Updated on 2026/02/02

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写真a

 
Yutaro Takayama
 
Organization
YCU Medical Center Neurosurgery Assistant Professor
Title
Assistant Professor
Profile

頭蓋内脳波（SEEG）や脳深部刺激（DBS）などから得られる神経生理学的データをもとに、ヒト脳におけるネットワーク動態の理解と、それに基づくてんかん外科治療の高度化に取り組んでいる。特に、てんかん脳のネットワークにおける安静時レジリエンス機構に注目し、その結合様式とその可塑性を解析している。また、切除による制御が困難なてんかんに対して、定位的脳波記録に基づくラジオ波熱凝固術（RFTC）やDBSなどの低侵襲治療を展開し、ネットワークを意識した個別化治療戦略の確立を目指している。さらに、工学・情報科学分野との連携を通じて、脳波・刺激応答データを統合した新たな神経情報解析法を開発し、てんかんの病態理解から治療最適化に至るまでの一貫した枠組みの構築を進めている。

2010年に横浜市立大学医学部医学科を卒業後、横浜労災病院で初期臨床研修を修了。2012年より横浜市立大学附属病院脳神経外科に勤務し、その後、神奈川県立こども医療センター、平塚共済病院、東北大学てんかん学分野、国立精神・神経医療研究センター病院脳神経外科などで臨床と研究に従事した。2023年に横浜市立大学大学院医学研究科で博士号（医学）を取得し、同年より横浜市立大学附属病院脳神経外科助教を務める。2024年にはトロント大学The Hospital for Sick Children（SickKids）に研究員として在籍し、視床を中心としたヒトの意識制御ネットワークの国際共同研究を展開している。専門は脳神経外科、てんかん外科、機能神経外科、臨床神経生理学。日本脳神経外科学会専門医・指導医、日本てんかん学会専門医、日本定位・機能神経外科学会機能的定位脳手術技術認定医、日本小児神経外科学会認定医、日本臨床神経生理学会脳波分野認定医の資格を有する。

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Degree

  • MD.,PhD. ( 2023.3   Yokohama City University )

Research Interests

  • Intracranial EEG

  • Neurosurgery

  • Awakeness and Consciousness

  • Deep Brain Stimulation

  • Neuromodulation

  • Brain Network

  • Epilepsy surgery

Research Areas

  • Life Science / Neuroscience-general  / Human brain network

Education

  • Yokohama City University   School of Medicine Medical Course

    2004.4 - 2010.3

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    Country： Japan

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  • Yokohama City University   Graduate School of Medicine

    2019.4

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    Country： Japan

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Research History

  • Yokohama City University   Medical Center Neurosurgery   Assistant Professor

    2025.4

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  • Hospital for Sick Children (Sick Kids, University of Toronto), Toronto, Canada   Researcher (International Joint Research)

    2024.4 - 2025.3

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    Country：Canada

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  • Yokohama City University Graduate School of Medicine   Department of Neurosurgery   Assistant Professor

    2023.4 - 2024.3

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    Country：Japan

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  • フェリス女学院大学 音楽芸術学科 非常勤講師

    2022.9 - 2024.3

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  • Yokohama City University   Hospital oncogene

    2022.4 - 2023.3

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  • Yokohama City University   Hospital Neurosurgery

    2022.4 - 2023.3

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  • National Center of Neurology and Psychiatry

    2018.4 - 2022.3

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  • Tohoku University   University Hospital Epileptology

    2017.4 - 2018.3

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  • 平塚共済病院   脳神経外科

    2016.4 - 2017.3

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  • 横浜労災病院   脳神経外科

    2013.10 - 2016.3

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  • 神奈川県立こども医療センター   脳神経外科

    2013.4 - 2013.9

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  • Yokohama City University   Medical Center Neurosurgery

    2012.10 - 2013.3

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  • Yokohama City University   Hospital Neurosurgery

    2012.4 - 2012.9

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  • 横浜労災病院   初期臨床研修医

    2010.4 - 2012.3

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Professional Memberships

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Committee Memberships

  • Japan Young Epilepsy Section   Secretary  

    2019.11 - 2022.10   

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    Committee type：Academic society

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Papers

  • Volume-Based Stereotactic Radiofrequency Thermocoagulation for Drug-Resistant Focal Epilepsy: Preliminary Multicenter Report From Japan. International journal

    Masaki Iwasaki, Takahiro Hayashi, Keiya Iijima, Yuiko Kimura, Naoki Ikegaya, Yutaro Takayama, Masaki Sonoda, Takashi Morishita, Koichi Hagiwara, Masafumi Fukuda, Tomotaka Ishizaki, Satoshi Maesawa

    Operative neurosurgery (Hagerstown, Md.)   2025.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND AND OBJECTIVES: Although volume-based stereotactic radiofrequency thermocoagulation (RFTC) is being increasingly employed, data regarding its clinical outcomes and patient selection criteria remain limited. This study aimed to elucidate the current status of RFTC for epilepsy in a multicenter Japanese cohort. METHODS: This retrospective study included 23 patients who underwent volume-based RFTC for drug-resistant focal epilepsy between January 2021 and April 2024. Preoperative and postoperative clinical data were collected and analyzed in relation to postoperative seizure outcomes. RESULTS: The median age at surgery was 16 years, with a median follow-up of 27 months. The most frequent etiology was focal cortical dysplasia (60.9%). Surgical planning was primarily based on magnetic resonance imaging and positron emission tomography findings, supplemented by stereo-electroencephalography in most cases. The median number of ablations per patient was 23, ranging from 5 to 51. The treatment area included the insulo-opercular cortices in 11 patients and the medial temporal lobe in 5 patients. No surgical complications occurred, although transient and permanent neurological deficits were observed in 34.8% and 13.0% of patients, respectively. Seizure freedom was achieved in 59.1% of patients at 1 year and 34.8% at the last follow-up. Prior epilepsy surgery was significantly associated with poorer seizure outcomes (P = .02). No other preoperative factors demonstrated a significant association with seizure freedom. CONCLUSION: Volume-based RFTC seems to be a safe and effective, less invasive surgical option for selected patients with drug-resistant focal epilepsy, particularly those with deep-seated lesions or those involving eloquent cortex. While short-term seizure control is encouraging, long-term outcomes remain suboptimal, underscoring the need for improved patient selection and standardized treatment protocols.

    DOI： 10.1227/ons.0000000000001869

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  • Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy. International journal

    Tsuyoshi Eiro, Tomoyuki Miyazaki, Mai Hatano, Waki Nakajima, Tetsu Arisawa, Yuuki Takada, Kimito Kimura, Akane Sano, Kotaro Nakano, Takahiro Mihara, Yutaro Takayama, Naoki Ikegaya, Masaki Iwasaki, Akitoyo Hishimoto, Yoshihiro Noda, Takahiro Miyazaki, Hiroyuki Uchida, Hideaki Tani, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Masaru Mimura, Nozomu Matsuda, Kazuaki Kanai, Kazuhiro Takahashi, Hiroshi Ito, Yoji Hirano, Yuichi Kimura, Riki Matsumoto, Akio Ikeda, Takuya Takahashi

    Cell reports. Medicine   4 ( 5 )   101020 - 101020   2023.4

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    DOI： 10.1016/j.xcrm.2023.101020

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  • Drug-resistant temporal lobe epilepsy due to middle fossa meningoencephalocele in a child: A surgical case report. International journal

    Yasuo Sunaga, Yutaro Takayama, Suguru Yokosako, Takahisa Mizuno, Miyuki Kouno, Masahiko Tashiro, Masaki Iwasaki, Masayuki Sasaki

    Brain & development   45 ( 1 )   82 - 86   2023.1

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    DOI： 10.1016/j.braindev.2022.08.008

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  • Is Hippocampal Resection Necessary for Low-Grade Epilepsy-Associated Tumors in the Temporal Lobe? International journal

    Yutaro Takayama, Naoki Ikegaya, Keiya Iijima, Yuiko Kimura, Kenzo Kosugi, Suguru Yokosako, Yuu Kaneko, Tetsuya Yamamoto, Masaki Iwasaki

    Brain sciences   12 ( 10 )   2022.10

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    DOI： 10.3390/brainsci12101381

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  • Epileptic discharges initiate from brain areas with elevated accumulation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors. Reviewed International journal

    Tomoyuki Miyazaki, Yutaro Takayama, Masaki Iwasaki, Mai Hatano, Waki Nakajima, Naoki Ikegaya, Tetsuya Yamamoto, Shohei Tsuchimoto, Hiroki Kato, Takuya Takahashi

    Brain communications   4 ( 2 )   fcac023   2022

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    DOI： 10.1093/braincomms/fcac023

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  • Predictors of Seizure Outcome after Repeat Pediatric Epilepsy Surgery: Reasons for Failure, Sex, Electrophysiology, and Temporal Lobe Surgery. Reviewed

    Masaki Iwasaki, Keiya Iijima, Yutaro Takayama, Takahiro Kawashima, Hisateru Tachimori, Yuiko Kimura, Suguru Yokosako, Kenzo Kosugi, Yuu Kaneko

    Neurologia medico-chirurgica   62 ( 3 )   125 - 132   2021.12

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    Considering that seizure freedom is one of the most important goals in the treatment of epilepsy, repeat epilepsy surgery could be considered for patients who continue to experience drug-resistant seizures after epilepsy surgery. However, the chance of seizure freedom is reported to be below 50% after reoperation for failed epilepsy surgery. This study aimed to elucidate the predictive factors for seizure outcomes after repeat pediatric epilepsy surgery. In all, 39 pediatric patients who underwent repeat curative epilepsy surgery between 2008 and 2020 at our institution were retrospectively studied. The relationship between preoperative clinical factors and postoperative seizure freedom at the last follow-up was statistically evaluated. The mean age at the first surgery was 5.5 years (0-16). The etiology of epilepsy was malformation of cortical development in 33 patients. The average time to seizure recurrence after the first surgery was 6.4 months (range, 0-26 months). In all, 16 patients (41.0%) achieved seizure freedom after the second surgery. Seven patients underwent a third surgery, and three (42.9%) achieved seizure freedom. Overall, 19 patients achieved seizure freedom after repeat epilepsy surgery (48.7%). Female sex, surgical failure due to technical limitations, congruent electroencephalography (EEG) findings, lesional magnetic resonance imaging (MRI) and Rt-sided surgery were predictive of seizure freedom, and surgery limited to the temporal lobe was predictive of residual seizures, as determined in the multivariate analysis. The reoperation of failed epilepsy surgery is challenging. Consideration of the above predictive factors can be helpful in deciding whether to reoperate on pediatric patients whose initial surgical intervention failed.

    DOI： 10.2176/nmc.oa.2021-0315

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  • Efficient Detection of High-frequency Biomarker Signals of Epilepsy by a Transfer-learning-based Convolutional Neural Network

    Yuki Takayanagi, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Yumie Ono

    Advanced Biomedical Engineering   10   158 - 165   2021.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Medical and Biological Engineering  

    DOI： 10.14326/abe.10.158

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  • Epilepsy in Five Long-term Survivors of Pineal Region Tumors. Reviewed

    Yutaro Takayama, Kazutaka Jin, Shin-Ichiro Osawa, Masaki Iwasaki, Kazushi Ukishiro, Yosuke Kakisaka, Teiji Tominaga, Tetsuya Yamamoto, Nobukazu Nakasato

    NMC case report journal   8 ( 1 )   773 - 780   2021.11

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    Authorship：Lead author   Language：English  

    Cognitive decline is a well-known chronic side effect of multidisciplinary treatment of pineal region tumors, whereas epilepsy is an under-reported chronic consequence caused by multiple potential factors including radiotherapy, surgery, or chemotherapy. Some long-term survivors have suffered drug-resistant epilepsy after treatment, which impaired the quality of life. We report five consecutive patients with drug-resistant epilepsy after combined treatment of pineal region tumor (5 men, aged 21-42 years) among 1201 epilepsy patients who underwent comprehensive evaluation in our tertiary epilepsy center from 2011 to 2018. The comprehensive epilepsy evaluation included medical interview, long-term video electroencephalography (EEG) monitoring (VEM), and magnetic resonance (MR) imaging. The patients started to have seizures at 2-22 years after initial treatment for the tumor. Four of the five patients had focal impaired awareness seizures, whereas one patient had only visual aura. All patients had EEG seizures during VEM, which confirmed the diagnosis of focal epilepsy, but three patients had no interictal epileptiform discharges (IEDs). Two patients had diagnoses of focal epilepsy arising from the left occipital region based on ictal EEG findings. Both patients had MR imaging lesion in the left occipital lobe, radiation-induced cavernoma, or surgical injury. The remaining three patients showed poor localization of epileptogenic foci based on VEM and MR imaging. Drug-resistant epilepsy after multidisciplinary treatment of pineal region tumor is characterized by focal impaired awareness seizures with poorly localized EEG onset or rare interictal spikes.

    DOI： 10.2176/nmccrj.cr.2021-0093

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  • Withdrawal of deep brain stimulation in patients with gilles de la tourette syndrome. Reviewed International journal

    Yuiko Kimura, Naoki Ikegaya, Keiya Iijima, Yutaro Takayama, Yuu Kaneko, Mayu Omori, Takanobu Kaido, Yukiko Kano, Masaki Iwasaki

    Movement disorders : official journal of the Movement Disorder Society   34 ( 12 )   1925 - 1926   2019.12

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    DOI： 10.1002/mds.27909

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  • Palinopsia Accompanied with Migraine Attack After Having Occipital Brain Abscess. Reviewed International journal

    Yutaro Takayama, Junya Iwata, Akio Kojima

    Neuro-ophthalmology (Aeolus Press)   43 ( 5 )   327 - 329   2019.11

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    Authorship：Lead author,　Corresponding author   Language：English  

    Palinopsia is defined as persistence of recurrent visual images after the stimulus has been removed. A 55-year-old male patient with long-standing migraine history developed brain abscess in the right occipital lobe. The patient developed episodes of palinopsia accompanied with migraine attack after healing of occipital lesion. The phenomenon cannot be sufficiently explained with single risk factor, although occipital lesion and migraine are both known to cause palinopsia. We speculated that migrainous brain is not always symptomatic but may drive cortex sensitive for second insult, such as occipital brain lesion. The predisposition may contribute to appearance of palinopsia.

    DOI： 10.1080/01658107.2018.1519581

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  • Is intracranial electroencephalography useful for planning resective surgery in intractable epilepsy with ulegyria? Reviewed International journal

    Yutaro Takayama, Naoki Ikegaya, Keiya Iijima, Yuiko Kimura, Norihiro Muraoka, Yuu Kaneko, Tetsuya Yamamoto, Masaki Iwasaki

    Journal of neurosurgery   1 - 6   2019.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: Intractable epilepsy patients with ulegyria could be candidates for resective surgery. Complete resection of ulegyria in the epileptogenic hemisphere is associated with favorable seizure outcome, although the risk of postoperative functional deficits is higher. The authors evaluated the extent of resection and postsurgical outcomes in epilepsy patients with ulegyria who underwent intracranial electroencephalography (iEEG) monitoring prior to resection to clarify the efficacy of iEEG-guided partial resection of ulegyria. METHODS: Ten consecutive epilepsy patients with ulegyria (7 males and 3 females, age range at surgery 7-34 years) underwent iEEG prior to resective surgery between 2011 and 2017 with a minimum follow-up of 12 months (range 12-72 months). The diagnosis of ulegyria was based on the typical pattern of cortical atrophy especially at the bottom of the sulcus on MRI. An iEEG study was indicated after comprehensive preoperative evaluations, including high-field MRI, long-term video-EEG, magnetoencephalography, and FDG-PET. The resection planning was based on iEEG analysis. Total lesionectomy was not always performed, as preservation of cortical function was prioritized. RESULTS: Ulegyria was seen in the occipital and/or parietal lobe in 9 patients and bilaterally in 5 patients. Ictal EEG onset involved the temporal neocortex in 6 patients. Intracranial electrodes were implanted unilaterally in all except 1 patient with bilateral lesions. The extent of MRI lesion was covered by the electrodes. Seizure onset zones (SOZs) and irritative zones (IZs) were identified in all patients. SOZs and IZs were completely resected in 8 patients but were only partially removed in the remaining 2 patients because the eloquent cortices and the epileptogenic zones overlapped. Ulegyria of the epileptogenic side was totally resected in 1 patient. Seizure freedom was achieved in 4 patients, including 3 after partial lesionectomy. Extended resection of the temporal neocortex was performed in 4 patients, although postoperative seizure freedom was achieved only in 1 of these patients. Visual field deficit was seen in 4 patients. Three of 5 patients with bilateral lesions achieved seizure freedom after unilateral resective surgery. CONCLUSIONS: Intracranial EEG-guided partial lesionectomy provides a reasonable chance of postoperative seizure freedom with a lower risk of functional deficits. Patients with bilateral ulegyria should not be excluded from consideration as surgical candidates.

    DOI： 10.3171/2019.8.JNS191642

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  • Internal and External Validation of Comprehensive High-Frequency Activity Biomarkers for Epilepsy Surgery. International journal

    Keisuke Hatano, Naoto Kuroda, Hiroshi Uda, Kazuki Sakakura, Michael J Cools, Aimee F Luat, Shin-Ichiro Osawa, Hitoshi Nemoto, Kazushi Ukishiro, Hidenori Endo, Nobukazu Nakasato, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Eishi Asano

    medRxiv : the preprint server for health sciences   2025.12

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    Although epilepsy surgery studies have proposed intracranial EEG-derived biomarkers for localizing seizure onset and anticipating postoperative outcomes, evaluation has often been limited to derivation cohorts using internal cross-validation. An influential notion holds that neurons distributed within the seizure onset zone (SOZ) frequently generate high-frequency activity (HFA) and that resection of such sites is associated with favorable postoperative seizure control. However, the extent to which these prediction models generalize to independent patient populations-and across diverse underlying etiologies-has remained largely untested. In this international, multi-center study of drug-resistant focal epilepsy, we retrospectively quantified HFA occurrence rates together with a comprehensive set of morphological features and integrated these metrics into predictive models for SOZ localization and postoperative seizure outcome. We then assessed model performance in fully independent datasets-a temporal external cohort and two geographical external cohorts-each entirely separate from the derivation cohort. In total, 5,142,891 HFA events observed across 22,939 electrodes from 233 patients were analyzed. Among the model inputs, HFA rate, spectral entropy, and power emerged as the most influential features for accurate SOZ classification. The model reliably identified clinician-defined SOZ sites across centers, achieving areas under the curve (AUCs) of up to 0.85 in the derivation cohort using 10-fold cross-validation, up to 0.86 in the temporal external cohort, and up to 0.75 in the geographical external cohorts. Within the derivation cohort, the model predicted postoperative seizure freedom with an AUC of up to 0.70. In contrast, postoperative seizure outcomes could not be predicted reliably across the external cohorts. Specifically, among external-cohort patients with MRI non-lesional epilepsy, postoperative seizure freedom was predicted with an AUC of up to 0.73, whereas performance declined to 0.46 or below among patients with encephalomalacia, an etiology characterized by chronic parenchymal damage and marked neuronal loss. Together, integration of HFA occurrence rates with morphological features yields an SOZ-localization biomarker with cross-center generalizability, whereas postoperative outcome prediction remains highly dependent on underlying etiology. Notably, a surgical strategy that prioritizes resection of HFA-involved areas does not appear to be applicable to patients with encephalomalacia and may be ineffective or even counterproductive in this population. A total of 97.86 GB of iEEG data are publicly available to facilitate external validation by the epilepsy surgery research community and the development of improved biomarkers for epileptogenic zone localization.

    DOI： 10.64898/2025.12.17.25342490

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  • AMPA receptor palmitoylation restrains ictogenesis in the epileptogenic lesion of patients with hippocampal sclerosis. International journal

    Nami Suzuki, Akiko Oota-Ishigaki, Keiya Iijima, Yutaro Takayama, Yuiko Kimura, Kotaro Hattori, Masaki Iwasaki, Takashi Hayashi

    Biochemical pharmacology   242 ( Pt 4 )   117426 - 117426   2025.10

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    DOI： 10.1016/j.bcp.2025.117426

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  • Digital FDG-PET detects MYD88 mutation-driven glycolysis in primary central nervous system lymphoma. International journal

    Mayu Sasaki, Yuri Teraoka, Ayumi Kato, Tadaaki Nakajima, Yoshinobu Ishiwata, Yohei Miyake, Hirokuni Honma, Taishi Nakamura, Naoki Ikegaya, Yutaro Takayama, Osamu Yazawa, Shungo Sawamura, Akito Oshima, Hiroaki Hayashi, Wei Kai Ye, Kanoko Sasaoka, Yukie Yoshii, Satoshi Fujii, Ukihide Tateishi, Tetsuya Yamamoto, Daisuke Utsunomiya, Shingo Kato, Kensuke Tateishi

    AJNR. American journal of neuroradiology   2025.7

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    BACKGROUND AND PURPOSE: The relationship between digital 18F-fluorodeoxyglucose positron emission tomography (dFDG-PET) findings and glucose metabolism-related genetic alterations remains unclear in primary central nervous system lymphoma (PCNSL). This study aimed to evaluate whether dFDG-PET can serve as a noninvasive tool to detect MYD88 mutation-driven glycolytic activity in PCNSL. MATERIALS AND METHODS: We retrospectively analyzed the imaging and molecular data of 54 patients with PCNSL (55 lesions). MRI and FDG-PET parameters, including the maximum standardized uptake value (SUVmax) and tumor-to-background ratio (TBR), were assessed. Tumor specimens were subjected to histopathological and genomic evaluations, including the MYD88 mutation status. RESULTS: Among 55 tumors, 34 (61.8%) were examined with dFDG-PET and 21 (38.2%) with analog 18F-FDG-PET (aFDG-PET). In the dFDG-PET group, MYD88-mutant tumors showed significantly higher SUVmax (30.2 ± 9.9) and TBR (6.1 ± 1.5) compared to wild-type tumors (SUVmax: 19.3 ± 7.2, P = 0.006; TBR: 3.5 ± 1.3, P < 0.001). In the aFDG-PET group, the SUVmax was significantly higher in MYD88-mutant tumors (P = 0.01), whereas the TBR differences were not statistically significant (P = 0.38). Receiver operating characteristic analysis of TBR in dFDG-PET yielded an area under the curve of 0.913 (95% CI: 0.954-1.000) with a cutoff value of 4.49, achieving 88% sensitivity and 88% specificity for MYD88 mutation detection. Multivariate logistic regression identified SUVmax and TBR from dFDG-PET as independent predictors of MYD88 mutation status. The transcriptomic analysis confirmed the significant upregulation of glycolysis-related genes, including hexokinase 2, in MYD88-mutant tumors, supporting increased glycolytic activity. CONCLUSIONS: dFDG-PET may serve as a valuable noninvasive imaging modality to detect MYD88 mutation-driven enhanced glycolysis in patients with PCNSL. ABBREVIATIONS: dPET＝ Digital positron emission tomography; PCNSL＝ Primary central nervous system lymphoma; SUVmax＝maximum standardized uptake value; TBR＝ tumor-to background ratio.

    DOI： 10.3174/ajnr.A8935

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  • First-in-Human Study of 18F-Labeled PET Tracer for Glutamate AMPA Receptor [18F]K-40: A Derivative of [11C]K-2. International journal

    Sadamitsu Ichijo, Tetsu Arisawa, Mai Hatano, Waki Nakajima, Tomoyuki Miyazaki, Tsuyoshi Eiro, Yuuki Takada, Ryunosuke Iai, Akane Sano, Masaki Sonoda, Yutaro Takayama, Yuichi Kimura, Takuya Takahashi

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine   66 ( 6 )   932 - 939   2025.5

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    DOI： 10.2967/jnumed.124.269405

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  • Visualization of functional and effective connectivity underlying auditory descriptive naming. International journal

    Yu Kitazawa, Kazuki Sakakura, Hiroshi Uda, Naoto Kuroda, Riyo Ueda, Ethan Firestone, Min-Hee Lee, Jeong-Won Jeong, Masaki Sonoda, Shin-Ichiro Osawa, Kazushi Ukishiro, Makoto Ishida, Kazuo Kakinuma, Shoko Ota, Yutaro Takayama, Keiya Iijima, Toshimune Kambara, Hidenori Endo, Kyoko Suzuki, Nobukazu Nakasato, Masaki Iwasaki, Eishi Asano

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology   175   2010729 - 2010729   2025.4

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    DOI： 10.1016/j.clinph.2025.04.008

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  • Multi-modal Multitask Learning Model for Simultaneous Classification of Two Epilepsy Biomarkers

    Nawara Mahmood Broti, Masaki Sawada, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Yumie Ono

    PATTERN RECOGNITION, ICPR 2024, PT XII   15312   235 - 250   2025

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    Language：English   Publishing type：Research paper (international conference proceedings)  

    DOI： 10.1007/978-3-031-78198-8_16

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  • Chronic reduction of synaptic proteins in the epileptogenic lesion of patients with hippocampal sclerosis. International journal

    Akiko Oota-Ishigaki, Nami Suzuki, Keiya Iijima, Yutaro Takayama, Yuiko Kimura, Kotaro Hattori, Masaki Iwasaki, Takashi Hayashi

    Frontiers in molecular neuroscience   18   1635852 - 1635852   2025

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    DOI： 10.3389/fnmol.2025.1635852

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  • てんかん原性領域として同側海馬も示唆されたPolymorphous low-grade neuroepithelial tumor of the young(PLNTY)に伴う難治側頭葉てんかんの1例

    毛呂 貴宏, 園田 真樹, 高山 裕太郎, 岩下 広道, 山中 生二, 藤井 誠志, 立石 健祐, 山本 哲哉

    臨床神経生理学   52 ( 5 )   621 - 621   2024.10

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    Language：Japanese   Publisher：(一社)日本臨床神経生理学会  

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  • 脳室周囲を主とする、MPNST様肉腫成分が大部分を占める高齢者膠肉腫の一例

    岩下 広道, 奥寺 康司, 山中 正二, 高山 裕太郎, 山本 哲哉, 立石 健祐, 横尾 英明

    Brain Tumor Pathology   41 ( Suppl. )   143 - 143   2024.5

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  • 脳室周囲を主とする、MPNST様肉腫成分が大部分を占める高齢者膠肉腫の一例

    岩下 広道, 奥寺 康司, 山中 正二, 高山 裕太郎, 山本 哲哉, 立石 健祐, 横尾 英明

    Brain Tumor Pathology   41 ( Suppl. )   143 - 143   2024.5

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  • Intraventricular hemorrhage volume and younger age at surgery may be risk factors for postoperative hydrocephalus after hemispherotomy in children. Reviewed International journal

    Munetake Yoshitomi, Keiya Iijima, Kenzo Kosugi, Yutaro Takayama, Yuiko Kimura, Yuu Kaneko, Takahiro Kawashima, Hisateru Tachimori, Noriko Sumitomo, Shimpei Baba, Takashi Saito, Eiji Nakagawa, Motohiro Morioka, Masaki Iwasaki

    Journal of neurosurgery. Pediatrics   33 ( 3 )   193 - 198   2024.3

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    DOI： 10.3171/2023.11.PEDS23408

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  • Accuracy of Stereotactic electroencephalography (SEEG) using Cirq robotic arm system

    高山裕太郎, 池谷直樹, 園田真樹, 山本哲哉

    日本定位・機能神経外科学会プログラム・抄録集(Web)   63回   146 - 146   2024.1

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  • Anti-epileptic drug use and subsequent degenerative dementia occurrence. International journal

    Naoki Ikegaya, Honoka Nakamura, Yutaro Takayama, Yohei Miyake, Takahiro Hayashi, Masaki Sonoda, Mitsuru Sato, Kensuke Tateishi, Jun Suenaga, Masao Takaishi, Yu Kitazawa, Misako Kunii, Hiroki Abe, Tomoyuki Miyazaki, Tetsuaki Arai, Manabu Iwasaki, Takayuki Abe, Tetsuya Yamamoto

    Alzheimer's & dementia (New York, N. Y.)   10 ( 3 )   e70001   2024

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    DOI： 10.1002/trc2.70001

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  • Automated Detection of Interictal High-frequency Oscillations for Epileptogenic Zone Localization

    Nawara Mahmood Broti, Masaki Sawada, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Yumie Ono

    ADVANCED BIOMEDICAL ENGINEERING   13   100 - 107   2024

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    DOI： 10.14326/abe.13.100

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  • Arteries Around the Superior Limiting Sulcus: Motor Complication Avoidance in Insular and Insulo-Opercular Surgery. International journal

    Naoki Ikegaya, Takahiro Hayashi, Takefumi Higashijima, Yutaro Takayama, Masaki Sonoda, Masaki Iwasaki, Yohei Miyake, Mitsuru Sato, Kensuke Tateishi, Jun Suenaga, Tetsuya Yamamoto

    Operative neurosurgery (Hagerstown, Md.)   25 ( 6 )   e308-e314 - E314   2023.12

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    DOI： 10.1227/ons.0000000000000879

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  • Focal ictal direct current shifts by a time constant of 2 seconds were clinically useful for resective epilepsy surgery. International journal

    Masaki Izumi, Katsuya Kobayashi, Shunsuke Kajikawa, Kyoko Kanazawa, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Yoji Okahara, Seiichiro Mine, Yasuo Iwadate, Akio Ikeda

    Epilepsia   64 ( 12 )   3294 - 3306   2023.10

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    DOI： 10.1111/epi.17782

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  • Intraoperative integrated diagnostic system for malignant central nervous system tumors. International journal

    Takahiro Hayashi, Kensuke Tateishi, Shinichiro Matsuyama, Hiromichi Iwashita, Yohei Miyake, Akito Oshima, Hirokuni Homma, Jo Sasame, Katsuhiro Takabayashi, Kyoka Sugino, Emi Hirata, Naoko Udaka, Yuko Matsushita, Ikuma Kato, Hiroaki Hayashi, Taishi Nakamura, Naoki Ikegaya, Yutaro Takayama, Masaki Sonoda, Chihiro Oka, Mitsuru Sato, Masataka Isoda, Miyui Kato, Kaho Uchiyama, Tamon Tanaka, Toshiki Muramatsu, Shigeta Miyake, Ryosuke Suzuki, Mutsumi Takadera, Junya Tatezuki, Junichi Ayabe, Jun Suenaga, Shigeo Matsunaga, Kosuke Miyahara, Hiroshi Manaka, Hidetoshi Murata, Takaakira Yokoyama, Yoshihide Tanaka, Takashi Shuto, Koichi Ichimura, Shingo Kato, Shoji Yamanaka, Daniel P Cahill, Satoshi Fujii, Ganesh M Shankar, Tetsuya Yamamoto

    Clinical cancer research : an official journal of the American Association for Cancer Research   41st ( 1 )   116 - 126   2023.10

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    DOI： 10.1158/1078-0432.CCR-23-1660

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  • Development of Diagnostic and Therapeutic Devices for Intractable Epilepsy Using brand new Flexible Thin-Film Electrodes

    園田真樹, 藤枝俊宣, 宮下英三, 今井綾乃, 伊勢真由子, 関田大生, 高山裕太郎, 宮崎智之, 宮崎智之, 宮崎智之, 山本哲哉

    日本てんかん外科学会プログラム・抄録集   41 ( 2 )   394 - 394   2023.9

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  • Seizure Semiologies and SEEG Investigation of Three Pediatric Cases of Insular Epilepsy

    相原悠, 馬場信平, 飯島圭哉, 木村唯子, 高山裕太郎, 高山裕太郎, 本橋裕子, 齋藤貴志, 齋藤貴志, 中川栄二, 中川栄二, 岩崎真樹, 岩崎真樹

    てんかん研究   41 ( 2 )   341 - 341   2023.9

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  • IDH1変異グリオーママウスモデルにおける変異型IDH1阻害剤のてんかん抑制効果の検討

    林 貴啓, 立石 健祐, 池谷 直樹, 園田 真樹, 高山 裕太郎, 宮崎 智之, 中島 和希, 山本 哲哉

    てんかん研究   41 ( 2 )   440 - 440   2023.9

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  • Analysis of epileptic activity by mutant IDH1 Inhibitor in glioma patient-derived xenograft model

    林貴啓, 立石健祐, 池谷直樹, 園田真樹, 高山裕太郎, 宮崎智之, 中島和希, 山本哲哉

    てんかん研究   41 ( 2 )   440 - 440   2023.9

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  • Sevoflurane-based enhancement of phase-amplitude coupling and localization of the epileptogenic zone

    園田真樹, 和田圭伊子, FIRESTONE Ethan, 坂倉和樹, 黒田直生人, 黒田直生人, 高山裕太郎, 飯島圭哉, 岩崎真樹, 水原敬洋, 山本哲哉, 後藤隆久, 浅野英司, 宮崎智之

    てんかん研究   41 ( 2 )   413 - 413   2023.9

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  • Resection of the cervical portion of pre- and post-central gyri epileptogenic zone in a patient with a cavernous malformation

    岡野将之, 岡野将之, 池谷直樹, 林貴啓, 藤井啓太, 高山裕太郎, 権藤学司, 立石健祐, 山本哲哉

    脳神経外科速報   33 ( 4 )   e22 - e29   2023.7

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  • びまん性に進展像を呈したmolecular glioblastoma症例の検討

    伏見 修人, 三宅 勇平, 岩下 広道, 林 貴啓, 大島 聡人, 本間 博邦, 高山 裕太郎, 園田 真樹, 立石 健祐, 山本 哲哉

    Brain Tumor Pathology   40 ( Suppl. )   149 - 149   2023.5

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  • てんかん外科治療up-to-date-最新のてんかん原性領域診断とQOLを考慮した治療について- 小児の島・弁蓋部てんかんに対するラジオ波温熱凝固術

    高山 裕太郎, 木村 唯子, 飯島 圭哉, 小杉 健三, 吉富 宗健, 住友 典子, 馬場 信平, 本橋 裕子, 竹下 絵里, 齋藤 貴志, 中川 栄二, 山本 哲哉, 岩崎 真樹

    脳と発達   55 ( Suppl. )   S136 - S136   2023.5

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  • 発達期の脳を対象とした言語処理に関わる脳内ネットワークの6次元ダイナミックトラクトグラフィーアトラスとその臨床展望

    園田 真樹, 高山 裕太郎, 林 貴啓, 山本 哲哉

    小児の脳神経   48 ( 2 )   205 - 205   2023.4

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  • 小児の皮質形成異常に対するラジオ周波温熱凝固術

    岩崎 真樹, 高山 裕太郎, 飯島 圭哉, 木村 唯子, 吉富 宗健, 金子 裕, 住友 典子, 馬場 信平, 齋藤 貴志, 中川 栄二

    小児の脳神経   48 ( 2 )   197 - 197   2023.4

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  • Sevoflurane-induced high-frequency oscillations, effective connectivity and intraoperative classification of epileptic brain areas. International journal

    Ethan Firestone, Masaki Sonoda, Naoto Kuroda, Kazuki Sakakura, Jeong-Won Jeong, Min-Hee Lee, Keiko Wada, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Tomoyuki Miyazaki, Eishi Asano

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology   150   17 - 30   2023.3

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    DOI： 10.1016/j.clinph.2023.03.004

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  • Safety, Feasibility, and Efficacy of Additional Extraventricular Anterior Commissurotomy With Corpus Callosotomy. International journal

    Kenzo Kosugi, Munetake Yoshitomi, Yutaro Takayama, Keiya Iijima, Yuiko Kimura, Yuu Kaneko, Masahiro Toda, Masaki Iwasaki

    Operative neurosurgery (Hagerstown, Md.)   24 ( 2 )   e68-e74 - E74   2023.2

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    DOI： 10.1227/ons.0000000000000478

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  • 骨内動静脈瘻の解剖学的特徴と大後頭孔周囲の静脈ネットワークを介した経静脈的塞栓術

    飯田 悠, 清水 信行, 鈴木 良介, 三宅 勇平, 高山 裕太郎, 園田 真樹, 池谷 直樹, 堀 聡, 佐藤 充, 立石 健祐, 末永 潤, 山本 哲哉

    脳血管内治療   7 ( Suppl. )   S62 - S62   2022.11

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  • 骨内動静脈瘻の解剖学的特徴と大後頭孔周囲の静脈ネットワークを介した経静脈的塞栓術

    飯田 悠, 清水 信行, 鈴木 良介, 三宅 勇平, 高山 裕太郎, 園田 真樹, 池谷 直樹, 堀 聡, 佐藤 充, 立石 健祐, 末永 潤, 山本 哲哉

    脳血管内治療   7 ( Suppl. )   S62 - S62   2022.11

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  • Volume-Based Radiofrequency Thermocoagulation for Pediatric Insulo-Opercular Epilepsy: A Feasibility Study. International journal

    Yutaro Takayama, Yuiko Kimura, Keiya Iijima, Suguru Yokosako, Kenzo Kosugi, Kaoru Yamamoto, Yuko Shimizu-Motohashi, Yuu Kaneko, Tetsuya Yamamoto, Masaki Iwasaki

    Operative neurosurgery (Hagerstown, Md.)   23 ( 3 )   241 - 249   2022.9

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    BACKGROUND: Stereotactic ablation surgeries including radiofrequency thermocoagulation (RFTC) and laser interstitial thermal therapy are recent less invasive treatment methods for insular epilepsy. Volume-based RFTC after stereoelectroencephalography was first proposed by a French group as a more effective method for seizure relief in insular epilepsy patients than stereoelectroencephalography-guided RFTC. OBJECTIVE: To describe the feasibility and technical details about volume-based RFTC in patients with insulo-opercular epilepsy. METHODS: We successfully treated 3- and 6-year-old patients with medically refractory insulo-opercular epilepsy with volume-based RFTC, in which the target volume of coagulation was flexibly designed by combining multiple spherical models of 5-mm diameter which is smaller than reported previously. RESULTS: The insula was targeted by oblique trajectory from the frontoparietal area in one case, and the opercular cortex was targeted by perpendicular trajectories from the perisylvian cortex in the other case. The use of the small sphere model required more trajectories and manipulations but enabled more exhaustive coagulation of the epileptogenic zone, with 70% to 78% of the planned target volume coagulated without complications, and daily seizures disappeared after RFTC in both patients. CONCLUSION: Volume-based RFTC planned with small multiple sphere models may improve the completeness of lesioning for patients with insulo-opercular epilepsy. Careful planning is necessary to reduce the risks of vascular injuries.

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  • The risk of post-operative hydrocephalus after hemispherotomy in children

    吉富宗健, 飯島圭哉, 小杉健三, 小杉健三, 高山裕太郎, 高山裕太郎, 木村唯子, 川島貴大, 立森久照, 住友典子, 馬場信平, 齋藤貴志, 中川栄二, 岩崎真樹

    てんかん研究   40 ( 2 )   435 - 435   2022.8

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  • MR Imaging Detection of CNS Lesions in Tuberous Sclerosis Complex: The Usefulness of T1WI with Chemical Shift Selective Images

    H. Fujii, N. Sato, Y. Kimura, M. Mizutani, M. Kusama, N. Sumitomo, E. Chiba, Y. Shigemoto, M. Takao, Y. Takayama, M. Iwasaki, E. Nakagawa, H. Mori

    American Journal of Neuroradiology   43 ( 8 )   1202 - 1209   2022.8

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    DOI： 10.3174/ajnr.a7573

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  • 小児における大脳半球離断術後の水頭症リスクの検討

    吉富 宗健, 飯島 圭哉, 小杉 健三, 高山 裕太郎, 木村 唯子, 川島 貴大, 立森 久照, 住友 典子, 馬場 信平, 齋藤 貴志, 中川 栄二, 岩崎 真樹

    てんかん研究   40 ( 2 )   435 - 435   2022.8

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  • A post-hoc analysis of a nationwide survey about psychological distress in electroencephalography technicians during the COVID-19 pandemic in Japan: A text analysis of free description

    岩山孝幸, 岩山孝幸, 岩山孝幸, 黒田直生人, 久保田隆文, 堀之内徹, 池谷直樹, 北澤悠, 小玉聡, 松原鉄平, 梛野尚人, 音成秀一郎, 曽我天馬, 曽根大地, 高山裕太郎, 倉持泉, 黒田直生人, 久保田隆文, 堀之内徹, 池谷直樹, 北澤悠, 小玉聡, 松原鉄平, 梛野尚人, 音成秀一郎, 曽我天馬, 曽根大地, 高山裕太郎, 倉持泉

    てんかん研究   40 ( 2 )   447 - 447   2022.8

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  • Naming-related spectral responses predict neuropsychological outcome after epilepsy surgery

    園田真樹, 園田真樹, 林貴啓, 池谷直樹, 高山裕太郎, 東島威史, 飯村圭哉, 大沢伸一郎, 岩崎真樹, 中里信和, 山本哲哉, 浅野英司

    てんかん研究   40 ( 2 )   414 - 414   2022.8

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  • Impact of <scp>COVID</scp> ‐19 pandemic on epilepsy care in Japan: A national‐level multicenter retrospective cohort study

    Naoto Kuroda, Takafumi Kubota, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Izumi Kuramochi, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Yutaro Takayama, Daichi Sone, Kousuke Kanemoto, Akio Ikeda, Kiyohito Terada, Hiroko Goji, Shinji Ohara, Koichi Hagiwara, Takashi Kamada, Koji Iida, Nobutsune Ishikawa, Hideaki Shiraishi, Osato Iwata, Hidenori Sugano, Yasushi Iimura, Takuichiro Higashi, Hiroshi Hosoyama, Ryosuke Hanaya, Akihiro Shimotake, Takayuki Kikuchi, Takeshi Yoshida, Hiroshi Shigeto, Jun Yokoyama, Takahiko Mukaino, Masaaki Kato, Masanori Sekimoto, Masahiro Mizobuchi, Yoko Aburakawa, Masaki Iwasaki, Eiji Nakagawa, Tomohiro Iwata, Kentaro Tokumoto, Takuji Nishida, Yukitoshi Takahashi, Kenjiro Kikuchi, Ryuki Matsuura, Shin‐ichiro Hamano, Ayataka Fujimoto, Hideo Enoki, Kyoichi Tomoto, Masako Watanabe, Youji Takubo, Toshihiko Fukuchi, Hidetoshi Nakamoto, Yuichi Kubota, Naoto Kunii, Yuichiro Shirota, Eiichi Ishikawa, Nobukazu Nakasato, Taketoshi Maehara, Motoki Inaji, Shunsuke Takagi, Takashi Enokizono, Yosuke Masuda, Takahiro Hayashi

    Epilepsia Open   7 ( 3 )   431 - 441   2022.5

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    DOI： 10.1002/epi4.12616

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  • 小児てんかん外科再手術後の発作転帰を規定する因子

    岩崎 真樹, 飯島 圭哉, 高山 裕太郎, 川島 貴大, 立森 久照, 木村 唯子, 小杉 健三, 吉富 宗健, 金子 裕

    小児の脳神経   47 ( 2 )   216 - 216   2022.4

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  • Low EEG Gamma Entropy and Glucose Hypometabolism After Corpus Callosotomy Predicts Seizure Outcome After Subsequent Surgery. Reviewed International journal

    Kenzo Kosugi, Keiya Iijima, Suguru Yokosako, Yutaro Takayama, Yuiko Kimura, Yuu Kaneko, Noriko Sumitomo, Takashi Saito, Eiji Nakagawa, Noriko Sato, Masaki Iwasaki

    Frontiers in neurology   13   831126 - 831126   2022

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    Background: Patients with generalized epilepsy who had lateralized EEG abnormalities after corpus callosotomy (CC) occasionally undergo subsequent surgeries to control intractable epilepsy. Objectives: This study evaluated retrospectively the combination of EEG multiscale entropy (MSE) and FDG-PET for identifying lateralization of the epileptogenic zone after CC. Methods: This study included 14 patients with pharmacoresistant epilepsy who underwent curative epilepsy surgery after CC. Interictal scalp EEG and FDG-PET obtained after CC were investigated to determine (1) whether the MSE calculated from the EEG and FDG-PET findings was lateralized to the surgical side, and (2) whether the lateralization was associated with seizure outcomes. Results: Seizure reduction rate was higher in patients with lateralized findings to the surgical side than those without (MSE: p < 0.05, FDG-PET: p < 0.05, both: p < 0.01). Seizure free rate was higher in patients with lateralized findings in both MSE and FDG-PET than in those without (p < 0.05). Conclusions: This study demonstrated that patients with lateralization of MSE and FDG-PET to the surgical side had better seizure outcomes. The combination of MSE and conventional FDG-PET may help to select surgical candidates for additional surgery after CC with good postoperative seizure outcomes.

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  • Post-hoc analysis of a cross-sectional nationwide survey assessing psychological distress in electroencephalography technicians during the COVID-19 pandemic in Japan: Qualitative and quantitative text analysis of open-ended response data

    Naoto Kuroda, Takayuki Iwayama, Takafumi Kubota, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Daichi Sone, Yutaro Takayama, Izumi Kuramochi

    Epilepsy &amp; Seizure   14 ( 1 )   58 - 70   2022

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    DOI： 10.3805/eands.14.58

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  • Barriers to telemedicine among physicians in epilepsy care during the COVID-19 pandemic: A national-level cross-sectional survey in Japan. Reviewed International journal

    Takafumi Kubota, Naoto Kuroda, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Izumi Kuramochi, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Yutaro Takayama, Daichi Sone

    Epilepsy & behavior : E&B   126   108487 - 108487   2021.12

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    OBJECTIVE: This study aimed to investigate the factors affecting the unwillingness of physicians involved in epilepsy care to continue telemedicine during the coronavirus disease 2019 (COVID-19) pandemic in Japan. METHOD: This was a national-level cross-sectional survey initiated by Japan Young Epilepsy Section (YES-Japan) which is a national chapter of The Young Epilepsy Section of the International League Against Epilepsy (ILAE-YES). We asked physicians who conducted telemedicine in patients with epilepsy (PWE) during the COVID-19 pandemic at four clinics and 21 hospitals specializing in epilepsy care in Japan from March 1 to April 30, 2021. The following data were collected: (1) participant profile, (2) characteristics of PWE treated by telemedicine, and (3) contents and environmental factors of telemedicine. Statistically significant variables (p < 0.05) in the univariate analysis were analyzed in a multivariate binary logistic regression model to detect the independently associated factors with the unwillingness to continue telemedicine. RESULT: Among the 115 respondents (response rate: 64%), 89 were included in the final analysis. Of them, 60 (67.4%) were willing to continue telemedicine, and 29 (32.6%) were unwilling. In the univariate binary logistic regression analysis, age (Odds ratio [OR] = 1.84, 95% confidence interval [CI] 1.10-3.09, p = 0.02), psychiatrist (OR = 5.88, 95% CI 2.15-16.08, p = 0.001), hospital (OR = 0.10, 95% CI 0.01-0.94, p = 0.04), the number of COVID-19 risk factors in the participant (OR = 2.88, 95% CI 1.46-5.69, p = 0.002), the number of COVID-19 risk factors in the cohabitants (OR = 2.52, 95% CI 1.05-6.01, p = 0.04), COVID-19 epidemic area (OR = 4.37, 95% CI 1.18-16.20, p = 0.03), consultation time during telemedicine (OR = 2.51, 95% CI 1.32-4.76, p = 0.005), workload due to telemedicine (OR = 4.17, 95% CI 2.11-8.24, p < 0.001) were statistically significant. In the multivariate binary logistic regression analysis, workload due to telemedicine (OR = 4.93, 95% CI 1.96-12.35) was independently associated with the unwillingness to continue telemedicine. CONCLUSION: This national-level cross-sectional survey found that workload due to telemedicine among physicians involved in epilepsy care was independently associated with the unwillingness to continue telemedicine.

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  • Causal relationship between stress and sleep quality and the validity of telemedicine during the COVID-19 lockdown. Reviewed International journal

    Naoto Kuroda, Nozomi Akatsu, Keisuke Hatano, Naoki Ikegaya, Kazuto Katsuse, Satoshi Kodama, Yutaro Takayama, Ayataka Fujimoto

    Epilepsy & behavior : E&B   126   108481 - 108481   2021.12

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  • Sevoflurane-based enhancement of phase-amplitude coupling and localization of the epileptogenic zone. Reviewed International journal

    Keiko Wada, Masaki Sonoda, Ethan Firestone, Kazuki Sakakura, Naoto Kuroda, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Takahiro Mihara, Takahisa Goto, Eishi Asano, Tomoyuki Miyazaki

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology   134   1 - 8   2021.12

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    DOI： 10.1016/j.clinph.2021.11.004

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  • Risk factors for psychological distress in electroencephalography technicians during the COVID-19 pandemic: A national-level cross-sectional survey in Japan Reviewed

    Naoto Kuroda, Takafumi Kubota, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Daichi Sone, Yutaro Takayama, Izumi Kuramochi, Kousuke Kanemoto, Akio Ikeda, Kiyohito Terada, Hiroko Goji, Shinji Ohara, Koichi Hagiwara, Takashi Kamada, Koji Iida, Nobutsune Ishikawa, Hideaki Shiraishi, Osato Iwata, Hidenori Sugano, Yasushi Iimura, Takuichiro Higashi, Hiroshi Hosoyama, Ryosuke Hanaya, Akihiro Shimotake, Takayuki Kikuchi, Takeshi Yoshida, Hiroshi Shigeto, Jun Yokoyama, Takahiko Mukaino, Masaaki Kato, Masanori Sekimoto, Masahiro Mizobuchi, Yoko Aburakawa, Masaki Iwasaki, Eiji Nakagawa, Tomohiro Iwata, Kentaro Tokumoto, Takuji Nishida, Yukitoshi Takahashi, Kenjiro Kikuchi, Ryuki Matsuura, Shin-ichiro Hamano, Hideo Yamanouchi, Satsuki Watanabe, Ayataka Fujimoto, Hideo Enoki, Kyoichi Tomoto, Masako Watanabe, Youji Takubo, Toshihiko Fukuchi, Hidetoshi Nakamoto, Yuichi Kubota, Naoto Kunii, Yuichiro Shirota, Eiichi Ishikawa, Nobukazu Nakasato, Taketoshi Maehara, Motoki Inaji, Shunsuke Takagi, Takashi Enokizono, Yosuke Masuda, Takahiro Hayashi

    Epilepsy & Behavior   125   108361 - 108361   2021.12

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    Objective: To identify the risk factors for psychological distress in electroencephalography (EEG) technicians during the coronavirus disease 2019 (COVID-19) pandemic. Method: In this national-level cross-sectional survey initiated by Japan Young Epilepsy Section (YES Japan), a questionnaire was administered to 173 technicians engaged in EEG at four clinics specializing in epilepsy care and 20 hospitals accredited as (quasi-) epilepsy centers or epilepsy training facilities in Japan from March 1 to April 30, 2021. We collected data on participants' profiles, information about work, and psychological distress outcome measurements, such as the K-6 and Tokyo Metropolitan Distress Scale for Pandemic (TMDP). Linear regression analysis was used to identify the risk factors for psychological distress. Factors that were significantly associated with psychological distress in the univariate analysis were subjected to multivariate analysis. Results: Among the 142 respondents (response rate: 82%), 128 were included in the final analysis. As many as 35.2% of EEG technicians have been under psychological distress. In multivariate linear regression analysis for K-6, female sex, examination for patients (suspected) with COVID-19, and change in salary or bonus were independent associated factors for psychological distress. Contrastingly, in multivariate linear regression analysis for TMDP, female sex, presence of cohabitants who had to be separated from the respondent due to this pandemic, and change in salary or bonus were independent associated factors for psychological distress. Conclusion: We successfully identified the risk factors associated with psychological distress in EEG technicians during the COVID-19 pandemic. Our results may help in understanding the psychological stress in EEG technicians during the COVID-19 pandemic and improving the work environment, which is necessary to maintain the mental health of EEG technicians. (c) 2021 Elsevier Inc. All rights reserved.

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  • Risk factors for psychological distress in electroencephalography technicians during the COVID-19 pandemic: A national-level cross-sectional survey in Japan. Reviewed International journal

    Naoto Kuroda, Takafumi Kubota, Toru Horinouchi, Naoki Ikegaya, Yu Kitazawa, Satoshi Kodama, Teppei Matsubara, Naoto Nagino, Shuichiro Neshige, Temma Soga, Daichi Sone, Yutaro Takayama, Izumi Kuramochi

    Epilepsy & behavior : E&B   125   108361 - 108361   2021.10

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    OBJECTIVE: To identify the risk factors for psychological distress in electroencephalography (EEG) technicians during the coronavirus disease 2019 (COVID-19) pandemic. METHOD: In this national-level cross-sectional survey initiated by Japan Young Epilepsy Section (YES-Japan), a questionnaire was administered to 173 technicians engaged in EEG at four clinics specializing in epilepsy care and 20 hospitals accredited as (quasi-) epilepsy centers or epilepsy training facilities in Japan from March 1 to April 30, 2021. We collected data on participants' profiles, information about work, and psychological distress outcome measurements, such as the K-6 and Tokyo Metropolitan Distress Scale for Pandemic (TMDP). Linear regression analysis was used to identify the risk factors for psychological distress. Factors that were significantly associated with psychological distress in the univariate analysis were subjected to multivariate analysis. RESULTS: Among the 142 respondents (response rate: 82%), 128 were included in the final analysis. As many as 35.2% of EEG technicians have been under psychological distress. In multivariate linear regression analysis for K-6, female sex, examination for patients (suspected) with COVID-19, and change in salary or bonus were independent associated factors for psychological distress. Contrastingly, in multivariate linear regression analysis for TMDP, female sex, presence of cohabitants who had to be separated from the respondent due to this pandemic, and change in salary or bonus were independent associated factors for psychological distress. CONCLUSION: We successfully identified the risk factors associated with psychological distress in EEG technicians during the COVID-19 pandemic. Our results may help in understanding the psychological stress in EEG technicians during the COVID-19 pandemic and improving the work environment, which is necessary to maintain the mental health of EEG technicians.

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  • コロナ禍が日本のてんかん診療に与えた影響 Young Epilepsy Section主導による全国規模の多施設共同調査研究

    黒田 直生人, 久保田 隆文, 堀之内 徹, 池谷 直樹, 北澤 悠, 小玉 聡, 倉持 泉, 松原 鉄平, 梛野 尚人, 音成 秀一郎, 曽我 天馬, 高山 裕太郎, 曽根 大地

    臨床神経生理学   49 ( 5 )   425 - 425   2021.10

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  • コロナ禍・災害時の臨床神経生理学 コロナ禍における脳波検査技師の精神的ストレス要因の同定 Young Epilepsy Section(YES)主導による全国規模の多施設共同調査研究

    黒田 直生人, 久保田 隆文, 堀之内 徹, 北澤 悠, 小玉 聡, 松原 鉄平, 梛野 尚人, 音成 秀一郎, 曽我 天馬, 曽根 大地, 高山 裕太郎, 倉持 泉

    臨床神経生理学   49 ( 5 )   347 - 347   2021.10

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  • コロナ禍が日本のてんかん診療に与えた影響 Young Epilepsy Section主導による全国規模の多施設共同調査研究

    黒田 直生人, 久保田 隆文, 堀之内 徹, 池谷 直樹, 北澤 悠, 小玉 聡, 倉持 泉, 松原 鉄平, 梛野 尚人, 音成 秀一郎, 曽我 天馬, 高山 裕太郎, 曽根 大地

    臨床神経生理学   49 ( 5 )   425 - 425   2021.10

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  • コロナ禍・災害時の臨床神経生理学 コロナ禍における脳波検査技師の精神的ストレス要因の同定 Young Epilepsy Section(YES)主導による全国規模の多施設共同調査研究

    黒田 直生人, 久保田 隆文, 堀之内 徹, 北澤 悠, 小玉 聡, 松原 鉄平, 梛野 尚人, 音成 秀一郎, 曽我 天馬, 曽根 大地, 高山 裕太郎, 倉持 泉

    臨床神経生理学   49 ( 5 )   347 - 347   2021.10

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  • Single-subject gray matter networks in temporal lobe epilepsy patients with hippocampal sclerosis. Reviewed International journal

    Yoko Shigemoto, Noriko Sato, Daichi Sone, Norihide Maikusa, Tensho Yamao, Yukio Kimura, Emiko Chiba, Fumio Suzuki, Hiroyuki Fujii, Yutaro Takayama, Masaki Iwasaki, Eiji Nakagawa, Hiroshi Matsuda

    Epilepsy research   177   106766 - 106766   2021.9

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    OBJECTIVE: Previous studies have demonstrated structural brain network abnormalities in patients with temporal lobe epilepsy (TLE) using cortical thickness or gray matter (GM) volume. However, no studies have applied single-subject GM network analysis. Here, we first applied an analysis of similarity-based single-subject GM networks to individual patients with TLE. MATERIALS AND METHODS: We recruited 51 patients with TLE and unilateral hippocampal sclerosis (22 left, 29 right TLE) and 51 age- and gender- matched healthy controls. Single-subject structural networks were extracted from three-dimensional T1-weighted magnetic resonance images for each subject. In this method, nodes were defined as small cortical regions and edges representing connecting regions that have high statistical similarity. The constructed graphs were analyzed using the graph theoretical approach. The following global and local network properties were calculated: betweenness centrality, clustering coefficient, and characteristic path length. In addition, small world properties (normalized path length λ, normalized clustering coefficient γ, and small-world network value σ) were obtained and compared with those for the controls. RESULTS: Although the small-world configurations were retained, impaired global clustering coefficient was observed in left and right TLE. At a regional level, patients with left TLE showed a widespread decrease of the clustering coefficient beyond the ipsilateral temporal lobe and a decreased characteristic path length in the ipsilateral temporal pole. On the other hand, patients with right TLE showed a localized decrease of the clustering coefficient in the ipsilateral temporal lobe. CONCLUSIONS: Our findings suggest that global and local network properties disrupted and moved toward randomized networks in TLE patients in comparison to controls. This network alteration was more extensive in left TLE than in right TLE patients. Single-subject GM networks may contribute to a better understanding of the pathophysiology of TLE.

    DOI： 10.1016/j.eplepsyres.2021.106766

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  • Epilepsy surgery in children under 3 years of age: surgical and developmental outcomes. Reviewed International journal

    Masaki Iwasaki, Keiya Iijima, Takahiro Kawashima, Hisateru Tachimori, Yutaro Takayama, Yuiko Kimura, Yuu Kaneko, Naoki Ikegaya, Noriko Sumitomo, Takashi Saito, Eiji Nakagawa, Akio Takahashi, Kenji Sugai, Taisuke Otsuki

    Journal of neurosurgery. Pediatrics   28 ( 4 )   1 - 9   2021.8

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    OBJECTIVE: Pediatric epilepsy surgery is known to be effective, but early surgery in infancy is not well characterized. Extensive cortical dysplasia, such as hemimegalencephaly, can cause refractory epilepsy shortly after birth, and early surgical intervention is indicated. However, the complication rate of early pediatric surgery is significant. In this study, the authors assessed the risk-benefit balance of early pediatric epilepsy surgery as relates to developmental outcomes. METHODS: This is a retrospective descriptive study of 75 patients who underwent their first curative epilepsy surgery at an age under 3 years at the authors' institution between 2006 and 2019 and had a minimum 1-year follow-up of seizure and developmental outcomes. Clinical information including surgical complications, seizure outcomes, and developmental quotient (DQ) was collected from medical records. The effects of clinical factors on DQ at 1 year after surgery were evaluated. RESULTS: The median age at surgery was 6 months, peaking at between 3 and 4 months. Operative procedures included 27 cases of hemispherotomy, 19 cases of multilobar surgery, and 29 cases of unilobar surgery. Seizure freedom was achieved in 82.7% of patients at 1 year and in 71.0% of patients at a mean follow-up of 62.8 months. The number of antiseizure medications (ASMs) decreased significantly after surgery, and 19 patients (30.6%) had discontinued their ASMs by the last follow-up. Postoperative complications requiring cerebrospinal fluid (CSF) diversion surgery, such as hydrocephalus and cyst formation, were observed in 13 patients (17.3%). The mean DQ values were 74.2 ± 34.3 preoperatively, 60.3 ± 23.3 at 1 year after surgery, and 53.4 ± 25.1 at the last follow-up. Multiple regression analysis revealed that the 1-year postoperative DQ was significantly influenced by preoperative DQ and postoperative seizure freedom but not by the occurrence of any surgical complication requiring CSF diversion surgery. CONCLUSIONS: Early pediatric epilepsy surgery has an acceptable risk-benefit balance. Seizure control after surgery is important for postoperative development.

    DOI： 10.3171/2021.4.PEDS21123

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  • COVID-19とてんかん 本邦のてんかん診療にCOVID-19がもたらした影響 全国多施設調査

    梛野 尚人, 堀之内 徹, 池谷 直樹, 北澤 悠, 小玉 聡, 久保田 隆文, 倉持 泉, 黒田 直生人, 松原 鉄平, 音成 秀一郎, 曽我 天馬, 曽根 大地, 高山 裕太郎

    てんかん研究   39 ( 2 )   195 - 195   2021.7

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  • Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners. Reviewed International journal

    Hirotaka Iwaki, Masaki Sonoda, Shin-Ichiro Osawa, Brian H Silverstein, Takumi Mitsuhashi, Kazushi Ukishiro, Yutaro Takayama, Toshimune Kambara, Kazuo Kakinuma, Kyoko Suzuki, Teiji Tominaga, Nobukazu Nakasato, Masaki Iwasaki, Eishi Asano

    Scientific reports   11 ( 1 )   5257 - 5257   2021.3

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    The left prefrontal cortex is essential for verbal communication. It remains uncertain at what timing, to what extent, and what type of phrase initiates left-hemispheric dominant prefrontal activation during comprehension of spoken sentences. We clarified this issue by measuring event-related high-gamma activity during a task to respond to three-phrase questions configured in different orders. Questions beginning with a wh-interrogative deactivated the left posterior prefrontal cortex right after the 1st phrase offset and the anterior prefrontal cortex after the 2nd phrase offset. Left prefrontal high-gamma activity augmented subsequently and maximized around the 3rd phrase offset. Conversely, questions starting with a concrete phrase deactivated the right orbitofrontal region and then activated the left posterior prefrontal cortex after the 1st phrase offset. Regardless of sentence types, high-gamma activity emerged earlier, by one phrase, in the left posterior prefrontal than anterior prefrontal region. Sentences beginning with a wh-interrogative may initially deactivate the left prefrontal cortex to prioritize the bottom-up processing of upcoming auditory information. A concrete phrase may obliterate the inhibitory function of the right orbitofrontal region and facilitate top-down lexical prediction by the left prefrontal cortex. The left anterior prefrontal regions may be recruited for semantic integration of multiple concrete phrases.

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  • Single-Institutional Experience of Chronic Intracranial Electroencephalography Based on the Combined Usage of Subdural and Depth Electrodes. Reviewed International journal

    Yutaro Takayama, Naoki Ikegaya, Keiya Iijima, Yuiko Kimura, Suguru Yokosako, Norihiro Muraoka, Kenzo Kosugi, Yuu Kaneko, Tetsuya Yamamoto, Masaki Iwasaki

    Brain sciences   11 ( 3 )   2021.2

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    Implantation of subdural electrodes on the brain surface is still widely performed as one of the "gold standard methods" for the presurgical evaluation of epilepsy. Stereotactic insertion of depth electrodes to the brain can be added to detect brain activities in deep-seated lesions to which surface electrodes are insensitive. This study tried to clarify the efficacy and limitations of combined implantation of subdural and depth electrodes in intractable epilepsy patients. Fifty-three patients with drug-resistant epilepsy underwent combined implantation of subdural and depth electrodes for long-term intracranial electroencephalography (iEEG) before epilepsy surgery. The detectability of early ictal iEEG change (EIIC) were compared between the subdural and depth electrodes. We also examined clinical factors including resection of MRI lesion and EIIC with seizure freedom. Detectability of EIIC showed no significant difference between subdural and depth electrodes. However, the additional depth electrode was useful for detecting EIIC from apparently deep locations, such as the insula and mesial temporal structures, but not in detecting EIIC in patients with ulegyria (glial scar). Total removal of MRI lesion was associated with seizure freedom. Depth electrodes should be carefully used after consideration of the suspected etiology to avoid injudicious usage.

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  • Deep Brain Stimulation for Refractory Tourette Syndrome: Electrode Position and Clinical Outcome. Reviewed

    Yuiko Kimura, Keiya Iijima, Yutaro Takayama, Suguru Yokosako, Yuu Kaneko, Mayu Omori, Takanobu Kaido, Yukiko Kano, Masaki Iwasaki

    Neurologia medico-chirurgica   61 ( 1 )   33 - 39   2021.1

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    The efficacy of deep brain stimulation (DBS) for refractory Tourette syndrome (TS) is accepted, but whether the efficacy of DBS treatment in the Japanese population is equivalent to those reported internationally and whether adverse effects are comparable are not yet known. This study evaluated the clinical practice and outcome of DBS for TS in a Japanese institution. This study included 25 consecutive patients with refractory TS treated with thalamic centromedian-parafascicular nucleus DBS. The severity of tics was evaluated with the Yale Global Tic Severity Scale (YGTSS) before surgery, at 1 year after surgery, and at the last follow-up of 3 years or more after surgery. The occurrence of adverse events, active contact locations, and stimulation conditions were also evaluated. YGTSS tic severity score decreased by average 45.2% at 1 year, and by 56.6% at the last follow-up. The reduction was significant for all aspects of the scores including motor tics, phonic tics, and impairment. The mean coordinates of active contacts were 7.62 mm lateral to the midline, 3.28 mm posterior to the midcommissural point, and 3.41 mm above anterior commissure-posterior commissure plane. Efficacy and stimulation conditions were equivalent to international reports. The stimulation-induced side effects included dysarthria (32.0%) and paresthesia (12.0%). Device infection occurred in three patients (12.0%) as a surgical complication. The DBS device was removed because of infection in two patients. DBS is an effective treatment for refractory TS, although careful indication is necessary because of the surgical risks and unknown long-term outcome.

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  • Corpus callosotomy in pediatric patients with non-lesional epileptic encephalopathy with electrical status epilepticus during sleep. Reviewed International journal

    Suguru Yokosako, Norihiro Muraoka, Shiena Watanabe, Kenzo Kosugi, Yutaro Takayama, Keiya Iijima, Yuiko Kimura, Yu Kaneko, Noriko Sumitomo, Takashi Saito, Eiji Nakagawa, Masaki Iwasaki

    Epilepsy & behavior reports   16   100463 - 100463   2021

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    Epileptic encephalopathy with electrical status epilepticus during sleep (ESES) is often refractory to medical treatment and leads to poor cognitive outcomes. Corpus callosotomy may be an effective treatment option for drug-resistant ESES with no focal etiology. We retrospectively identified three patients who underwent corpus callosotomy for drug-resistant ESES in our institution. Electroencephalography (EEG) findings and cognitive functions were evaluated before surgery, at 3 months, 6 months, 1 year, and 2 years after surgery. Age at surgery was 6 years 10 months, 7 years 9 months, and 8 years 4 months, respectively. Period between the diagnosis of ESES and surgery ranged from 7 to 25 months. All patients had no obvious structural abnormalities and presented with cognitive decline despite multiple antiseizure medications and steroid therapies. One patient showed complete resolution of ESES and an improvement of intelligence quotient after surgery. Epileptiform EEG was lateralized to one hemisphere after surgery and spike wave index (SWI) was decreased with moderate improvement in development and seizures in the other 2 patients. SWI re-exacerbated from 6 months after surgery, but without subsequent developmental regression in these 2 patients. Corpus callosotomy may become an important treatment option for drug-resistant ESES in patients with no structural abnormalities.

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  • てんかん外科における脳機能モニタリング 頭蓋内脳波による言語機能解析

    岩崎 真樹, 池谷 直樹, 高山 裕太郎, 飯島 圭哉, 浅野 英司

    臨床神経生理学   48 ( 5 )   403 - 403   2020.10

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  • 硬膜下・深部電極を併用した慢性頭蓋内脳波記録の有効性と限界

    高山 裕太郎, 池谷 直樹, 飯島 圭哉, 木村 唯子, 横佐古 卓, 小杉 健三, 金子 裕, 岩崎 真樹

    臨床神経生理学   48 ( 5 )   534 - 534   2020.10

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  • てんかん外科と神経生理学の融合 わが国におけるSEEGの現状と将来

    岩崎 真樹, 高山 裕太郎, 飯島 圭哉, 木村 唯子, 金子 裕

    臨床神経生理学   48 ( 5 )   475 - 475   2020.10

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  • 国際・国内レベルでの若手てんかん従事者ネットワーク Young Epilepsy Sectionの取り組み

    曾根 大地, 飯島 圭哉, 池谷 直樹, 北澤 悠, 倉持 泉, 黒田 直生人, 曽我 天馬, 高山 裕太郎, 堀之内 徹, 松原 鉄平

    精神神経学雑誌   ( 2020特別号 )   S564 - S564   2020.9

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  • てんかんの外科治療

    岩崎 真樹, 飯島 圭哉, 高山 裕太郎, 木村 唯子, 金子 裕, 住友 典子, 齋藤 貴志, 中川 栄二, 佐々木 征行

    脳と発達   52 ( Suppl. )   S74 - S74   2020.8

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  • Spatiotemporal dynamics of auditory and picture naming-related high-gamma modulations: A study of Japanese-speaking patients. Reviewed International journal

    Naoki Ikegaya, Hirotaka Motoi, Keiya Iijima, Yutaro Takayama, Toshimune Kambara, Ayaka Sugiura, Brian H Silverstein, Masaki Iwasaki, Eishi Asano

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology   130 ( 8 )   1446 - 1454   2019.8

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    OBJECTIVE: To characterize the spatiotemporal dynamics of auditory and picture naming-related cortical activation in Japanese-speaking patients. METHODS: Ten patients were assigned auditory naming and picture naming tasks during extraoperative intracranial EEG recording in a tertiary epilepsy center. Time-frequency analysis determined at what electrode sites and at what time windows during each task the amplitude of high-gamma activity (65-95 Hz) was modulated. RESULTS: The superior-temporal gyrus on each hemisphere showed high-gamma augmentation during sentence listening, whereas the left middle-temporal and inferior-frontal gyri showed high-gamma augmentation peaking around stimulus offset. Auditory naming-specific high-gamma augmentation was noted in the bilateral superior-temporal gyri as well as left frontal-parietal-temporal perisylvian network regions, whereas picture naming-specific augmentation was noted in the occipital-fusiform regions, bilaterally. The inferior pre- and postcentral gyri on each hemisphere showed modality-common high-gamma augmentation time-locked to overt responses. CONCLUSIONS: The spatiotemporal dynamics of auditory and picture naming-related high-gamma augmentation in Japanese-speaking patients were qualitatively similar to those previously reported in studies of English-speaking patients. SIGNIFICANCE: The cortical dynamics for auditory sentence recognition are at least partly shared by cohorts speaking two distinct languages. Multicenter studies regarding the clinical utility of high-gamma language mapping across Eastern and Western hemispheres may be feasible.

    DOI： 10.1016/j.clinph.2019.04.008

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  • Radiologic and Pathologic Features of the Transmantle Sign in Focal Cortical Dysplasia: The T1 Signal Is Useful for Differentiating Subtypes

    Yukio Kimura, A. Shioya, Y. Saito, Y. Oitani, Y. Shigemoto, E. Morimoto, F. Suzuki, N. Ikegaya, Yuiko Kimura, K. Iijima, Y. Takayama, M. Iwasaki, M. Sasaki, N. Sato

    American Journal of Neuroradiology   40 ( 6 )   1060 - 1066   2019.6

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    DOI： 10.3174/ajnr.a6067

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  • [(1)Indication for Invasive Monitoring in the Surgical Treatment of Epilepsy]. Reviewed

    Masaki Iwasaki, Yutaro Takayama, Keiya Iijima, Yuiko Kimura, Norihiro Muraoka, Yuu Kaneko

    No shinkei geka. Neurological surgery   47 ( 1 )   5 - 14   2019.1

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    DOI： 10.11477/mf.1436203890

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  • Current and future perspectives of epilepsy surgery in Japan

    Masaki Iwasaki, Keiya Iijima, Yutaro Takayama, Yuiko Kimura, Yuu Kaneko

    Japanese Journal of Neurosurgery   28 ( 6 )   326 - 333   2019

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Congress of Neurological Surgeons  

    DOI： 10.7887/jcns.28.326

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  • Surgical treatment of intractable epilepsy presenting with hyperkinetic seizures originating in the frontal lobe

    Osawa, S., Iwasaki, M., Takayama, Y., Jin, K., Nakasato, N., Tominaga, T.

    Japanese Journal of Neurosurgery   27 ( 10 )   2018

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    DOI： 10.7887/jcns.27.764

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  • コイル塞栓術後に血栓化巨大脳動脈瘤となった脳底動脈先端部脳動脈瘤の1例 Reviewed

    間中 浩, 坂田 勝巳, 篠原 禎雄, 高山 裕太郎, 川崎 隆

    脳卒中の外科   42 ( 5 )   372 - 376   2014.9

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    59歳男。両側動眼神経麻痺、体幹失調を主訴とした。約5年前に脳底動脈先端部(BA-tip)脳動脈瘤に対して瘤内塞栓術が行われたが、術中のトラブルもあり不十分なコイル充填で手術を終了していた。MRIではmixed intensityを呈する腫瘤が中脳を背側に圧排して脳室拡大を呈しており、巨大血栓化BA-tip動脈瘤とそれによる閉塞性水頭症と診断された。水頭症に対して脳室腹腔シャント術が施行された後、脳動脈瘤の再治療目的で転院となり、脳動脈瘤塞栓支援ステントを用いて瘤内を可及的密に塞栓した。約2年の経過において症状の増悪や画像所見の悪化を認めず、MRI所見上mass effectは軽減したものの、瘤壁の増強効果と瘤周囲の浮腫を疑わせる所見を認めることから、今後も慎重な経過観察が必要である。

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    Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J02079&link_issn=&doc_id=20141003270009&doc_link_id=%2Fcp4strok%2F2014%2F004205%2F009%2F0372-0376%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp4strok%2F2014%2F004205%2F009%2F0372-0376%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 高齢者で発症した毛様類粘液性細胞腫 1症例報告(Pilomyxoid astrocytoma arising elder age: A case report) Reviewed

    池谷 直樹, 佐藤 秀光, 高山 裕太郎, 三宅 勇平, 立石 健祐, 村田 英俊, 山中 正二, 川原 信隆

    Brain Tumor Pathology   30 ( Suppl. )   132 - 132   2013.5

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  • Lesion-Guided Radiofrequency Thermocoagulation for Epileptogenic Lesions Near the Arcuate Fasciculus: A Technical Note of Minimally Invasive Strategy for Bottom-of-Sulcus Epilepsy

    高山裕太郎, 高山裕太郎, 林貴啓, 林貴啓, 木村唯子, 飯島圭哉, 園田真樹, 池谷直樹, 川崎隆, 川崎隆, 東島威史, 東島威史, 山本哲哉, 岩崎真樹

    てんかん研究   43 ( 2 )   2025

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  • ロボットアームを用いた頭蓋内電極留置術

    高山裕太郎, 山本哲哉

    日本ロボット外科学会学術集会プログラム・抄録集   16th   2024

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  • 島-弁蓋部てんかんに対するvolume-based radiofrequency-thermocoagulation(Volume-based radiofrequency-thermocoagulation for insulo-opercular epilepsy)

    高山 裕太郎, 木村 唯子, 飯島 圭哉, 吉富 宗健, 小杉 健三, 山本 哲哉, 岩崎 真樹

    てんかん研究   41 ( 2 )   355 - 355   2023.9

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  • てんかん外科治療up-to-date-最新のてんかん原性領域診断とQOLを考慮した治療について- 小児の島・弁蓋部てんかんに対するラジオ波温熱凝固術

    高山 裕太郎, 木村 唯子, 飯島 圭哉, 小杉 健三, 吉富 宗健, 住友 典子, 馬場 信平, 本橋 裕子, 竹下 絵里, 齋藤 貴志, 中川 栄二, 山本 哲哉, 岩崎 真樹

    脳と発達   55 ( Suppl. )   S136 - S136   2023.5

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  • 硬膜下・深部電極を併用した頭蓋内電極留置術の有効性と限界

    高山 裕太郎, 池谷 直樹, 飯島 圭哉, 横佐古 卓, 小杉 健三, 木村 唯子, 金子 裕, 岩崎 真樹

    小児の脳神経   46 ( 2 )   193 - 193   2021.4

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  • Is hippocampal resection necessary for seizure freedom in patients of temporal LEAT?

    高山裕太郎, 池谷直樹, 飯島圭哉, 横佐古卓, 小杉健三, 木村唯子, 金子裕, 岩崎真樹

    てんかん研究   39 ( 2 )   425 - 425   2021

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  • 小児難治てんかんの外科治療とチーム診療体制 瘢痕回に伴う難治性てんかん患者に対する焦点切除において頭蓋内脳波記録は有用か?

    高山 裕太郎, 横佐古 卓, 岩崎 真樹

    小児の脳神経   45 ( 3 )   232 - 232   2020.10

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  • 硬膜下・深部電極を併用した慢性頭蓋内脳波記録の有効性と限界

    高山 裕太郎, 池谷 直樹, 飯島 圭哉, 木村 唯子, 横佐古 卓, 小杉 健三, 金子 裕, 岩崎 真樹

    臨床神経生理学   48 ( 5 )   534 - 534   2020.10

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  • 国際・国内レベルでの若手てんかん従事者ネットワーク Young Epilepsy Sectionの取り組み

    曾根 大地, 飯島 圭哉, 池谷 直樹, 北澤 悠, 倉持 泉, 黒田 直生人, 曽我 天馬, 高山 裕太郎, 堀之内 徹, 松原 鉄平

    精神神経学雑誌   ( 2020特別号 )   S564 - S564   2020.9

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  • 合格したての先輩が指南する 脳神経外科専門医への道＼専門医を目指す君に/Q&A+詳細解説でわかる脳神経外科疾患ベーシック てんかん外科 皮質形成異常

    高山 裕太郎

    脳神経外科速報   30 ( 8 )   874 - 878   2020.8

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  • 【専門医なら知っておきたい 疾患・術式別 脳神経外科手術合併症の回避・対処法 Q&A 156】(10章)機能的脳神経外科手術 てんかん外科手術 硬膜下電極留置術に伴う合併症の予防法は?

    高山 裕太郎, 岩崎 真樹

    脳神経外科速報   ( 2019増刊 )   274 - 275   2019.10

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  • 【専門医なら知っておきたい 疾患・術式別 脳神経外科手術合併症の回避・対処法 Q&A 156】(10章)機能的脳神経外科手術 てんかん外科手術 深部電極留置術に伴う合併症の予防法は?

    高山 裕太郎, 岩崎 真樹

    脳神経外科速報   ( 2019増刊 )   280 - 280   2019.10

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  • 硬膜下電極留置術における適切な深部電極併用方法の検討

    高山 裕太郎, 飯島 圭哉, 村岡 範裕, 横佐古 卓, 木村 唯子, 金子 裕, 池谷 直樹, 岩崎 真樹

    てんかん研究   37 ( 2 )   558 - 558   2019.9

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  • 小児期神経膠腫治療後の難治性てんかんに対し焦点切除術を施行した1例

    高山 裕太郎, 飯島 圭哉, 池谷 直樹, 木村 唯子, 村岡 範裕, 金子 裕, 岩崎 真樹

    てんかん研究   36 ( 3 )   704 - 705   2019.1

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  • 発作時に無関心を思わせる態度を示した右前頭葉てんかんの1例

    高山 裕太郎, 柿坂 庸介, 神 一敬, 北澤 悠, 上利 大, 藤川 真由, 菅野 彰剛, 西尾 慶之, 中里 信和

    てんかん研究   35 ( 3 )   741 - 742   2018.1

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  • よく使う日常治療薬の正しい使い方 成人てんかんに対する抗てんかん薬の正しい使い方

    高山 裕太郎, 柿坂 庸介, 中里 信和

    レジデントノート   19 ( 12 )   2169 - 2172   2017.11

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  • 胚芽異形成性神経上皮腫瘍(DNT)と神経節膠腫における脳磁図所見の観察

    高山 裕太郎, 神 一敬, 柿坂 庸介, 菅野 彰剛, 岩崎 真樹, 石田 誠, 大沢 伸一郎, 北澤 悠, 上利 大, 中里 信和

    てんかん研究   35 ( 2 )   452 - 452   2017.9

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  • Clarifying the Principles and Practices of Epilepsy Surgery Using Elements and Cirq-SEEG.

    園田真樹, 園田真樹, 高山裕太郎, 高山裕太郎, 池谷直樹, 池谷直樹, 山本哲哉, 山本哲哉

    日本てんかん外科学会プログラム・抄録集   48th   2025

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  • Association of anti-epileptic drugs and degenerative dementia

    池谷直樹, 池谷直樹, 中村ほのか, 高山裕太郎, 高山裕太郎, 林貴啓, 林貴啓, 園田真樹, 園田真樹, 高石政男, 高石政男, 北澤悠, 北澤悠, 國井美紗子, 國井美紗子, 阿部弘基, 宮崎智之, 新井哲明, 岩崎学, 岩崎学, 阿部貴行, 阿部貴行, 山本哲哉, 山本哲哉

    てんかん研究   43 ( 2 )   2025

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  • Indications for Stereotactic Thermocoagulation in Focal Cortical Dysplasia with a Focus on Reducing Deep White Matter Infarction Risk

    林貴啓, 林貴啓, 飯島圭哉, 岡崎洋介, 木村唯子, 高山裕太郎, 佐藤典子, 木村有喜男, 加賀谷理紗, 岩崎真樹

    てんかん研究   43 ( 2 )   2025

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  • がんゲノム遺伝子パネル検査とin house遺伝子解析の組み合わせから見えた神経膠腫の特徴

    立石健祐, 立石健祐, 矢澤理, 矢澤理, 高山裕太郎, 高山裕太郎, 加藤真吾, 大島聡人, 大島聡人, 加藤三結, 山中正二, 藤井誠志, 山本哲哉

    Brain Tumor Pathology. Supplement   42   2025

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  • Analysis of Clinical Outcomes and Future Challenges of Epilepsy Care at YCU Epilepsy Center: Toward Effective Hospital-Community Collaboration

    園田真樹, 園田真樹, 池谷直樹, 池谷直樹, 高山裕太郎, 高山裕太郎, 武田むつき, 武田むつき, 北澤悠, 北澤悠, 高石政男, 高石政男, 山本哲哉, 山本哲哉

    てんかん研究   43 ( 2 )   2025

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  • Defensive resting thalamocortical networks involving non-epileptic brain regions regulate consciousness in focal epilepsy

    高山裕太郎, 高山裕太郎, MITHANI Karim, 上原一将, 本田純也, 本田純也, 北城圭一, 岩崎真樹, 山本哲哉, OCHI Ayako, OTSUBO Hiroshi, IBRAHIM George

    てんかん研究   43 ( 2 )   2025

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  • Cirqロボットアームシステムを用いたSEEGの精度検証

    毛呂 貴宏, 園田 真樹, 高山 裕太郎, 池谷 直樹, 東島 威史, 山本 哲哉

    臨床神経生理学   52 ( 5 )   561 - 561   2024.10

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  • The utility and challenges of Stereotactic EEG electrode placement using the Cirq robotic system

    園田真樹, 高山裕太郎, 東島威史, 池谷直樹, 山田祐希, 山本哲哉

    てんかん研究   42 ( 2 )   513 - 513   2024.9

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  • Clinical and molecular characteristics of IDH-mutant gliomas in aged patients

    矢澤理, 立石健祐, 立石健祐, 三宅勇平, 高山裕太郎, 園田真樹, 池谷直樹, 岡千紘, 大島聡人, 本間博邦, 山本哲哉

    日本脳腫瘍学会学術集会プログラム・抄録集   42nd   2024

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  • Stereotactic radio-frequency thermocoagulation for drug-resistant focal epilepsy: initial experience

    岩崎真樹, 飯島圭哉, 高山裕太郎, 木村唯子, 林貴啓, 金子裕

    日本てんかん外科学会プログラム・抄録集   47th   2024

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  • てんかん原性領域として同側海馬も示唆されたPolymorphous low-grade neuroepithelial tumor of the young(PLNTY)に伴う難治側頭葉てんかんの1例

    毛呂貴宏, 園田真樹, 園田真樹, 高山裕太郎, 高山裕太郎, 岩下広道, 山中生二, 藤井誠志, 立石健祐, 山本哲哉, 山本哲哉

    臨床神経生理学(Web)   52 ( 5 )   2024

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  • Cirqロボットアームシステムを用いたSEEGの精度検証

    毛呂貴宏, 園田真樹, 高山裕太郎, 池谷直樹, 東島威史, 山本哲哉

    臨床神経生理学(Web)   52 ( 5 )   2024

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  • A case of polymorphous low-grade neuroepithelial tumor of the young (PLNTY) suspected with malignant transformation

    八重樫茉莉子, 立石健祐, 高山裕太郎, 園田真樹, 石山貴博, 林弘明, 大島聡人, 山中正二, 藤井誠志, 藤井誠志, 山本哲哉

    日本脳腫瘍学会学術集会プログラム・抄録集   42nd   2024

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  • Significance of DNA copy number alterations using glioma patient-derived xenograft models

    大島聡人, 加藤三結, 葉偉凱, 岡千紘, 矢澤理, 高山裕太郎, 三宅勇平, 園田真樹, 山本哲哉, 立石健祐, 立石健祐

    日本脳腫瘍学会学術集会プログラム・抄録集   42nd   2024

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  • 小児の島回てんかん3例の発作徴候とSEEGによる検討

    相原 悠, 馬場 信平, 飯島 圭哉, 木村 唯子, 高山 裕太郎, 本橋 裕子, 齋藤 貴志, 中川 栄二, 岩崎 真樹

    てんかん研究   41 ( 2 )   341 - 341   2023.9

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  • Stereotactic encephalography using Cirq robotic arm; Tips and Pitfalls

    池谷直樹, 高山裕太郎

    てんかん研究   41 ( 2 )   290 - 290   2023.9

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  • 小児の皮質形成異常に対するラジオ周波温熱凝固術

    岩崎 真樹, 高山 裕太郎, 飯島 圭哉, 木村 唯子, 吉富 宗健, 金子 裕, 住友 典子, 馬場 信平, 齋藤 貴志, 中川 栄二

    小児の脳神経   48 ( 2 )   197 - 197   2023.4

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  • Stereotactic thermocoagulation for the treatment of epilepsy

    岩崎真樹, 高山裕太郎, 飯島圭哉, 木村唯子, 吉富宗健, 金子裕

    日本てんかん外科学会プログラム・抄録集   62回   55 - 55   2023.1

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  • Trial of the short-time MGMT promoter methylation determination system for gliomas

    杉野杏夏, 杉野杏夏, 林貴啓, 本間博邦, 大島聡人, 林弘明, 高山裕太郎, 園田真樹, 内山夏穂, 加藤三結, 山本哲哉, 立石健祐, 立石健祐

    日本脳腫瘍学会学術集会プログラム・抄録集   41st   2023

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  • Radiofrequency thermocoagulation for pediatric epilepsy with focal cortical dysplasia

    岩崎真樹, 高山裕太郎, 飯島圭哉, 木村唯子, 吉富宗健, 金子裕, 住友典子, 馬場信平, 齋藤貴志, 中川栄二

    小児の脳神経(Web)   48 ( 2 )   2023

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  • Six-dimensional dynamic tractography atlas of language connectivity in the developing brain and its clinical utility

    園田真樹, 高山裕太郎, 林貴啓, 山本哲哉

    小児の脳神経(Web)   48 ( 2 )   2023

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  • Improvement of deep-learning-based epileptic EEG feature detection by data augmentation

    沢田真幸, BROTI Nawara Mahmood, 高山裕太郎, 岩崎真樹, 小野弓絵

    人工知能学会全国大会論文集(Web)   37th   2023

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  • 悪性脳腫瘍に対する臨床と基礎研究の統合プラットフォーム

    立石健祐, 三宅勇平, 本間博邦, 大島聡人, 林貴啓, 高山裕太郎, 園田真樹, 末永潤, 山本哲哉

    日本脳腫瘍の外科学会プログラム・抄録集   28th   2023

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  • Safety, feasibility, and efficacy of additional extraventricular anterior commissurotomy in corpus callosotomy

    小杉健三, 吉富宗健, 高山裕太郎, 飯島圭哉, 木村唯子, 金子裕, 戸田正博, 岩崎真樹

    てんかん研究   40 ( 2 )   437 - 437   2022.8

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  • Surgical treatment of pediatric epilepsy: concepts and practice

    岩崎真樹, 飯島圭哉, 高山裕太郎, 木村唯子, 金子裕, 住友典子, 齋藤貴志, 中川栄二, 佐々木征行

    脳と発達   54 ( 1 )   5 - 10   2022.1

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  • Early epilepsy surgery for infants with drug-resistant epilepsy

    岩崎真樹, 飯島圭哉, 高山裕太郎, 小杉健三, 吉富宗健, 木村唯子, 金子裕, 馬場信平, 住友典子, 齋藤貴志, 中川栄二

    日本てんかん外科学会プログラム・抄録集   45th   2022

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  • Predictors of seizure outcome after repeat pediatric epilepsy surgery

    岩崎真樹, 飯島圭哉, 高山裕太郎, 川島貴大, 立森久照, 木村唯子, 小杉健三, 吉富宗健, 金子裕

    小児の脳神経(Web)   47 ( 2 )   2022

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  • 術中皮質脳波記録が焦点同定に有用であった結節性硬化症の一例

    小杉健三, 飯島圭哉, 吉富宗健, 高山裕太郎, 木村唯子, 金子裕, 岩崎真樹

    てんかん研究   40 ( 1 )   2022

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  • Volume-based radiofrequency-thermocoagulation for insulo-opercular epilepsy

    高山裕太郎, 高山裕太郎, 木村唯子, 飯島圭哉, 横佐古卓, 小杉健三, 吉富宗健, 本橋裕子, 馬場信平, 山本哲哉, 岩崎真樹

    てんかん研究   40 ( 2 )   2022

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  • Treatment strategy of malignant tumor in orbit

    末永潤, 佐藤充, 荒井康裕, 本郷剛, 飯田悠, 松澤良, 高山裕太郎, 三宅勇平, 園田真樹, 池谷直樹, 堀聡, 立石健祐, 清水信行, 折舘伸彦, 山本哲哉

    日本頭蓋底外科学会プログラム・抄録集   34th   2022

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  • Anatomy of intraosseous arteriovenous fistula and transvenous embolization via the venous network of the foramen magnum

    飯田悠, 清水信行, 鈴木良介, 三宅勇平, 高山裕太郎, 園田真樹, 池谷直樹, 堀聡, 佐藤充, 立石健祐, 末永潤, 山本哲哉

    脳血管内治療(Web)   7 ( Supplement )   2022

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  • Experiences of exoscopic surgery for orbital tumor

    末永潤, 誉田紘起, 本郷剛, 松澤良, 高山裕太郎, 三宅勇平, 佐藤充, 堀聡, 立石健祐, 山本哲哉

    日本神経内視鏡学会プログラム・抄録集   29th   2022

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  • Patient-derived models of central nervous system malignant lymphoma and their molecular genetic characteristics

    三宅勇平, 本間博邦, 中村大志, 大島聡人, 林貴啓, 高山裕太郎, 池谷直樹, 山本哲哉, 立石健祐

    日本脳腫瘍学会学術集会プログラム・抄録集   40th   2022

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  • Assessment of rapid diagnostic system for malignant brain tumors

    林貴啓, 立石健祐, 立石健祐, 大島聡人, 本間博邦, 三宅勇平, 池谷直樹, 高山裕太郎, 末永潤, 岩下広道, 山中正二, 藤井誠志, 山本哲哉

    日本脳腫瘍学会学術集会プログラム・抄録集   40th   2022

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  • 大脳半球後半部離断術によっててんかん発作が消失した18番染色体長腕部分欠失モザイク男児例

    神内 済, 井上 絢香, 住友 典子, 齋藤 貴志, 高山 裕太郎, 小林 梢, 北條 彰, 竹下 絵里, 本橋 裕子, 石山 昭彦, 岩崎 真樹, 中川 栄二, 佐々木 征行

    脳と発達   53 ( 4 )   307 - 307   2021.7

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  • 小児に対するFrame固定下でのSEEGの手法と正確性の検討

    横佐古 卓, 小杉 健三, 高山 裕太郎, 飯島 圭哉, 木村 唯子, 住友 典子, 齋藤 貴志, 金子 裕, 中川 栄二, 岩崎 真樹

    てんかん研究   39 ( 2 )   338 - 338   2021.7

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  • 早期乳児てんかん性脳症(大田原症候群)の診療最前線 EIEEで発症したてんかんに対する外科治療 早期手術の是非

    岩崎 真樹, 住友 典子, 飯島 圭哉, 高山 裕太郎, 木村 唯子, 金子 裕, 齋藤 貴志, 中川 栄二

    てんかん研究   39 ( 2 )   198 - 199   2021.7

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  • 【脳神経外科専門医への道:その先を見据えて】領域別解説 てんかん外科

    岩崎 真樹, 飯島 圭哉, 高山 裕太郎

    脳神経外科速報   31 ( 3 )   433 - 437   2021.5

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  • MRI画像を用いた低悪性度てんかん原性神経上皮性腫瘍の遺伝子型予測

    飯島圭哉, 佐藤典子, 小杉健三, 横佐古卓, 高山裕太郎, 木村唯子, 金子裕, 岩崎真樹

    日本脳神経CI学会総会プログラム・抄録集(Web)   44th   2021

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  • EEG gamma entropy and FDG-PET are useful in predicting postoperative seizure outcomes of subsequent surgery after corpus callosotomy

    小杉健三, 飯島圭哉, 横佐古卓, 高山裕太郎, 木村唯子, 金子裕, 岩崎真樹

    てんかん研究   39 ( 2 )   314 - 314   2021

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  • Can MRI be used to predict the genotype in low-grade epilepsy-associated neuroepithelial tumors?

    飯島圭哉, 佐藤典子, 小杉健三, 横佐古卓, 高山裕太郎, 木村唯子, 金子裕, 岩崎真樹

    てんかん研究   39 ( 2 )   209 - 209   2021

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  • Epilepsy surgery for children with a history of early infantile epileptic encephalopathy

    岩崎真樹, 住友典子, 飯島圭哉, 高山裕太郎, 木村唯子, 金子裕, 齋藤貴志, 中川栄二

    てんかん研究   39 ( 2 )   198 - 199   2021

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  • Plan and Accuracy of Frame-Based Stereoelectroencephalography Electrode Placement in Children

    横佐古卓, 小杉健三, 高山裕太郎, 飯島圭哉, 木村唯子, 住友典子, 齋藤貴志, 金子裕, 中川栄二, 岩崎真樹

    てんかん研究   39 ( 2 )   338 - 338   2021

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  • FDG-PET and gamma entropy analysis are useful in predicting postoperative seizure outcomes of subsequent surgery after corpus callosotomy

    小杉健三, 飯島圭哉, 横佐古卓, 高山裕太郎, 木村唯子, 金子裕, 岩崎真樹

    小児の脳神経   46 ( 2 )   195 - 195   2021

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  • 大脳半球後半部離断術によっててんかん発作が消失した18番染色体長腕部分欠失モザイク男児例

    神内済, 井上絢香, 住友典子, 齋藤貴志, 高山裕太郎, 小林梢, 北條彰, 竹下絵里, 本橋裕子, 石山昭彦, 岩崎真樹, 中川栄二, 佐々木征行

    脳と発達   53 ( 4 )   307 - 307   2021

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  • Impact of COVID-19 on epilepsy care in Japan: A nation-wide multi-center survey

    梛野尚人, 堀之内徹, 池谷直樹, 北澤悠, 小玉聡, 久保田隆文, 倉持泉, 黒田直生人, 松原鉄平, 音成秀一郎, 曽我天馬, 曽根大地, 高山裕太郎

    てんかん研究   39 ( 2 )   195 - 195   2021

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  • Genotype-imaging correlation in low-grade epilepsy-associated neuroepithelial tumors

    飯島圭哉, 佐藤典子, 小杉健三, 横佐古卓, 高山裕太郎, 金子裕, 岩崎真樹

    小児の脳神経   46 ( 2 )   184 - 184   2021

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  • Epilepsy surgery : recent knowledge for neurologists

    岩崎真樹, 飯島圭哉, 高山裕太郎, 木村唯子, 金子裕

    神経治療学(Web)   38 ( 4 )   2021

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  • Experience of DBS therapy for Tourette syndrome: Perspective on the expansion of DBS indications in Japan

    木村唯子, 飯島圭哉, 高山裕太郎, 横佐古卓, 小杉健三, 金子裕, 大森まゆ, 金生由紀子, 岩崎真樹

    日本定位・機能神経外科学会プログラム・抄録集(Web)   60回   76 - 76   2020.12

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  • てんかん外科における脳機能モニタリング 頭蓋内脳波による言語機能解析

    岩崎 真樹, 池谷 直樹, 高山 裕太郎, 飯島 圭哉, 浅野 英司

    臨床神経生理学   48 ( 5 )   403 - 403   2020.10

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  • 脳梁離断術後、頭蓋内電極留置術を経てSubtotal hemispherotomyを施行した2例

    横佐古 卓, 高山 裕太郎, 岩崎 真樹

    小児の脳神経   45 ( 3 )   260 - 260   2020.10

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  • てんかん外科と神経生理学の融合 わが国におけるSEEGの現状と将来

    岩崎 真樹, 高山 裕太郎, 飯島 圭哉, 木村 唯子, 金子 裕

    臨床神経生理学   48 ( 5 )   475 - 475   2020.10

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  • てんかん新規治療の動向 神経内科医に知ってほしいてんかん外科治療

    岩崎 真樹, 飯島 圭哉, 高山 裕太郎, 木村 唯子, 金子 裕

    神経治療学   37 ( 6 )   S155 - S155   2020.10

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  • 小児難治てんかんの外科治療とチーム診療体制 乳幼児てんかんの外科治療における発作転帰と合併症

    岩崎 真樹, 高山 裕太郎, 横佐古 卓

    小児の脳神経   45 ( 3 )   233 - 233   2020.10

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  • てんかんの外科治療

    岩崎 真樹, 飯島 圭哉, 高山 裕太郎, 木村 唯子, 金子 裕, 住友 典子, 齋藤 貴志, 中川 栄二, 佐々木 征行

    脳と発達   52 ( Suppl. )   S74 - S74   2020.8

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  • Strategies of failed epilepsy surgery

    岩崎真樹, 飯島圭哉, 高山裕太郎, 木村唯子, 横佐古卓, 小杉健三, 金子裕

    日本てんかん外科学会プログラム・抄録集   44th   2020

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  • Genotype prediction with imaging features in low-grade epilepsy-associated neuroepithelial tumors

    飯島圭哉, 佐藤典子, 小杉健三, 横佐古卓, 高山裕太郎, 木村唯子, 金子裕, 岩崎真樹

    日本てんかん外科学会プログラム・抄録集   44th   2020

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  • Entropy analysis of scalp EEG is useful in predicting postoperative seizure outcomes of secondary surgery after corpus callosotomy

    小杉健三, 飯島圭哉, 横佐古卓, 高山裕太郎, 木村唯子, 金子裕, 岩崎真樹

    日本てんかん外科学会プログラム・抄録集   44th   2020

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  • Seizure and developmental outcome after epilepsy surgery in infancy

    岩崎真樹, 飯島圭哉, 高山裕太郎, 横佐古卓, 小杉健三, 木村唯子, 金子裕, 池谷直樹, 住友典子, 斎藤貴志, 中川栄二, 高橋章夫, 須貝研司, 大槻泰介

    日本てんかん外科学会プログラム・抄録集   44th   2020

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  • 精神科疾患に対するニューロモデュレーション トゥレット症候群に対する脳深部刺激療法における至適刺激部位

    木村 唯子, 飯島 圭哉, 高山 裕太郎, 村岡 範裕, 横佐古 卓, 金子 裕, 大森 まゆ, 岩崎 真樹

    日本定位・機能神経外科学会プログラム・抄録集   59回   84 - 84   2019.12

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  • 精神科疾患に対するニューロモデュレーション トゥレット症候群に対する脳深部刺激療法における至適刺激部位

    木村 唯子, 飯島 圭哉, 高山 裕太郎, 村岡 範裕, 横佐古 卓, 金子 裕, 大森 まゆ, 岩崎 真樹

    日本定位・機能神経外科学会プログラム・抄録集   59回   84 - 84   2019.12

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  • てんかんの認知機能の神経生理学的アプローチ てんかんの認知機能 外科治療がもたらす影響

    岩崎 真樹, 池谷 直樹, 飯島 圭哉, 高山 裕太郎, 村岡 範裕, 横佐古 卓, 木村 唯子, 金子 裕

    臨床神経生理学   47 ( 5 )   355 - 355   2019.10

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  • 心拍検出機能付き迷走神経刺激装置(AspireSR model106)の使用経験

    住友 典子, 岩崎 真樹, 横佐古 卓, 高山 裕太郎, 村岡 範裕, 飯島 圭哉, 木村 唯子, 金子 裕, 石山 昭彦, 齋藤 貴志, 中川 栄二, 佐々木 征行

    てんかん研究   37 ( 2 )   623 - 623   2019.9

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  • 外科的治療を行った脳腫瘍関連てんかん患者の脳波所見と発作転帰

    村岡 範裕, 飯島 圭哉, 高山 裕太郎, 横佐古 卓, 木村 唯子, 金子 裕, 岩崎 真樹

    てんかん研究   37 ( 2 )   561 - 561   2019.9

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  • 乳幼児てんかん外科の治療成績および合併症

    岩崎 真樹, 飯島 圭哉, 高山 裕太郎, 村岡 範裕, 横佐古 卓, 木村 唯子, 金子 裕, 住友 典子, 石山 昭彦, 齋藤 貴志, 中川 栄二, 佐々木 征行

    てんかん研究   37 ( 2 )   557 - 557   2019.9

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  • 側頭部てんかん性棘波と安静時脳機能結合の時間的・空間的な関連

    池谷 直樹, 岩崎 真樹, 高山 裕太郎, 山本 哲哉, 沼澤 秀美, 吉永 健二, 花川 隆

    てんかん研究   37 ( 2 )   652 - 652   2019.9

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  • 良性脳腫瘍によるてんかん患者のMEG所見

    金子 裕, 木村 唯子, 飯島 圭哉, 高山 裕太郎, 村岡 範裕, 横佐古 卓, 岩崎 真樹

    てんかん研究   37 ( 2 )   521 - 521   2019.9

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  • てんかんに対する定位的凝固治療

    岩崎 真樹, 高山 裕太郎, 飯島 圭哉, 木村 唯子, 村岡 範裕, 横佐古 卓, 金子 裕

    てんかん研究   37 ( 2 )   448 - 449   2019.9

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  • 心拍検出機能付き迷走神経刺激装置(AspireSR model106)の使用経験

    住友 典子, 岩崎 真樹, 横佐古 卓, 高山 裕太郎, 村岡 範裕, 飯島 圭哉, 木村 唯子, 金子 裕, 石山 昭彦, 齋藤 貴志, 中川 栄二, 佐々木 征行

    てんかん研究   37 ( 2 )   623 - 623   2019.9

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  • 乳幼児てんかん外科の治療成績および合併症

    岩崎 真樹, 飯島 圭哉, 高山 裕太郎, 村岡 範裕, 横佐古 卓, 木村 唯子, 金子 裕, 住友 典子, 石山 昭彦, 齋藤 貴志, 中川 栄二, 佐々木 征行

    てんかん研究   37 ( 2 )   557 - 557   2019.9

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  • 【てんかん外科と機能的脳神経外科】てんかん外科の課題とみらい

    岩崎 真樹, 飯島 圭哉, 高山 裕太郎, 木村 唯子, 金子 裕

    脳神経外科ジャーナル   28 ( 6 )   326 - 333   2019.6

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  • 発達障害とてんかん:各診療科の立場から てんかんの外科治療と認知発達機能への影響

    岩崎 真樹, 齋藤 貴志, 住友 典子, 飯島 圭哉, 高山 裕太郎, 村岡 範裕, 木村 唯子, 金子 裕, 中川 英二

    精神神経学雑誌   ( 2019特別号 )   S720 - S720   2019.6

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  • 内科的治療抵抗性の徐波睡眠期持続性棘徐波を示すてんかん性脳症に対する脳梁離断術の効果

    渡辺 詩絵奈, 竹下 絵里, 齋藤 貴志, 須貝 研司, 本橋 裕子, 石山 昭彦, 小牧 宏文, 中川 栄二, 佐々木 征行, 飯島 圭哉, 高山 裕太郎, 村岡 範裕, 木村 唯子, 岩崎 真樹

    脳と発達   51 ( Suppl. )   S375 - S375   2019.5

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  • 内科的治療抵抗性の徐波睡眠期持続性棘徐波を示すてんかん性脳症に対する脳梁離断術の効果

    渡辺 詩絵奈, 竹下 絵里, 齋藤 貴志, 須貝 研司, 本橋 裕子, 石山 昭彦, 小牧 宏文, 中川 栄二, 佐々木 征行, 飯島 圭哉, 高山 裕太郎, 村岡 範裕, 木村 唯子, 岩崎 真樹

    脳と発達   51 ( Suppl. )   S375 - S375   2019.5

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  • 脳神経外科コントロバーシー2019 てんかん外科における頭蓋内脳波の適応

    岩崎 真樹, 高山 裕太郎, 飯島 圭哉, 木村 唯子, 村岡 範裕, 金子 裕

    Neurological Surgery   47 ( 1 )   5 - 14   2019.1

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  • 徐波睡眠時持続性棘徐波を示すてんかん性脳症に脳梁離断術を行った3例

    村岡範裕, 木村唯子, 飯島圭哉, 高山裕太郎, 金子裕, 石山昭彦, 齋藤貴志, 中川栄二, 岩崎真樹

    日本てんかん外科学会プログラム・抄録集   42nd   2019

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  • 過運動発作を呈した前頭葉てんかんに対する外科治療

    大沢 伸一郎, 岩崎 真樹, 高山 裕太郎, 神 一敬, 中里 信和, 冨永 悌二

    脳神経外科ジャーナル   27 ( 10 )   764 - 772   2018.10

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  • 限局性皮質異形成の手術計画におけるブドウ糖代謝低下領域の意義

    飯島 圭哉, 高山 裕太郎, 村岡 範裕, 木村 唯子, 金子 裕, 森本 笑子, 佐藤 典子, 齊藤 祐子, 池谷 直樹, 岩崎 真樹

    てんかん研究   36 ( 2 )   433 - 433   2018.9

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  • 硬膜下電極だけでは不十分である

    金子 裕, 池谷 直樹, 飯島 圭哉, 木村 唯子, 村岡 範裕, 高山 裕太郎, 岩崎 真樹

    てんかん研究   36 ( 2 )   421 - 421   2018.9

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  • 大学病院てんかん科における医学科学生実習カリキュラム

    柿坂 庸介, 神 一敬, 藤川 真由, 北澤 悠, 上利 大, 高山 裕太郎, 小川 舞美, 中里 信和

    てんかん研究   36 ( 2 )   456 - 456   2018.9

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  • 発作間欠時てんかん棘波が内側側頭葉てんかんの安静時脳機能結合に与える影響

    池谷 直樹, 岩崎 真樹, 高山 裕太郎, 沼澤 秀美, 吉永 健二, 花川 隆

    てんかん研究   36 ( 2 )   516 - 516   2018.9

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  • シリーズ開始時スパズムの頭蓋内脳波解析による切除術の適応

    住友 典子, 池谷 直樹, 高山 裕太郎, 村岡 範裕, 飯島 圭哉, 木村 唯子, 金子 裕, 中川 栄二, 須貝 研司, 佐々木 征行, 岩崎 真樹

    てんかん研究   36 ( 2 )   511 - 511   2018.9

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  • 大学病院てんかん科における医学科学生実習カリキュラム

    柿坂 庸介, 神 一敬, 藤川 真由, 北澤 悠, 上利 大, 高山 裕太郎, 小川 舞美, 中里 信和

    てんかん研究   36 ( 2 )   456 - 456   2018.9

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  • 脳磁図の再評価とさらなる発展を目指して 電流双極子によるてんかん波形の解釈 てんかん診療における脳磁図の役割と電流双極子モデルの意味

    柿坂 庸介, 神 一敬, 北澤 悠, 上利 大, 高山 裕太郎, 大沢 伸一郎, 菅野 彰剛, 中里 信和

    日本生体磁気学会誌   31 ( 1 )   42 - 43   2018.6

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  • 脳磁図の再評価とさらなる発展を目指して 電流双極子によるてんかん波形の解釈 てんかん診療における脳磁図の役割と電流双極子モデルの意味

    柿坂 庸介, 神 一敬, 北澤 悠, 上利 大, 高山 裕太郎, 大沢 伸一郎, 菅野 彰剛, 中里 信和

    日本生体磁気学会誌   31 ( 1 )   42 - 43   2018.6

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  • 良性成人型家族性ミオクローヌてんかんの患者で発作間欠時に認めたPhantom spike and waveと振戦様ミオクローヌスとの関連について

    上利 太, 柿坂 庸介, 神 一敬, 高山 裕太郎, 北澤 悠, 藤川 真由, 菅野 彰剛, 中里 信和

    てんかん研究   35 ( 3 )   742 - 742   2018.1

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  • 松果体部胚細胞腫瘍に対する集学的治療後に発症したてんかん患者の臨床的特徴

    高山裕太郎, 柿坂庸介, 大沢伸一郎, 神一敬, 菅野彰剛, 菅野彰剛, 岩崎真樹, 北澤悠, 上利大, 冨永悌二, 中里信和, 中里信和

    日本てんかん外科学会プログラム・抄録集   41st   2018

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  • 主成分分析により発作症状に合致した伝播現象を説明できた難治てんかん2例

    菅野 彰剛, 石田 誠, 神 一敬, 柿坂 庸介, 北澤 悠, 高山 裕太郎, 上利 大, 中里 信和

    臨床神経生理学   45 ( 5 )   409 - 409   2017.10

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  • 強直間代発作に伴い肩関節脱臼を呈したてんかん患者3例

    上利 大, 神 一敬, 加藤 量広, 高山 裕太郎, 北澤 悠, 藤川 真由, 柿坂 庸介, 菅野 彰剛, 中里 信和

    てんかん研究   35 ( 2 )   644 - 644   2017.9

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  • 動眼神経単独麻痺を呈した下垂体卒中の77歳男性例 Reviewed

    鈴木 聡, 小泉 寛之, 石戸 淳一, 桃尾 隆之, 岩田 盾也, 高山 裕太郎, 小島 昭雄, 田中 章景

    臨床神経学   57 ( 6 )   333 - 333   2017.6

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  • Comparison of MEG findings between patients with dysembryoplastic neuroepithelial tumor and ganglioglioma

    TAKAYAMA Yutaro, JIN Kazutaka, KAKISAKA Yosuke, KITAZAWA Yu, AGARI Dai, KANNO Akitake, KANNO Akitake, ISHIDA Makoto, NAKASATO Nobukazu, NAKASATO Nobukazu

    日本生体磁気学会誌   30 ( 1 )   2017

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  • 小児ランゲルハンス細胞組織球症の臨床的検討

    伊藤 進, 高山 裕太郎, 高寺 睦見

    小児の脳神経   38 ( 1 )   121 - 121   2013.4

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  • Normal volume hydrocephalus 脳室拡大が非常に僅かなシャント不全

    伊藤 進, 高山 裕太郎, 高寺 睦見

    小児の脳神経   38 ( 1 )   82 - 82   2013.4

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  • 脳卒中を発症した妊婦の転院受け入れの問題点

    間中 浩, 篠原 禎雄, 高山 裕太郎, 川崎 隆, 坂田 勝巳, 濱田 幸一, 森村 尚登, 今井 雄一, 片山 春奈, 奥田 美加

    日本脳神経外科救急学会プログラム・抄録集   18回   108 - 108   2013.2

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  • 脳梗塞急性期にたこつぼ型心筋症を合併した66歳男性例

    高山 裕太郎, 上中 健, 北村 美月, 中山 貴博, 今福 一郎

    臨床神経学   51 ( 5 )   379 - 379   2011.5

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Awards

  • 2026 Japanese Congress of Neurological Surgeons (JCNS) Young Investigator Research Grant

    2025.12   The Japanese Congress of Neurological Surgerons  

    Yutaro Takayama

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  • Yokohama City University President’s Discretionary Academic Research Promotion Program: “International Joint Research Project.”

    2025.7   Yokohama City University  

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  • AES Young Investigator Award 2023

    2023.12   American Epilepsy Society  

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  • JERF2013

    2023.3   The Japan Epilepsy Research Foundation  

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  • Wakaba Research Grant

    2022.8   Yokohama Foundation for Comprehensive Medical Promotion  

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  • research grant

    2022.8   Yokohama Academic Foundation  

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  • Best Presentation Award

    2021.12   The 51th Annual Meeting of the Japanese Society of Clinical Neurophysiology (JSCN)   SEEG and Stereotactic RadioFrequency-ThermoCoagulation for Operuculoinsular Epilepsy

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  • The Poster Award

    2021.10   The Japan Epilepsy Society  

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  • Best research award 2021

    2021.9   Japanese Society for Medical and Biological Engineering  

    Yuki Takayanagi, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Yumie Ono

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  • 調査研究助成

    2021.7   公益財団法人 神経研究所  

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  • Best Presentation Award (Clinical Section), Hospital Research Meeting

    2021.3   National Center of Neurology and Psychiatry, National Center Hospital  

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  • JES Sponsored Award 2020

    2020.4   The Japan Epilepsy Society  

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  • 一般研究助成

    2020.2   公益財団法人 日本脳神経財団  

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Research Projects

  • Investigation of Resting-State Thalamocortical Networks Underlying Consciousness Control

    2026.4 - 2027.3

    2026 Young Investigator Research Grant (Second Call), Japanese Congress of Neurological Surgeons 

    Yutaro Takayama, George M Ibrahim, Kazumasa Uehara

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    Authorship：Principal investigator 

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  • Elucidating Resting-State Thalamo-Cortical Networks as Mechanisms of Consciousness Control

    2025.7 - 2026.6

    Yokohama City University  University President’s Discretionary Program for Academic Research Promotion: International Collaborative Research Project 

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    Authorship：Principal investigator 

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  • Quantifying Early Epilepsy Networks Using Nonlinear Dynamics International coauthorship

    Grant number：2023H2002  2024.4 - 2025.3

    Nakatani Foundation for advancement of Measuring Technologies in Biomedical Engineering  FY2023 Technical Exchange Support 

    Yutaro Takayama

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\6285000 （ Direct Cost: \6285000 ）

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  • Quantifying Early Epilepsy Networks Using Dynamic Network Analysis

    2024.4 - 2025.3

    Yokohama City University School of Medicine Alumni Association Gushin-kai  Gushin-kai Fellowship 

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    Grant type：Competitive

    Grant amount：\500000 （ Direct Cost: \500000 ）

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  • 非線形ダイナミクスを用いたてんかん発作早期ネットワークの定量化

    Grant number：23KK0294  2024.3 - 2026.3

    日本学術振興会  科学研究費助成事業  国際共同研究加速基金(国際共同研究強化)

    高山 裕太郎

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    Authorship：Principal investigator 

    Grant amount：\14820000 （ Direct Cost: \11400000 、 Indirect Cost：\3420000 ）

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  • Visualization of Early Seizure Propagation Dynamics Focusing on Flexibility in Epilepsy Networks

    Grant number：23K15651  2023.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • title

    2022.4 - 2023.3

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\500000 （ Direct Cost: \500000 ）

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  • 非線形ダイナミクス解析を用いたヒトてんかんネットワークの時系列変容の解明〜定位的頭蓋内脳波 記録を用いた検討〜

    2022.4 - 2023.3

    一般財団法人 横浜総合医学振興財団 わかば研究助成 

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\500000 （ Direct Cost: \500000 ）

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  • てんかんの外科治療予後を向上させる頭蓋内脳波解析アルゴリズムの開発

    2020.4 - 2021.3

    公益財団法人 神経研究所 調査研究助成 

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  • 深部電極と深部電極を併用した効果的な頭蓋内電極留置方法の探索 と頭蓋内脳波判読における標準化の検討

    2019.4 - 2020.3

    国立研究開発法人国立精神・神経医療研究センター 若手臨床研究グループ活動奨励研究費 

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    Authorship：Principal investigator 

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  • Identification of cortical areas associated with temporal patterns of muscle synergy using intracranial EEG

    2019.4

    Japan Brain Foundation  Neurophysiology

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Other

  • 日本てんかん学会指導医

    2025.10

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  • 日本臨床神経生理学会専門医（脳波分野）

    2022.9

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  • Board Certification of Japanese Society of Pediatric Neurosurgery

    2022.5

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  • 日本てんかん学会専門医

    2021.8

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  • 日本定位・機能神経外科学会 機能的定位脳手術技術認定医

    2021.1

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  • 日本脳神経外科学会専門医

    2016.8

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Social Activities

  • Yokohama City University Neuroscience Conference

    Role(s)： Lecturer

    Department of Physiology, Yokohama City University  2023.12

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    Type：Seminar, workshop

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  • Epilepsy and Corona: Focusing on the Sequelae

    Role(s)： Contribution

    The Epilepsy Association of Japan, Tokyo Branch  Tomoshibi  2023.5

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    Type：Promotional material

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  • Music and Brain Science

    Role(s)： Lecturer

    Ferris University, Department of Music and Arts  2022.9 - 2024.3

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    Type：Visiting lecture

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  • 第22回 藤田医科大学脳神経外科勉強会 講師

    Role(s)： Lecturer

    藤田医科大学 ばんたね病院 

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    Type：Seminar, workshop

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  • Asian Congress of Neurological Surgeons Webinar: Radiofrequency-thermocoagulation for pediatric insulo-opercular epilepsy Asian Congress of Neurological Surgeons Jun. 2024, Webiner（Invited）

    Role(s)： Lecturer

    Asian Congress of Neurological Surgeons 

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    Type：Lecture

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Media Coverage

  • Yokohama City University, Stereotactic Intracranial Electrode Implantation/Intracranial EEG (SEEG) Newspaper, magazine

    https://www.nikkei.com/article/DGXZRSP639697_X00C22A9000000/  2022.9

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  • Stereotactic Intracranial Electrode Placement/Intracranial Electroencephalogram (SEEG), a world first with Cirq robotic arm Newspaper, magazine

    https://www.okinawatimes.co.jp/articles/-/1020255  2022.9

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  • New Hope for Treatment of Refractory Epilepsy Internet

    https://medical.jiji.com/news/52955  2022.6

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  • Yokohama City University and National Center of Neurology and Psychiatry propose radiofrequency thermocoagulation (RFTC) for epilepsy and report treatment experience. Newspaper, magazine

    https://www.nikkei.com/article/DGXZRSP634849_R20C22A6000000/  2022.6

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  • Expectations for a New Epilepsy Surgical Treatment that Does Not Require Resection of the Brain - Radiofrequency Focused Thermal Coagulation of Epilepsy Newspaper, magazine

    https://mainichi.jp/articles/20220621/pls/00m/020/260000c  2022.6

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