2025/08/31 更新

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写真a

ナカジマ　ワキ
中島 和希
Waki Nakajima
所属
医学研究科 医科学専攻 生理学 講師
医学部 医学科
職名
講師
ホームページ
http://neurosci.med.yokohama-cu.ac.jp/
プロフィール

障害を持った方がリハビリテーションによってどのように回復・代償されるのか、その基本原理を解明することを目指しています。

特に、シナプス後膜上のAMPA受容体の分布と機能に着目し、行動学的・遺伝学的・免疫組織化学的・電気生理学的手法などといった多角的アプローチで、神経回路の可塑的変化メカニズムを探求しています。

近年は、AMPA受容体を標識するPETトレーサーや機能促進薬によるAMPA受容体の可視化・制御技術の開発に関わり、動物モデルからヒト臨床へのトランスレーショナル研究を推進中です。

外部リンク

学位

  • 博士（医学） （ 横浜市立大学 ）

研究分野

  • ライフサイエンス / 生理学

  • ライフサイエンス / リハビリテーション科学

学歴

  • 横浜市立大学

    2010年4月 - 2014年3月

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  • 北里大学大学院医学研究科医科学専攻 修士課程

    2008年4月 - 2010年3月

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  • 北里大学

    2004年4月 - 2008年3月

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経歴

  • 横浜市立大学医学部生理学 講師

    2023年4月 - 現在

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  • 横浜市立大学

    2019年4月 - 2023年3月

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  • 横浜市立大学   特任助教

    2016年6月 - 2019年3月

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  • 横浜市立大学   特任助手

    2014年4月 - 2016年5月

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所属学協会

  • 脳機能とリハビリテーション研究会

    2024年11月 - 現在

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  • 日本生理学会

    2024年8月 - 現在

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  • 日本理学療法士学会

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  • 日本神経科学会

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  • 北米神経科学会

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  • Motor Control研究会

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▼全件表示

委員歴

  • 日本基礎理学療法学会 評議員  

    2024年4月 - 現在   

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  • 第29回日本基礎理学療法学会学術大会 準備委員（総務）  

    2023年10月 - 2025年1月   

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  • 日本理学療法士協会 理学療法ガイドライン・用語策定委員会（MCI班班員）  

    2019年3月 - 2020年12月   

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    団体区分：学協会

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論文

  • First-in-Human Study of 18F-Labeled PET Tracer for Glutamate AMPA Receptor [18F]K-40: A Derivative of [11C]K-2. 国際誌

    Sadamitsu Ichijo, Tetsu Arisawa, Mai Hatano, Waki Nakajima, Tomoyuki Miyazaki, Tsuyoshi Eiro, Yuuki Takada, Ryunosuke Iai, Akane Sano, Masaki Sonoda, Yutaro Takayama, Yuichi Kimura, Takuya Takahashi

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine   2025年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Although the alteration of glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) distribution is believed to underlie physiologic and pathologic neuronal function, there has been no modality to evaluate AMPARs in a living human. [11C]K-2, the PET tracer we previously developed, is the first and only technology, to the best of our knowledge, to visualize AMPAR densities in the living human brain. Despite its favorable kinetics as a PET tracer, the short half-life of 11C limits the potential of [11C]K-2. We recently developed an 18F-labeled PET tracer, [18F]K-40, which demonstrated AMPAR-specific binding properties and brain distribution similar to that of [11C]K-2 in preclinical studies. The purpose of this first-in-human study is to evaluate the properties of [18F]K-40 in humans and to compare the kinetics and PET images of [18F]K-40 with those of [11C]K-2. Methods: Five healthy volunteers were enrolled and underwent dynamic PET imaging using [18F]K-40 and [11C]K-2. The nondisplaceable binding potential (BPND) with white matter as the reference was calculated by Logan graphical analysis using tissue time-activity curves (TACs), and the total distribution volume of [18F]K-40 was calculated using plasma TACs. The intraindividual correlation between BPND values obtained for [18F]K-40 and [11C]K-2 was examined. To optimize the time window for PET scanning, BPND and SUV ratio were evaluated. Results: The tissue TACs of [18F]K-40 showed curves similar to those of [11C]K-2. Logan graphical analysis using plasma TACs revealed reversible binding of [18F]K-40. The BPND obtained with [18F]K-40 and [11C]K-2 significantly correlated in each corresponding region and showed very good correlation, which indicated that K-40, as observed with K-2, can provide PET images that reflect the amount of AMPARs. A good linear relationship was observed between BPND and the summation image of SUV ratios between 40 and 50 min after radiotracer injection. Conclusion: [18F]K-40, as with [11C]K-2, has favorable binding properties as an AMPAR PET tracer. Thus, [18F]K-40 could characterize AMPAR distribution in pathophysiologic conditions of the brain and facilitate the development of novel diagnostics of neuropsychiatric disorders.

    DOI： 10.2967/jnumed.124.269405

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  • Edonerpic maleate enhances functional recovery from spinal cord injury with cortical reorganization in non-human primates

    Koichi Uramaru, Hiroki Abe, Waki Nakajima, Wataru Ota, Michiaki Suzuki, Osamu Yokoyama, Tetsuya Yamamoto, Yukio Nishimura, Takuya Takahashi

    BRAIN COMMUNICATIONS   7 ( 2 )   2025年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/braincomms/fcaf036

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  • α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor density underlies intraregional and interregional functional centrality

    Taisuke Yatomi, Dardo Tomasi, Hideaki Tani, Shinichiro Nakajima, Sakiko Tsugawa, Nobuhiro Nagai, Teruki Koizumi, Waki Nakajima, Mai Hatano, Hiroyuki Uchida, Takuya Takahashi

    Frontiers in Neural Circuits   18   2024年11月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Frontiers Media SA  

    Local and global functional connectivity densities (lFCD and gFCD, respectively), derived from functional magnetic resonance imaging (fMRI) data, represent the degree of functional centrality within local and global brain networks. While these methods are well-established for mapping brain connectivity, the molecular and synaptic foundations of these connectivity patterns remain unclear. Glutamate, the principal excitatory neurotransmitter in the brain, plays a key role in these processes. Among its receptors, the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) is crucial for neurotransmission, particularly in cognitive functions such as learning and memory. This study aimed to examine the association of the AMPAR density and FCD metrics of intraregional and interregional functional centrality. Using [<sup>11</sup>C]K-2, a positron emission tomography (PET) tracer specific for AMPARs, we measured AMPAR density in the brains of 35 healthy participants. Our findings revealed a strong positive correlation between AMPAR density and both lFCD and gFCD-lFCD across the entire brain. This correlation was especially notable in key regions such as the anterior cingulate cortex, posterior cingulate cortex, pre-subgenual frontal cortex, Default Mode Network, and Visual Network. These results highlight that postsynaptic AMPARs significantly contribute to both local and global functional connectivity in the brain, particularly in network hub regions. This study provides valuable insights into the molecular and synaptic underpinnings of brain functional connectomes.

    DOI： 10.3389/fncir.2024.1497897

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  • Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography

    Mai Hatano, Waki Nakajima, Hideaki Tani, Hiroyuki Uchida, Tomoyuki Miyazaki, Tetsu Arisawa, Yuuki Takada, Sakiko Tsugawa, Akane Sano, Kotaro Nakano, Tsuyoshi Eiro, Hiroki Abe, Akira Suda, Takeshi Asami, Akitoyo Hishimoto, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Shunya Kurokawa, Yohei Ohtani, Kie Takahashi, Yuhei Kikuchi, Taisuke Yatomi, Shiori Honda, Masahiro Jinzaki, Yoji Hirano, Ryo Mitoma, Shunsuke Tamura, Shingo Baba, Osamu Togao, Hirotaka Kosaka, Hidehiko Okazawa, Yuichi Kimura, Masaru Mimura, Takuya Takahashi

    Molecular Psychiatry   2024年10月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

    Abstract

    Synaptic phenotypes in living patients with psychiatric disorders are poorly characterized. Excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) is a fundamental component for neurotransmission. We recently developed a positron emission tomography (PET) tracer for AMPAR, [<sup>11</sup>C]K-2, the first technology to visualize and quantify AMPARs density in living human brain. In this study, we characterized patients with major psychiatric disorders with [<sup>11</sup>C]K-2. One hundred forty-nine patients with psychiatric disorders (schizophrenia, n = 42; bipolar disorder, n = 37; depression, n = 35; and autism spectrum disorder, n = 35) and 70 healthy participants underwent a PET scan with [<sup>11</sup>C]K-2 for measurement of AMPAR density. We detected brain regions that showed correlation between AMPAR density and symptomatology scores in each of four disorders. We also found brain areas with significant differences in AMPAR density between patients with each psychiatric disorder and healthy participants. Some of these areas were observed across diseases, indicating that these are commonly affected areas throughout psychiatric disorders. Schizophrenia, bipolar disorder, depression, and autism spectrum disorder are uniquely characterized by AMPAR distribution patterns. Our approach to psychiatric disorders using [<sup>11</sup>C]K-2 can elucidate the biological mechanisms across diseases and pave the way to develop novel diagnostics and therapeutics based on the synapse physiology.

    DOI： 10.1038/s41380-024-02785-1

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    その他リンク： https://www.nature.com/articles/s41380-024-02785-1

  • Enhancement of angiotensin II type 1 receptor-associated protein in the paraventricular nucleus suppresses angiotensin II-dependent hypertension. 国際誌

    Mari Sotozawa, Sho Kinguchi, Hiromichi Wakui, Kengo Azushima, Kengo Funakoshi, Waki Nakajima, Tomoyuki Miyazaki, Takuya Takahashi, Kouichi Tamura

    Hypertension research : official journal of the Japanese Society of Hypertension   2023年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The renin-angiotensin system in the brain plays a pivotal role in modulating sympathetic nerve activity and contributes to the pathogenesis of hypertension. Angiotensin II (Ang II) type 1 receptor (AT1R)-associated protein (ATRAP) promotes internalization of AT1R while suppressing pathological overactivation of AT1R signaling. However, the pathophysiological function of ATRAP in the brain remains unknown. Therefore, this study aims to investigate whether ATRAP in the paraventricular nucleus (PVN) is involved in neurogenic hypertension pathogenesis in Ang II-infused rats. The ATRAP/AT1R ratio, which serves as an indicator of tissue AT1R hyperactivity, tended to decrease within the PVN in the Ang II group than in the vehicle group. This suggests an Ang II-induced hyperactivation of the AT1R signaling pathway in the PVN. Lentiviral vectors were generated to stimulate ATRAP expression. At 6 weeks of age, rats were microinjected with LV-Venus (Venus-expressing lentivirus) or LV-ATRAP (Venus-ATRAP-expressing lentivirus). The rats were then randomly divided into four groups: (1) Vehicle/LV-Venus, (2) Vehicle/LV-ATRAP, (3) Ang II/LV-Venus, and (4) Ang II/LV-ATRAP. Two weeks after microinjection, vehicle or Ang II was administered systemically for 2 weeks. In the Ang II/LV-ATRAP group, systolic blood pressure at 1 and 2 weeks following administration was significantly lower than that in the Ang II/LV-Venus group. Furthermore, urinary adrenaline levels tended to decrease in the Ang II/LV-ATRAP group than in the Ang II/LV-Venus group. These findings suggest that enhanced ATRAP expression in the PVN suppresses Ang II-induced hypertension, potentially by suppressing hyperactivation of the tissue AT1R signaling pathway and, subsequently, sympathetic nerve activity.

    DOI： 10.1038/s41440-023-01480-y

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  • てんかん病態を制御する脳内AMPA受容体の動態

    永露 毅, 宮崎 智之, 波多野 真依, 中島 和希, 有澤 哲, 高田 由貴, 木村 キミト, 野田 賀大, 内田 裕之, 木村 裕一, 高橋 琢哉

    核医学技術   43 ( 予稿集 )   321 - 321   2023年10月

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    記述言語：日本語   出版者・発行元：(NPO)日本核医学技術学会  

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  • IDH1変異グリオーママウスモデルにおける変異型IDH1阻害剤のてんかん抑制効果の検討

    林 貴啓, 立石 健祐, 池谷 直樹, 園田 真樹, 高山 裕太郎, 宮崎 智之, 中島 和希, 山本 哲哉

    てんかん研究   41 ( 2 )   440 - 440   2023年9月

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    記述言語：日本語   出版者・発行元：(一社)日本てんかん学会  

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  • Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy. 国際誌

    Tsuyoshi Eiro, Tomoyuki Miyazaki, Mai Hatano, Waki Nakajima, Tetsu Arisawa, Yuuki Takada, Kimito Kimura, Akane Sano, Kotaro Nakano, Takahiro Mihara, Yutaro Takayama, Naoki Ikegaya, Masaki Iwasaki, Akitoyo Hishimoto, Yoshihiro Noda, Takahiro Miyazaki, Hiroyuki Uchida, Hideaki Tani, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Masaru Mimura, Nozomu Matsuda, Kazuaki Kanai, Kazuhiro Takahashi, Hiroshi Ito, Yoji Hirano, Yuichi Kimura, Riki Matsumoto, Akio Ikeda, Takuya Takahashi

    Cell reports. Medicine   4 ( 5 )   101020 - 101020   2023年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) contribute to epileptogenesis. Thirty patients with epilepsy and 31 healthy controls are scanned using positron emission tomography with our recently developed radiotracer for AMPARs, [11C]K-2, which measures the density of cell-surface AMPARs. In patients with focal-onset seizures, an increase in AMPAR trafficking augments the amplitude of abnormal gamma activity detected by electroencephalography. In contrast, patients with generalized-onset seizures exhibit a decrease in AMPARs coupled with increased amplitude of abnormal gamma activity. Patients with epilepsy had reduced AMPAR levels compared with healthy controls, and AMPARs are reduced in larger areas of the cortex in patients with generalized-onset seizures compared with those with focal-onset seizures. Thus, epileptic brain function can be regulated by the enhanced trafficking of AMPAR due to Hebbian plasticity with increased simultaneous neuronal firing and compensational downregulation of cell-surface AMPARs by the synaptic scaling.

    DOI： 10.1016/j.xcrm.2023.101020

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  • Synthesis of [F-18] fluorine-labeled K-2 derivatives as radiotracers for AMPA receptors 査読

    Tetsu Arisawa, Kimito Kimura, Tomoyuki Miyazaki, Yuuki Takada, Waki Nakajima, Wataru Ota, Sadamitsu Ichijo, Akane Sano, Yuuka Hirao, Jun-ichi Kurita, Yoshifumi Nishimura, Takuya Takahashi

    NUCLEAR MEDICINE AND BIOLOGY   110   47 - 58   2022年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.nucmedbio.2022.04.009

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  • Epileptic discharges initiate from brain areas with elevated accumulation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors. 査読 国際誌

    Tomoyuki Miyazaki, Yutaro Takayama, Masaki Iwasaki, Mai Hatano, Waki Nakajima, Naoki Ikegaya, Tetsuya Yamamoto, Shohei Tsuchimoto, Hiroki Kato, Takuya Takahashi

    Brain communications   4 ( 2 )   fcac023   2022年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Presurgical identification of the epileptogenic zone is a critical determinant of seizure control following surgical resection in epilepsy. Excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor is a major component of neurotransmission. Although elevated α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor levels are observed in surgically resected brain areas of patients with epilepsy, it remains unclear whether increased α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor-mediated currents initiate epileptic discharges. We have recently developed the first PET tracer for α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, [11C]K-2, to visualize and quantify the density of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors in living human brains. Here, we detected elevated [11C]K-2 uptake in the epileptogenic temporal lobe of patients with mesial temporal lobe epilepsy. Brain areas with high [11C]K-2 uptake are closely colocalized with the location of equivalent current dipoles estimated by magnetoencephalography or with seizure onset zones detected by intracranial electroencephalogram. These results suggest that epileptic discharges initiate from brain areas with increased α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors, providing a biological basis for epileptic discharges and an additional non-invasive option to identify the epileptogenic zone in patients with mesial temporal lobe epilepsy.

    DOI： 10.1093/braincomms/fcac023

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  • Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects. 査読 国際誌

    Mai Hatano, Tomoyuki Miyazaki, Yoshinobu Ishiwata, Waki Nakajima, Tetsu Arisawa, Yoko Kuroki, Ayako Kobayashi, Yuuki Takada, Matsuyoshi Ogawa, Kazunori Kawamura, Ming-Rong Zhang, Makoto Higuchi, Masataka Taguri, Yasuyuki Kimura, Takuya Takahashi

    Scientific reports   11 ( 1 )   1598 - 1598   2021年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    [11C]K-2, a radiotracer exhibiting high affinity and selectivity for α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs), is suitable for the quantification of AMPARs in living human brains and potentially useful in the identification of epileptogenic foci in patients. This study aimed to estimate the radiation doses of [11C]K-2 in various organs and calculate the effective dose after injection of [11C]K-2 in healthy human subjects. Twelve healthy male subjects were registered and divided into two groups (370 or 555 MBq of [11C]K-2), followed by 2 h whole-body scans. We estimated the radiation dose of each organ and then calculated the effective dose for each subject. The highest uptake of [11C]K-2 was observed in the liver, while the brain also showed relatively high uptake. The urinary bladder exhibited the highest radiation dose. The kidneys and liver also showed high radiation doses after [11C]K-2 injections. The effective dose of [11C]K-2 ranged from 5.0 to 5.2 μSv/MBq. Our findings suggest that [11C]K-2 is safe in terms of the radiation dose and adverse effects. The injection of 370-555 MBq (10 to 15 mCi) for PET studies using this radiotracer is applicable in healthy human subjects and enables serial PET scans in a single subject.

    DOI： 10.1038/s41598-021-81002-3

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  • Visualization of AMPA receptors in living human brain with positron emission tomography. 査読 国際誌

    Tomoyuki Miyazaki, Waki Nakajima, Mai Hatano, Yusuke Shibata, Yoko Kuroki, Tetsu Arisawa, Asami Serizawa, Akane Sano, Sayaka Kogami, Tomomi Yamanoue, Kimito Kimura, Yushi Hirata, Yuuki Takada, Yoshinobu Ishiwata, Masaki Sonoda, Masaki Tokunaga, Chie Seki, Yuji Nagai, Takafumi Minamimoto, Kazunori Kawamura, Ming-Rong Zhang, Naoki Ikegaya, Masaki Iwasaki, Naoto Kunii, Yuichi Kimura, Fumio Yamashita, Masataka Taguri, Hideaki Tani, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Masaru Mimura, Michisuke Yuzaki, Hiroki Kato, Makoto Higuchi, Hiroyuki Uchida, Takuya Takahashi

    Nature medicine   26 ( 2 )   281 - 288   2020年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Although aberrations in the number and function of glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors are thought to underlie neuropsychiatric disorders, no methods are currently available for visualizing AMPA receptors in the living human brain. Here we developed a positron emission tomography (PET) tracer for AMPA receptors. A derivative of 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide radiolabeled with 11C ([11C]K-2) showed specific binding to AMPA receptors. Our clinical trial with healthy human participants confirmed reversible binding of [11C]K-2 in the brain according to Logan graphical analysis (UMIN000020975; study design: non-randomized, single arm; primary outcome: dynamics and distribution volumes of [11C]K-2 in the brain; secondary outcome: adverse events of [11C]K-2 during the 4-10 d following dosing; this trial met prespecified endpoints). In an exploratory clinical study including patients with epilepsy, we detected increased [11C]K-2 uptake in the epileptogenic focus of patients with mesial temporal lobe epilepsy, which was closely correlated with the local AMPA receptor protein distribution in surgical specimens from the same individuals (UMIN000025090; study design: non-randomized, single arm; primary outcome: correlation between [11C]K-2 uptake measured with PET before surgery and AMPA receptor protein density examined by biochemical study after surgery; secondary outcome: adverse events during the 7 d following PET scan; this trial met prespecified endpoints). Thus, [11C]K-2 is a potent PET tracer for AMPA receptors, potentially providing a tool to examine the involvement of AMPA receptors in neuropsychiatric disorders.

    DOI： 10.1038/s41591-019-0723-9

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  • CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage. 査読 国際誌

    Hiroki Abe, Susumu Jitsuki, Waki Nakajima, Yumi Murata, Aoi Jitsuki-Takahashi, Yuki Katsuno, Hirobumi Tada, Akane Sano, Kumiko Suyama, Nobuyuki Mochizuki, Takashi Komori, Hitoshi Masuyama, Tomohiro Okuda, Yoshio Goshima, Noriyuki Higo, Takuya Takahashi

    Science (New York, N.Y.)   360 ( 6384 )   50 - 57   2018年4月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：American Association for the Advancement of Science  

    DOI： 10.1126/science.aao2300

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  • Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex. 査読 国際誌

    Hirobumi Tada, Tomoyuki Miyazaki, Kiwamu Takemoto, Susumu Jitsuki, Waki Nakajima, Mayu Koide, Naoko Yamamoto, Akiko Taguchi, Honami Kawai, Kasane Komiya, Kumiko Suyama, Hiroki Abe, Akane Sano, Takuya Takahashi

    Scientific reports   7 ( 1 )   8471 - 8471   2017年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41598-017-08849-3

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  • Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex. 査読 国際誌

    Hirobumi Tada, Tomoyuki Miyazaki, Kiwamu Takemoto, Kenkichi Takase, Susumu Jitsuki, Waki Nakajima, Mayu Koide, Naoko Yamamoto, Kasane Komiya, Kumiko Suyama, Akane Sano, Akiko Taguchi, Takuya Takahashi

    Proceedings of the National Academy of Sciences of the United States of America   113 ( 45 )   E7097-E7105 - E7105   2016年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1073/pnas.1606351113

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  • Nogo Receptor Signaling Restricts Adult Neural Plasticity by Limiting Synaptic AMPA Receptor Delivery. 査読 国際誌

    Susumu Jitsuki, Waki Nakajima, Kiwamu Takemoto, Akane Sano, Hirobumi Tada, Aoi Takahashi-Jitsuki, Takuya Takahashi

    Cerebral cortex (New York, N.Y. : 1991)   26 ( 1 )   427 - 439   2016年1月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/cercor/bhv232

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  • Sustained Enhancement of Lateral Inhibitory Circuit Maintains Cross Modal Cortical Reorganization. 査読 国際誌

    Waki Nakajima, Susumu Jitsuki, Akane Sano, Takuya Takahashi

    PloS one   11 ( 2 )   e0149068   2016年

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1371/journal.pone.0149068

    Web of Science

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  • Disrupted cortical function underlies behavior dysfunction due to social isolation. 査読 国際誌

    Tomoyuki Miyazaki, Kenkichi Takase, Waki Nakajima, Hirobumi Tada, Daisuke Ohya, Akane Sano, Takahisa Goto, Hajime Hirase, Roberto Malinow, Takuya Takahashi

    The Journal of clinical investigation   122 ( 7 )   2690 - 701   2012年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1172/JCI63060

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MISC

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受賞

  • 一般演題優秀発表賞 (基礎研究部門)

    2024年11月   脳機能とリハビリテーション研究会 第30回記念学術集会  

    中島和希

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  • 若手奨励賞

    2016年9月   第10回モーターコントロール研究会  

    中島和希

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共同研究・競争的資金等の研究課題

  • AMPA受容体分布に基づいた脳損傷後の運動機能回復を担う神経回路の解明

    研究課題/領域番号：23K10432  2023年4月 - 2026年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    中島 和希

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    配分額：4680000円 （ 直接経費：3600000円 、 間接経費：1080000円 ）

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  • 脳卒中後リハビリテーションによる回復メカニズムの回復時期縦断的理解

    研究課題/領域番号：19K19913  2019年4月 - 2023年3月

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    中島 和希

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    配分額：4030000円 （ 直接経費：3100000円 、 間接経費：930000円 ）

    脳損傷後のリハビリテーション（リハビリ）が効果的な時期が存在すると考えられているが、慢性期においても一定のリハビリの効果は認められる。では、機能回復の幅が大きいとされる回復期と慢性期リハビリによる機能回復メカニズムは同一であろうか。本研究では、回復期と慢性期に着目して、それぞれの神経回路再構築メカニズムを明らかにする。回復期と慢性期で共通して観察される神経回路再構築と非共通な神経回路再構築をAMPA受容体に着目して明らかにし、脳損傷後の機能回復メカニズムを回復時期縦断的に明らかにすることを目的とする。
    これまでの成果として、内包出血モデルを作製し、AMPA受容体標識PET probeを用いたPET（AMPA受容体PET）撮像を進めてきた。2021年度の研究実績として、内包出血モデルラットを用いて、AMPA受容体高発現部位の検討を行った。少数での定性的な検討ではあるが、損傷3か月後から1か月間のリハビリ（5日/週）を行うと、損傷半球の運動関連領野、線条体にAMPA受容体高集積領域を認めた。興味深いことに、十分な機能回復を示さなかったラットについても、AMPA受容体高集積部位が認められた。現在、回復動物と非回復動物間における、AMPA受容体高発現部位の領域の違いや体積の違いについて検討を行っている。

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  • 損傷前のAMPA受容体シナプス移行能が脳損傷後の機能回復を促進するメカニズム

    研究課題/領域番号：17K13060  2017年4月 - 2019年3月

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    中島 和希

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    配分額：3900000円 （ 直接経費：3000000円 、 間接経費：900000円 ）

    豊かな環境下で飼育したマウスはリーチングタスクの学習効率が向上することが明らかになった。また、脳損傷後の機能回復において、損傷早期において、機能回復を促進する可能性が示唆された。本研究では、認められた現象のメカニズムには迫ることができなかったが、脳に損傷を受ける前に豊かな環境で生活することで、脳損傷後の回復が早く、社会的負担が軽減する可能性があると考えられる。

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担当経験のある科目（授業）

  • 生理学

    2023年4月 - 現在 機関名：横浜市立大学

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  • 体育 バドミントン

    2013年4月 - 2014年3月 機関名：東京電機大学

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