Updated on 2026/06/24

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写真a

 
Taishi Wada
 
Organization
School of Medicine Medical Course Neurology and Stroke Medicine Assistant Professor
Title
Assistant Professor
External link

Research Interests

  • 神経変性疾患

Research Areas

  • Life Science / Neurology

Education

  • Yokohama City University   School of Medicine Medical Course

    2021.4 - 2025.3

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Research History

  • Yokohama City University   Hospital Neurology   Assistant Professor

    2025.4

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    Country：Japan

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Papers

  • 全身性炎症によって引き起こされるCCR2陽性単球の中枢神経系浸潤はALSの進行を加速する(Systemic inflammation-driven CNS infiltration of CCR2+ monocyte accelerates ALS progression)

    小笠原 陽大, 竹内 英之, 古宮 裕泰, 池田 拓也, 高橋 慶太, 浅野 徹也, 福田 裕美, 和田 大司, 橋口 俊太, 中村 治子, 土井 宏, 田中 章景

    神経免疫学   30 ( 1 )   221 - 221   2025.8

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    Language：English   Publisher：(一社)日本神経免疫学会  

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  • インターロイキン19による血液脳関門破綻の抑制

    古宮 裕泰, 竹内 英之, 小笠原 陽大, 和田 大司, 橋口 俊太, 中村 治子, 高橋 慶太, 土井 宏, 田中 章景

    神経免疫学   30 ( 1 )   199 - 199   2025.8

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    Language：Japanese   Publisher：(一社)日本神経免疫学会  

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  • Complete nanopore repeat sequencing of SCA27B (GAA-FGF14 ataxia) in Japanese. International journal

    Satoko Miyatake, Hiroshi Doi, Hiroaki Yaguchi, Eriko Koshimizu, Naoki Kihara, Tomoyasu Matsubara, Yasuko Mori, Kenjiro Kunieda, Yusaku Shimizu, Tomoko Toyota, Shinichi Shirai, Masaaki Matsushima, Masaki Okubo, Taishi Wada, Misako Kunii, Ken Johkura, Ryosuke Miyamoto, Yusuke Osaki, Takabumi Miyama, Mai Satoh, Atsushi Fujita, Yuri Uchiyama, Naomi Tsuchida, Kazuharu Misawa, Kohei Hamanaka, Haruka Hamanoue, Takeshi Mizuguchi, Hiroyuki Morino, Yuishin Izumi, Takayoshi Shimohata, Kunihiro Yoshida, Hiroaki Adachi, Fumiaki Tanaka, Ichiro Yabe, Naomichi Matsumoto

    Journal of neurology, neurosurgery, and psychiatry   95 ( 12 )   1187 - 1195   2024.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Although pure GAA expansion is considered pathogenic in SCA27B, non-GAA repeat motif is mostly mixed into longer repeat sequences. This study aimed to unravel the complete sequencing of FGF14 repeat expansion to elucidate its repeat motifs and pathogenicity. METHODS: We screened FGF14 repeat expansion in a Japanese cohort of 460 molecularly undiagnosed adult-onset cerebellar ataxia patients and 1022 controls, together with 92 non-Japanese controls, and performed nanopore sequencing of FGF14 repeat expansion. RESULTS: In the Japanese population, the GCA motif was predominantly observed as the non-GAA motif, whereas the GGA motif was frequently detected in non-Japanese controls. The 5'-common flanking variant was observed in all Japanese GAA repeat alleles within normal length, demonstrating its meiotic stability against repeat expansion. In both patients and controls, pure GAA repeat was up to 400 units in length, whereas non-pathogenic GAA-GCA repeat was larger, up to 900 units, but they evolved from different haplotypes, as rs534066520, located just upstream of the repeat sequence, completely discriminated them. Both (GAA)≥250 and (GAA)≥200 were enriched in patients, whereas (GAA-GCA)≥200 was similarly observed in patients and controls, suggesting the pathogenic threshold of (GAA)≥200 for cerebellar ataxia. We identified 14 patients with SCA27B (3.0%), but their single-nucleotide polymorphism genotype indicated different founder alleles between Japanese and Caucasians. The low prevalence of SCA27B in Japanese may be due to the lower allele frequency of (GAA)≥250 in the Japanese population than in Caucasians (0.15% vs 0.32%-1.26%). CONCLUSIONS: FGF14 repeat expansion has unique features of pathogenicity and allelic origin, as revealed by a single ethnic study.

    DOI： 10.1136/jnnp-2024-333541

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  • Hereditary spastic paraplegia and extensive leukoencephalopathy: a case report of a unique phenotype associated with a GJB1/Cx32 p.Pro174Ser variant. International journal

    Haruko Nakamura, Hiroshi Doi, Yosuke Miyaji, Taishi Wada, Erisa Takahashi, Mikiko Tada, Hiromi Fukuda, Atsushi Fujita, Yuichi Higashiyama, Yuri Nagao, Kazue Kimura, Masaharu Hayashi, Kyoko Hoshino, Naomichi Matsumoto, Fumiaki Tanaka

    BMC neurology   24 ( 1 )   310 - 310   2024.9

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    BACKGROUND: Pathogenic variants in Gap junction protein beta 1 (GJB1), which encodes Connexin 32, are known to cause X-linked Charcot-Marie-Tooth disease (CMTX), the second most common form of CMT. CMTX presents with the following five central nervous systems (CNS) phenotypes: subclinical electrophysiological abnormalities, mild fixed abnormalities on neurological examination and/or imaging, transient CNS dysfunction, cognitive impairment, and persistent CNS manifestations. CASE PRESENTATION: A 40-year-old Japanese male showed CNS symptoms, including nystagmus, prominent spastic paraplegia, and mild cerebellar ataxia, accompanied by subclinical peripheral neuropathy. Brain magnetic resonance imaging revealed hyperintensities in diffusion-weighted images of the white matter, particularly along the pyramidal tract, which had persisted since childhood. Nerve conduction assessment showed a mild decrease in motor conduction velocity, and auditory brainstem responses beyond wave II were absent. Peripheral and central conduction times in somatosensory evoked potentials elicited by stimulation of the median nerve were prolonged. Genetic analysis identified a hemizygous GJB1 variant, NM_000166.6:c.520C > T p.Pro174Ser. CONCLUSIONS: The patient in the case described here, with a GJB1 p.Pro174Ser variant, presented with a unique CNS-dominant phenotype, characterized by spastic paraplegia and persistent extensive leukoencephalopathy, rather than CMTX. Similar phenotypes have also been observed in patients with GJC2 and CLCN2 variants, likely because of the common function of these genes in regulating ion and water balance, which is essential for maintaining white matter function. CMTX should be considered within the spectrum of GJB1-related disorders, which can include patients with predominant CNS symptoms, some of which can potentially be classified as a new type of spastic paraplegia.

    DOI： 10.1186/s12883-024-03823-9

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  • RNA Foci in Two bi-Allelic RFC1 Expansion Carriers. International journal

    Taishi Wada, Hiroshi Doi, Masaki Okubo, Mikiko Tada, Naohisa Ueda, Hidefumi Suzuki, Wakana Tominaga, Haruki Koike, Hiroyasu Komiya, Shun Kubota, Shunta Hashiguchi, Haruko Nakamura, Keita Takahashi, Misako Kunii, Kenichi Tanaka, Yosuke Miyaji, Yuichi Higashiyama, Eriko Koshimizu, Satoko Miyatake, Masahisa Katsuno, Satoshi Fujii, Hidehisa Takahashi, Naomichi Matsumoto, Hideyuki Takeuchi, Fumiaki Tanaka

    Annals of neurology   95 ( 3 )   607 - 613   2024.3

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    Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) is a late-onset, autosomal recessive neurodegenerative disorder caused by biallelic AAGGG/ACAGG repeat expansion (AAGGG-exp/ACAGG-exp) in RFC1. The recent identification of patients with CANVAS exhibiting compound heterozygosity for AAGGG-exp and truncating variants supports the loss-of-function of RFC1 in CANVAS patients. We investigated the pathological changes in 2 autopsied patients with CANVAS harboring biallelic ACAGG-exp and AAGGG-exp. RNA fluorescence in situ hybridization of the 2 patients revealed CCTGT- and CCCTT-containing RNA foci, respectively, in neuronal nuclei of tissues with neuronal loss. Our findings suggest that RNA toxicity may be involved in the pathogenesis of CANVAS. ANN NEUROL 2024;95:607-613.

    DOI： 10.1002/ana.26848

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  • Rapid and comprehensive diagnostic method for repeat expansion diseases using nanopore sequencing. International journal

    Satoko Miyatake, Eriko Koshimizu, Atsushi Fujita, Hiroshi Doi, Masaki Okubo, Taishi Wada, Kohei Hamanaka, Naohisa Ueda, Hitaru Kishida, Gaku Minase, Atsuhiro Matsuno, Minori Kodaira, Katsuhisa Ogata, Rumiko Kato, Atsuhiko Sugiyama, Ayako Sasaki, Takabumi Miyama, Mai Satoh, Yuri Uchiyama, Naomi Tsuchida, Haruka Hamanoue, Kazuharu Misawa, Kiyoshi Hayasaka, Yoshiki Sekijima, Hiroaki Adachi, Kunihiro Yoshida, Fumiaki Tanaka, Takeshi Mizuguchi, Naomichi Matsumoto

    NPJ genomic medicine   7 ( 1 )   62 - 62   2022.10

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    We developed a diagnostic method for repeat expansion diseases using a long-read sequencer to improve currently available, low throughput diagnostic methods. We employed the real-time target enrichment system of the nanopore GridION sequencer using the adaptive sampling option, in which software-based target assignment is available without prior sample enrichment, and built an analysis pipeline that prioritized the disease-causing loci. Twenty-two patients with various neurological and neuromuscular diseases, including 12 with genetically diagnosed repeat expansion diseases and 10 manifesting cerebellar ataxia, but without genetic diagnosis, were analyzed. We first sequenced the 12 molecularly diagnosed patients and accurately confirmed expanded repeats in all with uniform depth of coverage across the loci. Next, we applied our method and a conventional method to 10 molecularly undiagnosed patients. Our method corrected inaccurate diagnoses of two patients by the conventional method. Our method is superior to conventional diagnostic methods in terms of speed, accuracy, and comprehensiveness.

    DOI： 10.1038/s41525-022-00331-y

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  • Ocular flutter as the presenting manifestation of autoimmune glial fibrillary acidic protein astrocytopathy. International journal

    Taishi Wada, Yuichi Higashiyama, Misako Kunii, Takashi Jono, Takuo Kobayashi, Shun Kubota, Mikiko Tada, Makoto Hara, Akio Kimura, Hiroshi Doi, Hideyuki Takeuchi, Fumiaki Tanaka

    Clinical neurology and neurosurgery   219   107307 - 107307   2022.8

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    A 39-year-old man exhibited ocular flutter and cerebellar ataxia following a subacute disturbance of consciousness and partial seizure. He was diagnosed with autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy by tissue- and cell-based antibody assays. Brain single-photon emission computed tomography detected a significant increase in blood flow in the fastigial nucleus, a critical region for eye saccade control. Immunotherapies diminished the ocular flutter and reduced hyperperfusion in the fastigial nucleus. This case suggests that autoimmune GFAP astrocytopathy can cause ocular flutter and provides strong imaging evidence supporting the hypothesis that ocular flutter is caused by hyperactivity or disinhibition of the fastigial nucleus.

    DOI： 10.1016/j.clineuro.2022.107307

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  • 発熱・意識障害で発症し、経過中にocular flutterを呈した抗GFAP抗体陽性髄膜脳炎の39歳男性例

    和田 大司, 東山 雄一, 高橋 慶太, 國井 美紗子, 木村 暁夫, 原 誠, 竹内 英之, 田中 章景

    臨床神経学   62 ( 1 )   80 - 80   2022.1

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    Language：Japanese   Publisher：(一社)日本神経学会  

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  • [An anti-RNP antibody-positive case of aseptic meningitis induced by non-steroidal anti-inflammatory drugs in a young woman].

    Taro Matsui, Keiichi Nakagawa, Keishi Yamazaki, Taishi Wada, Masato Kadoya, Kenichi Kaida

    Rinsho shinkeigaku = Clinical neurology   58 ( 1 )   25 - 29   2018.1

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Societas Neurologica Japonica  

    A 19-year-old woman developed high fever, headache, and nausea after taking Loxoprofen for pharyngitis, followed by disturbed consciousness and nuchal stiffness. The patient and her mother had a history of Raynaud's phenomenon. Cerebrospinal fluid (CSF) examination indicated a diagnosis of aseptic meningitis and revealed high levels of Q albumin and IgG index. Anti-RNP antibodies were positive in serum and CSF. Her symptoms disappeared immediately after cessation of Loxoprofen and a drug lymphocyte stimulation test was negative, confirming a diagnosis of non-steroidal anti-inflammatory drugs (NSAIDs)-induced aseptic meningitis. It should be kept in mind that an immune abnormality such as serum and CSF anti-RNP antibodies may play a role in development of NSAIDs-induced aseptic meningitis. A history of usage of NSAIDs and a thorough examination of collagen diseases are useful for identification of the origin of aseptic meningitis in a young woman.

    DOI： 10.5692/clinicalneurol.cn-001085

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    Other Link： https://search.jamas.or.jp/link/ui/2018153761

  • 消炎鎮痛剤で無菌性髄膜炎が誘発された抗RNP抗体陽性の若年女性例 Reviewed

    松井 太郎, 中川 慶一, 山崎 啓史, 和田 大司, 角谷 真人, 角谷 彰子, 池脇 克則, 海田 賢一

    防衛衛生   64 ( 別冊 )   42 - 42   2016.12

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  • 筋強剛が先行し過剰驚愕症・脳幹機能障害・自律神経障害を呈した抗glycine受容体抗体関連疾患の71歳男性例 Reviewed

    山崎 啓史, 角谷 真人, 中川 慶一, 和田 大司, 角谷 彰子, 高崎 寛, 池脇 克則, 海田 賢一

    神経治療学   33 ( 5 )   S219 - S219   2016.10

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  • 筋強剛が先行し過剰驚愕症・脳幹機能障害・自律神経障害を呈した抗glycine受容体抗体関連疾患の71歳男性例 Reviewed

    山崎 啓史, 角谷 真人, 中川 慶一, 和田 大司, 角谷 彰子, 高崎 寛, 池脇 克則, 海田 賢一

    神経免疫学   21 ( 1 )   109 - 109   2016.9

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  • 消炎鎮痛剤投与で無菌性髄膜炎が誘発された抗RNP抗体陽性の19歳女性例 Reviewed

    中川 慶一, 松井 太郎, 山崎 啓史, 和田 大司, 角谷 真人, 尾上 祐行, 池脇 克典, 海田 賢一

    臨床神経学   56 ( 3 )   218 - 218   2016.3

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  • IVIg反復投与で改善した抗gAChR抗体陽性自己免疫性自律神経ニューロパチーの45歳男性例 Reviewed

    和田 大司, 角谷 真人, 尾上 祐行, 池脇 克則, 海田 賢一

    防衛衛生   62 ( 別冊 )   76 - 76   2014.12

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  • 高力価抗gAChR抗体陽性自己免疫性自律神経ニューロパチーにおけるIVIgの効果 Reviewed

    和田 大司, 角谷 真人, 尾上 祐行, 池脇 克則, 海田 賢一

    臨床神経学   54 ( Suppl. )   S12 - S12   2014.12

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  • Acute spinal subdural hematoma in a patient with active systemic lupus erythematosus: a case report and literature review.

    Koji Akita, Taishi Wada, Shunpei Horii, Mitsuyo Matsumoto, Takeshi Adachi, Fumihiko Kimura, Kenji Itoh

    Internal medicine (Tokyo, Japan)   53 ( 8 )   887 - 90   2014

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    We herein describe a case of acute spinal subdural hematoma (SSDH) during the administration of high-dose corticosteroids and intravenous heparin for the treatment of active lupus nephritis. After SSDH was promptly diagnosed using magnetic resonance imaging (MRI), the patient recovered well with conservative treatment involving the discontinuation of heparin sodium. Although SSDH is a rare complication, it should be considered as a cause of neurological manifestations in patients with active systemic lupus erythematosus.

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MISC

  • CNS-dominant phenotypes in X-liked Charcot-Marie-Tooth disease (CMTX) with a GJB1 p.Pro174Ser variant

    中村治子, 土井宏, 和田大司, 高橋えり沙, 多田美紀子, 福田裕美, 東山雄一, 松本直通, 宮地洋輔, 田中章景

    臨床神経生理学(Web)   52 ( 5 )   2024

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  • GJB1 P174Sバリアントを認め,中枢神経優位の症状を呈したCMTXの40歳男性例

    高橋えり沙, 中村治子, 宮地洋輔, 和田大司, 福田裕美, 松本直通, 土井宏, 田中章景

    臨床神経学(Web)   64 ( 6 )   2024

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  • 発熱・意識障害で発症し,経過中にocular flutterを呈した抗GFAP抗体陽性髄膜脳炎の39歳男性例

    和田大司, 東山雄一, 高橋慶太, 國井美紗子, 木村暁夫, 原誠, 竹内英之, 田中章景

    臨床神経学(Web)   62 ( 1 )   2022

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  • 腋窩多汗症に対するA型ボツリヌス毒素局注療法後に広範な筋無力症状を認めた1例

    城野誉士, 宮地洋輔, 東山雄一, 小林卓雄, 和田大司, 窪田瞬, 國井美紗子, 多田美紀子, 竹内英之, 土井宏, 田中章景

    臨床神経生理学(Web)   48 ( 5 )   2020

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  • Fisher症候群類縁疾患におけるCa2+依存性IgG抗GQ1b抗体測定の有用性の検討 Reviewed

    山崎 啓史, 和田 大司, 内堀 歩, 千葉 厚郎, 堀内 碧, 松井 太郎, 古屋 佑一郎, 角谷 真人, 池脇 克則, 海田 賢一

    日本内科学会雑誌   108 ( Suppl. )   205 - 205   2019.2

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  • 抗NMDA受容体抗体関連脳炎に対するリツキシマブの有効性の検討 Reviewed

    石井 玲奈, 和田 大司, 角谷 真人, 中川 慶一, 山崎 啓史, 角谷 彰子, 池脇 克則, 海田 賢一

    防衛衛生   66 ( 別冊 )   48 - 48   2018.12

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  • 抗VGKC抗体陰性Isaacs症候群における臨床的、電気生理学的解析と筋超音波所見の特徴 Reviewed

    古屋 佑一郎, 和田 大司, 中川 慶一, 松井 太郎, 堀内 碧, 山崎 啓史, 高崎 寛, 角谷 真人, 海田 賢一

    臨床神経生理学   46 ( 5 )   546 - 546   2018.10

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  • 関節リウマチに対する疾患修飾薬のみで重症筋無力症の寛解を長期に維持できた64歳女性例 Reviewed

    田中 碧, 中川 慶一, 山崎 啓史, 和田 大司, 角谷 真人, 角谷 彰子, 池脇 克則, 海田 賢一

    神経治療学   34 ( 6 )   S206 - S206   2017.11

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  • 抗NMDA受容体抗体脳炎に対するrituximabの有効性の検討 Reviewed

    和田 大司, 角谷 真人, 中川 慶一, 山崎 啓史, 角谷 彰子, 池脇 克則, 海田 賢一

    日本内科学会雑誌   106 ( Suppl. )   184 - 184   2017.2

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  • 難治性てんかん重積を呈し、Rituximab及びCyclophosphamide投与が奏功した抗NMDA受容体抗体脳炎の48歳女性例

    和田 大司, 角谷 真人, 冨樫 尚彦, 森口 幸太, 角谷 彰子, 東原 真奈, 尾上 祐行, 池脇 克則, 海田 賢一

    防衛衛生   60 ( 別冊 )   42 - 42   2013.1

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