bill Walter

    Asia pacific orthopaedic association congress  2025年4月 

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  • AI-BASED PREDICTION OF PELVIC TILT CHANGE IN THA: VALIDATION AND PILOT APPLICATION USING PAIRED RADIOGRAPHS

    Koki Abe, Sarah Kenny, Henry Bian, Bill Walter

    International Society for Technology in Arthroplasty  2025年9月 

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  • Educational effects of using inertial portable navigation in THA.,

    Koki Abe, Henry Bian, Sarah Kenny, Bill Walter

    International Society for Technology in Arthroplasty.  2025年9月 

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  • AI-Based Prediction of Pelvic Tilt Change in THA: Validation and Pilot Application Using Paired Radiographs.

    Koki Abe, Sarah Kenny, Henry Bian, Bill Walter

    European Hip Society.  2025年10月 

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  • Educational effects of using inertial portable navigation in THA

    Koki Abe, Henry Bian, Sarah Kenny, Bill Walter

    European Hip Society.  2025年10月 

    　詳細を見る

  • Spinal deformity and spinal stiffness are related to each other.,

    Koki Abe, Sarah Kenny, Henry Bian, Bill Walter

    European Hip Society.  2025年10月 

    　詳細を見る

▼全件表示

受賞

  • Case Report Award

    2026年7月   第54回日本関節病学会   Schanz骨切り術後の高度変形症例に対して3D骨モデルおよびCT-based navigationを併用し人工股関節全置換術を実施した症例

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  • Best Paper of the Year

    2022年12月   横浜市立大学整形外科  

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  • Member of the Month(International Resident)

    2022年6月   AAOS：American Academy of Orthopaedic Surgeons  

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  • YCU Student Award

    2022年3月   横浜市立大学  

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  • 学術奨励賞

    2021年9月   東日本整形災害外科学会  

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  • NEXT優秀演題アウォード 最優秀賞

    2020年9月   東日本整形災害外科学会  

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  • 教育委員会賞

    2017年3月   東海大学医学部  

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▼全件表示

共同研究・競争的資金等の研究課題

  • 最小バイオフィルム撲滅濃度を基準とする整形外科インプラント感染症の患者特異的治療戦略の探索

    研究課題/領域番号：24K12336  2024年4月 - 2028年3月

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    安部 晃生, 崔 賢民

    　 詳細を見る

    配分額：4420000円 （ 直接経費：3400000円 、 間接経費：1020000円 ）

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