Updated on 2025/06/23

All information, except for affiliations, is reprinted from the information registered on researchmap.

写真a

 
Wataru Ota
 
Organization
Graduate School of Medicine Department of Medicine Physiology Assistant Professor
School of Medicine Medical Course
Title
Assistant Professor
Homepage
https://www.researchgate.net/profile/Wataru-Ota
Profile

Wataru OTA (Ph.D.)

Assistant Professor

Medical Education Center / Department of Physiology
Yokohama City University School of Medicine

3-9 Fuku-ura, Kanazawa-ku,
Yokohama 236-0004, Japan

Lab Website
http://neurosci.med.yokohama-cu.ac.jp/

External link

Degree

  • Ph.D. (Doctor of Agricultural Science) ( Nagoya University )

Research Interests

  • AMPA receptor

  • Animal Behavioral Physiology

  • Chronobiology

  • Thermal Biology

  • Synaptic Plasticity

  • Neuropsychiatric Disorder

Research Areas

  • Life Science / Psychiatry

  • Life Science / Animal life science

  • Life Science / Animal physiological chemistry, physiology and behavioral biology

  • Life Science / Neuroscience-general

Education

  • Nagoya University   Graduate School of Bioagricultural Sciences (Doctoral Course)   Laboratory of Animal Physiology (Prof. Takashi Yoshimura), Division of Applied Genetics and Physiology, Department of Applied Molecular Biosciences

    2013.4 - 2016.3

    　 More details

    Country： Japan

    researchmap

  • Nagoya University   Graduate School of Bioagricultural Sciences (Master's Course)   Laboratory of Animal Physiology (Prof. Takashi Yoshimura), Division of Applied Genetics and Physiology, Department of Applied Molecular Biosciences

    2011.4 - 2013.3

    　 More details

    Country： Japan

    researchmap

  • Nagoya University   School of Agricultural Sciences   Department of Bioresource Sciences

    2007.4 - 2011.3

    　 More details

    Country： Japan

    researchmap

  • Mie Prefecture Yokkaichi Senior High School   General Courses   Super Science High School (SSH) Course

    2004.4 - 2007.3

    　 More details

Research History

  • Yokohama City University School of Medicine,   Medical Education Center / Department of Physiology,   Assistant Professor

    2021.2

    　 More details

    Country：Japan

    researchmap

  • Yokohama City University School of Medicine,   Department of Physiology,   Project Assistant Professor

    2019.6 - 2021.1

    　 More details

  • Nagoya University   Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences (Institute of Transformative Bio-Molecules [WPI-ITbM]),   Technical Assistant

    2018.4 - 2019.4

    　 More details

  • Nagoya University   Laboratory of Animal Physiology, Graduate School of Bioagricultural Sciences (Institute of Transformative Bio-Molecules [WPI-ITbM]),   Technical Assistant

    2016.4 - 2018.3

    　 More details

  • JSPS Research Fellow (DC2)

    2014.4 - 2016.3

    　 More details

Professional Memberships

  • The Physiological Society of Japan

    2022

    　 More details

  • Japanese Association for the Advancement of Science

    2022

    　 More details

  • Preparatory committee for the establishment of the Japanese Association for the Advancement of Science

    2021 - 2022

    　 More details

  • The Japan Neuroscience Society

    2020

    　 More details

  • Society for Research on Biological Rhythms

    2015

    　 More details

  • European Biological Rhythms Society

    2015 - 2016

    　 More details

  • The Molecular Biology Society of Japan

    2013 - 2014

    　 More details

  • Japanese Society of Animal Science

    2012 - 2015

    　 More details

  • Japanese Society for Science Visualization

    2011

    　 More details

  • Japanese Society for Chronobiology

    2010

    　 More details

▼display all

Committee Memberships

  • IYNA Japan   IYNA Japan アドバイザー  

    2025.3   

    　 More details

  • 横浜市立大学（福浦キャンパス）   「化学物質管理者」及び「保護具着用責任者」  

    2024.4   

    　 More details

  • 学術変革領域研究 (A)「臨界期生物学 (iPlasticity)」   若手支援運営メンバー  

    2024.4 - 2025.3   

    　 More details

  • Students' Idea Factory   Co-Chair  

    2024.1   

    　 More details

    Committee type：Academic society

    Official Web site（https://si-fa.net/）

    researchmap

  • 横浜市立大学 環境管理委員会   委員  

    2023.4   

    　 More details

  • 日本科学振興協会   年次大会 2023 実行委員（運営委員長）  

    2022.12 - 2024.3   

    　 More details

    Committee type：Academic society

    researchmap

  • Japanese Society for Chronobiology   Council Member  

    2022.9   

    　 More details

    Committee type：Academic society

    researchmap

  • 学術変革領域研究 (A)「臨界期生物学 (iPlasticity)」   夏の領域班会議 2022 事務局 兼 ポスター発表会 実行委員会  

    2022.6 - 2022.8   

    　 More details

  • Japanese Association for the Advancement of Science (JAAS, Non-Profit Organization)   Director  

    2022.2 - 2024.6   

    　 More details

    Committee type：Academic society

    researchmap

  • 日本科学振興協会   第 1 回 総会・キックオフミーティング 実行委員  

    2022.1 - 2022.6   

    　 More details

    Committee type：Academic society

    researchmap

  • Japanese Association for the Advancement of Science (JAAS, private organization)   Director  

    2021.8 - 2022.2   

    　 More details

    Committee type：Academic society

    researchmap

  • Preparatory committee for the establishment of the Japanese Association for the Advancement of Science (JAAS)   Member  

    2021.3 - 2022.6   

    　 More details

    Committee type：Academic society

    researchmap

  • Medical Education Center, Yokohama City University School of Medicine   Full-time faculty member of the Medical Education center  

    2021.2   

    　 More details

▼display all

Papers

  • Edonerpic maleate enhances functional recovery from spinal cord injury with cortical reorganization in non-human primates Reviewed

    Koichi Uramaru, Hiroki Abe, Waki Nakajima, Wataru Ota, Michiaki Suzuki, Osamu Yokoyama, Tetsuya Yamamoto, Yukio Nishimura, Takuya Takahashi

    Brain Communications   7 ( 2 )   fcaf036   2025.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/braincomms/fcaf036

    researchmap

  • Edonerpic maleate prevents epileptic seizure during recovery from brain damage by balancing excitatory and inhibitory inputs Reviewed

    Yuki Katsuno, Susumu Jitsuki, Wataru Ota, Tomomi Yamanoue, Hiroki Abe, Takuya Takahashi

    Frontiers in Neural Circuits   18   2024.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media SA  

    Functional recovery from brain damage, such as stroke, is a plastic process in the brain. The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) plays a crucial role in neuronal functions, and the synaptic trafficking of AMPAR is a fundamental mechanism underlying synaptic plasticity. We recently identified a collapsin response mediator protein 2 (CRMP2)-binding compound, edonerpic maleate, which augments rehabilitative training-dependent functional recovery from brain damage by facilitating experience-driven synaptic delivery of AMPARs. In animals recovering from cryogenic brain injury, a potential compensatory area adjacent to the injured region was observed, where the injection of CNQX, an AMPAR antagonist, significantly attenuated functional recovery. In the compensatory brain area of animals recovering from cryogenic injury, the administration of edonerpic maleate enhanced both excitatory and inhibitory synaptic inputs at pyramidal neurons. In contrast, recovered animals that did not receive the drug exhibited augmentation of only excitatory synaptic input. The threshold of picrotoxin-induced epileptic seizure in recovered animals without edonerpic maleate treatment was lower than in intact animals and recovered animals with edonerpic maleate. Thus, edonerpic maleate enhances motor function recovery from brain damage by balancing excitatory and inhibitory synaptic inputs, which helps prevent epileptic seizures during recovery.

    DOI： 10.3389/fncir.2024.1492043

    researchmap

  • Synthesis and preclinical testing of a selective beta-subtype agonist of thyroid hormone receptor ZTA-261 Reviewed

    Masakazu Nambo, Taeko Nishiwaki-Ohkawa, Akihiro Ito, Zachary T. Ariki, Yuka Ito, Yuuki Kato, Muhammad Yar, Jacky C. -H. Yim, Emily Kim, Elizabeth Sharkey, Keiko Kano, Emi Mishiro-Sato, Kosuke Okimura, Michiyo Maruyama, Wataru Ota, Yuko Furukawa, Tomoya Nakayama, Misato Kobayashi, Fumihiko Horio, Ayato Sato, Cathleen M. Crudden, Takashi Yoshimura

    Communications Medicine   4 ( 152 )   2024.8

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Background

    Thyroid hormones (TH) regulate the basal metabolic rate through their receptors THRα and THRβ. TH activates lipid metabolism via THRβ, however, an excess amount of TH can lead to tachycardia, bone loss, and muscle wasting through THRα. In recent years, TH analogs that selectively bind to THRβ have gained attention as new agents for treating dyslipidemia and obesity, which continue to pose major challenges to public health worldwide.

    Methods

    We developed a TH analog, ZTA-261, by modifying the existing THRβ-selective agonists GC-1 and GC-24. To determine the THRβ-selectivity of ZTA-261, an in vitro radiolabeled TH displacement assay was conducted. ZTA-261 was intraperitoneally injected into a mouse model of high-fat diet-induced obesity, and its effectiveness in reducing body weight and visceral fat, and improving lipid metabolism was assessed. In addition, its toxicity in the liver, heart, and bone was evaluated.

    Results

    ZTA-261 is more selective towards THRβ than GC-1. Although ZTA-261 is less effective in reducing body weight and visceral fat than GC-1, it is as effective as GC-1 in reducing the levels of serum and liver lipids. These effects are mediated by the same pathway as that of T<sub>3</sub>, a natural TH, as evidenced by similar changes in the expression of TH-induced and lipid metabolism-related genes. The bone, cardiac, and hepatotoxicity of ZTA-261 are significantly lower than those of GC-1.

    Conclusions

    ZTA-261, a highly selective and less toxic THRβ agonist, has the potential to be used as a drug for treating diseases related to lipid metabolism.

    DOI： 10.1038/s43856-024-00574-z

    researchmap

    Other Link： https://www.nature.com/articles/s43856-024-00574-z

  • Synthesis of [18F] fluorine-labeled K-2 derivatives as radiotracers for AMPA receptors Reviewed

    Tetsu Arisawa, Kimito Kimura, Tomoyuki Miyazaki, Yuuki Takada, Waki Nakajima, Wataru Ota, Sadamitsu Ichijo, Akane Sano, Yuuka Hirao, Kurita Jun-ichi, Yoshifumi Nishimura, Takuya Takahashi

    Nuclear Medicine and Biology   110   47 - 58   2022.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE INC  

    Introduction: AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor) receptors play a central role in neurotransmission and neuronal function. A positron emission tomography (PET) tracer for AMPA re-ceptors, [C-11]K-2, was recently developed by us to visualize AMPA receptors in the living human brain. [C-11]K-2 is a derivative of 4-[2-(phenylsulphonylamino)ethylthio]-2,6-difuluoro-phenoxyacetamide (PEPA), and is labeled with the radioactive isotope C-11, which has a short half-life. PET drugs are usually labeled with F-18 because of its long half-life. Therefore, we screened and identified potential F-18-labeled PET drugs for AMPA receptors (AMPA-PET drugs), which could provide an image equivalent to that of [C-11]K-2. Methods: Derivatives of K-2 labeled with F-18 were synthesized and administered to rats and PET imaging was performed. The transferability of each compound to the brain and its correlation with the PET image of [C-11]K-2 were evaluated from the obtained PET images. Furthermore, the specific binding ability of promising compounds to the AMPA receptor was evaluated by the PET imaging of rats, which we specifically knocked down the expression of AMPA by the lentivirus-mediated introduction of short hairpin RNA (shRNA) targeted to subunits of the AMPA receptor (GluA1-A3). The specific binding ability was also evaluated through electrophysiological experiments with acute brain slices. Results: Some of the synthesized F-18-labeled candidate compounds showed a distribution similar to that of K-2, with reasonable transferability to the brain. In addition, from the evaluation of the specific binding ability to the AMPA receptor, a promising structure of an 18F-labeled AMPA PET drug was identified. This study also revealed that the alkylation of the sulfonamide group of PEPA enhances brain transferability.

    DOI： 10.1016/j.nucmedbio.2022.04.009

    Web of Science

    researchmap

  • [11C]K-2 image with positron emission tomography represents cell surface AMPA receptors Reviewed International journal

    Tetsu Arisawa, Tomoyuki Miyazaki, Wataru Ota, Akane Sano, Kumiko Suyama, Yuuki Takada, Takuya Takahashi

    Neuroscience Research   173   106 - 113   2021.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    The glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) is an important molecule in neurotransmission. We have recently developed the first positron emission tomography (PET) tracer [11C]K-2 to visualize and quantify AMPARs in the living human brain. After injection, [11C]K-2 is hydrolyzed at the terminal amide (and is thus metabolized to a major metabolite, [11C]K-2OH) within 10 min, representing the PET image in rodents and humans. Here, we found that K-2OH did not penetrate the cell membrane but slowly passed through the blood brain barrier (BBB) with paracellular transport. Furthermore, major efflux transporters in the BBB did not carry K-2OH. Logan graphical analysis exhibited reversible binding kinetics of this radiotracer in healthy individuals; these results demonstrated that the PET image of this tracer represents cell surface AMPARs with passive penetration of [11C]K-2OH through the BBB, resulting in reversible binding kinetics. Thus, PET images with this tracer depict the physiologically crucial fraction of AMPARs.

    DOI： 10.1016/j.neures.2021.05.009

    PubMed

    researchmap

  • Action spectrum for photoperiodic control of thyroid-stimulating hormone in Japanese quail (Coturnix japonica) Reviewed International journal

    Yusuke Nakane, Ai Shinomiya, Wataru Ota, Keisuke Ikegami, Tsuyoshi Shimmura, Sho-Ichi Higashi, Yasuhiro Kamei, Takashi Yoshimura

    PLoS ONE   14 ( 9 )   e0222106   2019.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    At higher latitudes, vertebrates exhibit a seasonal cycle of reproduction in response to changes in day-length, referred to as photoperiodism. Extended day-length induces thyroid-stimulating hormone in the pars tuberalis of the pituitary gland. This hormone triggers the local activation of thyroid hormone in the mediobasal hypothalamus and eventually induces gonadal development. In avian species, light information associated with day-length is detected through photoreceptors located in deep-brain regions. Within these regions, the expressions of multiple photoreceptive molecules, opsins, have been observed. However, even though the Japanese quail is an excellent model for photoperiodism because of its robust and significant seasonal responses in reproduction, a comprehensive understanding of photoreceptors in the quail brain remains undeveloped. In this study, we initially analyzed an action spectrum using photoperiodically induced expression of the beta subunit genes of thyroid-stimulating hormone in quail. Among seven wavelengths examined, we detected maximum sensitivity of the action spectrum at 500 nm. The low value for goodness of fit in the alignment with a template of retinal1-based photopigment, assuming a spectrum associated with a single opsin, proposed the possible involvement of multiple opsins rather than a single opsin. Analysis of gene expression in the septal region and hypothalamus, regions hypothesized to be photosensitive in quail, revealed mRNA expression of a mammal-like melanopsin in the infundibular nucleus within the mediobasal hypothalamus. However, no significant diurnal changes were observed for genes in the infundibular nucleus. Xenopus-like melanopsin, a further isoform of melanopsin in birds, was detected in neither the septal region nor the infundibular nucleus. These results suggest that the mammal-like melanopsin expressed in the infundibular nucleus within the mediobasal hypothalamus could be candidate deep-brain photoreceptive molecule in Japanese quail. Investigation of the functional involvement of mammal-like melanopsin-expressing cells in photoperiodism will be required for further conclusions.

    DOI： 10.1371/journal.pone.0222106

    PubMed

    researchmap

  • Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior Reviewed

    Wataru Ota, Yusuke Nakane, Makiko Kashio, Yoshiro Suzuki, Kazuhiro Nakamura, Yasuo Mori, Makoto Tominaga, Takashi Yoshimura

    Scientific Reports   9 ( 1 )   3706   2019.3

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Nature  

    DOI： 10.1038/s41598-019-40067-x

    researchmap

  • Impaired Circadian Photoentrainment in Opn5-Null Mice. Reviewed

    Ota W, Nakane Y, Hattar S, Yoshimura T

    iScience   6   299 - 305   2018.8

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.isci.2018.08.010

    PubMed

    researchmap

  • Identification of circadian clock modulators from existing drugs. Reviewed International journal

    T Katherine Tamai, Yusuke Nakane, Wataru Ota, Akane Kobayashi, Masateru Ishiguro, Naoya Kadofusa, Keisuke Ikegami, Kazuhiro Yagita, Yasufumi Shigeyoshi, Masaki Sudo, Taeko Nishiwaki-Ohkawa, Ayato Sato, Takashi Yoshimura

    EMBO Molecular Medicine   10 ( 5 )   e8724   2018.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Chronic circadian disruption due to shift work or frequent travel across time zones leads to jet-lag and an increased risk of diabetes, cardiovascular disease, and cancer. The development of new pharmaceuticals to treat circadian disorders, however, is costly and hugely time-consuming. We therefore performed a high-throughput chemical screen of existing drugs for circadian clock modulators in human U2OS cells, with the aim of repurposing known bioactive compounds. Approximately 5% of the drugs screened altered circadian period, including the period-shortening compound dehydroepiandrosterone (DHEA; also known as prasterone). DHEA is one of the most abundant circulating steroid hormones in humans and is available as a dietary supplement in the USA Dietary administration of DHEA to mice shortened free-running circadian period and accelerated re-entrainment to advanced light-dark (LD) cycles, thereby reducing jet-lag. Our drug screen also revealed the involvement of tyrosine kinases, ABL1 and ABL2, and the BCR serine/threonine kinase in regulating circadian period. Thus, drug repurposing is a useful approach to identify new circadian clock modulators and potential therapies for circadian disorders.

    DOI： 10.15252/emmm.201708724

    PubMed

    researchmap

  • Different photoperiodic responses in four lines of Japanese quail. Reviewed

    Yusuke Atsumi, Eriko Yorinaga, Wataru Ota, Takashi Yoshimura

    The Journal of Poultry Science   53 ( 1 )   63 - 66   2016.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：JAPAN POULTRY SCIENCE ASSOC  

    Organisms measure day length to better adapt to seasonal changes in the environment; this phenomenon is called photoperiodism. The Japanese quail has a highly sophisticated photoperiodic mechanism and is an excellent model for the study of photoperiodism. Various lines of quail have been established during the domestication process. In the present study, we examined the effect of long day (LD) followed by short day (SD) on testicular weight in four lines of quail (L, AMRP, NIES-Br, and WE). When the quail were raised under SD conditions, testicular development was suppressed in all examined lines. The speed of the LD-induced testicular development of NIES-Br line was faster than that of AMRP line, while the speed of the SD-induced testicular regression of L line was significantly faster than that of WE line. These quail lines provide excellent model to uncover the underlying mechanism of seasonal testicular regression.

    DOI： 10.2141/jpsa.0150097

    Web of Science

    researchmap

  • Low temperature-induced circulating triiodothyronine accelerates seasonal testicular regression. Reviewed

    Ikegami K, Atsumi Y, Yorinaga E, Ono H, Murayama I, Nakane Y, Ota W, Arai N, Tega A, Iigo M, Darras VM, Tsutsui K, Hayashi Y, Yoshida S, Yoshimura T

    Endocrinology   156 ( 2 )   647 - 659   2015.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ENDOCRINE SOC  

    In temperate zones, animals restrict breeding to specific seasons to maximize the survival of their offspring. Birds have evolved highly sophisticated mechanisms of seasonal regulation, and their testicular mass can change 100-fold within a few weeks. Recent studies on Japanese quail revealed that seasonal gonadal development is regulated by central thyroid hormone activation within the hypothalamus, depending on the photoperiodic changes. By contrast, the mechanisms underlying seasonal testicular regression remain unclear. Here we show the effects of short day and low temperature on testicular regression in quail. Low temperature stimulus accelerated short day-induced testicular regression by shutting down the hypothalamus-pituitary-gonadal axis and inducing meiotic arrest and germ cell apoptosis. Induction of T-3 coincided with the climax of testicular regression. Temporal gene expression analysis over the course of apoptosis revealed the suppression of LH response genes and activation of T-3 response genes involved in amphibian metamorphosis within the testis. Daily ip administration of T-3 mimicked the effects of low temperature stimulus on germ cell apoptosis and testicular mass. Although type 2 deiodinase, a thyroid hormone-activating enzyme, in the brown adipose tissue generates circulating T-3 under low-temperature conditions in mammals, there is no distinct brown adipose tissue in birds. In birds, type 2 deiodinase is induced by low temperature exclusively in the liver, which appears to be caused by increased food consumption. We conclude that birds use low temperature-induced circulating T-3 not only for adaptive thermoregulation but also to trigger apoptosis to accelerate seasonal testicular regression.

    DOI： 10.1210/en.2014-1741

    Web of Science

    PubMed

    researchmap

  • Tissue-specific posttranslational modification allows functional targeting of thyrotropin. Reviewed

    Ikegami K, Liao XH, Hoshino Y, Ono H, Ota W, Ito Y, Nishiwaki-Ohkawa T, Sato C, Kitajima K, Iigo M, Shigeyoshi Y, Yamada M, Murata Y, Refetoff S, Yoshimura T

    Cell reports   9 ( 3 )   801 - 809   2014.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：CELL PRESS  

    Thyroid-stimulating hormone (TSH; thyrotropin) is a glycoprotein secreted from the pituitary gland. Pars distalis-derived TSH (PD-TSH) stimulates the thyroid gland to produce thyroid hormones (THs), whereas pars tuberalis-derived TSH (PT-TSH) actsonthe hypothalamus to regulate seasonal physiology and behavior. However, it had not been clear how these two TSHs avoid functional crosstalk. Here, we show that this regulation ismediated by tissue-specific glycosylation. Although PT-TSH is released into the circulation, it does not stimulate the thyroid gland. PD-TSH is known to have sulfated biantennary N-glycans, and sulfated TSH is rapidly metabolized in the liver. In contrast, PT-TSH has sialylated multibranched N-glycans; in the circulation, it forms the macro-TSH complex with immunoglobulin or albumin, resulting in the loss of its bioactivity. Glycosylation is fundamental to a wide range of biological processes. This report demonstrates its involvement in preventing functional crosstalk of signaling molecules in the body.

    DOI： 10.1016/j.celrep.2014.10.006

    Web of Science

    PubMed

    researchmap

  • Photoperiodism in vertebrates.

    Wataru Ota, Takashi Yoshimura

    Journal of the Society of Biomechanisms   35 ( 4 )   251 - 257   2011.11

    　More details

    Authorship：Lead author   Language：Japanese  

    DOI： 10.3951/sobim.35.251

    CiNii Books

    researchmap

▼display all

MISC

  • The 2016 Society for Research on Biological Rhythms meeting に参加して Invited

    太田 航

    学会誌「時間生物学」   22 ( 2 )   71 - 73   2016.11

    　More details

    Authorship：Lead author   Language：Japanese   Publishing type：Meeting report  

    File： The 2016 Society for Research on Biological Rhythms meeting に参加して.pdf

    researchmap

  • Functional analysis of tissue-specific post-translational modification of springtime hormone TSH

    IKEGAMI KEISUKE, LIAO XIAO-HUI, HOSHINO YUTA, ONO HIROKO, OTA WATARU, ITO YUKA, NISHIWAKI-OHKAWA TAEKO, SATO CHIHIRO, KITAJIMA KEN, IIGO MASAYUKI, SHIGEYOSHI YASUFUMI, YAMADA MASANOBU, MURATA YOSHIHARU, REFETOFF SAMUEL, YOSHIMURA TAKASHI

    時間生物学   20 ( 2 )   114   2014.10

    　More details

    Language：English  

    J-GLOBAL

    researchmap

  • ウズラの季節性精巣退縮における甲状腺ホルモンの機能解析

    IKEGAMI KEISUKE, ATSUMI YUSUKE, ONO HIROKO, MURAYAMA ITARU, NAKANE YUSUKE, OTA WATARU, ARAI NATSUMI, TEGA AKIMICHI, IIGO MASAYUKI, YOSHIMURA TAKASHI

    時間生物学   17 ( 2 )   144   2011.11

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • ウズラの季節性精巣退縮機構の解明

    ATSUMI YUSUKE, IKEGAMI KEISUKE, ONO HIROKO, MURAYAMA ITARU, NAKANE YUSUKE, OTA WATARU, ARAI NATSUMI, TEGA MEIRIN, IIGO MASAYUKI, YOSHIDA SHOSEI, YOSHIMURA TAKASHI

    J Reprod Dev   57 ( Suppl Japanese Issue )   J103 - j103   2011.8

    　More details

  • ウズラの季節性精巣退縮機構の解明

    IKEGAMI KEISUKE, ATSUMI YUSUKE, ONO HIROKO, MURAYAMA ITARU, NAKANE YUSUKE, OTA WATARU, ARAI NATSUMI, TEGA AKIMICHI, IIGO MASAYUKI, YOSHIDA SHOSEI, YOSHIMURA TAKASHI

    日本家禽学会誌大会号   48   2   2011.3

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • Mechanism of seasonal testicular regression in quail

    IKEGAMI KEISUKE, ATSUMI YUSUKE, ONO HIROKO, MURAYAMA ITARU, NAKANE YUSUKE, OTA WATARU, ARAI NATSUMI, TEGA AKINORI, IIGO MASAYUKI, YOSHIDA SHOSEI, YOSHIMURA TAKASHI

    比較生理生化学   28 ( Supplement )   224   2011

    　More details

    Language：English  

    J-GLOBAL

    researchmap

▼display all

Presentations

  • Identification of neural circuits responsible for manic-depressive mood swings in bipolar disorder

    Wataru Ota, Tomomi Yamanoue, Takuya Takahashi

    APPW2025 (The 130th Annual Meeting of the Japanese Association of Anatomists [JAA], The 102nd Annual Meeting of the Physiological Society of Japan [PSJ], The 98th Annual Meeting of the Japanese Pharmacological Society [JPS])  2025.3 

    　More details

    Event date： 2025.3

    Language：English   Presentation type：Oral presentation (general)  

    researchmap

  • Therapeutic effects of mood stabilizer (lithium) treatment in a mouse model of bipolar disorder with altered cerebellar synapses

    Wataru Ota, Tomomi Yamanoue, Takuya Takahashi

    2024.8 

    　More details

    Event date： 2024.8

    researchmap

  • Therapeutic effects of mood stabilizer (lithium) treatment in a mouse model of bipolar disorder with altered cerebellar synapses International conference

    Wataru Ota, Tomomi Yamanoue, Takuya Takahashi

    NEURO2024  2024.7 

    　More details

    Event date： 2024.7

    Language：English   Presentation type：Poster presentation  

    researchmap

  • Reduced AMPA receptors in the cerebellum induces bipolar mania via the ventral tegmental area International conference

    Wataru Ota, Takuya Takahashi

    The 35th World Congress Collegium Internationale Neuro-Psychopharmacologicum (CINP 2024), Joint Annual Meetings: The 54th Annual Meeting of the Japanese Society of Neuropsychopharmacology (JSNP 2024), The 34th Annual Meeting of the Japanese Society of Clinical Neuropsychopharmacology (JSCNP 2024)  2024.5  The International College of Neuropsychopharmacology (CINP)

    　More details

    Event date： 2024.5

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Tokyo   Country：Japan  

    researchmap

  • Lithium treatment rescued mania-like behavior in a synaptically modified mouse model of bipolar disorder

    Wataru Ota, Takuya Takahashi

    The 101st Annual Meeting of The Physiological Society of Japan  2024.3 

    　More details

    Event date： 2024.3

    Language：English   Presentation type：Poster presentation  

    researchmap

  • 概日リズム変容を伴う新規双極性障害（躁状態）モデルマウス

    太田 航, 山ノ上 友美, 佐野 亜加根, 高橋 琢哉

    Joint Congress of the 45th Annual Meeting of Japanese Society of Sleep Research, the 30th Annual Meeting of Japanese Society for Chronobiology  2023.9 

    　More details

    Event date： 2023.9

    Language：English   Presentation type：Poster presentation  

    researchmap

  • Downregulation of AMPA receptors in the cerebellum induces manic state in bipolar disorder via activation of the ventral tegmental area (VTA)

    Wataru Ota, Takuya Takahashi

    2023.8 

    　More details

    Event date： 2023.8 - 2023.9

    Language：English   Presentation type：Poster presentation  

    researchmap

  • Activation of the deep cerebellar nuclei (DCN)-ventral tegmental area (VTA) pathway induces mania-like behaviors in mice

    Wataru Ota, Tomomi Yamanoue, Takuya Takahashi

    The 46th Annual Meeting of the Japan Neuroscience Society  2023.8 

    　More details

    Event date： 2023.8

    Language：English   Presentation type：Oral presentation (general)  

    researchmap

  • Increased activity time (α) and activity fragmentation in a novel bipolar disorder (manic state) mouse model using a reverse translational approach

    Wataru Ota, Takuya Takahashi

    The 100th Anniversary Annual Meeting of The Physiological Society of Japan  2023.3 

    　More details

    Event date： 2023.3

    Language：English   Presentation type：Poster presentation  

    researchmap

  • A novel animal model of bipolar disorder using a reverse translational approach International conference

    Wataru Ota, Susumu Jitsuki, Tomomi Yamanoue, Tomoyuki Miyazaki, Waki Nakajima, Mai Hatano, Akane Sano, Hideaki Tani, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Masaru Mimura, Hiroyuki Uchida, Takuya Takahashi

    2022.8 

    　More details

    Event date： 2022.8

    Language：English   Presentation type：Poster presentation  

    Country：Japan  

    researchmap

  • A novel animal model of bipolar disorder using a reverse translational approach International conference

    Wataru Ota, Susumu Jitsuki, Tomomi Yamanoue, Tomoyuki Miyazaki, Waki Nakajima, Mai Hatano, Akane Sano, Hideaki Tani, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Masaru Mimura, Hiroyuki Uchida, Takuya Takahashi

    NEURO2022 (The 45th Annual Meeting of the Japan Neuroscience Society, The 65th Annual Meeting of the Japanese Society for Neurochemistry, The 32nd Annual Conference of the Japanese Neural Network Society)  2022.6 

    　More details

    Event date： 2022.6 - 2022.7

    Language：English   Presentation type：Poster presentation  

    Venue：Okinawa Convention Center   Country：Japan  

    researchmap

  • Reduction of cerebellar AMPA receptors induces bipolar mania-like behavior in mice

    Wataru Ota, Susumu Jitsuki, Tomomi Yamanoue, Tomoyuki Miyazaki, Waki Nakajima, Mai Hatano, Akane Sano, Hideaki Tani, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Masaru Mimura, Hiroyuki Uchida, Takuya Takahashi

    The 44th Annual Meeting of the Japan Neuroscience Society / The 1st CJK International Meeting  2021.7 

    　More details

    Event date： 2021.7

    Language：English   Presentation type：Poster presentation  

    researchmap

  • 哺乳類における新規光受容器Opsin5の発現解析

    OTA WATARU, NAKANE YUSUKE, IKEGAMI KEISUKE, YOSHIMURA TAKASHI

    日本畜産学会第115回大会  2012.3 

    　More details

    Language：Japanese  

    researchmap

  • 新規光受容器「オプシン5」欠損マウスの行動解析

    OTA WATARU, NAKANE YUSUKE, IKEGAMI KEISUKE, YOSHIMURA TAKASHI

    日本畜産学会第116回大会  2013.3 

    　More details

    Language：Japanese  

    researchmap

  • 哺乳類の網膜外光受容機構の解明

    Takashi Yoshimura, Wataru Ota

    最先端研究開発支援プログラム FIRST シンポジウム「科学技術が拓く2030年」へのシナリオ  2014.2 

    　More details

    Language：Japanese   Presentation type：Poster presentation  

    Venue：ベルサール新宿グランド  

    (Surrogate presentation)

    researchmap

  • Regulatory Mechanisms of Temporal Niche in Vertabrates International conference

    Wataru Ota, Takashi Yoshimura

    The 2nd International Symposium on Transformative Bio-Molecules 2014  2014.5  Institute of Transformative Bio-Molecules, Nagoya University

    　More details

    Language：English   Presentation type：Poster presentation  

    Venue：Nagoya University (Noyori Conference Hall)  

    researchmap

  • 温度刺激によるマウスの活動抑制現象について TRPチャネルの欠損が及ぼす影響 Invited

    Wataru Ota, Makiko Kashio, Makoto Tominaga, Takashi Yoshimura

    細胞センサーの分子機構・相互関連・ネットワーク研究会  2014.12  National Institute for Physiological Sciences

    　More details

    Presentation type：Oral presentation (invited, special)  

    researchmap

  • Search for the thermosensors involved in temperature-dependent negative masking behavior in mice.

    Wataru Ota, Makiko Kashio, Makoto Tominaga, Takashi Yoshimura

    The 22nd Annual Meeting of the Japanese Society for Chronobiology  2015.11 

    　More details

    Language：English   Presentation type：Oral presentation (invited, special)  

    Symposium 5 "Search for New Frontiers in Chronobilogy"

    researchmap

  • Search for the Thermosensors Involved in Temperature Dependent Negative Masking Behavior in Mice. International conference

    Wataru Ota, Makiko Kashio, Makoto Tominaga, Takashi Yoshimura

    The 64th NIBB Conference, Evolution of Seasonal Timers  2016.4 

    　More details

    Language：English   Presentation type：Poster presentation  

    researchmap

  • マウスの行動リズムにTRPチャネルの欠損が及ぼす影響

    OTA WATARU, KASHIO MAKIKO, TOMINAGA MAKOTO, YOSHIMURA TAKASHI

    日本畜産学会第119回大会  2015.3 

    　More details

    Language：Japanese  

    researchmap

  • Search for the thermosensors involved in temperature dependent negative masking behavior in mice. (Oral) Symposium 3: Temporal Niche International conference

    Wataru Ota, Makiko Kashio, Makoto Tominaga, Takashi Yoshimura

    XIV European Biological Rhythms Society (EBRS) and IV World Congress of Chronobiology (WCC) meeting  2015.8  European Biological Rhythms Society

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：UK (Manchester)  

    Symposium 3: Temporal Niche (Short Communications)

    researchmap

  • Search for the thermosensors involved in temperature dependent negative masking behavior in mice. (Poster) International conference

    Wataru Ota, Makiko Kashio, Makoto Tominaga, Takashi Yoshimura

    XIV European Biological Rhythms Society (EBRS) and IV World Congress of Chronobiology (WCC) meeting  2015.8  European Biological Rhythms Society

    　More details

    Language：English   Presentation type：Poster presentation  

    Venue：UK (Manchester)  

    Poster

    researchmap

  • Search for the thermosensors involved in temperature-dependent negative masking behavior in mice.

    Wataru Ota, Makiko Kashio, Makoto Tominaga, Takashi Yoshimura

    The 22nd Annual Meeting of the Japanese Society for Chronobiology  2015.11 

    　More details

    Language：English   Presentation type：Poster presentation  

    Poster

    researchmap

  • The photoresponses of Opn5-null mice.

    Wataru Ota, Yusuke Nakane, Takashi Yoshimura

    The 23rd Annual Meeting of the Japanese Society for Chronobiology  2016.11 

    　More details

    Language：English   Presentation type：Poster presentation  

    researchmap

  • Thermosensors and neural circuit regulating temperature-dependent negative masking behavior in mice.

    Wataru Ota, Yusuke Nakane, Makiko Kashio, Yoshiro Suzuki, Kazuhiro Nakamura, Yasuo Mori, Makoto Tominaga, Takashi Yoshimura

    The Nagoya Rhythm Collegium  2019.3 

    　More details

    Language：English   Presentation type：Poster presentation  

    researchmap

  • Thermosensors and neural circuit regulating temperature-dependent negative masking behavior in mice. International conference

    Wataru Ota, Yusuke Nakane, Makiko Kashio, Yoshiro Suzuki, Kazuhiro Nakamura, Yasuo Mori, Makoto Tominaga, Takashi Yoshimura

    9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS 2019) in conjunction with The 96th Annual Meeting of the Physiological Society of Japan  2019.3 

    　More details

    Language：English   Presentation type：Poster presentation  

    researchmap

  • Search for the Thermosensors Involved in Temperature Dependent Negative Masking Behavior in Mice. International conference

    Wataru Ota, Makiko Kashio, Makoto Tominaga, Takashi Yoshimura

    The 2016 Society for Research on Biological Rhythms meeting (SRBR 2016)  2016.5  Society for Research on Biological Rhythms

    　More details

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Innisbrook Resort, Palm Harbor, Florida  

    researchmap

  • Activation of the deep cerebellar nuclei (DCN)-ventral tegmental area (VTA) pathway induces mania-like behaviors in mice Invited

    Wataru Ota

    2024.6 

    　More details

    Language：English   Presentation type：Oral presentation (invited, special)  

    researchmap

▼display all

Awards

  • YCU Frontier Research Fellow

    2024.10   Yokohama City University  

    　More details

  • JAAS Fellow

    2024.8   Japanese Association for the Advancement of Science  

    　More details

  • 学術変革領域研究 (A) 【臨界期生物学】2023 年度 夏の領域班会議 優秀ポスター賞

    2023.9   Downregulation of AMPA receptors in the cerebellum induces manic state in bipolar disorder via activation of the ventral tegmental area (VTA)

    Wataru Ota

    　More details

  • JSC Best poster award

    2015.11   Japanese Society for Chronobiology (JSC)   Search for the thermosensors involved in temperature-dependent negative masking behavior in mice

    Wataru Ota

    　More details

    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

    researchmap

  • EBRS Poster Prizes

    2015.8   European Biological Rhythm Society (EBRS)   Search for the thermosensors involved in temperature dependent negative masking behavior in mice.

    Wataru Ota

    　More details

  • IGER Annual meeting 2013 Poster Award

    2014.1   Nagoya University Program for Leading Graduate Schools, Integrative Graduate Education and Research Program in Green Natural Sciences (IGER)   Regulatory mechanisms of temporal niche in vertebrates.

    Wataru Ota

    　More details

    Country：Japan

    researchmap

  • Repayment Exemption for Students Who Have Achieved an Especially Excellent Record

    2013.5   Japan Student Services Organization (JASSO)  

    Wataru Ota

    　More details

  • Excellent Presentation Award in the 116th annual meeting of Japanese Society of Animal Science

    2013.3   Japanese Society of Animal Science   Behavioral analyses of a novel photoreceptor "Opsin 5" null mice

    Wataru Ota

    　More details

    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

    researchmap

▼display all

Research Projects

  • Elucidation of the pathomechanisms of bipolar disorder through reverse translational manipulation of neuronal activity

    2025.4 - 2028.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    　 More details

    Authorship：Principal investigator 

    researchmap

  • 小脳シナプス変容新規疾患モデルマウスを用いた双極症発症メカニズムの解明

    2024.10 - 2026.3

    横浜市立大学  学長裁量事業 第 5 期 学術的研究推進事業「若手研究者支援プロジェクト」 

    太田 航

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    researchmap

  • ヒト脳機能画像（AMPA-PET）に基づくリバーストランスレーショナル研究による精神疾患発症機構の解明

    2024.8 - 2027.3

    横浜市立大学  学長裁量事業 第 6 期 戦略的研究推進事業 

    高橋 琢哉, 太田 航, 一條 貞満, 永露 毅, 有澤 哲

    　 More details

    Authorship：Coinvestigator(s) 

    researchmap

  • Effects of AMPA receptor levels in the brain on bipolar disorder, and its neural basis

    Grant number：21K15748  2021.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    　 More details

    Authorship：Principal investigator 

    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    researchmap

  • Mechanisms underlying aging and disease related circadian dysfunctions by in vivo Miniscope

    Grant number：20KK0229  2020.10 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    　 More details

    Authorship：Coinvestigator(s) 

    Grant amount：\18850000 （ Direct Cost: \14500000 、 Indirect Cost：\4350000 ）

    researchmap

  • Search for the thermosensors involved in temperature dependent negative masking behavior in mice.

    2015.8

    Nagoya University Program for Leading Graduate Schools, Integrative Graduate Education and Research Program in Green Natural Sciences (IGER)  Overseas Short-Term Travel Support 

    Wataru Ota

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\370568 （ Direct Cost: \370568 ）

    JPY 370,568

    researchmap

  • Regulatory Mechanisms of Temporal Niche in Vertebrates

    2014.4 - 2016.3

    Japan Society for the Promotion of Science (JSPS)  Grant-in-Aid for JSPS Fellows 

    Wataru Ota

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\2200000 （ Direct Cost: \2200000 ）

    JPY 2,200,000

    researchmap

  • Regulatory Mechanisms of Temporal Niche in Vertebrates

    2013.9 - 2014.3

    Nagoya University Program for Leading Graduate Schools, Integrative Graduate Education and Research Program in Green Natural Sciences (IGER)  Original Research Proposal 

    Wataru Ota

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\500000 （ Direct Cost: \500000 ）

    JPY 500,000

    researchmap

▼display all

Teaching Experience

  • Research Clerkship

    2023 Institution：Yokohama City University School of Medicine

    　More details

  • Science and Mathematics Master Training Program

    2023 Institution：Yokohama City University School of Medicine / School of Science

    　More details

  • Comprehensive Lectures "Medicine and Society"

    2022 Institution：Yokohama City University School of Medicine

    　More details

  • Post-CC OSCE

    2021 Institution：Yokohama City University School of Medicine

    　More details

  • Physiology practice

    2021 Institution：Yokohama City University School of Medicine

    　More details

  • Physiology

    2021 Institution：Yokohama City University School of Medicine

    　More details

▼display all

Social Activities

▼display all