Updated on 2025/06/03

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写真a

 
Miki Tanoshima
 
Organization
YCU Medical Center Genetic Diagnosis and Therapy Assistant Professor
Title
Assistant Professor
Homepage
http://www.ycuobgyn.jp/
External link

Degree

  • 医学博士 ( 横浜市立大学 )

Research Interests

  • バルプロ酸

  • 妊娠と薬

  • 周産期遺伝

  • 臨床遺伝

Research Areas

  • Life Science / Medical biochemistry  / 遺伝

  • Life Science / Obstetrics and gynecology  / 周産期

Research History

  • Yokohama City University Medical Center   Assistant Professor

    2021.4

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Papers

  • BRCA2 reversion mutation confers resistance to olaparib in breast cancer

    Shinya Yamamoto, Kei Kawashima, Yoshie Fujiwara, Shoko Adachi, Kazutaka Narui, Chiaki Hosaka, Rina Takahashi, Sho Tsuyuki, Makoto Sugimori, Miki Tanoshima, Mahato Sasamoto, Masanori Oshi, Akimitsu Yamada, Chikara Kunisaki, Itaru Endo

    Clinical Case Reports   11 ( 6 )   2023.6

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Key Clinical Message

    A rare missense mutation was identified as a reversion mutation using cancer genomic profiling and a suspected mechanism underlying resistance to olaparib in breast cancer.

    Abstract

    A 34‐year‐old woman with breast cancer and BRCA2: p.Gln3047Ter was treated with olaparib. After tumor progression, cancer genomic profiling testing using liquid biopsy revealed BRCA2 p.Gln3047Ter and p.Gln3047Tyr, with 48.9% and 0.37% allele frequency, respectively. These findings shed light on reversion mutation as a mechanism of resistance to olaparib in breast cancer.

    DOI： 10.1002/ccr3.7537

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  • Risks of Congenital Malformations in Offspring Exposed to Valproic Acid In Utero: A Systematic Review and Cumulative Meta-analysis Reviewed

    M. Tanoshima, T. Kobayashi, R. Tanoshima, J. Beyene, G. Koren, S. Ito

    CLINICAL PHARMACOLOGY & THERAPEUTICS   98 ( 4 )   417 - 441   2015.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

    Despite extensive research efforts over decades, the teratogenic profile of valproic acid (VPA) remains obscure. We performed cumulative and conventional meta-analyses of cohort studies to determine the time profiles of signal emergence of VPA-associated congenital malformations (CMs) and to define risk estimates of each of the CMs. Fifty-nine studies were identified and analyzed. We found that the significant risk signals began to emerge over the last 10-20 years even before large-scale studies were performed: neural tube defect (the significant risk signal emerged in 1992); genitourinary and musculoskeletal anomalies (2004); cleft lip and/or palate (2005); and congenital heart defects (2006). At present, the risks of VPA-associated CMs are 2-7-fold higher than other common antiepileptic drugs. VPA should not be used as a first-line therapy in women of childbearing age unless it is the only option for the patient.

    DOI： 10.1002/cpt.158

    Web of Science

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  • ヒトゲノム・遺伝子解析研究で意図せず見出された遺伝学的個人情報,遺伝子異常の扱い

    OBORI SACHIKO, HIRAHARA FUMIKI, YAMAGUCHI MIZUHO, HAMANOUE HARUKA, KATO HIDEAKI, MIYATAKE SATOKO, TANOSHIMA MIKI, OKUDA MIKA, SAWAI KAORI

    日本遺伝カウンセリング学会誌   32 ( 2 )   94   2011.5

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    Language：Japanese  

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MISC

  • 当院における妊娠初期コンバインド検査の現況

    尾堀佐知子, 浜之上はるか, 浜之上はるか, 山本ゆり子, 須郷慶信, 田野島美城, 宮武聡子, 佐々木元子, 望月昭彦, 長瀬寛美, 鈴木理絵, 沢井かおり, 石川浩史, 平原史樹, 平原史樹, 伊藤秀一

    日本遺伝カウンセリング学会誌   38 ( 2 )   85   2017.5

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  • 当院における無侵襲的出生前遺伝学的検査(NIPT)で判定保留となった症例の転帰

    佐々木元子, 浜之上はるか, 浜之上はるか, 須郷慶信, 尾堀佐知子, 宮武聡子, 田野島美城, 石川浩史, 鈴木理絵, 沢井かおり, 望月昭彦, 長瀬寛美, 平原史樹, 平原史樹, 伊藤秀一

    日本遺伝カウンセリング学会誌   38 ( 2 )   137   2017.5

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  • 当院における出生前遺伝学的検査と遺伝カウンセリングの現状について

    佐々木元子, 浜之上はるか, 浜之上はるか, 須郷慶信, 尾堀佐知子, 田野島美城, 伊藤秀一

    日本遺伝子診療学会大会プログラム・抄録集   24th   59   2017

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  • 子宮頸部嚢胞状腺筋症合併妊娠の一例

    SAITO KEISUKE, IJUIN MASAFUMI, MOCHIMARU AYA, TANOSHIMA MIKI, OGAWA MIYUKI, HIRAHARA FUMIKI

    日本周産期・新生児医学会雑誌   51 ( 2 )   865   2015.6

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  • 当院における出生前遺伝学的検査に関する遺伝カウンセリングの現状と課題

    HAMANOUE HARUKA, TANOSHIMA MIKI, ISHIKAWA HIROSHI, SUGO YOSHINOBU, NAGASE HIROMI, SAWAI KAORI, HOTTA YUICHIRO, KOSHIMIZU NAHO, FURUGOORI MEGUMI, HIRAHARA FUMIKI

    日本遺伝カウンセリング学会誌   36 ( 2 )   97   2015.5

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  • RISKS OF CONGENITAL MALFORMATIONS IN OFFSPRING EXPOSED TO VALPROIC ACID IN UTERO: A SYSTEMATIC REVIEW AND CUMULATIVE META-ANALYSIS.

    T. Kobayashi, M. Tanoshima, R. Tanoshima, J. Beyene, G. Koren, S. Ito

    CLINICAL PHARMACOLOGY & THERAPEUTICS   97   S99 - S100   2015.2

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：WILEY-BLACKWELL  

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  • 妊娠中に発症し化学療法を行った急性白血病合併妊娠の二例

    KITAGAWA MASAKAZU, UEDA REIKO, KAWANO AIKO, ISHIDERA YUMI, FURUNO ATSUKO, OBORI SACHIKO, YAMAGUCHI MIZUHO, TANOSHIMA MIKI, NAGASE HIROMI, IHATA YUTAKA, OGAWA MIYUKI, SAITO KEISUKE, OKUDA MIKA, TAKAHASHI TSUNEO, KUWAHARA HIDEYUKI, HIRAHARA FUMIKI

    関東連合産科婦人科学会誌   49 ( 4 )   601 - 608   2012.11

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  • 妊娠23週に若年性脳梗塞を発症した1例

    SUE EIKO, MATSUZAKI YUKARI, IMAI KAZUAKI, TAKEUCHI AZUSA, NARA AKIKO, TOKINAGA AYA, KATO SAE, YAMAGUCHI MIZUHO, MOCHIZUKI AKIHIKO, TANOSHIMA MIKI, KURASAWA KENTARO, AOKI SHIGERU, OKUDA MIKA, TAKAHASHI TSUNEO, HIRAHARA FUMIKI

    日本産科婦人科学会神奈川地方部会会誌   48 ( 2 )   107   2012.1

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  • 2009年度産科救急報告

    ISHIKAWA HIROSHI, ISHIYAMA MEGUMI, IZUCHI SHIN'ICHIRO, ISHIZUKA BUMPEI, NAKO TAKAFUMI, SAITO JUICHIRO, TANOSHIMA MIKI, OKUDA MIKA, TAKAHASHI TSUNEO, KATO YOSHIKI, KONDO AKANE, ISHIMOTO HITOSHI, MOCHIZUKI JUNKO, AMANO KAN, UNNO NOBUYA, HIRABUKI TOMOO

    日本産科婦人科学会神奈川地方部会会誌   48 ( 1 )   9 - 12   2011.7

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  • 胎児期より管理した脊椎骨端異形成症の一母子例

    IWATA AKIKO, OKUDA MIKA, YAMAGUCHI MIZUHO, MOCHIZUKI AKIHIKO, KURASAWA KENTARO, TANOSHIMA MIKI, OGAWA SACHI, HORIGUCHI HARUKO, SEKI KAZUO, TAKAHASHI TSUNEO, HIRAHARA FUMIKI

    日本先天異常学会学術集会プログラム・抄録集   51st   89   2011.7

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  • 反復した嵌頓子宮の1例

    TAKEUCHI AZUSA, OKUDA MIKA, KATO SAE, TOKINAGA AYA, YAMAGUCHI MIZUHO, MOCHIZUKI AKIHIKO, KURASAWA KENTARO, TANOSHIMA MIKI, SEKI KAZUO, TAKAHASHI TSUNEO, HIRAHARA FUMIKI

    日本周産期・新生児医学会雑誌   47 ( 2 )   451   2011.6

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  • 三絨毛膜三胎の一児に完全大血管転位症を認め,出生後に先天性食道閉鎖症合併が判明した1例

    MOCHIZUKI AKIHIKO, KATO SAE, TOKINAGA AYA, YAMAGUCHI MIZUHO, KURASAWA KENTARO, TANOSHIMA MIKI, OKUDA MIKA, MARUYAMA YASUYO, NISHIMAKI SHIGERU, SEKI KAZUO, TAKAHASHI TSUNEO, HIRAHARA FUMIKI

    日本周産期・新生児医学会雑誌   47 ( 2 )   427   2011.6

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  • 満期の前期破水(PROM)に対する分娩誘発方法の選択について

    KURASAWA KENTARO, KATO SAE, MOCHIMARU AYA, YAMAGUCHI MIZUHO, MOCHIZUKI AKIHIKO, TANOSHIMA MIKI, OKUDA MIKA, TAKAHASHI TSUNEO, HIRAHARA FUMIKI

    日本周産期・新生児医学会雑誌   47 ( 2 )   407   2011.6

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  • 出生体重500g未満の超低出生体重児の検討~母体胎児管理の検討~

    OKUDA MIKA, HORIGUCHI HARUKO, KATO SAE, YAMAGUCHI MIZUHO, MOCHIZUKI AKIHIKO, KURASAWA KENTARO, TANOSHIMA MIKI, SATO MIHO, AN HIROMI, SEKI KAZUO, TAKAHASHI TSUNEO, HIRAHARA FUMIKI

    日本周産期・新生児医学会雑誌   47 ( 2 )   567   2011.6

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