記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND/AIM: Cervical lymph node metastasis worsens oral cancer prognosis. Cancer cells with high metastatic ability can delay or resist apoptosis and survive in the floating condition during circulation. The involved genes and pathways in this process remain largely unknown. This study aimed to establish an oral cancer cell line adapted to suspension culture by in vitro selection and perform gene expression analysis. MATERIALS AND METHODS: The oral cancer cell subline adapted to suspension culture was isolated by in vitro selection from the oral cancer cell line, HSC-3. The transcriptome profiles of HSC-3 and its subline were compared using gene expression microarrays. Gene Ontology (GO) enrichment analysis, Gene Set Enrichment Analysis (GSEA), and Ingenuity Pathway Analysis (IPA) were performed to predict the involved pathways and molecules in cancer progression. RESULTS: The subline was designated as HSC-3S5 The cellular viability of HSC-3S5 cells at the suspension culture was higher than that of HSC-3 cells. A total of 961 genes were differentially expressed between HSC-3 and HSC-3S5 cells under the threshold cut-off (FDR-adjusted p-value of <0.05 and absolute fold change of >1.5). GO terms, such as growth regulation, were enriched in the DEGs. GSEA revealed the association between the DEGs and significant gene sets, including metastasis and stemness. IPA predicted that the proliferation-related pathways were enhanced while the apoptotic pathway was inhibited in HSC-3S5 cells compared to HSC-3 cells. CONCLUSION: Our transcriptome analysis revealed several potentially activated pathways and molecules in the floating-adapted oral cancer cells and indicated molecular implications for cancer progression.

DOI： 10.21873/anticanres.16578

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: The incidence of multicentric oral cancer is increasing. However, treatment encounters difficulty if each tumor needs to be treated simultaneously. The objective of this clinical case report is to highlight the effect of concurrent chemoradiotherapy with retrograde superselective intra-arterial infusion combined with systemic administration of cetuximab on synchronous multifocal oral squamous cell carcinomas. CASE PRESENTATION: A 70-year-old man presented to the hospital with multiple tumors and oral pain. Three independent tumors were found in the right dorsal tongue, left edge of the tongue, and left lower lip. Based on the characteristic appearance of the lesions and further evaluation, clinical diagnoses of right tongue cancer "T3", left tongue cancer "T2" and lower left lip cancer "T1", N2cM0 were made. Treatment was initiated with systemic administration of cetuximab, followed by intra-arterial chemoradiotherapy. Treatment results were complete response on all three local lesions, and left neck dissection was performed following the initial treatment. The patient showed no evidence of recurrence during the 4 years follow-up period. CONCLUSIONS: This novel combination treatment seems to be a promising strategy for patients with synchronous multifocal oral squamous cell carcinoma.

DOI： 10.1186/s13014-023-02282-9

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Anticancer Research USA Inc.  

DOI： 10.21873/cgp.20365

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The aim of this study was to evaluate the therapeutic efficacy and safety of proton beam therapy combined with retrograde intra-arterial infusion chemotherapy in elderly patients with locally advanced oral cancer. Between February 2009 and October 2019, 42 oral cancer patients aged ≥75 years were treated with this therapy. Median age was 80 years (range 75-90 years) and the median follow-up duration was 39 months (range 2-106 months). Of the 42 patients, 34 (81%) were diagnosed with stage IV cancer. The 3-year overall survival, local control, progression-free survival, and disease-specific survival rates were 56%, 69%, 32%, and 67%, respectively. Regarding acute toxicities, grade 3 neutropenia was observed in six patients (14%), anaemia in five (12%), acute kidney injury in one (2%), and oral mucositis in 18 (42%). Late toxicities of grade 3 were observed in seven patients: dysphagia in six (14%) and osteonecrosis of the jaw in one (2%). This study showed that proton beam therapy combined with retrograde intra-arterial infusion chemotherapy was effective for elderly patients with oral cancer, and toxicities were tolerable and manageable. The study findings suggest that this therapy is a potential treatment option for elderly oral cancer patients with difficulty in surgery and systemic chemotherapy.

DOI： 10.1016/j.ijom.2022.01.014

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

症例は30歳代女性で、かかりつけ歯科医院で撮影したパノラマエックス線写真で上顎右側第三大臼歯部の透過像を指摘され、精査加療目的に当科紹介受診となった。局所麻酔下に生検を施行し歯原性嚢胞の診断を得て、全身麻酔下に右側上顎骨嚢胞摘出術を施行した。上顎右側第二大臼歯近心頬側に縦切開を加え、上顎右側第二大臼歯頬側歯頸部切開、遠心切開と連続させ粘膜骨膜弁を形成した。周囲の骨を削除したところ、上顎右側第三大臼歯を取り囲む嚢胞性病変が確認でき、上顎右側第三大臼歯を抜歯後、嚢胞を摘出した。病理組織学的診断では正角化性歯原性嚢胞であった。現在、術後約5ヵ月が経過しているが再発を示唆する所見は認められず経過良好である。

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

We report a rare case of schwannoma arising from the sublingual glandular branch of the lingual nerve radiologically masquerading as sublingual gland tumor. A 42-year-old female was referred to our department with a painless swelling in the left submandibular region. Contrast-enhanced computed tomography showed a well-circumscribed, heterogeneous low-density tumor with cystic change in the left sublingual region. Magnetic resonance imaging showed a well-circumscribed, heterogeneous sublingual tumor with low-signal intensity on T1-weighted image and high-signal intensity in T2-weighted image. The lesion was diagnosed radiologically as benign sublingual gland tumor. The patient underwent resection of sublingual gland tumor under general anesthesia. There was no definitive continuity between the tumor and the sublingual gland, and the tumor originated from sublingual glandular branch of the lingual nerve. Pathological examination of the specimen showed schwannoma with highly cellular areas (Antoni A) and hypocellular areas (Antoni B). The postoperative course was uneventful without lingual nerve palsy, and there was no recurrence 4 years after surgery.

DOI： 10.1007/s11282-020-00447-w

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Anticancer Research USA Inc.  

DOI： 10.21873/cgp.20238

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: We compared outcomes and toxicities between concurrent retrograde super-selective intra-arterial chemoradiotherapy (IACRT) and concurrent systemic chemoradiotherapy (SCRT) for gingival carcinoma (GC). METHODS: We included 84 consecutive patients who were treated for non-metastatic GC ≥ stage III, from 2006 to 2018, in this retrospective analysis (IACRT group: n = 66; SCRT group: n = 18). RESULTS: The median follow-up time was 24 (range: 1-124) months. The median prescribed dose was 60 (6-70.2) Gy (IACRT: 60 Gy; SCRT: 69 Gy). There were significant differences between the two groups in terms of 3-year overall survival (OS; IACRT: 78.8, 95% confidence interval [CI]: 66.0-87.6; SCRT: 50.4, 95% CI: 27.6-73.0; P = 0.039), progression-free survival (PFS; IACRT: 75.6, 95% CI: 62.7-85.2; SCRT: 42.0, 95% CI: 17.7-70.9; P = 0.028) and local control rates (LC; IACRT: 77.2, 95% CI: 64.2-86.4; SCRT: 42.0, 95% CI: 17.7-70.9; P = 0.015). In univariate analysis, age ≥ 65 years, decreased performance status (PS) and SCRT were significantly associated with worse outcomes (P < 0.05). In multivariate analysis, age ≥ 65 years, clinical stage IV, and SCRT were significantly correlated with a poor OS rate (P < 0.05). Patients with poorer PS had a significantly worse PFS rate. Regarding acute toxicity, 22 IACRT patients had grade 4 lymphopenia, and osteoradionecrosis was the most common late toxicity in both groups. CONCLUSIONS: This is the first report to compare outcomes from IACRT and SCRT among patients with GC. ALL therapy related toxicities were manageable. IACRT is an effective and safe treatment for GC.

DOI： 10.1186/s12885-020-07638-y

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Ultraviolet treatment of titanium implants makes their surfaces hydrophilic and enhances osseointegration. However, the mechanism is not fully understood. This study hypothesizes that the recruitment of fibrinogen, a critical molecule for blood clot formation and wound healing, is influenced by the degrees of hydrophilicity/hydrophobicity of the implant surfaces. Computational fluid dynamics (CFD) implant models were created for fluid flow simulation. The hydrophilicity level was expressed by the contact angle between the implant surface and blood plasma, ranging from 5° (superhydrophilic), 30° (hydrophilic) to 50° and 70° (hydrophobic), and 100° (hydrorepellent). The mass of fibrinogen flowing into the implant interfacial zone (fibrinogen infiltration) increased in a time dependent manner, with a steeper slope for surfaces with greater hydrophilicity. The mass of blood plasma absorbed into the interfacial zone (blood plasma infiltration) was also promoted by the hydrophilic surfaces but it was rapid and non-time-dependent. There was no linear correlation between the fibrinogen infiltration rate and the blood plasma infiltration rate. These results suggest that hydrophilic implant surfaces promote both fibrinogen and blood plasma infiltration to their interface. However, the infiltration of the two components were not proportional, implying a selectively enhanced recruitment of fibrinogen by hydrophilic implant surfaces.

DOI： 10.3390/ijms21020660

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1177/0145561320961273

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.ajoms.2019.06.007

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記述言語：日本語   出版者・発行元：(一社)日本ハイパーサーミア学会  

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記述言語：日本語   出版者・発行元：(一社)日本ハイパーサーミア学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: The aim of this study was to evaluate the prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma (SCC) treated with intra-arterial infusion chemotherapy concurrent with radiotherapy. METHODS: A total of 46 patients were reviewed retrospectively in this study. The treatment schedule comprised intra-arterial chemotherapy (total, 60 mg/m2 docetaxel and 150 mg/m2 cisplatin) and three-dimensional computed tomography based, daily conventional radiotherapy (total, 60 Gy/30 fr) for 6 weeks. RESULTS: The median follow-up period was 40 months (range, 3-110 months). The 3-year overall survival and locoregional control rates for all patients were 64.3% and 84.3%, respectively. The OS rate of the patients with N0-1 was significantly higher than that of the patients with N ≥ 2 (P < .05). No grade 5 toxicities were observed. CONCLUSIONS: Intra-arterial infusion chemotherapy concurrent with radiotherapy was effective for advanced maxillary gingival SCC.

DOI： 10.1002/hed.25607

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

AIM: We aimed to retrospectively investigate the outcomes and pathological effects of retrograde superselective intra-arterial chemoradiotherapy (IACRT) combined with hyperthermia on metastatic lymph nodes of patients with oral squamous cell carcinoma. PATIENTS AND METHODS: Patients with lymph node metastasis from oral cancer were treated with IACRT using cisplatin plus docetaxel combined with hyperthermia prior to surgical removal 8 weeks after completion of IACRT and hyperthermia. The locoregional control and overall survival rates were calculated using the Kaplan-Meier method. RESULTS: A total of 35 patients received the combination therapy of whom 26 received it as definitive treatment and in the rest, it was administered as preoperative treatment. The 5-year locoregional control and overall survivaI rates were 95.6% and 80.2% in the definitive-treatment group, and 100% and 66.6% in the preoperative-treatment group, respectively. CONCLUSION: The combination therapy provided good outcomes in patients with lymph node metastases from advanced oral cancer.

DOI： 10.21873/anticanres.13250

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.7860/JCDR/2019/40036.12505

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

We herein report a case of squamous cell carcinoma of the buccal mucosa with N3 cervical lymph node metastasis in a 63-year-old man. The patient was treated with combination therapy comprising radiotherapy (2 Gy/day, total of 70 Gy), superselective intra-arterial chemotherapy via a superficial temporal artery (docetaxel, total of 70 mg/m2 and cisplatin, total of 175 mg/m2), cetuximab (initial dose of 400 mg/m2 with subsequent weekly doses of 250 mg/m2 intravenously), and four sessions of hyperthermia for cervical lymph node metastases. The patient responded well to the therapy, with a complete response of the primary tumor. Radical neck dissection was performed with reconstructive surgery, including resection of the overlying skin. A pathologic complete response was achieved for the N3 and all other cervical lymph node metastases. The patient showed no evidence of recurrence in the 3 years following treatment. Based on the findings in the present case, the use of retrograde superselective intra-arterial chemoradiotherapy combined with hyperthermia and cetuximab seems to be a promising modality for patients with N3 cervical lymph node metastasis of oral cancer.

DOI： 10.1007/s11282-018-0319-y

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Japan Society for Oral Tumors  

DOI： 10.5843/jsot.31.97

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background and objectives: The aim of present study was to compare the treatment results of daily cisplatin (CDDP), weekly docetaxel (DOC) intra-arterial infusion chemotherapy combined with radiotherapy (DIACRT) regimen and weekly CDDP intra-arterial infusion chemotherapy combined with radiotherapy (WIACRT) for patients with tongue cancer. Materials and Methods: Between January 2007 and December 2016, a total of 11 patients treated with WIACRT and 45 patients treated with DIACRT were enrolled in the present study. In the DIACRT group, 25 patients had late T2, and 20 patients had T3. A total of nine patients had late T2 and two had T3 in WIACRT (p = NS). In DIACRT, the treatment schedule consisted of intra-arterial chemotherapy (DOC, total 60 mg/m²; CDDP, total 150 mg/m²) and daily concurrent radiotherapy (RT) (total, 60 Gy). In WIACRT, the treatment schedule consisted of intra-arterial chemotherapy (CDDP, total 360 mg/m²) and daily concurrent RT (total, 60 Gy). Results: The median follow-up periods for DIACRT and WIACRT were 61 and 66 months, respectively. The five-year local control (LC) and overall survival (OS) rate were 94.5% and 89.6% for the DIACRT group, and 60.6% and 63.6% for the WIACRT group, respectively. The LC rate and OS of the DIACRT group were significantly higher than those of the WIACRT group. As regards toxicities, no treatment-related deaths were observed during the follow-up periods in both groups. Conclusions: DIACRT was found to be feasible and effective for patients with tongue cancer and could become a new treatment modality.

DOI： 10.3390/medicina54040052

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVES: To evaluate the therapeutic results and rate of organ preservation in patients with squamous cell carcinoma of the tongue treated with retrograde superselective intra-arterial chemoradiotherapy. MATERIALS AND METHODS: Between June 2006 and June 2015, 118 patients with tongue cancer were treated with intra-arterial chemoradiotherapy. Treatment consisted of radiotherapy (total 50-70 Gy) and daily concurrent intra-arterial chemotherapy (docetaxel, total 50-70 mg/m2; cisplatin, total 125-175 mg/m2) for 5-7 weeks. Locoregional control and overall survival rates were calculated by the Kaplan-Meier method. Cox's proportional hazards model was used for both univariate and multivariate analyses. RESULTS: The median follow-up for all patients was 38.5 months (range, 3-129 months). After intra-arterial chemoradiotherapy, primary site complete response was achieved in 113 (95.8%) of 118 cases. Three-year locoregional control and overall survival rates were 80.3% and 81.5%, respectively. Grade 3 or 4 toxicities included neutropenia in 16.1% and mucositis in 87.3%. Grade 3 toxicities included anemia in 12.7%, thrombocytopenia in 3.4%, nausea/vomiting in 3.4%, dermatitis in 45.7%, dysphagia in 74.6%, and fever in 2.5% of patients. Late toxicity consisting of grade 3 osteoradionecrosis of the jaw occurred in 4.2% of patients. On univariate analysis, T stage and overall stage were significantly associated with locoregional control, and N stage and overall stage were significantly associated with overall survival. On multivariate analysis, the only significant predictor of overall survival was overall stage classification. CONCLUSION: Retrograde superselective intra-arterial chemoradiotherapy for tongue cancer provided good overall survival and locoregional control.

DOI： 10.1016/j.oraloncology.2018.02.002

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.anl.2017.03.010

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記述言語：英語  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/ajco.12502

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier Ltd  

DOI： 10.1016/j.ajoms.2017.05.003

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s11282-016-0255-7

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記述言語：日本語   出版者・発行元：(一社)日本ハイパーサーミア学会  

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13014-017-0847-3

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.oooo.2017.02.004

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：日本語   出版者・発行元：(一社)日本頭頸部癌学会  

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記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.cllc.2015.11.013

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/hed.24421

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer India  

DOI： 10.1007/s12070-016-1008-y

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s13014-016-0637-3

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s00432-015-2069-0

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記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1093/jjco/hyv160

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1515/raon-2015-0034

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3747/co.22.2523

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記述言語：日本語   掲載種別：速報，短報，研究ノート等（学術雑誌）   出版者・発行元：(一社)日本口腔腫瘍学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔腫瘍学会  

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記述言語：日本語   出版者・発行元：(公社)日本口腔外科学会  

症例は56歳男性で、右側耳下腺部の腫脹を認め、CTで耳下腺唾石症と診断した。CTでは、右側耳下腺腺体内に3.6×2.5×1.7mm大の唾石を認めた。唾液腺内視鏡で診断的内視鏡検査を行い、耳下腺腺体内の導管の奥に唾石を認めた。唾石の破砕が必要で手術時間が長くなるため、全身麻酔下に内視鏡下唾石摘出術を施行した。手術翌日に退院した。その後の唾液の流出は良好で、術後1年9ヵ月以上経過した現在、耳下腺の腫脹や唾石の再発は認めていない。

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

症例は50歳代男性で、右側顎下部の腫脹が食事時に生じたため、近耳鼻咽喉科を受診した。右側顎下腺唾石症と診断され、顎下腺摘出術が必要と説明されたため、唾液腺内視鏡での低侵襲な治療を希望して当科受診となった。唾石は顎下腺腺体上部に存在していたため、内視鏡下での唾石摘出が困難であった場合には、内視鏡をガイドにした口内法で唾石の摘出を行い、それが困難であった場合には顎下腺摘出術が必要になることを患者に説明し、同意を得たうえで全身麻酔での手術を計画した。細い唾液腺内視鏡は腺体内まで挿入可能であり、主導管から2分岐目に唾石を確認できた。唾液腺内視鏡のワーキングチャンネルからバスケット鉗子を挿入し唾石を把持した。唾石が類円形であったこともあり、開口部を切開せずに摘出可能であった。術後2年3ヵ月経過するも顎下腺の腫脹や唾仙痛は認めず、経過良好である。

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

症例は70歳代男性で、右側口底部の腫瘤を自覚したが放置していた。その後に腫瘤の増大を認めたため近医歯科を受診した。口底腫瘍と診断され、某総合病院歯科口腔外科を紹介され生検が行われた。扁平上皮癌と診断されたため、加療目的に当科を紹介受診となった。画像所見より正中よりやや右側の口底癌の左側耳下腺リンパ節への転移が疑われたが、腫瘍がT1であり、健側の表在リンパ節であることより、リンパ節内に生じたWarthin腫瘍の可能性も考えられた。そのため、センチネルリンパ節生検を行った。病理組織学的所見では、耳下腺リンパ節は円柱状細胞と立方状細胞の二層性配列を示す上皮が管状、嚢胞状に増生し、間質には濾胞形成を伴うリンパ球浸潤を認め、Warthin腫瘍と診断した。センチネルリンパ節に転移を認めなかったため、経過観察を行い、術後11ヵ月経過するが無病生存中である。

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その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J02383&link_issn=&doc_id=20181105220004&doc_link_id=10.15214%2Fjsodom.31.211&url=https%3A%2F%2Fdoi.org%2F10.15214%2Fjsodom.31.211&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

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記述言語：日本語   出版者・発行元：(一社)日本ハイパーサーミア学会  

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

70歳代女。右側顎下部の腫脹を主訴とした。CTで右側顎下腺の腺体中央部に3.1×2.8×2.6mmの唾石を認め、右側顎下腺腺体内唾石症と診断した。唾石は腺体中央部に存在していたが、大きさが約3mm程度であり、CT値が低いため粉砕が容易にできる可能性が高く、更に顎下腺移行部から唾石まで唾液の貯留が描出されていたことから、内視鏡手術が可能と判断した。受診当日に外来局所麻酔下に内視鏡下唾石摘出術を施行し、手術時間は35分と短く、術後経過は良好であった。術後1年4ヵ月の現在、再発は認めていない。

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

15歳男。顔面非対称を主訴とした。7歳時より左耳翼基部の膨隆を自覚し、2年前に生検にて線維性異形成症(FD)と診断されていた。口腔外所見では左鼻翼から鼻根部や頬部にかけて膨隆し、斜鼻を認めた。口腔内所見では左側上顎歯肉唇移行部から口唇粘膜にかけて骨の膨隆を認めた。CTでは左上顎洞を後方に圧排するように境界明瞭な充実性病変を認め、左鼻腔は閉塞していた。3D-CTでは左鼻骨、左上顎骨、左頬骨の膨隆を認めた。FDとしては典型的な画像所見ではなかったため生検を行ったところ、病理組織学的に骨形成線維腫(OF)またはFDの所見であった。画像所見と併せて考えOFと診断し、ナビゲーション手術を計画した。腫瘍を摘出した後、術前に行った健側をミラーリングした画像まで骨の削除を行い、手術を終了した。術直後の3D-CTでは左側上顎の膨隆していた骨が計画通りに削除されていることが確認できた。病理診断はOFであった。術後2年6ヵ月の現在、知覚異常はなく、左右対称の顔貌と左鼻腔の開存が得られている。

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

症例は10歳男児で、食事時の右側顎下部の腫脹を認めた。CTにて右側顎下腺唾石症と診断した。右側口底後方粘膜に自壊部を認めたが、排膿は認めなかった。嘔吐反射が強く口底部の触診は困難であった。右側舌下小丘部からの唾液の流出は認めなかった。CTでは右側顎下腺移行部に56×56×42mmの硬組織像を認めた。臨床所見から、急性化膿性顎下腺炎により口底粘膜から排膿ととともに唾石が排出された後に、自壊部から顎下腺移行部に生じた肉芽組織が導管を閉塞させていると考え、閉塞性顎下腺炎と診断した。抗菌薬による消炎を行い、唾液腺内視鏡による閉塞物の摘出術を計画した。全身麻酔下で内視鏡手術を行った。外来経過観察時の唾液の流出は良好となり、以後、顎下腺の腫脹は生じていない。

DOI： 10.15214/jsodom.31.21

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記述言語：日本語  

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記述言語：日本語  

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記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

DOI： 10.5843/jsot.29.172

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

60代男性。左側耳下腺導管内唾石症と診断され、内視鏡下唾石摘出術を行う予定であった。しかし、初診から3週間後、左側頬部の腫脹や硬結の増大を認め、その中央部は自潰していた。自潰部からは排膿を認めたため、抗菌薬による消炎処置を継続したところ、1週間後に唾石と思われる石灰化物2個が自潰部から自然排出した。エコーでも唾石の残存がなく、1ヵ月経過後には左側頬部の腫脹は消失し、自潰部は完全に閉鎖していた。本例は、唾石に感染を併発したことで膿瘍が形成され、導管外の膿瘍腔へ唾石が逸脱し、皮膚瘻孔からの排膿とともに唾石が自然排出されたと考えられた。

DOI： 10.15214/jsodom.30.193

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

7歳男児。左顎下部の腫脹を主訴に前医を受診し、両側顎下腺導管移行部唾石と診断された。唾石のサイズが小さいことから、自然排出を期待して経過観察された。10ヵ月後に前医を再診し、唾石の位置と大きさに変化がみられなかったため顎下腺摘出術を提案されたが、本人と家族は内視鏡による低侵襲な治療を希望し、当科に紹介された。左側の唾石は1.7×1.7×1.1mm大で、初診2ヵ月後に開口部付近まで移動し、外来局所麻酔下に容易に摘出することができた。右側は3.0×1.6×1.5mm大で、初診8ヵ月後に開口部付近まで移動し、外来で容易に摘出することができた。

DOI： 10.15214/jsodom.30.223

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記述言語：日本語   出版者・発行元：(一社)日本口腔診断学会  

40歳代女性。左側頬部の腫脹と唾仙痛を主訴に近医耳鼻咽喉科を受診し、CTにて左側耳下腺腺体内唾石と診断され、手術目的に紹介となった。受診時、CTで唾石は1.7×1.4×1.0mmと比較的小さかったため、局所麻酔下に内視鏡下唾石摘出術を行った。術後経過は良好で、現在まで耳下腺の腫脹や唾石の再発は認められていない。

DOI： 10.15214/jsodom.30.52

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記述言語：日本語   出版者・発行元：(一社)日本口腔腫瘍学会  

DOI： 10.5843/jsot.28.65

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記述言語：英語   会議種別：ポスター発表  

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記述言語：英語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：英語   会議種別：口頭発表（一般）  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：英語   会議種別：ポスター発表  

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記述言語：英語   会議種別：ポスター発表  

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記述言語：日本語   会議種別：口頭発表（一般）  

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記述言語：日本語  

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記述言語：日本語  

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