Updated on 2025/11/21

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写真a

 
Kaname Sato
 
Organization
Graduate School of Medicine Department of Medicine Otorhinolaryngology Head and Neck Surgery Assistant Professor
School of Medicine Medical Course
Title
Assistant Professor
External link

Degree

  • Doctor of Philosophy ( Yokohama City University )

Research Interests

  • 頭頚部癌

  • がんの浸潤・転移

  • バイオインフォマティクス

  • 腫瘍内低酸素

  • P4HA1

Research Areas

  • Life Science / Otorhinolaryngology

Papers

  • Factors Related to Blood Loss During Endoscopic Sinus Surgery. International journal

    Yamato Oki, Hiromitsu Hatakeyama, Kouzi Yamamoto, Kenta Hukui, Shota Yamada, Kizima Natsumi, Tai Iwamura, Yu Matsumoto, Kaname Sato, Nobuhiko Oridate

    Cureus   16 ( 12 )   e76286   2024.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: The safety and efficacy of endoscopic sinus surgery have improved with the development of new equipment and improved surgical techniques. However, it is accompanied by the risk of complications. Intraoperative blood loss is an important factor in the safe conduct of surgery. Therefore, we examined the factors associated with intraoperative blood loss. METHOD: The amount of intraoperative bleeding experienced by 518 patients with sinonasal disease who underwent endoscopic sinus surgery under general anaesthesia at our hospital over nine years was tabulated. Thirty-four variables were extracted after analysis of patients' background, sinonasal pathology, and haematology results. Multivariate linear regression analysis was performed. RESULTS: Multivariate analysis revealed significant differences in the prothrombin time-international normalized ratio (PT-INR), Lund-Mackay score, operative time, and initial versus repeat surgery. The degree of change between the 25% and 75% points was significant for the following variables: an increase from 5 to 14 points for the Lund-Mackay score at 73 mL. CONCLUSIONS: Preoperative precautionary measures should be implemented in the event of re-operation, expected prolonged operative time, high Lund-Mackay score, and prolonged PT-INR. Intraoperative blood loss in patients with a high Lund-Mackay score requires meticulous attention.

    DOI： 10.7759/cureus.76286

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  • ペムブロリズマブ初回投与後にスティーブンス・ジョンソン症候群を発症するも腫瘍の著明縮小に至った蝶形骨洞癌の一例

    岡田 花子, 高橋 秀聡, 木谷 洋輔, 塚本 文彦, 逸見 真弘, 松本 佑夏, 大平 彩菜, 佐藤 要, 佐野 大佑, 西村 剛志, 折舘 伸彦

    神奈川医学会雑誌   51 ( 2 )   83 - 83   2024.7

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    Language：Japanese   Publisher：(公社)神奈川県医師会  

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  • 急激な経過をたどった頸部発生NUT carcinomaの症例

    岡田 花子, 丹羽 一友, 田辺 美樹子, 田中 玲子, 川野 雅子, 伊藤 華純, 吉田 興平, 大氣 大和, 桑原 達, 佐藤 要, 磯野 泰大, 高橋 秀聡, 折舘 伸彦, 畠山 博充

    日本耳鼻咽喉科頭頸部外科学会会報   127 ( 6 )   721 - 725   2024.6

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  • 急激な経過をたどった頸部発生NUT carcinomaの症例

    岡田 花子, 丹羽 一友, 田辺 美樹子, 田中 玲子, 川野 雅子, 伊藤 華純, 吉田 興平, 大氣 大和, 桑原 達, 佐藤 要, 磯野 泰大, 高橋 秀聡, 折舘 伸彦, 畠山 博充

    日本耳鼻咽喉科頭頸部外科学会会報   127 ( 6 )   721 - 725   2024.6

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  • P4HA1は下咽頭扁平上皮癌の遊走能とコロニー形成能を促進する

    佐藤 要, 佐野 大佑, 高橋 秀聡, 西村 剛志, 折舘 伸彦

    頭頸部癌   50 ( 2 )   158 - 158   2024.5

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    Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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  • 視覚障害を呈した副鼻腔嚢胞の臨床的検討

    大氣 大和, 鬼島 菜摘, 福井 健太, 山田 将大, 岩村 泰, 二宮 啓彰, 松本 悠, 桑原 達, 佐藤 要, 磯野 泰大, 丹羽 一友, 大庭 万優, 畠山 博充, 折舘 伸彦

    日本耳鼻咽喉科頭頸部外科学会会報   127 ( 2 )   121 - 128   2024.2

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  • 血管塞栓術を要さず内視鏡的に摘出しえた鼻中隔glomangiopericytomaの1例

    大氣 大和, 坪倉 杏奈, 福井 健太, 吉田 興平, 桑原 達, 佐藤 要, 磯野 泰大, 丹羽 一友, 畠山 博充, 折舘 伸彦

    耳鼻咽喉科・頭頸部外科   96 ( 2 )   184 - 188   2024.2

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    Language：Japanese   Publisher：(株)医学書院  

    症例は81歳男性で、右鼻出血を主訴とした。誘因なく鼻出血が出現し、止血困難であった。右中鼻甲介内側に出血を伴う赤色腫瘍性病変を認めた。副鼻腔造影CTにて、右鼻腔内に造影効果のある長径35mmの腫瘤を認めた。骨破壊や浸潤はみられなかった。副鼻腔造影MRIでは、境界明瞭でT1で低信号、T2で高信号の造影効果をもつ腫瘤を認めた。生検を行い、glomangiopericytomaや血管系腫瘍などが疑われる所見であった。以上より、glomangiopericytomaを疑い、内視鏡手術で一塊に摘出することとした。5mmほどのマージンをつけて鼻中隔粘膜を切開し、栄養血管と考えられる蝶口蓋動脈中隔後鼻枝は焼灼・切断し、腫瘍を一塊に摘出した。術中出血量は50mLで、出血は制御可能であった。免疫染色にて、glomangiopericytomaと診断した。術後出血はなく、術後3年経過後も再発は認められていない。

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  • P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma. International journal

    Kaname Sato, Daisuke Sano, Hideaki Takahashi, Tatsu Kuwahara, Yoshihiro Aizawa, Jun Aoyama, Yusuke Nojima, Takashi Hatano, Yasuhiro Arai, Goshi Nishimura, Hiromitsu Hatakeyama, Nobuhiko Oridate

    Anticancer research   43 ( 6 )   2571 - 2582   2023.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND/AIM: This study aimed to identify key molecules associated with the survival of patients with hypopharyngeal squamous cell carcinoma (HpSCC) by combining in silico and in vitro analyses. MATERIALS AND METHODS: Differentially expressed genes (DEGs) were screened using the Gene Expression Omnibus database. For DEGs, we performed functional enrichment and protein-protein interaction network analyses to identify potential biological functions and hub genes. Functional analysis of HpSCC cell lines verified the critical roles of the hub genes. RESULTS: DEGs were associated with the extracellular matrix. Among the hub genes, high expression of prolyl 4-hydroxylase subunit alpha 1 (P4HA1) was significantly associated with shorter survival. In addition, P4HA1 knockdown inhibited cell migration and colonization. Suppression of cell proliferation was demonstrated using P4HA1-selective inhibitors. CONCLUSION: P4HA1 may be a useful therapeutic target for the treatment of HpSCC.

    DOI： 10.21873/anticanres.16424

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  • Fibrinogen-to-lymphocyte Ratio Predicts the Outcomes of Hypopharyngeal Squamous Cell Carcinoma Treated With Definitive Radiotherapy. International journal

    Kaname Sato, Hiromitsu Hatakeyama, Hanako Okada, Masako Kawano, Kohei Yoshida, Yamato Oki, Tatsu Kuwahara, Kazutomo Niwa, Yasuhiro Isono, Nobuhiko Oridate

    In vivo (Athens, Greece)   37 ( 3 )   1281 - 1289   2023

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    BACKGROUND/AIM: Previous studies have identified several inflammatory biomarkers that are useful as prognostic biomarkers for various cancer types. However, the fibrinogen-to-lymphocyte ratio (FLR) has not been addressed in head and neck squamous cell carcinoma. Here, we aimed to examine the value of pretreatment FLR as a prognostic marker in patients who received definitive radiotherapy for hypopharyngeal squamous cell carcinoma (HpSCC). PATIENTS AND METHODS: This retrospective study included 95 patients treated with definitive radiotherapy for HpSCC between 2013 and 2020. The prognostic factors for progression-free (PFS) and overall (OS) survival were identified. RESULTS: The optimal cut-off value of pretreatment FLR for discriminating PFS was 2.46. Based on this value, 57 and 38 patients were classified into groups with high and low FLR, respectively. A high FLR was significantly associated with advanced local disease and overall stage, and with the development of synchronous second primary cancer compared with a low FLR. The high FLR group had significantly lower PFS and OS rates than the low FLR group. Multivariate analysis showed that having a high pretreatment FLR was an independent prognostic factor for poorer PFS and OS [PFS: hazard ratio (HR)=2.14, 95% confidence interval (CI)=1.09-4.19, p=0.026; OS: HR=2.86, 95% CI=1.14-7.20, p=0.024]. CONCLUSION: The FLR has a clinical effect on PFS and OS in patients with HpSCC, suggesting that it has potential application as a prognostic factor for patients with HpSCC.

    DOI： 10.21873/invivo.13206

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  • FosL1 Regulates Regional Metastasis of Head and Neck Squamous Cell Carcinoma by Promoting Cell Migration, Invasion, and Proliferation. International journal

    Hiroshi Hyakusoku, Kae Sawakuma, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Kaname Sato, Yasuhiro Isono, Shoko Shimada, Kentaro Takada, Tatsu Kuwahara, Yoshihiro Aizawa, Nobuhiko Oridate

    Anticancer research   41 ( 7 )   3317 - 3326   2021.7

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    BACKGROUND/AIM: We evaluated the impact of FosL1, a member of the activated protein-1 family, on the pathways leading to regional metastasis of head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: We examined the influence of small interfering RNA (siRNA) and short heparin RNA (shRNA) mediated knockdown of FosL1 on cell migration, invasion, and proliferation in vitro as well as on regional metastasis in vivo. The prognostic significance of FosL1 was also analyzed using the Kaplan- Meier plotter using data from an HNSCC patient database. RESULTS: Down-regulation of FosL1 inhibited cell migration, invasion, and proliferation in vitro, decreased the incidence of regional metastases, and prolonged the survival of mice in vivo. We also determined that HNSCC patients with higher expression levels of FosL1 had a significantly shorter survival time than those with low expression of FosL1. CONCLUSION: FosL1 plays a crucial role in promoting cell migration, invasion, and proliferation in HNSCC.

    DOI： 10.21873/anticanres.15119

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  • Establishment of PDX-derived salivary adenoid cystic carcinoma cell lines using organoid culture method. International journal

    Kentaro Takada, Yoshihiro Aizawa, Daisuke Sano, Ryo Okuda, Keisuke Sekine, Yasuharu Ueno, Shoji Yamanaka, Jun Aoyama, Kaname Sato, Tatsu Kuwahara, Takashi Hatano, Hideaki Takahashi, Yasuhiro Arai, Goshi Nishimura, Hideki Taniguchi, Nobuhiko Oridate

    International journal of cancer   148 ( 1 )   193 - 202   2021.1

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    To generate a reliable preclinical model system exhibiting the molecular features of salivary adenoid cystic carcinoma (ACC) whose biology is still unclear due to the paucity of stable cell cultures. To develop new in vitro and in vivo models of ACC, the techniques of organoid culture and patient-derived tumor xenograft (PDX), which have attracted attention in other malignancies in recent years, were applied. Tumor specimens from surgically resected salivary ACC were proceeded for the preparation of PDX and organoid culture. The orthotopic transplantation of patient-derived or PDX-derived organoids was demonstrated into submandibular glands of NSG mice and those histology was evaluated. PDX-derived organoid cells were evaluated for the presence of MYB-mediated fusion genes and proceeded for in vitro drug sensitivity assay. Human ACC-derived organoids were successfully generated in three-dimensional culture and confirmed the ability of these cells to form tumors by orthotopic injection. Short-term organoid cell cultures from two individual ACC PDX tumors were also established that maintain the characteristic MYBL1 translocation and histological features of the original parent and PDX tumors. Finally, the establishment of drug sensitivity tests on these short-term cultured cells was confirmed using three different agents. This is the first to report an approach for the generation of human ACC-derived organoids as in vitro and in vivo cancer models, providing insights into understanding of the ACC biology and creating personalized therapy design for patients with ACC.

    DOI： 10.1002/ijc.33315

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  • 癌細胞のp53喪失は癌微小環境における神経の成長と再プログラムを通じて癌の進展を促す

    高橋 秀聡, 佐野 大佑, 波多野 孝, 佐藤 要, 桑原 達, 相澤 圭洋, 青山 準, 折舘 伸彦

    日本癌学会総会記事   79回   OE11 - 8   2020.10

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  • 癌細胞のp53喪失は癌微小環境における神経の成長と再プログラムを通じて癌の進展を促す

    高橋 秀聡, 佐野 大佑, 波多野 孝, 佐藤 要, 桑原 達, 相澤 圭洋, 青山 準, 折舘 伸彦

    日本癌学会総会記事   79回   OE11 - 8   2020.10

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  • FOSL1 promotes regional metastasis of head and neck squamous cell carcinoma Reviewed

    Sano Daisuke, Sawakuma Kae, Hyakusoku Hiroshi, Hatano Takashi, Isono Yasuhiro, Takada Kentaro, Sato Kaname, Kuwahara Tatsu, Aizawa Yoshihiro, Oridate Nobuhiko

    CANCER SCIENCE   109   526   2018.12

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  • Analysis of prognostic factors, including the incidence of second primary cancer, in patients with early stage laryngeal squamous cell carcinoma treated by radiation-based therapy

    Kaname Sato, Kenichiro Yabuki, Daisuke Sano, Yasuhiro Arai, Yoshihiro Chiba, Teruhiko Tanabe, Goshi Nishimura, Masaharu Hata, Nobuhiko Oridate

    Translational Cancer Research   7 ( 4 )   890 - 900   2018.8

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    DOI： 10.21037/tcr.2018.06.15

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  • Primary definitive radiotherapy with or without chemotherapy for squamous cell carcinoma of the temporal bone. International journal

    Yosuke Kitani, Akira Kubota, Madoka Furukawa, Kaname Sato, Yuko Nakayama, Tetsuo Nonaka, Nobutaka Mizoguchi

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery   273 ( 5 )   1293 - 8   2016.5

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    We aimed to evaluate the impact of concurrent chemoradiotherapy (CCRT) on the survival of patients with squamous cell carcinoma of the temporal bone. We retrospectively analyzed the data of 13 consecutive patients who were treated by definitive radiation therapy (RT) or CCRT as the initial treatment between 1999 and 2012. There were 5 patients with stage II disease, 5 with stage III, and 3 with stage IV, as classified according to the University of Pittsburgh system. Among these, 2, 4, and 3 patients, respectively, were treated by CCRT; whereas the remaining (3 patients with stage II and 1 with stage III) were treated by RT alone. Median follow-up duration was 39 months (12-106 months) in all cases, and 61.5 months (17-70 months) in censored cases. The 5-year overall survival (OS) rates were 51 % in all patients, and 40, 100, and 0 % in patients with stage II, stage III, and stage IV disease, respectively. In patients with stage II and III disease, the 5-year OS rates were 80 % in the CCRT group and 50 % in the RT-alone group. We found better prognosis in patients with stage II and III disease who were treated by CCRT. Only 2 patients treated by CCRT experienced adverse events more than grade 3, which were neutropenia and dermatitis. There was no late adverse event of bony necrosis. Our study results indicate that CCRT is safe and very effective as a first-line treatment for stage II and III squamous cell carcinoma of the temporal bone.

    DOI： 10.1007/s00405-015-3616-7

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  • Prognostic factors for local control in patients receiving radiation therapy for early glottic cancer: anterior commissure involvement and effect of chemoradiotherapy. International journal

    Yosuke Kitani, Akira Kubota, Madoka Furukawa, Kaname Sato

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery   273 ( 4 )   1011 - 7   2016.4

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    To assess the prognostic factors for local control in patients with early glottic cancer, we retrospectively analyzed the data of 130 consecutive patients who were treated by definitive radiation therapy (RT) or concurrent chemoradiotherapy (CRT) for early glottic squamous cell carcinoma (UICC sixth edition T1N0M0 and T2N0M0) at Kanagawa cancer center between 1999 and 2011. There were 63 patients with T1 cancer and 67 patients with T2 cancer. Twenty-one patients with T2 tumors were treated by chemoradiotherapy (CRT). The median follow-up period was 73 months (range, 22-165 months). The 5-year local control (LC) rate in all patients was 81 %. The 5-year LC rates in the patients with T1 and T2 cancer were 89 and 74 %, respectively. Univariate analysis showed that a higher T stage (T2) (p = 0.0301), anterior commissure involvement (p < 0.000001), and habitual drinking (p = 0.054) were correlated with decreased local control rate. Multivariate analysis identified only anterior commissure involvement as a significant prognostic factor for local control (LC rate 91 vs. 51 %, risk ratio 5.3, 95 % CI 2.3-12, p < 0.001). In the patients with T2 cancer, there was no statistically significant difference in the LC rate between patients who received RT alone and those who received CRT (RT alone 76 % vs. CRT 67 %; p = 0.832). The findings of this study suggest that anterior commissure involvement is a significant factor influencing the prospect of local control. CRT was not found to be effective for T2 patients in this study.

    DOI： 10.1007/s00405-015-3579-8

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  • Definitive radiotherapy for early-stage hypopharyngeal squamous cell carcinoma. International journal

    Kaname Sato, Akira Kubota, Madoka Furukawa, Yousuke Kitani, Yuko Nakayama, Tetsuo Nonaka, Nobutaka Mizoguchi, Miho Shiomi

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery   272 ( 8 )   2001 - 6   2015.8

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    The present study analyzed the outcomes of patients with early-stage hypopharyngeal squamous cell carcinoma (HPSCC) treated with radical radiotherapy (RT) or concurrent chemoradiotherapy (CCRT). We retrospectively reviewed the clinical records of 33 patients with early-stage HPSCC who underwent RT or CCRT between January 1999 and December 2011. Of the 33 patients who were treated, 12 had Stage I and 21 had Stage II disease. Patients with Stage I were typically treated with RT, while patients with Stage II were treated with CCRT (concurrent chemotherapy: 5FU, cisplatin or TS-1). The median follow-up period was 81 months, ranging from 15 to 155 months. The 5-year overall survival rates, cause specific survival rates, locoregional control rates, and progression-free survival rates were 58, 75, 56, and 49 %, respectively. Of the 33 patients, 51 % experienced second primary malignancies. Esophageal carcinoma occurred in several cases, and was diagnosed either during screening after treatment for the second primary malignancy or simultaneously with the second primary malignancy. Advanced-stage second malignancies significantly influenced the survival of the patients and the control rate for HPSCC. Treatment emphasizing the quality of life after treatment is needed, if a poor prognosis is expected because of advanced-stage second primary malignancy.

    DOI： 10.1007/s00405-014-3132-1

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  • A 7-year consecutive study on salivary duct carcinoma of the parotid gland: An institutional review

    Kaname Sato, Takahide Taguchi, Yuka Kitani, Yasuko Tanaka, Hideaki Takahashi, Yasuhiro Arai, Daisuke Sano, Masanori Komatsu, Goshi Nishimura, Masahiro Takahashi, Nobuhiko Oridate

    Japanese Journal of Head and Neck Cancer   40 ( 1 )   71 - 74   2014

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.5981/jjhnc.40.71

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Research Projects

  • Understanding the cancer microenvironment and identifying targeted therapeutic strategies in head and neck malignancies in the AYA generation

    Grant number：25K20147  2025.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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