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写真a

ナカムラ　タイシ
中村 大志
Taishi Nakamura
所属
附属市民総合医療センター 脳神経外科 助教
職名
助教
ホームページ
http://www-user.yokohama-cu.ac.jp/~nouge/
外部リンク

学位

  • 博士 （ 横浜市立大学 ）

研究キーワード

  • 脳神経外科

  • 脳腫瘍

  • 遺伝子解析

研究分野

  • ライフサイエンス / 脳神経外科学

経歴

  • 横浜市立大学 医学部医学科 脳神経外科学 医学研究科医科学専攻   助教

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論文

  • Preservation of nasal septal cartilage in endoscopic transsphenoidal approach surgery

    Taishi Nakamura, Yamato Oki, Kenta Fukui, Katsumi Sakata, Hiromitsu Hatakeyama, Tetsuya Yamamoto, Nobuhiko Oridate

    Interdisciplinary Neurosurgery   40   102050 - 102050   2025年6月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    DOI： 10.1016/j.inat.2025.102050

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  • Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors. 査読 国際誌

    Kohei Fukuoka, Yonehiro Kanemura, Tomoko Shofuda, Shintaro Fukushima, Satoshi Yamashita, Daichi Narushima, Mamoru Kato, Mai Honda-Kitahara, Hitoshi Ichikawa, Takashi Kohno, Atsushi Sasaki, Junko Hirato, Takanori Hirose, Takashi Komori, Kaishi Satomi, Akihiko Yoshida, Kai Yamasaki, Yoshiko Nakano, Ai Takada, Taishi Nakamura, Hirokazu Takami, Yuko Matsushita, Tomonari Suzuki, Hideo Nakamura, Keishi Makino, Yukihiko Sonoda, Ryuta Saito, Teiji Tominaga, Yasuhiro Matsusaka, Keiichi Kobayashi, Motoo Nagane, Takuya Furuta, Mitsutoshi Nakada, Yoshitaka Narita, Yuichi Hirose, Shigeo Ohba, Akira Wada, Katsuyoshi Shimizu, Kazuhiko Kurozumi, Isao Date, Junya Fukai, Yousuke Miyairi, Naoki Kagawa, Atsufumi Kawamura, Makiko Yoshida, Namiko Nishida, Takafumi Wataya, Masayoshi Yamaoka, Naohiro Tsuyuguchi, Takehiro Uda, Mayu Takahashi, Yoshiteru Nakano, Takuya Akai, Shuichi Izumoto, Masahiro Nonaka, Kazuhisa Yoshifuji, Yoshinori Kodama, Masayuki Mano, Tatsuya Ozawa, Vijay Ramaswamy, Michael D Taylor, Toshikazu Ushijima, Soichiro Shibui, Mami Yamasaki, Hajime Arai, Hiroaki Sakamoto, Ryo Nishikawa, Koichi Ichimura

    Acta neuropathologica communications   6 ( 1 )   134 - 134   2018年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Extensive molecular analyses of ependymal tumors have revealed that supratentorial and posterior fossa ependymomas have distinct molecular profiles and are likely to be different diseases. The presence of C11orf95-RELA fusion genes in a subset of supratentorial ependymomas (ST-EPN) indicated the existence of molecular subgroups. However, the pathogenesis of RELA fusion-negative ependymomas remains elusive. To investigate the molecular pathogenesis of these tumors and validate the molecular classification of ependymal tumors, we conducted thorough molecular analyses of 113 locally diagnosed ependymal tumors from 107 patients in the Japan Pediatric Molecular Neuro-Oncology Group. All tumors were histopathologically reviewed and 12 tumors were re-classified as non-ependymomas. A combination of RT-PCR, FISH, and RNA sequencing identified RELA fusion in 19 of 29 histologically verified ST-EPN cases, whereas another case was diagnosed as ependymoma RELA fusion-positive via the methylation classifier (68.9%). Among the 9 RELA fusion-negative ST-EPN cases, either the YAP1 fusion, BCOR tandem duplication, EP300-BCORL1 fusion, or FOXO1-STK24 fusion was detected in single cases. Methylation classification did not identify a consistent molecular class within this group. Genome-wide methylation profiling successfully sub-classified posterior fossa ependymoma (PF-EPN) into PF-EPN-A (PFA) and PF-EPN-B (PFB). A multivariate analysis using Cox regression confirmed that PFA was the sole molecular marker which was independently associated with patient survival. A clinically applicable pyrosequencing assay was developed to determine the PFB subgroup with 100% specificity using the methylation status of 3 genes, CRIP1, DRD4 and LBX2. Our results emphasized the significance of molecular classification in the diagnosis of ependymomas. RELA fusion-negative ST-EPN appear to be a heterogeneous group of tumors that do not fall into any of the existing molecular subgroups and are unlikely to form a single category.

    DOI： 10.1186/s40478-018-0630-1

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  • [Cryptococcal Meningitis in a Patient with Breast Cancer Receiving Everolimus: A Case of Successful Treatment with Continuous Cerebrospinal Fluid Drainage]. 査読

    Takase K, Yoshida T, Nakamura T, Seki S, Sato H, Yamamoto T

    Brain and nerve = Shinkei kenkyu no shinpo   70 ( 11 )   1301 - 1305   2018年11月

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.11477/mf.1416201178

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  • [Efficacy and Safety of Salvage ESHAP Chemotherapy for Recurrent/Refractory PCNSLs]. 査読

    Nagao K, Nakamura T, Tateishi K, Sato H, Shimizu N, Suenaga J, Murata H, Kanno H, Yamamoto T

    No shinkei geka. Neurological surgery   46 ( 7 )   575 - 581   2018年7月

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.11477/mf.1436203773

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  • Distinct molecular profile of diffuse cerebellar gliomas 査読

    Masashi Nomura, Akitake Mukasa, Genta Nagae, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Shiro Fukuda, Takayoshi Umeda, Tomonari Suzuki, Ryohei Otani, Keiichi Kobayashi, Takashi Maruyama, Shota Tanaka, Shunsaku Takayanagi, Takahide Nejo, Satoshi Takahashi, Koichi Ichimura, Taishi Nakamura, Yoshihiro Muragaki, Yoshitaka Narita, Motoo Nagane, Keisuke Ueki, Ryo Nishikawa, Junji Shibahara, Hiroyuki Aburatani, Nobuhito Saito

    ACTA NEUROPATHOLOGICA   134 ( 6 )   941 - 956   2017年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s00401-017-1771-1

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  • Prevention of PKG1α oxidation augments cardioprotection in the stressed heart. 査読

    Nakamura T, Ranek MJ, Lee DI, Shalkey Hahn V, Kim C, Eaton P, Kass DA

    The Journal of clinical investigation   125 ( 6 )   2468 - 2472   2015年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1172/JCI80275

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  • Soluble Guanylate Cyclase Is Required for Systemic Vasodilation But Not Positive Inotropy Induced by Nitroxyl in the Mouse 査読

    Guangshuo Zhu, Dieter Groneberg, Gautam Sikka, Daijiro Hori, Mark J. Ranek, Taishi Nakamura, Eiki Takimoto, Nazareno Paolocci, Dan E. Berkowitz, Andreas Friebe, David A. Kass

    HYPERTENSION   65 ( 2 )   385 - U290   2015年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1161/HYPERTENSIONAHA.114.04285

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  • Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling 査読

    Manling Zhang, Eiki Takimoto, Dong-ik Lee, Celio X. C. Santos, Taishi Nakamura, Steven Hsu, Aiyang Jiang, Takahiro Nagayama, Djahida Bedja, Yuan Yuan, Philip Eaton, Ajay M. Shah, David A. Kass

    CIRCULATION   126 ( 8 )   942 - U96   2012年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1161/CIRCULATIONAHA.112.090977

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  • Amlodipine Enhances Amelioration of Vascular Insulin Resistance, Oxidative Stress, and Metabolic Disorders by Candesartan in Metabolic Syndrome Rats 査読

    Daisuke Sueta, Taishi Nakamura, Yi-Fei Dong, Keiichiro Kataoka, Nobutaka Koibuchi, Eiichiro Yamamoto, Kensuke Toyama, Osamu Yasuda, Hisao Ogawa, Shokei Kim-Mitsuyama

    AMERICAN JOURNAL OF HYPERTENSION   25 ( 6 )   704 - 710   2012年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/ajh.2012.26

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  • A Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improves Endothelial Function and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice 査読

    Junichi Matsubara, Seigo Sugiyama, Koichi Sugamura, Taishi Nakamura, Yukio Fujiwara, Eiichi Akiyama, Hirofumi Kurokawa, Toshimitsu Nozaki, Keisuke Ohba, Masaaki Konishi, Hirofumi Maeda, Yasuhiro Izumiya, Koichi Kaikita, Hitoshi Sumida, Hideaki Jinnouchi, Kunihiko Matsui, Shokei Kim-Mitsuyama, Motohiro Takeya, Hisao Ogawa

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   59 ( 3 )   265 - 276   2012年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.jacc.2011.07.053

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  • Passive Exercise Using Whole-Body Periodic Acceleration Enhances Blood Supply to Ischemic Hindlimb 査読

    Taku Rokutanda, Yasuhiro Izumiya, Mitsutoshi Miura, Shota Fukuda, Kenei Shimada, Yasukatsu Izumi, Yasuhiro Nakamura, Satoshi Araki, Shinsuke Hanatani, Junichi Matsubara, Taishi Nakamura, Keiichiro Kataoka, Osamu Yasuda, Koichi Kaikita, Seigo Sugiyama, Shokei Kim-Mitsuyama, Junichi Yoshikawa, Masatoshi Fujita, Minoru Yoshiyama, Hisao Ogawa

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   31 ( 12 )   2872 - U308   2011年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1161/ATVBAHA.111.229773

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  • Beneficial Effects of Combination of Valsartan and Amlodipine on Salt-Induced Brain Injury in Hypertensive Rats 査読

    Yi-Fei Dong, Keiichiro Kataoka, Yoshiko Tokutomi, Hisato Nako, Taishi Nakamura, Kensuke Toyama, Daisuke Sueta, Nobutaka Koibuchi, Eiichiro Yamamoto, Hisao Ogawa, Shokei Kim-Mitsuyama

    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   339 ( 2 )   358 - 366   2011年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1124/jpet.111.182576

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  • Novel mechanism of salt-induced glomerular injury: critical role of eNOS and angiotensin II 査読

    Taishi Nakamura, Keiichiro Kataoka, Yoshiko Tokutomi, Hisato Nako, Kensuke Toyama, Yi-Fei Dong, Nobutaka Koibuchi, Eiichiro Yamamoto, Osamu Yasuda, Hisao Ogawa, Shokei Kim-Mitsuyama

    JOURNAL OF HYPERTENSION   29 ( 8 )   1528 - 1535   2011年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1097/HJH.0b013e328348ca95

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  • Eplerenone potentiates protective effects of amlodipine against cardiovascular injury in salt-sensitive hypertensive rats 査読

    Taishi Nakamura, Masaya Fukuda, Keiichiro Kataoka, Hisato Nako, Yoshiko Tokutomi, Yi-Fei Dong, Eiichiro Yamamoto, Osamu Yasuda, Hisao Ogawa, Shokei Kim-Mitsuyama

    HYPERTENSION RESEARCH   34 ( 7 )   817 - 824   2011年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/hr.2011.35

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