Updated on 2025/04/30

写真a

 
Sakura Eri Bautista Maezono
 
Organization
Advanced Medical Research Center Assistant Professor
Title
Assistant Professor
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Research Interests

  • Sleep Medicine

  • Machine Learning

  • Oncology

  • Neuroscience

  • Bioinformatics

  • Big data Analytics

  • Computational Genomics

  • Drug discovery

Research Areas

  • Informatics / Life, health and medical informatics  / Bioinformatics

  • Life Science / Neuroscience-general  / Sleep medicine

Education

  • University of Tsukuba   Graduate School of Integrative and Global Majors   Ph.D. in Human Biology

    2015.9 - 2020.8

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    Country: Japan

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  • University of Tsukuba   Faculty of Life and Environmental Sciences   Biology

    2012.9 - 2015.7

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    Country: Japan

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Research History

  • Advanced Medical Research Center, Yokohama City University   Bioinformatics Laboratory   Assistant Professor

    2023.4

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    Country:Japan

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  • The Janssen Pharmaceutical Companies of Johnson & Johnson   Medical Affairs   Intern

    2020.7 - 2020.8

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    Notes:Evidence generation for the possibility of drug repurposing under the Neuroscience team of the Medical Affairs department

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  • Craif Inc.   Analytics   Bioinformatics Researcher

    2020.6 - 2023.3

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  • Computational Biology and Integrative Genomics, University of Oxford   Oncology   Research Intern

    2018.4 - 2018.10

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    Country:United Kingdom

    Notes:In silico studies validating the performance of gene signatures in a pan-cancer study using RNA seq data from >10,000 human tissue samples under the supervision of Prof. Francesca Buffa; After the internship, the collaboration continued until I graduated

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Professional Memberships

  • The Molecular Biology Society of Japan

    2023.4

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Papers

  • Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity. International journal

    Samuel B Bader, Tiffany S Ma, Charlotte J Simpson, Jiachen Liang, Sakura Eri B Maezono, Monica M Olcina, Francesca M Buffa, Ester M Hammond

    Nucleic acids research   49 ( 13 )   7492 - 7506   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    Tumor heterogeneity includes variable and fluctuating oxygen concentrations, which result in the accumulation of hypoxic regions in most solid tumors. Tumor hypoxia leads to increased therapy resistance and has been linked to genomic instability. Here, we tested the hypothesis that exposure to levels of hypoxia that cause replication stress could increase APOBEC activity and the accumulation of APOBEC-mediated mutations. APOBEC-dependent mutational signatures have been well-characterized, although the physiological conditions which underpin them have not been described. We demonstrate that fluctuating/cyclic hypoxic conditions which lead to replication catastrophe induce the expression and activity of APOBEC3B. In contrast, stable/chronic hypoxic conditions which induce replication stress in the absence of DNA damage are not sufficient to induce APOBEC3B. Most importantly, the number of APOBEC-mediated mutations in patient tumors correlated with a hypoxia signature. Together, our data support the conclusion that hypoxia-induced replication catastrophe drives genomic instability in tumors, specifically through increasing the activity of APOBEC3B.

    DOI: 10.1093/nar/gkab551

    PubMed

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  • Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice

    Evgenii Zavjalov, Alexander Zaboronok, Vladimir Kanygin, Anna Kasatova, Aleksandr Kichigin, Rinat Mukhamadiyarov, Ivan Razumov, Tatiana Sycheva, Bryan J. Mathis, Sakura Eri B. Maezono, Akira Matsumura, Sergey Taskaev

    International Journal of Radiation Biology   1 - 11   2020.7

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    Publishing type:Research paper (scientific journal)   Publisher:Informa {UK} Limited  

    DOI: 10.1080/09553002.2020.1761039

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  • Progressive Changes in Sleep and Its Relations to Amyloid-β Distribution and Learning in SingleAppKnock-In Mice

    Sakura Eri B. Maezono, Mika Kanuka, Chika Tatsuzawa, Miho Morita, Taizo Kawano, Mitsuaki Kashiwagi, Pimpimon Nondhalee, Masanori Sakaguchi, Takashi Saito, Takaomi C. Saido, Yu Hayashi

    eneuro   2020.3

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/ENEURO.0093-20.2020

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  • Suppressive effect of Caffeic acid and Caffeic Acid Phenethyl Ester on Oxidative Stress in B16 Mouse Melanoma and Human Epidermal Melanocytes

    Maezono, Sakura Eri B, Villareal, Myra O, Junkyu,Han, Isoda, Hiroko

    ICP2014 Nagoya Polyphenols Communications   2014   119 - 119   2014.9

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    Authorship:Lead author  

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Presentations

  • Regulation of myelopoiesis by transcribed enhancers long-noncoding RNAs (e-lncRNAs)

    Jordan Ramilowski, Sakura Eri B. Maezono

    46th Molecular Biology Society Meeting  2023.12 

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    Event date: 2023.12

    Language:English   Presentation type:Poster presentation  

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  • Mabuhay World Citizens’ Retirement Homes: A hybrid of a research institute and a vacation home for retirees.

    Sakura Eri, B. Maezono, Arvin Valderrama

    Tsukuba Global Science Week 2016  2016.9 

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    Language:English   Presentation type:Oral presentation (general)  

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  • Cymbopogon schoenanthus ethanol extract has a melanogenesis-regulatory effect on human epidermal melanocytes

    Sakura Eri, B. Maezono, Myra O. Villareal, Junkyu Han, Hiroko Isoda

    Tsukuba Global Science Week  2013.10 

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    Language:English   Presentation type:Poster presentation  

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  • Inhibitory Effect of Caffeic acid and Caffeic Acid Phenethyl Ester on Oxidative Stress in Human Epidermal Melanocytes

    Sakura Eri, B. Maezono, Myra O. Villareal, Junkyu Han, Hiroko Isoda

    12th Tunisia-Japan Symposium on Science, Society and Technology 2013  2013.11 

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    Language:English   Presentation type:Poster presentation  

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  • Characterization of Sleep architecture and Cognitive ability of the APP- NL-G-F mice

    Sakura Eri, B. Maezono, Mika Kanuka, Miho Morita, Pimpimon Nondhalee, Masanori Sakaguchi, Takashi Saito, Takaomi Saido, Yu Hayashi

    Tsukuba Global Science Week 2017  2017.9 

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    Language:English   Presentation type:Oral presentation (general)  

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  • Abnormal Sleep and Cognitive ability in an App Knock-in Mouse Model of Alzheimer’s Disease

    Sakura Eri, B. Maezono, Mika Kanuka, Chika Tatsuzawa, Miho Morita, Mitsuaki Kashiwagi, Pimpimon Nondhalee, Masanori Sakaguchi, Takashi Saito, Takaomi Saido, Yu Hayashi

    Tsukuba Conference 2019  2019.10 

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    Language:English   Presentation type:Oral presentation (general)  

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  • Overcoming Challenges of Work-life balance Invited

    Sakura Eri B. Maezono

    University of Tsukuba Leading Graduate Program Alumni Conference: Driving the Change for 10 years  2022.3 

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    Language:English   Presentation type:Oral presentation (invited, special)  

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  • 尿中エクソソーム内包マイクロ RNA を用いた乳癌スクリーニング検査の開発

    金光 秀一, 加藤 容崇, 高山 和也, Maezono Sakura Eri, 有井 栞, 西山 結美, 市川 裕樹, 三角 知子, 太良 哲彦, 相良 安昭

    第32回日本乳癌検診学会学術総会  2022.11 

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    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 尿検体の保管・配送温度に対する尿中miRNAプロファイルの安定性

    山口裕樹, Maezono, Sakura Eri B, 高山和也, 西山結美, 市川裕樹

    第7回 Liquid Biopsy研究会  2023.1 

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    Language:Japanese   Presentation type:Poster presentation  

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  • In vitro Suppressive Effect of Caffeic acid and Its Derivative, Caffeic Acid Phenethyl Ester on Oxidative Stress

    Sakura Eri, B. Maezono, Myra O. Villareal, Junkyu Han, Hiroko Isoda

    XXVIIth International Conference on Polyphenols 2014  2014.9 

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    Language:English   Presentation type:Oral presentation (general)  

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  • Genome-wide identification and functional characterization of lncRNAs in dendritic cell differentiation

    Sakura Maezono, Akira Nishiyama, Takaya Yamasaki, Tomohiko Tamura, Jordan Ramilowski, In collaboration with, Ramzan Umarov, Chung-Chau Hon, Daisuke Kurotaki

    1st Asia & Pacific Bioinformatics Joint Conference  2024.10 

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    Language:English   Presentation type:Poster presentation  

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Awards

  • Best Pitch and Technology Project Award

    2019.12   Appropriate Technology, University of Tsukuba  

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  • Outstanding poster award

    2019.10   Tsukuba Conference 2019   Abnormal Sleep and Cognitive ability in an App Knock-in Mouse Model of Alzheimer’s Disease

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  • Best poster award and start-up grant

    2018.3   7th Hyper Interdisciplinary Conference   Best poster award and start-up grant

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  • Future International Leader Award and Student Award

    2017.10   Program for Leading Graduate Schools Forum 2017  

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  • Best Discussant

    2016.1   5th RIKEN BRC-Nanjing University MARC Mouse Resource Workshop  

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  • Special Fellow

    2015.8   University of Tsukuba  

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Other

  • LinkedIn Profile

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    https://www.linkedin.com/in/sakura-eri-maezono-ph-d-1729b8b6/

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Teaching Experience

  • Special Practical Bioinformatics Course: Single-Cell & Tissue Insights​ from Public Cancer RNA-seq Data

    2024.1 - 2024.3 Institution:Yokohama City University

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  • Current Trends in Bioinformatics

    2023.11 Institution:Yokohama City University

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  • Practical Bioinformatics

    2023.5 - 2023.10 Institution:Yokohama City University

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  • Prominent Discoveries in Neuroscience

    2019.4 - 2020.5 Institution:International Institute for Integrative Sleep Medicine, University of Tsukuba

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