2025/08/30 更新

所属以外の情報はresearchmapへの登録情報を転載しています。

写真a

ミヤザキ　タクヤ
宮崎 拓也
Takuya Miyazaki
所属
附属市民総合医療センター 血液内科 講師
職名
講師
ホームページ
http://www.ycuhri.com/
プロフィール

2002年高知大学医学部卒業。2010年横浜市立大学大学院博士課程修了。2010-13年米国NIH/NIAID博士研究員。2013-2019年横浜市立大学医学部血液免疫感染症内科学。2020年神奈川県立がんセンター。2021年４月より横浜市立大学附属市民総合医療センター血液内科。資格：日本内科学会認定医、総合内科専門医、指導医。日本血液学会専門医、指導医、評議員。日本造血・免疫細胞療法学会造血細胞移植認定医、評議員。

外部リンク

学位

  • 博士(医学) （ 横浜市立大学 ）

研究キーワード

  • 血液学

研究分野

  • ライフサイエンス / 血液、腫瘍内科学  / 造血器腫瘍、造血幹細胞移植

論文

  • A case of Bloom syndrome manifesting with therapy-related myelodysplastic syndromes harboring a novel BLM gene variant

    Takuma Ohashi, Hiroyoshi Kunimoto, Jun Nukui, Haruka Teshigawara, Satoshi Koyama, Takuya Miyazaki, Maki Hagihara, Kenji Matsumoto, Eriko Koshimizu, Naomi Tsuchida, Haruka Hamanoue, Satoko Miyatake, Akihiro Yachie, Naomichi Matsumoto, Hideaki Nakajima

    International Journal of Hematology   2024年3月

    　詳細を見る

    掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

    DOI： 10.1007/s12185-024-03751-x

    researchmap

    その他リンク： https://link.springer.com/article/10.1007/s12185-024-03751-x/fulltext.html

  • Comparison of standardized prophylactic high-dose and intrathecal methotrexate for DLBCL with a high risk of CNS relapse

    Masahiro Akimoto, Takuya Miyazaki, Hiroyuki Takahashi, Yusuke Saigusa, Takaaki Takeda, Yuto Hibino, Mayumi Tokunaga, Takuma Ohashi, Ayako Matsumura, Haruka Teshigawara, Taisei Suzuki, Hiroshi Teranaka, Yuki Nakajima, Kenji Matsumoto, Chizuko Hashimoto, Katsumichi Fujimaki, Hiroyuki Fujita, Rika Sakai, Shin Fujisawa, Hideaki Nakajima

    International Journal of Hematology   119 ( 2 )   164 - 172   2024年1月

    　詳細を見る

    掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

    DOI： 10.1007/s12185-023-03700-0

    researchmap

    その他リンク： https://link.springer.com/article/10.1007/s12185-023-03700-0/fulltext.html

  • Clinical and genetic features of Japanese cases of MDS associated with VEXAS syndrome.

    Hiroyoshi Kunimoto, Ayaka Miura, Ayaka Maeda, Naomi Tsuchida, Yuri Uchiyama, Yosuke Kunishita, Yuki Nakajima, Kaoru Takase-Minegishi, Ryusuke Yoshimi, Takuya Miyazaki, Maki Hagihara, Etsuko Yamazaki, Yohei Kirino, Naomichi Matsumoto, Hideaki Nakajima

    International journal of hematology   2023年4月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a new disease entity with autoinflammatory disorders (AID) driven by somatic variants in UBA1 that frequently co-exists with myelodysplastic syndromes (MDS). Clinicopathological and molecular features of Japanese cases with VEXAS-associated MDS remain elusive. We previously reported high prevalence of UBA1 variants in Japanese patients with relapsing polychondritis, in which 5 cases co-occurred with MDS. Here, we report clinicopathological and variant profiles of these 5 cases and 2 additional cases of MDS associated with VEXAS syndrome. Clinical characteristics of these cases included high prevalence of macrocytic anemia with marked cytoplasmic vacuoles in myeloid/erythroid precursors and low bone marrow (BM) blast percentages. All cases were classified as low or very low risk by the revised international prognostic scoring system (IPSS-R). Notably, 4 out of 7 cases showed significant improvement of anemia by treatment with prednisolone (PSL) or cyclosporin A (CsA), suggesting that an underlying inflammatory milieu induced by VEXAS syndrome may aggravate macrocytic anemia in VEXAS-associated MDS. Targeted deep sequencing of blood samples suggested that MDS associated with VEXAS syndrome tends to involve a smaller number of genes and lower risk genetic lesions than classical MDS.

    DOI： 10.1007/s12185-023-03598-8

    PubMed

    researchmap

  • Impact of treatment-related weight changes from diagnosis to hematopoietic stem-cell transplantation on clinical outcome of acute myeloid leukemia.

    Taiki Ando, Shin Fujisawa, Haruka Teshigawara, Eriko Ogusa, Yoshimi Ishii, Kazuho Miyashita, Kenji Motohashi, Takuya Miyazaki, Takayoshi Tachibana, Maki Hagihara, Kenji Matsumoto, Masatsugu Tanaka, Chizuko Hashimoto, Hideyuki Koharazawa, Katsumichi Fujimaki, Jun Taguchi, Hiroyuki Fujita, Heiwa Kanamori, Etsuko Yamazaki, Hideaki Nakajima

    International journal of hematology   109 ( 6 )   673 - 683   2019年6月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    We hypothesized that treatment-related weight loss is associated with worse outcomes following HSCT. Overall, 184 patients with AML who underwent induction therapy were classified according to d-BMI (BMI at transplant minus BMI at diagnosis) (kg/m2) as < -2, - 2 to + 2, and > + 2. At 1 year, OS was 67.9% (95% CI, 60.7-74.2), DFS was 64.1% (95% CI, 56.7-70.6), and GRFS was 40.2% (95% CI, 33.1-47.2). For d-BMI groups < - 2, - 2 to + 2, and > + 2, GRFS at 1 year was 16.1% (95% CI, 5.1-31.4), 45.4% (95% CI, 36.4-53.7), and 41.7% (95% CI, 22.2-60.1), respectively (P = 0.0067). Multivariate analysis showed that both worse OS (HR, 1.78; 95% CI, 1.02-3.14; P = 0.007) and GRFS (HR, 2.34; 95% CI, 1.26-4.35; P = 0.007) were associated with reduced BMI (d-BMI < - 2). Treatment-related weight reduction in AML was associated with poor outcome after HSCT.

    DOI： 10.1007/s12185-019-02647-5

    PubMed

    researchmap

  • Primary uterine lymphoma: The Yokohama Cooperative Study Group for Hematology (YACHT) study. 国際誌

    Yoshimi Ishii, Shin Fujisawa, Taiki Ando, Taisei Suzuki, Yasufumi Ishiyama, Kumiko Kishimoto, Yukako Hattori, Yuki Nakajima, Takuya Miyazaki, Hirotaka Takasaki, Kenji Matsumoto, Hideyuki Koharazawa, Jun Taguchi, Katsumichi Fujimaki, Rika Sakai, Hideaki Nakajima

    Asia-Pacific journal of clinical oncology   14 ( 5 )   e455-e459   2018年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    AIM: Primary malignant lymphomas arising from the female genital tract are very rare, with an incidence rate of 0.5%. Because of its rarity, its clinical characteristics, prognosis and optimal treatment are still unclear. Here, we retrospectively evaluated female patients with uterine lymphoma. METHODS: Between January 2000 and October 2016, 4362 patients were newly diagnosed with malignant lymphoma by the participating institutions of YACHT. Among these 4362 patients, we retrospectively evaluated 14 adult patients with primary uterine lymphoma. RESULTS: The median follow up time was 41 months. The median age at diagnosis was 68 years. Of 14 patients, 10 (72%) were diagnosed with diffuse large B-cell lymphoma. Seven patients presented with vaginal bleeding and three with abdominal pain. Eleven patients (79%) had advanced stages at diagnosis. Three patients (21%) had ovarian involvement and 2 (14%) had vaginal involvement. Induction chemotherapy regimens were R-CHOP in seven patients (50%), CHOP in three (21%) and other regimens in four (29%). Among 14 patients, 12 patients (86%) achieved a complete response and 2 (14%) experienced disease progression. Three patients (21%) showed relapse. Five patients (36%) died because of malignant lymphoma. The 3-year overall survival rate was 57.9%. Soluble interleukin-2 receptor levels > 5000 U/mL, anemia, a bulky mass and the presence of > 1 extranodal sites, B symptom at diagnosis were associated with a poor prognosis. CONCLUSION: Female genital lymphoma is very rare, and further study of more cases is warranted.

    DOI： 10.1111/ajco.13049

    PubMed

    researchmap

  • 血液疾患における血清Heme oxygenase-1 血球貪食症候群の鑑別診断への有用性

    宮崎 拓也, 桐野 洋平, 岳野 光洋, 牛濱 歩, 渡辺 玲奈, 高瀬 薫, 立花 崇孝, 松本 憲二, 田中 正嗣, 出口 治子, 富田 直人, 藤田 浩之, 大野 滋, 石ヶ坪 良明

    臨床血液   50 ( 9 )   936 - 936   2009年9月

    　詳細を見る

    記述言語：日本語   出版者・発行元：(一社)日本血液学会-東京事務局  

    researchmap

▼全件表示

MISC

  • Predictive values of early suppression of tumorigenicity 2 for acute GVHD and transplant-related complications after allogeneic stem cell transplantation: prospective observational study

    Ayako Matsumura, Takuya Miyazaki, Takayoshi Tachibana, Taiki Ando, Megumi Koyama, Satoshi Koyama, Yoshimi Ishii, Hiroyuki Takahashi, Yuki Nakajima, Ayumi Numata, Wataru Yamamoto, Kenji Motohashi, Maki Hagihara, Kenji Matsumoto, Shin Fujisawa, Hideaki Nakajima

    Turkish Journal of Hematology   2019年8月

    　詳細を見る

    出版者・発行元：Galenos Yayinevi  

    DOI： 10.4274/tjh.galenos.2019.2019.0139

    researchmap

  • DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice 国際誌

    Tomomi Sakai, Takuya Miyazaki, Dong-Mi Shin, Yong-Soo Kim, Chen-Feng Qi, Robert Fariss, Jeeva Munasinghe, Hongsheng Wang, Alexander L. Kovalchuk, Parul H. Kothari, Charles S. Fermaintt, John P. Atkinson, Fred W. Perrino, Nan Yan, Herbert C. Morse

    Journal of Autoimmunity   81   13 - 23   2017年7月

    　詳細を見る

    記述言語：英語   出版者・発行元：Elsevier BV  

    TREX1/DNASE III, the most abundant 3'-5' DNA exonuclease in mammalian cells, is tail-anchored on the endoplasmic reticulum (ER). Mutations at the N-terminus affecting TREX1 DNase activity are associated with autoimmune and inflammatory conditions such as Aicardi-Goutières syndrome (AGS). Mutations in the C-terminus of TREX1 cause loss of localization to the ER and dysregulation of oligosaccharyltransferase (OST) activity, and are associated with retinal vasculopathy with cerebral leukodystrophy (RVCL) and in some cases with systemic lupus erythematosus (SLE). Here we investigate mice with conditional expression of the most common RVCL mutation, V235fs, and another mouse expressing a conditional C-terminal mutation, D272fs, associated with a case of human SLE. Mice homozygous for either mutant allele express the encoded human TREX1 truncations without endogenous mouse TREX1, and both remain DNase active in tissues. The two mouse strains are similar phenotypically without major signs of retinal, cerebral or renal disease but exhibit striking elevations of autoantibodies in the serum. The broad range of autoantibodies is primarily against non-nuclear antigens, in sharp contrast to the predominantly DNA-related autoantibodies produced by a TREX1-D18N mouse that specifically lacks DNase activity. We also found that treatment with an OST inhibitor, aclacinomycin, rapidly suppressed autoantibody production in the TREX1 frame-shift mutant mice. Together, our study presents two new mouse models based on TREX1 frame-shift mutations with a unique set of serologic autoimmune-like phenotypes.

    DOI： 10.1016/j.jaut.2017.03.001

    PubMed

    researchmap

  • 天疱瘡を契機に診断された硝子血管型Castleman病のstroma rich variant

    高橋 寛行, 武山 紘子, 金岡 美和, 江中 牧子, 宮崎 拓也, 桐野 洋平, 萩原 真紀, 松本 憲二, 山中 正二, 中島 秀明

    日本リンパ網内系学会会誌   57   110 - 110   2017年5月

    　詳細を見る

    記述言語：日本語   出版者・発行元：(一社)日本リンパ網内系学会  

    researchmap

  • Impact of the Difference in Body Mass Index at Transplantation from That at Diagnosis for Graft-Versus-Host Disease-Free, Relapse-Free Survival in Acute Myeloid Leukemia

    Taiki Ando, Etsuko Yamazaki, Haruka Teshigawara, Eriko Ogusa, Yoshimi Ishii, Kazuho Miyashita, Kenji Motohashi, Takuya Miyazaki, Takayoshi Tachibana, Maki Hagihara, Kenji Matsumoto, Masatsugu Tanaka, Chizuko Hashimoto, Hideyuki Koharazawa, Katsumichi Fujimaki, Jun Taguchi, Hiroyuki Fujita, Heiwa Kanamori, Shin Fujisawa, Hideaki Nakajima

    BLOOD   128 ( 22 )   2016年12月

    　詳細を見る

    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

    researchmap

  • Identification of Bone Marrow Involvement of FL: Comparison of PET-CT and Bone Marrow Biopsy.

    Yuki Nakajima, Shin Fujisawa, Chika Nigauri, Teshigawara Haruka, Ayako Matsumura, Taiki Ando, Taisei Suzuki, Eri Yamamoto, Eriko Ogusa, Yoshimi Ishii, Hiroyuki Takahashi, Kazuho Miyashita, Reina Watanabe, Takuya Miyazaki, Kenji Motohashi, Atsuko Fujita, Maki Hagihara, Kenji Matsumoto, Hideaki Nakajima

    BLOOD   128 ( 22 )   2016年12月

    　詳細を見る

    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

    researchmap

  • Successful induction therapy for acute myeloid leukemia complicated with brain hemorrhage and hyperleukocytosis

    Takuya Miyazaki, Nana Abe, Etsuko Yamazaki, Satoshi Koyama, Kazuho Miyashita, Hiroyuki Takahashi, Yuki Nakajima, Takayoshi Tachibana, Aki Kamijo, Naoto Tomita, Yoshiaki Ishigastubo

    2016年2月

    　詳細を見る

  • Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation 査読

    Maroof Hasan, Charles S. Fermaintt, Ningguo Gao, Tomomi Sakai, Takuya Miyazaki, Sixin Jiang, Quan-Zhen Li, John P. Atkinson, Herbert C. Morse, Mark A. Lehman, Nan Yan

    IMMUNITY   43 ( 3 )   463 - 474   2015年9月

    　詳細を見る

  • Beta-2 Microglobulin As a Strong Prognostic Factor in Patients with Diffuse Large B-Cell Lymphoma Treated with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone

    Kazuho Miyashita, Naoto Tomita, Masataka Taguri, Taisei Suzuki, Yasufumi Ishiyama, Yoshimi Ishii, Ayumi Numata, Yukako Hattori, Wataru Yamamoto, Takuya Miyazaki, Takayoshi Tachibana, Hirotaka Takasaki, Kenji Matsumoto, Chizuko Hashimoto, Sachiya Takemura, Etsuko Yamazaki, Katsumichi Fujimaki, Rika Sakai, Shigeki Motomura, Yoshiaki Ishigatsubo

    BLOOD   124 ( 21 )   2014年12月

    　詳細を見る

    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

    researchmap

  • No Outcome Differences Were Observed Between Supra-Diaphragmatic and Infra-Diaphragmatic Lesions in Limited-Stage Diffuse Large B Cell Lymphoma Treated with R-CHOP Therapy, Whereas the Presence of Gastro-Intestinal Lesions Was Associated with a Favorable Prognosis

    Yuki Nakajima, Naoto Tomita, Megumi Itabashi, Kazuho Miyashita, Reina Watanabe, Takuya Miyazaki, Takayoshi Tachibana, Hirotaka Takasaki, Rika Kawasaki, Masatsugu Tanaka, Chizuko Hashimoto, Etsuko Yamazaki, Jun Taguchi, Katsumichi Fujimaki, Rika Sakai, Hiroyuki Fujita, Shin Fujisawa, Hiroshi Harano, Shigeki Motomura, Yoshiaki Ishigatsubo

    BLOOD   124 ( 21 )   2014年12月

    　詳細を見る

    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

    researchmap

  • The 3 '-5 ' DNA Exonuclease TREX1 Directly Interacts with Poly(ADP-ribose) Polymerase-1 (PARP1) during the DNA Damage Response 査読

    Takuya Miyazaki, Yong-Soo Kim, Jeongheon Yoon, Hongsheng Wang, Teruhiko Suzuki, Herbert C. Morse

    JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 47 )   32548 - 32558   2014年11月

    　詳細を見る

  • [T315I positive promyelocytic crisis of chronic myeloid leukemia].

    Eri Yamamoto, Etsuko Yamazaki, Yasufumi Ishiyama, Satoshi Koyama, Yoshimi Ishii, Yukako Hattori, Yuki Nakajima, Takayoshi Tachibana, Takuya Miyazaki, Maki Hagihara, Naoto Tomita, Yoshiaki Ishigatsubo

    [Rinshō ketsueki] The Japanese journal of clinical hematology   55 ( 6 )   692 - 696   2014年

    　詳細を見る

    記述言語：日本語   掲載種別：書評論文，書評，文献紹介等  

    Scopus

    PubMed

    researchmap

  • Minimal residual disease-based risk stratification in acute myeloid leukemia 査読

    Takuya Miyazaki

    LEUKEMIA RESEARCH   37 ( 12 )   1603 - 1604   2013年12月

    　詳細を見る

  • Clinical significance of minimal residual disease detected by multidimensional flow cytometry: Serial monitoring after allogeneic stem cell transplantation for acute leukemia 査読

    Takuya Miyazaki, Hiroyuki Fujita, Katsumichi Fujimaki, Takeshi Hosoyama, Reina Watanabe, Takayoshi Tachibana, Atsuko Fujita, Kenji Matsumoto, Masatsugu Tanaka, Hideyuki Koharazawa, Jun Taguchi, Naoto Tomita, Rika Sakai, Shin Fujisawa, Heiwa Kanamori, Yoshiaki Ishigatsubo

    LEUKEMIA RESEARCH   36 ( 8 )   998 - 1003   2012年8月

    　詳細を見る

  • Bach1 regulates osteoclastogenesis in a mouse model via both heme oxygenase 1-dependent and heme oxygenase 1-independent pathways 査読

    Maasa Hama, Yohei Kirino, Mitsuhiro Takeno, Kaoru Takase, Takuya Miyazaki, Ryusuke Yoshimi, Atsuhisa Ueda, Ari Itoh-Nakadai, Akihiko Muto, Kazuhiko Igarashi, Yoshiaki Ishigatsubo

    ARTHRITIS AND RHEUMATISM   64 ( 5 )   1518 - 1528   2012年5月

    　詳細を見る

  • Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1 査読

    Takuya Miyazaki, Yohei Kirino, Mitsuhiro Takeno, Sei Samukawa, Maasa Hama, Masatsugu Tanaka, Satoshi Yamaji, Atsuhisa Ueda, Naoto Tomita, Hiroyuki Fujita, Yoshiaki Ishigatsubo

    CANCER SCIENCE   101 ( 6 )   1409 - 1416   2010年6月

    　詳細を見る

  • Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions 査読

    Takuya Miyazaki, Yohei Kirino, Mitsuhiro Takeno, Maasa Hama, Ayumi Ushihama, Reina Watanabe, Kaoru Takase, Takayoshi Tachibana, Kenji Matsumoto, Masatsugu Tanaka, Satoshi Yamaji, Haruko Ideguchi, Naoto Tomita, Hiroyuki Fujita, Shigeru Ohno, Atsuhisa Ueda, Yoshiaki Ishigatsubo

    INTERNATIONAL JOURNAL OF HEMATOLOGY   91 ( 2 )   229 - 237   2010年3月

    　詳細を見る

  • 【関節リウマチ合併症の診断と対処法】リンパ増殖性疾患

    岳野 光洋, 宮崎 拓也

    リウマチ科   41 ( 4 )   395 - 400   2009年4月

    　詳細を見る

    記述言語：日本語   出版者・発行元：(有)科学評論社  

    researchmap

  • Remission of lymphoma after withdrawal of methotrexate in rheumatoid arthritis: Relationship with type of latent Epstein-Barr virus infection 査読

    Takuya Miyazaki, Katsumichi Fujimaki, Yukari Shirasugi, Fumiaki Yoshiba, Manabu Ohsaka, Koji Miyazaki, Etsuko Yamazaki, Rika Sakai, Jun-Ichi Tamaru, Kenji Kishi, Heiwa Kanamori, Masaaki Higashihara, Tomomitsu Hotta, Yoshiaki Ishigatsubo

    AMERICAN JOURNAL OF HEMATOLOGY   82 ( 12 )   1106 - 1109   2007年12月

    　詳細を見る

  • [Pure red cell aplasia in patients treated with recombinant erythropoietin for anemia due to chronic renal disease]. 査読

    Miyazaki T, Obana T, Takasaki H, Tanaka M, Yamaji S, Fujimaki K, Fujita H, Kanamori H, Ishigatsubo Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   48 ( 5 )   391 - 396   2007年5月

    　詳細を見る

  • [Multiple myeloma presenting as cavernous sinus syndrome]. 査読

    Miyazaki T, Taguchi J, Obana T, Yamaji S, Koharazawa H, Fujimaki K, Kanamori H, Ishigatsubo Y

    [Rinsho ketsueki] The Japanese journal of clinical hematology   47 ( 10 )   1393 - 1395   2006年10月

    　詳細を見る

    記述言語：日本語   出版者・発行元：一般社団法人 日本血液学会  

    We report on a 70-year-old male who developed cavernous sinus syndrome as the initial symptom of multiple myeloma. He was admitted with diplopia and ptosis in October 2004. The diagnosis of multiple myeloma and cavernous sinus syndrome due to a gross mass at the sinus base were made. Cerebral computed tomography revealed that the lesion occupied the sphenoid sinus and involved the oculomoter nerve. He underwent local irradiation of the mass followed by systemic chemotherapy. The symptoms caused by the mass disappeared after the treatment. Clinicians need to be aware of the rare manifestation of multiple myeloma.

    DOI： 10.11406/rinketsu.47.1393

    PubMed

    CiNii Books

    researchmap

    その他リンク： http://search.jamas.or.jp/link/ui/2007077405

▼全件表示