記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER  

Objectives The aim of this study was to clarify the relationship between tumor hypoxia and microscopic diffusion capacity in primary brain tumors using Cu-62-Diacetyl-Bis (N4-Methylthiosemicarbazone) (Cu-62-ATSM) PET/CT and diffusion-weighted MR imaging (DWI).
Methods This study was approved by the institutional human research committee and was HIPAA compliant, and informed consent was obtained from all patients. Cu-62-ATSM PET/CT and DWI were performed in a total of 40 primary brain tumors of 34 patients with low grade glioma (LGG, n = 13), glioblastoma (GBM, n = 20), and primary central nervous system lymphoma (PCNSL, n = 7). Cu-62-ATSM PET/CT parameters and apparent diffusion coefficient (ADC) obtained by DWI were compared.
Results High intensity signals by Cu-62-ATSM PET/CT and DWI in patients with GBM and PCNSL, and low intensity signals in LGG patients were observed. An inverse correlation was found between maximum SUV (SUVmax) and minimum ADC (ADC(min)) (r = -0.583, p < 0.0001), and between tumor/brain ratio (T/B-ratio) and ADC(min) for all tumors (r = -0.532, p < 0.0001). Both SUVmax and T/B-ratio in GBM were higher than LGG (p < 0.0001 and p < 0.0001), and those in PCNSL were also higher than GBM (p = 0.033 and p = 0.044). The ADC(min) was lower in GBM (p = 0.011) and PCNSL (p = 0.01) than in LGG, while no significant difference was found between GBM and PCNSL (p = 0.90).
Conclusion Tumor hypoxia assessed by Cu-62-ATSM PET/CT correlated with microscopic diffusion capacity obtained by DWI in brain tumors. Both Cu-62-ATSM PET/CT and DWI were considered feasible imaging methods for grading glioma. However, Cu-62-ATSM PET/CT provided additional diagnostic information to differentiate between GBM and PCNSL.

DOI： 10.1007/s00259-014-2714-x

Web of Science

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Purpose: Bone elimination is needed for computed tomography angiography (CTA) because bone structures obscure aneurysms located at the skull base. The purpose of our study was to evaluate the efficacy of three-dimensional (3D)-CTA using an application for bone elimination. Materials and methods: A total of 27 patients with 32 angiographically confirmed aneurysms near the skull base were investigated. The 3D maximum intensity projection (MIP) images were initially obtained using the application. Further postprocessing was performed to obtain the MIP and volume-rendered (VR) images. The quality of the initial MIP images by the application was analyzed. Visualization of aneurysms after further processing was also reviewed. Results: The initial MIP images by the application showed almost bone-free images in 23 of the 27 patients. In 8 patients, the image of the internal carotid artery (ICA) was segmentally removed in the initial MIP images by the application. Further postprocessing was able to recover all loss of the ICA image in these eight patients. For visualizing aneurysms and their necks, VR images with the application were significantly superior to VR images without the application. Conclusion: The application for bone elimination allows fast, selective elimination of bony structures and can improve the interpretation of aneurysms near the skull base. © 2009 Japan Radiological Society.

DOI： 10.1007/s11604-008-0295-y

Scopus

PubMed

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記述言語：日本語   出版者・発行元：社団法人日本泌尿器科学会  

DOI： 10.5980/jpnjurol.99.509_1

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記述言語：日本語   出版者・発行元：金原出版  

CiNii Books

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記述言語：日本語   出版者・発行元：金原出版  

CiNii Books

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