Updated on 2025/08/30

写真a

 
Haruka Yoshii
 
Organization
YCU Medical Center Oral and Maxillofacial Surgery/Orthodontics Assistant Professor
Title
Assistant Professor
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Degree

  • Doctor of Philosophy ( 2022.3   Yokohama City University )

Research Interests

  • SIRT6、口腔癌

Education

  • Yokohama City University   Graduate School of Medical Life Science

    - 2022.3

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    Country： Japan

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  • The University of Tokushima   Faculty of Dentistry   School of Dentistry

    2007.4 - 2013.3

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    Country： Japan

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Research History

  • Yokohama City University Medical Center   Hospital Dentistry/Oral and Maxillofacial Surgery/Orthodontics   Assistant Professor

    2024.4

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  • Yokohama City University

    2020.4 - 2024.3

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  • National Hospital Organization, Yokohama Medical Center

    2017.4 - 2020.3

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  • 横浜市立大学附属病院 歯科・口腔外科   シニアレジデント

    2015.4 - 2017.3

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  • 横浜市立大学附属病院 歯科・口腔外科   研修医

    2013.4 - 2015.3

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Professional Memberships

Papers

  • Involvement of Oral Microbiome in the Development of Oral Malignancy Reviewed

    Hitoshi Isono, Shintaro Nakajima, Satoshi Watanabe, Aya K Takeda, Haruka Yoshii, Ami Shimoda, Hisao Yagishita, Kenji Mitsudo, Mitomu Kioi

    Cancers   17 ( 4 )   632 - 632   2025.2

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    Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Objective: This study aimed to identify periodontal pathogens involved in the onset and progression of OSCC. Methods: Saliva samples were collected from 112 patients without oral mucosal diseases (OMDs) as controls; 36 patients with oral potentially malignant disorders (OPMDs); and 104 patients with OSCC. Periodontal examinations were performed on all patients. Endpoint PCR was performed for seven species of oral pathogens. The 16S rRNA analysis was performed using 20 DNA samples from each group. Results: Periodontitis tended to worsen in the OMDs group compared to the control group. The number of oral bacteria was significantly higher in the OSCC group than in the other groups. The detection rates of P. gingivalis and Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) were significantly higher in the OSCC group than those in the control group. From 16S rRNA analysis, the relative abundance of Prevotella buccae and intermedia was significantly higher in OSCC than in the control. Moreover, LPS derived from P. gingivalis contributes to the early development of oral epithelial precancerous lesions and carcinomas in mice. Conclusions: Specific periodontal pathogens are present in the oral cavities of patients with OPMDs and OSCC, and changes in the bacterial flora due to their presence may contribute to the onset and progression of OMDs.

    DOI： 10.3390/cancers17040632

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  • Nasopalatine duct cyst following Le Fort I osteotomy: A case report Reviewed

    Hikaru Takasu, Yuichiro Hayashi, Haruka Yoshii, Hiroki Miyagishima, Yoshiaki Inayama, Makoto Hirota, Kenji Mitsudo

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2025.1

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ajoms.2025.01.013

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  • Pathological mandibular fractures following idiopathic resorption of bilateral mandibular rami and coronoid processes Reviewed

    Haruka Yoshii, Toshinori Iwai, Satomi Sugiyama

    Journal of Dental Sciences   19   656 - 658   2023.9

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    Authorship：Lead author  

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  • The Expression of SIRT6 Is Associated With Treatment Outcome in Elder Patients With Oral Cancer Reviewed

    HARUKA YOSHII, KAZUMASA SEKIHARA, YUKA IDETA, SHINTARO NAKAJIMA, IKUMA KATO, MAKIKO OKUBO-SATO, KEI SUGIURA, KENJI MITSUDO, MITOMU KIOI

    Anticancer Research   42 ( 8 )   3815 - 3823   2022.8

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    Authorship：Lead author   Language：English   Publishing type：Doctoral thesis   Publisher：Anticancer Research USA Inc.  

    DOI： 10.21873/anticanres.15872

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  • Intra-oral minor salivary gland tumors: A pathological study of 131 cases in the Japanese population Reviewed

    Yuichiro Hayashi, Toshinori Iwai, Satomi Sugiyama, Kohei Osawa, Haruka Yoshii, Shuhei Minamiyama, Hiroaki Kitajima, Makoto Hirota, Kenji Mitsudo

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   31 ( 6 )   424 - 427   2019.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ajoms.2019.06.007

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  • Retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia and cetuximab for carcinoma of the buccal mucosa with N3 lymph node metastasis: a case report Reviewed

    Kaname Sakuma, Toshiyuki Koizumi, Kenji Mitsudo, Jun Ueda, Yuichiro Hayashi, Toshinori Iwai, Makoto Hirota, Mitomu Kioi, Haruka Yoshii, Hisashi Kaizu, Masaharu Hata, Akira Tanaka, Iwai Tohnai

    Oral Radiology   35 ( 1 )   77 - 83   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    We herein report a case of squamous cell carcinoma of the buccal mucosa with N3 cervical lymph node metastasis in a 63-year-old man. The patient was treated with combination therapy comprising radiotherapy (2 Gy/day, total of 70 Gy), superselective intra-arterial chemotherapy via a superficial temporal artery (docetaxel, total of 70 mg/m2 and cisplatin, total of 175 mg/m2), cetuximab (initial dose of 400 mg/m2 with subsequent weekly doses of 250 mg/m2 intravenously), and four sessions of hyperthermia for cervical lymph node metastases. The patient responded well to the therapy, with a complete response of the primary tumor. Radical neck dissection was performed with reconstructive surgery, including resection of the overlying skin. A pathologic complete response was achieved for the N3 and all other cervical lymph node metastases. The patient showed no evidence of recurrence in the 3 years following treatment. Based on the findings in the present case, the use of retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia and cetuximab seems to be a promising modality for patients with N3 cervical lymph node metastasis of oral cancer.

    DOI： 10.1007/s11282-018-0319-y

    PubMed

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    Other Link： http://link.springer.com/content/pdf/10.1007/s11282-018-0319-y.pdf

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MISC

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Research Projects

  • 口腔癌の早期発見・予後予測マーカーとしてのSIRT6の可能性と悪性度への関与

    Grant number：23K16161  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  若手研究

    吉井 悠

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    Authorship：Principal investigator 

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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