Updated on 2025/06/03

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写真a

 
Ryoko Asano
 
Organization
YCU Medical Center Gynecology Associate Professor
Title
Associate Professor
Profile
子宮筋腫は多くの女性を悩ます疾患です。子宮筋腫自体が産生するエリスロポエチンが子宮筋腫増大に及ぼす影響を解明し、新たな分子標的療法の開発を目指して研究しています。
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Degree

  • 博士（医学） ( 横浜市立大学 )

Research Interests

  • 更年期

  • 分子生物学

  • Laparoscopic Surgery

  • 骨粗鬆症

  • Reproductive Endocrinology

  • Endometriosis

  • Uterine Leiomyoma

  • Obstetrics and Gynecology

Research Areas

  • Life Science / Tumor diagnostics and therapeutics

  • Life Science / Obstetrics and gynecology

Education

  • Yokohama City University   Graduate School of Medicine

    2013.4 - 2017.3

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  • Yokohama City University   School of Medicine

    2000.4 - 2006.3

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Research History

  • 横浜市立大学附属 市民総合医療センター 婦人科 講師/部長代理

    2022.4

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  • 横浜市立大学附属 市民総合医療センター   婦人科   助教

    2021.4 - 2022.3

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  • 横浜市立市民病院   産婦人科   医長

    2020.4 - 2021.3

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  • Yokohama City University School of Medicine Medical Course , Obsterics and Gynecology   Visiting Researcher

    2019.4 - 2021.3

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  • Yokohama Municipal Citizen's Hospital   Department of Obstetrics and Gynecology

    2019.4 - 2020.3

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  • Yokohama City University, Graduate School of Medicine   Department of Obstetrics, Gynecology, and Molecular Reproductive Science   Assistant Professor

    2017.4 - 2019.3

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  • 神奈川県立がんセンター   臨床研究所   研修生

    2016.3 - 2020.3

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  • Yokohama City University, Graduate School of Medicine   Department of Obstetrics, Gynecology, and Molecular Reproductive Science   Graduate student

    2013.4 - 2017.3

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  • Yokohama Minami Kyousai Hospital   Department of Obstetrics and Gynecology   Doctor

    2011.4 - 2013.3

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  • Yokohama City University Hospital   Department of Obstetrics and Gynecology   Senior resident

    2008.4 - 2011.3

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  • Yokohama City University Hospital   Junior resident

    2006.4 - 2008.3

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Professional Memberships

  • JAPAN SOCIETY OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY AND MINIMALLY INVASIVE THERAPY

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  • JAPAN SOCIETY OF OBSTETRICS AND GYNECOLOGY

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  • The Japan Endocrine Society

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  • Endocrine Society

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  • 日本臨床細胞診学会

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  • THE JAPAN SOCIETY FOR MENOPAUSE AND WOMEN'S HEALTH

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Papers

  • Effect of bisphosphonate and denosumab treatment on TBS in Japanese breast cancer patients with AIBL.

    Emi Onuma, Shin Saito, Taku Tsuburai, Hiromi Yoshikata, Shoko Adachi, Shinya Yamamoto, Kazutaka Narui, Tomonari Hayama, Mariko Murase, Taichi Mizushima, Etsuko Miyagi, Hideya Sakakibara, Ryoko Asano

    Journal of bone and mineral metabolism   2024.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Bisphosphonates and denosumab increase bone mineral density (BMD) for osteoporosis treatment in patients with aromatase inhibitor-associated bone loss (AIBL). This study aimed to directly compare bisphosphonates with denosumab in treating patients with AIBL and to determine the effect of denosumab on the trabecular bone score (TBS). MATERIALS AND METHODS: Thirty-nine patients with AIBL receiving osteoporosis treatment (21 in the bisphosphonates group and 18 in the denosumab group) were retrospectively evaluated for changes in lumbar spine and femoral BMD, lumbar spine bone quality (assessed by TBS), and blood bone metabolic markers. The Mann-Whitney and Wilcoxon tests were used for statistical evaluation. RESULTS: After 24 months of treatment, the lumbar spine BMD change rate was 5.82 ± 1.10% with bisphosphonates and 10.49 ± 1.20% with denosumab, with the change rate of denosumab significantly increasing over that of bisphosphonates. The change rate in femoral BMD was 2.69 ± 1.16% with bisphosphonates and 2.95 ± 1.26% with denosumab, with no significant difference between the two groups. The rate of decrease in tartrate-resistant acid phosphatase isoform 5b was significantly higher in the denosumab group. The change rate in TBS at 24 months of treatment was 0.53 ± 1.26% in the bisphosphonates group and 1.08 ± 1.33% in the denosumab group, with no significant difference between the two groups. After 24 months, TBS remained stable. CONCLUSION: Both bisphosphonates and denosumab may increase BMD, improve bone metabolism, and inhibit bone quality loss in patients with AIBL.

    DOI： 10.1007/s00774-024-01542-2

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  • 子宮筋腫におけるMED12遺伝子変異とCyclin-dependent kinase 8(CDK8)活性の関連

    谷岡 沙紀, 浅野 涼子, 永井 康一, 村田 千恵, 平原 裕也, 有野 祐子, 岩泉 しず葉, 宮城 悦子

    日本産科婦人科学会雑誌   76 ( 臨増 )   S - 368   2024.2

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    Language：Japanese   Publisher：(公社)日本産科婦人科学会  

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  • MED12 mutations in uterine leiomyomas: prediction of volume reduction by gonadotropin-releasing hormone agonists. International journal

    Koichi Nagai, Ryoko Asano, Futoshi Sekiguchi, Mikiko Asai-Sato, Yohei Miyagi, Etsuko Miyagi

    American journal of obstetrics and gynecology   228 ( 2 )   207.e1-207.e9   2022.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Gonadotropin-releasing hormone agonists are used to treat premenopausal uterine leiomyomas; however, leiomyoma volume reduction is not always achieved. The reduction rate after this treatment varies for each leiomyoma, even in the same patient. Therefore, an effective method for predicting uterine leiomyoma volume reduction is required to reduce the adverse hypoestrogenic effects and drug-related economic burden related to gonadotropin-releasing hormone agonists. OBJECTIVE: We aimed to determine the predictive utility of MED12 mutations for evaluating the effect of gonadotropin-releasing hormone agonist treatment with respect to reducing uterine leiomyoma volume and to predict the MED12 mutation status based on the findings of magnetic resonance imaging performed before treatment. STUDY DESIGN: MED12 exon 2 mutation and erythropoietin expression in uterine leiomyomas were evaluated in relation to volume reduction, as measured using magnetic resonance imaging. We developed a system for classifying leiomyomas according to T2-weighted magnetic resonance imaging signals to non-invasively predict the presence or absence of MED12 mutations in leiomyomas. Leiomyoma samples (>5 cm) were obtained from 168 patients during surgery (hysterectomy or myomectomy) between 2005 and 2021 at Yokohama City University Hospital. To analyze the rate of leiomyoma volume reduction, 41 patients had been preoperatively administered the gonadotropin-releasing hormone agonist (leuprorelin acetate 3.75 mg, monthly subcutaneous injection) for 3 months; magnetic resonance imaging was performed before and after treatment without contrast material. RESULTS: Compared to leiomyomas expressing wild-type MED12 exon 2, those with MED12 exon 2 mutations were less likely to have reduced volume following treatment with the gonadotropin-releasing hormone agonist (P<.001, Mann-Whitney U test) and displayed lower signal intensity on T2-weighted images. The newly proposed magnetic resonance imaging-based classification system showed that MED12 exon 2 mutations were more frequent in the low-signal group than in the high-signal group, with nearly equal proportions of mutated and wild-type MED12 exon 2 leiomyomas noted in the intermediate group. The low-signal group had significantly lower erythropoietin expression levels than the high-signal group (P<.001, Kruskal-Wallis test with Dunn's post hoc analysis). CONCLUSIONS: MED12 mutation status can be a candidate marker for predicting the effect of gonadotropin-releasing hormone agonists on uterine leiomyoma reduction. Magnetic resonance imaging findings can be used to determine MED12 mutation status as a noninvasive strategy to select patients who will most likely benefit from gonadotropin-releasing hormone agonist treatment.

    DOI： 10.1016/j.ajog.2022.09.024

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  • Evaluating the safety of dienogest in women with adenomyosis: A retrospective analysis. International journal

    Natsumi Ono, Ryoko Asano, Koichi Nagai, Yoshinobu Sugo, Tomomi Nakamura, Etsuko Miyagi

    The journal of obstetrics and gynaecology research   47 ( 4 )   1433 - 1440   2021.4

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    AIM: Dienogest (DNG) is highly effective for relieving pain caused by endometriosis and adenomyosis. However, women with severe uterine swelling due to adenomyosis who take DNG usually experience metrorrhagia. This study aimed to examine the safety of DNG usage in women with adenomyosis. METHODS: This study included 20 women who were prescribed DNG for adenomyosis in our hospital from January 2016 to December 2016. We retrospectively analyzed women's clinical background characteristics (age, the use of the gonadotropin-releasing hormone agonist as pre-treatment of DNG, the uterus size [major axis, minor axis, maximum thickness in the myometrium, and length of the uterine body] by transvaginal ultrasonography [TVUS], hemoglobin level, and the presence of metrorrhagia during treatment). These variables were compared between the DNG continuation and discontinuation groups using the Mann-Whitney U test. RESULTS: Thirteen women continued DNG, and seven discontinued DNG within 12 months because of metrorrhagia. The uterine size was significantly larger in the discontinuation group than in the continuation group. All uterine measurements had high Spearman rank correlation coefficients (ρ > 0.8, P < 0.05). In six of seven cases in the discontinuation group, adenomyosis was in the anterior wall. Measuring the uterus size and locating adenomyosis by TVUS are simple methods of predicting DNG discontinuation. CONCLUSION: We consider that DNG can be safely administered in women with adenomyosis if the uterine size is <6 cm in the minor axis and the main lesion of adenomyosis is located in the posterior uterine wall.

    DOI： 10.1111/jog.14612

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  • Pretreatment maximum standardized uptake value in 18F-fluorodeoxyglucose positron emission tomography-computed tomography as a prognostic factor for ovarian clear cell carcinoma and low-grade serous carcinoma. International journal

    Takuto Matsuura, Isao Otsuka, Toshihiro Ouchi, Eri Ouchi, Ryoko Asano, Naoyuki Miyasaka

    Taiwanese journal of obstetrics & gynecology   60 ( 2 )   305 - 310   2021.3

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    OBJECTIVE: The maximum standardized uptake value (SUVmax) derived by positron emission tomography-computed tomography (PET/CT) can be an index of biological tumor aggressiveness, which is assessed using noninvasive tools before the treatment of epithelial ovarian cancer (EOC). This study aimed to evaluate the prognostic value of the pretreatment SUVmax in patients with EOC. MATERIALS AND METHODS: We reviewed the data of patients with EOC who underwent pretreatment 18F-FDG PET/CT between June 2006 and September 2016. The relationships between pretreatment SUVmax and histological subtypes of EOC were determined. Moreover, progression-free survival (PFS) and overall survival (OS) were evaluated according to the pretreatment SUVmax. Risk factors associated with progression or death were also analyzed. RESULTS: Of 148 patients, 66 (44.6%), 11 (7.4%), 34 (23.0%), 19 (12.8%), 15 (10.1%), and three (2.0%) were diagnosed with high-grade serous carcinoma (HGSC), low-grade serous carcinoma (LGSC), clear cell carcinoma (CCC), endometrioid carcinoma, mucinous carcinoma, and others, respectively. The median SUVmax was marginally lower in LGSC (6.80 vs. 10.5; P = 0.059) and significantly lower in CCC (5.92 vs. 10.5; P = 0.001) than in HGSC. A high pretreatment SUVmax (≥9.30) was a prognostic factor for OS in patients with LGSC (P = 0.046). Furthermore, multivariate analysis revealed that a high SUVmax (≥5.85) was an independent prognostic factor for OS (P = 0.046) in patients with CCC. However, a high SUVmax (≥7.77) was a poor predictor of PFS and OS in patients with EOC (P = 0.156 and P = 0.158, respectively). CONCLUSION: Our findings suggest that the pretreatment SUVmax is not only an independent predictor of survival in patients with CCC but also a significant predictor of survival in patients with LGSC.

    DOI： 10.1016/j.tjog.2021.01.009

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  • 浸潤癌として再発した卵巣粘液性境界悪性腫瘍I期の3例

    佐野 真奈美, 古郡 恵, 櫻井 静, 山口 尚子, 谷岡 沙紀, 濱田 春, 牛尾 江実子, 石川 玲奈, 村田 千恵, 堀田 裕一朗, 近藤 真哉, 浅野 涼子, 吉田 浩, 安藤 紀子, 茂田 博行

    神奈川産科婦人科学会誌   57 ( 2 )   186 - 186   2021.3

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    Language：Japanese   Publisher：神奈川産科婦人科学会  

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  • ダグラス窩より後腟円蓋に発達した子宮内膜症病変より多量出血した1例

    澤井 瑞穂, 浅野 涼子, 古郡 恵, 櫻井 静, 山口 尚子, 谷岡 沙紀, 濱田 春, 牛尾 江実子, 石川 玲奈, 村田 千恵, 堀田 裕一朗, 近藤 真哉, 吉田 浩, 安藤 紀子, 茂田 博行

    神奈川産科婦人科学会誌   57 ( 2 )   184 - 184   2021.3

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  • 不妊を合併し,治療に苦慮した膀胱子宮内膜症の1例

    岡田悠暉, 中村朋美, 柊一哉, 永井康一, 浅野涼子, 須郷慶信, 倉澤健太郎, 宮城悦子

    神奈川産科婦人科学会誌   56 ( 1 )   37 - 41   2019.10

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    Language：Japanese  

    J-GLOBAL

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  • 緊急手術を要した早期型トロッカーサイトヘルニアの3例 Reviewed

    紙谷 菜津子, 鈴木 幸雄, 齊藤 真, 浅野 涼子, ルイズ横田 奈朋, 松永 竜也, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌   35 ( 1 )   138 - 143   2019.4

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    症例1は55歳女性で、両側卵巣腫瘍(成熟嚢胞性奇形腫と漿液性嚢胞腺腫)に対し腹腔鏡下両側付属器摘出術を施行した。術後16日より嘔気を認め、術後25日に造影CTで左下腹部の12mmトロッカー創部にトロッカーサイトヘルニア(TSH)を認めた。ヘルニアの嵌頓と癒着による閉塞性イレウスを認め、緊急に小開腹下にヘルニアを解除した。症例2は45歳女性で、多発子宮筋腫に対し全腹腔鏡下子宮全摘出術を施行した。術直後より嘔気を認め、術後3日にCTで左下腹部の12mmトロッカー創部にTSHを認めた。緊急に小開腹下にヘルニアを解除した。症例3は65歳女性で、子宮体癌IA期(類内膜癌G1)に対し全腹腔鏡下準広汎子宮全摘術を施行した。術直後より嘔気を認め、術後10日に造影CTで右下腹部の5mmトロッカー創部にTSHを認めた。腹腔鏡下にヘルニア解除を試みたが、周囲との癒着が強固で、小切開下にヘルニア解除と小腸部分切除術を行った。

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  • 緊急手術を要した早期型トロッカーサイトヘルニアの3例

    紙谷 菜津子, 鈴木 幸雄, 齊藤 真, 浅野 涼子, ルイズ横田 奈朋, 松永 竜也, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌   35 ( 1 )   138 - 143   2019.4

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  • Expression of erythropoietin messenger ribonucleic acid in wild-type MED12 uterine leiomyomas under estrogenic influence: new insights into related growth disparities. Reviewed International journal

    Asano R, Asai-Sato M, Matsukuma S, Mizushima T, Taguri M, Yoshihara M, Inada M, Fukui A, Suzuki Y, Miyagi Y, Miyagi E

    Fertility and sterility   111 ( 1 )   178 - 185   2019.1

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    OBJECTIVE: To determine factors that impact erythropoietin (EPO) production in leiomyomas. We have previously implicated EPO production in promoting the growth of some leiomyomas. DESIGN: The relationship between EPO messenger RNA (mRNA) expression and MED12 gene mutations or mRNA expression levels of high-mobility group AT-hook (HMGA) 1 and HMGA2 were analyzed. Effects of 10-8 M 17β-E2 on EPO mRNA expression were evaluated using leiomyoma cells grown in primary cultures. SETTING: Graduate school of medicine. PATIENT(S): Patients with leiomyoma. INTERVENTION(S): We used tissue samples and clinical data of 108 patients with leiomyomas to analyze the relation between EPO mRNA expression and MED12 mutation. Tissue samples from another 10 patients with leiomyomas were collected for in vitro experimentation using primary cultures of leiomyoma and myometrial cells. MAIN OUTCOME MEASURE(S): Relations between EPO mRNA expression, MED12 exon 2 mutation, and HMGA1/HMGA2 mRNA expression levels in leiomyoma samplings, in addition to effects of estrogen (E) on EPO mRNA expression in cultures of leiomyoma cells. RESULT(S): The EPO mRNA level was threefold higher in leiomyomas with wild-type (vs. mutated) MED12 genes. There was no correlation between EPO and HMGA1 or HMGA2 mRNA expression levels. In wild-type MED12 leiomyomas only, E2 treatment produced a twofold increase in EPO mRNA expression, whereas mutated MED12 leiomyomas were unaffected. CONCLUSION(S): The EPO mRNA expression increased significantly after E2 treatment only in leiomyomas lacking MED12 mutations. In conjunction with prior evidence linking EPO mRNA expression levels and tumor size, E2-stimulated EPO mRNA expression may explain the marked growth disparities seen in these tumors.

    DOI： 10.1016/j.fertnstert.2018.09.014

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  • 当院における骨粗鬆症に対するゾレドロン酸注射製剤の検討

    須郷 慶信, 倉澤 健太郎, 中口 芳恵, 小田上 瑞葉, 浅野 涼子, 尾堀 佐知子, 中村 朋美, 善方 裕美, 菊地 律子, 宮城 悦子

    日本女性医学学会雑誌   26 ( Suppl. )   160 - 160   2018.10

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  • 乳房痛を認めた上皮性卵巣腫瘍の1例

    窪田 葵, 須郷 慶信, 立花 貴彦, 大野 菜, 紙谷 菜津子, 小田上 瑞葉, 齊藤 真, 浅野 涼子, 尾堀 佐知子, 倉澤 健太郎, 中村 朋美, 宮城 悦子

    神奈川産科婦人科学会誌   55 ( 1 )   81 - 81   2018.9

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  • 乳房痛を認めた上皮性卵巣腫瘍の1例

    窪田 葵, 須郷 慶信, 立花 貴彦, 大野 菜, 紙谷 菜津子, 小田上 瑞葉, 齊藤 真, 浅野 涼子, 尾堀 佐知子, 倉澤 健太郎, 中村 朋美, 宮城 悦子

    神奈川医学会雑誌   45 ( 2 )   194 - 195   2018.7

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  • Magnetic Resonance Imaging Grading System for Preoperative Diagnosis of Leiomyomas and Uterine Smooth Muscle Tumors Reviewed

    Yukio Suzuki, Shinichiro Wada, Ayako Nakajima, Yoshiyuki Fukushi, Masaru Hayashi, Takuma Matsuda, Ryoko Asano, Yasuo Sakurai, Hiroko Noguchi, Toshiya Shinohara, Chikara Sato, Takafumi Fujino

    Journal of Minimally Invasive Gynecology   25 ( 3 )   507 - 513   2018.3

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier B.V.  

    Study Objective: To evaluate a new magnetic resonance imaging (MRI) grading system for preoperative differentiation between benign and variant-type uterine leiomyomas including smooth muscle tumors of uncertain malignant potential (STUMPs). Design: Retrospective analysis (Canadian Task Force classification III). Setting: Teaching hospital (Teine Keijinkai Hospital). Patients: Three-hundred thirteen patient medical records were retrospectively reviewed if treated for uterine myomas and diagnosed with variant type leiomyomas or STUMPs (n = 27) or benign, typical leiomyomas (n = 286) and treated between January 2012 and December 2014. Intervention: Uterine myoma classifications using MRI findings according to a 5-grade system (grades I–V) based on 3 elements. Measurements and Main Results: Uterine myoma MRI classifications were based on 3 elements: T2-weighted imaging (high or low), diffusion-weighted imaging (high or low), and apparent diffusion coefficient values (high or low
    apparent diffusion coefficient &lt
    1.5 × 10−3 mm2/sec was considered low). Grades I to II were designated as typical or benign leiomyomas, grade III as degenerated leiomyomas, and grades IV to V as variant type leiomyomas or STUMPs. Accuracy levels were 98.9%, 100%, 94.3%, 58.8%, and 41.9% for grades I through V lesions, respectively. The grades were divided into 2 groups to discriminate benign leiomyomas and STUMPs (grades I–III were considered negative and grades IV–V positive). Grades IV to V scored 85.2% for sensitivity, 91.3% for specificity, 47.9% positive predictive value, 98.5% negative predictive value, a 9.745 positive likelihood ratio, and a.162 negative likelihood ratio. Conclusion: This novel MRI grading system for uterine myomas may be beneficial in differentiating benign leiomyomas from STUMPs or variant type leiomyomas and could be a future effective presurgical assessment tool.

    DOI： 10.1016/j.jmig.2017.08.660

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  • Massive Subcutaneous Emphysema Extending to the Face during Total Laparoscopic Hysterectomy. Reviewed

    Asano R, Suzuki Y, Saito S, Kamiya N, Aoki M, Miyagi E

    J Minim Invasive Gynecol   Epub ahead of print   2018

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  • Evaluation of the safety of total laparoscopic modified radical hysterectomy and the problems of technical standardization in our hospital

    Saito Shin, Miyagi Etsuko, Matsunaga Tatsuya, Kamiya Natsuko, Ota Yukihide, Suzuki Yukio, Asano Ryoko, Imai Yuichi, Ruiz Naho, Nakamura Tomomi

    JAPANESE JOURNAL OF GYNECOLOGIC AND OBSTETRIC ENDOSCOPY   34 ( 2 )   178 - 183   2018

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    Language：Japanese   Publisher：日本産科婦人科内視鏡学会  

    &lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; Since 2014, we changed the surgical procedure for treatment of early stage endometrial cancer from modified radical hysterectomy (mRH) to total laparoscopic modified radical hysterectomy (TLmRH). When provided with training, even gynecologists with little experience in laparoscopic surgery can perform this procedure. In this study, we compared the results of laparoscopic surgery and laparotomy for treatment of endometrial cancer, further analyzed the results of laparoscopic surgery when performed by each surgeon.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Patients: &lt;/b&gt;Eighty-seven cases diagnosed with endometrial cancer stage IA before surgery were examined. Fifty-two TLmRH cases (group A), and 35 mRH cases (group B) were compared. Group A was classified into three groups (C: 16 cases, D: 18, E: 18, respectively) according to the number of total laparoscopic hysterectomy operations.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; In group A, the operation time was significantly longer, bleeding volume was lesser, and hospital stays were shorter than in group B. There was no recurrence in either group. Surgical results among the three groups (C, D, and E) were compared. The operation time for the cases in group E with a small number of surgeries was long and the complications tended to be more in number.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; Subjects who underwent laparoscopic surgery showed reduced bleeding volume, shortened hospitalization period, and early recovery. On short-term observation, recurrence was not noted, and the same results as laparotomy surgery were obtained. However, complications associated with low proficiency level were recognized. In laparoscopic surgery, it is desirable not only to acquire the skills, but also undergo training before performing the surgery.&lt;/p&gt;

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  • Expression of erythropoietin mRNA in wild-type MED12 uterine leiomyomas under estrogenic influence: new insights into related growth disparities Reviewed

    Asano R, Asai-Sato M, Matsukuma S, Mizushima T, Taguri M, Yoshihara M, Inada M, Fukui A, Suzuki Y, Miyagi Y, Miyagi E

    Fertil Steril   In press   2018

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  • Teriparatide and denosumab treatment for pregnancy and lactation-associated osteoporosis with multiple vertebral fractures: A case study Reviewed

    Akifumi Ijuin, Hiromi Yoshikata, Ryoko Asano, Taku Tsuburai, Ritsuko Kikuchi, Hideya Sakakibara

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   56 ( 6 )   863 - 866   2017.12

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    Objective: Pregnancy and lactation-associated osteoporosis (PLO) is a rare disease, which can lead to vertebral fractures in women of reproductive age. No treatment strategy for PLO has been established. Here we report a case of PLO treated with teriparatide followed by denosumab, in which remarkable improvement in bone mineral density (BMD) was achieved.
    Case report: A 27-year-old woman experienced severe back pain two weeks after her first delivery. PLO was diagnosed from her low BMD and multiple vertebral compression fractures. She was treated with teriparatide for 6 months, followed by denosumab. After 1 year, her BMD increase from baseline was 16.5% in L2-4 and her pain had been relieved.
    Conclusion: In addition to weaning, administration of teriparatide followed by denosumab led to remarkable improvement in the patient's symptoms and BMD. Therefore, we regard this method as a promising choice for the treatment of PLO. (C) 2017 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.

    DOI： 10.1016/j.tjog.2017.10.028

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  • 子宮頸癌からの多量性器出血に対する子宮動脈塞栓術後にヘパリン起因性血小板減少症を来した一例

    大野 菜, 浅野 涼子, 太田 幸秀, 今井 雄一, 須郷 慶信, ルイズ横田 奈朋, 松永 竜也, 佐藤 美紀子, 宮城 悦子

    関東連合産科婦人科学会誌   54 ( 3 )   308 - 308   2017.10

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  • Accuracy of self-collected human papillomavirus samples from Japanese women with abnormal cervical cytology Reviewed

    Kawano-Yashiro Aiko, Motoki Yoko, Oba Mari Saito, Asano Ryoko, Maruyama Yasuyo, Asai-Sato Mikiko, Yamanaka Takeharu, Hirahara Fumiki, Miyagi Etsuko

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   43 ( 4 )   710 - 717   2017.4

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    AimThe aim of this study was to assess the accuracy of self-collected vaginal samples compared with physician-collected cervical samples for high-risk human papillomavirus (HPV) testing in Japanese women with abnormal cervical cytology. We also assessed the acceptability of self-collected HPV (sHPV) testing using a questionnaire.
    MethodsWomen aged 20-69 years (n = 136) attending Yokohama City University Hospital because of abnormal cervical cytology between April 2014 and January 2015 were enrolled in this study. Cervical samples for conventional cytology and physician-collected HPV (pHPV) testing were obtained before colposcopic examination. After this examination, patients were asked to provide a self-sampled vaginal specimen (sHPV) at home, some time between the following day and the next week and to complete a self-sampling acceptability questionnaire.
    ResultsThe overall positive rates of HPV detection with pHPV and sHPV testing were 61.0% (83/136) and 40.4% (55/136), respectively (P &lt; 0.001). sHPV testing had a lower sensitivity compared to pHPV for detection of cervical intraepithelial neoplasia (CIN)2 or worse (CIN2+: 59.4% vs 100%, P &lt; 0.001; CIN3: 66.7% vs 100%, P = 0.248). There were no statistically significant differences in the sensitivity to detect CIN3 among pHPV testing, sHPV testing, and cytology. The self-collecting device had good acceptability.
    ConclusionsHPV testing is a possible technique with which to improve poor cervical cancer screening uptake rates in Japan; however, the sensitivity to detect CIN2+ lesions must improve before it can be a substitute for conventional cytology or pHPV testing. Further large-scale acceptability studies involving non-responders are needed before practical application.

    DOI： 10.1111/jog.13258

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  • Estrogen increases erythropoietin mRNA expression in uterine leiomyoma: a novel role of estrogen in uterine smooth muscle tumor

    R. Asano, M. Asai-Sato, Y. Miyagi, E. Miyagi

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   26   215 - 215   2016.10

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  • An adolescent case of obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome presenting with dysmenorrhea Reviewed

    53 ( 1 )   2 - 5   2016.9

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  • Aberrant Expression of the Cell Polarity Regulator aPKC lambda/iota is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis Reviewed

    Taichi Mizushima, Mikiko Asai-Sato, Kazunori Akimoto, Yoji Nagashima, Masataka Taguri, Kazunori Sasaki, Masa-aki Nakaya, Ryoko Asano, Aya Tokinaga, Tohru Kiyono, Fumiki Hirahara, Shigeo Ohno, Etsuko Miyagi

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY   35 ( 2 )   106 - 117   2016.3

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    Atypical protein kinase C lambda/iota (aPKC lambda/iota) is a regulator of epithelial cellular polarity. It is also overexpressed in several cancers and functions in cell proliferation and invasion. Therefore, we hypothesized that aPKC lambda/iota may be involved in development and progression of cervical intraepithelial neoplasia (CIN), the precancerous disease of cervical cancer induced by human papillomavirus. To do this, we investigated the relationship between aPKC lambda/iota expression and CIN. aPKC lambda/iota expression level and subcellular localization were assessed in 192 CIN biopsy samples and 13 normal epithelial samples using immunohistochemistry. aPKC lambda/iota overexpression (normal epithelium, 7.7%; CIN1, 41.7%; CIN2/3, 76.4%) and aPKC lambda/iota nuclear localization (normal epithelium, 0.0%; CIN1, 36.9%; CIN2/3, 78.7%) were higher in CIN samples than normal samples (P &lt; 0.05), suggesting that CIN grade is related to aPKC lambda/iota overexpression and nuclear localization. Then, 140 CIN cases were retrospectively analyzed for 4-yr cumulative disease progression and regression rates using the Cox proportional hazards model. CIN1 cases with aPKC lambda/iota overexpression or aPKC lambda/iota nuclear localization had a higher progression rate than CIN1 cases with normal aPKC lambda/iota expression levels or cytoplasmic localization (62.5% vs. 9.7% and 63.1% vs. 9.4%, respectively; P &lt; 0.001). Multivariate analysis indicated that human papillomavirus types 16 and 18, aPKC lambda/iota overexpression (hazard ratio=4.26; 95% confidence interval, 1.50-12.1; P=0.007), and aPKC lambda/iota nuclear localization (hazard ratio=3.59; 95% confidence interval, 1.24-10.4; P=0.019) were independent risk factors for CIN1 progression. In conclusion, aPKC lambda/iota could be useful for the therapeutic management of patients with CIN, particularly those with non-human papillomavirus 16/18 types.

    DOI： 10.1097/PGP.0000000000000228

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  • たこつぼ型心筋症により心不全を発症した卵巣腫瘍捻転術後の一例 Reviewed

    伊集院 昌郁, 段 泰行, 浅野 涼子, 飯沼 綾子, 齊藤 真, 北山 玲子, 須郷 慶信, 香川 愛子, 長瀬 寛美, 飛鳥井 邦雄

    関東連合産科婦人科学会誌   52 ( 4 )   585 - 593   2015.11

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    卵巣嚢腫の茎捻転に対して緊急手術を行い,術後たこつぼ型心筋症を発症した症例を経験したので報告する.症例は88歳.突然の下腹部痛を主訴に近医内科を受診し,経腹超音波で下腹部の巨大な嚢腫を認めたため当院紹介受診となった.卵巣嚢腫茎捻転を疑い,緊急開腹手術を行った.18cm大の右卵巣腫瘍が反時計回りに720°捻転しており,右付属器摘出術を施行した.病理組織診断は成人型顆粒膜細胞腫であった.術後1日目に呼吸困難が出現し,酸素化不良となった.胸部X線で肺うっ血があり,心電図異常,心筋逸脱酵素上昇も認めたため心原性の呼吸不全を疑った.心臓カテーテル検査の結果,冠動脈に有意狭窄は認めなかったが,左室造影でEjection Fraction 29%,心尖部の壁運動低下を認め,たこつぼ型心筋症による心不全および呼吸不全と診断された.酸素吸入,human atrial natriuretic peptide(hANP),ヘパリンによる治療と水分コントロールを行ったところ心機能,症状は改善し,術後7日目にhANP,ヘパリンを終了,14日目には酸素吸入を終了した.たこつぼ型心筋症は様々なストレスを契機として発症すると考えられており,産婦人科の周術期においても留意する必要がある.(著者抄録)

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  • Increasing trends in cervical cancer mortality among young Japanese women below the age of 50 years: An analysis using the kanagawa population-based cancer registry, 1975-2012 Reviewed

    Yoko Motoki, Shunsaku Mizushima, Masataka Taguri, Kenzo Takahashi, Ryoko Asano, Hisamori Kato, Mikiko Asai-Sato, Kayoko Katayama, Naoyuki Okamoto, Fumiki Hirahara, Etsuko Miyagi

    CANCER EPIDEMIOLOGY   39 ( 5 )   700 - 706   2015.10

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    Background: In Japan, cervical cancer (CC) deaths among women aged &lt;50 years have doubled over the last three decades. Obtaining age-specific CC mortality rates among young women is important for taking measures against CC. Age-adjusted CC mortality rates for all ages are inadequate because of the classification of 'uterine cancer, not otherwise specified' (NOS uterine cancer) and CC mortality rates among elderly women. The aim of the present study was to calculate exact age-specific CC mortality rates in women aged &lt;50 years in Kanagawa, taking into account the impact of NOS uterine cancer.
    Methods: Using the Kanagawa Cancer Registry, CC deaths (1975-2012) were analyzed and CC mortality rates (age-adjusted, 20-29, 30-49, and &gt;= 50 years) were calculated. In addition, hospitals were surveyed to reclassify cases of NOS uterine cancer. After reclassification, chronological trends were also analyzed.
    Results: Age-specific CC mortality rates in Kanagawa and Japan overall showed increasing trends for ages 20-29 (P for trend &lt; 0.001) and 30-49 (P for trend &lt; 0.001). Rates of NOS uterine cancer death were significantly lower in Kanagawa than in Japan overall (P &lt; 0.05), except for patients aged &lt;50 years in 2005-2009 (P = 0.159).
    Conclusions: The present study revealed concern for CC among Japanese women younger than 50 years. Well-organized CC screening and HPV vaccination should be provided to reduce CC mortality rates for these young women. (C) 2015 Elsevier Ltd. All rights reserved.

    DOI： 10.1016/j.canep.2015.08.001

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  • Aberrant expression of erythropoietin in uterine leiomyoma: implications in tumor growth Reviewed

    Ryoko Asano, Mikiko Asai-Sato, Yohei Miyagi, Taichi Mizushima, Makiko Koyama-Sato, Yoji Nagashima, Masataka Taguri, Hideya Sakakibara, Fumiki Hirahara, Etsuko Miyagi

    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY   213 ( 2 )   199   2015.8

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    OBJECTIVE: Myomatous erythrocytosis syndrome is a rare complication of uterine leiomyoma caused by erythropoietin (EPO) that is produced by tumor cells. We assessed the EPO expression in leiomyomas and investigated the effects of EPO on the tumor growth.
    STUDY DESIGN: Tissue samples were collected from 114 patients with uterine leiomyomas who underwent myomectomy or hysterectomy in Yokohama City University Hospital. From 17 patients, the corresponding normal myometrium was also collected. All samples were analyzed for EPO messenger RNA (mRNA) expression by real-time reverse transcription-polymerase chain reaction. EPO protein expression was determined by an enzyme-linked immunosorbent assay. The relationships between EPO expression and clinicopathological features were retrospectively analyzed using the patients' charts. Blood vessel density and maturity were assessed using hematoxylin-eosin staining and CD34 immunohistochemistry.
    RESULTS: EPO mRNA expression was detected in 108 of 114, or 95%, of the leiomyomas. The mean EPO mRNA expression in the leiomyoma was higher than the corresponding normal myometrium (3836 +/- 4122 vs 1455 +/- 2141; P = .025 by Wilcoxon rank test). The EPO mRNA expression in the leiomyomas varied extensively among samples, ranging from undetectable levels to 18-fold above the mean EPO mRNA of normal myometrium. EPO protein production was observed concomitant with mRNA expression. A positive correlation of leiomyoma size and EPO mRNA expression was shown by Spearman rank correlation coefficient (rho = 0.294; P = .001), suggesting the involvement of EPO in leiomyoma growth. The blood vessel maturity was also significantly increased in EPO-producing leiomyomas (high vessel maturity in high vs low EPO group: 67% vs 20%; P = .013 by Fisher exact test).
    CONCLUSION: This report demonstrates that EPO is produced in most of conventional leiomyomas and supports a model in which EPO accelerates tumor growth, possibly by inducing vessel maturity. Our study suggests one possible mechanism by which some uterine leiomyomas reach a large size, and the understanding of EPO expression patterns in these tumors may be useful for management of the patients with leiomyomas.

    DOI： 10.1016/j.ajog.2015.02.016

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  • Steroid cell tumour, not otherwise specified: Rare case with primary amenorrhoea in a 16-year-old Reviewed

    T. Yokozawa, R. Asano, T. Nakamura, M. Furuya, Y. Nagashima, M. Koyama-Sato, Y. Kanda, F. Hirahara, H. Sakakibara

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   35 ( 8 )   867 - 868   2015

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    DOI： 10.3109/01443615.2015.1022141

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  • Dienogest Was Effective in Treating Hemorrhagic Ascites Caused by Endometriosis: A Case Report Reviewed

    Ryoko Asano, Tsuneo Nakazawa, Fumiki Hirahara, Hideya Sakakibara

    JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY   21 ( 6 )   1110 - 1112   2014.11

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    Hemorrhagic ascites caused by endometriosis is extremely rare, and its treatment is under discussion. We report a case of recurrent endometriosis-related ascites treated with dienogest (DNG). A 35-year-old nulliparous Japanese woman with a history of infertility presented with worsening dysmenorrhea and abdominal distention caused by massive ascites. The patient underwent exploratory laparotomy, and hemorrhagic ascites (5500 mL) was drained. She had a normal-sized uterus, and the bilateral ovaries could not be observed because of extensive adhesion in the abdominal cavity. Endometriosis was diagnosed by histopathological evaluation of the omental biopsy, and this was considered to be the cause of ascites. After laparotomy, she had recurrence of ascites. For the next 8 years, the patient was treated conservatively with gonadotropin-releasing hormone agonist therapy and drainage during the intermittent periods followed by DNG administration. She has been treated continuously with DNG for 1 year with no recurrence of ascites. DNG could be an effective treatment for recurrent ascites associated with endometriosis, especially when surgical therapy is undesirable. (C) 2014 AAGL. All rights reserved.

    DOI： 10.1016/j.jmig.2014.04.014

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  • 産褥期に発症したMRSAによる感染性心内膜炎の1例 Reviewed

    稲垣 萌美, 浅野 涼子, 飯沼 綾子, 加藤 宵子, 永田 亮, 香川 愛子, 長野 研二, 長瀬 寛美, 段 泰行, 飛鳥井 邦雄

    関東連合産科婦人科学会誌   51 ( 1 )   33 - 37   2014.3

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  • A case of metastatic ovarian cancer complicated by Pseudo-Meigs syndrome Reviewed

    50 ( 2 )   138 - 141   2014.1

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    Other Link： http://search.jamas.or.jp/link/ui/2014158388

  • 放射線性腸炎、放射線性膀胱炎に対して、高圧酸素療法を施行した1例 Reviewed

    平田 豪, 石原 瑞葉, 上田 麗子, 佐藤 団, 竹島 和美, 笠井 絢子, 高島 邦僚, 茶木 修, 中山 昌樹, 浅野 涼子, 沼崎 令子, 宮城 悦子, 平原 史樹

    日本産科婦人科学会神奈川地方部会会誌   48 ( 2 )   92 - 94   2012.1

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  • 子宮内膜症再発症例における疼痛の寛解・維持療法としてのジエノゲスト投与に関する検討. Reviewed

    持丸綾, 榊原秀也, 浅野涼子, 北山玲子, 伊藤朋子, 今井雄一, 須郷慶信, 吉崎敦雄, 永田智子, 野村可之, 中村朋美, 平原史樹

    日本エンドメトリオーシス学会会誌   32   150 - 152   2011.7

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  • Treatment of endometriosis in Kanagawa prefecture at present (first report) About dienogest Invited Reviewed

    102 ( 3 )   289 - 294   2011.3

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    Other Link： http://search.jamas.or.jp/link/ui/2011157558

  • 新規骨形成マーカーPINPを用いた骨粗鬆症治療の効果判定 Reviewed

    野村 可之, 附属病院, 産婦人科, 善方 裕美, 田上 裕子, 浅野 涼子, 倉澤 健太郎, 小林 有紀, 住友 和子, 菊地 律子, 榊原 秀也, 茶木 修, 平原 史樹

    Osteoporosis Japan   18 ( 3 )   497 - 501   2010.7

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  • 骨粗鬆症治療薬SERMの有効性 長期投与成績から Reviewed

    善方 裕美, 産婦人科, 茶木 修, 浅野 涼子, 葉山 智工, 野村 可之, 倉澤 健太郎, 小林 有紀, 住友 和子, 菊池 律子, 榊原 秀也, 平原 史樹

    Osteoporosis Japan   18 ( 3 )   489 - 492   2010.7

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  • 骨密度評価から骨折リスク評価へ 婦人科におけるFRAXの臨床応用 FRAXを用いた骨粗鬆症治療の介入ポイントについて 当科における介入ポイントとの比較検討 Reviewed

    野村 可之, 倉澤 健太郎, 磯村 和美, 浅野 涼子, 古野 敦子, 榎本 紀美子, 永田 智子, 斉藤 圭介, 善方 裕美, 菊地 律子, 榊原 秀也, 茶木 修, 平原 史樹

    Osteoporosis Japan   17 ( 3 )   485 - 488   2009.7

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  • 著明な頸部腫大を伴ったB群溶連菌感染による子宮頸管炎の1例 Reviewed

    浅野 涼子, 吉田 浩, 石川 雅彦, 平原 史樹

    日本産科婦人科学会神奈川地方部会会誌   45 ( 2 )   108 - 111   2009.1

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  • 炭酸リチウムによる尿崩症に対しサイアザイド系利尿薬とインドメタシンの併用が有効であった一例 Reviewed

    堀 亜希子, 浅野 涼子, 早坂 俊亮, 大槻 正樹, 長谷川 花, 杉山 直也, 平安 良雄, 小田原 俊成

    神奈川県精神医学会誌   ( 57 )   39 - 42   2008.3

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  • ダグラス窩より後腟円蓋に発達した子宮内膜症病変より多量出血した1例

    澤井 瑞穂, 浅野 涼子, 古郡 恵, 櫻井 静, 山口 尚子, 谷岡 沙紀, 濱田 春, 牛尾 江実子, 石川 玲奈, 村田 千恵, 堀田 裕一朗, 近藤 真哉, 吉田 浩, 安藤 紀子, 茂田 博行

    神奈川医学会雑誌   48 ( 1 )   34 - 34   2021.1

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  • 浸潤癌として再発した卵巣粘液性境界悪性腫瘍I期の3例

    佐野 真奈美, 古郡 恵, 櫻井 静, 山口 尚子, 谷岡 沙紀, 濱田 春, 牛尾 江実子, 石川 玲奈, 村田 千恵, 堀田 裕一朗, 近藤 真哉, 浅野 涼子, 吉田 浩, 安藤 紀子, 茂田 博行

    神奈川医学会雑誌   48 ( 1 )   36 - 36   2021.1

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  • 子宮平滑筋腫のMED12遺伝子変異と血管新生因子の関連

    浅野涼子, 浅野涼子, 佐藤美紀子, 佐藤美紀子, 水島大一, 永井康一, 宮城悦子

    日本産科婦人科学会雑誌   73   2021

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  • 子宮内膜症手術の技を磨く 子宮内膜症によるダグラス窩閉鎖症例に対する逆行性子宮全摘術の手術成績の検討(後方視的検討)

    山本 恵, 吉田 浩, 浅野 涼子, 近藤 真哉, 堀田 裕一朗, 牛尾 江実子, 石川 玲奈, 村田 知恵, 安藤 紀子, 茂田 博行

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [SY9 - 5]   2020.11

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  • 妊娠中にMassive Ovarian Edemaを発症した一例

    斎藤 尚子, 古郡 恵, 茂田 博行, 吉田 浩, 浅野 涼子, 堀田 裕一朗, 石川 玲奈, 村田 千恵, 谷岡 沙紀, 櫻井 静

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 027]   2020.11

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  • 妊娠中に成熟嚢胞奇形腫に対して腹腔鏡下卵巣嚢腫摘出術を施行し術後化学性腹膜炎を発症した1例

    村田 千恵, 古郡 恵, 浅野 涼子, 堀田 裕一朗, 石川 玲奈, 吉田 浩, 茂田 博行

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 628]   2020.11

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  • 頸部筋腫に対する逆行性子宮全摘術の手術成績の検討(後方視的検討)

    山本 恵, 吉田 浩, 浅野 涼子, 近藤 真哉, 堀田 裕一朗, 安藤 紀子, 茂田 博行

    日本産科婦人科内視鏡学会雑誌   36 ( Suppl.I )   [O - 146]   2020.11

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  • 子宮筋腫によるエリスロポエチン発現とMED12変異の関連

    浅野 涼子, 佐藤 美紀子, 水島 大一, 宮城 悦子

    日本産科婦人科学会雑誌   72 ( 臨増 )   S - 304   2020.3

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  • 妊娠中に急速に増大し,腫瘍破裂を来した卵巣原発絨毛癌の1例

    櫻井 静, 浅野 涼子, 山口 尚子, 谷岡 沙紀, 石川 玲奈, 村田 千恵, 堀田 裕一朗, 近藤 真哉, 古郡 恵, 吉田 浩, 安藤 紀子, 茂田 博行

    日本産科婦人科学会雑誌   72 ( 臨増 )   S - 453   2020.3

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  • 下大静脈まで進展した血管内平滑腫症の1例

    今井 雄一, 飯島 崇善, 岡田 悠暉, 久保倉 優香, 佐野 泰子, 萩原 真由美, 柊 一哉, 紙谷 菜津子, 永井 康一, 浅野 涼子, 松永 竜也, 中村 朋美, 宮城 悦子

    神奈川産科婦人科学会誌   56 ( 2 )   147 - 147   2020.2

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  • 下大静脈まで進展した血管内平滑筋腫症の1例

    今井 雄一, 飯島 崇善, 岡田 悠暉, 久保倉 優香, 佐野 泰子, 萩原 真由美, 柊 一哉, 紙谷 菜津子, 永井 康一, 浅野 涼子, 松永 竜也, 中村 朋美, 宮城 悦子

    神奈川医学会雑誌   47 ( 1 )   24 - 24   2020.1

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  • 子宮体癌III、IV期に対する腹腔鏡下手術の臨床成績

    吉田 浩, 古郡 恵, 浅野 涼子, 近藤 真哉, 堀田 裕一朗, 牛尾 江実子, 村田 千恵, 石川 玲奈, 濱田 春, 谷岡 沙紀, 山口 尚子, 櫻井 静, 安藤 紀子, 茂田 博行

    日本癌治療学会学術集会抄録集   57回   P29 - 1   2019.10

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  • 骨盤内巨大播種病巣を有する卵巣癌IIIC期に対しPDSを行い完全切除をし得た一例

    古郡 恵, 吉田 浩, 浅野 涼子, 近藤 真哉, 堀田 裕一朗, 石川 玲奈, 牛尾 江実子, 村田 千恵, 濱田 春, 谷岡 沙紀, 山口 尚子, 櫻井 静, 安藤 紀子, 茂田 博行

    日本癌治療学会学術集会抄録集   57回   P159 - 4   2019.10

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  • 当院における全腹腔鏡下準広汎子宮全摘術の安全性の評価と標準化に向けた今後の課題

    齊藤 真, 松永 竜也, 紙谷 菜津子, 太田 幸秀, 鈴木 幸雄, 浅野 涼子, 今井 雄一, ルイズ横田 奈朋, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   89 - 89   2019.8

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  • 当院における全腹腔鏡下準広汎子宮全摘術の安全性の評価と標準化に向けた今後の課題

    齊藤 真, 松永 竜也, 紙谷 菜津子, 太田 幸秀, 鈴木 幸雄, 浅野 涼子, 今井 雄一, ルイズ横田 奈朋, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   89 - 89   2019.8

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  • 後腹膜鏡による骨盤-傍大動脈リンパ節郭清術

    古郡 恵, 吉田 浩, 浅野 涼子, 近藤 真哉, 堀田 裕一朗, 牛尾 江実子, 石川 玲奈, 村田 千恵, 濱田 春, 谷岡 沙紀, 山口 尚子, 櫻井 静, 安藤 紀子, 茂田 博行

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   204 - 204   2019.8

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  • 当院における子宮体癌鏡視下根治術症例の再発リスク群別の予後についての検討

    吉田 浩, 古郡 恵, 浅野 涼子, 近藤 真哉, 堀田 裕一朗, 石川 玲奈, 牛尾 江美子, 村田 千恵, 谷岡 沙紀, 濱田 春, 山口 尚子, 櫻井 静, 安藤 紀子, 茂田 博行

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   163 - 163   2019.8

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  • 腹腔鏡手術後に生じたポートサイトヘルニア(Port-site hernia; PSH)の3例

    村田 千恵, 吉田 浩, 櫻井 静, 山口 尚子, 谷岡 沙紀, 濱田 春, 牛尾 江実子, 石川 玲奈, 堀田 裕一朗, 古郡 恵, 近藤 真哉, 浅野 涼子, 安藤 紀子, 茂田 博行

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   144 - 144   2019.8

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  • 当院における腹腔鏡下広汎子宮全摘術(TLRH) 腫瘍細胞の飛散予防と予後の検討

    吉田 浩, 古郡 恵, 浅野 涼子, 近藤 真哉, 堀田 祐一郎, 石川 玲奈, 村田 千恵, 牛尾 江美子, 谷岡 沙紀, 濱田 春, 山口 尚子, 櫻井 静, 安藤 紀子, 茂田 博行

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   100 - 100   2019.8

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  • 子の遺伝性乳がん卵巣がん症候群の診断を契機に77歳でリスク低減卵巣卵管摘出術(RRSO)を行い卵管癌の診断に至った一例 本邦での保険診療の限界

    佐野 泰子, 水島 大一, 永井 康一, 浅野 涼子, 須郷 慶信, ルイズ横田 奈朋, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   288 - 288   2019.8

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  • 腹腔鏡下全腟切除を施行した2例

    古郡 恵, 吉田 浩, 浅野 涼子, 近藤 真哉, 堀田 裕一朗, 村田 千恵, 石川 玲奈, 牛尾 江実子, 谷岡 沙紀, 濱田 春, 山口 尚子, 櫻井 静, 安藤 紀子, 茂田 博行

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   209 - 209   2019.8

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  • 重複下大静脈合併における後腹膜鏡下傍大動脈リンパ節郭清術の2例

    石川 玲奈, 古郡 恵, 櫻井 静, 山口 尚子, 谷岡 沙紀, 濱田 春, 牛尾 江実子, 村田 千恵, 堀田 裕一郎, 近藤 真哉, 浅野 涼子, 安藤 紀子, 茂田 博行, 吉田 浩

    日本産科婦人科内視鏡学会雑誌   35 ( Suppl.I )   208 - 208   2019.8

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  • 子宮筋腫によるエリスロポエチン発現のエストロゲン反応性

    浅野 涼子, 佐藤 美紀子, 水島 大一, 中村 朋美, 宮城 悦子

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 400   2019.2

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  • ほかの診療科と連携して治療した稀少部位子宮内膜症の2例

    岡田 悠暉, 中村 朋美, 柊 一哉, 永井 康一, 浅野 涼子, 今井 雄一, 須郷 慶信, 倉澤 健太郎, 宮城 悦子

    日本産科婦人科学会雑誌   71 ( 臨増 )   S - 491   2019.2

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  • 腹腔鏡下子宮摘出術後の性交渉を契機に腟断端離開し、腹腔鏡下に再縫合術を施行した2例

    今井 雄一, 鈴木 幸雄, 紙谷 菜津子, 太田 幸秀, 祐森 明日菜, 齊藤 真, 永井 康一, 浅野 涼子, 須郷 慶信, ルイズ横田 奈朋, 倉澤 健太郎, 松永 竜也, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   381 - 381   2018.8

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  • 腹腔鏡下子宮体癌根治術後にIB期以上と診断された術前子宮体癌IA期相当症例の解析

    浅野 涼子, 鈴木 幸雄, 中口 芳恵, 太田 幸秀, 齊藤 真, 今井 雄一, ルイズ横田 奈朋, 松永 竜也, 齋藤 圭介, 中村 朋美, 佐藤 美紀子, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   453 - 453   2017.8

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  • 緊急手術を要した早期型ポートサイトヘルニアの3例

    紙谷 菜津子, 鈴木 幸雄, 齊藤 真, 浅野 涼子, 須郷 慶信, 松永 竜也, 齊藤 圭介, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   1495 - 1495   2017.8

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  • 全腹腔鏡下子宮全摘術中に腹部から顔面に及ぶ広範囲な皮下気腫を生じた1例

    浅野 涼子, 鈴木 幸雄, 齊藤 真, 青木 美帆子, 齋藤 圭介, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   1162 - 1162   2017.8

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  • 若手医師執刀を中心とした当院のTLHの現状 TLH普及への考察と問題点

    鈴木 幸雄, 齋藤 圭介, 安井 裕子, 太田 幸秀, 齊藤 真, 浅野 涼子, 今井 雄一, 須郷 慶信, ルイズ横田 奈朋, 倉澤 健太郎, 松永 竜也, 佐藤 美紀子, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   969 - 969   2017.8

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  • Long-term changes in women's quality of life after cervical conization

    M. Furugori, M. Asai-Sato, K. Katayama, R. Asano, E. Miyagi

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   26   342 - 342   2016.10

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  • MW2-1 子宮筋腫によるエリスロポエチン産生とその腫瘍増大因子としての機能解析(ミニワークショップ2 婦人科良性腫瘍全般,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)

    浅野 涼子, 佐藤 美紀子, 水島 大一, 佐藤 麻希子, 宮城 悦子, 平原 史樹

    日本産科婦人科學會雜誌   68 ( 2 )   595 - 595   2016

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    CiNii Books

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=456337

  • 細胞極性制御因子/がん遺伝子atypical protein kinase Cλ/τ(aPKC)の異常発現は子宮頸部上皮内病変の予後予測因子である

    MIZUSHIMA DAIICHI, SATO MIKIKO, TOKINAGA AYA, ASANO RYOKO, MOGAMI TAE, MIYAGI ETSUKO, HIRAHARA FUMIKI

    日本産科婦人科学会雑誌   67 ( 2 )   520   2015.2

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    J-GLOBAL

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  • 当院における遠隔転移を伴う上皮性卵巣がん(FIGO stage IV)の予後因子の検討

    MARUYAMA YASUYO, SATO MIKIKO, ASANO RYOKO, MOTOKI YOKO, KAWANO AIKO, MOGAMI TAE, MATSUNAGA TATSUYA, MIYAGI ETSUKO, HIRAHARA FUMIKI

    日本産科婦人科学会雑誌   67 ( 2 )   854 - 854   2015.2

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  • 当院で過去12年間に診断加療した40歳未満の子宮体がん30症例の臨床病理学的背景

    TERANISHI ERI, MOTOKI YOKO, KAWANO AIKO, ASANO RYOKO, MOGAMI TAE, MARUYAMA YASUYO, MATSUNAGA TATSUYA, SATO MIKIKO, MIYAGI ETSUKO, HIRAHARA FUMIKI

    日本産科婦人科学会雑誌   67 ( 2 )   670 - 670   2015.2

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  • 放射線性腸炎、放射線性膀胱炎に対して、高圧酸素療法を施行した1例

    平田 豪, 石原 瑞葉, 上田 麗子, 佐藤 団, 竹島 和美, 笠井 絢子, 高島 邦僚, 茶木 修, 中山 昌樹, 浅野 涼子, 沼崎 令子, 宮城 悦子, 平原 史樹

    日本産科婦人科学会神奈川地方部会会誌   48 ( 1 )   54 - 54   2011.7

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  • 放射線性腸炎、放射線性膀胱炎に対して、高圧酸素療法を施行した一例

    平田 豪, 石原 瑞葉, 上田 麗子, 佐藤 団, 竹島 和美, 笠井 絢子, 高島 邦僚, 茶木 修, 中山 昌樹, 浅野 涼子, 沼崎 令子, 宮城 悦子, 平原 史樹

    神奈川医学会雑誌   38 ( 2 )   195 - 195   2011.7

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  • P1-8-5 子宮内膜症再発症例における疼痛の寛解・維持療法としてのジェノゲスト投与に関する検討(Group8 女性医学・子宮内膜症・他,一般演題,第63回日本産科婦人科学会学術講演会)

    持丸 綾, 榊原 秀也, 浅野 涼子, 北山 玲子, 須郷 慶信, 尾堀 佐知子, 吉崎 敦雄, 永田 智子, 野村 可之, 中村 朋美, 平原 史樹

    日本産科婦人科學會雜誌   63 ( 2 )   486 - 486   2011

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=445991

  • P1-34-12 神奈川県下における子宮内膜症診療の現状第2報 : ジェノゲスト長期投与における継続例と中止例の検討(Group68 子宮内膜症・治療,一般演題,第63回日本産科婦人科学会学術講演会)

    浅野 涼子, 和泉 俊一郎, 榊原 秀也, 鈴木 隆弘, 川内 博人, 田村 みどり, 吉田 浩, 中野 眞佐男, 井上 裕美, 小田 力, 石川 雅彦

    日本産科婦人科學會雜誌   63 ( 2 )   686 - 686   2011

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    CiNii Books

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=446587

  • Diagnosis and management of women with DSD (disorder of sex development)

    Tomonari Hayama, Aiko Kawano, Reiko Nakamura, Yuko Tagami, Ryoko Asano, Akiko Nara, Yasuko Suzuki, Tomoko Nagata, Yoshiyuki Nomura, Kazuko Sumitomo, Mariko Murase, Maki Takei, Hideya Sakakibara, Fumiki Hirahara

    ENDOCRINE JOURNAL   57   S598 - S598   2010.3

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：JAPAN ENDOCRINE SOC  

    Web of Science

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  • P3-35 新しい骨代謝マーカーucOCの臨床における有用性について(Group102 骨粗鬆症2,一般演題,第62回日本産科婦人科学会学術講演会)

    善方 裕美, 浅野 涼子, 葉山 智工, 野村 可之, 倉澤 健太郎, 小林 有紀, 住友 和子, 菊地 律子, 榊原 秀也, 茶木 修, 平原 史樹

    日本産科婦人科學會雜誌   62 ( 2 )   636 - 636   2010

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  • P3-36 新規骨形成マーカーPINPを用いた骨粗鬆症治療の効果判定(Group102 骨粗鬆症2,一般演題,第62回日本産科婦人科学会学術講演会)

    野村 可之, 善方 裕美, 浅野 涼子, 葉山 智工, 倉澤 健太郎, 小林 有紀, 住友 和子, 菊地 律子, 榊原 秀也, 茶木 修, 平原 史樹

    日本産科婦人科學會雜誌   62 ( 2 )   636 - 636   2010

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  • P2-313 神奈川県下における子宮内膜症診療の現状 : 第一報 ジェノゲストについて(Group82 子宮内膜症2,一般演題,第62回日本産科婦人科学会学術講演会)

    浅野 涼子

    日本産科婦人科學會雜誌   62 ( 2 )   569 - 569   2010

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    Language：Japanese   Publisher：日本産科婦人科学会  

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=444698

  • P3-25 SERM治療の有用性 : 当科における長期治療成績から(Group101 骨粗鬆症1,一般演題,第62回日本産科婦人科学会学術講演会)

    中村 麗子, 善方 裕美, 浅野 涼子, 葉山 智工, 野村 可之, 小林 有紀, 住友 和子, 菊地 律子, 榊原 秀也, 平原 史樹, 倉澤 健太郎, 茶木 修

    日本産科婦人科學會雜誌   62 ( 2 )   632 - 632   2010

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  • P2-338 20歳以下の婦人科手術症例に対する診療のあり方と問題点(Group74 思春期,一般演題,第61回日本産科婦人科学会学術講演会)

    磯村 和美, 榊原 秀也, 浅野 涼子, 古野 敦子, 榎本 紀美子, 永田 智子, 野村 可之, 斉藤 圭介, 佐治 晴哉, 茶木 修, 平原 史樹

    日本産科婦人科學會雜誌   61 ( 2 )   638 - 638   2009

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    Other Link： https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=443005

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Presentations

  • 妊娠産褥期に発症した感染性心内膜炎の1例

    稲垣 萌美, 浅野 涼子, 飯沼 綾子, 加藤 宵子, 永田 亮, 香川 愛子, 長野 研二, 長瀬 寛美, 段 泰行, 飛鳥井 邦雄

    神奈川産科婦人科学会誌(0910-2485)49巻2号 Page137(2013.01) 

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  • 当院における切迫早産管理の現況

    齊藤 真, 病院, 産婦人科, 長瀬 寛美, 栃本 昌孝, 飯沼 綾子, 浅野 涼子, 北山 玲子, 香川 愛子, 段 泰行, 飛鳥井 邦雄

    共済医報(0454-7586)61巻4号 Page393-394(2012.11) 

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  • たこつぼ型心筋症により心不全を発症した卵巣嚢腫茎捻転術後の一例

    伊集院 昌郁, 済病院, 産婦人科, 飯沼 綾子, 齊藤 真, 浅野 涼子, 北山 玲子, 香川 愛子, 長瀬 寛美, 段 泰行, 飛鳥井 邦雄

    関東連合産科婦人科学会誌(2186-0610)49巻3号 Page420(2012.08) 

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  • 当院で過去12年間に診断加療した40歳未満の子宮体がん30症例の臨床病理学的背景

    寺西 絵梨, 元木 葉子, 川野 藍子, 浅野 涼子, 最上 多恵, 丸山 康世, 松永 竜也, 佐藤 美紀子, 宮城 悦子, 平原 史樹

    日本産科婦人科学会雑誌(0300-9165)67巻2号 Page670(2015.02) 

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  • 子宮頸癌 バイオマーカーの探索 細胞極性制御因子/がん遺伝子atypical protein kinase Cλ/ι(aPKC)の異常発現は子宮頸部上皮内病変の予後予測因子である

    水島 大一, 佐藤 美紀子, 時長 亜弥, 浅野 涼子, 最上 多恵, 宮城 悦子, 平原 史樹

    日本産科婦人科学会雑誌(0300-9165)67巻2号 Page520(2015.02) 

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  • Pseudo-Meigs症候群を呈した移転性卵巣癌の1例

    浅野 涼子, 院, 産婦人科, 飯沼 綾子, 齊藤 真, 北山 玲子, 須郷 慶信, 香川 愛子, 長瀬 寛美, 段 泰行, 飛鳥井 邦雄

    共済医報(0454-7586)62巻3号 Page296(2013.08) 

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  • 妊娠産褥期に発症した感染性心内膜炎の一例

    稲垣 萌美, 院, 産婦人科, 浅野 涼子, 飯沼 綾子, 加藤 宵子, 永田 亮, 香川 愛子, 長野 研二, 長瀬 寛美, 段 泰行, 飛鳥井 邦雄

    神奈川医学会雑誌(0285-0680)40巻1号 Page30(2013.03) 

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  • 子宮頸癌からの多量性器出血に対する子宮動脈塞栓術後にヘパリン起因性血小板減少症を来した一例

    大野 菜, 横浜市立大学附属病院, 産婦人科, 浅野 涼子, 太田 幸秀, 今井 雄一, 須郷 慶信, ルイズ横田 奈朋, 松永 竜也, 佐藤 美紀子, 宮城 悦子

    関東連合産科婦人科学会誌(2186-0610)54巻3号 Page308(2017.10) 

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  • 婦人科悪性腫瘍により若年で人工閉経に至った患者へのHRTや骨粗鬆症治療の骨密度に対する長期的な効果について

    立花 貴彦, 附属病院, 産婦人科, 須郷 慶信, 太田 幸秀, 鈴木 幸雄, 斉藤 真, 浅野 涼子, 尾堀 佐知子, 倉澤 健太郎, 中村 朋美, 善方 裕美, 菊地 律子, 宮城 悦子

    日本女性医学学会雑誌(2185-8861)25巻Suppl. Page197(2017.10) 

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  • 婦人科良性腫瘍全般 子宮筋腫によるエリスロポエチン産生とその腫瘍増大因子としての機能解析

    浅野 涼子, 生育生殖病態医学教室, 佐藤 美紀子, 水島 大一, 佐藤 麻希子, 宮城 悦子, 平原 史樹

    日本産科婦人科学会雑誌(0300-9165)68巻2号 Page595(2016.02) 

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  • 当院における遠隔転移を伴う上皮性卵巣がん(FIGO stage IV)の予後因子の検討

    丸山 康世, 佐藤 美紀子, 浅野 涼子, 元木 葉子, 川野 藍子, 最上 多恵, 松永 竜也, 宮城 悦子, 平原 史樹

    日本産科婦人科学会雑誌(0300-9165)67巻2号 Page854(2015.02) 

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  • ベバシズマブ投与中に直腸腟痩を形成した子宮頸癌IIIB期再発の一例

    梶山 涼子, 学附属病院, 産婦人科, 齋藤 真, 松永 竜也, 立花 貴彦, 窪田 葵, 大野 菜, 紙谷 菜津子, 安井 裕子, 中口 芳恵, 太田 幸秀, 鈴木 幸雄, 浅野 涼子, 今井 雄一, 須郷 慶喜, ルイズ横田 奈朋, 齊藤 圭介, 中村 朋美, 佐藤 美紀子, 宮城 悦子

    神奈川医学会雑誌(0285-0680)45巻1号 Page45(2018.01) 

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  • Bevacizumab投与中に直腸腟瘻を形成した子宮頸癌IIIB期再発の1例

    梶山 涼子, 齋藤 真, 松永 竜也, 立花 貴彦, 窪田 葵, 大野 菜, 紙谷 菜津子, 安井 裕子, 中口 芳恵, 太田 幸秀, 鈴木 幸雄, 浅野 涼子, 今井 雄一, 須郷 慶喜, ルイズ横田 奈朋, 齊藤 圭介, 中村 朋美, 佐藤 美紀子, 宮城 悦子

    神奈川産科婦人科学会誌(0910-2485)54巻2号 Page180(2018.02) 

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  • 子宮腺筋症に対するジエノゲストの安全使用 25症例の後方視的検討

    大野 菜, 浅野 涼子, 中村 朋美, 太田 幸秀, 鈴木 幸雄, 齋藤 真, 須郷 慶信, 倉澤 健太郎, 榊原 秀也, 宮城 悦子

    日本産科婦人科学会雑誌(0300-9165)70巻2号 Page1023(2018.02) 

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  • 大学病院における安全なTLHを目指した「福浦メソッド」の成果

    鈴木 幸雄, 産婦人科, 紙谷 菜津子, 太田 幸秀, 祐森 明日菜, 齋藤 真, 永井 康一, 浅野 涼子, 今井 雄一, 須郷 慶信, ルイズ横田 奈朋, 倉澤 健太郎, 松永 竜也, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌(1884-9938)34巻Suppl.I Page187(2018.08) 

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  • 緊急手術を要した早期型ポートサイトヘルニアの3例

    紙谷 菜津子, 学附属病院, 産婦人科, 鈴木 幸雄, 齊藤 真, 浅野 涼子, 須郷 慶信, 松永 竜也, 齊藤 圭介, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌(1884-9938)33巻Suppl.I Page1495(2017.08) 

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  • 全腹腔鏡下子宮全摘術中に腹部から顔面に及ぶ広範囲な皮下気腫を生じた1例

    浅野 涼子, 産婦人科, 鈴木 幸雄, 齊藤 真, 青木 美帆子, 齋藤 圭介, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌(1884-9938)33巻Suppl.I Page1162(2017.08) 

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  • 若手医師執刀を中心とした当院のTLHの現状 TLH普及への考察と問題点

    鈴木 幸雄, 産婦人科, 齋藤 圭介, 安井 裕子, 太田 幸秀, 齊藤 真, 浅野 涼子, 今井 雄一, 須郷 慶信, ルイズ横田 奈朋, 倉澤 健太郎, 松永 竜也, 佐藤 美紀子, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌(1884-9938)33巻Suppl.I Page969(2017.08) 

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  • 腹腔鏡下卵巣腫瘍摘出術後に腹腔内出血を来し重症貧血になったが再手術時に出血点が同定できなかった1例

    窪田 葵, 横浜, 立大学附属病院, 産婦人科, 浅野 涼子, 中口 芳恵, 鈴木 幸雄, 須郷 慶信, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌(1884-9938)34巻Suppl.I Page390(2018.08) 

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  • 当院の全腹腔鏡下子宮全摘術(TLH)の検討から見えた出血リスク因子

    紙谷 菜津子, 附属病院, 産婦人科, 浅野 涼子, 鈴木 幸雄, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌(1884-9938)34巻Suppl.I Page384(2018.08) 

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  • 腹腔鏡下子宮摘出術後の性交渉を契機に腟断端離開し、腹腔鏡下に再縫合術を施行した2例

    今井 雄一, 附属病院, 産婦人科, 鈴木 幸雄, 紙谷 菜津子, 太田 幸秀, 祐森 明日菜, 齊藤 真, 永井 康一, 浅野 涼子, 須郷 慶信, ルイズ横田 奈朋, 倉澤 健太郎, 松永 竜也, 中村 朋美, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌(1884-9938)34巻Suppl.I Page381(2018.08) 

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  • MRI Grading systemを用いて鏡視下手術前に子宮平滑筋腫瘍の悪性度評価を行う 不要な腹腔内散布をさせないために

    鈴木 幸雄, 産婦人科, 和田 真一郎, 今井 一章, 浅野 涼子, 中島 亜矢子, 福士 義将, 中村 朋美, 藤野 敬史, 宮城 悦子

    日本産科婦人科内視鏡学会雑誌(1884-9938)34巻Suppl.I Page320(2018.08) 

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Awards

  • 68th Annual Congress of the Japan Society of Obstetrics and Gynecology, Best Presentation Award

    2016.4   The Japan Society of Obstetrics and Gynecology  

    ASANO Ryoko

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  • Hamada Prize

    2009.7  

    ASANO Ryoko

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Research Projects

  • MED12野生型の子宮筋腫に対する新規治療戦略の確立

    Grant number：22K09599  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    浅野 涼子, 宮城 洋平, 佐藤 美紀子

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Leiomyoma therapy targeting growth effect of erythropoietin

    Grant number：19K09828  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Asano Ryoko

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    Uterine leiomyoma is highly common in women all over the world. However, the methods to predict or prevent leiomyoma growth are not present. We hypothesize that MED12 gene mutation is one of the main reason for the difference in the erythropoietin expression and growth manner of these tumors.
    In this study, we have found that MED12 wild-type leiomyomas have higher CDK8 activation, higher erythropoietin expression, and lower vascular endothelial growth factor expression compared to MED12 mutated leiomyomas. From these findings, we suspect that different cascades work as the main mechanism in the growth of leiomyomas in MED12 wild-type and mutated leiomyomas.

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  • Exploring the novel mechanisms of the massive growth of uterine leiomyoma by Erythropoietin

    Grant number：19K09812  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    SATO Mikiko

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    Previously, we reported that uterine leiomyomas expressing high levels of EPO are greatly enlarged due to enhanced vascular maturation in the tumor. This study showed that EPO expression is caused by different factors than the known myoma driver gene alterations, MED12 mutation, and HMGA1/2 upregulation. Still, we could not elucidate the specific mechanism. In addition, EPHB4 gene expression, an alternative receptor for EPO, is upregulated in EPO-high myomas, suggesting that the EPO-EPHB4 system may be involved in the expansion of uterine leiomyomas. We expect further study to elucidate the molecular mechanisms underlying the development and progression of diverse uterine fibroids and lead to the development of predictive markers for tumor growth and new drug treatment targets.

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Teaching Experience

  • 産婦人科

    Institution：横浜市立大学

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