Updated on 2025/07/04

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写真a

 
Shintaro Minegishi
 
Organization
Yokohama City University Hospital Emergency Care Department Assistant Professor
Title
Assistant Professor
Profile

2007年横浜市立大学医学部旧第二内科(循環器・腎臓・高血圧内科)に入局。循環器診療と同時に基礎および臨床研究に従事し、主に食塩感受性高血圧症におけるユビキチン化酵素Nedd4-2の分子病態生理研究に携わってきた。2013年博士号取得。2016年日本高血圧学会総会Young Investigator Award(YIA)最優秀賞受賞。2017年横浜市立大学医学部第二内科同門会賞優秀賞受賞。「食塩感受性高血圧症の病態解明」を発展させるため、2018年から2022年までDuke-NUS(Titze研究室)に留学(日本心臓財団バイエル薬品海外留学助成、公益信託循環器学研究振興基金)。2020年には香川大学薬理学教室で協力研究員(日本学術振興会二国間交流事業一員)。2021年日本高血圧学会総会(高血圧関連疾患モデル学会合同企画)Splendid basic Hypertension Research(SHR)賞最優秀賞受賞。帰国後も、カリウム喪失と体液保持機構に着目した本態性高血圧成因・アルドステロン/MR系に関わる基礎および臨床研究を継続し、日本高血圧学会 フューチャープラン委員会・ワーキンググループメンバーとして"Onco-Hypertension"という新たな診療・学術領域を展開している。2024年4月より横浜市立大学附属病院にて腫瘍循環器外来開設。日本高血圧学会 基礎研究推進部会メンバー。

【職歴】

2005年 海老名総合病院 初期臨床研修医
2007年 国際医療福祉大学熱海病院 循環器内科 医員
2009年 横浜市立大学大学院 医学研究科病態制御内科学
2013年 大森赤十字病院 循環器内科 医員
2015年 横浜市立大学附属病院 救急部(循環器内科) 助教
2017年 神奈川県立循環器呼吸器病センター 循環器内科 医長
2018年 Duke-NUS Medical School Cardiovascular & Metabolic Disorders Visiting Research Fellow
2019年 Duke-NUS Medical School Cardiovascular & Metabolic Disorders Research Fellow
2020年 香川大学薬理学 協力研究員
2022年 Duke-NUS Medical School Cardiovascular & Metabolic Disorders Senior Research Fellow
2022年 横浜市立大学附属病院 救急科(循環器内科) 助教
2023年 横浜市立大学附属病院 CCU(循環器内科) 助教
2024年 横浜市立大学附属病院 救急科(循環器内科) 診療講師

【資格】

日本循環器学会認定循環器専門医、日本内科学会認定内科認定医・総合内科専門医・指導医、日本プライマリ・ケア連合学会認定医・指導医、JMECC受講修了、日本医師会認定産業医、身体障害者福祉法第15条指定医(心臓機能障害)、難病医療費助成指定医、厚生労働省医政局長認定臨床研修指導医、共用試験医学系OSCE評価者認定講習会修了、医学博士

External link

Degree

  • Doctor of Philosophy ( 2013.3   Yokohama City University Graduate School of Medicine )

Research Interests

  • Onco-Hypertension

  • Onco-Cardiology

  • Cardiology

  • Cardiovascular-Kidney-Metabolic Syndrome

  • Water Conservation System

  • Translational Research

  • Aldosterone

  • Metabolism

  • Salt Sensitivity

Research Areas

  • Life Science / Metabolism and endocrinology

  • Life Science / Cardiology

  • Life Science / Nephrology

Education

  • Yokohama City University   Graduate   Graduate School of Medicine

    2009.4 - 2013.3

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Research History

  • Yokohama City University   Hospital Emergency Care Department (Cardiology)   Assistant Professor   Clinical Lecturer

    2024.4

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  • Yokohama City University   Hospital CCU   Assistant Professor

    2023.4 - 2024.3

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  • Yokohama City University   Hospital Emergency Care Department   Assistant Professor

    2022.4 - 2023.3

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  • Duke-NUS Medical School   Cardiovascular & Metabolic Disorders   Senior Research Fellow

    2022.1 - 2022.3

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    Country:Singapore

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  • Kagawa University   School of Medicine Pharmacology

    2020.6 - 2020.7

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    Country:Japan

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  • Duke-NUS Medical School   Cardiovascular & Metabolic Disorders   Research Fellow

    2019.3 - 2021.12

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    Country:Singapore

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  • Duke-NUS Medical School   Cardiovascular & Metabolic Disorders   Visiting Research Fellow

    2018.3 - 2019.2

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    Country:Singapore

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  • 地方独立行政法人神奈川県立病院機構 神奈川県立循環器呼吸器病センター   医療局循環器内科   医長

    2017.4 - 2018.2

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  • Yokohama City University   Hospital   Assistant Professor

    2015.4 - 2017.3

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    Country:Japan

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  • Yokohama City University

    2017.4 - 2022.3

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  • 日本赤十字社東京都支部 大森赤十字病院   循環器内科

    2013.2 - 2015.3

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    Country:Japan

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  • Yokohama City University   Graduate School of Medicine, Graduate

    2013.2 - 2015.3

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    Country:Japan

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  • Yokohama City University   Hospital, Cardiovascular Medicine

    2009.4 - 2013.1

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    Country:Japan

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  • International University of Health and Welfare   IUHW Atami Hospital

    2007.4 - 2009.3

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    Country:Japan

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  • 横浜市立大学医学部循環器・腎臓内科学教室(旧第二内科学教室)入局

    2007.4

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    Country:Japan

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  • 海老名総合病院   初期臨床研修

    2005.4 - 2007.3

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    Country:Japan

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Professional Memberships

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Committee Memberships

  • 日本高血圧学会   AMED 事業「デジタル技術を活用した生涯にわたる血圧管理に関する指針の研究開発」 システマティックレビュー委員  

    2023.5 - 2025.4   

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    Committee type:Academic society

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  • 日本高血圧学会   基礎研究推進部会  

    2023.1   

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  • 日本高血圧学会   フューチャープラン委員会「Onco-Hypertension」ワーキンググループ  

    2022.6   

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    Committee type:Academic society

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Papers

  • Dietary diversity and its association with hypertension risk: insights from the China health and nutrition survey. Invited Reviewed International journal

    Shintaro Minegishi

    Hypertension research : official journal of the Japanese Society of Hypertension   48 ( 3 )   1029 - 1031   2025.3

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-025-02119-w

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  • Prevalence and Management of Hypertension in Childhood, Adolescent, and Young Adult Cancer Survivors: A Systematic Review and Meta-analysis Reviewed

    Asai, Masanari, Tokoro, Takumi, Komura Naohiro, Minegishi Shintaro, Horigome, Akira, Hattori, Kyoko, Ishii, Satoshi, Hanajima, Yohei, Okazaki, Yoshinori, Horita, Nobuyuki, Ishigami, Tomoaki, Hibi, Kiyoshi, Yano, Yuichiro, Nishiyama, Akira, Node, Koichi

    Hypertension Research   in press   2025

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

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  • Water Conservation Overrides Osmotic Diuresis During SGLT2 Inhibition in Patients With Heart Failure. Reviewed International journal

    Adriana Marton, Seyed Ehsan Saffari, Manfred Rauh, Ruo-Ning Sun, Armin M Nagel, Peter Linz, Tzy Tiing Lim, Kaoru Takase-Minegishi, Anastacia Pajarillaga, Sharon Saw, Norihiko Morisawa, Wan Keat Yam, Shintaro Minegishi, John J Totman, Serena Teo, Louis L Y Teo, Choon Ta Ng, Kento Kitada, Johannes Wild, Jean-Paul Kovalik, Friedrich C Luft, Peter J Greasley, Calvin W L Chin, David K L Sim, Jens Titze

    Journal of the American College of Cardiology   83 ( 15 )   1386 - 1398   2024.4

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    BACKGROUND: Sodium-glucose cotransporter 2 inhibitors are believed to improve cardiac outcomes due to their osmotic diuretic potential. OBJECTIVES: The goal of this study was to test the hypothesis that vasopressin-driven urine concentration overrides the osmotic diuretic effect of glucosuria induced by dapagliflozin treatment. METHODS: DAPA-Shuttle1 (Hepato-renal Regulation of Water Conservation in Heart Failure Patients With SGLT-2 Inhibitor Treatment) was a single-center, double-blind, randomized, placebo-controlled trial, in which patients with chronic heart failure NYHA functional classes I/II and reduced ejection fraction were randomly assigned to receive dapagliflozin 10 mg daily or placebo (1:1) for 4 weeks. The primary endpoint was change from baseline in urine osmolyte concentration. Secondary endpoints included changes in copeptin levels and solute free water clearance. RESULTS: Thirty-three randomized, sodium-glucose cotransporter 2 inhibitor-naïve participants completed the study, 29 of whom (placebo: n = 14; dapagliflozin: n = 15) provided accurate 24-hour urine collections (mean age 59 ± 14 years; left ventricular ejection fraction 31% ± 9%). Dapagliflozin treatment led to an isolated increase in urine glucose excretion by 3.3 mmol/kg/d (95% CI: 2.51-4.04; P < 0.0001) within 48 hours (early) which persisted after 4 weeks (late; 2.7 mmol/kg/d [95% CI: 1.98-3.51]; P < 0.0001). Dapagliflozin treatment increased serum copeptin early (5.5 pmol/L [95% CI: 0.45-10.5]; P < 0.05) and late (7.8 pmol/L [95% CI: 2.77-12.81]; P < 0.01), leading to proportional reductions in free water clearance (early: -9.1 mL/kg/d [95% CI: -14 to -4.12; P < 0.001]; late: -11.0 mL/kg/d [95% CI: -15.94 to -6.07; P < 0.0001]) and elevated urine concentrations (late: 134 mmol/L [95% CI: 39.28-229.12]; P < 0.01). Therefore, urine volume did not significantly increase with dapagliflozin (mean difference early: 2.8 mL/kg/d [95% CI: -1.97 to 7.48; P = 0.25]; mean difference late: 0.9 mL/kg/d [95% CI: -3.83 to 5.62]; P = 0.70). CONCLUSIONS: Physiological-adaptive water conservation eliminated the expected osmotic diuretic potential of dapagliflozin and thereby prevented a glucose-driven increase in urine volume of approximately 10 mL/kg/d · 75 kg = 750 mL/kg/d. (Hepato-renal Regulation of Water Conservation in Heart Failure Patients With SGLT-2 Inhibitor Treatment [DAPA-Shuttle1]; NCT04080518).

    DOI: 10.1016/j.jacc.2024.02.020

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  • Future Prospects of Onco-Hypertension. Reviewed International journal

    Shintaro Minegishi, Akira Nishiyama, Yuichiro Yano, Koichi Node

    Hypertension (Dallas, Tex. : 1979)   80 ( 7 )   e123-e124   2023.7

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    DOI: 10.1161/HYPERTENSIONAHA.123.21011

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  • Immune Checkpoint Inhibitors Do Not Increase Short-Term Risk of Hypertension in Cancer Patients: a Systematic Literature Review and Meta-Analysis. Reviewed International journal

    Shintaro Minegishi, Sho Kinguchi, Nobuyuki Horita, Ho Namkoong, Alexandros Briasoulis, Tomoaki Ishigami, Kouichi Tamura, Akira Nishiyama, Yuichiro Yano

    Hypertension (Dallas, Tex. : 1979)   79 ( 11 )   2611 - 2621   2022.11

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    BACKGROUND: Immune checkpoint inhibitors (ICIs) are becoming widely used for novel cancer treatments. Immune-related adverse events, including cardiac toxicity, are frequently observed following immune checkpoint inhibitor (ICI) use. However, little is known regarding the association between ICIs initiation and hypertension in cancer patients. METHODS: A systematic literature search was performed using PubMed, EMBASE, Cochrane Library, and Web of Science Core Collection. The risk of hypertension associated with ICI initiation in randomized controlled trials (RCTs) was evaluated. Hypertension was categorized according to the Common Terminology Criteria for Adverse Events. The odds ratios of grades I to V and grades III to V hypertension were calculated using a random-effects meta-analysis. RESULTS: Thirty-two RCTs (n=19 810 cancer patients) were included. At a median follow-up of 36 months, the median overall survival was 15 months in the ICI group. ICI initiation was not significantly associated with hypertension (grades I-V: odds ratio, 1.12 [95% CI, 0.96-1.30]; grades III-V: odds ratio, 0.95 [95% CI, 0.78-1.16]). Additionally, no significant differences in hypertension risk were evident in ICI combination therapies with various drugs, including anti-VEGF (vascular endothelial growth factor) agents. In a subgroup analysis based on clinical setting (placebo RCT versus nonplacebo RCT), there were discrepancies between the results obtained with different methodologies, with patients in the nonplacebo RCTs having higher grades I-V hypertension (I2=88.6%, P for heterogeneity=0.003). CONCLUSIONS: ICI initiation was not associated with short-term risk of hypertension in cancer patients, and the association was similar regardless of concomitant treatment with other anticancer drugs.

    DOI: 10.1161/HYPERTENSIONAHA.122.19865

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  • Sodium Handling and Interaction in Numerous Organs. Invited Reviewed International journal

    Shintaro Minegishi, Friedrich C Luft, Jens Titze, Kento Kitada

    American journal of hypertension   33 ( 8 )   687 - 694   2020.8

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    Salt (NaCl) is a prerequisite for life. Excessive intake of salt, however, is said to increase disease risk, including hypertension, arteriosclerosis, heart failure, renal disease, stroke, and cancer. Therefore, considerable research has been expended on the mechanism of sodium handling based on the current concepts of sodium balance. The studies have necessarily relied on relatively short-term experiments and focused on extremes of salt intake in humans. Ultra-long-term salt balance has received far less attention. We performed long-term salt balance studies at intakes of 6, 9, and 12 g/day and found that although the kidney remains the long-term excretory gate, tissue and plasma sodium concentrations are not necessarily the same and that urinary salt excretion does not necessarily reflect total-body salt content. We found that to excrete salt, the body makes a great effort to conserve water, resulting in a natriuretic-ureotelic principle of salt excretion. Of note, renal sodium handling is characterized by osmolyte excretion with anti-parallel water reabsorption, a state-of-affairs that is achieved through the interaction of multiple organs. In this review, we discuss novel sodium and water balance concepts in reference to our ultra-long-term study. An important key to understanding body sodium metabolism is to focus on water conservation, a biological principle to protect from dehydration, since excess dietary salt excretion into the urine predisposes to renal water loss because of natriuresis. We believe that our research direction is relevant not only to salt balance but also to cardiovascular regulatory mechanisms.

    DOI: 10.1093/ajh/hpaa049

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  • An Isoform of Nedd4-2 Plays a Pivotal Role in Electrophysiological Cardiac Abnormalities. Reviewed International journal

    Shintaro Minegishi, Tomoaki Ishigami, Hisho Kawamura, Tabito Kino, Lin Chen, Rie Nakashima-Sasaki, Hiroshi Doi, Kengo Azushima, Hiromichi Wakui, Yumi Chiba, Kouichi Tamura

    International journal of molecular sciences   18 ( 6 )   1268   2017.6

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    DOI: 10.3390/ijms18061268

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  • An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice. Reviewed International journal

    Shintaro Minegishi, Tomoaki Ishigami, Tabito Kino, Lin Chen, Rie Nakashima-Sasaki, Naomi Araki, Keisuke Yatsu, Megumi Fujita, Satoshi Umemura

    Scientific reports   6   27137 - 27137   2016.6

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    Epithelial sodium channels (ENaCs) play critical roles in the maintenance of fluid and electrolyte homeostasis, and their genetic abnormalities cause one type of hereditary salt-sensitive hypertension, Liddle syndrome. As we reported previously, both human and rodent Nedd4L/Nedd4-2 showed molecular diversity, with and without a C2 domain in their N-terminal. Nedd4L/Nedd4-2 isoforms with a C2 domain are hypothesized to be related closely to ubiquitination of ENaCs. We generated Nedd4-2 C2 domain knockout mice. We demonstrate here that loss of Nedd4-2 C2 isoform causes salt-sensitive hypertension under conditions of a high dietary salt intake in vivo. The knockout mice had reduced urinary sodium excretion, osmotic pressure and increased water intake and urine volume with marked dilatation of cortical tubules while receiving a high salt diet. To the contrary, there was no difference in metabolic data between wild-type and knockout mice receiving a normal control diet. In the absence of Nedd4-2 C2 domain, a high salt intake accelerated ENaC expression. Coimmunoprecipitation studies revealed suppressed ubiquitination for ENaC with a high salt intake. Taken together, our findings demonstrate that during a high oral salt intake the Nedd4-2 C2 protein plays a pivotal role in maintaining adaptive salt handling in the kidney.

    DOI: 10.1038/srep27137

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  • Effectiveness of self-monitoring devices measuring the urinary sodium-to-potassium ratio, urinary salt (sodium) excretion, or salt concentration in foods for blood pressure management: a systematic review and meta-analysis. Reviewed International journal

    Takashi Hisamatsu, Kohei Ueda, Kimika Arakawa, Shintaro Minegishi, Yukiko Okami, Minako Kinuta, Keiko Kondo, Hiroshige Jinnouchi, Maho Ishihara, Makiko Abe, Atsushi Sakima, Katsuyuki Miura, Hisatomi Arima

    Hypertension research : official journal of the Japanese Society of Hypertension   in press   2025.2

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    Self-monitoring devices that measure the urinary sodium-to-potassium (Na/K) ratio, urinary salt or sodium excretion, or salt concentration in foods have emerged as tools that can guide dietary adjustments for blood pressure (BP) control. This systematic review and meta-analysis investigated whether these self-monitoring devices can help to control BP in adults. The PubMed, Cochrane Library, and Ichushi-Web databases were searched to identify randomized controlled trials that compared the effect of these devices (with or without additional dietary education) plus usual care on BP with that of usual care alone. The pooled effect of weighted mean difference between the intervention and control groups at the end of follow-up was estimated by random-effects meta-analysis. The primary outcome was the change in BP. Secondary outcomes included changes in the urinary Na/K ratio, and sodium and potassium excretions. Of 1525 studies screened, eight (with 1442 participants) were eligible for inclusion. Meta-analysis showed greater reductions in systolic BP by 2.45 (95% confidence interval, 0.04, 4.86) mmHg and diastolic BP by 1.38 (-0.15, 2.90) mmHg in the intervention vs. control groups. However, heterogeneity was high (I² = 69.4% for systolic BP and 65.1% for diastolic BP). The BP-lowering effect was not statistically different across different follow-up durations (4 weeks or 2-6 months) and intervention approaches (self-monitoring alone or combined with dietary education) (all p values for heterogeneity >0.1). Reductions in the urinary Na/K ratio and sodium excretion were greater in the intervention group. Self-monitoring devices may assist with BP reduction by promoting decreased sodium intake and increased potassium intake.

    DOI: 10.1038/s41440-025-02124-z

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  • Current Status and Future Perspective of Onco-Hypertension. Invited Reviewed International journal

    Tatsuhiko Azegami, Hidehiro Kaneko, Shintaro Minegishi, Yuta Suzuki, Hiroyuki Morita, Katsuhito Fujiu, Norihiko Takeda, Takashi Yokoo, Yuichiro Yano, Kaori Hayashi, Akira Nishiyama, Koichi Node

    American journal of hypertension   38 ( 1 )   1 - 6   2024.12

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    BACKGROUND: Hypertension and cancer are both increasing with age. Recently, the new concept of "Onco-Hypertension" has been proposed to address the mutual risks posed by hypertension and cancer and to provide comprehensive care for patients with these two conditions in an aging society. METHODS: In this review, we provide an overview of the current status and future perspective of the "Onco-Hypertension," including our research findings. RESULTS: Hypertension and cancer share common risk factors and may be interrelated in pathogenesis: Hypertension is involved in the development of certain cancers, and cancer survivors have a higher incidence of hypertension. With recent advances in cancer therapy, the number of cancer survivors has increased. Cancer survivors not only have a higher risk of incident hypertension but also an increased risk of future cardiovascular events, highlighting the growing importance of comprehensive care. CONCLUSIONS: There exists a diverse array of epidemiological and pathophysiological relationships between hypertension and cancer. It is imperative to move the emerging scientific field of "Onco-Hypertension" forward through relentless research efforts.

    DOI: 10.1093/ajh/hpae099

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  • The evaluation value of non-invasive indices of arterial stiffness in the early stage of coronary artery disease: Preliminary results from an exploratory study. Reviewed

    Fei Wang, Hui Zhang, Kotaro Uchida, Takuya Sugawara, Shintaro Minegishi, Hiroshi Doi, Rie Nakashima-Sasaki, Lin Chen, Tomoaki Ishigami

    Journal of Vascular Diseases   2024.8

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  • A Noninvasive Arterial Stiffness Index to Estimate the Severity of Coronary Atherosclerosis in Patients Undergoing Coronary Angiography

    Kotaro Uchida, lin chen, Shintaro Minegishi, Takuya Sugawara, Rie Sasaki-Nakashima, Kentaro Arakawa, Hiroshi Doi, Tabito Kino, Naoki Tada, Sho Tarumi, Noriyuki Kawaura, Kouichi Tamura, Kiyoshi Hibi, Tomoaki Ishigami

    Journal of Vascular Diseases   2024.5

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    DOI: 10.3390/jvd3020014

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  • Impact of Hypertension in Cancer Patients Treated With Anti-Vascular Endothelial Growth Factor Therapy. Invited Reviewed

    Shintaro Minegishi

    Circulation journal : official journal of the Japanese Circulation Society   88 ( 2 )   226 - 227   2024.1

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    DOI: 10.1253/circj.CJ-22-0825

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  • Cardiotoxicity Associated with Immune Checkpoint Inhibitors. Invited Reviewed International journal

    Shintaro Minegishi, Nobuyuki Horita, Tomoaki Ishigami, Kiyoshi Hibi

    Cancers   15 ( 22 )   2023.11

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    Immune checkpoint inhibitors (ICIs) have shown significant efficacy in various cancers, including non-small cell lung cancer, small cell lung cancer, melanoma, classical Hodgkin lymphoma, head and neck squamous cell carcinoma, urothelial cancer, and renal cell carcinoma [...].

    DOI: 10.3390/cancers15225487

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  • Use of calcium channel blockers does not increase breast cancer risk: findings from a nationwide population-based cohort study in Taiwan. Invited Reviewed International journal

    Shintaro Minegishi

    Hypertension research : official journal of the Japanese Society of Hypertension   46 ( 10 )   2312 - 2314   2023.10

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    DOI: 10.1038/s41440-023-01382-z

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  • Mfsd2a-mediated lysolipid transport is important for renal recovery after acute kidney injury. Reviewed International journal

    Randy Y J Loke, Cheen Fei Chin, Gao Liang, Bernice H Wong, Dwight L A Galam, Bryan C Tan, Geok-Lin Chua, Shintaro Minegishi, Norihiko Morisawa, Iulia Sidorov, Bram Heijs, Jens Titze, Markus R Wenk, Federico Torta, David L Silver

    Journal of lipid research   64 ( 8 )   100416 - 100416   2023.8

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    Acute kidney injury (AKI) is a global public health concern with high mortality and morbidity. In ischemic reperfusion injury (IRI), a main cause of AKI, the brush border membrane of S3 proximal tubules (PT) is lost to the tubular lumen. How injured tubules reconstitute lost membrane lipids during renal recovery is not known. Here, we identified Mfsd2a, a sodium-dependent lysophosphatidylcholine (LPC) transporter, to be expressed specifically in the basolateral membrane of S3 PT. Using an in vivo activity probe for Mfsd2a, transport activity was found to be specific to the S3 PT. Mice with haploinsufficiency of Mfsd2a exhibited delayed recovery of renal function after acute IRI, with depressed urine osmolality and elevated levels of histological markers of damage, fibrosis and inflammation, findings corroborated by transcriptomic analysis. Lipidomics revealed deficiency in docosahexaenoic acid (DHA) containing phospholipids in Mfsd2a haploinsufficiency. Treatment of Mfsd2a haploinsufficient mice with LPC-DHA improved renal function and reduced markers of injury, fibrosis and inflammation. Additionally, LPC-DHA treatment restored S3 brush border membrane architecture, and normalized DHA containing phospholipid content. These findings indicate that Mfsd2a mediated transport of LPC-DHA is limiting for renal recovery after AKI and suggest that LPC-DHA could be a promising dietary supplement for improving recovery following AKI.

    DOI: 10.1016/j.jlr.2023.100416

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  • Economic evaluation of a new blood pressure target for hypertensive patients in Taiwan. Invited Reviewed International journal

    Shintaro Minegishi, Akira Nishiyama

    Hypertension research : official journal of the Japanese Society of Hypertension   46 ( 3 )   784 - 786   2023.3

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    DOI: 10.1038/s41440-022-01125-6

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  • Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure Reviewed International journal

    森澤紀彦, KOVARIK Johannes J, WILD Johannes, ADRIANA Marton, 峯岸薫, 峯岸慎太郎, DAUB Steffen, SANDS Jeff M, KOVALIK Jean-Paul, RAUH Manfred, LUFT Friedrich, 西山成, 中野大介, 北田研人, 北田研人, TITZE Jens, TITZE Jens

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   43rd ( 1 )   e13629   2021.5

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    AIM: We have reported earlier that a high salt intake triggered an aestivation-like natriuretic-ureotelic body water conservation response that lowered muscle mass and increased blood pressure. Here we tested the hypothesis that a similar adaptive water conservation response occurs in experimental chronic renal failure. METHODS: In four subsequent experiments in Sprague Dawley rats, we used surgical 5/6 renal mass reduction (5/6 Nx) to induce chronic renal failure. We studied solute and water excretion in 24-h metabolic cage experiments, chronic blood pressure by radiotelemetry, chronic metabolic adjustment in liver and skeletal muscle by metabolomics and selected enzyme activity measurements, body Na+ , K+ , and water by dry ashing, and acute transepidermal water loss in conjunction with skin blood flow and intra-arterial blood pressure. RESULTS: 5/6 Nx rats were polyuric, because their kidneys could not sufficiently concentrate the urine. Physiological adaptation to this renal water loss included mobilization of nitrogen and energy from muscle for organic osmolyte production, elevated norepinephrine and copeptin levels with reduced skin blood flow, which by means of compensation reduced their transepidermal water loss. This complex physiologic-metabolic adjustment across multiple organs allowed the rats to stabilize their body water content despite persisting renal water loss, albeit at the expense of hypertension and catabolic mobilization of muscle protein. CONCLUSION: Physiological adaptation to body water loss, termed aestivation, is an evolutionary conserved survival strategy and an under-studied research area in medical physiology, which besides hypertension and muscle mass loss in chronic renal failure may explain many otherwise unexplainable phenomena in medicine.

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  • Effects of Erythropoietin-Stimulating Agents on Blood Pressure in Patients with Non-Dialysis CKD and Renal Anemia. Reviewed International journal

    Kohji Ohki, Hiromichi Wakui, Kazushi Uneda, Kengo Azushima, Kotaro Haruhara, Sho Kinguchi, Shingo Urate, Takayuki Yamada, Takahiro Yamaji, Ryu Kobayashi, Tomohiko Kanaoka, Shintaro Minegishi, Tomoaki Ishigami, Tetsuya Fujikawa, Yoshiyuki Toya, Kouichi Tamura

    Kidney diseases (Basel, Switzerland)   6 ( 4 )   299 - 308   2020.7

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    Introduction: Erythropoietin-stimulating agents (ESAs) are used to treat renal anemia in patients with non-dialysis CKD, but this can lead to increases in blood pressure (BP). Objective: We investigated the effects of continuous erythropoietin receptor activator (CERA) and darbepoetin alfa (DA) on office/ambulatory BP in 36 patients with non-dialysis CKD and renal anemia who did not receive ESA treatment. Methods: Participants were randomly assigned to CERA or DA, and received ESA treatment for 24 weeks. ESA doses were adjusted to maintain hemoglobin (Hb) at 10-12 g/dL. Primary outcomes were office/ambulatory BP after 24 weeks of ESA treatment. Hb levels were within the target range at 24 weeks. Results: Office/ambulatory BP, renal function, and other parameters were not significantly different between groups. However, we could not exclude the possibility that differences may exist because our sample size was small. Therefore, we also performed analysis of all of the data that were compiled from the groups of per-protocol population. Although office/ambulatory BP profiles had not worsened after 24 weeks of ESA treatment, more than half of the patients required an increase in the antihypertensive agent dose. Conclusions: CERA and DA may have similar effects on BP profiles in patients with non-dialysis CKD and renal anemia. ESA treatment often requires increases in the doses of antihypertensive agents.

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  • Regulators of Epithelial Sodium Channels in Aldosterone-Sensitive Distal Nephrons (ASDN): Critical Roles of Nedd4L/Nedd4-2 and Salt-Sensitive Hypertension. Reviewed International journal

    Tomoaki Ishigami, Tabito Kino, Shintaro Minegishi, Naomi Araki, Masanari Umemura, Hisako Ushio, Sae Saigoh, Michiko Sugiyama

    International journal of molecular sciences   21 ( 11 )   2020.5

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    Ubiquitination is a representative, reversible biological process of the post-translational modification of various proteins with multiple catalytic reaction sequences, including ubiquitin itself, in addition to E1 ubiquitin activating enzymes, E2 ubiquitin conjugating enzymes, E3 ubiquitin ligase, deubiquitinating enzymes, and proteasome degradation. The ubiquitin-proteasome system is known to play a pivotal role in various molecular life phenomena, including the cell cycle, protein quality, and cell surface expressions of ion-transporters. As such, the failure of this system can lead to cancer, neurodegenerative diseases, cardiovascular diseases, and hypertension. This review article discusses Nedd4-2/NEDD4L, an E3-ubiquitin ligase involved in salt-sensitive hypertension, drawing from detailed genetic dissection analysis and the development of genetically engineered mice model. Based on our analyses, targeting therapeutic regulations of ubiquitination in the fields of cardio-vascular medicine might be a promising strategy in future. Although the clinical applications of this strategy are limited, compared to those of kinase systems, many compounds with a high pharmacological activity were identified at the basic research level. Therefore, future development could be expected.

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  • Effects of Rikkunshito treatment on renal fibrosis/inflammation and body weight reduction in a unilateral ureteral obstruction model in mice. Reviewed International journal

    Hiromichi Wakui, Takahiro Yamaji, Kengo Azushima, Kazushi Uneda, Kotaro Haruhara, Akiko Nakamura, Kohji Ohki, Sho Kinguchi, Ryu Kobayashi, Shingo Urate, Toru Suzuki, Daisuke Kamimura, Shintaro Minegishi, Tomoaki Ishigami, Tomohiko Kanaoka, Kohei Matsuo, Tomoyuki Miyazaki, Tetsuya Fujikawa, Akio Yamashita, Kouichi Tamura

    Scientific reports   10 ( 1 )   1782 - 1782   2020.2

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    Chronic kidney disease (CKD) progresses to end-stage renal failure via renal tubulointerstitial fibrosis. Malnutrition, inflammation, and arteriosclerosis interact to exacerbate the poor prognosis of CKD, and their effective management is thus essential. The traditional Japanese medicine Rikkunshito (RKT) exerts appetite-stimulating effects via ghrelin, which attenuates inflammation and fibrosis. We evaluated the therapeutic effect of RKT in unilateral ureter obstruction (UUO)-induced renal fibrosis/inflammation and body weight loss in mice. UUO and sham-operated mice were fed a standard diet or diet containing 3.0% RKT. Renal fibrosis was investigated by histopathology and macrophage infiltration was determined by immunohistochemistry. Expression levels of genes associated with fibrosis, inflammation, ghrelin, and mitochondrial function were determined by quantitative reverse transcription-polymerase chain reaction and western blot analyses. RKT treatment partially prevented UUO-induced weight loss but failed to attenuate renal fibrosis and inflammation. Renal expression of sirtuin 1, a ghrelin-downstream signalling molecule, and gene expression of peroxisome proliferator-activated receptor-γ coactivator 1α and Bcl-2/adenovirus E1B interacting protein 3 were unaffected by RKT. These results indicate that RKT inhibits weight loss but does not improve renal fibrosis or inflammation in a rapidly progressive renal fibrosis mouse model. RKT may have a protective effect on weight loss associated with CKD.

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  • Native T1 time and extracellular volume fraction in differentiation of normal myocardium from non-ischemic dilated and hypertrophic cardiomyopathy myocardium: A systematic review and meta-analysis. Reviewed International journal

    Shintaro Minegishi, Shingo Kato, Kaoru Takase-Minegishi, Nobuyuki Horita, Kengo Azushima, Hiromichi Wakui, Tomoaki Ishigami, Masami Kosuge, Kazuo Kimura, Kouichi Tamura

    International journal of cardiology. Heart & vasculature   25   100422 - 100422   2019.12

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    Background: Both native T1 time and extracellular volume (ECV) fraction have been shown to be important measures for the detection of myocardial fibrosis. However, ECV determination requires the administration of an intravenous contrast agent, whereas native T1 mapping can be performed without a contrast agent. Methods: Here, we conducted a meta-analysis of myocardial native T1 data obtained for non-ischemic cardiomyopathy (NIC) patients and controls. A literature review included studies that applied T1 mapping using modified Look-Locker inversion recovery to measure myocardial fibrosis, and the results were validated by comparing datasets for dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) patients and healthy controls (HCs). Results: We identified 16 eligible studies. Pooled mean differences (MDs) and 95% confidence intervals (CIs) were estimated as follows. Native T1 at 1.5-T, DCM vs. HC: MD = 45.26 (95% CI: 30.92-59.59); HCM vs. HC: MD = 47.09 (95% CI: 32.42-61.76). Native T1 at 3.0-T, DCM vs. HC: MD = 82.52 (95% CI: 47.60-117.44); HCM vs. HC: MD = 115.87 (95% CI: 50.71-181.04). ECV at 1.5-T, DCM vs. HC: MD = 4.26 (95% CI: 3.06-5.46); HCM vs. HC: MD = 1.49 (95% CI: -1.45-4.43). ECV at 3.0-T, DCM vs. HC: MD = 8.40 (95% CI: 2.94-13.86); HCM vs. HC: MD = 8.02 (95% CI: 5.45-1-0.59). Conclusion: In conclusion, native T1 values were significantly different between NIC patients and controls. Native T1 mapping may be a useful noninvasive method to detect diffuse myocardial fibrosis in NIC patients.

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  • Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice. Reviewed International journal

    Kengo Azushima, Kazushi Uneda, Hiromichi Wakui, Kohji Ohki, Kotaro Haruhara, Ryu Kobayashi, Sona Haku, Sho Kinguchi, Takahiro Yamaji, Shintaro Minegishi, Tomoaki Ishigami, Akio Yamashita, Kouichi Tamura

    Scientific reports   9 ( 1 )   6201 - 6201   2019.4

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  • Effects of ATRAP in Renal Proximal Tubules on Angiotensin-Dependent Hypertension. Reviewed International journal

    Sho Kinguchi, Hiromichi Wakui, Kengo Azushima, Kotaro Haruhara, Tomoyuki Koguchi, Kohji Ohki, Kazushi Uneda, Miyuki Matsuda, Sona Haku, Takahiro Yamaji, Takayuki Yamada, Ryu Kobayashi, Shintaro Minegishi, Tomoaki Ishigami, Akio Yamashita, Tetsuya Fujikawa, Kouichi Tamura

    Journal of the American Heart Association   8 ( 8 )   e012395   2019.4

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    Background We have previously shown that ATRAP (angiotensin II receptor-associated protein; Agtrap) interacts with AT1R (angiotensin II type 1 receptor) and promotes constitutive internalization of AT 1R so as to inhibit hyperactivation of its downstream signaling. In response to angiotensin II , systemic ATRAP deficiency exacerbates angiotensin II -mediated hypertension via hyperactivation of renal tubular AT 1R. Although ATRAP expression is abundant in renal proximal tubules, little is known about the actual function of renal proximal tubule ATRAP in angiotensin-mediated hypertension. Methods and Results In this study, we examined the in vivo functional role of renal proximal tubule ATRAP in angiotensin-dependent hypertension. We succeeded in generating proximal tubule-specific ATRAP knockout ( PT - KO ) mice for the first time using the Cre/loxP system with Pepck-Cre. Detailed analysis of renal ATRAP expression in PT - KO mice estimated by immunohistochemical and laser-capture microdissection analysis revealed that ATRAP mRNA expression decreased by ≈80% in proximal regions of the nephron in PT - KO mice compared with wild-type ( WT ) mice. We compared blood pressure of PT - KO and WT mice using both tail-cuff and radiotelemetric methods. Blood pressure of PT - KO mice was comparable with that of WT mice at baseline. Moreover, no significant differences were noted in pressor response to angiotensin II (600 ng/kg per min or 1000 ng/kg per minute) infusion between PT - KO and WT mice. In addition, angiotensin II -mediated cardiac hypertrophy was identical between PT - KO and WT mice. Conclusions ATRAP deficiency in proximal tubules did not exacerbate angiotensin-dependent hypertension in vivo. The results indicate that renal proximal tubule ATRAP has a minor role in angiotensin-dependent hypertension in vivo.

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  • Lubiprostone as a potential therapeutic agent to improve intestinal permeability and prevent the development of atherosclerosis in apolipoprotein E-deficient mice. Reviewed International journal

    Kentaro Arakawa, Tomoaki Ishigami, Michiko Nakai-Sugiyama, Lin Chen, Hiroshi Doi, Tabito Kino, Shintaro Minegishi, Sae Saigoh-Teranaka, Rie Sasaki-Nakashima, Kiyoshi Hibi, Kazuo Kimura, Kouichi Tamura

    PloS one   14 ( 6 )   e0218096   2019

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    The interaction between atherosclerosis and commensal microbes through leaky gut syndrome (LGS), which is characterized by impaired intestinal permeability and the introduction of undesired pathogens into the body, has not been fully elucidated. Our aim was to investigate the potential role of a ClC-2 chloride channel activator, lubiprostone, which is reported to have beneficial effects on LGS, in the development of atherosclerosis in apolipoprotein E-deficient (ApoE-/-) mice. After a 15-week feeding period of a Western diet (WD), ApoE-/- mice were treated with a Western-type diet (WD) alone or WD with oral supplementation of lubiprostone for 10 weeks. This feeding protocol was followed by experimental evaluation of LGS and atherosclerotic lesions in the aorta. In mice with lubiprostone, in vivo translocation of orally administered 4-kDa FITC-dextran was significantly improved, and RNA expression of the epithelial tight junction proteins, Zo-1 and occludin, was significantly up-regulated in the ileum, compared to the WD alone group, suggesting a possible reversal of WD-induced intestinal barrier dysfunction. As a result, WD-induced exacerbation of atherosclerotic lesion formation was reduced by 69% in longitudinally opened aortas and 26% in aortic root regions. In addition, there was a significant decrease in circulating immunoglobulin level, followed by an attenuation of inflammatory responses in the perivascular adipose tissue, as evidenced by reduced expression of pro-inflammatory cytokines and chemokines. Lubiprostone attenuates atherosclerosis by ameliorating LGS-induced inflammation through the restoration of the intestinal barrier. These findings raise the possibility of targeting LGS for the treatment of atherosclerosis.

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  • New non-invasive indexes of arterial stiffness are significantly correlated with severity and complexity of coronary atherosclerosis. Reviewed International journal

    Hiroshi Doi, Tomoaki Ishigami, Rie Nakashima-Sasaki, Tabito Kino, Lin Chen, Kentaro Arakawa, Sae Teranaka, Shintaro Minegishi, Kaito Abe, Toshiyuki Ishikawa, Teruyasu Sugano, Kouichi Tamura

    Clinical and experimental hypertension (New York, N.Y. : 1993)   41 ( 2 )   1 - 7   2018.5

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  • Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue. Reviewed International journal

    Kohji Ohki, Hiromichi Wakui, Nozomu Kishio, Kengo Azushima, Kazushi Uneda, Sona Haku, Ryu Kobayashi, Kotaro Haruhara, Sho Kinguchi, Takahiro Yamaji, Takayuki Yamada, Shintaro Minegishi, Tomoaki Ishigami, Yoshiyuki Toya, Akio Yamashita, Kento Imajo, Atsushi Nakajima, Ikuma Kato, Kenichi Ohashi, Kouichi Tamura

    Scientific reports   8 ( 1 )   2846 - 2846   2018.2

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  • Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile. Reviewed International journal

    Kotaro Haruhara, Hiromichi Wakui, Kengo Azushima, Daisuke Kurotaki, Wataru Kawase, Kazushi Uneda, Sona Haku, Ryu Kobayashi, Kohji Ohki, Sho Kinguchi, Masato Ohsawa, Shintaro Minegishi, Tomoaki Ishigami, Miyuki Matsuda, Akio Yamashita, Hideaki Nakajima, Tomohiko Tamura, Nobuo Tsuboi, Takashi Yokoo, Kouichi Tamura

    Atherosclerosis   269   236 - 244   2018.2

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  • Early Enhanced Leucine-Rich α-2-Glycoprotein-1 Expression in Glomerular Endothelial Cells of Type 2 Diabetic Nephropathy Model Mice. Reviewed International journal

    Sona Haku, Hiromichi Wakui, Kengo Azushima, Kotaro Haruhara, Sho Kinguchi, Kohji Ohki, Kazushi Uneda, Ryu Kobayashi, Miyuki Matsuda, Takahiro Yamaji, Takayuki Yamada, Shintaro Minegishi, Tomoaki Ishigami, Akio Yamashita, Kenichi Ohashi, Kouichi Tamura

    BioMed research international   2018   2817045 - 2817045   2018

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  • Angiotensin II Type 1 Receptor-Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin. Reviewed International journal

    Kazushi Uneda, Hiromichi Wakui, Akinobu Maeda, Kengo Azushima, Ryu Kobayashi, Sona Haku, Kohji Ohki, Kotaro Haruhara, Sho Kinguchi, Miyuki Matsuda, Masato Ohsawa, Shintaro Minegishi, Tomoaki Ishigami, Yoshiyuki Toya, Yoshitoshi Atobe, Akio Yamashita, Satoshi Umemura, Kouichi Tamura

    Journal of the American Heart Association   6 ( 8 )   2017.7

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  • Eplerenone-Resistant Salt-Sensitive Hypertension in Nedd4-2 C2 KO Mice. Reviewed International journal

    Tabito Kino, Tomoaki Ishigami, Tsumugi Murata, Hiroshi Doi, Rie Nakashima-Sasaki, Lin Chen, Michiko Sugiyama, Kengo Azushima, Hiromichi Wakui, Shintaro Minegishi, Kouichi Tamura

    International journal of molecular sciences   18 ( 6 )   2017.6

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  • Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II-infused mice. Reviewed International journal

    Hiromichi Wakui, Koichiro Sumida, Megumi Fujita, Yuta Ohtomo, Masato Ohsawa, Ryu Kobayashi, Kazushi Uneda, Kengo Azushima, Kotaro Haruhara, Keisuke Yatsu, Nobuhito Hirawa, Shintaro Minegishi, Tomoaki Ishigami, Satoshi Umemura, Kouichi Tamura

    Physiological reports   5 ( 11 )   2017.6

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  • ATRAP Expression in Brown Adipose Tissue Does Not Influence the Development of Diet-Induced Metabolic Disorders in Mice. Reviewed International journal

    Kohji Ohki, Hiromichi Wakui, Kengo Azushima, Kazushi Uneda, Sona Haku, Ryu Kobayashi, Kotaro Haruhara, Sho Kinguchi, Miyuki Matsuda, Masato Ohsawa, Akinobu Maeda, Shintaro Minegishi, Tomoaki Ishigami, Yoshiyuki Toya, Akio Yamashita, Satoshi Umemura, Kouichi Tamura

    International journal of molecular sciences   18 ( 3 )   2017.3

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  • Successful prediction of cardiovascular risk by new non-invasive vascular indexes using suprasystolic cuff oscillometric waveform analysis. Reviewed International journal

    Rie Sasaki-Nakashima, Tabito Kino, Lin Chen, Hiroshi Doi, Shintaro Minegishi, Kaito Abe, Teruyasu Sugano, Masataka Taguri, Tomoaki Ishigami

    Journal of cardiology   69 ( 1 )   30 - 37   2017.1

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  • 感染性心内膜炎を合併したStaphylococcus lugdunensisによる化膿性脊椎炎の一例 Reviewed

    峯岸 慎太郎, 持田 泰行, 降旗 修太, 市川 晋也, 福岡 雅浩, 神原 かおり, 新浪 博士, 梅村 敏

    日本集中治療医学会雑誌   24 ( 1 )   9 - 13   2017.1

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  • The current evidence on diagnosis and treatment of acute aortic syndrome. Reviewed International journal

    Shintaro Minegishi, Hiroki Watanabe, Nobuyuki Horita, Yuji Shibata, Takeshi Kaneko, Tomoaki Ishigami

    Journal of thoracic disease   8 ( 12 )   E1617-E1619 - E1619   2016.12

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  • Commensal Microbe-specific Activation of B2 Cell Subsets Contributes to Atherosclerosis Development Independently of Lipid Metabolism. Reviewed International journal

    Lin Chen, Tomoaki Ishigami, Rie Nakashima-Sasaki, Tabito Kino, Hiroshi Doi, Shintaro Minegishi, Satoshi Umemura

    EBioMedicine   13   237 - 247   2016.11

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    The relation between B2 cells and commensal microbes during atherosclerosis remains largely unexplored. Here we show that under hyperlipidemic conditions intestinal microbiota resulted in recruitment and ectopic activation of B2 cells in perivascular adipose tissue, followed by an increase in circulating IgG, promoting disease development. In contrast, disruption of the intestinal microbiota by a broad-spectrum antibiotic cocktail (AVNM) led to the attenuation of atherosclerosis by suppressing B2 cells, despite the persistence of serum lipid abnormalities. Furthermore, pharmacological depletion of B2 cells with an anti-B2-cell surface CD23 antibody also attenuated commensal microbe-induced atherosclerosis. Moreover, expression analysis of TLR-signaling-related genes in the activated B2 cell subsets, assessed using the Toll-Like Receptor Signaling Pathway RT2 Profiler PCR Array, confirmed activation of the B2-cell autoantibody-production axis, which was associated with an increased capacity of B2 cells to bind to intestinal microbiota. Together, our findings reveal the critical role of commensal microbe-specific activation of B2 cells in the development of atherogenesis through lipid metabolism-independent mechanisms.

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  • Diagnostic test accuracy of D-dimer for acute aortic syndrome: systematic review and meta-analysis of 22 studies with 5000 subjects. Reviewed International journal

    Hiroki Watanabe, Nobuyuki Horita, Yuji Shibata, Shintaro Minegishi, Erika Ota, Takeshi Kaneko

    Scientific reports   6   26893 - 26893   2016.5

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    Diagnostic test accuracy of D-dimer for acute aortic dissection (AAD) has not been evaluated by meta-analysis with the bivariate model methodology. Four databases were electrically searched. We included both case-control and cohort studies that could provide sufficient data concerning both sensitivity and specificity of D-dimer for AAD. Non-English language articles and conference abstract were allowed. Intramural hematoma and penetrating aortic ulcer were regarded as AAD. Based on 22 eligible articles consisting of 1140 AAD subjects and 3860 non-AAD subjects, the diagnostic odds ratio was 28.5 (95% CI 17.6-46.3, I(2) = 17.4%) and the area under curve was 0.946 (95% CI 0.903-0.994). Based on 833 AAD subjects and 1994 non-AAD subjects constituting 12 studies that used the cutoff value of 500 ng/ml, the sensitivity was 0.952 (95% CI 0.901-0.978), the specificity was 0.604 (95% CI 0.485-0.712), positive likelihood ratio was 2.4 (95% CI 1.8-3.3), and negative likelihood ratio was 0.079 (95% CI 0.036-0.172). Sensitivity analysis using data of three high-quality studies almost replicated these results. In conclusion, D-dimer has very good overall accuracy. D-dimer <500 ng/ml largely decreases the possibility of AAD. D-dimer >500 ng/ml moderately increases the possibility of AAD.

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  • Genetic variation in NEDD4L, salt sensitivity, and hypertension: human NEDD4L rs4149601 G allele generates evolutionary new isoform I with C2 domain. Reviewed International journal

    Tomoaki Ishigami, Naomi Araki, Shintaro Minegishi, Masanari Umemura, Satoshi Umemura

    Journal of hypertension   32 ( 9 )   1905 - 1905   2014.9

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  • Identification of bona fide alternative renin transcripts expressed along cortical tubules and potential roles in promoting insulin resistance in vivo without significant plasma renin activity elevation. Reviewed International journal

    Tomoaki Ishigami, Tabito Kino, Lin Chen, Shintaro Minegishi, Naomi Araki, Masanari Umemura, Kaito Abe, Rie Sasaki, Hisako Yamana, Satoshi Umemura

    Hypertension (Dallas, Tex. : 1979)   64 ( 1 )   125 - 33   2014.7

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  • Anti-interleukin-5 and multiple autoantibodies are associated with human atherosclerotic diseases and serum interleukin-5 levels. Reviewed International journal

    Tomoaki Ishigami, Kaito Abe, Ichiro Aoki, Shintaro Minegishi, Akihide Ryo, Satoko Matsunaga, Kazuhiro Matsuoka, Hiroyuki Takeda, Tatsuya Sawasaki, Satoshi Umemura, Yaeta Endo

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology   27 ( 9 )   3437 - 45   2013.9

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  • Renin Angiotensin Antagonists Normalize Aberrant Activation of Epithelial Sodium Channels in Sodium-Sensitive Hypertension Reviewed International journal

    Hisako Ushio-Yamana, Shintaro Minegishi, Tomoaki Ishigami, Naomi Araki, Masanari Umemura, Koichi Tamura, Emi Maeda, Yutaka Kakizoe, Kenichiro Kitamura, Satoshi Umemura

    NEPHRON EXPERIMENTAL NEPHROLOGY   122 ( 3-4 )   95 - 102   2012

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  • Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L. Reviewed International journal

    Naomi Araki, Tomoaki Ishigami, Hisako Ushio, Shintaro Minegishi, Masanari Umemura, Yohei Miyagi, Ichiro Aoki, Hiroko Morinaga, Koichi Tamura, Yoshiyuki Toya, Kazuaki Uchino, Satoshi Umemura

    Biochemical and biophysical research communications   388 ( 2 )   290 - 6   2009.10

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  • Erratum: Utility and feasibility of a new programmable home blood pressure monitoring device for the assessment of nighttime blood pressure (Clinical and Experimental Nephrology DOI: 10.1007/s10157-009-0192-4) Reviewed

    Hisako Ushio, Tomoaki Ishigami, Naomi Araki, Shintaro Minegishi, Koichi Tamura, Yasuko Okano, Kazuaki Uchino, Osamu Tochikubo, Satoshi Umemura

    Clinical and Experimental Nephrology   13 ( 5 )   486   2009.10

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  • Utility and feasibility of a new programmable home blood pressure monitoring device for the assessment of nighttime blood pressure. Reviewed

    Hisako Ushio, Tomoaki Ishigami, Naomi Araki, Shintaro Minegishi, Koichi Tamura, Yasuko Okano, Kazuaki Uchino, Osamu Tochikubo, Satoshi Umemura

    Clinical and experimental nephrology   13 ( 5 )   480 - 485   2009.10

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    DOI: 10.1007/s10157-009-0192-4

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  • [A case of a primary gastrointestinal stromal tumor (GIST) found in the greater omentum of a 99-year-old woman]. Reviewed

    Shintaro Minegishi, Tomohiko Shigemasa, Shunichi Kobayashi, Fukashi Kasuya

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   46 ( 2 )   179 - 83   2009.3

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    DOI: 10.3143/geriatrics.46.179

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Books

  • Onco-cardiology

    Shintaro Minegishi( Role: Contributor)

    2025.1 

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  • Onco-Hypertension

    Shintaro Minegieshi( Role: Contributor)

    2025.1 

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  • Heart failure

    Shintaro Minegishi( Role: Contributor)

    2025.1 

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  • Malignant Pericardial Effusion, Pericarditis, Cardiac Tamponade

    Shintaro Minegieshi, Masatoshi Narikawa( Role: Contributor)

    2025.1 

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  • thromboembolism

    Shintaro Minegishi( Role: Contributor)

    2025.1 

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  • Onco-hypertension

    Shintaro Minegishi, Akira Nishiyama( Role: ContributorNippon Rinsho Vol82. Suppl 2, 2024)

    Nippon Rinsho  2024.4 

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    Total pages:580   Responsible for pages:527-534   Language:Japanese   Book type:Textbook, survey, introduction

    XI. Development of new scientific fields Onco-hypertension

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  • The relationship between hypertension and cancer:New concept of an emerging specialty "Onco-Hypertension" and future perspectives.

    Shintaro Minegishi, Akira Nishiyama( Role: Contributor)

    KAGAKU-HYORONSHA  2023.2 

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  • Na-MRI

    ( Role: Contributor)

    2020.2 

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  • 元素シグナル ナトリウム(TonEBP)

    峯岸慎太郎、峯岸薫、北田研人( Role: Contributor腎臓内科 = Nephrology 11(2) 184-190)

    科学評論社  2020.2 

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    Total pages:7   Responsible for pages:184   Language:Japanese  

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  • 食塩と体液バランスの最新知見

    峯岸慎太郎, 北田研人( Role: Contributor循環器内科 第85巻第1号 特集 腎臓・高血圧診療・研究のアップデート)

    科学評論社  2019.1 

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    Responsible for pages:130-135   Language:Japanese   Book type:General book, introductory book for general audience

    最近の「食塩」に関する研究によって、既存の常識とは異なるコンセプトが次々と明らかになりつつある。一方、食塩と血圧の関連性は 、これまで腎機能を中心に研究されてきた。今後は、本稿で紹介した「食塩」に関する最新のコンセプトをもとに、腎臓のみならず、皮膚、肝臓 、 筋肉の機能も考慮した研究が展開さ れ、「なぜ食塩の過剰摂取は悪なのか」、「なぜ減塩が良いのか」、「なぜ食塩感受性高血圧症が発症するのか」、その 全容が解明されることを期待したい。

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  • Calcium antagonist (dihydropyridine and non-dihydropyridine)

    Shintaro Minegishi, Kiwamu Iwata, Kouichi Tamura( Role: ContributorHeart View Vol.27 No.12, 2023)

    2023.11 

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  • 【動脈・静脈の疾患(下)-最新の診断・治療動向-】動脈・静脈の疾患(臓器別) 腎臓 腎動脈狭窄

    峯岸 慎太郎, 石上 友章, 石川 利之, 田村 功一( Role: Contributor日本臨床 75(増刊5 動脈・静脈の疾患(下)) 869-873)

    (株)日本臨床社  2017.7 

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  • 【主治医として診る高血圧診療】臓器障害の評価 心血管系 心電図,心エコー

    峯岸 慎太郎, 石上 友章( Role: ContributorMedicina 53(11) 1756-1759)

    (株)医学書院  2016.10 

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  • 何が正解?循環器治療 EBMで検証 早朝高血圧の治療

    峯岸 慎太郎, 牛尾 比早子, 石上 友章, 内野 和顕, 梅村 敏( Role: Contributor治療 92(6) 1733-1738)

    (株)南山堂  2010.6 

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  • 【ナースがこれだけは知っておきたい! 事例に学ぶ循環器の薬剤】高血圧の患者さんに用いる薬剤 第一選択薬をどのような観点から選ぶか?

    峯岸 慎太郎, 牛尾, 比早子, 石上, 友章, 内野, 和顕, 梅村 敏( Role: Contributorハートナーシング 23(1) 36-43)

    (株)メディカ出版  2010.1 

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MISC

  • Onco-Hypertensionにおけるエビデンス構築の試み Systematic Reviewの結果に基づいたStatement

    峯岸 慎太郎

    日本高血圧学会総会プログラム・抄録集   46回   326 - 326   2024.10

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  • デジタル技術は血圧を低下させるか? 尿ナトリウム/カリウム比および食事・尿ナトリウム濃度の測定デバイスを用いた介入は血圧を低下させるか システマティックレビューとメタ分析

    久松 隆史, 上田 浩平, 荒川 仁香, 峯岸 慎太郎, 岡見 雪子, 絹田 皆子, 近藤 慶子, 陣内 裕成, 石原 真穂, 阿部 真紀子, 崎間 敦, 有馬 久富

    日本高血圧学会総会プログラム・抄録集   46回   634 - 634   2024.10

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  • 非侵襲的血管指標Arterial Pressure volume Indexと久山町スコアによる絶対リスク値の関連

    本望 寛人, 川島 歩果, 上野 ひかる, 木野 旅人, 中島 理恵, 内田 浩太郎, 菅原 拓哉, 峯岸 慎太郎, 陳 彬, 荒川 健太郎, 日比 潔, 石上 友章

    日本高血圧学会総会プログラム・抄録集   46回   563 - 563   2024.10

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  • 非侵襲的血管指標(AVI・API・Aortic Aix)から導出した、血管年齢(Bruno)の性能についての検討(第二報)

    川島 歩果, 上野 ひかる, 本望 寛人, 木野 旅人, 中島 理恵, 内田 浩太郎, 菅原 拓哉, 峯岸 慎太郎, 陳 琳, 荒川 健太郎, 日比 潔, 石上 友章

    日本高血圧学会総会プログラム・抄録集   46回   552 - 552   2024.10

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  • 非侵襲的血管指標AVI・API高値群の,中心動脈脈波指標についての検討

    本望 寛人, 上野 ひかる, 川島 歩果, 木野 旅人, 中島 理恵, 内田 浩太郎, 菅原 拓哉, 峯岸 慎太郎, 陳 琳, 荒川 健太郎, 日比 潔, 石上 友章

    日本高血圧学会総会プログラム・抄録集   46回   562 - 562   2024.10

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  • 小児がんサバイバーにおける高血圧の発症頻度 系統的レビューとメタアナリシス

    浅井 真成, 所 卓見, 峯岸 慎太郎, 堀米 旭, 服部 京子, 石井 怜, 花島 陽平, 岡崎 善則, 小村 直弘, 石上 友章, 日比 潔, 矢野 裕一朗, 西山 成

    日本高血圧学会総会プログラム・抄録集   46回   432 - 432   2024.10

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  • 非侵襲的血管指標(AVI・API・Aortic Aix)から導出した、血管年齢(Bruno)の性能についての検討(第一報)

    上野 ひかる, 川島 歩果, 本望 寛人, 木野 旅人, 中島 理恵, 内田 浩太郎, 菅原 拓哉, 峯岸 慎太郎, 陳 琳, 荒川 健太郎, 日比 潔, 石上 友章

    日本高血圧学会総会プログラム・抄録集   46回   551 - 551   2024.10

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  • Onco-Hypertensionにおけるエビデンス構築の試み 多施設共同での臨床研究の試み

    森本 聡, 北岡 かおり, 峯岸 慎太郎, 向井 幹夫, 矢野 裕一朗, 西山 成

    日本高血圧学会総会プログラム・抄録集   46回   327 - 327   2024.10

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  • 成人の高血圧患者における降圧治療は固形がん発症のリスクを改善するか? 系統的レビューとメタアナリシス

    堀米 旭, 服部 京子, 峯岸 慎太郎, 石井 怜, 浅井 真成, 所 卓見, 花島 陽平, 岡崎 善則, 小村 直弘, 石上 友章, 日比 潔, 矢野 裕一朗, 西山 成

    日本高血圧学会総会プログラム・抄録集   46回   431 - 431   2024.10

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  • Onco-Hypertensionにおけるエビデンス構築の試み CQの設定とSystematic Reviewによるエビデンス構築

    浅井 真成, 所 卓見, 堀米 旭, 服部 京子, 石井 怜, 花島 陽平, 岡崎 善則, 小村 直弘, 峯岸 慎太郎, 石上 友章, 日比 潔

    日本高血圧学会総会プログラム・抄録集   46回   326 - 326   2024.10

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  • 腫瘍循環器としての肺高血圧症の検討

    鈴木徹, 岩橋徳明, 相澤広太郎, 峯岸慎太郎, 小村直弘, 川浦範之, 小西正紹, 石上友章, 菅野晃靖, 日比潔, 日比潔

    日本肺高血圧・肺循環学会学術集会抄録集(Web)   9th (CD-ROM)   124 - 124   2024.8

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  • 健康・病態におけるカリウム/ナトリウムバランスの重要性を再考する カリウム喪失と体液保持機構に着目した食塩感受性高血圧症 MR機能の再考

    峯岸 慎太郎

    日本腎臓学会誌   66 ( 4 )   543 - 543   2024.6

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  • 健康・病態におけるカリウム/ナトリウムバランスの重要性を再考する カリウム喪失と体液保持機構に着目した食塩感受性高血圧症 MR機能の再考

    峯岸 慎太郎

    日本腎臓学会誌   66 ( 4 )   543 - 543   2024.6

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  • Onco-hypertension: the relationship between hypertension and cancer

    峯岸慎太郎, 西山成

    日本臨床   82 ( 増刊2 腫瘍循環器学 )   527 - 534   2024.4

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  • Legs Elevation Method may be Useful for Diagnosis of Exclusion for Exercised Pulmonary Hypertension

    鈴木徹, 相澤広太郎, 峯岸慎太郎, 小村直弘, 川浦範之, 小西正紹, 岩橋徳明, 石上友章, 菅野晃靖, 日比潔, 日比潔

    日本循環器学会学術集会(Web)   88th   PJ062 - 3   2024.3

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  • Legs Elevation Method may be Useful for Diagnosis of Exclusion for Exercised Pulmonary Hypertension

    鈴木徹, 相澤広太郎, 峯岸慎太郎, 小村直弘, 川浦範之, 小西正紹, 岩橋徳明, 石上友章, 菅野晃靖, 日比潔, 日比潔

    日本循環器学会学術集会(Web)   88th   PJ062 - 3   2024.3

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  • 成人のがんサバイバーにおける高血圧と固形がん再発リスク:系統的レビューとメタアナリシス

    岡崎善則, 小村直弘, 峯岸慎太郎, 堀米旭, 石井怜, 所卓見, 服部京子, 浅井真成, 花島陽平, 石上友章, 日比潔, 日比潔, 矢野裕一朗, 西山成

    日本腫瘍循環器学会学術集会抄録集(Web)   7th   2024

  • がん治療におけるレニン・アンジオテンシン系阻害薬の役割

    石井怜, 花島陽平, 峯岸慎太郎, 堀米旭, 服部京子, 所卓見, 浅井真成, 岡崎善則, 小村直弘, 石上友章, 日比潔, 日比潔, 矢野裕一朗, 西山成

    日本腫瘍循環器学会学術集会抄録集(Web)   7th   2024

  • カリウム喪失と体液保持機構に着目した食塩感受性高血圧症:MR機能の再考

    峯岸慎太郎

    日本腎臓学会誌(Web)   66 ( 4 )   2024

  • 循環器薬の特徴について識る 1 Ca拮抗薬(ジヒドロピリジン系・非ジヒドロピリジン系)

    峯岸慎太郎, 岩田究, 岩田究, 田村功一

    Heart View   27 ( 12 )   6 - 11   2023.11

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  • 先天性横隔膜ヘルニア術後の若年女性に発症した肺高血圧症の1例

    相澤広太郎, 日比潔, 石上友章, 岩橋徳明, 小西正昭, 細田順也, 川浦範之, 小村直弘, 峯岸慎太郎, 鈴木徹

    日本内科学会関東支部関東地方会   689th   30 - 30   2023.9

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  • 先天性横隔膜ヘルニア術後の若年女性に発症した肺高血圧症の1例

    相澤 広太郎, 日比 潔, 石上 友章, 岩橋 徳明, 小西 正昭, 細田 順也, 川浦 範之, 小村 直弘, 峯岸 慎太郎, 鈴木 徹

    日本内科学会関東地方会   689回   30 - 30   2023.9

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  • Feasibility of new vascular index, API, showed complexity of coronary atherosclerosis

    多田直輝, 垂水翔, 内田浩太郎, 菅原拓哉, 陳琳, 川浦範之, 峯岸慎太郎, 木野旅人, 荒川健太郎, 石上友章, 日比潔

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   45th   427 - 427   2023.9

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  • Management of hypertension in patients with cancer

    峯岸慎太郎

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   45th   159 - 159   2023.9

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  • The relationship between hypertension and cancer: New concept of an emerging specialty ”Onco-Hypertension” and future perspectives. Invited

    峯岸慎太郎, 西山成

    循環器内科   93 ( 2 )   161 - 168   2023.2

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  • 担癌患者における免疫チェックポイント阻害薬と高血圧リスクとの関連性

    金口翔, 峯岸慎太郎, 堀田信之, HO Namkoong, ALEXANDROS Briasoulis, 石上友章, 田村功一, 西山成, 矢野裕一朗

    日本心血管内分泌代謝学会学術総会プログラム及び抄録集   27th (CD-ROM) ( 5 )   1601 - 1601   2023

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  • 5/6腎摘ラットにおける腎臓からの体液喪失は、腎臓以外の体液保持機構を活性化し、筋肉量減少および高血圧の一因となる

    森澤 紀彦, Kovarik Johannes J., Wild Johannes, Adriana Marton, 峯岸 薫, 峯岸 慎太郎, Daub Steffen, Sands Jeff M., Kovalik Jean-Paul, Rauh Manfred, Luft Friedrich, 西山 成, 中野 大介, 北田 研人, Titze Jens

    日本高血圧学会総会プログラム・抄録集   43回   220 - 220   2021.10

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  • Deoxycorticosterone acetate (DOCA) leads to elevated blood pressure due to loss of body water

    峯岸慎太郎, 峯岸慎太郎, 北田研人, 森澤紀彦, 森澤紀彦, 小豆島健護, 西山成, 石上友章, 田村功一

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   43rd   222 - 222   2021.10

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  • 本態性高血圧症の成因-水喪失と体液保持機構の観点から

    峯岸慎太郎, 峯岸慎太郎

    高血圧関連疾患モデル学会学術総会抄録集   57th (CD-ROM) ( 5 )   1449 - 1449   2021

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  • 酢酸デオキシコルチコステロン(DOCA)は体液喪失を介して血圧を上昇させる

    峯岸慎太郎, 北田研人, 森澤紀彦, 小豆島健護, 西山成, 石上友章, 田村功一

    高血圧関連疾患モデル学会学術総会抄録集   57th (CD-ROM) ( 5 )   1471 - 1471   2021

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  • Na-MRI Invited

    11 ( 2 )   168 - 173   2020.2

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  • Sodium (TonEBP) Invited

    11 ( 2 )   184 - 190   2020.2

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  • カフ・オシロメトリック法を応用した脈波計(SphygmoCor Xcel, A&D Medical, Japan)による、心機能評価の可能性についての検討

    大塚 日尚子, 下田 萌斗, 寺中 紗絵, 石上 友章, 木野 旅人, 安部 開人, 峯岸 慎太郎, 杉山 美智子, 菅原 拓哉, 小豆島 健吾, 涌井 広道, 田村 功一

    日本高血圧学会総会プログラム・抄録集   42回   371 - 371   2019.10

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  • 腎血行動態指標(RI, resistive index)と、心機能・脈波指標との関係の検討

    下田 萌斗, 大塚 日尚子, 寺中 紗絵, 石上 友章, 木野 旅人, 菅原 拓哉, 安部 開人, 峯岸 慎太郎, 杉山 美智子, 涌井 広道, 小豆島 健吾, 田村 功一

    日本高血圧学会総会プログラム・抄録集   42回   267 - 267   2019.10

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  • カフ・オシロメトリック法を応用した脈波計(SphygmoCor Xcel, A&D Medical, Japan)による、心機能評価の可能性についての検討

    大塚 日尚子, 下田 萌斗, 寺中 紗絵, 石上 友章, 木野 旅人, 安部 開人, 峯岸 慎太郎, 杉山 美智子, 菅原 拓哉, 小豆島 健吾, 涌井 広道, 田村 功一

    日本高血圧学会総会プログラム・抄録集   42回   371 - 371   2019.10

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  • 腎血行動態指標(RI, resistive index)と、心機能・脈波指標との関係の検討

    下田 萌斗, 大塚 日尚子, 寺中 紗絵, 石上 友章, 木野 旅人, 菅原 拓哉, 安部 開人, 峯岸 慎太郎, 杉山 美智子, 涌井 広道, 小豆島 健吾, 田村 功一

    日本高血圧学会総会プログラム・抄録集   42回   267 - 267   2019.10

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  • Evaluation of Measurement by Echography using Myocardial Infracted Mouse:Trail by nursing student

    荻野 千菜美, 千葉 由美, 峯岸 慎太郎, 石上 友章

    横浜看護学雑誌 = Yokohama Journal of Nursing   12 ( 1 )   61 - 69   2019.3

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  • 看護学生による心筋梗塞モデルマウスを用いた超音波検査法の手技に関する評価

    荻野 千菜美, 千葉 由美, 峯岸 慎太郎, 石上 友章

    横浜看護学雑誌   12 ( 1 )   61 - 69   2019.3

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  • 食塩と体液バランスの最新知見 Invited

    峯岸慎太郎, 北田研人

    循環器内科   85 ( 1 )   130 - 135   2019.1

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  • 心臓手術後の嚥下障害患者についての臨床 文献的考察(Practice for dysphagic patients following cardiac operation: Literature review)

    千葉 由美, 大橋 伸英, 渡邊 裕, 本橋 佳子, 戸原 玄, 野原 幹司, 中山 渕利, 峯岸 慎太郎

    日本摂食・嚥下リハビリテーション学会雑誌   22 ( 3 )   S391 - S391   2018.12

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  • 慢性腎臓病患者における冠動脈疾患二次予防のための至適薬物療法(OMT)の検討

    木野旅人, 石上友章, 寺中紗絵, 土肥宏志, 陳琳, 中島理恵, 安部開人, 峯岸慎太郎, 荒川健太郎, 田村功一

    日本心血管内分泌代謝学会学術総会プログラム及び抄録集   22nd ( 4 )   120 - 1570   2018.12

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  • 慢性腎臓病患者における冠動脈疾患二次予防のための至適薬物療法(OMT)の検討

    木野 旅人, 石上 友章, 寺中 紗絵, 土肥 宏志, 陳 琳, 中島 理恵, 安部 開人, 峯岸 慎太郎, 荒川 健太郎, 田村 功一

    日本内分泌学会雑誌   94 ( 4 )   1570 - 1570   2018.12

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  • カフ・オシロメトリック法による中心血圧の測定による心機能評価の可能性

    寺中紗絵, 石上友章, 土肥宏志, 木野旅人, 峯岸慎太郎, 中島理恵, 荒川健太郎, 杉山美智子, 石川利之, 田村功一

    日本高血圧学会総会プログラム・抄録集   41回   PC01 - 03   2018.9

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  • カフ・オシロメトリック法による中心血圧の測定による心機能評価の可能性

    寺中 紗絵, 石上 友章, 土肥 宏志, 木野 旅人, 峯岸 慎太郎, 中島 理恵, 荒川 健太郎, 杉山 美智子, 石川 利之, 田村 功一

    日本高血圧学会総会プログラム・抄録集   41回   PC01 - 03   2018.9

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  • 心不全患者において位相contrast cine MRIによって評価した冠血流予備能(Coronary Flow Reserve Assessed by Phase-Contrast Cine Magnetic Resonance Imaging in Heart Failure Patients)

    加藤 真吾, 齋藤 央, 朝比奈 直揮, 飯沼 直紀, 峯岸 慎太郎, 上村 大輔, 仲地 達哉, 福井 和樹, 岩澤 多恵, 小菅 雅美, 木村 一雄, 田村 功一

    日本心臓病学会学術集会抄録   66回   YIA - 2   2018.9

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  • カフ・オシロメトリック法による血圧・血管指標の測定値に与える,繰り返しカフ圧負荷の影響についての検討

    織井隆介, 石上友章, 土肥宏志, 寺中紗絵, 木野旅人, 中島理恵, 杉山美智子, 峯岸慎太郎, 安部開人, 田村功一

    日本高血圧学会総会プログラム・抄録集   41回   OC09 - 01   2018.9

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  • カフ・オシロメトリック法による血圧・血管指標の測定値に与える、繰り返しカフ圧負荷の影響についての検討

    織井 隆介, 石上 友章, 土肥 宏志, 寺中 紗絵, 木野 旅人, 中島 理恵, 杉山 美智子, 峯岸 慎太郎, 安部 開人, 田村 功一

    日本高血圧学会総会プログラム・抄録集   41回   OC09 - 01   2018.9

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  • IMPACT OF MYOCARDIAL EXTRACELLULAR VOLUME ASSESSED BY CARDIAC MAGNETIC RESONANCE T1 MAPPING ON SYSTOLIC AND DIASTOLIC FUNCTION OF THE HEART Reviewed

    Saito Naka, Kato Shingo, Asahina Naoki, Iinuma Naoki, Minegishi Shintaro, Kamimura Daisuke, Nakachi Tatsuya, Fukui Kazuki, Kosuge Masami, Kimura Kazuo, Tamura Kouichi

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   71 ( 11 )   1518   2018.3

  • マウス腎尿細管における(プロ)レニン受容体の機能解析

    松沼 まり, 木野 旅人, 寺中 紗絵, 土肥 宏志, 中島 理恵, 峯岸 慎太郎, 杉山 美智子, 荒川 健太郎, 石上 友章, 田村 功一

    日本内分泌学会雑誌   93 ( 4 )   1390 - 1390   2017.12

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  • マウス腎尿細管における(プロ)レニン受容体の機能解析

    松沼まり, 木野旅人, 寺中紗絵, 土肥宏志, 中島理恵, 峯岸慎太郎, 杉山美智子, 荒川健太郎, 石上友章, 田村功一

    日本心血管内分泌代謝学会学術総会プログラム及び抄録集   21st ( 4 )   1390 - 1390   2017.12

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  • Prognostic Significance of Magnetic Resonance Imaging Derived Coronary Flow Reserve for Heart Failure Patients Reviewed

    Kato Shingo, Asahina Naoki, Iinuma Naoki, Kusakawa Yuka, Minegishi Shintaro, Kamimura Daisuke, Nakachi Tatsuya, Fukui Kazuki, Kosuge Masami, Kimura Kazuo, Tamura Kouichi

    CIRCULATION   136   2017.11

  • 冠動脈疾患二次予防のための日本における至適薬物療法(OMT)の検討

    木野旅人, 石上友章, 寺中紗絵, 土肥宏志, 陳琳, 中島理恵, 安部開人, 峯岸慎太郎, 杉山美智子, 荒川健太郎, 菅野晃靖, 石川利之, 田村功一

    日本高血圧学会総会プログラム・抄録集   40回   381 - 381   2017.10

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  • 労作時息切れを契機に発見された肝肺症候群の1例

    朝比奈直揮, 飯沼直紀, 加藤真吾, 峯岸慎太郎, 上村大輔, 仲地達哉, 福井和樹

    日本内科学会関東支部関東地方会   635回   42 - 42   2017.9

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  • 労作時息切れを契機に発見された肝肺症候群の1例

    朝比奈 直揮, 飯沼 直紀, 加藤 真吾, 峯岸 慎太郎, 上村 大輔, 仲地 達哉, 福井 和樹

    日本内科学会関東地方会   635回   42 - 42   2017.9

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  • 【動脈・静脈の疾患(下)-最新の診断・治療動向-】 動脈・静脈の疾患(臓器別) 腎臓 腎動脈狭窄 Invited

    峯岸 慎太郎, 石上 友章, 石川 利之, 田村 功一

    日本臨床   75 ( 増刊5 動脈・静脈の疾患(下) )   869 - 873   2017.7

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  • 新しい血管指数のAPI/AVIと冠動脈アテローム硬化病変との相関関係(Correlation between New Vacular Index, API/AVI and Coronary Atherosclerotic Lesion)

    Doi Hiroshi, Nakashima Rie, Kino Tabito, Minegishi Shintaro, Chen Lin, Sugano Teruyasu, Ishigami Tomoaki

    日本循環器学会学術集会抄録集   81回   PE - 679   2017.3

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  • 動脈硬化症における炎症の永続性をもたらす,自己抗体を介する自己免疫基盤の解明と診療への応用

    石上友章, 陳琳, 中島理恵, 木野旅人, 峯岸慎太郎, 土肥正志, 田村功一

    生物試料分析   40 ( 1 )   5 - 5   2017.1

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  • Nedd4-2 C2ノックアウトマウスを用いた心房細動の誘発に対する影響の検討

    川村 飛翔, 峯岸 慎太郎, 陳 琳, 中島 理恵, 木野 旅人, 土肥 宏志, Prajapati Rajesh, 藤田 孝之, 石川 義弘, 石上 友章

    日本内分泌学会雑誌   92 ( 3 )   904 - 904   2017.1

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  • Naチャネル調節因子Nedd4‐2の心臓電気生理学的表現型に与える影響の解析

    川村飛翔, 峯岸慎太郎, 中島理恵, 土肥宏志, 陳琳, 木野旅人, 石川義弘, 藤田孝之, PLAJAPATI Rajesh, 石上友章

    日本循環器学会関東甲信越地方会(Web)   243rd   KANTOKOSHIN'ETSU243,89 (WEB ONLY)   2017

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  • 【主治医として診る高血圧診療】 臓器障害の評価 心血管系 心電図,心エコー Invited

    峯岸 慎太郎, 石上 友章

    Medicina   53 ( 11 )   1756 - 1759   2016.10

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  • 不死化ヒト近位尿細管上皮細胞の作製と,その特性評価について

    中島理恵, 安部開人, 陳琳, 峯岸慎太郎, 木野旅人, 土肥宏志, 杉山美智子, 梅村敏, 石上友章

    日本高血圧学会総会プログラム・抄録集   39th   328 - 328   2016.9

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  • Nedd4-2C2KOマウスにおけるエプレレノン抵抗性食塩感受性高血圧の病態について

    木野 旅人, 村田 紡, 峯岸 慎太郎, 中島 理恵, 陳 琳, 土肥 宏志, 杉山 美智子, 梅村 敏, 石上 友章

    日本高血圧学会総会プログラム・抄録集   39回   336 - 336   2016.9

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  • Nedd4-2C2KOマウスにおけるエプレレノン抵抗性食塩感受性高血圧の病態について

    木野 旅人, 村田 紡, 峯岸 慎太郎, 中島 理恵, 陳 琳, 土肥 宏志, 杉山 美智子, 梅村 敏, 石上 友章

    日本高血圧学会総会プログラム・抄録集   39回   336 - 336   2016.9

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  • 不死化ヒト近位尿細管上皮細胞の作製と、その特性評価について

    中島 理恵, 安部 開人, 陳 琳, 峯岸 慎太郎, 木野 旅人, 土肥 宏志, 杉山 美智子, 梅村 敏, 石上 友章

    日本高血圧学会総会プログラム・抄録集   39回   328 - 328   2016.9

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  • 高血圧等の生活習慣病発症におけるゲノムとエピゲノム Hypothesis Driven Approachによる、食塩感受性・高血圧症の成因としての、ENaC-Nedd4L/Nedd4-2系の役割の検討(Implications of Hypothesis Driven Approaches for Molecular Basis of Salt Sensitivity and Hypertension-Analyses Focusing on tubular ENaC-Nedd4L/Nedd4-2 Systems)

    石上 友章, 峯岸 慎太郎, 新城 名保美, 中島 理恵, 陳 琳, 木野 旅人, 土肥 宏志, 杉山 美智子, 藤田 恵美, 谷津 圭介, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   39回   257 - 257   2016.9

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  • 高血圧等の生活習慣病発症におけるゲノムとエピゲノム Hypothesis Driven Approachによる、食塩感受性・高血圧症の成因としての、ENaC-Nedd4L/Nedd4-2系の役割の検討(Implications of Hypothesis Driven Approaches for Molecular Basis of Salt Sensitivity and Hypertension-Analyses Focusing on tubular ENaC-Nedd4L/Nedd4-2 Sys

    石上 友章, 峯岸 慎太郎, 新城 名保美, 中島 理恵, 陳 琳, 木野 旅人, 土肥 宏志, 杉山 美智子, 藤田 恵美, 谷津 圭介, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   39回   257 - 257   2016.9

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  • 心筋活動電位制御に対するSCN5A‐Ncdd4‐2系の役割についての検討

    峯岸慎太郎, 木野旅人, 中島理恵, 陳琳, 土肥宏志, 川村飛翔, 杉山美智子, 梅村敏, 梅村敏, 石上友章

    日本高血圧学会総会プログラム・抄録集   39回   344 - 344   2016.9

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  • 心筋活動電位制御に対するSCN5A-Nedd4-2系の役割についての検討

    峯岸 慎太郎, 木野 旅人, 中島 理恵, 陳 琳, 土肥 宏志, 川村 飛翔, 杉山 美智子, 梅村 敏, 石上 友章

    日本高血圧学会総会プログラム・抄録集   39回   344 - 344   2016.9

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  • 出産後にリステリア髄膜炎をきたしたが母児ともに救命しえた抗リン脂質抗体症候群合併SLEの一例

    峯岸 慎太郎, 杉山 裕美子, 土田 奈緒美, 神山 玲光, 峯岸 薫, 浜 真麻, 吉見 吉見, 桐野 洋平, 上田 敦久, 森村 尚登

    日本集中治療医学会雑誌   23 ( Suppl. )   758 - 758   2016.1

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  • 91歳女性の左冠動脈主幹部完全閉塞急性心筋梗塞,心原性ショックに対し冠動脈形成術を行い自宅退院した1例

    辻川雄, 神原かおり, 福岡雅浩, 降旗修太, 河南智子, 峯岸慎太郎, 持田泰行

    日本老年医学会雑誌   52 ( 4 )   435 - 435   2015.10

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  • 末梢動脈疾患患者の予後予測因子としての抗IL-5抗体の有用性の検討

    安部 開人, 石上 友章, 菅野 晃靖, 松本 克己, 矢野 英人, 細田 順也, 清國 雅義, 土肥 宏志, 中島 理恵, 木野 旅人, 峯岸 慎太郎, 澤崎 達也, 石川 利之, 木村 一雄, 梅村 敏

    日本心臓病学会学術集会抄録   63rd   870 - 870   2015.9

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  • Successful cardiovascular risk prediction by new non-invasive vascular index using AVE-1500 for the subjects with various clinical background

    NAKASHIMA Rie, ISHIGAMI Tomoaki, DOI Hiroshi, KINO Tabito, CHEN Rin, MINEGISHI Shintaro, UMEMURA Satoshi

    日本血管生物医学会学術集会プログラム・抄録集   23rd   169   2015

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  • PCI後に発症した脳梗塞に対して血栓溶解療法を施行した2時間後にステント血栓症を発症した1例

    降旗 修太, 峯岸 慎太郎, 辻川 雄, 福岡 雅浩, 神原 かおり, 持田 泰行

    日本内科学会関東地方会   610回   45 - 45   2014.11

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  • 新規レニンの発見と,尿細管における発現,制御についての検討

    木野旅人, 石上友章, 陳琳, 佐々木理恵, 安部開人, 峯岸慎太郎, 新城名保美, 梅村敏

    日本内分泌学会雑誌   90 ( 2 )   754   2014.9

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  • 新規レニンの発見と、尿細管における発現、制御についての検討

    木野 旅人, 石上 友章, 陳 琳, 佐々木 理恵, 安部 開人, 峯岸 慎太郎, 新城 名保美, 梅村 敏

    日本内分泌学会雑誌   90 ( 2 )   754 - 754   2014.9

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  • アルドステロン感受性遠位ネフロンにおけるENaC活性化と高血圧発症機序について

    石阪 麻莉, 石上 友章, 佐々木 理恵, 陳 琳, 木野 旅人, 安部 開人, 峯岸 慎太郎

    日本内分泌学会雑誌   90 ( 2 )   755 - 755   2014.9

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  • RA系降圧薬を単独投与した場合と,併用した場合の腎障害の比較について

    光楽泰信, 石上友章, 佐々木理恵, 陳琳, 安部開人, 峯岸慎太郎, 梅村敏

    日本内分泌学会雑誌   90 ( 2 )   756 - 756   2014.9

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  • 早朝高血圧患者におけるαβ遮断薬とα遮断薬の夕食後服用による降圧効果の比較

    峯岸 慎太郎, 石上 友章, 持田 泰行, 梅村 敏

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   3回   146 - 146   2014.5

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  • 腎および肺疾患の標的としての上皮イオンチャネル研究の最前線 Nedd4Lおよび尿細管レニン-アンジオテンシン系を介したENaC発現機能制御

    石上 友章, 梅村 将就, 新城 名保美, 峯岸 慎太郎, 山名 比早子

    日本薬学会年会要旨集   134年会 ( 1 )   257 - 257   2014.3

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  • 肺癌に対するシスプラチン(CDDP)併用化学療法における経口補液を用いた短時間輸液療法の多施設試験

    宮永晃彦, 久保田馨, 峯岸裕司, 武内進, 中道真仁, 弦間昭彦, 内海裕文, 角南久仁子, 水柿秀紀, 神田慎太郎, 堀之内秀仁, 藤原豊, 軒原浩, 山本昇, 田村友秀, 栗本太嗣, 須藤淳子, 山根由紀, 都築早美, 酒井洋

    日本肺癌学会学術集会号   55th   2014

  • 食塩感受性高血圧の成因における尿細管レニンアンジオテンシン系の役割についての検討

    峯岸 慎太郎, 山名 比早子, 石上 友章, 新城 名保美, 梅村 将就, 内野 和顕, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   35回   517 - 517   2012.9

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  • Blood pressure management for the subject with diabetes mellitus

    石上 友章, 峯岸 慎太郎, 安部 開人

    ホルモンと臨床   60 ( 5 )   403 - 408   2012.5

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  • 【日本人の糖尿病と欧米人の糖尿病】 糖尿病の治療法に関する相違 血圧管理

    石上 友章, 峯岸 慎太郎, 安部 開人, 佐々木 理恵, 陳 琳, 梅村 敏

    ホルモンと臨床   60 ( 5 )   403 - 408   2012.5

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  • 多機能家庭血圧計(HEM5041)を用いて評価したカンデサルタン/サイアザイド合剤の有効性

    山名 比早子, 石上 友章, 峯岸 慎太郎, 梅村 敏

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   1回   149 - 149   2012.4

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  • Nedd4L C2ドメインノックアウトマウスの作成と表現型の解析

    峯岸 慎太郎, 石上 友章, 山名 比早子, 新城 名保美, 梅村 将就, 内野 和顕, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   34回   401 - 401   2011.10

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  • 新規家庭血圧計を用いた推定基底血圧の評価についての検討

    大島 聡人, 石上 友章, 峯岸 慎太郎, 山名 比早子, 新城 名保美, 梅村 将就, 内野 和顕, 梅村 敏, 藤川 哲也

    日本高血圧学会総会プログラム・抄録集   34回   599 - 599   2011.10

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  • 尿細管イオントランスポーターの翻訳後修飾に着目した高血圧症の食塩感受性の分子機序の検討

    石上 友章, 峯岸 慎太郎, 山名 比早子, 内野 和顕, 戸谷 義幸, 梅村 将就, 新城 名保美, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   34回   374 - 374   2011.10

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  • Examinations for the Effects on Renal Renin-Angiotensin Systems by Two Different Diuretics, Tolvaptan and Furosemide

    Tabito Kino, Ayaka Nishikawa, Reo Matsumura, Tomoaki Ishigami, Shintaro Minegishi, Hisako Yamana, Kaito Abe, Kazuaki Uchino, Satoshi Umemura

    JOURNAL OF CARDIAC FAILURE   17 ( 9 )   S154 - S155   2011.9

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    DOI: 10.1016/j.cardfail.2011.06.508

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  • 食塩感受性高血圧モデルにおける臓器障害に対するRA系降圧薬の効果の検討

    峯岸 慎太郎, 石上 友章, 牛尾 比早子, 新城 名保美, 田村 功一, 出島 徹, 安部 開人, 内野 和顕, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   33回   254 - 254   2010.10

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  • 意識障害を主訴に来院された高齢者のStanford A型急性大動脈解離の2例

    重政 朝彦, 小林 俊一, 糟谷 深, 峯岸 慎太郎

    日本老年医学会雑誌   47 ( 4 )   351 - 352   2010.7

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  • 当院における慢性心房細動患者に対する心臓リハビリテーションの検討

    糟谷 深, 重政 朝彦, 三橋 孝之, 郷原 正臣, 小林 俊一, 峯岸 慎太郎, 高橋 祐己, 笹渡 幸江, 上村 さと美

    心臓リハビリテーション   15 ( 2 )   323 - 326   2010.6

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  • 何が正解?循環器治療 EBMで検証 早朝高血圧の治療 Invited

    峯岸 慎太郎, 牛尾 比早子, 石上 友章, 内野 和顕, 梅村 敏

    治療   92 ( 6 )   1733 - 1738   2010.6

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  • 何が正解?循環器治療 EBMで検証 安定型冠動脈疾患の最適な治療はPCIか、CABGか、OMTか?

    石上 友章, 内野 和顕, 菅野 晃靖, 高村 武, 重永 豊一郎, 安部 開人, 峯岸 慎太郎, 一原 直昭, 山川 陽平, 松本 克己, 松下 浩平, 細田 順也, 石川 利之, 木村 一雄, 梅村 敏

    治療   92 ( 2 )   364 - 376   2010.2

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  • 【ナースがこれだけは知っておきたい! 事例に学ぶ循環器の薬剤】高血圧の患者さんに用いる薬剤 第一選択薬をどのような観点から選ぶか? Invited

    峯岸 慎太郎, 牛尾 比早子, 石上 友章, 内野 和顕, 梅村 敏

    ハートナーシング   23 ( 1 )   36 - 43   2010.1

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  • 【糖尿病の血圧管理】ACE阻害薬・ARBの降圧を超えた臓器保護はあるのか

    石上 友章, 牛尾 比早子, 峯岸 慎太郎, 新城 名保美, 梅村 敏

    Diabetes Frontier   20 ( 6 )   696 - 702   2009.12

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  • 食塩感受性高血圧モデルマウスのterminal nephronにおけるナトリウム再吸収機構の検討

    牛尾 比早子, 石上 友章, 新城 名保美, 峯岸 慎太郎, 田村 功一, 戸谷 義幸, 内野 和顕, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   32回   237 - 237   2009.10

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  • Potential utility of ambulatory blood pressure monitoring in patients with congestive heart failure

    Takeshi Takamura, Tomoaki Ishigami, Kazuaki Uchino, Naomi Araki, Hisako Ushio, Shintaro Minegishi, Teruyasu Sugano, Kohei Matsushita, Katsumi Matsumoto, Yohei Yamakawa, Toshiyuki Ishikawa, Kazuo Kimura, Satoshi Umemura

    Therapeutic Research   30   1167 - 1172   2009.9

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  • 当院で経験した卵巣明細胞腺癌に肺塞栓症を合併した2症例

    重政 朝彦, 小林 俊一, 糟谷 深, 峯岸 慎太郎, 唐澤 英偉

    日本画像医学雑誌   27 ( 2 )   121 - 121   2009.2

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  • Swedish Trial in Old Patients with Hypertension

    築山 久一郎, 小林 俊一, 峯岸 慎太郎

    Japanese journal of clinical medicine   66 ( 増刊8 大規模臨床試験 )   96 - 100   2008.10

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  • 心不全を合併したOsler-Rendu-Weber病の高齢女性の1例

    峯岸 慎太郎, 重政 朝彦, 小林 俊一, 糟谷 深

    Circulation Journal   72 ( Suppl.III )   1085 - 1085   2008.10

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  • 肺癌の心筋転移が疑われた1例

    渡部 まき, 重政 朝彦, 小林 俊一, 糟谷 深, 峯岸 慎太郎, 桐原 真梨子, 井上 のぞみ, 織田 寛子, 鍔本 奈央, 浦川 英樹

    超音波医学   35 ( 4 )   472 - 472   2008.7

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  • 当院における低左室機能患者に対する心臓リハビリテーションの現状

    重政 朝彦, 小林 俊一, 糟谷 深, 峯岸 慎太郎

    循環制御   29 ( Suppl. )   89 - 89   2008.5

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  • Stanford B型大動脈解離発症4年後にA型急性大動脈解離を発症したループス腎炎の1例(第2報)

    峯岸 慎太郎, 重政 朝彦, 小林 俊一, 糟谷 深

    Circulation Journal   72 ( Suppl.II )   936 - 936   2008.4

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  • 大網原発gastrointestinal stromal tumorと確認された高齢女性の1例 Reviewed

    峯岸 慎太郎, 重政 朝彦, 小林 俊一, 糟谷 深, 志村 岳, 金岡 知彦, 北村 創

    日本老年医学会雑誌   45 ( 2 )   244 - 244   2008.3

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  • 当院における心不全患者に対する心臓リハビリテーションの取り組み

    伊藤 真紀, 重政 朝彦, 小林 俊一, 糟谷 深, 峯岸 慎太郎

    静岡県理学療法士会学術誌: 静岡理学療法ジャーナル   ( 16 )   103 - 103   2008.2

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  • MDCTが診断に有用であった左上大静脈遺残の2例

    重政 朝彦, 小林 俊一, 糟谷 深, 峯岸 慎太郎, 志村 岳, 金岡 知彦, 唐澤 英偉

    日本画像医学雑誌   26 ( 2 )   124 - 124   2008.1

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  • State of the Art 高血圧臨床研究の動向2008 高血圧から慢性心不全までの大規模介入試験からみたβ遮断薬の評価

    築山 久一郎, 小林 俊一, 峯岸 慎太郎

    Therapeutic Research   29 ( 1 )   9 - 32   2008.1

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  • 塩酸パロキセチン投与による薬剤性SIADHが考えられた1例

    糟谷 深, 重政 朝彦, 川口 実, 小林 俊一, 峯岸 慎太郎, 志村 岳, 金岡 知彦

    日本内分泌学会雑誌   83 ( 3 )   738 - 738   2007.12

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  • MDCTにて確認した左上大静脈遺残の1例

    糟谷 深, 重政 朝彦, 小林 俊一, 小林 泉, 岡田 興造, 峯岸 慎太郎

    Circulation Journal   71 ( Suppl.III )   1024 - 1024   2007.10

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  • 心臓周囲の構造物として観察された食道疾患の2例

    織田 寛子, 重政 朝彦, 小林 俊一, 糟谷 深, 峯岸 慎太郎, 渡部 まき, 桐原 真梨子, 井上 のぞみ, 鍔本 奈央

    超音波医学   34 ( 5 )   542 - 542   2007.9

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  • 下肢深部静脈血栓症(DVT)を伴った特発性血小板減少性紫斑病(ITP)の1例

    峯岸 慎太郎, 萩原 政夫, 須山 孝宏

    日本内科学会関東地方会   530回   19 - 19   2005.10

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Presentations

  • The Latest Evidence on Onco-Hypertension Invited

    Shintaro Minegishi

    The 8th Annual Meeting of the Japanese Onco-Cardiology Society  2025.10 

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  • Statement based on Systematic Review results Invited

    Shintaro Minegishi

    The 46th Annual Scientific Meeting of the Japanese Society of Hypertension  2024.10 

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  • Setting CQs and Building Evidence through Systematic Review Invited

    The 46th Annual Scientific Meeting of the Japanese Society of Hypertension  2024.10 

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  • Salt-sensitive hypertension with a perspective on potassium loss and body water retention mechanisms: a reconsideration of MR function. Invited

    Shintaro Minegishi

    The 67th Annual Meeting of the Japanese Society of Nephrology  2024.6 

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  • Management of hypertension in patients with cancer Invited

    Shintaro Minegishi

    The 45th Annual Scientific Meeting of Japanese Society of Hypertension  2023.9 

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    Event date: 2023.9

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  • Mineralocorticoid receptor activation leads to high blood pressure due to body potassium and water loss

    Shintaro Minegishi, Norihiko Morisawa, Kento Kitada, Johannes Wild, Yam Wan Keat, Hong Yu Han, Adriana Marton, Kaoru Minegishi, Lim Tzy Tiing, Tomoaki Ishigami, Kouichi Tamura, Akira Nishiyama, Jean Paul Kovalik, Jens Titze

    ISH 2022 : The 29th Scientific Meeting of the International Society of Hypertension  2022.10 

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    Event date: 2022.10

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  • Deoxycorticosterone abetate(DOCA) leads to elevated blood pressure due to loss of body water Invited

    Shintaro Minegishi, Kento Kitada, Norihiko Morisawa, Kengo Azushima, Akira Nishiyama Tomoaki Ishigami, Kouichi Tamura, Jens Titze

    Society for Hypertension Related Disease Model Research  2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • Causes of Essential Hypertension - From the perspective of water loss and body water retension mechanism - Invited

    Shintaro Minegishi

    Society for Hypertension Related Disease Model Research  2021.12 

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    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • Heart Failure Invited

    Shintaro Minegishi

    Certified Cardiovascular Disease Prevention Educator Seminar by the Japanese Society of Hypertension  2026.2 

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    Event date: 2026.2

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • Heart Failure Management: Exploring the Role of Potassium and Water Conservation Mechanisms Invited

    Shintaro Minegishi

    2025.5 

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    Event date: 2025.5

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  • Heart failure management focusing on potassium and water conservation mechanisms. Invited

    Shintaro Minegishi

    Navigating Hyperkalemia Management  2024.11 

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  • Examinations for Central Arterial Pulse Wave Indexes Among the Subjects with Higher AVI, API, Non-invasiveVascular Indexes

    The 46th Annual Scientific Meeting of the Japanese Society of Hypertension  2024.10 

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    Event date: 2024.10

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  • Examinations for characteristics and performances of Vascular Age (Bruno) introduced by using non-invasive vascular indexes (AVI, API, Aortic Aix)

    The 46th Annual Scientific Meeting of the Japanese Society of Hypertension  2024.10 

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    Event date: 2024.10

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  • Examination for characteristics and performances of Vascular Age (Bruno) introduced by using non-invasive vascular indexes (AVI, API, Aortic Aix)

    The 46th Annual Scientific Meeting of the Japanese Society of Hypertension  2024.10 

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    Event date: 2024.10

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  • Hypertension and the risk of developing cancer: a systematic review and meta-analysis

    The 46th Annual Scientific Meeting of the Japanese Society of Hypertension  2024.10 

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    Event date: 2024.10

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  • Frequency of Hypertension in Childhood Cancer Survivors: a systematic review and meta-analysis

    The 46th Annual Scientific Meeting of the Japanese Society of Hypertension  2024.10 

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  • Planning multicenter collaborative clinical studies Invited

    The 46th Annual Scientific Meeting of the Japanese Society of Hypertension  2024.10 

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    Event date: 2024.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • Relationships between Arterial Pressure volume Index and Absolute Risk Value by Hisayamacho Score

    The 46th Annual Scientific Meeting of the Japanese Society of Hypertension  2024.10 

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  • Do Interventions Using Devices Measuring Urinary Sodium - to - Potassium Ratio and Dietary/Urinary Sodium Concentration Lower Blood Pressure?: Systematic Review and Meta - Analysis Invited

    The 46th Annual Scientific Meeting of the Japanese Society of Hypertension  2024.10 

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    Event date: 2024.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • Salt-sensitive hypertension with a focus on potassium loss and body water preservation systems. Invited

    Shintaro Minegishi

    2024.9 

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    Event date: 2024.9

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  • Hypertension and the risk of cancer recurrence: a systematic review and meta-analysis

    Yoshinori Okazaki, Naohiro Komura Shintaro Minegishi Akira Horigome, Kyouko Hattori, Msanari Asai Youhei Hanaima, Tomoaki Ishigami, Kiyoshi Hibi Yuuichiro, Yano Akira Nishiyama

    The 7th Annual Meeting of the Japanese Onco-Cardiology Society  2024.8 

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    Event date: 2024.8

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  • Prognostic impact of angiotensin-converting enzyme inhibitors and angiotensin receptors blockers in cancer patients

    Satoshi Ishii Youhei, Hanajima Shintaro Minegishi Akira Horigome, Kyouko Hattori, Takumi Tokoro, Masanari Asai Yoshinori, Okazaki Naohiro, Komura, Tomoaki, Ishigami Kiyoshi Hibi Yuuichiro, Yano Akira Nishiyama

    The 7th Annual Meeting of the Japanese Onco-Cardiology Society  2024.8 

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    Event date: 2024.8

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  • Onco-cardiology Invited

    Shintaro Minegishi

    2024.7 

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  • 腫瘍循環器学-課題とOnco-Hypertensionへの取り組み-

    峯岸慎太郎

    がん関連地域連携セミナー  2024.6 

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    Event date: 2024.6

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • ACS Hotline

    Shintaro Minegishi

    2024.5 

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    Event date: 2024.5

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  • One-Month Treatment with Dapagliflozin Triggers Renal Water Conservation and Thus Prevents Osmotic Diuresis in Patients with Chronic Heart Failure

    Marton, Adriana, Saffari, Seyed Ehsan, Sun, Ruo-Ning, Nagel, Armin M., Linz, Peter, Lim, Tzy Tiing, Minegishi, Kaoru, Morisawa, Norihiko, Yam, Wan Kea, Minegishi, Shintaro, Totman, John J., Kitada, Kento, Wild, Johannes, Kovalik, Jean-Paul, Luft, Friedrich, Greasley, Peter J., Sim, David, Titze, Jens

    Journal of the American Society of Nephrology 34(11S):55-55  2023.11 

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    Event date: 2023.11

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  • Feasibility of new vascular index, API, showed complexity of coronary atherosclerosis.

    The 45th Annual Scientific Meeting of Japanese Society of Hypertension  2023.9 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Featured Research Session (HF/CM) Discussants (FRS5) Invited

    The 87th Annual Scientific Meeting of The Japanese Circulation Society  2023.3 

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    Event date: 2023.3

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  • Hypertension Basic Research Discussants Invited

    The 87th Annual Scientific Meeting of The Japanese Circulation Society  2023.3 

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    Event date: 2023.3

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  • Molecular insight into salt-sensitivity; the role of Atf3 and the generation of tubular specific KO mice . (2)

    Satoshi Mouri, Kosho Machida, Kazuki Maeda, Kento Matsumoto, Tabito Kino, Sae Saigo, Shintaro Minegishi, Takuya Sugawara, Kotaro Uchida, Kentaro Arakawa, Lin Chen, Michiko Sugiyama, Koichi Tamura, Tomoaki Ishigami

    ISH 2022 : The 29th Scientific Meeting of the International Society of Hypertension  2022.10 

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    Event date: 2022.10

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  • Molecular insight into salt-sensitivity; the role of Atf3 and the generation of tubular specific KO mice . (1)

    Kosuke Machida, Satoshi Mouri, Kazuki Maeda, Kento Matsumoto, Tabito Kino, Sae Saigo, Kotaro Uchida, Lin Chen, Shintaro Minegishi, Kentaro Arakawa, Michio Sugiyama, Koichi Tamura, Tomoaki Ishigami

    ISH 2022 : The 29th Scientific Meeting of the International Society of Hypertension  2022.10 

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  • Deoxycorticosterone acetate(DOCA) leads to elevated blood pressure due to loss of body water

    Shintaro Minegishi, Kento Kitada, Norihiko Morisawa, Kengo Azushima, Akira Nishiyama, Kouichi Tamura

    The Japanes Society of Hypertension  2021.10 

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    Event date: 2021.10

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  • How does salt intake increase muscle mass?

    Shintaro Minegishi

    Duke-NUS CVMD Internal Program Seminar  2019.9 

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    Event date: 2019.9

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  • 公益信託循環器学研究振興基金研究成果報告 Invited

    Shintaro Minegishi

    2019.2 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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  • Generation of Nedd4L C2 Domain Knock-out Mice and Their Phenotypic Examinations Using Metabolic Cages

    Shintaro Minegishi, Tomoaki Ishigami, Hisako Ushio, Nomi Araki, Masanari Umemura, Kazuaki Uchino, Yoshiyuki Toya, Satoshi Umemura

    The 34th Annual Scientific Meeting of the Japanese Society of Hypertension  2011.10 

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  • Differences among renin-angiotensin system blockade for the target organ damage in the model of sodium sensitive hypertension.

    Shintaro Minegishi, Tomoaki Ishigami, Hisako Ushio-Yamana, Satoshi Umemura

    21st Annual Scientific Meeting of the European Society of Hypertension(ESH).  2011.6 

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    Venue:Milan  

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  • Differences among renin-angiotensin system blockade for the target organ damage and angiotensin II induced SCN5A-Nedd4L activation with mineralocorticoid receptor transactivaion in the model of sodium sensitive hypertension.

    Shintaro Minegishi, Tomoaki Ishigami, Hisako Ushio-Yamana, Satoshi Umemura

    2011 American Physiological Society Conference  2011.9 

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  • Role of Tubular Renin Angiotensin Systems for Sodium Sensitive Hypertension in Mice

    Shintaro Minegishi, Tomoaki Ishigami, Hisako Yamana, Nomi Araki, Masanari Umemura, Kazuaki Uchino, Satoshi Umemura

    The 35th Annual Scientific Meeting of the Japanese Society of Hypertension  2012.9 

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  • Nedd4L with C2 domain protein is critical for renal and cardiovascular adaptations to oral sodium intake- Experiments using Nedd4L C2 knockout mice. International conference

    Shintaro Minegishi, Tomoaki Ishigami, Hisako Ushio-Yamana, Nomi Araki, Masanari Umemura, Kaito Abe, Satoshi Umemura

    The 29th Annual Meeting of the International Society for Heart Research Japanese Section  2012.10 

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  • 大網原発 gastrointestinal stromal tumor (GIST) と確認された高齢女性の1例

    峯岸慎太郎, 重政朝彦, 小林俊一, 糟谷深, 志村岳, 金岡知彦, 北村創

    第18回 日本老年医学会東海地方会  2007.9 

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  • Angiotensin II induced SCN5A-Nedd4L transcriptional activation with mineral corticoid receptor transactivation in cardiomyocytes.

    Shintaro Minegishi, Tomoaki Ishigami, Hisako Ushio, Nomi Araki, Masanari Umemura, Yoshiyuki Toya, Kazuaki Uchino, Satoshi Umemura

    20th Annual Scientific Meeting of the European Society of Hypertension(ESH).  2010.6 

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    Venue:Oslo  

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  • Renin angiotensin antagonists suppress aberrant activation of epithelial sodium channels in sodium-sensitive hypertension.

    Shintaro Minegishi, Tomoaki Ishigami, Hisako Ushio, Nomi Araki, Satoshi Umemura

    The 5th International Aldosterone Forum in Japan  2012.5 

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  • Nedd4L C2ドメインノックアウトマウスの作成と表現型の解析

    峯岸慎太郎, 石上友章, 山名比早子, 新城名保美, 梅村将就, 内野和顕, 梅村敏

    第3回 分子腎臓フォーラム  2012.9 

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  • Sodium channel-Nedd4L-proteasome systems play a pivotal role for electrophysiological cardiovascular adaptations International conference

    Minegishi Shintaro, Tomoaki Ishigami, Tabito Kino, Lin Chen, Rie Nakashima, Naomi Araki, Hiroshi Doi, Michiko Sugiyama, Satoshi Umemura

    The 32nd Annual Meeting of the International Society for Heart Research Japanese Section, CVMW2015  2015.12 

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    Minegishi Shintaro

    MS943673  2016.2 

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  • 早朝高血圧患者におけるαβ遮断薬とα遮断薬の夕食後服用による降圧効果の比較

    峯岸慎太郎, 石上友章, 持田泰行, 梅村敏

    第3回 臨床高血圧フォーラム  2014.5 

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  • 急性冠症候群を契機に発見されたStaphylococcus lugdunensisによる感染性心内膜炎の一例

    峯岸慎太郎, 降旗修太, 市川晋也, 福岡雅浩, 神原かおり, 持田泰行

    第232回 日本循環器学会関東甲信越地方会  2014.6 

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  • Impaired post-transcriptional modification for sodium channel caused cardiac electrophysiological involvements as cardio-renal association in salt sensitive hypertension of Nedd4-2 C2 KO mice International conference

    Shintaro Minegishi, Hisho Kawamura, Tabito Kino, Lin Chen, Rie Nakashima, Hiroshi Doi, Satoshi Umemura, Tomoaki Ishigami

    RAAS2016 (ISH 2016 satellite symposium)  2016.9 

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  • An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice

    Shintaro Minegishi, Tomoaki Ishigami, Tabito Kino, Lin Chen, Rie Nakashima-Sasaki, Naomi Araki, Keisuke Yatsu, Megumi Fujita, Satoshi Umemura

    JSH 2016  2016.9 

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  • Examinations of the role of SCN5A-Nedd4-2 system for regulation of myocardial action potential

    Shintaro Minegishi, Tabito Kino, Rie Nakashima, Lin Chen, Hiroshi Doi, Hisho Kwawamura, Michiko Sugiyama, Satoshi Umemura, Tomoaki Ishigami

    JSH 2016  2016.10 

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  • Nedd4-2 C2ノックアウトマウスを用いた心房細動の誘発 に対する影響の検討

    CVEM (Cardiovascular Endocrinology and Metabolism)  2016.12 

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  • Naチャネル調節因子Nedd4-2の心臓電気生理学的表現型に与える影響の解析

    川村飛翔, 峯岸慎太郎, 中島理恵, 土肥宏志, 陳琳, 木野旅人, 石川義弘, 藤田孝之, Rajesh Plajapati, 石上友章, 田村功一

    第243回 日本循環器学会関東甲信越地方会 Student Award  2017.2 

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  • Rethinking “salt-sensitive” hypertension

    Shintaro Minegishi, Jens Titze

    Duke-NUS CVMD Internal Program Seminar  2022.2 

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  • 168) Stanford B型大動脈解離発症4年後にA型急性大動脈解離を発症したループス腎炎の1例(第2報)(日本循環器学会第130回東海・第115回北陸合同地方会)

    峯岸 慎太郎, 重政 朝彦, 小林 俊一, 糟谷 深

    Circulation journal : official journal of the Japanese Circulation Society  2008.4 

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  • 下肢深部静脈血栓症(DVT)を伴った特発性血小板減少性紫斑病(ITP)の1例

    峯岸慎太郎, 萩原政夫, 須山孝宏

    第530回 日本内科学会関東地方会  2005.10 

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  • 食塩感受性高血圧モデルにおける臓器障害に対するRA系降圧薬の効果の検討

    The 33rd Annual Scientific Meeting of the Japanese Society of Hypertension  2010.10 

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  • 食塩感受性高血圧における心臓臓器障害に対するレニン・アンジオテンシン系阻害薬の効果の検討

    峯岸慎太郎, 牛尾比早子, 新城名保美, 石上友章, 梅村敏

    第16回 アンジオテンシンカンファレンス  2011.2 

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  • 93) 心不全を合併したOsler-Rendu-Weber病の高齢女性の1例(第131回日本循環器学会東海地方会)

    峯岸 慎太郎, 重政 朝彦, 小林 俊一, 糟谷 深

    Circulation journal : official journal of the Japanese Circulation Society  2008.10 

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Awards

  • New Investigator oral presentation Award Finalist

    2022.10   ISH2022: The 29th Scientific Meeting of the International Society of Hypertension   Mineralocorticoid receptor activation leads to high blood pressure due to body potassium and water loss

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  • Splendid basic Hypertension Research Award

    2021.10   The 43rd Annual Scientific Meeting of the Japanese Society of Hypertension   Deoxycorticosterone acetate(DOCA) lead to elevated blood pressure due to loss of body water

    Shintaro Minegishi, Kento Kitada, Norihiko Morisawa, Kengo Azushima, Akira Nishiyama, Tomoaki Ishigami, Kouichi Tamura

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  • 同門会賞 優秀賞

    2017.12   横浜市立大学医学部第二内科同門会  

    峯岸 慎太郎

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  • The 39th Annual Scientific Meeting of the Japanese Society of Hypertension Young Investigator’s Award First Prize

    2016.9   Japanese Society of Hypertension   An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice

    Minegishi Shintaro

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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  • Featured Research Session

    2012.10   The 29th International Society for Heart Research (ISHR), Japanese Section   Nedd4L with C2 domain protein is critical for renal and cardiovascular adaptations to oral sodium intake- Experiments using Nedd4L C2 knockout mice.

    Minegishi Shintaro

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Research Projects

  • 腎K+排泄と体液保持機構に着目したMR関連高血圧とMR拮抗薬の心保護作用の解明

    Grant number:25K11502  2025.4 - 2029.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    峯岸 慎太郎

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    Authorship:Principal investigator 

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

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  • 免疫チェックポイント阻害薬心筋炎の新規バイオマーカー開発

    2023.11 - 2025.3

    TERUMO LIFE SCIENCE FOUNDATION  Research Grant 

    Shintaro Minegishi, Yohei Miyagi, Tomoaki Ishigami

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  • New Biomarker for Cardiac Adverse Events Induced by Immune Checkpoint Inhibitors

    2023.4 - 2024.3

    YOKOHMA ACADEMIC FOUNDATION  Research Grant 

    Shintaro Minegishi

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  • 機械学習により心電図データから換気障害を予測するアルゴリズムの構築

    Grant number:22K08235  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    堀田 信之, 峯岸 慎太郎

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    換気障害を呈する疾患の診断は呼吸機能検査にもとづく。しかし、専用機器の設置や指導する医療者立ち合いの必要性などの問題から検査が普及せず、多くの呼吸器疾患患者が未診断となっている。これに対し私たちは、旧来言及されていた肺疾患と心電図との関係性について、多施設共同研究にて診療に生かせるエビデンスの検証を行う。具体的には、5万人の患者の心電図データと呼吸機能データを人工知能で解析して、心電図による換気障害判定アルゴリズムを構築する。これを5万人のテストデータで検証後、心電図計併設自動解析ソフトに実装する。また、マウスモデルを用いて、心電図所見と病理所見の対比から、換気障害に伴う心電図変化の生理学的原因を解明する。心電図で簡便に換気障害疑いを検知できれば、早期診断・介入が可能となる。また、生理学的裏付けは検査のエビデンスレベルを向上させる。
    本研究の目的は、心電図による呼吸機能障害判定アルゴリズムの構築と、それを心電図計併設自動解析ソフトへ実装し、「閉塞性/拘束性換気障害疑い」のコメントを出力することである。肺性心患者と正常者、あるいは、慢性閉塞性肺疾患(COPD)患者と正常者の心電図を比較する研究は、複数報告されている。しかし、心電図を換気障害の診断に用いる、という視点の研究は行われていない。
    現在約2万例のデータを抽出し、解析試行中である。

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  • Elucidation of the molecular mechanism of SCN5A-Nedd4-2 for lethal arrhythmia

    Grant number:20K17124  2020.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Minegishi Shintaro

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    In addition to elucidating the molecular mechanism of the SCN5A-Nedd4-2 system in lethal arrhythmias, which is the subject of this application, we are developing research on DOCA-loaded mice. In contrast to the conventional renal theory that impaired sodium excretion and increased extracellular fluid volume in the kidney cause increased "circulating blood volume" and "hypertension," experiments in DOCA-loaded mice have shown that increased "peripheral vascular resistance" and "hypertension" may occur as a multifactorial physiological adaptation for the purpose of preventing water loss in the body. This activation of fluid conservation mechanisms might be a key factor in the development of hypertension in the body. Activation of these fluid retention mechanisms may result in "treatment-resistant hypertension. Aldosterone secretion increases potassium excretion, resulting in water loss.

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  • Evaluation of effects on age and tissue regeneration by exercise intervention on high-risk myocardial infarction

    Grant number:18K19689  2018.6 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    CHIBA Yumi

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    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

    In recent years, regenerative medicine using stem cells for damaged myocardium after myocardial infarction has attracted much attention, and the perspective of how to prevent fibrosis is an important issue. Especially in Japan, where the population is aging rapidly, there is an urgent need to evaluate stem cells, discover the usefulness of introducing cells into the body, and elucidate the mechanisms that lead to treatment in order to realize effective medical care after myocardial infarction. Cortical bone-derived stem cells are a new type of stem cells that have shown some usefulness in myocardial regeneration in the United States. In Japan, these stem cells were isolated and analyzed for therapeutic application, and new findings were obtained.

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  • Development and Evaluation of Rehabilitation Program depending on Patients with Severe Body and Dysphagic Conditions

    Grant number:17H04458  2017.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    CHIBA Yumi

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    Grant amount:\16770000 ( Direct Cost: \12900000 、 Indirect Cost:\3870000 )

    When creating a program for critically ill patients (patients with cardiovascular diseases) according to their feeding and swallowing functions, the number of valid English-language articles on the survey items is still insufficient. Based on the specific discussions among the experts on the content of this project, it was confirmed that it is important to conduct a pre-survey in the first phase, as well as to identify missing survey items and select necessary items from a clinical perspective, in order to create a clinical practice program of higher quality. It was considered necessary to obtain information from experts in the cardiovascular system (surgery and internal medicine) and advanced practitioners providing advanced medical care. Based on visits to the USA, we gained a qualitative understanding of the factors that are necessary for a medical system of patients with cardiovascular diseases.

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  • Analyses of molecular mechanism of electrophysiological remodeling focusing on SCN5A-Nedd4-2

    Grant number:17K16019  2017.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Minegishi Shintaro, ISHIGAMI tomoaki

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    We demonstrated that Nedd4-2 C2 isoform causes cardiac conduction change in resting condition as well as proarrhythmic change after acute myocardial infarction (MI) and atrial fibrillation (AF). The Nedd4-2 C2 knockout (KO) mice showed prolonged QRS, QT intervals, and suppressed PR interval in resting condition.
    Although KO showed higher sympatho-vagal balance, bradycardia was found. In addition, enhancement of T peak/T end interval was found in mice with surgical MI. Burst pacing induced AF was sustained in KO. Morphological analyses based on both ultrasonography of the living heart, as well as histopathological findings revealed that KO mice show no significant structural change.
    These results suggested that Nedd4-2 with C2 domain might play an important role through post-transcriptional modification of ion channels.

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  • 体液・電解質・血圧の恒常性維持におけるB細胞の役割

    2017.4 - 2018.3

    公益財団法人 日本心臓財団  第30回日本心臓財団・バイエル薬品海外留学助成 

    峯岸 慎太郎

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3000000

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  • 致死的不整脈とSCN5A-Nedd4-2系の電気的リモデリングに関する病態

    2017.2 - 2019.1

    三井住友信託銀行  公益信託 循環器学研究振興基金 

    峯岸 慎太郎

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000

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  • Influence of aging and exercise on engraftment after stem cell transplantation into myocardial infarction model mice

    Grant number:26671017  2014.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    CHIBA Yumi, SASAKI Norihiko, ITAKURA Yoko, NAKASHIMA Rie

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    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    Heart diseases in the elderly are at the top of the cause of death, and treatment options are limited by severity. One means to solve this problem can be said to establish a treatment method by myocardial regeneration by stem cell transplantation. In this study, the aim is to lead appropriateness of the safety and effectiveness of stem cell transplantation in human heart disease pathology by making and evaluating disease model animals to solve this task. Until now, myocardial infarction occurred in young and old mice, and almost completed the evaluation system of heart functions based on ultrasonic evaluation and so on. On the other hand, with regard to the establishment and culture of stem cells as a source of stem cell transplantation to the site of myocardial infarction, both isolation and culture started smoothly, and they are progressing without problems. In the future we will continue to transplant to a disease model.

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Teaching Experience

  • Onco-cardiology

    2024.7

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  • Myocarditis and Pericardial Disorders

    2022.10 Institution:Department of Medicine, Yokohama City University

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Media Coverage

  • The Japan Society of Hypertension discusses efforts to address "Onco-Hypertension," hypertension associated with cancer treatment. Internet

    CANCER CARDIO-NET  https://www.cancercardio.net/articles/0031/  2023.9

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  • Managing Hypertension is Important for Cancer Treatment and Heart Health -Why Onco-Hypertension? Internet

    CANCER CARDIO-NET  https://www.cancercardio.net/articles/0026/index.html  2023.4

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    Author:Myself 

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  • がん免疫療法に伴う高血圧のリスクを検証 ーOnco-Hypertensionという新規分野の研究成果ー

    https://www.yokohama-cu.ac.jp/news/2022/minegishishintaro.html  2022.9

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  • 循環器内科学 石上准教授ら研究グループが食塩感受性・高血圧の分子レベルでの病態の解明に成功

    https://www.yokohama-cu.ac.jp/amedrc/news/20160622.html  2016.6

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