Updated on 2025/09/01

写真a

 
Tomo Nozawa
 
Organization
Graduate School of Medicine Department of Medicine Pediatrics Lecturer
School of Medicine Medical Course
Title
Lecturer
Profile

小児リウマチ性疾患で用いられるステロイド、生物学的製剤および免疫抑制薬使用患者における結核を含めた特殊感染症の発症リスクの検討を行った。小児リウマチ性疾患の長期縦断研究に取り組んでいる。

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Degree

  • 博士(医学) ( 2018.4   横浜市立大学 )

Research Interests

  • 小児

  • 免疫・アレルギー・膠原病学

Research Areas

  • Life Science / Embryonic medicine and pediatrics

Education

  • Hirosaki University   School of Medicine   Medicine

    1999.4 - 2005.3

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    Country: Japan

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Research History

  • Graduate School of Medicine, Yokohama City University   Department of Pediatrics   Lecturer

    2023.4

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    Country:Japan

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  • Graduate School of Medicine, Yokohama City University   Department of Pediatrics   Assistant Professor

    2020.4 - 2023.3

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  • The Hospital for Sick Children   Division of Rheumatology   Research Fellow

    2018.4 - 2020.3

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    Country:Canada

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  • Graduate School of Medicine, Yokohama City University   Department of Pediatrics   Assistant Professor

    2017.4 - 2018.3

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  • Yokohama City University Hospital   Department of Pediatrics,   Assistant Professor

    2016.4 - 2017.3

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  • Graduate School of Medicine, Yokohama City University   Department of Pediatrics   Assistant Professor

    2015.4 - 2016.3

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  • Yokohama City University   Department of pediatrics   Staff

    2010.4 - 2015.3

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  • National Hospital Organization, Yokohama Medical Center   Department of Pediatrics   Staff

    2008.10 - 2010.3

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  • Yokohama City University Hospital   Department of Dermatology   Clinical Fellow

    2007.10 - 2008.3

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  • Yokohama City University Hospital   Department of Pediatrics   Clinical Fellow

    2007.4 - 2007.9

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  • Iwate Prefectural Central Hospital   Resident

    2005.4 - 2007.3

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Professional Memberships

  • JAPAN PEDIATRIC SOCIETY

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  • JAPANESE SOCIETY OF ALLERGOLOGY

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  • JAPAN COLLEGE OF RHEUMATOLOGY

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  • PEDIATRIC RHEUMATOLOGY ASSOCIATION OF JAPAN

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  • THE JAPANESE ASSOCIATION FOR INFECTIOUS DISEASES

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  • JAPANESE SOCIETY FOR PEDIATRIC INFECTIOUS DISEASES

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  • JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY

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  • JAPANESE SOCIETY FOR TUBERCULOSIS

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  • THE JAPAN SOCIETY FOR CLINICAL IMMUNOLOGY

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Papers

  • Correction: Safety and effectiveness of intravenous abatacept for polyarticular-course juvenile idiopathic arthritis: An all-case postmarketing surveillance study. International journal

    Tomo Nozawa, Naomi Iwata, Toru Igarashi, Ichiro Kobayashi, Shoji Ota, Takako Yamada, Etsuya Bando, Katsuyoshi Habiro, Syuji Takei

    Pediatric rheumatology online journal   23 ( 1 )   25 - 25   2025.3

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  • Safety and effectiveness of intravenous abatacept for polyarticular-course juvenile idiopathic arthritis: An all-case postmarketing surveillance study. Reviewed International journal

    Tomo Nozawa, Naomi Iwata, Toru Igarashi, Ichiro Kobayashi, Shoji Ota, Takako Yamada, Etsuya Bando, Katsuyoshi Habiro, Syuji Takei

    Pediatric rheumatology online journal   23 ( 1 )   19 - 19   2025.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: In 2018, intravenous abatacept was approved for the treatment of refractory polyarticular-course juvenile idiopathic arthritis (JIA) in Japan. However, reports describing the effectiveness and safety of abatacept in clinical practice in Japanese patients with refractory polyarticular-course JIA are limited. Therefore, this postmarketing surveillance study aimed to evaluate the real-world safety and effectiveness of abatacept in Japanese pediatric patients with refractory polyarticular-course JIA. METHODS: This study evaluated patients included in an all-case postmarketing surveillance study between February 2018 and August 2020 who were treated with intravenous abatacept. Data on the safety and effectiveness of the registered patients were collected during the 52-week follow-up period. Disease activities were evaluated using Juvenile Arthritis Disease Activity Score 27 (JADAS-27). The effect of abatacept on a child's growth was assessed using the height and weight standard deviation scores (SDS). RESULTS: A total of 82 patients were registered in this study, of whom 14.6% and 85.4% were males and females, respectively. The proportion of patients with oligoarticular, rheumatoid factor (RF)-negative polyarticular, and RF-positive polyarticular JIA was 12.2, 28.0, and 54.9%, respectively. The incidence of adverse drug reactions (ADRs) and serious ADRs was 22.0% and 2.4%, respectively. During the study period, 64.7% of the patients achieved JADAS-27 low disease activity or less. A significant difference in JADAS-27 scores in patients with RF-positive polyarticular JIA was observed between baseline and 24 or 52 weeks after abatacept administration. The height and weight SDS tended to improve during abatacept treatment. CONCLUSIONS: Abatacept is effective in polyarticular-course JIA, particularly in RF-positive patients, and in restoring a child's growth. Additionally, the incidence of ADRs is similar to that observed in the clinical trial. The results of the study suggest that abatacept is a useful therapeutic option for treating refractory polyarticular-course JIA in real-world settings in Japan.

    DOI: 10.1186/s12969-025-01069-4

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  • Intolerance of oral methotrexate in juvenile idiopathic arthritis. Reviewed International journal

    Ai Yuda, Tomo Nozawa, Seira Hattori, Ayako Murase, Kenichi Nishimura, Ryoki Hara, Shuichi Ito

    Pediatrics international : official journal of the Japan Pediatric Society   67 ( 1 )   e70112   2025

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    BACKGROUND: Oral methotrexate (MTX) is a cornerstone treatment for juvenile idiopathic arthritis (JIA), although adverse events (AEs) such as nausea and vomiting often impact adherence. This study examined the intolerability of MTX in patients with JIA. METHODS: We retrospectively investigated MTX intolerability in 52 patients treated at our institute between April 2011 and October 2022. The target MTX dose was 10 mg/m2/week (maximum 16 mg/week) according to the Japanese clinical guidelines for JIA. RESULTS: The median age at MTX initiation was 8.3 years, with a median maximum dose of 8.9 mg/m2/week. Of the 52 patients, 16 (31%) were started on biologics before or at the initiation of MTX, while 36 (69%) began MTX monotherapy. Fifteen (29%) patients could not reach the target MTX dose because of AEs. Thirty-six (68%) patients experienced one or more AEs, with nausea and vomiting being the most common (n = 24). Eleven patients (21%) failed to achieve or maintain remission because of intractable nausea/vomiting, and nine (17%) eventually required biologics. Among the 24 patients who experienced nausea/vomiting, 42% developed symptoms within 6 months and 67% within 12 months of MTX initiation. AEs occurred regardless of MTX dose. CONCLUSIONS: Two-thirds of patients experienced AEs with oral MTX, leading some to fail remission and require biologics. Intolerability of oral MTX was common and significantly influenced patient outcomes.

    DOI: 10.1111/ped.70112

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  • Evaluation of Medication Withdrawal in Patients with Non-systemic Juvenile Idiopathic Arthritis in Japan Using a Web-based Survey. Reviewed International journal

    Takasuke Ebato, Takayuki Kishi, Keiji Akamine, Tomo Nozawa, Tomoyuki Imagawa, Yuki Bando, Takako Miyamae

    Modern rheumatology   2024.3

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    OBJECTIVE: Although treatments for juvenile idiopathic arthritis (JIA) have seen considerable advancements, there remains a lack of clear guidelines on withdrawing medications. This study aimed to investigate the current strategies for discontinuing non-systemic JIA treatment. METHODS: A web-based questionnaire was distributed to Pediatric Rheumatology Association of Japan members. RESULTS: According to 126 responses, the most significant factors influencing JIA treatment tapering were the duration of clinically inactive disease, medication toxicity, and a history of arthritis flares. Respondents were often cautious about discontinuing medication if symptoms, e.g., 'morning stiffness' or 'intermittent joint pain', persisted. Among subtypes, oligoarticular JIA was more amenable to treatment tapering, whereas rheumatoid factor-positive polyarticular JIA proved less amenable. Most respondents started medication tapering after a continuous clinical inactive duration exceeding 12 months, and >50% of them required >6 months to achieve treatment discontinuation. Additionally, 40% of respondents consistently underwent imaging before treatment tapering. CONCLUSIONS: The relative risks of treatment continuation and withdrawal should be considered, and decisions should be made accordingly. To obtain improved understanding of and more robust evidence for the optimal strategies for safely discontinuing JIA treatment, it is crucial to continue investigations, including long-term outcomes.

    DOI: 10.1093/mr/roae016

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  • Clinical characteristics of cryopyrin-associated periodic syndrome and long-term real-world efficacy and tolerability of canakinumab in Japan: results of a nationwide survey. Reviewed International journal

    Takayuki Miyamoto, Kazushi Izawa, Sho Masui, Atsue Yamazaki, Yuichi Yamasaki, Tadashi Matsubayashi, Mayuka Shiraki, Hidenori Ohnishi, Junko Yasumura, Kawabe Tomohiro, Takako Miyamae, Tomoyo Matsubara, Naoya Arakawa, Takashi Ishige, Takumi Takizawa, Asami Shimbo, Masaki Shimizu, Naoki Kimura, Yuichi Maeda, Yuta Maruyama, Tomonari Shigemura, Junichi Furuta, Satoshi Sato, Hiroshi Tanaka, Miharu Izumikawa, Masahiro Yamamura, Toshio Hasegawa, Hiroshi Kaneko, Yasuo Nakagishi, Naoko Nakano, Yasunori Iida, Tamaki Nakamura, Hiroyuki Wakiguchi, Takayuki Hoshina, Toshinao Kawai, Kosaku Murakami, Shuji Akizuki, Akio Morinobu, Koichiro Ohmura, Katsuhide Eguchi, Motoshi Sonoda, Masataka Ishimura, Kenji Furuno, Momoko Kashiwado, Masaaki Mori, Kimito Kawahata, Koremasa Hayama, Kumiko Shimoyama, Natsuko Sasaki, Taisuke Ito, Hiroaki Umebayashi, Tae Omori, Seiko Nakamichi, Tomotsune Dohmoto, Yasuyuki Hasegawa, Hisashi Kawashima, Shojiro Watanabe, Yuichiro Taguchi, Haruna Nakaseko, Naomi Iwata, Hiroki Kohno, Taiki Ando, Yasuhiko Ito, Yuko Kataoka, Takako Saeki, Utako Kaneko, Ayako Murase, Seira Hattori, Tomo Nozawa, Kenichi Nishimura, Reiji Nakano, Misa Watanabe, Masato Yashiro, Tomonori Nakamura, Toshihiko Komai, Kentaro Kato, Yoshitaka Honda, Eitaro Hiejima, Atsushi Yonezawa, Kazuhisa Bessho, Satoshi Okada, Osamu Ohara, Junko Takita, Takahiro Yasumi, Ryuta Nishikomori

    Arthritis & rheumatology (Hoboken, N.J.)   2024.1

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    OBJECTIVE: To assess the clinical characteristics of patients with cryopyrin-associated periodic syndrome (CAPS) in Japan and evaluate the real-world efficacy and safety of interleukin (IL)-1 inhibitors, primarily canakinumab. METHODS: Clinical information was collected retrospectively, and serum concentrations of canakinumab and cytokines were analyzed. RESULTS: One-hundred-and-one patients were included, with 86 and 15 carrying heterozygous germline and somatic mosaic mutations, respectively. We identified 39 mutation types, and the common CAPS-associated symptoms corresponded with those in previous reports. Six patients (5.9% of all patients) died, with four of the deaths caused by CAPS-associated symptoms. Notably, 73.7% of patients (100, 79.6, and 44.4% of familial cold autoinflammatory syndrome: FCAS, Muckle-Wells syndrome (MWS), and chronic infantile neurological cutaneous articular syndrome/neonatal onset multisystem inflammatory disease (CINCA/NOMID), respectively) achieved complete remission with canakinumab, and early therapeutic intervention was associated with better auditory outcomes. In some patients, canakinumab treatment stabilized the progression of epiphysial overgrowth and improved height gain, visual acuity, and renal function. However, 23.7% of patients did not achieve inflammatory remission with crucial deterioration of organ damage, with two dying while receiving high-dose canakinumab treatment. Serological analysis of canakinumab and cytokine concentrations revealed that the poor response was not related to canakinumab shortage. Four inflammatory non-remitters developed inflammatory bowel disease unclassified during canakinumab treatment. Dual biologic therapy with canakinumab and anti- tumor necrosis factor-α agents was effective for IBD- and CAPS-associated symptoms not resolved by canakinumab monotherapy. CONCLUSIONS: This study provides one of the largest epidemiologic datasets for CAPS. While early initiation of anti-IL-1 treatment with canakinumab is beneficial for improving disease prognosis, some patients do not achieve remission despite a high serum concentration of canakinumab. Moreover, IBD may develop in CAPS following canakinumab treatment.

    DOI: 10.1002/art.42808

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  • Disease activity trajectories in juvenile dermatomyositis from childhood to adulthood. Reviewed International journal

    Tomo Nozawa, Eleanor M Pullenayegum, Audrey Bell-Peter, Jo-Anne Marcuz, Kristi Whitney, Ophir Vinik, Rachel Shupak, Saunya Dover, Brian M Feldman

    Rheumatology (Oxford, England)   2024.1

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    OBJECTIVES: To assess whether there are identifiable subgroups of disease activity trajectory in a population of juvenile dermatomyositis (JDM) patients-followed throughout childhood and into adulthood-and determine factors that predict those trajectory groupings. METHODS: This is a retrospective, longitudinal inception cohort of patients with idiopathic inflammatory myopathies, largely JDM. We sought to identify baseline factors that predict membership into different groups (latent classes) of disease activity trajectory. RESULTS: A total of 172 patients (64% females), with median age at diagnosis of 7.7 years, were analyzed. We studied 4,725 visits (1,471 patient-years). We identified 3 latent classes of longitudinal disease activity, as measured by the modified disease activity score (DASm), with distinct class trajectories predicted by DASm at baseline, and by the changes of DASm from either baseline to 3 months or baseline to 6 months (early response to therapy). In the analysis in which DASm at baseline and the changes of DASm from baseline to 6 months are included as predictors, Class 1 (10%) has persistently high disease activity, Class 2 (34%) is characterized by moderate disease activity, and Class 3 (56%) is characterized by individuals with a high early disease activity but an apparently good response to treatment and long-term low disease activity. CONCLUSION: High early disease activity, and treatment resistance in the first few months, predict a more chronic longitudinal course of JDM.

    DOI: 10.1093/rheumatology/keae027

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  • Characteristics of persistent arthritis with refractory Kawasaki disease: a single-center retrospective study. Reviewed International journal

    Seira Hattori, Tomo Nozawa, Kenichi Nishimura, Ryoki Hara, Ayako Murase, Asami Ohara, Ai Ohnishi, Takashi Ohya, Shuichi Ito

    Scientific reports   13 ( 1 )   9890 - 9890   2023.6

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    Arthritis is one complication of Kawasaki disease (KD); however, the clinical features of arthritis in KD have not been well clarified. We retrospectively investigated the characteristics of persistent arthritis beyond the subacute phase of KD. In this cohort, 49 of 243 patients (20%) developed arthritis, with 33 patients (14%) experiencing persistent arthritis. Among these 33 patients, 31 (94%) had complete KD. Thirty (91%) were resistant to first intravenous immunoglobulin, and 15 (45%) required additional infliximab. Five patients (15%) developed coronary artery lesions, and 24 (73%) had oligoarthritis, mainly in large lower-extremity joints. Twenty-four patients (73%) complained of arthralgia. At arthritis onset, 16 patients (48%) presented with fever, including recurrent fever in 10 patients. Serum C-reactive protein concentration in patients with active arthritis significantly increased compared with after acute KD treatment (2.4 vs. 0.7 mg/dL, p < 0.001). Serum matrix metalloproteinase-3, a biomarker of arthritis, was significantly higher in patients with active arthritis than in remission (93.7 vs. 20.3 ng/mL, p < 0.001). Thirty (91%) and 14 (42%) patients, respectively, were treated with non-steroidal anti-inflammatory drugs and prednisolone, and they completely recovered. To summarize, persistent arthritis is a common complication in refractory KD, and adequate diagnosis and treatment are necessary.

    DOI: 10.1038/s41598-023-36308-9

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  • Purple eyelid sign in multisystem inflammatory syndrome in children (MIS-C). Reviewed International journal

    Yosuke Komatsu, Tomo Nozawa, Yuji Kamiyama, Seira Hattori, Kenichi Nishimura, Shuichi Ito

    Pediatrics international : official journal of the Japan Pediatric Society   65 ( 1 )   e15510   2023.2

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    DOI: 10.1111/ped.15510

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  • The clinical features of juvenile dermatomyositis: A single-centre inception cohort. Reviewed International journal

    Paola Cancarini, Tomo Nozawa, Kristi Whitney, Audrey Bell-Peter, Jo-Anne Marcuz, Andrea Taddio, Jessica Guo, Saunya Dover, Brian M Feldman

    Seminars in arthritis and rheumatism   57   152104 - 152104   2022.9

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    INTRODUCTION: Juvenile Dermatomyositis (JDM), a severe and rare autoimmune disease, is the most common idiopathic inflammatory myopathy in children. We describe the clinical features of a large single-centre cohort. METHODS: We studied an inception cohort (0-18 years old) referred for diagnosis to the JDM clinic at The Hospital for Sick Children (SickKids), between January 1989 and September 2017. Probable or definite diagnosis of JDM was done according to the 2017 ACR/EULAR Criteria. We excluded children who had treatment started at another hospital. The data were collected retrospectively from clinical charts and the SickKids JDM database. RESULTS: 172/230 (74.8%) patients were included. They were most often female (female:male = 1.8:1); the age at diagnosis was 8.5±4.3 years. There was a positive family history for autoimmune disease in 52%, mainly rheumatoid arthritis. No patient died. The most common signs at inception were muscle weakness (85.5%), nailfold capillary abnormalities (83.4%), Gottron papules (78.5%), heliotrope rash (66.3%), abnormal gait (55.8%), and malar/facial rash (54.7%). The prevalence of Gottron papules, heliotrope rash, facial/malar rash, nailfold capillary abnormalities, Raynaud phenomenon, dysphonia/dysphagia (a frequent cause of hospitalization), mouth ulcers, calcinosis, eye problems, joint involvement, acanthosis nigricans and lipodystrophy increased during follow-up. Muscle enzymes, namely CK, ALT, AST, were often normal or only slightly raised despite active muscle disease; conversely LD was often high. Anti-Nuclear Autoantibodies were positive in 49.7% of patients at diagnosis. The course of the disease was: 29.1% monocyclic, 5.3% polycyclic, 33.1% chronic. The course of 56 patients (32.5%) was not classifiable due to length of follow-up. Corticosteroids were used as treatment in almost all our patients and 30% required intravenous therapy due to the severity of the presentation; methotrexate was added in 64%, more often in recent years. Unresponsive patients were treated mostly with intravenous immunoglobulins (IVIG). CONCLUSIONS: The information obtained from this relatively large number of patients adds to the growing knowledge base of this rare disease. TRIAL REGISTRATION: SickKids Research Ethics Board approved the study.

    DOI: 10.1016/j.semarthrit.2022.152104

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  • Epidemiology conduction of paediatric rheumatic diseases based on the registry database of the Pediatric Rheumatology Association of Japan. Reviewed International journal

    Hidehiko Narazaki, Shinji Akioka, Yuko Akutsu, Mariko Araki, Mikiya Fujieda, Daisuke Fukuhara, Ryoki Hara, Kunio Hashimoto, Seira Hattori, Ren Hayashibe, Tomoyuki Imagawa, Yuzaburo Inoue, Hiroyuki Ishida, Shuici Ito, Yasuhiko Itoh, Tomohiro Kawabe, Toshiyuki Kitoh, Ichiro Kobayashi, Tadashi Matsubayashi, Takako Miyamae, Mao Mizuta, Masaaki Mori, Ayako Murase, Yasuo Nakagishi, Koji Nagatani, Naoko Nakano, Toyoki Nishimura, Tomo Nozawa, Nami Okamoto, Yuka Okura, Hiromi Sawada, Emi Sawanobori, Yuko Sugita, Yujiro Tanabe, Minako Tomiita, Ken-Ichi Yamaguchi, Ryuhei Yasuoka, Koji Yokoyama

    Modern rheumatology   33 ( 5 )   1021 - 1029   2022.9

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    OBJECTIVES: Although epidemiological surveys of paediatric rheumatic diseases in Japan have been conducted they were single surveys with no continuity. This is the first report of the Pediatric Rheumatology Association of Japan (PRAJ) registry database, which was established to continuously collect data for paediatric rheumatic diseases. METHODS: 'PRICUREv2' (Pediatric Rheumatology International Collaborate Unit Registry version 2) is a registry database established by the PRAJ. The registry data were analysed for the age of onset, time to diagnosis, sex differences, seasonality, and other factors. RESULTS: Our data showed the same trend regarding rates of paediatric rheumatic diseases reported in Japan and other countries. The age of onset was lower in juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM) and higher in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). The time to diagnosis was relatively short in JIA and SLE but longer in JDM and SS. Rheumatoid factor-positive polyarticular JIA showed a seasonality cluster with regard to onset. CONCLUSION: PRICUREv2 aided the retrieval and evaluation of current epidemiological information on patients with paediatric rheumatic diseases. It is expected that the data collection will be continued and will be useful for expanding research in Japan.

    DOI: 10.1093/mr/roac112

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  • Early abnormal nailfold capillary changes are predictive of calcinosis development in juvenile dermatomyositis. Reviewed International journal

    Tomo Nozawa, Audrey Bell-Peter, Jo-Anne Marcuz, Kristi Whitney, Ophir Vinik, Rachel Shupak, Saunya Dover, Brian M Feldman

    The Journal of rheumatology   2022.8

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    OBJECTIVE: The long-term outcomes of juvenile dermatomyositis (JDM) are more favorable in recent years. However, calcinosis is still among the complications that can cause serious functional impairment. Little is known about the pathogenesis and risk factors of calcinosis. The aim of this study is to determine risk factors for the development of calcinosis in JDM. METHODS: This was a single-center, retrospective cohort study. All patients were diagnosed and followed at The Hospital for Sick Children's multidisciplinary JDM clinic, from January 1, 1989 until May 31, 2018. To investigate predictors of incident calcinosis, Cox regression analysis was performed. RESULTS: A total of 172 patients met inclusion criteria, median age at diagnosis of 7.7 years (interquartile range [IQR] 4.9-12.1), median follow-up of 8.5 years (IQR 8.5-12.6, range 0.13-28.3). The only risk factor significantly associated with the development of calcinosis in the univariate analysis was nailfold abnormality at baseline (hazard ratio [HR] 4.857, p = 0.029), and the other variables had no significant relationship with calcinosis. In multivariable analysis, including nailfold abnormality, age of diagnosis, sex, and duration from onset to diagnosis, the only statistically significant risk factor for calcinosis was the presence of nailfold abnormalities (HR 4.975, p = 0.027). Furthermore, calcinosis was significantly increased in patients with a chronic course (chi-square 25.8, p = 0.00001). CONCLUSION: The presence of abnormal nailfold capillary changes at baseline is predictive for the development of calcinosis in children with idiopathic inflammatory myopathies.

    DOI: 10.3899/jrheum.220249

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  • Difficulties of Diagnosing Idiopathic Hypertrophic Pachymeningitis in Children: Case Report and Literature Review. Reviewed International journal

    Naoki Nicho, Tomo Nozawa, Ayako Murase, Ren Hayashibe, Reo Tanoshima, Risa Okubo, Seira Hattori, Kenichi Nishimura, Takashi Ohya, Shuichi Ito

    Modern rheumatology case reports   7 ( 1 )   233 - 236   2022.3

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    Hypertrophic pachymeningitis (HP) is a rare inflammatory disorder characterized by local or diffuse thickening of the cranial and spinal dura mater. HP occurs owing to idiopathic or secondary causes, including autoimmune disease, infection, and trauma. HP has mainly been reported in adults, with few reported cases in children. We encountered an 11-year-old boy with idiopathic HP who presented with chronic inflammation and daily occipital headache. Gadolinium (Gd)-enhanced magnetic resonance imaging (MRI) helped us to diagnose him with HP. He was successfully treated with corticosteroids and azathioprine with no recurrence. We also conducted a literature review of childhood-onset HP and found only 16 cases including our patient. Seven patients had idiopathic HP and the remaining nine had secondary HP, including two with rheumatic disease. The most common clinical symptoms were headache (68.8%) and cranial nerve-related symptoms (68.8%). Inflammatory laboratory markers were elevated in 60% of patients with available data. Fifteen cases were diagnosed using Gd-enhanced MRI. The main initial treatment was steroids and/or immunosuppressants, to which 87.5% of patients responded. However, two patients with HP associated with trauma and neuroblastoma (12.5%) died, and seven patients (43.8%) had left cranial nerve-related sequelae. As the prognosis for childhood HP is poor, early diagnosis and treatment are essential. Children with headache, cranial nerve symptoms, and elevated inflammatory marker levels should be suspected of having HP and Gd-enhanced MRI should be considered.

    DOI: 10.1093/mrcr/rxac026

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  • Impaired Interleukin-18 Signaling in Natural Killer Cells From Patients With Systemic Juvenile Idiopathic Arthritis. Reviewed International journal

    Takashi Ohya, Kenichi Nishimura, Ayako Murase, Seira Hattori, Asami Ohara, Tomo Nozawa, Ryoki Hara, Shuichi Ito

    ACR open rheumatology   2022.3

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    OBJECTIVE: Systemic juvenile idiopathic arthritis (sJIA) is characterized by fever, arthritis, rash, hepatosplenomegaly, and macrophage activation syndrome; however, its pathogenesis is still unclear. Elevated serum interleukin (IL)-18 concentrations and decreased natural killer (NK) cell activity are characteristic of active disease; thus, we examined IL-18 signaling in NK cells from sJIA. METHODS: We analyzed mitogen-activated protein kinase (MAPK) p38 and nuclear factor κ light chain enhancer of activated B cells (NFκB) p65 phosphorylation in NK cells after in vitro recombinant IL-18 (rIL-18) stimulation in 31 patients with sJIA. Associations between clinical features, serum IL-18, and phosphorylation intensity were analyzed. Furthermore, we investigated the effects of high IL-18 concentrations on phosphorylation in NK cells. RESULTS: Patients were divided according to their disease activity: systemic features (n = 8), chronic arthritis (n = 7), remission on medication (n = 10), and remission off medication (n = 6). MAPK p38 and NFκB p65 phosphorylation intensity were the highest in healthy controls, followed by remission off medication, remission on medication (vs. control; MAPK p38, P < 0.01; NFκB p65, P < 0.05), chronic arthritis (P < 0.001, P < 0.001), and systemic features (P < 0.001, P < 0.001). The systemic features group showed a complete defect in phosphorylation. Serum IL-18 was the highest in the systemic features group followed by chronic arthritis, remission on medication (P < 0.01), remission off medication (P < 0.01), and healthy controls (P < 0.01). Phosphorylation intensity was negatively correlated with serum IL-18 (MAPK p38, r2  = 0.42; NFκB p65, r2  = 0.54). Furthermore, healthy control NK cells were cultured with rIL-18; impaired phosphorylation was reproduced in vitro. CONCLUSION: Impaired IL-18 signaling in NK cells correlated with disease activity in sJIA. High serum IL-18 exposure induces impaired MAPK and NFκB phosphorylation in NK cells.

    DOI: 10.1002/acr2.11426

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  • Lipschütz ulcer induced by acute Epstein-Barr virus infection in a young girl. Reviewed International journal

    Takuya Miyazawa, Ren Hayashibe, Tomo Nozawa, Kenichi Nishimura, Shuichi Ito

    Pediatrics international : official journal of the Japan Pediatric Society   64 ( 1 )   e15022   2022.1

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    DOI: 10.1111/ped.15022

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  • Tibia stress injury and the imaging appearance of stress fracture in juvenile dermatomyositis: six patients' experiences. Reviewed International journal

    Tomo Nozawa, Audrey Bell-Peter, Andrea S Doria, Jo-Anne Marcuz, Jennifer Stimec, Kristi Whitney, Brian M Feldman

    Pediatric rheumatology online journal   19 ( 1 )   17 - 17   2021.2

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    BACKGROUND: Tibial stress injuries are frequent injuries of the lower extremity and the most common causes of exercise-induced leg pain among athletes and military recruits. They sometimes occur in patients with pathological conditions of bone metabolism such as osteoporosis or rheumatoid arthritis, but there are previously no cases reported in juvenile dermatomyositis (JDM). Here we report 6 JDM patients who presented with shin pain, and the imaging appearance of tibial stress fractures or stress reactions. CASE PRESENTATION: All 6 patients with JDM presented with shin pain or tenderness in the anterior tibia without any evidence of excessive exercise or traumatic episode. They were diagnosed with tibial stress injuries based on a combination of radiographs, three-phase bone scans, and magnetic resonance imaging (MRI), and 5 out of 6 patients had been treated with prednisone and/or methotrexate at onset of tibial stress injuries. In one patient, we could not find any abnormalities in his radiograph, but the subsequent MRI showed tibial stress reaction. In all 6 patients, the tibial stress injuries improved with only rest and/or analgesics. CONCLUSION: We experienced 6 children with JDM who presented with shin pain, and who were diagnosed with tibial stress fractures or stress reactions. Their underlying disease and weakness, treatment with glucocorticoid and methotrexate, or inactivity may have resulted in these tibial injuries, and made these patients more predisposed than other children. In addition to preventing JDM patients from getting osteoporosis, we need to consider stress reactions when children with JDM complain of sudden shin pain.

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  • Clinical practice guidance for juvenile dermatomyositis (JDM) 2018-Update Reviewed

    Ichiro Kobayashi, Shinji Akioka, Norimoto Kobayashi, Naomi Iwata, Shunichiro Takezaki, Haruna Nakaseko, Satoshi Sato, Yutaka Nishida, Tomo Nozawa, Yuichi Yamasaki, Kazuko Yamazaki, Satoru Arai, Ichizo Nishino, Masaaki Mori

    MODERN RHEUMATOLOGY   30 ( 3 )   411 - 423   2020.5

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  • Clinical significance of subcutaneous fat and fascial involvement in juvenile dermatomyositis Reviewed International journal

    Nodoka Sakurai, Ayako Hino-Shishikura, Tomo Nozawa, Hiroyuki Kamide, Asami Ohara, Kenichi Nishimura, Masako Kikuchi, Ryoki Nara, Masaaki Mori, Shuichi Ito

    MODERN RHEUMATOLOGY   29 ( 5 )   808 - 813   2019.9

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    DOI: 10.1080/14397595.2018.1511026

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  • Primary varicella infection in children with systemic juvenile idiopathic arthritis under tocilizumab therapy Reviewed International journal

    Tomo Nozawa, Kenichi Nishimura, Asami Ohara, Ryoki Hara, Shuichi Ito

    MODERN RHEUMATOLOGY   29 ( 3 )   558 - 562   2019.5

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    DOI: 10.1080/14397595.2016.1254314

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  • Clinical practice guidance for juvenile idiopathic arthritis (JIA) 2018 Reviewed International journal

    Nami Okamoto, Shumpei Yokota, Syuji Takei, Yuka Okura, Tomohiro Kubota, Masaki Shimizu, Tomo Nozawa, Naomi Iwata, Hiroaki Umebayashi, Noriko Kinjo, Tomoko Kunishima, Junko Yasumura, Masaaki Mori

    MODERN RHEUMATOLOGY   29 ( 1 )   41 - 59   2019.1

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    DOI: 10.1080/14397595.2018.1514724

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  • Infliximab for the Treatment of Refractory Kawasaki Disease: A Nationwide Survey in Japan Reviewed International journal

    Hiroshi Masuda, Tohru Kobayashi, Akira Hachiya, Yasutaka Nakashima, Hiroyuki Shimizu, Tomo Nozawa, Yoshihito Ogihara, Shuichi Ito, Shinichi Takatsuki, Nobuyuki Katsumata, Yasuo Suzuki, Satoshi Takenaka, Keiichi Hirono, Tomio Kobayashi, Hiroshi Suzuki, Eisuke Suganuma, Kei Takahashi, Tsutomu Saji

    JOURNAL OF PEDIATRICS   195   115 - +   2018.4

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    DOI: 10.1016/j.jpeds.2017.10.013

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  • Severe infusion reactions to tocilizumab in young children with systemic juvenile idiopathic arthritis Reviewed

    Tomo Nozawa, Kenichi Nishimura, Takashi Ohya, Asami Oohara, Ryoki Hara Shuichi Ito

    International Journal of Clinical Rheumatology   13 ( 2 )   2018

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    DOI: 10.4172/1758-4272.1000175

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  • Coronary-Artery Aneurysm in Tocilizumab-Treated Children with Kawasaki's Disease Reviewed International journal

    Tomo Nozawa, Tomoyuki Imagawa, Shuichi Ito

    NEW ENGLAND JOURNAL OF MEDICINE   377 ( 19 )   1894 - 1896   2017.11

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    DOI: 10.1056/NEJMc1709609

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  • Usefulness of two interferon-gamma release assays for rheumatic disease Reviewed International journal

    Tomo Nozawa, Masaaki Mori, Kenichi Nishimura, Nodoka Sakurai, Masako Kikuchi, Ryoki Hara, Shumpei Yokota

    PEDIATRICS INTERNATIONAL   58 ( 5 )   347 - 352   2016.5

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    DOI: 10.1111/ped.12885

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  • Characteristics of FDG-PET findings in the diagnosis of systemic juvenile idiopathic arthritis Reviewed International journal

    Taichi Kanetaka, Masaaki Mori, Ken-ichi Nishimura, Tomo Nozawa, Masako Kikuchi, Nodoka Sakurai, Ryoki Hara, Kazuko Yamazaki, Shumpei Yokota

    MODERN RHEUMATOLOGY   26 ( 3 )   362 - 367   2016

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    DOI: 10.3109/14397595.2015.1082686

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  • Mycophenolate mofetil as maintenance therapy for childhood-onset systemic lupus erythematosus patients with severe lupus nephritis Reviewed International journal

    Toshitaka Kizawa, Tomo Nozawa, Masako Kikuchi, Kiyotaka Nagahama, Koji Okudela, Takako Miyamae, Tomoyuki Imagawa, Tomoko Nakamura, Masaaki Mori, Shumpei Yokota, Hiroyuki Tsutsumi

    MODERN RHEUMATOLOGY   25 ( 2 )   210 - 214   2015.3

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    DOI: 10.3109/14397595.2014.950810

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  • Pathogenesis of systemic inflammatory diseases in childhood: "Lessons from clinical trials of anti-cytokine monoclonal antibodies for Kawasaki disease, systemic onset juvenile idiopathic arthritis, and cryopyrin-associated periodic fever syndrome" Reviewed International journal

    Shumpei Yokota, Masako Kikuchi, Tomo Nozawa, Taichi Kanetaka, Tomomi Sato, Kazuko Yamazaki, Nodoka Sakurai, Ryoki Hara, Masaaki Mori

    MODERN RHEUMATOLOGY   25 ( 1 )   1 - 10   2015.1

  • A national survey on current use of mycophenolate mofetil for childhood-onset systemic lupus erythematosus in Japan Reviewed International journal

    Ryoki Hara, Hirotaka Miyazawa, Kenichi Nishimura, Takahiro Momoi, Tomo Nozawa, Masako Kikuchi, Nodoka Sakurai, Toshitaka Kizawa, Sanae Shimamura, Shinsuke Yasuda, Keiju Hiromura, Ken-ei Sada, Yasushi Kawaguchi, Naoto Tamura, Syuji Takei, Yoshinari Takasaki, Tatsuya Atsumi, Masaaki Mori

    MODERN RHEUMATOLOGY   25 ( 6 )   858 - 864   2015

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    DOI: 10.3109/14397595.2015.1077555

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  • Serum levels of anti-SRP54 antibodies reflect disease activity of necrotizing myopathy in a child treated effectively with combinatorial methylprednisolone pulses and plasma exchanges followed by intravenous cyclophosphamide Reviewed International journal

    Mei Momomura, Takako Miyamae, Tomo Nozawa, Masako Kikuchi, Toshitaka Kizawa, Tomoyuki Imagawa, Laurent Drouot, Fabienne Jouen, Olivier Boyer, Shumpei Yokota

    MODERN RHEUMATOLOGY   24 ( 3 )   529 - 531   2014.5

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    DOI: 10.3109/14397595.2013.852852

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  • [A case of severe systemic juvenile idiopathic arthritis introduced tocilizumab in early phase of the disease]. Reviewed

    Takeshi Ikegawa, Kazuko Yamazaki, Kenichi Nishimura, Taichi Kanetaka, Masako Kikuchi, Tomo Nozawa, Ryouki Hara, Tomomi Sato, Nodoka Sakurai, Shumpei Yokota

    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology   37 ( 3 )   176 - 82   2014

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    A 14-year-old boy was admitted in the former hospital with remittent fever, erythematous rash, joint pain, and muscle pain. Antibiotics were ineffectively administered and then, methylprednisolone (mPSL) pulse therapy with methotrexate was introduced under the diagnosis of suspected systemic juvenile idiopathic arthritis (JIA). However, he still had clinical symptoms and signs, and was transferred to our hospital. Re-examination revealed no malignancies including acute leukemia by bone marrow aspiration, no infectious agents by septic work, and no significant increases of antibodies against several viruses including CMV, EBV, HSV, Parvovirus B19, adenovirus, and so forth. FDG-PET demonstrated the accumulation of (18)F-FDG in bone marrows suggesting systemic JIA. Laboratory findings were leukocytosis and granulocytosis, elevated levels of C-reactive protein, D-dimer, ferritin, and interleukin-6. He was finally diagnosed as having severe systemic JIA. Thus, soon after the additional mPSL pulse therapy, tocilizumab (TCZ) was successfully introduced. In conclusion, for systemic JIA patients with severe systemic inflammation, it will be reasonable to introduce tocilizumab earlier than the guideline suggested to reduce side effects of long-term and large amounts of steroids and to protect the transition to macrophage activation syndrome. Further studies will be needed to recommend appropriate timing of tocilizumab introduction.

    DOI: 10.2177/jsci.37.176

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  • Guidance on the use of canakinumab in patients with cryopyrin-associated periodic syndrome in Japan Reviewed International journal

    Shumpei Yokota, Ryuta Nishikomori, Hidetoshi Takada, Masako Kikuchi, Tomo Nozawa, Taichi Kanetaka, Toshitaka Kizawa, Takako Miyamae, Masaaki Mori, Toshio Heike, Toshiro Hara, Tomoyuki Imagawa

    MODERN RHEUMATOLOGY   23 ( 3 )   425 - 429   2013.5

  • [Chronic recurrent multifocal osteomyelitis with interstitial myositis]. Reviewed

    Saori Nagashima, Tomo Nozawa, Toshitaka Kizawa, Masako Kikuchi, Takako Miyamae, Tomoyuki Imagawa, Hiroshi Inaba, Tatsuharu Sato, Kunio Hashimoto, Noriko Aida, Shumpei Yokota

    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology   36 ( 1 )   52 - 7   2013

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    Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory, non-infectious disorder of skeletal system mainly seen in children. We report a case of CRMO presenting with fever and leg pain. The patient was an 11-year-old boy complaining of a fever, swelling and pain on his right foot, and pain on both legs. Although serum levels of CK and aldolase were not increased, MRI imaging suggested polymyositis. Muscle biopsy showed interstitial infiltration of inflammatory cells without any evidences of dermatomyositis or polymyositis. One month later, he complained of a swelling, pain and redness of his left clavicle as recurrently experienced during the recent 6 months, and MRI investigation indicated the diagnosis of osteomyelitis. Bone biopsy was performed and showed chronic inflammatory changes with negative bacterial culture. Multiple bone lesions and muscle uptake of FDG in his legs were revealed by whole body FDG-PET/CT, and he was diagnosed as having CRMO with interstitial myositis. The combinatorial administration of non-steroidal anti-inflammatory drugs and bisphosphonate successfully improved his clinical symptoms and laboratory abnormalities. To our knowledge, there is no report of a patient of CRMO associated with interstitial myositis.

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  • 2 cases of HLA-B27-positive seronegative spondylarthritides in pediatric age treated with adalimumab. Reviewed

    Tomomi Sato, Tomo Nozawa, Taichi Kanetaka, Masako Kikuchi, Nodoka Sakurai, Kazuko Yamazaki, Takahiro Momoi, Yoshiyuki Namai, Shumpei Yokota

    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology   36 ( 6 )   473 - 7   2013

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    Seronegative spondyloarthritis is strongly correlated to HLA-B27, and in the long term, it causes limitations to the movements of vertebral joints. In recent years, the numbers of patients diagnosed with axial spondyloarthritis have increased due to the widespread use of magnetic resonance imaging (MRI) for diagnostic imaging. We report the cases of 2 pediatric patients diagnosed with axial spondyloarthritis, and whose disease activity was successfully controlled using adalimumab. In case 1, the patient was a 15-year-old boy. The onset of the disease was marked by neck pain ; HLA-B27 was positive, and the MRI revealed sacroiliac arthritis. After being diagnosed with axial spondyloarthritis, he began receiving oral steroid therapy. Gradual recurrence was observed, and adalimumab treatment was initiated. In case 2, the patient was a 9-year-old boy. Bilateral pain was present in the shoulder joints, ankles, and knee joints. The patient was diagnosed with polyarticular juvenile idiopathic arthritis, and treatment using oral steroids, immunosuppressants and tocilizumab. The arthralgia disappeared, but at the age of 12 years, pain recurred in the sacroiliac joint and the Achilles tendon, the HLA-B27 was positive, and the MRI revealed sacroiliac arthritis. The condition was diagnosed as axial spondyloarthritis; adalimumab treatment was initiated. Adalimumab was effective in the treatment of axial spondylitis occurring in childhood.

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  • Analysis of gender differences in genetic risk: association of TNFAIP3 polymorphism with male childhood-onset systemic lupus erythematosus in the Japanese population. Reviewed International journal

    Keisuke Kadota, Masaaki Mori, Masakatsu Yanagimachi, Takako Miyamae, Takuma Hara, Taichi Kanetaka, Tomo Nozawa, Masako Kikuchi, Ryoki Hara, Tomoyuki Imagawa, Tetsuji Kaneko, Shumpei Yokota

    PloS one   8 ( 8 )   e72551   2013

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    DOI: 10.1371/journal.pone.0072551

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  • Efficacy and limitation of infliximab treatment for children with Kawasaki disease intractable to intravenous immunoglobulin therapy: report of an open-label case series. Reviewed International journal

    Masaaki Mori, Tomoyuki Imagawa, Ryoki Hara, Masako Kikuchi, Takuma Hara, Tomo Nozawa, Takako Miyamae, Shumpei Yokota

    The Journal of rheumatology   39 ( 4 )   864 - 7   2012.4

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    DOI: 10.3899/jrheum.110877

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  • [Febrile responses in patients with pediatric rheumatic diseases]. Reviewed

    Shumpei Yokota, Masako Kikuchi, Tomo Nozawa, Toshitaka Kizawa, Taichi Kanetaka, Keisuke Kadota, Takako Miyamae, Masaaki Mori

    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology   35 ( 6 )   511 - 9   2012

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    Fever is one of the critical symptoms of patients in pediatrics field. It indicates inflammatory focus somewhere in the body, and the major causes of fever are infectious diseases. Recent progresses of our knowledge about autoinflammatory syndrome promoted the investigation of the mechanism of fever, and suggested that the pro-inflammatory cytokines are the direct causative agents of fever. The basic science revealed that cooperation of IL-6 and IL-1β induces febrile response. Fever of unknown origin (FUO) remains a challenging problem. Rheumatic diseases, rare infectious diseases, and benign tumors and malignancies are diagnoses to be differentiated. FDG-PET is recently proved a valuable tool for the identification of the etiology in patients with FUO. Since the introduction of biological response modifiers into the treatment of patients with pediatric rheumatic diseases has shifted the therapeutic paradigm, a new concept that the blockade of a unique pro-inflammatory cytokine brings cessation of whole inflammatory responses affected tremendously the clinical medicine. A more investigation of inflammation and its pathophisiology will be needed in pediatric rheumatology.

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  • Neonatal herpes simplex type II virus infection complicated with meningitis and virus-associated hemophagocytic syndrome Reviewed

    Chie Arai, Tomo Nozawa, Takuma Hara, Masako Kikuchi, Mei Momomura, Toshiki Kizawa, Reita Tanoshima, Maiko Kita, Tomoko Yokosuka, Takako Miyamae, Shiho Iwasaki, Tomoyuki Imagawa, Shunpei Yokota

    Japanese Journal of Clinical Immunology   35 ( 1 )   87 - 91   2012

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  • Infliximab for a girl with refractory pyoderma gangrenosum Reviewed

    Tomo Nozawa, Ryoki Hara, Jumpei Kinoshita, Fumie Sano, Takako Miyamae, Tomoyuki Imagawa, Masaaki Mori, Michiko Hirokado, Kazuo Takahashi, Yoshiaki Inayama, Shumpei Yokota

    Japanese Journal of Clinical Immunology   31 ( 6 )   454 - 459   2008

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    DOI: 10.2177/jsci.31.454

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MISC

  • 免疫アレルギー疾患における分子標的薬 抗IL-6受容体抗体(トシリズマブ)

    野澤 智

    日本小児アレルギー学会誌   38 ( 2 )   204 - 210   2024.6

  • 施設入所により回避・制限性食物摂取症が改善した重度知的障害を伴う自閉スペクトラム症の一例

    武石 潤子, 野澤 智, 伊藤 秀一

    横浜医学   75 ( 2 )   59 - 63   2024.6

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  • 小児期発症全身性エリテマトーデスの診療指針~海外の現状~

    野澤智

    日本リウマチ学会総会・学術集会プログラム・抄録集   68th   2024

  • Systemic sclerosis-anti-Scl-70 antibodies, anti-centromere antibodies, anti-RNA polymerase III antibodies

    野澤智

    小児内科   56   2024

  • 経過中に仙腸関節炎,潰瘍性大腸炎を合併した全身型若年性特発性関節炎

    西村謙一, 神山裕二, 大原亜沙実, 服部成良, 野澤智, 伊藤秀一

    日本リウマチ学会総会・学術集会プログラム・抄録集   68th   2024

  • 関節型若年性特発性関節炎に対するTNF阻害薬の継続率と無効例に関する検討

    服部成良, 神山裕二, 大原亜沙実, 西村謙一, 野澤智, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   32nd   2023

  • 当院でベリムマブを導入した小児期発症全身性エリテマトーデス患者5例の検討

    大原亜沙実, 神山裕二, 服部成良, 西村謙一, 野澤智, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   32nd   2023

  • IgG4関連疾患を疑う硬化性腸間膜炎の小児例

    中田紘乃, 西村謙一, 村岡枝里香, 村岡枝里香, 神山裕二, 大原亜沙実, 服部成良, 野澤智, 山中正二, 藤井誠志, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   32nd   2023

  • リツキシマブ投与が有効であった全身性強皮症の小児例

    神山裕二, 村瀬絢子, 大原亜沙実, 服部成良, 西村謙一, 野澤智, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   32nd   2023

  • 無痛性に多関節破壊を来した血清反応陰性関節炎の15歳男児例

    梶田由衣, 神山裕二, 服部成良, 西村謙一, 野澤智, 伊藤秀一

    東日本小児リウマチ研究会プログラム・抄録集(Web)   12th   2023

  • トシリズマブとミコフェノール酸モフェチルの併用でステロイドの減量ができた乳児期発症高安動脈炎の一例

    西田豊, 山田諭, 井上貴晴, 佐藤幸一郎, 八木久子, 野澤智, 渡部登志雄, 荒川浩一, 滝沢琢己

    アレルギー   72 ( 1 )   2023

  • 当科のリウマチ外来における移行期支援プログラムの実践報告

    西村謙一, 村瀬絢子, 神山裕二, 氏家圭子, 齋藤裕美, 大原亜沙実, 服部成良, 野澤智, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   32nd   2023

  • 若年性特発性関節炎におけるJAK阻害薬の最近の知見 トファシチニブを中心に

    野澤 智

    リウマチ科   68 ( 5 )   581 - 588   2022.11

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  • 脳結核腫の合併が疑われた結核性胸腹膜炎のDown症候群の一例

    服部 成良, 神山 裕二, 村瀬 絢子, 西村 謙一, 野澤 智, 伊藤 秀一

    日本小児感染症学会総会・学術集会プログラム・抄録集   54回   279 - 279   2022.11

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  • 肺膿瘍との鑑別を要し,診断・治療に難渋した多発血管炎性肉芽腫症の再燃例

    神山 裕二, 林邉 廉, 村瀬 絢子, 服部 成良, 西村 謙一, 野澤 智, 伊藤 秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   31回   167 - 167   2022.10

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  • 小児期COVID-19関連多系統炎症性症候群3例の臨床的特徴

    服部 成良, 神山 裕二, 村瀬 絢子, 西村 謙一, 野澤 智, 伊藤 秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   31回   158 - 158   2022.10

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  • 若年性皮膚筋炎(JDM)の1男児例

    齋藤 衣子, 藤岡 かおる, 溝呂木 園子, 野澤 智, 神山 裕二, 東田 耕輔

    日本小児科学会雑誌   126 ( 4 )   735 - 735   2022.4

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  • 整形外科医のための小児リウマチ移行期医療の実際と課題 小児リウマチ移行期医療の実際と症例提示

    崔 賢民, 手塚 太郎, 秋山 豪介, 熊谷 研, 服部 成良, 西村 謙一, 野澤 智, 伊藤 秀一, 持田 勇一, 稲葉 裕

    日本整形外科学会雑誌   96 ( 2 )   S416 - S416   2022.3

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  • 膠原病妊娠登録調査小委員会企画:PLEASURE-Jを大きく育てていくために 学会主導の若年性診断早期疾患レジストリを用いた、患者・主治医主体のエビデンス構築の可能性

    金子 佳代子, 阿部 靖矢, 岩井 秀之, 岩田 恭宜, 宇都宮 雅子, 磯島 咲子, 落合 萌子, 島田 裕美, 白井 剛志, 土田 優美, 中山田 真吾, 花岡 洋成, 野澤 智, 渡邉 あかね, 三浦 瑶子, 宮川 英子, 森山 繭子, 奥 健志, 金子 祐子, 田中 良哉, 藤尾 圭志, 松下 雅和, 宮前 多佳子, 矢嶋 宣幸, 和田 隆志, 村島 温子, 中島 亜矢子

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   242 - 242   2022.3

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  • 小児の膠原病および若年性特発性関節炎 我が国の若年全身性エリテマトーデス患者の現状と妊娠転帰を含む長期・短期予後に関する前向きコホート研究【日本リウマチ学会ワーキンググループ】低疾患活動性(LLDAS)に与える影響因子の検討

    野澤 智, 宮前 多佳子, 金子 佳代子, 阿部 靖矢, 磯島 咲子, 岩井 秀之, 岩田 恭宜, 宇都宮 雅子, 大西 香絵, 落合 萌子, 島田 裕美, 白井 剛志, 土田 優美, 中山田 真吾, 花岡 洋成, 三浦 瑶子, 森山 繭子, 渡邉 あかね, 奥 健志, 金子 祐子, 田中 良哉, 藤尾 圭志, 松下 雅和, 矢嶋 宣幸, 和田 隆志, 中島 亜矢子, 村島 温子

    日本リウマチ学会総会・学術集会プログラム・抄録集   66回   455 - 455   2022.3

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  • ステロイド薬による合併症を呈した乳児期発症高安動脈炎にトシリズマブとミコフェノール酸モフェチルが有効であった一例

    西田 豊, 山田 諭, 井上 貴晴, 佐藤 幸一郎, 八木 久子, 野澤 智, 渡部 登志雄, 荒川 浩一, 滝沢 琢己

    日本小児科学会雑誌   126 ( 2 )   283 - 283   2022.2

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  • 自己免疫性溶血性貧血,血小板減少を合併したランゲルハンス細胞組織球症の早期乳児例

    吉川 奈央子, 西村 謙一, 神山 裕二, 大砂 光正, 林邉 廉, 村瀬 絢子, 服部 成良, 江中 牧子, 辻本 信一, 竹内 正宜, 野澤 智, 柴 徳生, 伊藤 秀一

    日本小児科学会雑誌   126 ( 2 )   331 - 331   2022.2

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  • 小児期発症ベーチェット病における治療抵抗例の検討

    服部 成良, 神山 裕二, 林邉 廉, 村瀬 絢子, 西村 謙一, 野澤 智, 伊藤 秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   30回   165 - 165   2021.10

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  • 若年性特発性関節炎患者の骨密度に関する実態調査

    神山 裕二, 林邉 廉, 村瀬 絢子, 服部 成良, 西村 謙一, 野澤 智, 伊藤 秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   30回   171 - 171   2021.10

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  • 寛解達成後にカナキヌマブを減量された全身型若年性特発性関節炎患者の実態

    西村 謙一, 神山 裕二, 林邉 廉, 村瀬 絢子, 服部 成良, 野澤 智, 伊藤 秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   30回   169 - 169   2021.10

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  • 全身型若年性特発性関節炎の長期経過における、systemic Juvenile Arthritis Disease Activity Score(sJADAS)の検討

    林邉 廉, 神山 裕二, 服部 成良, 村瀬 絢子, 西村 謙一, 野澤 智, 伊藤 秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   30回   170 - 170   2021.10

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  • Medication Withdrawal in JIA

    赤峰 敬治, 江波戸 孝輔, 野澤 智

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   30回   88 - 88   2021.10

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  • デノスマブ投与間隔延長による高Ca血症の一例

    林邉 廉, 服部 成良, 西村 謙一, 野澤 智, 伊藤 秀一

    日本リウマチ学会総会・学術集会プログラム・抄録集   65回   609 - 609   2021.3

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  • 小児期および成人移行期小児リウマチ患者の全国調査データの解析と両者の異同性に基づいた全国的「シームレス」診療ネットワーク構築による標準的治療の均てん化 小児期シェーグレン症候群の移行期医療に向けた支援ガイドブック作成と小児-成人レジストリの確立

    井上祐三朗, 岩田直美, 小林一郎, 楢崎秀彦, 西山進, 野澤智, 野中由希子, 冨板美奈子

    小児期および成人移行期小児リウマチ患者の全国調査データの解析と両者の異同性に基づいた全国的「シームレス」診療ネットワーク構築による標準的治療の均てん化 令和元年度 研究報告書(Web)   2020

  • FDG-PET/CTを契機に診断された、後腹膜リンパ節に生じた炎症性偽腫瘍の小児例 Reviewed

    横田 望美, 西村 謙一, 宇高 直子, 玉那覇 瑛太, 大原 亜沙実, 野澤 智, 原 良紀, 伊藤 秀一

    小児科臨床   72 ( 9 )   1465 - 1469   2019.9

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  • 小児期および成人移行期小児リウマチ患者の全国調査データの解析と両者の異同性に基づいた全国的「シームレス」診療ネットワーク構築による標準的治療の均てん化 小児期シェーグレン症候群の移行期医療に向けた支援ガイドブック作成と小児-成人レジストリの確立

    井上祐三朗, 岩田直美, 小林一郎, 楢崎秀彦, 西山進, 野澤智, 野中由希子, 冨板美奈子

    小児期および成人移行期小児リウマチ患者の全国調査データの解析と両者の異同性に基づいた全国的「シームレス」診療ネットワーク構築による標準的治療の均てん化 平成30年度 研究報告書(Web)   2019

  • 【知っておくべき治療可能な胎児・新生児希少疾患】(自己)免疫疾患 クリオピリン関連周期性発熱症候群(新生児期発症多臓器系炎症性疾患)

    野澤 智, 伊藤 秀一

    周産期医学   48 ( 10 )   1380 - 1384   2018.10

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  • 【新薬が変える子ども医療-薬物の使い分けと作用機序】新しく開発された薬 膠原病・自己炎症性疾患など 家族性地中海熱・高IgD症候群・新生児期発症多臓器系炎症性疾患など カナキヌマブ

    野澤 智

    小児内科   50 ( 10 )   1657 - 1660   2018.10

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  • 【日常診療にひそむ小児リウマチ性疾患】小児リウマチ性疾患の診断と治療 全身型若年性特発性関節炎と不明熱

    野澤 智

    小児科診療   81 ( 6 )   771 - 776   2018.6

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  • 小児期シェーグレン症候群患者の移行支援にむけたガイドの作成

    井上祐三朗, 井上祐三朗, 岩田直美, 小林一郎, 楢崎秀彦, 西山進, 野澤智, 野中由希子, 冨板美奈子, 森雅亮

    日本小児リウマチ学会総会・学術集会プログラム・抄録集   28th   2018

  • 小児期シェーグレン症候群の移行期医療に向けた支援ガイドブック作成と小児-成人レジストリの確立

    井上祐三朗, 岩田直美, 小林一郎, 楢崎秀彦, 西山進, 野澤智, 野中由希子, 冨板美奈子

    小児期および成人移行期小児リウマチ患者の全国調査データの解析と両者の異同性に基づいた全国的「シームレス」診療ネットワーク構築による標準的治療の均てん化 平成29年度 研究報告書(Web)   2018

  • 小児有熱性尿路感染症の起炎菌による臨床像の違い 大腸菌と腸球菌との比較

    大嶋 明, 福山 綾子, 小林 慈典, 鏑木 陽一, 西村 謙一, 野澤 智, 伊藤 秀一

    日本小児腎不全学会雑誌   37   206 - 210   2017.7

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  • 自己炎症症候群 周期性発熱症候群患者を対象としたカナキヌマブのランダム化プラセボ対照二重盲検多施設国際共同第III相臨床試験における日本人TNF受容体関連周期性症候群患者での評価

    野澤 智, 西小森 隆太, 金子 詩子, De Benedetti Fabrizio, Speziale Antonio, Junge Guido, 原 良紀

    日本リウマチ学会総会・学術集会プログラム・抄録集   61回   449 - 449   2017.3

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  • 小児リウマチ性疾患の最新治療 II.若年性特発性関節炎 難治性関節型JIAの治療:生物学的製剤を中心に

    NOZAWA TOMO

    小児科診療   78 ( 8 )   1075 - 1080   2015.8

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  • 若年性線維筋痛症(JFM)

    横田 俊平, 菊地 雅子, 野澤 智, 金高 太一, 園田 香織, 宮前 多佳子

    小児科   55 ( 13 )   1959 - 1967   2014.12

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  • 若年性線維筋痛症患児の入院治療の実際と効果

    菊地 雅子, 野澤 智, 佐藤 知美, 西村 謙一, 金高 太一, 櫻井 のどか, 原 良紀, 山崎 和子, 横田 俊平

    小児リウマチ   5 ( 1 )   26 - 31   2014.6

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  • A case of severe systemic juvenile idiopathic arthritis introduced tocilizumab in early phase of the disease

    Takeshi Ikegawa, Kazuko Yamazaki, Kenichi Nishimura, Taichi Kanetaka, Masako Kikuchi, Tomo Nozawa, Ryouki Hara, Tomomi Sato, Nodoka Sakurai, Shumpei Yokota

    Japanese Journal of Clinical Immunology   37 ( 3 )   176 - 182   2014.6

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  • 悪性疾患、リンパ節結核との鑑別を要した左腋窩BCGリンパ節炎の1例

    原 拓麿, 今川 智之, 野澤 智, 菊地 雅子, 木澤 敏毅, 宮前 多佳子, 森 雅亮, 横田 俊平, 山中 正二

    小児科臨床   67 ( 2 )   231 - 236   2014.2

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  • Three Children of Inflammatory Myopathy of the Muscle Bundle Interstitium Associated with Systemic Inflammatory Diseases

    KIKUCHI MASAKO, NAGASHIMA SAORI, NOZAWA SATOSHI, KANETAKA TAICHI, KIZAWA TOSHITAKE, MIYAMAE TAEKO, IMAGAWA TOMOYUKI, MORI MASAAKI, YOKOTA SHUMPEI

    日本小児科学会雑誌   118 ( 1 )   23 - 29   2014.1

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  • 2 cases of HLA-B27-positive seronegative spondylarthritides in pediatric age treated with adalimumab

    Tomomi Sato, Tomo Nozawa, Taichi Kanetaka, Masako Kikuchi, Nadooka Sakurai, Kazuko Yamazaki, Takahiro Momoi, Yoshiyuki Namai, Shumpei Yokota

    Japanese Journal of Clinical Immunology   36 ( 6 )   473 - 477   2013.12

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  • Efficacy of mobilized operation for knee joint contracture of a patient with oligo-articular juvenile idiopathic arthritis.

    SATO TOMOMI, NOZAWA TOMO, KANETAKA TAICHI, KIKUCHI MASAKO, YAMAZAKI KAZUKO, IMAGAWA TOMOYUKI, ATA YURIKA, INABA YUTAKA, SAITO TOMOYUKI, MIZUOCHI KAZUYA, YOKOTA SHUMPEI

    小児リウマチ   4 ( 1 )   46 - 49   2013.6

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  • 小児リウマチ性疾患の診断と治療Update 4.若年性皮膚筋炎

    NOZAWA TOMO, YOKOTA SHUMPEI

    小児科臨床   66 ( 5 )   865 - 872   2013.5

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  • 小児リウマチ性疾患の診断と治療Update 1.小児リウマチ性疾患の診かた・考え方

    YOKOTA SHUMPEI, KIKUCHI MASAKO, NOZAWA TOMO, KANETAKA TAICHI, YAMAZAKI KAZUKO, SATO TOMOMI, MORI MASAAKI

    小児科臨床   66 ( 5 )   843 - 849   2013.5

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  • Chronic recurrent multifocal osteomyelitis with interstitial myositis

    Saori Nagashima, Tomo Nozawa, Toshitaka Kizawa, Masako Kikuchi, Takako Miyamae, Tomoyuki Imagawa, Hiroshi Inaba, Tatsuharu Sato, Kunio Hashimoto, Noriko Aida, Shumpei Yokota

    Japanese Journal of Clinical Immunology   36 ( 1 )   52 - 57   2013.2

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  • Febrile responses in patients with pediatric rheumatic diseases

    Shumpei Yokota, Masako Kikuchi, Tomo Nozawa, Toshitaka Kizawa, Taichi Kanetaka, Keisuke Kadota, Takako Miyamae, Masaaki Mori

    Japanese Journal of Clinical Immunology   35 ( 6 )   511 - 519   2012.12

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  • 炎症性サイトカインからみた炎症病態の考え方と治療法の最近の動向~川崎病,全身型若年性特発性関節炎,クリオピリン関連周期性発熱症候群に対するサイトカイン遮断療法の効果について~

    YOKOTA SHUMPEI, KIKUCHI MASAKO, NOZAWA SATOSHI, KAISA KAORI, KANETAKA TAICHI, SONODA KAORI, TAKAHASHI MAYU, FUJII KENTARO, YAMASAKI KAZUKO, MORI MASAAKI, HARA TAKUMA, HARA YOSHINORI, IMAGAWA TOMOYUKI, MIYAMAE TAEKO

    日本小児科学会雑誌   116 ( 12 )   1829 - 1841   2012.12

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  • クリオピリン関連周期性発熱症候群に対する生物学的製剤治療の手引き(2012)カナキヌマブ

    YOKOTA SHUMPEI, NISHIKOMORI RYUTA, TAKADA HIDETOSHI, KIKUCHI MASAKO, NOZAWA SATOSHI, KANETAKA TAICHI, KIZAWA TOSHITAKE, MIYAMAE TAEKO, MORI MASAAKI, HEIKE TOSHIO, HARA TOSHIRO, IMAGAWA TOMOYUKI

    日本小児科学会雑誌   116 ( 9 )   1337 - 1341   2012.9

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  • 若年性皮膚筋炎の皮膚所見

    NOZAWA TOMO, TAKAHASHI KAZUO, YOKOTA SHUMPEI

    日本小児皮膚科学会雑誌   31 ( 2 )   93,3 - 97,3   2012.6

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  • TNF阻害薬が無効でIL-6阻害薬(トシリズマブ)に変更し改善をみた難治性多関節型若年性特発性関節炎の2例

    木澤 敏毅, 野澤 智, 原 拓麿, 菊地 雅子, 百村 芽衣, 宮前 多佳子, 今川 智之, 横田 俊平, 森 雅亮, 堤 裕幸

    臨床リウマチ   24 ( 2 )   146 - 151   2012.6

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  • A case of systemic juvenile idiopathic arthritis complicated with drug-induced liver dysfunction.

    KIZAWA TOSHITAKA, NAGASHIMA SAORI, NOZAWA TOMO, KIKUCHI MASAKO, MIYAMAE TAKAKO, IMAGAWA TOMOYUKI, YOKOTA SHUMPEI, NAKAJIMA SHOKO, SOGO TSUYOSHI, INUI AYANO, TSUTSUMI HIROYUKI

    臨床リウマチ   24 ( 2 )   139 - 145   2012.6

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  • マクロファージ活性化症候群の診断と治療

    横田 俊平, 菊地 雅子, 野澤 智, 木澤 敏毅, 金高 太一, 宮前 多佳子, 今川 智之

    リウマチ科   47 ( 3 )   300 - 305   2012.3

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  • An Approach to the Patients with Cryopyrin-associated Periodic Syndrome (CAPS): A New Biologic Response Modifier, Canakinumab

    Shumpei Yokota, Masako Kikuchi, Tomo Nozawa, Toshiatsu Kizawa, Taichi Kanetaka, Takako Miyamae, Masa Aki Mori, Ryohta Nishikomori, Hidetoshi Takata, Toshio Heike, Toshiro Hara, Tomoyuki Imagawa

    Japanese Journal of Clinical Immunology   35 ( 1 )   23 - 29   2012.2

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  • Neonatal herpes simplex type II virus infection complicated with meningitis and virus-associated hemophagocytic syndrome

    ARAI CHIE, NOZAWA TOMO, HARA TAKUMA, KIKUCHI MASAKO, MOMOMURA MEI, KIZAWA TOSHIKI, TANOSHIMA REITA, KITA MAIKO, YOKOSUKA TOMOKO, MIYAMAE TAKAKO, IWASAKI SHIHO, IMAGAWA TOMOYUKI, YOKOTA SHUMPEI

    日本臨床免疫学会会誌   35 ( 1 )   87 - 91   2012.2

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  • 小児の遷延性咳嗽に対する横浜医療センター小児科での評価と治療

    野澤 智

    化学療法の領域   26 ( 4 )   648 - 650   2010.3

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  • インフリキシマブが奏効した壊疽性膿皮症の1例

    野澤 智, 原 良紀, 木下 順平, 佐野 史絵, 宮前 多佳子, 今川 智之, 森 雅亮, 廣門 未知子, 高橋 一夫, 稲山 嘉明, 横田 俊平

    日本臨床免疫学会会誌   31 ( 6 )   454 - 459   2008.12

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Presentations

  • 27-year-old ADA2 deficiency with skin symptoms from 1 year old

    西村謙一, 林邉廉, 服部成良, 大宅喬, 野澤智, 伊藤秀一

    日本免疫不全・自己炎症学会総会・学術集会プログラム・抄録集  2021 

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    Event date: 2021

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  • デノスマブ投与間隔延長による高Ca血症の一例

    林邉廉, 服部成良, 西村謙一, 野澤智, 伊藤秀一

    日本リウマチ学会総会・学術集会プログラム・抄録集  2021 

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  • 27歳時に確定診断に至ったADA2欠損症患者における単球の機能解析

    西村謙一, 林邉廉, 服部成良, 野澤智, 伊藤秀一

    日本リウマチ学会総会・学術集会プログラム・抄録集  2021 

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  • 我が国の若年全身性エリテマトーデス患者の現状と妊娠転帰を含む長期・短期予後に関する前向きコホート研究【日本リウマチ学会ワーキンググループ】:妊娠例についての報告

    金子佳代子, 阿部靖矢, 磯島咲子, 岩井秀之, 岩田恭宜, 宇都宮雅子, 大西香絵, 落合萌子, 島田裕美, 白井剛志, 土田優美, 中山田真吾, 仁科直, 根本卓也, 野澤智, 平野亨, 三浦瑶子, 森山繭子, 奥健志, 竹内勤, 田中良哉, 藤尾圭志, 松下雅和, 宮前多佳子, 矢嶋宣幸, 和田隆志, 村島温子

    日本リウマチ学会総会・学術集会プログラム・抄録集  2021 

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  • 経皮的腎動脈形成術を行った,腎血管性高血圧を伴う小児期発症高安動脈炎の一例

    林邉廉, 神山裕二, 服部成良, 西村謙一, 野澤智, 伊藤秀一

    東日本小児リウマチ研究会プログラム・抄録集(Web)  2021 

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  • 我が国の若年全身性エリテマトーデス患者の現状と妊娠転帰を含む長期・短期予後に関する前向きコホート研究【日本リウマチ学会ワーキンググループ】:小児発症例と成人発症例の臨床的特徴の比較

    野澤智, 宮前多佳子, 金子佳代子, 阿部靖矢, 磯島咲子, 岩井秀之, 岩田恭宜, 宇都宮雅子, 大西香絵, 落合萌子, 島田裕美, 白井剛志, 土田優美, 中山田真吾, 仁科直, 根本卓也, 平野亨, 三浦瑶子, 森山繭子, 奥健志, 竹内勤, 田中良哉, 藤尾圭志, 松下雅和, 矢嶋宣幸, 和田隆志, 村島温子

    日本リウマチ学会総会・学術集会プログラム・抄録集  2021 

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  • 色素失調症の経過中に,ベーチェット病を発症した一例

    辻真理奈, 豊福悦史, 野澤智, 鹿間芳明, 赤平百恵, 黒澤健司, 佐藤愛, 馬場直子, 今川智之

    日本免疫不全・自己炎症学会総会・学術集会プログラム・抄録集  2018 

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  • 若年性皮膚筋炎診療の手引きの解説 2:治療

    小林一郎, 山崎雄一, 中瀬古春奈, 岩田直美, 佐藤智, 野澤智, 竹崎俊一郎, 小林法元, 山崎和子, 秋岡親司, 森雅亮

    日本リウマチ学会総会・学術集会プログラム・抄録集  2018 

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  • 当院における付着部炎関連関節炎の臨床的検討

    服部成良, 大原亜沙実, 西村謙一, 野澤智, 原良紀, 伊藤秀一

    日本リウマチ学会総会・学術集会プログラム・抄録集  2018 

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  • 若年性皮膚筋炎における皮下脂肪と筋膜の評価

    櫻井のどか, 櫻井のどか, 日野彩子, 野澤智, 上出浩之, 大原亜沙実, 西村謙一, 菊地雅子, 原良紀, 森雅亮, 伊藤秀一

    日本リウマチ学会総会・学術集会プログラム・抄録集  2018 

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  • 若年性皮膚筋炎診療の手引きの解説 1:診断

    小林法元, 小林一郎, 小林一郎, 岩田直美, 佐藤智, 竹崎俊一郎, 中瀬古春奈, 野澤智, 山崎和子, 山崎雄一, 秋岡親司, 森雅亮

    日本リウマチ学会総会・学術集会プログラム・抄録集  2018 

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  • 小児期発症高安動脈炎24名の臨床的解析

    西村謙一, 大原亜沙実, 服部成良, 野澤智, 原良紀, 伊藤秀一, 伊藤秀一

    日本リウマチ学会総会・学術集会プログラム・抄録集  2018 

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  • 若年性全身性エリテマトーデスへのシクロホスファミド静注療法の投与時期と予後の検討

    土田哲也, 土田哲也, 大原亜沙実, 服部成良, 西村謙一, 野澤智, 原良紀, 伊藤秀一

    日本リウマチ学会総会・学術集会プログラム・抄録集  2018 

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  • 全身型若年性特発性関節炎患者におけるNK細胞のIL-18シグナル障害についての研究

    大宅喬, 大西愛, 村瀬絢子, 服部成良, 西村謙一, 野澤智, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2018 

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  • O-157大腸炎で特異的所見を呈したダウン症の1例

    辻真理奈, 飯田貴也, 豊福悦史, 野澤智, 鹿間芳明, 今川智之

    神奈川医学会雑誌  2018 

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  • FDG-PETを用いた全身型若年性特発性関節炎の疾患活動性および予後予測の評価に関する検討

    日野彩子, 西村謙一, 大原亜沙実, 野澤智, 原良紀, 伊藤秀一

    日本リウマチ学会総会・学術集会プログラム・抄録集  2018 

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  • 小児期シェーグレン症候群患者に対する移行支援ガイドの作成

    井上祐三朗, 岩田直美, 小林一郎, 楢崎秀彦, 西山進, 野澤智, 野中由希子, 冨板美奈子, 森雅亮

    日本シェーグレン症候群学会学術集会プログラム・抄録集  2018 

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  • 8染色体トリソミーモザイク症候群経過中にベーチェット病様症状(BD)を呈した2例

    辻真理奈, 豊福悦史, 野澤智, 鹿間芳明, 赤平百絵, 黒澤健司, 今川智之

    日本小児科学会雑誌  2018 

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  • 周期性発熱症候群におけるカナキヌマブの適正使用

    野澤 智

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2017.10  (一社)日本小児リウマチ学会

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    Language:Japanese  

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  • 自己炎症症候群 周期性発熱症候群患者を対象としたカナキヌマブのランダム化プラセボ対照二重盲検多施設国際共同第III相臨床試験における日本人TNF受容体関連周期性症候群患者での評価

    野澤 智, 西小森 隆太, 金子 詩子, De Benedetti Fabrizio, Speziale Antonio, Junge Guido, 原 良紀

    日本リウマチ学会総会・学術集会プログラム・抄録集  2017.3  (一社)日本リウマチ学会

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  • Multi-target therapyが有効であった治療抵抗性全身性強皮症の2症例

    大原亜沙実, 小椋雅夫, 服部成良, 西村謙一, 野澤智, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2017 

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  • 当科における小児期発症高安動脈炎17例の臨床的解析

    西村謙一, 大原亜沙実, 服部成良, 野澤智, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2017 

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  • インフリキシマブを単回投与した川崎病患者におけるツベルクリン反応の意義

    伊奈真一郎, 伊奈真一郎, 西村謙一, 清水博之, 大原亜沙実, 原良紀, 野澤智, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2017 

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  • ホスファチジルセリン依存性抗プロトロンビン抗体陽性であった結節性多発動脈炎の一小児例

    玉那覇瑛太, 玉那覇瑛太, 大原亜沙実, 西村謙一, 野澤智, 原良紀, 江中牧子, 山中正二, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2017 

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  • PET/CTを契機に診断された,後腹膜リンパ節に生じた炎症性偽腫瘍の小児例

    横田望美, 西村謙一, 玉那覇瑛太, 大原亜沙実, 野澤智, 原良紀, 伊藤秀一

    神奈川医学会雑誌  2017 

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  • 川崎病と診断された全身型若年性特発性関節炎患者の特徴と群馬スコア

    西村謙一, 大原亜沙実, 服部成良, 野澤智, 原良紀, 鉾碕竜範, 伊藤秀一

    日本川崎病学会学術集会抄録集  2017 

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  • 難治性IgA血管炎に対する免疫グロブリン療法の有効性と安全性の検討

    西村謙一, 大原亜沙実, 野澤智, 原良紀, 伊藤秀一

    日本小児科学会雑誌  2017 

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  • 小児不明熱患者におけるFDG-PET/CTの意義

    西村謙一, 大原亜沙実, 野澤智, 原良紀, 伊藤秀一

    日本小児放射線学会雑誌(Web)  2017 

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  • 抗MDA5抗体陽性の若年性皮膚筋炎における臨床像,検査所見,治療の解析

    大原亜沙実, 服部成良, 西村謙一, 野澤智, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2017 

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  • 心筋炎を合併した全身型若年性特発性関節炎4例の検討

    服部成良, 大原亜沙実, 西村謙一, 野澤智, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2017 

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  • 発作性寒冷ヘモグロビン尿症に血球貪食性リンパ組織球症を合併した1女児例

    大嶋明, 西村謙一, 伊奈真一郎, 大原亜沙実, 服部成良, 野澤智, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2017 

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  • トシリズマブ使用中に肺炎を合併し,治癒後に空洞性病変が残存した小児リウマチ疾患の2例

    村瀬絢子, 西村謙一, 大原亜沙実, 服部成良, 野澤智, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2017 

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  • 関節症状が持続する難治性全身型若年性特発性関節炎へのトシリズマブとアバタセプト併用療法の試み

    大原亜沙実, 服部成良, 西村謙一, 野澤智, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2017 

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  • γグロブリン療法不応川崎病患者におけるツベルクリン反応

    伊奈真一郎, 伊奈真一郎, 西村謙一, 清水博之, 大原亜沙実, 服部成良, 野澤智, 原良紀, 鉾碕竜範, 伊藤秀一

    日本川崎病学会学術集会抄録集  2017 

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  • 若年性皮膚筋炎の初期治療と長期予後の後方視的検討

    野澤 智, 大原 亜沙実, 西村 謙一, 原 良紀, 伊藤 秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2016.10  (一社)日本小児リウマチ学会

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    Language:Japanese  

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  • 関節型若年性特発性関節炎に対する生物学的製剤自己注射導入の現状と課題に関する検討

    原良紀, 大原亜沙実, 西村謙一, 野澤智, 今川智之, 今川智之, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2016 

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  • 免疫グロブリン静注療法不応の川崎病として紹介された,川崎病後のStevens-Johnson症候群の2例

    西村謙一, 大原亜沙実, 野澤智, 原良紀, 鉾碕竜範, 伊藤秀一

    日本川崎病学会学術集会抄録集  2016 

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  • 血漿交換,Infliximab導入後の冠動脈瘤発生率と長期経過

    鉾碕竜範, 中野裕介, 渡辺重朗, 大原亜沙実, 西村謙一, 野澤智, 原良紀, 伊藤秀一

    日本川崎病学会学術集会抄録集  2016 

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  • マイコプラズマ感染症に急性汎発性膿疱性発疹症を合併した12歳男児の1例

    清田耕助, 西村謙一, 大原亜沙実, 野澤智, 原良紀, 伊藤秀一

    神奈川医学会雑誌  2016 

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  • 小児有熱性尿路感染症の起炎菌による臨床像の違い:大腸菌 vs 腸球菌

    大嶋明, 大嶋明, 西村謙一, 野澤智, 伊藤秀一, 福山綾子, 小林慈典, 鏑木陽一

    日本小児腎不全学会学術集会プログラム・抄録集  2016 

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  • 腹腔内にのみリンパ節腫脹を認めた菊池病の一例

    太田貴子, 西村謙一, 大原亜沙実, 野澤智, 原良紀, 伊藤秀一

    日本小児科学会雑誌  2016 

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  • ガンマグロブリン療法不応川崎病で紹介された患者の川崎病以外の原因

    西村謙一, 大原亜沙実, 野澤智, 原良紀, 伊藤秀一

    日本小児科学会雑誌  2016 

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  • 小児期発症全身性エリテマトーデスにおけるシクロフォスファミド静注療法の導入時期と予後の検討

    土田哲也, 西村謙一, 大原亜沙実, 野澤智, 原良紀, 稲葉彩, 町田裕之, 伊藤秀一, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2016 

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  • アダリムマブを導入した難治性再発性多発軟骨炎の1男児例

    大嶋明, 大原亜沙実, 西村謙一, 野澤智, 原良紀, 伊藤秀一, 江中牧子

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2016 

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  • 抗ラブフィリン3A抗体による中枢性尿崩症を合併した全身性エリテマトーデスの一例

    大原亜沙実, 西村謙一, 野澤智, 菊地雅子, 原良紀, 田島一樹, 寺内康夫, 岩間信太郎, 椙村益久, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2016 

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  • 全身性エリテマトーデスを併発したNRAS関連自己免疫性リンパ増殖症の一女児例

    大原亜沙実, 西村謙一, 野澤智, 菊地雅子, 原良紀, 三宅暁夫, 大橋健一, 高木正稔, 金兼弘和, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2016 

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  • 全身型若年性特発性関節炎患者におけるトシリズマブの反応性予測

    西村謙一, 大原亜沙実, 野澤智, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2016 

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  • 難治性のIgA血管炎に合併したヘパリン起因性血小板減少症(HIT)の小児例

    杉山弘樹, 西村謙一, 大原亜沙実, 野澤智, 原良紀, 伊藤秀一

    神奈川医学会雑誌  2016 

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  • インフリキシマブを含む治療戦略の導入により,川崎病の冠動脈病変発症率は変わったか?

    村瀬絢子, 大原亜沙実, 西村謙一, 野澤智, 原良紀, 鉾碕竜範, 伊藤秀一

    日本川崎病学会学術集会抄録集  2016 

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  • トシリズマブ投与中に初回水痘感染をきたした全身型若年性特発性関節炎6症例の臨床的特徴及び経過のまとめ

    野澤 智, 大原 亜沙実, 西村 謙一, 原 良紀, 伊藤 秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2015.10  (一社)日本小児リウマチ学会

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  • 全身型若年性特発性関節炎における抗トシリズマブ抗体陽性および疑い症例の検討

    野澤 智, 大原 亜沙実, 西村 謙一, 原 良紀, 伊藤 秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2015.10  (一社)日本小児リウマチ学会

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  • 急性期川崎病における胸部CT所見の検討

    西村謙一, 桃井貴裕, 櫻井のどか, 野澤智, 菊地雅子, 原良紀

    日本小児科学会雑誌  2015 

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  • 関節炎が先行した潰瘍性大腸炎の1例

    小倉瑛里子, 西村謙一, 菊地雅子, 櫻井のどか, 野澤智, 原良紀

    日本小児科学会雑誌  2015 

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  • 小児期SLEにおけるミコフェノール酸モフェチルの有用性~本邦使用実態調査成績からの解析~

    森雅亮, 原良紀, 西村謙一, 野澤智, 菊地雅子, 保田晋助, 渥美達也, 嶋村抄苗, 廣村桂樹, 佐田憲映, 武井修治, 川口鎮司, 田村直人, 高崎芳成

    日本リウマチ学会総会・学術集会プログラム・抄録集  2015 

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  • 潰瘍性大腸炎治療中に掌蹠膿疱症と高安動脈炎を併発した14歳女児例

    宮沢啓貴, 櫻井のどか, 桃井貴裕, 西村謙一, 野澤智, 菊地雅子, 原良紀, 角田知之, 十河剛

    日本小児科学会雑誌  2015 

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  • 四肢の関節痛,易疲労感,筋力低下を主訴に受診し,抗Ku抗体陽性の多発性筋炎/強皮症オーバーラップ症候群と診断された1例

    福冨崇浩, 櫻井のどか, 西村謙一, 野澤智, 菊地雅子, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2015 

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  • 不明熱の精査中に壊血病と診断された自閉症スペクトラム障害の一男児例

    渕野恭子, 大原亜沙実, 野澤智, 櫻井のどか, 西村謙一, 菊地雅子, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2015 

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  • 少関節炎型若年性特発性関節炎(oJIA)に対してトシリズマブ(TCZ)使用中に丹毒/蜂窩織炎を合併し,治療に難渋した7歳女児例

    小野塚友里, 西村謙一, 大原亜沙実, 野澤智, 菊地雅子, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2015 

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  • 複数の筋炎特異的/関連自己抗体が陽性で多彩な臨床症状と一致した全身性強皮症の一女児例

    大原亜沙実, 西村謙一, 野澤智, 菊地雅子, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2015 

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  • 免疫グロブリン大量療法不応の川崎病に対しトシリズマブの投与を行った4例

    原良紀, 伊藤秀一, 大原亜沙実, 西村謙一, 野澤智, 宮前多佳子, 宮前多佳子, 今川智之, 今川智之, 森雅亮, 森雅亮, 岩本眞理, 岩本眞理, 横田俊平, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2015 

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  • 若年性皮膚筋炎29症例のMRI画像の検討

    櫻井のどか, 櫻井のどか, 西村謙一, 野澤智, 菊地雅子, 原良紀, 伊藤秀一, 上出浩之, 日野彩子

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2015 

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  • 全身型若年性特発性関節炎患者における,トシリズマブ無効例のプロファイル

    西村謙一, 大原亜沙実, 野澤智, 菊地雅子, 原良紀, 伊藤秀一

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2015 

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  • 川崎病に関節炎を合併した1例

    福冨崇浩, 櫻井のどか, 菊地雅子, 西村謙一, 野澤智, 原良紀, 伊藤秀一

    神奈川医学会雑誌  2015 

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  • 結節性紅斑・リベドを伴った川崎病の1例

    乙竹泰, 相原道子, 野澤智

    日本皮膚科学会雑誌  2015 

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  • 小児リウマチ性疾患における生物学的製剤の可能性 生物学的製剤の自己注射導入に向けた指導の実際及び問題点

    野澤 智, 斎藤 裕美, 島貫 利津子, 染谷 奈々子, 今川 智之

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2014.10  (一社)日本小児リウマチ学会

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  • トシリズマブを導入した高安動脈炎における,バイオマーカーの検討と画像評価の重要性

    西村謙一, 桃井貴裕, 櫻井のどか, 野澤智, 菊地雅子, 原良紀

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2014 

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  • 4か月検診で発達障害を疑われ診断に至った乳児重症結核の一例

    原良紀, 金高太一, 大原亜沙実, 渡邊季彦, 西村謙一, 野澤智, 佐藤知実, 菊地雅子, 櫻井のどか, 山崎和子, 横田俊平

    日本小児感染症学会総会・学術集会プログラム・抄録集  2014 

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  • IVIG不応の川崎病に腹部血管炎を合併し血漿交換とステロイドパルス療法を併用した1例

    高梨浩一郎, 高梨浩一郎, 菊地雅子, 西村謙一, 佐藤知実, 野澤智, 金高太一, 原良紀, 山崎和子, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2014 

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  • 血漿交換と早期の免疫抑制療法により速やかに炎症を沈静化し得た劇症型若年性皮膚筋炎の一例

    服部成良, 山崎和子, 西村謙一, 桃井貴裕, 櫻井のどか, 野澤智, 菊地雅子, 原良紀

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2014 

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  • トシリズマブ開始後に関節炎が進行した全身型若年性特発性関節炎の一男児例

    野澤 智, 西村 謙一, 佐藤 知実, 金高 太一, 櫻井 のどか, 菊地 雅子, 山崎 和子, 横田 俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2013.10  (一社)日本小児リウマチ学会

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  • Predictive Markers Of Joint Damages Of Children With Systemic-Onset Juvenile Idiopathic Arthritis In Long-Term Course Of Treatment With Tocilizumab

    Tomo Nozawa, Taichi Kanetaka, Kenichi Nishimura, Masako Kikuchi, Tomomi Sato, Nodoka Sakurai, Ryoki Hara, Kazuko Yamazaki, Shumpei Yokota

    ARTHRITIS AND RHEUMATISM  2013.10  WILEY-BLACKWELL

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    Language:English  

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  • 初発時にマクロファージ活性化症候群を呈した自己免疫性リンパ増殖症候群の1女児例

    菊地雅子, 野澤智, 金高太一, 山崎和子, 今川智之, 横田俊平, 宮前多佳子, 金兼弘和

    日本小児科学会雑誌  2013 

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  • 環境分離入院により身体機能の著明な回復が得られた若年性線維筋痛症の一女児例

    園田香里, 矢内貴憲, 藤井健太郎, 野澤智, 金高太一, 菊地雅子, 山崎和子, 今川智之, 横田俊平

    日本小児科学会雑誌  2013 

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  • 著明なHyperostosisを呈した急性骨髄性白血病(M7)の1例

    山崎和子, 野澤智, 金高太一, 檜佐香織, 菊地雅子, 藤井健太郎, 園田香里, 横須賀とも子, 今川智之, 横田俊平

    日本小児科学会雑誌  2013 

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  • EBウィルスのCD8陽性T細胞への感染を経時的に評価し治療した血球貪食症候群後の一例

    金高太一, 佐藤知実, 野澤智, 菊地雅子, 山崎和子, 今川智之, 横田俊平, 今留謙一

    日本小児科学会雑誌  2013 

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  • 異なる入院時臨床所見を呈した小児高安動脈炎の2症例~トシリズマブの治療効果

    土田哲也, 池川健, 西村謙一, 野澤智, 佐藤知実, 金高太一, 菊地雅子, 原良紀, 櫻井のどか, 山崎和子, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2013 

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  • シクロフォスファミドパルス療法とミコフェノール酸モフェチルの併用が奏功した多発筋炎の一例

    櫻井のどか, 佐藤知実, 西村謙一, 野澤智, 金高太一, 菊地雅子, 原良紀, 山崎和子, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2013 

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  • トシリズマブを用いた多関節型若年性特発性関節炎14症例の検討

    佐藤知実, 西村謙一, 野澤智, 菊地雅子, 金高太一, 櫻井のどか, 山崎和子, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2013 

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  • ガンマグロブリン(IVIG)不応でインフリキシマブ治療を施行した川崎病74例の検討

    園田香里, 藤井健太郎, 山本真由, 吉橋知邦, 檜佐香織, 野澤智, 金高太一, 菊地雅子, 山崎和子, 宮前多佳子, 今川智之, 横田俊平, 原拓麿, 森雅亮

    神奈川医学会雑誌  2013 

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  • トシリズマブを導入した難治性全身型若年性特発性関節炎の休薬条件の検討

    西村謙一, 佐藤知美, 野澤智, 金高太一, 菊地雅子, 原良紀, 櫻井のどか, 山崎和子, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2013 

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  • 若年性特発性関節炎における,18F-FDG-PET検査の有用性

    金高太一, 西村謙一, 佐藤知実, 野澤智, 菊地雅子, 原良紀, 櫻井のどか, 山崎和子, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2013 

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  • トシリズマブを用いた少関節型若年性特発性関節炎8症例の検討

    佐藤知実, 西村謙一, 野澤智, 金高太一, 原良紀, 櫻井のどか, 山崎和子, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2013 

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  • 経過中に肝に限局したマクロファージの活性化があり急性肝障害を認めた全身型若年性特発性関節炎の1例

    池川健, 山崎和子, 岩澤堅太郎, 角田知之, 西村謙一, 佐藤知美, 野澤智, 金高太一, 菊地雅子, 原良紀, 櫻井のどか, 十河剛, 乾あやの, 藤澤知雄, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2013 

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  • 抗核抗体陽性の免疫性血小板減少性紫斑病より全身性エリテマトーデスに移行した8女児例の検討

    鈴木一雄, 金高太一, 野澤智, 菊地雅子, 宮前多佳子, 今川智之, 望月博之, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2013 

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  • 治療抵抗性高安動脈炎に対するトシリズマブの効果

    山崎和子, 野澤智, 金高太一, 菊地雅子, 西村謙一, 櫻井のどか, 佐藤知美, 原良紀, 今川智之, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2013 

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  • 小児の膠原病および若年性特発性関節炎 若年性皮膚筋炎の臨床像と皮膚病理組織学的所見における11例のまとめ

    野澤 智, 金高 太一, 菊地 雅子, 木澤 敏毅, 宮前 多佳子, 今川 智之, 高橋 一夫, 横田 俊平

    日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集  2012.3  (一社)日本リウマチ学会

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    Language:Japanese  

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  • 血栓性血小板減少性紫斑病で発症し,経過中に胸水貯留と腸管浮腫,陰嚢水腫を呈したSLEの一例

    藤井健太郎, 金高太一, 木澤敏毅, 野澤智, 菊地雅子, 宮前多佳子, 今川智之, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2012 

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  • Infliximabで加療中の慢性再発性多発性骨髄炎(Chronic Recurrent Multifocal Osteomyelitis;CRMO)の男児例

    橋本邦生, 里龍晴, 本村秀樹, 森内浩幸, 永嶋早織, 野澤智, 菊地雅子, 宮前多佳子, 今川智之, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2012 

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  • 慢性炎症所見と著明なHyperostosisを呈した急性骨髄性白血病(M7)の1例:骨および骨髄の慢性炎症疾患の鑑別

    山崎和子, 野澤智, 檜佐香織, 金高太一, 菊地雅子, 園田香里, 高橋真由, 藤井健太郎, 宮前多佳子, 藤井隆成, 横須賀とも子, 今川智之, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2012 

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  • 結節性多発動脈炎寛解後にクローン病を発症しinfliximabを早期投与し有効であった一例

    園田香里, 藤井健太郎, 檜佐香織, 野澤智, 金高太一, 菊地雅子, 山崎和子, 宮前多佳子, 今川智之, 横田俊平, 関野雄典, 遠藤宏樹, 筒井美帆, 山中正二

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2012 

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  • FDG-PETを利用した若年性特発性関節炎の評価

    金高太一, 野澤智, 菊地雅子, 木澤敏毅, 宮前多佳子, 今川智之, 横田俊平

    日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集  2012 

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  • ガンマグロブリン不応でインフリキシマブ治療を施行した川崎病74例の検討

    園田香里, 野澤智, 金高太一, 菊地雅子, 山崎和子, 宮前多佳子, 今川智之, 横田俊平, 原拓麿, 森雅亮

    日本川崎病学会学術集会抄録集  2012 

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  • 環境見直し目的の2週間入院により著明な症状の改善を認めた若年性線維筋痛症の女児例

    小張真吾, 野澤智, 金高太一, 木澤敏毅, 菊池雅子, 宮前多佳子, 今川智之, 横田俊平

    日本小児科学会雑誌  2012 

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  • 若年性皮膚筋炎患者における初診時の爪郭部毛細血管顕微鏡検査所見の検討

    菊地雅子, 野澤智, 金高太一, 木澤敏毅, 宮前多佳子, 今川智之, 横田俊平

    日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集  2012 

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  • 多発リンパ節膿瘍を呈し原発性免疫不全症を疑われた1歳男児例

    山内麻衣, 林亜揮子, 野澤智, 金高太一, 菊池雅子, 木澤敏毅, 宮前多佳子, 今川智之, 横田俊平, 町田裕之

    神奈川医学会雑誌  2012 

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  • 小児ループス腎炎の寛解導入療法でのMMFとAZPのIVCYとの組み合わせにおける比較

    木澤敏毅, 野澤智, 菊地雅子, 宮前多佳子, 今川智之, 横田俊平, 原田知典

    日本小児科学会雑誌  2012 

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  • リンパ節結核との鑑別を要した左腋窩BCGリンパ節炎の1例

    原拓麿, 今川智之, 野澤智, 菊地雅子, 木澤敏毅, 宮前多佳子, 横田俊平, 山中正二, 大楠清文

    神奈川医学会雑誌  2012 

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  • 顕著な摂食障害・体重減少を呈した若年性線維筋痛症症例の検討

    宮前多佳子, 菊地雅子, 野澤智, 金高太一, 木澤敏毅, 今川智之, 横田俊平

    日本小児科学会雑誌  2012 

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  • 抗リン脂質抗体症候群を合併した亜急性壊死性リンパ節炎の一例

    金高太一, 新井千恵, 野澤智, 原拓磨, 百村芽衣, 木澤敏毅, 宮前多佳子, 今川智之, 横田俊平

    日本小児科学会雑誌  2012 

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  • EBウィルスのCD8陽性T細胞への持続感染に対し経時的な感染標的細胞の同定を行い消失を確認したEBV関連血球貪食症候群後の一例

    金高太一, 菊地雅子, 野澤智, 今川智之, 横田俊平, 今留謙一

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集  2012 

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  • Efficacy of add-on treatments of tacrolimus and methotrexate for patients with deteriorated articular manifestation of systemic-onset juvenile idiopathic arthritis during tocilizumab treatment

    Tomoyuki Imagawa, Tomo Nozawa, Takuma Hara, Masako Kikuchi, Mei Momomura, Toshiki Kizawa, Takako Miyamae, Masaaki Mori, Shumpei Yokota

    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY  2011.3  CLINICAL & EXPER RHEUMATOLOGY

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    Language:English  

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  • 小児例におけるパンデミック(H1N1)2009と季節型インフルエンザA型の臨床的検討

    野澤 智, 内田 理, 森 雅亮, 鏑木 陽一, 城 裕之, 横田 俊平

    日本小児科学会雑誌  2011.2  (公社)日本小児科学会

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    Language:Japanese  

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  • 有効血中濃度に得るためにTocilizumabの頻回の投与を要した全身型若年性特発性関節炎の2歳女児

    原拓麿, 野澤智, 菊地雅子, 原良紀, 百村芽衣, 木澤敏毅, 宮前多佳子, 今川智之, 吉田さやか, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2011 

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  • 筋炎症状を呈した慢性再発性多発性骨髄炎(Chronic recurrent multifocal osteomyelitis;CRMO)の男児例

    永嶋早織, 野澤智, 菊地雅子, 橋本邦生, 木澤敏毅, 宮前多佳子, 今川智之, 稲山嘉明, 相田典子, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2011 

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  • 経過中に複雑な臨床症状を呈し治療に難渋した混合性結合組織病の1女児例~早期全身評価と適切な治療導入の重要性~

    菊地雅子, 野澤智, 原拓麿, 木澤敏毅, 宮前多佳子, 今川智之, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2011 

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  • 急速に進行する筋力低下に対して血漿交換とエンドキサンパルスの併用療法が奏功した抗SRP抗体陽性多発筋炎の一例

    百村芽衣, 百村芽衣, 野澤智, 原拓麿, 菊地雅子, 木澤敏毅, 宮前多佳子, 今川智之, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2011 

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  • 結核感染におけるQuantiFERON-TB Goldの有用性

    原拓麿, 新井千恵, 野澤智, 門田景介, 安藤敏子, 菊地雅子, 原良紀, 宮前多佳子, 今川智之, 横田俊平

    日本小児科学会雑誌  2011 

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  • Sclerotic fibromaと診断した1例

    大澤研子, 大川智子, 野澤智, 猪又直子, 和田秀文, 池澤善郎, 長濱清隆, 毛利忍, 松村恵理子

    日本皮膚科学会雑誌  2011 

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  • 心外膜炎・心筋炎で発症した全身性エリテマトーデスの一例

    西村謙一, 新井千恵, 野澤智, 原拓麿, 菊地雅子, 木澤敏毅, 百村芽衣, 宮前多佳子, 今川智之, 横田俊平

    神奈川医学会雑誌  2011 

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  • 小児おけるQunati FERO TB Gold陽性となった8例の臨床像の検討

    原拓麿, 野澤智, 原良紀, 木澤俊毅, 宮前多佳子, 今川智之, 森雅亮, 横田俊平

    日本小児感染症学会総会・学術集会プログラム・抄録集  2011 

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  • インフリキシマブを使用し寛解後に関節炎を認めた難治性川崎病の2例

    岸崇之, 野澤智, 百村芽衣, 坂内優子, 宮前多佳子, 今川智之, 横田俊平, 大澤真木子

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2011 

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  • 皮膚白血球破砕型血管炎の1例

    若宮卓也, 藤原祐, 小林可奈, 佐藤睦美, 村田宗紀, 鈴木剛, 譲原佐栄子, 山口和子, 斎藤千穂, 田中文子, 高橋浩之, 甲斐純夫, 野澤智, 今川智之, 横田俊平

    神奈川医学会雑誌  2011 

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  • 小児期ループス腎炎の寛解導入療法におけるミコフェノール酸モフェチルとアザチオプリンとのシクロフォスファミドパルス療法との組合せにおける比較

    木澤敏毅, 野澤智, 菊地雅子, 宮前多佳子, 今川智之, 横田俊平, 原田知典

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2011 

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  • 心外膜炎,心筋炎で発症した全身性エリテマトーデスの一例

    西村謙一, 新井千恵, 野澤智, 原拓麿, 菊地雅子, 木澤敏毅, 百村芽衣, 宮前多佳子, 今川智之, 横田俊平

    日本小児リウマチ学会総会・学術集会プログラム・抄録集  2011 

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  • 発熱を認めず腹痛のみの経過にて診断された家族性地中海熱の1例

    木澤敏毅, 野澤智, 原拓麿, 菊地雅子, 百村芽衣, 宮前多佳子, 今川智之, 横田俊平, 小林基章, 十河剛

    日本小児科学会雑誌  2011 

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  • 小児の遷延性咳嗽に対する横浜医療センター小児科での評価と治療

    野澤 智

    化学療法の領域  2010.3  (株)医薬ジャーナル社

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    Language:Japanese  

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  • 児童虐待に対する基幹病院の役割と地域連携の現状

    鏑木陽一, 石津博子, 及川茂輝, 野澤智, 塩谷裕美, 藤塚麻子, 小郷寛史, 長濱晶子, 小林慈典, 菅井和子

    日本小児科学会雑誌  2010 

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  • 異なる経過をたどった十二指腸潰瘍の2例

    石津博子, 及川茂輝, 野澤智, 塩谷裕美, 藤塚麻子, 小郷寛史, 長濱晶子, 小林慈典, 菅井和子, 鏑木陽一

    日本小児科学会雑誌  2010 

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  • 浴槽用浮き輪の転覆による乳児の溺水事故2例

    小郷寛史, 石津博子, 本井宏尚, 及川茂輝, 野澤智, 塩谷裕美, 藤塚麻子, 長濱晶子, 小林慈典, 菅井和子, 鏑木陽一, 大山宜孝

    神奈川医学会雑誌  2010 

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  • 気管支喘息児の経過判定における気道過敏性検査,FeNO値の検討

    塩谷裕美, 菅井和子, 野澤智, 藤塚麻子, 只木弘美, 小林慈典, 鏑木陽一, 横田俊平

    アレルギー  2010 

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  • 再発を繰り返した芽球NK細胞リンパ腫の1例

    野澤智, 瀬川郁雄, 佐藤賢, 宮入泰郎, 佐熊勉

    日本皮膚科学会雑誌  2010 

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  • 口腔アレルギー症候群の有病率の検討

    野澤 智, 鈴木 剛, 小笹 浩二, 神山 明美, 川口 葉子, 奥 典宏, 相原 雄幸, 横田 俊平

    食物アレルギー研究会会誌  2009.10  食物アレルギー研究会

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    Language:Japanese  

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  • 当科におけるFPIESが疑われた5例の臨床像

    塩谷裕美, 菅井和子, 鈴木健, 野澤智, 和田芳雅, 藤塚麻子, 小林慈典, 鏑木陽一

    アレルギー  2009 

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  • 地域基幹病院における気管支喘息児に対する気道過敏性検査の有用性

    藤塚麻子, 菅井和子, 鈴木健, 野澤智, 塩谷裕美, 小郷寛史, 長濱晶子, 小林慈典, 只木弘美, 鏑木陽一

    日本小児科学会雑誌  2009 

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  • 小児気管支喘息患者における気道過敏性検査とFeNOの関係

    塩谷裕美, 菅井和子, 鈴木健, 野澤智, 藤塚麻子, 只木弘美, 小林慈典, 鏑木陽一, 横田俊平

    アレルギー  2009 

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  • 非侵襲的人工呼吸器(BIPAP)マスク装着時の皮膚保護材の検討

    柏木裕樹, 小比類巻敦子, 野澤智子, 青木美香, 菅谷歩未

    国立病院総合医学会講演抄録集  2009 

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  • ステロイドパルス療法が著効したサルモネラ脳症の1例

    梶谷聡子, 鈴木剛, 野澤智, 海老名奏子, 堤晶子, 稲葉彩, 市川和志, 志賀健太郎, 武下草生子, 伊藤秀一, 森雅亮, 菊池信行, 相原雄幸, 横田俊平

    神奈川医学会雑誌  2009 

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  • 診断に頸部エコー,頸部MRIが有用であった亜急性壊死性リンパ節炎の2例

    塩谷裕美, 小林慈典, 野澤智, 菅井和子, 鏑木陽一, 原良紀, 今川智之, 横田俊平

    日本小児感染症学会総会・学術集会プログラム・抄録集  2009 

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  • IgA,IgG4欠損症を伴ったPFAPA症候群の1例

    小林慈典, 野澤智, 塩谷裕美, 菅井和子, 鏑木陽一, 原良紀, 今川智之, 森雅亮, 横田俊平

    日本小児感染症学会総会・学術集会プログラム・抄録集  2009 

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  • 診断に苦慮した抗MuSK抗体陽性重症筋無力症の一例

    宮下和甫, 武下草生子, 鈴木剛, 野澤智, 海老名奏子, 堤晶子, 稲葉彩, 市川和志, 志賀健太郎, 伊藤秀一, 森雅亮, 菊池信行, 相原雄幸, 横田俊平, 本村政勝

    神奈川医学会雑誌  2009 

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  • 乳幼児期におけるRSウィルス感染後の気管支喘息発症のリスク因子

    藤塚麻子, 菅井和子, 鈴木健, 野澤智, 塩谷裕美, 只木弘美, 小林義典, 鏑木陽一

    日本小児アレルギー学会誌  2009 

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  • 神経麻痺症状を呈しMRIにて広範な異常所見を認めたSLEの1例

    原良紀, 野澤智, 佐野史絵, 笠井和子, 金子詩子, 篠木敏彦, 宮前多佳子, 今川智之, 森雅亮, 横田俊平

    日本小児科学会雑誌  2008 

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  • 十二指腸乳頭部癌 多発肝転移の一剖検例

    野澤智, 藤原隆雄, 三浦達也, 大森信弥, 吉田雅美, 池端敦, 小野満, 村上晶彦, 佐熊勉, 小野貞英, 冨地信和, 朝倉慎一

    岩手医学雑誌  2008 

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  • インフリキシマブが著効した壊疽性膿皮症の1例

    野澤智, 原良紀, 佐野史絵, 木下順平, 宮前多佳子, 今川智之, 森雅亮, 横田俊平, 廣門未知子, 高橋一夫, 金子聡

    神奈川医学会雑誌  2008 

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Awards

  • 2018年度留学補助金

    2018.11   公益財団法人持田記念医学薬学振興財団  

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  • 第2回倶進会留学基金

    2018.3   倶進会  

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  • 2017年度日本アレルギー学会海外研究留学助成金

    2017.6   日本アレルギー学会  

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Research Projects

  • Analysis and therapeutic research for growth impairment accompanied with chronic inflammatory syndrome of children as dysregulation of proinflammatory cytokines

    Grant number:23591546  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YOKOTA Shumpei, IMAGAWA Tomoyuki, MIYAMAE Takako, KIKUCHI Masako, NOZAWA Tomo

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    Grant amount:\5200000 ( Direct Cost: \4000000 、 Indirect Cost:\1200000 )

    Growth impairment accompanied with systemic juvenile idiopathic arthritis (sJIA) is thought to be associated with suppression of proliferation of chondrocyte by IL-6, the key cytokine causing systemic inflammation, and suppression of bone extension by corticosteroid. Tocilizumab, anti-IL-6 receptor antibody, was approved in 2008 in Japan, so now bloadly used as treatment for steroid-refractory or -dependent sJIA. We have investigated height and height velocity of 45 sJIA patient administered with TCZ and analyzed correlation between them and several factors such as age, gender, disease duration and corticosteroid exposure, then inverse correlation between standard deviation score for height (HTSDS) and disease duration and strong correlation between reduction of corticosteroid and improvement of height velocity.

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