Researcher Profile - Mamoru Uchiyama

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写真a

Mamoru Uchiyama

Organization

Yokohama City University Hospital Gastrointestinal Surgery Assistant Professor

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Research Areas

Life Science / Digestive surgery

Papers

C-reactive protein-to-albumin ratio as a risk factor for anastomotic leakage after anterior resection for rectal cancer with intraoperative use of indocyanine green fluorescence imaging. International journal

Tatsunosuke Harada, Masakatsu Numata, Shota Izukawa, Yosuke Atsumi, Keisuke Kazama, Sho Sawazaki, Teni Godai, Hiroyuki Mushiake, Nobuhiro Sugano, Mamoru Uchiyama, Akio Higuchi, Hiroshi Tamagawa, Yusuke Suwa, Jun Watanabe, Tsutomu Sato, Chikara Kunisaki, Aya Saito

Surgical endoscopy 38 ( 8 ) 4236 - 4244 2024.8

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INTRODUCTION: Indocyanine green fluorescence imaging (ICG-FI) reduces anastomotic leakage (AL) in rectal cancer surgery. However, no studies investigating risk factors for anastomotic leakage specific to the group using ICG-FI have ever previously been conducted. The purpose of this retrospective multicenter study was to ascertain the risk factors for AL in the group using ICG-FI. METHODS: A total of 638 patients who underwent laparoscopic or robotic anterior resection for rectal cancer between April 2018 and March 2023 were included in this study. Patients were divided into two groups: the ICG-FI group (n = 269) and the non-ICG-FI group (n = 369) for comparative analysis. The effects of clinicopathological and treatment-related factors on AL in the ICG-FI group were evaluated using both univariate and multivariate analyses. RESULTS: The incidence of AL in the ICG-FI group was 4.8%. Although there was no significant difference in the incidence of AL between the two groups, it was observed to be lower in the ICG-FI group. A multivariate analysis revealed a preoperative C-reactive protein-to-albumin ratio (CAR) ≥ 0.049 (odds ratio, 3.73; 95% confidence interval, 1.01-13.70; p = 0.048) as an independent risk factor for AL in the ICG-FI group. CONCLUSIONS: In this study, CAR was the only identified risk factor for AL in the ICG-FI group. It was suggested that CAR could be a criterion for early surgical intervention, prior to the escalation of risks, or for considering interventions such as diverting stoma creation.

DOI： 10.1007/s00464-024-10940-6

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Correction: C-reactive protein-to-albumin ratio as a risk factor for anastomotic leakage after anterior resection for rectal cancer with intraoperative use of indocyanine green fluorescence imaging. International journal

Tatsunosuke Harada, Masakatsu Numata, Shota Izukawa, Yosuke Atsumi, Keisuke Kazama, Sho Sawazaki, Teni Godai, Hiroyuki Mushiake, Nobuhiro Sugano, Mamoru Uchiyama, Akio Higuchi, Hiroshi Tamagawa, Yusuke Suwa, Jun Watanabe, Tsutomu Sato, Chikara Kunisaki, Aya Saito

Surgical endoscopy 38 ( 8 ) 4763 - 4763 2024.8

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DOI： 10.1007/s00464-024-11004-5

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Temporal dynamics of RAS mutations in circulating tumor DNA in metastatic colorectal cancer: clinical significance of mutation loss during treatment. International journal

Kenta Iguchi, Manabu Shiozawa, Mamoru Uchiyama, Masahiro Asari, Koji Numata, Yasushi Rino, Aya Saito

Journal of cancer research and clinical oncology 150 ( 5 ) 281 - 281 2024.5

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PURPOSE: In metastatic colorectal cancer (mCRC), RAS mutation loss may occur during the standard-of-care regimen. In this study, we aimed to investigate the temporal dynamics of the RAS gene and its clinical significance. METHODS: This was a retrospective, single-center study that included 82 patients with tissue RAS-mutant (RAS-MT) mCRC who underwent circulating tumor DNA (ctDNA) RAS monitoring between January, 2013-April, 2023. Patients were analyzed for the rate of change over time to acquired RAS mutation loss (aRAS-ML) and clinicopathological factors. The prognostic relevance of mutation loss was assessed. RESULTS: aRAS-ML was detected in 33 (40.2%) patients, 32 of whom had a mutation loss in the first ctDNA RAS assay. Patients with a RAS mutation detected in the first assay had a median time of 8 months until the second ctDNA RAS assay, with 4.5% cases newly converted to aRAS-ML; no new conversions were detected at the third assay. The aRAS-ML group exhibited more single-organ metastases in the target organ during ctDNA measurement (aRAS-ML: 84.8% vs. RAS-MT: 59.2%, p = 0.02). Of the 33 patients with aRAS-ML, seven (21.2%) received anti-epidermal growth factor receptor (EGFR) therapy, with a median progression-free survival of 8 months. Multivariate analysis revealed that persistent ctDNA RAS mutation was an independent prognostic factor for overall survival (hazard ratio: 2.7, 95% confidence interval: 1.1-6.3, p = 0.02). CONCLUSION: The rate of ctDNA mutation loss in patients with RAS-MT mCRC decreases over time. Therefore, using a ctDNA RAS assay early in treatment will assist in challenging the use of EGFR regimens.

DOI： 10.1007/s00432-024-05805-3

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[A Case of Distal Gastrectomy and Left Segmentectomy for Hepatic Invasion of Gastric Cancer].

Yuta Nakayama, Kazuki Koyama, Koichiro Shimizu, Rei Kanemoto, Nozomi Urata, Keisuke Komori, Mamoru Uchiyama, Yoshihiro Suzuki, Yasushi Rino, Aya Saito

Gan to kagaku ryoho. Cancer & chemotherapy 51 ( 4 ) 457 - 459 2024.4

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A 66-year-old male came to our hospital because of occult blood in stool and anemia. The patient was diagnosed as unresectable advanced gastric cancer,( ML/Less, type 2, tub2, cT4b[liver], cN+, cM0, cStage Ⅳ, HER2 negative). He was given oxaliplatin plus S-1 therapy. In the 3rd course of chemotherapy, he had severe anemia, and active bleeding from the tumor. To control the bleeding he underwent distal gastrectomy, lateral segmentectomy of the liver, and S4 partial hepatectomy. The patient underwent adjuvant chemotherapy with docetaxel plus S-1. Three months after surgery, lymph nodes recurrence was observed. He underwent second-line therapy with paclitaxel and ramucirumab. Seven months after surgery, lymph nodes recurrence was increased. He was switched to third-line therapy with nivolumab. He is currently arrive 12 months after surgery.

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[A Case of Colon Metastasis after Surgery for Left Renal Pelvis Cancer].

Keisuke Komori, Kazuki Koyama, Koichiro Shimizu, Rei Kanemoto, Yuta Nakayama, Nozomi Urata, Mamoru Uchiyama, Yoshihiro Suzuki, Yasushi Rino, Aya Saito

Gan to kagaku ryoho. Cancer & chemotherapy 51 ( 3 ) 340 - 342 2024.3

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The patient was a 73-year-old man. He was diagnosed with left renal pelvic carcinoma(papillary urothelial carcinoma, pT3aN0M0, Stage Ⅱ)at the age of 69. Left nephroureterectomy and partial cystectomy were performed at our hospital. At the age of 71, he was diagnosed with a recurrent bladder tumor and underwent radical cystectomy and ureteroenterostomy at a different hospital. At the age of 73, he visited our hospital with abdominal pain. Computed tomography(CT)revealed wall thickening of the descending colon and dilation of the oral tract. Emergency colonoscopy was performed. He was diagnosed with intestinal obstruction due to descending colon cancer. Colonoscopy revealed a circumferential type 2 lesion in the descending colon that was completely stenosed. Colonic stent placement was performed. A tumor biopsy confirmed the diagnosis of micropapillary adenocarcinoma. The preoperative diagnosis was descending colon cancer cT4aN2aM0, cStage Ⅲc. One month after stent placement, an open segmental resection of the descending colon with D2 dissection was performed. Immunostaining of the specimen showed CK7(+)and CK20(-), and the postoperative diagnosis was a recurrence of left renal pelvic carcinoma in the descending colon. We report a rare case of renal pelvic carcinoma that recurred in the descending colon 4 years after initial surgery.

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Clinical significance of the post/preoperative anti-p53 antibody ratio in predicting the prognosis of patients with colorectal cancer after curative surgery and its usefulness in combination with carcinoembryonic antigen. International journal

Koji Numata, Manabu Shiozawa, Yukari Ono, Kenta Iguchi, Mamoru Uchiyama, Masahiro Asari, Yasushi Rino, Aya Saito

Oncology 2024.2

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[Introduction] Anti-p53 antibody (p53Ab) is useful for monitoring colorectal cancer (CRC) recurrence. We retrospectively analyzed the clinical impact of p53Ab ratio (p53R) before and after surgery to predict recurrence in patients with CRC. [Methods] In total, 1,223 patients with stage I-III CRC who underwent curative surgery between January 2005 and December 2019 were enrolled in this retrospective study. In patients with elevated p53Ab levels, p53R was calculated by measuring p53Ab levels within one month preoperatively and three months postoperatively. The optimal p53R level was determined, and its relationship with clinicopathological factors and prognosis was examined. We also evaluated the efficacy of the combination of p53R and preoperative carcinoembryonic antigen (CEA) values. [Results] Overall, 341 patients (27.9%) showed elevated p53Ab levels. Preoperative p53Ab levels were significantly associated with tumor location, lymphatic invasion, and venous invasion. The p53R level was significantly higher in patients with recurrent disease. Patients with high p53R levels had significantly shorter relapse-free survival (RFS) than those with low p53R levels (p < 0.001). When p53R was combined with preoperative CEA values, specificity improved to 0.97, with an accuracy of 0.88. [Conclusion] In patients with CRC and elevated preoperative p53Ab levels, p53R expression may be prognostically useful after radical resection. Furthermore, the combination of p53R and preoperative CEA levels may be useful for postoperative follow-ups.

DOI： 10.1159/000537963

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[A Case of Meningeal Carcinomatosis following Esophagogastric Junction Cancer Surgery].

Tomohiro Arai, Keisuke Komori, Nozomi Urata, Mamoru Uchiyama, Yoshihiro Suzuki, Yasushi Rino, Aya Saito

Gan to kagaku ryoho. Cancer & chemotherapy 51 ( 1 ) 78 - 80 2024.1

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In a 79-year-old man, upper gastrointestinal endoscopy and CT revealed an entire circumferential type 3 tumor with stenosis from the lower thoracic esophagus to the abdominal esophagus. He was diagnosed with esophageal adenocarcinoma and underwent middle and lower esophageal resection and 2 regional lymph node dissections. The postoperative pathological diagnosis was poorly differentiated adenocarcinoma, pT3N0M0, pStage ⅡA esophagogastric junction cancer(Siewert type Ⅱ). The patient was followed-up without postoperative adjuvant chemotherapy, following the Japanese Gastric Cancer Treatment Guidelines 2021(6th edition). Six months postoperatively, contrast-enhanced CT revealed multiple lymph node, small intestinal mesenteric, and left adrenal metastases, and SOX therapy was initiated. After 4 courses of SOX therapy, the patient was brought to the emergency room and admitted with anorexia and weakness, and consciousness disorder was observed on the next day. Contrast-enhanced MRI of the head was indicative of meningeal carcinomatosis, and cytological examination of the spinal fluid revealed adenocarcinoma, which was diagnosed as meningeal carcinomatosis from esophagogastric junction carcinoma. Subsequently, his consciousness disorder worsened, and he died on the 9th day of hospitalization. We report a rare case of meningeal carcinomatosis following esophagogastric junction cancer.

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Short- and long-term outcomes of transanal decompression tube and self-expandable metallic stent for obstructive colorectal cancer based on a multicenter database (KYCC2110). International journal

Koji Numata, Masakatsu Numata, Junya Shirai, Sho Sawazaki, Hironao Okamoto, Teni Godai, Yusuke Katayama, Yosuke Atsumi, Keisuke Kazama, Mamoru Uchiyama, Takashi Kohmura, Hiroyuki Mushiake, Nobuhiro Sugano, Akio Higuchi, Aya Kato, Kenta Iguchi, Yasushi Rino, Manabu Shiozawa

Journal of surgical oncology 128 ( 8 ) 1372 - 1379 2023.12

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AIM: There are well-known methods for decompressing the colorectal tract before surgery, including transanal decompression tubes (TDT) and self-expanding metallic stents (SEMS). This study aimed to compare the short and long-term results in patients with malignant large bowel obstruction in whom TDT or SEMS were placed before surgery. METHODS: This retrospective observational study enrolled 225 patients with malignant large bowel obstruction in whom TDT or SEMS were placed preoperatively and underwent R0 resection between 2008 and 2020. One-to-two propensity score matching was performed according to patient characteristics. Short- and long-term outcomes were compared. The primary endpoint was relapse-free survival (RFS). The secondary endpoints were the overall survival (OS) and postoperative complication rate. RESULTS: Fifty-seven patients in the TDT group and 114 in the SEMS group were matched. The 3-year RFS rates were 66.7% in the TDT group and 69.9% in the SEMS group (p = 0.54), and the 3-year OS rates were 90.5% in the TDT group and 87.1% in the SEMS group (p = 0.52). No significant differences in the long-term results were observed between the two groups. Regarding short-term results, the SEMS group had significantly fewer stoma construction (p = 0.007) and shorter postoperative hospitalization (p < 0.001). The incidence of postoperative complications (grade ≥ 2) was significantly lower in the SEMS group (p = 0.04). CONCLUSION: No significant differences in the long-term results were observed between the TDT and SEMS group. The SEMS showed significant usefulness in terms of improving short-term outcomes.

DOI： 10.1002/jso.27454

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Comparison of safety and efficacy of fluorouracil + oxaliplatin + irinotecan (FOLFOXIRI) and modified FOLFOXIRI with bevacizumab for metastatic colorectal cancer: data from clinical practice. International journal

Keisuke Kazama, Manabu Shiozawa, Masakatsu Numata, Nobuhiro Sugano, Sumito Sato, Mamoru Uchiyama, Maho Sato, Toru Aoyama, Hiroshi Tamagawa, Takashi Oshima, Norio Yukawa, Yasushi Rino

International journal of colorectal disease 37 ( 2 ) 337 - 348 2022.2

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PURPOSE: The efficacy of fluorouracil + oxaliplatin + irinotecan with bevacizumab (FOLFOXIRI + BV) has been verified for metastatic colorectal cancer (mCRC). In clinical practice, the original (O-FOLFOXIRI + BV) and modified dose settings (M-FOLFOXIRI + BV) are adopted for Asian patients. We aimed to compare the real-world efficacy and safety of these two regimens. METHODS: This retrospective cohort study reviewed clinical data of all consecutive mCRC patients treated with FOLFOXIRI + BV at a cancer centre in Japan. One hundred patients were divided into two groups: one that received O-FOLFOXIRI + BV (group O, n = 30) and another that received M-FOLFOXIRI + BV (group M, n = 70). Progression-free survival (PFS) was set as the primary endpoint, with overall survival (OS), overall response rate (ORR), and safety as secondary endpoints. RESULTS: PFS was superior in group M (median PFS; 8.7 vs. 11.5 months, P = 0.098). The use of O-FOLFOXIRI + BV emerged as an independent risk factor of poor PFS (hazard ratio = 2.155, P = 0.012). Both ORR (43.3 vs. 65.7%, P = 0.047) and OS (median OS; 17.9 vs. 27.0 months, P = 0.127) were more favourable in group M. Grade ≥ 3 adverse events were more frequently observed in group O (90 vs. 74.3%, P = 0.108), whereas dose intensity was higher in group M because a shorter duration was required for cytotoxic drug administration (2.9 vs. 2.6 weeks/course, P = 0.051) in the induction term. CONCLUSION: We found that M-FOLFOXIRI + BV had more favourable efficacy and safety than O-FOLFOXIRI + BV, which may be a better fit for Asian patients and can be potentially used as an alternative for upfront chemotherapy for mCRC.

DOI： 10.1007/s00384-021-04064-9

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Prospective analysis of tumor spread to the small bowel mesentery in cases of right-sided colon cancer. International journal

Sumito Sato, Manabu Shiozawa, Nobuhiro Sugano, Akio Higuchi, Keisuke Kazama, Aya Kato, Mamoru Uchiyama, Hironao Okamoto, Takashi Kohmura, Takashi Oshima, Yasushi Rino, Munetaka Masuda

Langenbeck's archives of surgery 405 ( 8 ) 1139 - 1145 2020.12

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PURPOSE: Guidelines advocate minimal ileal resection when right hemicolectomy is performed for right-sided colon cancer. The practice, thought to prevent malabsorption syndrome, does not appear to foster local recurrence. Little evidence based on rigorous study exists, however. To understand the pattern of lymphatic spread of right-sided colon cancer toward the small bowel and thus determine the appropriate margin size, we prospectively investigated anatomical distribution of lymph nodes (LNs) in the small bowel mesentery and of metastasis to these nodes in patients with right-sided colon cancer treated by such surgery. METHODS: In each case, the mesenteric specimen, which had been dissected along the ileocolic vessels and included intermediate LNs, was divided into 2 areas: that 0-3 cm from the vessel pedicle (area 1) and that 3-5 cm from the pedicle (area 2). The peri-intestinal mesentery was cut into 9 segments. RESULTS: Ninety-one patients were included in the study. Overall, 3366 LNs were dissected. Four hundred fifty-three of these LNs were located in area 1 (90 cases), and 15 (3.3%) were metastatic. Only 63 LNs were located in area 2 (34 cases; average of 0.69 per patient); none was metastatic. Overall, 269 LNs were found in the small bowel mesentery (in 56 of the 91 patients). Only 4 were positive (3 cases), and all were within 5 cm of the ileocecal valve. CONCLUSION: Our data indicate that a surgical margin 3 cm from the ileocecal pedicle and a short (5 cm) ileal margin are oncologically reasonable for effective right hemicolectomy.

DOI： 10.1007/s00423-020-02016-5

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高齢者大腸癌手術におけるD3リンパ節郭清の意義 Reviewed

淺利昌大, 青山徹, 公盛啓介, 内山護, 前澤幸男, 澤崎翔, 沼田正勝, 玉川洋, 佐藤勉, 大佛智彦, 谷和行, 湯川寛夫, 利野靖, 益田宗孝

癌と化学療法 47 ( 2 ) 259 - 261 2020.2

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[The Efficacy of D3 Lymph Node Dissection in Elderly Patients with Colorectal Cancer].

Masahiro Asari, Toru Aoyama, Keisuke Koumori, Mamoru Uchiyama, Yukio Maezawa, Sho Sawazaki, Masakatsu Numata, Hiroshi Tamagawa, Tsutomu Sato, Tomohiko Osaragi, Kazuyuki Tani, Norio Yukawa, Yasushi Rino, Munetaka Masuda

Gan to kagaku ryoho. Cancer & chemotherapy 47 ( 2 ) 259 - 261 2020.2

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The effectiveness of lymph node dissection tends to be reduced clinically in elderly patients with colorectal cancer because of physical limitations, such as comorbidities and organ dysfunction. We investigated the influence of the level of lymph node dissection on the prognosis of elderly patients with colorectal cancer. A total of 137 patients with pT2 or more-advanced tumors or lymph node metastasis were retrospectively studied. The 5-year overall survival(OS)andrelapse free survival(RFS) rates were 74.1% and 63.9%, respectively. Lymph node dissection was an independent prognostic factor in the examination of prognostic factors of OS. In the propensity-matchedcohort, the 5-year OS rates were 87.2% and5 8.2%(p=0.02), and the 5-year RFS rates were 77.8% and4 6.4%(p=0.03)in the D3 andred ucedgroups, respectively. The D3 group hada significantly better prognosis than the reduced group. D3 lymph node dissection might contribute to the improvement of prognosis in elderly people with colorectal cancer.

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Triplet regimenの臨床的位置づけと副作用のマネージメント実臨床におけるFOLFOXIRI+Bevacizumabの治療成績と、今後の課題 Reviewed

風間慶祐, 塩澤学, 内山護, 加藤綾, 佐藤純人, 菅野信洋, 沼田正勝, 青山徹, 玉川洋, 湯川寛夫, 大島貴, 利野靖, 益田宗孝

日本大腸肛門病学会雑誌 72 ( 9 ) A75 - A75 2019.9

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腹腔鏡手術後の5mmポート孔に生じたヘルニア嵌頓の1例

内山護, 佐藤純人, 塩澤学, 菅野伸洋, 加藤綾, 利野靖, 益田宗孝

横浜医学 70 ( 2 ) 123 - 127 2019.5

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2019&ichushi_jid=J01499&link_issn=&doc_id=20190913400006&doc_link_id=https%3A%2F%2Fycu.repo.nii.ac.jp%2Frecords%2F1844&url=https%3A%2F%2Fycu.repo.nii.ac.jp%2Frecords%2F1844&type=%E6%A8%AA%E6%B5%9C%E5%B8%82%E7%AB%8B%E5%A4%A7%E5%AD%A6%EF%BC%9A%E6%A8%AA%E6%B5%9C%E5%B8%82%E7%AB%8B%E5%A4%A7%E5%AD%A6%E5%AD%A6%E8%A1%93%E6%A9%9F%E9%96%A2%E3%83%AA%E3%83%9D%E3%82%B8%E3%83%88%E3%83%AA&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80205_3.gif
Correlation between endoscopic features of the anastomosis after low anterior resection and postsurgical anorectal function. International journal

Sumito Sato, Manabu Shiozawa, Mamoru Uchiyama, Nobuhiro Sugano, Yasushi Rino, Munetaka Masuda

Journal of gastrointestinal oncology 10 ( 2 ) 188 - 193 2019.4

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BACKGROUND: With low anterior resection (LAR) for rectal cancer, the oncologic outcomes are recently good. A diverting ileostomy is often created to protect the newly constructed anastomosis; seldom is a permanent stoma needed. Predicting postoperative anorectal function remains difficult, however. We speculated that the endoscopic appearance of the anastomosis before ileostomy closure is predictive of the post-operative anorectal function and tested our hypothesis retrospectively. METHODS: Included in the study were 80 patients who, between September 2014 and August 2017, underwent LAR at Kanagawa Cancer Center. A diverting stoma had been created during the primary surgery, and ileostomy closure was performed about 6 months later. The anastomosis was examined endoscopically just before ileostomy closure, and the features were scored by two well-trained endoscopists. Daily defecation frequency and incontinence (Kirwan Score) were assessed after closure through physician-patient interview, and correlation between endoscopic feature scores and these measures of anorectal function was tested. RESULTS: Documented endoscopic features included erythema in 79% of patients, erosion (45%), ulceration (5%), granulomatous change (41.3%), granular protrusions (17.5%); hemorrhagic (20.0%) or white-coated (30.0%) mucosa. Anastomosis stricture <9 mm was 17.5%. Median daily defecation frequency after ileostomy closure was 4 (range, 0-20). Moderate positive correlation was found between endoscopic scores and postoperative anorectal function (r=0.60, P<0.001). CONCLUSIONS: In recording and analyzing endoscopic features of the anastomosis before ileostomy closure in a large number of patients treated by LAR, we found that the features might indeed be clinically useful in predicting post-LAR anorectal function.

DOI： 10.21037/jgo.2018.11.09

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[A Case of Solitary Adrenal Metastasis from Rectal Cancer Treated by Adrenalectomy after Preoperative Chemotherapy].

Kazuhito Tsuchida, Hayato Watanabe, Yohei Kameda, Mamoru Uchiyama, Masahiro Asari, Hitoshi Matsuura, Kazuki Yamanaka, Tomohiko Osaragi, Kazuyuki Tani, Ryuji Shiraishi, Osamu Matsubara, Yasushi Rino, Munetaka Masuda

Gan to kagaku ryoho. Cancer & chemotherapy 43 ( 12 ) 1751 - 1753 2016.11

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Adrenal metastasis from colorectal cancer occurs in the presence of multiple synchronous metastases at other sites. We report a case of heterochronous solitary adrenal metastasis from rectal cancer. A 55-year-old man underwent anterior resection with D3 lymph node dissection for rectal cancer. The pathological stage of the tumor was III b, and adjuvant chemotherapy with mFOLFOX6 was administered for 6 months. Eighteen months after surgery, abdominal computed tomography(CT) revealed right solitary adrenal metastasis. His tumor marker levels were considerably elevated; therefore, he received preoperative chemotherapy with FOLFIRI plus bevacizumab(BV). After preoperative chemotherapy, his tumor marker levels decreased, and CT and FDG-PET/CT did not uncover any other metastatic lesions. The patient was diagnosed with solitary adrenal metastasis, and right adrenalectomy was performed. Histological examination confirmed the tumor to be adrenal metastasis from rectal cancer, and the histopathological Grade was 2. The patient received adjuvant chemotherapy with mFOLFOX6, and he is alive 7 months after adrenalectomy without evidence of recurrence. Adrenalectomy is recommended for solitary adrenal metastasis from colorectal cancer. Additionally, adrenalectomy after preoperative chemotherapy is an effective strategy for patients with solitary adrenal metastasis and high tumor marker levels.

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症状発現から急速な転帰を辿った腹膜中皮腫の1例

内山護, 佐藤勉, 利野靖, 渥美陽介, 藤川善子, 林勉, 金澤周, 長谷川慎一, 玉川洋, 土田知史, 山本直人, 湯川寛夫, 大島貴, 吉川貴己, 山中正二, 益田宗孝

横浜医学 66 ( 1-2 ) 13 - 17 2015.5

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[A case of stage IV gastric cancer resected after chemotherapy with capecitabine plus cisplatin].

Yoshiko Fujikawa, Tsutomu Sato, Yasushi Rino, Mamoru Uchiyama, Yosuke Atsumi, Amane Kanazawa, Tsutomu Hayashi, Shinichi Hasegawa, Hiroshi Tamagawa, Kazuhito Tsuchida, Naoto Yamamoto, Takashi Oshima, Norio Yukawa, Takaki Yoshikawa, Munetaka Masuda

Gan to kagaku ryoho. Cancer & chemotherapy 42 ( 2 ) 221 - 3 2015.2

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A 64-year-old woman was diagnosed with Stage IV gastric cancer with lymph node and multiple liver metastases. She was treated with 6 courses of chemotherapy, in 3-week courses, with capecitabine (1,000 mg/m/(2)) plus cisplatin(80 mg/m(2)) administered for 2 weeks, followed by a drug-free week. She underwent curative total gastrectomy with D2 lymph node dissection and reconstruction by using the Roux-en-Y method. The postoperative pathological findings revealed a T3 (SE), N1M1, Stage II B tumor; the tumor was determined to be Grade 1b owing to the chemotherapeutic effect. Postoperatively, only S-1 therapy was administered, because of the development of Grade 3 hand-foot syndrome. The patient is alive 1 year and 8 months after the initial gastrectomy.

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[Curative resection of a case of advanced gastric cancer with peritoneal dissemination responding well to combination chemotherapy of docetaxel,cisplatin and S-1].

Hiroko Nemoto, Tsutomu Sato, Yasushi Rino, Mamoru Uchiyama, Yosuke Atsumi, Shinichi Hasegawa, Hiroshi Tamagawa, Takashi Oshima, Norio Yukawa, Takaki Yoshikawa, Toshio Imada, Munetaka Masuda

Gan to kagaku ryoho. Cancer & chemotherapy 40 ( 9 ) 1221 - 4 2013.9

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We report a curative resection of a case with advanced gastric cancer responding remarkably well to combination chemotherapy of docetaxel, cisplatin and S-1. The patient was a 71-year-old man with gastric cancer of Borrmann type 3 accompanied with N3. Staging laparoscopy revealed peritoneal dissemination. He was administered docetaxel intravenously at 40mg/ m2 on day 1, cisplatin intravenously at 60 mg/m2 on day 1, and S-1 orally at 80 mg/m2 on days 1 to 14. This treatment was repeated every 28 days as one course. According to gastroscope and CT findings, a significant tumor reduction was obtained after 4 courses. After 6 courses, a CT scan revealed partial response of the lymph node metastasis, and the serum CEA value was normalized. Curative total gastrectomy was performed. The histological effect of the primary lesion was judged to be grade 2. Combination chemotherapy of S-1, cisplatin and docetaxel can be effective and feasible for advanced gastric cancer.

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直腸癌術後縫合不全リスク因子の検討 ICG使用でリスク因子は変化するか?

原田龍之助, 沼田正勝, 伊豆川翔太, 鈴木佳透, 渥美陽介, 風間慶祐, 澤崎翔, 五代天偉, 菅野伸洋, 虫明寛行, 内山護, 渡邉純, 佐伯博行, 利野靖, 國崎主税, 齋藤綾

日本外科学会定期学術集会抄録集 124回 PS - 2 2024.4

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大腸癌化学療法における後方ライン治療戦略の検討

淺利昌大, 塩澤学, 井口健太, 内山護, 沼田幸司, 澤崎翔, 玉川洋, 利野靖

日本外科学会定期学術集会抄録集 124回 PS - 8 2024.4

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進行・再発大腸癌におけるFOLFOXIRI+bevacizumab治療前のmGPSは予後予測の有用な指標である

沼田幸司, 小野由香利, 井口健太, 内山護, 淺利昌大, 利野靖, 齋藤綾, 塩澤学

日本外科学会定期学術集会抄録集 124回 PS - 6 2024.4

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大腸癌治療ガイドラインに基づいた大腸癌診療とPrecision medicineの融合

井口健太, 小野由香利, 内山護, 淺利昌大, 沼田幸司, 塩澤学

日本外科学会定期学術集会抄録集 124回 PS - 7 2024.4

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胃癌肝浸潤に対して幽門側胃切除術,肝外側区域切除術を施行した1例

中山雄太, 古山和樹, 清水康一郎, 金本澪, 浦田望, 公盛啓介, 内山護, 鈴木喜裕, 利野靖, 齋藤綾

癌と化学療法 51 ( 4 ) 457 - 459 2024.4

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左腎盂癌術後に結腸転移再発を認めた1例

公盛啓介, 古山和樹, 清水康一郎, 金本澪, 中山雄太, 浦田望, 内山護, 鈴木喜裕, 利野靖, 齋藤綾

癌と化学療法 51 ( 3 ) 340 - 342 2024.3

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食道胃接合部癌術後に髄腔内播種を認めた1例

荒井智弘, 公盛啓介, 浦田望, 内山護, 鈴木喜裕, 利野靖, 齋藤綾

癌と化学療法 51 ( 1 ) 78 - 80 2024.1

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直腸腫瘍術後縫合不全に対する経肛門ドレーンの効果

渥美陽介, 沼田正勝, 風間慶祐, 澤崎翔, 原田龍之助, 伊豆川翔太, 樋口晃生, 菅野伸洋, 五代天偉, 虫明寛行, 内山護, 渡邉純, 國崎主税, 利野靖, 齋藤綾

日本内視鏡外科学会雑誌 28 ( 7 ) 2070 - 2070 2023.12

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肥満症を伴った大腸癌に対する治療戦略直腸癌肥満症例に対する開腹vs腹腔鏡・ロボット手術の短期・長期成績の検討

沼田幸司, 小野由香利, 井口健太, 内山護, 浅利昌大, 利野靖, 齋藤綾, 塩澤学

日本内視鏡外科学会雑誌 28 ( 7 ) 1632 - 1632 2023.12

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ASA3以上の高齢者大腸癌患者に対する腹腔鏡手術後合併症の危険因子の検討

澤崎翔, 風間慶祐, 沼田正勝, 大谷一貴, 加藤綾, 渥美陽介, 玉川洋, 樋口晃生, 菅野伸洋, 五代天偉, 内山護, 青山徹, 湯川寛夫, 利野靖, 齋藤綾

日本内視鏡外科学会雑誌 28 ( 7 ) 3093 - 3093 2023.12

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大腸癌手術における抗血栓薬の影響

原田龍之助, 沼田正勝, 渥美陽介, 風間慶祐, 澤崎翔, 伊豆川翔太, 鈴木佳透, 樋口晃生, 五代天偉, 菅野伸洋, 白井順也, 虫明寛行, 内山護, 渡邉純, 利野靖, 國崎主税, 齋藤綾

日本大腸肛門病学会雑誌 76 ( 9 ) A246 - A246 2023.9

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閉塞性左側結腸癌ステント症例の短期成績

伊豆川翔太, 沼田正勝, 澤崎翔, 原田龍之助, 鈴木佳透, 内山護, 渥美陽介, 風間慶祐, 渡邉純, 樋口晃生, 菅野信洋, 五代天偉, 虫明寛行, 利野靖, 國崎主税, 斎藤綾

日本大腸肛門病学会雑誌 76 ( 9 ) A219 - A219 2023.9

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ASA3以上の全身併存疾患を有する75歳以上高齢者大腸癌に対する開腹vs腹腔鏡手術の治療成績

澤崎翔, 沼田正勝, 風間慶祐, 加藤綾, 渥美陽介, 樋口晃生, 菅野伸洋, 五代天偉, 内山護, 玉川洋, 湯川寛夫, 利野靖, 齋藤綾

日本大腸肛門病学会雑誌 76 ( 9 ) A148 - A148 2023.9

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【下部】ASA3以上の全身併存疾患を有する高齢者に対する大腸癌治療の現状 ASA3以上の全身併存疾患を有する75歳以上高齢者大腸癌の手術成績

澤崎翔, 沼田正勝, 風間慶祐, 樋口晃生, 菅野伸洋, 五代天偉, 内山護, 玉川洋, 湯川寛夫, 利野靖

日本消化器外科学会総会 78回 WS16 - 2 2023.7

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ロボット直腸癌手術の中期成績

沼田正勝, 渥美陽介, 風間慶祐, 五代天偉, 鈴木紳祐, 玉川洋, 樋口晃生, 斎藤健太郎, 井口健太, 菅野伸洋, 澤崎翔, 石黒哲史, 内山護, 玉川綾子, 渡邉純, 鈴木喜裕, 佐伯博行, 湯川寛夫, 國崎主税, 利野靖

日本外科学会定期学術集会抄録集 123回 DP - 8 2023.4

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低分化腺癌・印環細胞癌・粘液癌成分を伴う結腸癌に対するD3郭清の意義

渥美陽介, 沼田正勝, 風間慶祐, 澤崎翔, 古谷晃伸, 藤野泰宏, 菅野伸洋, 内山護, 鈴木喜裕, 井口健太, 齋藤健太郎, 渡邉純, 玉川綾子, 玉川洋, 五代天偉, 樋口晃生, 佐伯博行, 湯川寛夫, 國崎主税, 利野靖

日本外科学会定期学術集会抄録集 123回 DP - 3 2023.4

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高齢者閉塞性大腸癌の検討

樋口晃生, 佐伯博行, 沼田正勝, 風間慶祐, 渥美陽介, 井口健太, 斉藤健太郎, 内山護, 岡本浩直, 片山雄介, 鈴木紳祐, 澤崎翔, 菅野伸洋, 玉川洋, 五代天偉, 湯川寛夫, 利野靖

日本外科学会定期学術集会抄録集 123回 DP - 2 2023.4

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内視鏡的治療後pT1結腸癌において,外科的切除断端長が予後に与える影響

風間慶祐, 沼田正勝, 澤崎翔, 渥美陽介, 福田桃子, 石黒哲史, 朱美和, 杉山敦彦, 井口健太, 斎藤健太郎, 神尾一樹, 青山徹, 玉川洋, 湯川寛夫, 樋口晃生, 佐伯博行, 五代天偉, 菅野伸洋, 内山護, 利野靖

日本外科学会定期学術集会抄録集 123回 DP - 8 2023.4

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胃癌肝浸潤に対して幽門側胃切除術,肝外側区域切除術を施行した一例

中山雄太, 公盛啓介, 金本澪, 内山護, 鈴木喜裕, 利野靖

日本胃癌学会総会記事 95回 369 - 369 2023.2

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胃神経内分泌癌の転移再発に対してイリノテカン/シスプラチン療法を施行した2例

公盛啓介, 金本澪, 中山雄太, 内山護, 鈴木喜裕, 利野靖

日本胃癌学会総会記事 95回 415 - 415 2023.2

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食道胃接合部癌術後に髄膜内播種を認めた1例

荒井智弘, 公盛啓介, 浦田望, 内山護, 鈴木喜裕

日本臨床外科学会雑誌 83 ( 増刊 ) S385 - S385 2022.10

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左腎盂癌術後に結腸転移再発を認めた1例

公盛啓介, 金本澪, 中山雄太, 浦田望, 内山護, 鈴木喜裕

日本臨床外科学会雑誌 83 ( 増刊 ) S439 - S439 2022.10

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大腸癌肝転移巣におけるセリンプロテアーゼPRSS22の発現と肝転移切除後再発の相関

内山護, 塩澤学, 菊池慶司, 宮城洋平, 中村圭靖, 吉原光代, 横瀬智之, 利野靖, 益田宗孝

日本消化器外科学会総会 75回 P200 - 1 2020.12

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肝転移を伴うStageIV大腸癌に対する肝切除後早期再発の検討

加藤綾, 塩澤学, 内山護, 岡本浩直, 高村卓志, 佐藤純人, 菅野伸洋, 利野靖, 益田宗孝

日本消化器外科学会総会 75回 P179 - 5 2020.12

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大腸手術(悪性)

佐藤純人, 塩澤学, 菅野伸洋, 加藤綾, 内山護, 岡本浩直, 高村卓志, 大島貴, 利野靖, 益田宗孝

日本消化器外科学会雑誌 53 ( Suppl.2 ) 203 - 203 2020.11

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当科におけるMSI-Highを有する進行再発大腸癌の現状と治療経験

佐藤純人, 塩澤学, 菅野伸洋, 加藤綾, 内山護, 高村卓志, 岡本浩直, 井口健太, 額田卓, 大島貴, 利野靖, 益田宗孝

日本大腸肛門病学会雑誌 73 ( 9 ) A182 - A182 2020.9

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高齢者大腸癌手術におけるD3リンパ節郭清の意義

淺利昌大, 青山徹, 公盛啓介, 内山護, 前澤幸男, 澤崎翔, 沼田正勝, 玉川洋, 佐藤勉, 大佛智彦, 谷和行, 湯川寛夫, 利野靖, 益田宗孝

癌と化学療法 47 ( 2 ) 259 - 261 2020.2

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腹腔鏡下右半結腸切除術におけるSMAに沿ったD3郭清のコツ

菅野伸洋, 塩澤学, 佐藤純人, 加藤綾, 内山護, 高村卓志, 岡本浩直, 利野靖, 益田宗孝

日本内視鏡外科学会雑誌 24 ( 7 ) SF019 - 2 2019.12

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中結腸根リンパ節(No 223)転移を伴う結腸癌の治療成績

佐藤純人, 塩澤学, 菅野伸洋, 風間慶祐, 加藤綾, 内山護, 森永聡一郎, 大島貴, 利野靖, 益田宗孝

日本消化器外科学会雑誌 52 ( Suppl.2 ) 140 - 140 2019.11

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実臨床におけるFOLFOXIRI+Bevacizumabの治療成績と、今後の課題

風間慶祐, 塩澤学, 岡本浩直, 内山護, 加藤綾, 佐藤純人, 菅野信洋, 沼田正勝, 青山徹, 玉川洋, 湯川寛夫, 利野靖, 益田宗孝

日本癌治療学会学術集会抄録集 57回 P19 - 2 2019.10

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局所進行直腸癌に対する術前FOLFOXIRI療法の短期成績

菅野伸洋, 塩澤学, 佐藤純人, 加藤綾, 高村卓志, 内山護, 岡本浩直, 益田宗孝

日本癌治療学会学術集会抄録集 57回 O40 - 4 2019.10

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FOLFIRI+Aflibercept併用療法の治療効果及び忍容性に対する実臨床における検討

高村卓志, 菅野伸洋, 佐藤純人, 加藤綾, 内山護, 岡本浩直, 塩澤学

日本癌治療学会学術集会抄録集 57回 P79 - 3 2019.10

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直腸肛門部悪性黒色腫の術後鼠径リンパ節再発に対し切除及びNivolumabによる術後補助化学療法を施行した1例

岡本浩直, 塩澤学, 菅野伸洋, 内山護, 加藤綾, 高村卓志, 佐藤純人, 利野靖, 益田宗孝

日本臨床外科学会雑誌 80 ( 増刊 ) 850 - 850 2019.10

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StageIV大腸癌に対する原発巣切除の意義

加藤綾, 塩澤学, 内山護, 岡本浩直, 高村卓志, 佐藤純人, 菅野伸洋, 利野靖, 益田宗孝

日本臨床外科学会雑誌 80 ( 増刊 ) 622 - 622 2019.10

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術後合併症で苦しんだ症例2(下部消化管) 側方リンパ節郭清後の難治性側方腔リンパ漏に対し、OK432を用いた癒着療法が奏功した一例

菅野伸洋, 塩澤学, 佐藤純人, 加藤綾, 高村卓史, 内山護, 岡本浩直, 利野靖, 益田宗孝

日本臨床外科学会雑誌 80 ( 増刊 ) 414 - 414 2019.10

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大腸癌に対するFOLFOXIRI療法中に高アンモニア血症を認めた2例

加藤綾, 塩澤学, 内山護, 佐藤純人, 菅野伸洋, 利野靖, 益田宗孝

日本大腸肛門病学会雑誌 72 ( 9 ) A187 - A187 2019.9

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Triplet regimenの臨床的位置づけと副作用のマネージメント実臨床におけるFOLFOXIRI+Bevacizumabの治療成績と、今後の課題

風間慶祐, 塩澤学, 内山護, 加藤綾, 佐藤純人, 菅野信洋, 沼田正勝, 青山徹, 玉川洋, 湯川寛夫, 大島貴, 利野靖, 益田宗孝

日本大腸肛門病学会雑誌 72 ( 9 ) A75 - A75 2019.9

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当科における直腸NET手術切除症例の短期治療成績の検討

内山護, 加藤綾, 佐藤純人, 菅野伸洋, 塩澤学, 利野靖

日本大腸肛門病学会雑誌 72 ( 9 ) A179 - A179 2019.9

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横行結腸癌に対する腹腔鏡下CME

菅野伸洋, 塩澤学, 内山護, 加藤綾, 佐藤純人, 利野靖, 益田宗孝

日本大腸肛門病学会雑誌 72 ( 9 ) A154 - A154 2019.9

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大腸癌多発肺肝転移に対し手術、化学療法およびラジオ波焼灼療法の集学的治療で長期CRを得られた1例

佐藤純人, 塩澤学, 菅野伸洋, 加藤綾, 内山護, 風間慶祐, 大島貴, 利野靖, 益田宗孝

日本大腸肛門病学会雑誌 72 ( 9 ) A220 - A220 2019.9

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腹腔鏡下S状結腸切除後にポートサイトヘルニアを発症した1例

小口翼, 山本弥生, 阿武和, 吉田哲雄, 佐藤純人, 塩澤学, 内山護

臨床放射線 64 ( 9 ) 1181 - 1184 2019.8

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誌上ディベート(第16回) 右側結腸癌に対する郭清範囲 SMV左縁vs.SMA左縁 SMA左縁の立場から

塩澤学, 菅野伸洋, 佐藤純人, 加藤綾, 内山護, 岡本浩直, 高村卓志

消化器外科 42 ( 9 ) 1375 - 1380 2019.8

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右肺底動脈体動脈起始症に対して胸腔鏡下右肺下葉区域切除術を施行した一例

船越薫子, 山仲一輝, 白石龍二, 谷和行, 羽鳥慎祐, 白井順也, 川邉泰一, 内山護, 中村生, 河原慎之輔

神奈川医学会雑誌 46 ( 2 ) 188 - 188 2019.7

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壁深達度T1のstageIII大腸癌の治療成績

風間慶祐, 塩澤学, 内山護, 加藤綾, 佐藤純人, 菅野伸洋, 大島貴, 利野靖, 益田宗孝

日本大腸肛門病学会雑誌 72 ( 5 ) 362 - 362 2019.5

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当院におけるアフリベルセプトの使用経験

菅野伸洋, 塩澤学, 佐藤純人, 加藤綾, 内山護, 利野靖, 益田宗孝

日本外科学会定期学術集会抄録集 119回 SF - 5 2019.4

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腹腔鏡下大腸切除術におけるハグユーバックを用いた体位固定法

加藤綾, 塩澤学, 内山護, 佐藤純人, 菅野伸洋, 利野靖, 益田宗孝

日本内視鏡外科学会雑誌 23 ( 7 ) OS35 - 3 2018.12

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Complete mesocoloic excisionを意識した腹腔鏡下下行結腸切除術

菅野伸洋, 塩澤学, 佐藤純人, 加藤綾, 内山護, 利野靖, 益田宗孝

日本内視鏡外科学会雑誌 23 ( 7 ) OS4 - 4 2018.12

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腹腔鏡下手術後の5mmポート孔に生じたヘルニア嵌頓の1例

内山護, 加藤綾, 佐藤純人, 菅野伸洋, 塩澤学

日本内視鏡外科学会雑誌 23 ( 7 ) DP101 - 3 2018.12

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当院における大腸癌2次治療としてのFOLFIRI+Ramucirumabの成績

風間慶祐, 塩澤学, 内山護, 加藤綾, 佐藤純人, 菅野伸洋, 大島貴, 利野靖, 益田宗孝

日本癌治療学会学術集会抄録集 56回 P19 - 5 2018.10

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局所進行直腸癌に対する術前FOLFOXIRI療法の短期成績

菅野伸洋, 塩澤学, 佐藤純人, 風間慶祐, 加藤綾, 内山護, 益田宗孝

日本大腸肛門病学会雑誌 71 ( 抄録号 ) A165 - A165 2018.9

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StageII直腸癌における再発危険因子の検討

加藤綾, 塩澤学, 内山護, 佐藤純人, 菅野伸洋, 利野靖, 益田宗孝

日本大腸肛門病学会雑誌 71 ( 抄録号 ) A246 - A246 2018.9

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Sclerosing angiomatoid nodular transformation(SANT)の1例

新里稔, 内山護, 白井順也, 串田好宏, 淺利昌大, 山仲一輝, 大佛智彦, 羽鳥慎祐, 谷和行, 白石龍二, 松原修, 利野靖, 益田宗孝

神奈川医学会雑誌 45 ( 2 ) 177 - 177 2018.7

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腹腔鏡下胆嚢摘出術を施行した胆嚢管走行異常の1例

内山護, 羽鳥慎祐, 串田好宏, 川邉泰一, 白井順也, 山仲一輝, 谷和行, 利野靖, 益田宗孝

日本内視鏡外科学会雑誌 22 ( 7 ) EP205 - 09 2017.12

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結腸膀胱瘻により会陰部壊死性筋膜炎をきたした1例

串田好宏, 谷和行, 中村生, 内山護, 川邉泰一, 白井順也, 山仲一輝, 羽鳥慎祐, 白石龍二, 益田宗孝

日本外科感染症学会雑誌 14 ( 5 ) 650 - 650 2017.10

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当科における男性乳癌の11例

中村生, 谷和行, 串田好宏, 内山護, 川邉泰一, 白井順也, 山仲一輝, 羽鳥慎佑, 白石龍二

日本臨床外科学会雑誌 78 ( 増刊 ) 633 - 633 2017.10

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Streptococcus bovisによる感染性心内膜炎を契機に発見したS状結腸癌の一例

稲葉俊介, 淺利昌大, 大佛智彦, 亀田洋平, 渡邊勇人, 内山護, 土田知史, 松浦仁, 山仲一輝, 谷和行, 白石龍二

神奈川医学会雑誌 44 ( 2 ) 201 - 201 2017.7

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多発肺腺癌の臨床および分子生物学的解析

山仲一輝, 白石龍二, 谷和行, 大佛智彦, 羽鳥慎祐, 白井順也, 淺利昌大, 内山護, 串田好宏, 中村生, 神靖人, 松原修, 諸星隆夫, 津浦幸夫

共済医報 66 ( 2 ) 207 - 211 2017.5

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人工肛門造設患者における術前ストーマサイトマーキングと手技獲得期間との関連性

淺利昌大, 内山護, 串田好宏, 白井順也, 山仲一輝, 羽鳥慎祐, 大佛智彦, 谷和行, 白石龍二, 利野靖, 益田宗孝

日本外科学会定期学術集会抄録集 117回 PS - 1 2017.4

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人工肛門造設患者における術前ストーマサイトマーキングと手技獲得期間との関連性

淺利昌大, 内山護

日本ストーマ・排泄リハビリテーション学会誌 33 ( 1 ) 190 - 190 2017.1

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当院の緊急手術におけるストーマ関連合併症のリスク因子の検討

内山護, 淺利昌大

日本ストーマ・排泄リハビリテーション学会誌 33 ( 1 ) 179 - 179 2017.1

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短期入院時代におけるストーマ造設と管理ストーマ手技習得における介助者を要する患者背景および手技習得期間の検討

淺利昌大, 内山護

日本ストーマ・排泄リハビリテーション学会誌 33 ( 1 ) 88 - 88 2017.1

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当院における腹腔鏡下ヘルニア修復術(TAPP)導入の初期成績の検討

渡邊勇人, 土田和史, 亀田洋平, 内山護, 淺利昌大, 松浦仁, 山仲一輝, 大佛智彦, 白石龍二, 谷和行, 佐伯博行, 松川博史, 利野靖, 益田宗孝

日本内視鏡外科学会雑誌 21 ( 7 ) OS25 - 2 2016.12

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化学療法後に切除した直腸癌術後孤立性副腎転移の1例

土田知史, 渡邊勇人, 亀田洋平, 内山護, 淺利昌大, 松浦仁, 山仲一輝, 大佛智彦, 谷和行, 白石龍二, 松原修, 利野靖, 益田宗孝

癌と化学療法 43 ( 12 ) 1751 - 1753 2016.11

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腹腔鏡下虫垂切除術 3ポートで行う虫垂断端埋没法

白井順也, 串田好宏, 内山護, 浅利昌大, 山仲一輝, 大佛智彦, 羽鳥慎祐, 谷和行, 白石龍二, 利野靖, 益田宗孝

日本臨床外科学会雑誌 77 ( 増刊 ) 778 - 778 2016.10

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人工肛門造設患者における術前ストーマサイトマーキングと手技獲得期間との関連性

淺利昌大, 串田好宏, 内山護, 白井順也, 山仲一輝, 大佛智彦, 羽鳥慎祐, 谷和行, 白石龍二, 利野靖, 益田宗孝

日本臨床外科学会雑誌 77 ( 増刊 ) 574 - 574 2016.10

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Sclerosing angiomatoid nodular transformation(SANT)の1例

内山護, 串田好宏, 淺利昌大, 白井順也, 山仲一輝, 大佛智彦, 羽鳥慎祐, 谷和行, 白石龍二, 松原修, 利野靖, 益田宗孝

日本臨床外科学会雑誌 77 ( 増刊 ) 963 - 963 2016.10

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胸壁腫瘍との鑑別が困難だった肺扁平上皮癌の1切除例

山仲一輝, 谷和行, 白石龍二, 大佛智彦, 羽鳥慎祐, 白井順也, 淺利昌大, 内山護, 串田好宏, 亀田洋平

日本臨床外科学会雑誌 77 ( 増刊 ) 924 - 924 2016.10

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Streptococcus bovisによる感染性心内膜炎を契機に発見されたS状結腸癌の1例

稲葉俊介, 大佛智彦, 淺利昌大, 渡邊勇人, 亀田洋平, 内山護, 土田知史, 松浦仁, 山仲一輝, 白石龍二, 谷和行

日本臨床外科学会雑誌 77 ( 増刊 ) 1005 - 1005 2016.10

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純粋型乳腺扁平上皮癌の一例

串田好宏, 谷和行, 白石龍二, 羽鳥慎祐, 大佛智彦, 山仲一輝, 白井順也, 淺利昌大, 内山護, 松原修, 利野靖, 益田宗孝

日本臨床外科学会雑誌 77 ( 増刊 ) 967 - 967 2016.10

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Streptococcus bovisによる感染性心内膜炎を契機に発見されたS状結腸癌の1例

稲葉俊介, 土田知史, 淺利昌大, 大佛智彦, 亀田洋平, 渡邊勇人, 内山護, 松浦仁, 山仲一輝, 白石龍二, 谷和行, 檮木優哉, 大西祐子

神奈川医学会雑誌 43 ( 2 ) 226 - 230 2016.7

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乳癌術後乳頭部転移の1例

松浦仁, 亀田洋平, 渡邊勇人, 内山護, 淺利昌大, 土田知史, 大佛智彦, 山仲一輝, 谷和行, 白石龍二

日本乳癌学会総会プログラム抄録集 24回 561 - 561 2016.6

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乳癌腸間膜・腹膜転移により腸閉塞をきたした1例

沼田幸司, 内山護, 四元宏和, 後藤直樹, 松浦仁, 川本昌和, 山本直人, 利野靖, 益田宗孝, 田邉浩悌

日本臨床外科学会雑誌 76 ( 増刊 ) 1093 - 1093 2015.10

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再発鼠径ヘルニアに対し、腹腔鏡下ヘルニア修復術を施行した1例

渡邊勇人, 亀田洋平, 内山護, 淺利昌大, 松浦仁, 土田知史, 山仲一輝, 大佛智彦, 白石龍二, 谷和行, 原田浩, 利野靖, 益田宗孝

日本臨床外科学会雑誌 76 ( 増刊 ) 1011 - 1011 2015.10

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腹腔鏡下切除した後腹膜平滑筋肉腫の1例

天野新也, 佐藤勉, 利野靖, 内山護, 渥美陽介, 山内美帆子, 藤川善子, 長谷川慎一, 玉川洋, 山本直人, 大島貴, 今田敏夫, 益田宗孝

日本外科系連合学会誌 40 ( 4 ) 828 - 832 2015.8

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急速な増大を呈した嚢胞内成分を主体とした乳頭腺管癌の1例

松浦仁, 田邉浩悌, 川本昌和, 後藤直樹, 沼田幸司, 内山護, 上杉佳世

日本乳癌学会総会プログラム抄録集 23回 701 - 701 2015.7

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超高齢者大腸癌手術の術後合併症予測におけるCharlson Comorbidity IndexとE-PASS(PRS)の有用性

沼田幸司, 内山護, 後藤直樹, 松浦仁, 川本昌和, 山本直人, 利野靖, 益田宗孝, 田辺浩悌

日本消化器外科学会総会 70回 RS - 1 2015.7

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Capecitabine+CDDP療法が奏効し切除し得たStage IV進行胃癌の1例

藤川善子, 佐藤勉, 利野靖, 内山護, 渥美陽介, 金澤周, 林勉, 長谷川慎一, 玉川洋, 土田知史, 山本直人, 大島貴, 湯川寛夫, 吉川貴己, 益田宗孝

癌と化学療法 42 ( 2 ) 221 - 223 2015.2

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多発結腸転移を来した胃癌の一切除例

内山護, 稲福賢司, 後藤直樹, 川本昌和, 羽鳥慎祐, 田邉浩悌

日本臨床外科学会雑誌 75 ( 12 ) 3412 - 3412 2014.12

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多発結腸転移を来たした胃癌の一切除例

内山護, 沼田幸司, 後藤直樹, 川本昌和, 田邉浩悌, 利野靖, 益田宗孝

日本臨床外科学会雑誌 75 ( 増刊 ) 745 - 745 2014.10

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穿孔性腹膜炎により緊急手術を施行した腹膜原発性漿液性乳頭状腺癌の1例

小林洋樹, 内山護, 沼田幸司, 後藤直樹, 川本昌和, 田邊浩悌

日本臨床外科学会雑誌 75 ( 増刊 ) 859 - 859 2014.10

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Docetaxel/Cisplatin/S-1併用療法が奏効し根治切除を行ったStage IV胃癌の1切除例

根本寛子, 佐藤勉, 利野靖, 内山護, 渥美陽介, 長谷川慎一, 玉川洋, 大島貴, 湯川寛夫, 吉川貴己, 今田敏夫, 益田宗孝

癌と化学療法 40 ( 9 ) 1221 - 1224 2013.9

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2013&ichushi_jid=J00296&link_issn=&doc_id=20130920400020&doc_link_id=%2Fab8gtkrc%2F2013%2F004009%2F021%2F1221-1224%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2013%2F004009%2F021%2F1221-1224%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
巨大冠動脈瘤に対して手術を行った一例

合田真海, 井元清隆, 内田敬二, 軽部義久, 安恒亨, 長知樹, 梅田悦嗣, 内山護, 益田宗孝

日本胸部外科学会関東甲信越地方会要旨集 ( 162回 ) 16 - 16 2013.6

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僧帽弁前尖逸脱症に合併した心室頻拍の一例

内山護, 井元清隆, 内田敬二, 輕部義久, 安恒亨, 長知樹, 梅田悦嗣, 合田真海, 益田宗孝

日本胸部外科学会関東甲信越地方会要旨集 ( 162回 ) 24 - 24 2013.6

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当院における孤立性腸骨動脈瘤の検討

長知樹, 井元清隆, 内田敬二, 軽部義久, 安恒亨, 梅田悦嗣, 合田真海, 内山護, 益田宗孝

日本血管外科学会雑誌 22 ( 2 ) 296 - 296 2013.4

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急性・慢性B型解離における治療戦略の進歩 TEVARの位置づけ B型急性大動脈解離における治療戦略の進歩 TEVARの位置づけ

輕部義久, 井元清隆, 内田敬二, 安恒亨, 長知樹, 梅田悦嗣, 合田真海, 内山護, 益田宗孝

日本血管外科学会雑誌 22 ( 2 ) 200 - 200 2013.4

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IFU遵守の有無から検討したEVARの中期成績

長知樹, 井元清隆, 内田敬二, 軽部義久, 安恒亨, 梅田悦嗣, 合田真海, 内山護, 益田宗孝

日本血管外科学会雑誌 22 ( 2 ) 410 - 410 2013.4

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Capecitabine+Cisplatin療法が奏効し切除し得たStage IV進行胃癌の1例

藤川善子, 佐藤勉, 内山護, 渥美陽介, 根本寛子, 長谷川慎一, 玉川洋, 金澤周, 土田知史, 大島貴, 湯川寛夫, 吉川貴己, 利野靖, 益田宗孝

神奈川医学会雑誌 40 ( 1 ) 74 - 74 2013.3

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たこつぼ型心筋症による心室中隔穿孔に対する一手術例

内山護, 井元清隆, 内田敬二, 輕部義久, 安恒亨, 長知樹, 梅田悦嗣, 合田真海, 益田宗孝

日本胸部外科学会関東甲信越地方会要旨集 ( 161回 ) 15 - 15 2013.3

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感染性合併症は食道胃接合部腺癌根治切除例の長期予後に影響を及ぼすか

長谷川慎一, 吉川貴己, 内山護, 根本寛子, 渥美陽介, 藤川善子, 藤井慶太, 玉川洋, 山本健嗣, 佐藤勉, 湯川寛夫, 利野靖, 益田宗孝, 小野秀高, 土田知史, 大島貴, 國崎主税, 藤川寛人, 白井順也, 長晴彦, 円谷彰

日本外科学会雑誌 114 ( 臨増2 ) 763 - 763 2013.3

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早期胃癌に対する色素法単独でのセンチネルリンパ節生検の有用性・適応の検討

佐藤勉, 利野靖, 渥美陽介, 天野新也, 山内美帆子, 藤川善子, 内山護, 金澤周, 長谷川慎一, 玉川洋, 土田知史, 山本直人, 大島貴, 湯川寛夫, 吉川貴己, 今田敏夫, 益田宗考

日本外科学会雑誌 114 ( 臨増2 ) 462 - 462 2013.3

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食道胃接合部癌に対する治療戦略特にリンパ節郭清を中心に食道浸潤胃癌の経裂孔的下縦隔郭清

利野靖, 湯川寛夫, 佐藤勉, 玉川洋, 長谷川慎一, 藤川善子, 山内美帆子, 渥美陽介, 内山護, 大島貴, 土田知史, 金澤周, 吉川貴己, 益田宗孝, 今田敏夫

日本胃癌学会総会記事 85回 210 - 210 2013.2

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Capecitabine+Cisplatin療法が奏効し切除し得たStageIV進行胃癌の1例

藤川善子, 佐藤勉, 内山護, 渥美陽介, 根本寛子, 長谷川慎一, 玉川洋, 金澤周, 土田知史, 大島貴, 湯川寛夫, 吉川貴己, 利野靖, 益田宗孝

日本胃癌学会総会記事 85回 382 - 382 2013.2

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腹腔鏡下に切除した成人横行結腸間膜リンパ管腫の1例

渥美陽介, 佐藤勉, 内山護, 根本寛子, 藤川善子, 長谷川慎一, 玉川洋, 金澤周, 土田知史, 大島貴, 湯川寛夫, 利野靖, 益田宗孝

日本内視鏡外科学会雑誌 17 ( 7 ) 423 - 423 2012.12

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早期胃癌に対する腹腔鏡下胃局所切除に関する検討

佐藤勉, 利野靖, 湯川寛夫, 内山護, 渥美陽介, 根本寛子, 藤川寛人, 藤川善子, 金澤周, 長谷川慎一, 玉川洋, 土田知史, 大島貴, 吉川貴己, 今田敏夫, 益田宗孝

日本内視鏡外科学会雑誌 17 ( 7 ) 453 - 453 2012.12

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症状発現から急速な転機をたどった腹膜中皮腫の1例

内山護, 利野靖, 湯川寛夫, 渥美陽介, 根本寛子, 藤川善子, 金澤周, 長谷川慎一, 土田知史, 佐藤勉, 大島貴, 今田敏夫, 益田宗孝

日本臨床外科学会雑誌 73 ( 増刊 ) 1041 - 1041 2012.10

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腰部硬膜外Hemangiopericytoma術後、両側乳房転移の1例

山中隆司, 利野靖, 内山護, 小島いずみ, 山中歩, 向橋知江, 藤井慶太, 中山博貴, 菅沼伸康, 松浦仁, 山本健嗣, 松津賢一, 吉田明, 清水哲, 益田宗孝

日本臨床外科学会雑誌 73 ( 増刊 ) 1014 - 1014 2012.10

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