Updated on 2026/03/13

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写真a

 
Makoto Sasaki
 
Organization
Yokohama City University Hospital Anesthesiology Assistant Professor
Title
Assistant Professor
Profile

・新生児の呼吸管理

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Degree

  • 学士(医学) ( 東京医科歯科大学 )

Research Interests

  • 心臓血管麻酔

Research Areas

  • Life Science / Anesthesiology

Research History

  • 横浜市立大学 医学研究科博士課程

    2023.4

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  • Yokohama City University School of Medicine Medical Course   Assistant Professor

    2017.4

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Papers

  • Anesthesia during delivery in pregnant women with dilated cardiomyopathy International journal

    Makoto Sasaki, Yoshihiko Ohnishi

    Medicine   102 ( 11 )   e33277   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    Emergency cesarean delivery in patients with heart failure increases maternal and fetal mortality. The present study aimed to identify the relationship between the use of anesthesia for delivery and progressive cardiac deterioration in women with dilated cardiomyopathy (DCM) and to examine its implications on maternal and fetal outcomes. Twenty-nine pregnancies in 25 women with DCM from the National Cerebral and Cardiovascular Center Hospital (Suita, Japan) were included in this retrospective longitudinal study. Fourteen of the patients (48.3%) delivered via cesarean section. Among these, 4 patients (13.8%) experienced heart failure within 42 days of delivery. The indication for cesarean delivery was heart failure in 3 patients and induction failure in 1 patient. The types of anesthesia used for these patients included general (n = 1), combined spinal-epidural (n = 2), and epidural (n = 1). Two of these cesarean deliveries were performed preterm. The left ventricular ejection fraction of patients with heart failure was ≤ 35% before 34 weeks gestation. Among the 25 patients without heart failure, 2 exhibited a left ventricular ejection fraction of ≤ 35% before 34 weeks gestation. Meanwhile, the types of anesthesia used for remaining 10 patients who did not experience heart failure included general (n = 1), combined spinal-epidural (n = 8), and epidural (n = 1). The rate of general anesthesia was 25% in patients who experienced heart failure and 4% in others. There was no incidence of maternal or fetal death. A preterm anesthetic evaluation may be warranted to optimize anesthetic management when the ejection fraction decreases to ≤ 35% before 34 weeks gestation in patients with DCM.

    DOI: 10.1097/MD.0000000000033277

    PubMed

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  • Simulation of pressure support for spontaneous breathing trials in neonates

    Makoto Sasaki, Yoshikazu Yamaguchi, Tetsuya Miyashita, Yuko Matsuda, Masahide Ohtsuka, Osamu Yamaguchi, Takahisa Goto

    Intensive Care Medicine Experimental   7 ( 1 )   2019.12

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1186/s40635-019-0223-8

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    Other Link: http://link.springer.com/article/10.1186/s40635-019-0223-8/fulltext.html

Books

  • 周術期気道・呼吸管理の基礎と実際

    佐々木 誠( Role: Contributor重症筋無力症患者の縦隔手術(その他神経筋疾患))

    克誠堂出版  2021.5  ( ISBN:9784771905511

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MISC

Research Projects

  • 低酸素曝露動物モデルにおいてT型Caチャネル阻害剤に胎児遺伝子抑制作用はあるか

    Grant number:20K17089  2020.4 - 2025.3

    日本学術振興会  科学研究費助成事業  若手研究

    佐々木 誠

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    成体を低酸素環境におくと, 胎児遺伝子の再活性化によりT型カルシウムチャネルが再発現し, 心筋のリモデリングや不整脈の原因となる. また, 副腎ではカテ コラミンの分泌が亢進する. 本研究では, T型カルシウムチャネル阻害剤が副腎からのカテコラミンの分泌を抑制し, 心臓のリモデリングや不整脈を予防することを示す.

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