Updated on 2026/03/11

All information, except for affiliations, is reprinted from the information registered on researchmap.

写真a

 
Hiromasa Kawakami
 
Organization
YCU Medical Center Operation Department Associate Professor
Title
Associate Professor
Homepage
http://www.yokohama-cu.ac.jp/urahp/section/anesthetize/index.html
External link

Research Interests

  • 内因性NOS阻害物質

  • 肺高血圧

  • 肺高血圧症

  • プラスミドベクター

  • VIP

  • 心拍出量

  • PACAP

  • CPI-17

  • HO-1

  • 心肥大

  • lentivirus

  • ＰＲＭＴ２

  • desensitization

  • H0-1

  • エレクトロポレーション

  • MLCK

  • ＶＰＡＣ２

  • 先天性肺疾患

  • 先天性心疾患

  • PAC1受容体

  • PACAP/VIP

  • レンチウイルス

  • ＤＤＡＨ１

  • 心臓神経叢

  • 肺血管平滑筋

  • レンチウイルスベクター

Research Areas

  • Life Science / Anesthesiology

Research History

  • Yokohama City University Medical Center Anesthesiology   Assistant Professor

    2015.12 - 2016.3

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  • Yokohama City University   Assistant Professor

    2011.4 - 2015.11

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  • -

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Papers

  • Enhancement of the capacity of a healthcare team through real-time information-sharing using a wireless intercom system: a prospective simulation study. International journal

    Hitoshi Sato, Daisuke Kuwabara, Kazuhiro Minoguchi, Tetsuhito Masubuchi, Miho Matsumoto, Yuka Okuyama, Hiromasa Kawakami, Takeru Abe, Kyota Nakamura, Takahisa Goto, Kazue Nakajima

    BMJ open   16 ( 2 )   e099979   2026.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVES: Rising patient numbers and limited resources are creating a challenging environment for healthcare providers recently. Anaesthesiologists are also increasingly faced with complex situations, requiring high adaptability in the operating room. To enhance team adaptability during emergencies, effective communication methods are essential. This study aimed to compare the impact of mobile phones and intercoms on the response time and effectiveness of anaesthesiologist teams in emergency situations. DESIGN: Prospective, observational and simulation study. SETTING: Anaesthesiology and Critical Care, Yokohama City University Medical Center, Yokohama, Japan. PARTICIPANTS AND METHODS: This study, conducted at Yokohama City University Medical Center (Yokohama, Japan), evaluated how communication methods (intercoms vs mobile phones) impact the efficiency of anaesthesiologists in the simulation setting. Two scenarios were tested: (1) retrieving a video laryngoscope during a difficult intubation and (2) gathering support during cardiac arrest. PRIMARY AND SECONDARY OUTCOME MEASURES: Outcomes measured included time to secure equipment, time for assistance to arrive and staff numbers gathered. The Wilcoxon signed-rank test was used to compare the outcomes between the intercom and mobile phone groups. RESULTS: In scenario 1, the time to secure the video laryngoscope was significantly shorter with intercom use compared with mobile phones (intercom vs mobile phone, median (IQR): 29 (25-33) s vs 50 (39-62) s; p=0.013, effect size 20 (95% CI 7 to 31)). In scenario 2, the time from the request for assistance until the first supporting staff member reached the operating room was significantly shorter in using the intercoms (intercom vs mobile phone, median (IQR): 16 (14-18) s vs 35 (31-38) s; p=0.04, effect size 17 (95% CI 6 to 24)), and more personnel were available in the intercom group (intercom vs mobile phone, median (IQR): 3 (3-3.5) persons vs 2 (1-2) persons; p=0.04, effect size 1.5 (95% CI 1 to 3)). CONCLUSION: Real-time information sharing through intercoms improved the ability of the anaesthesiologist team to respond more rapidly and effectively in emergency situations, enhancing overall team adaptability. This approach may improve patients' outcomes by shortening response times and increasing team coordination.

    DOI： 10.1136/bmjopen-2025-099979

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  • Granisetron for prevention of postoperative shivering in surgical patients: a systematic review and meta-analysis. International journal

    Tetsuhito Masubuchi, Kazuhiro Minoguchi, Hiromasa Kawakami, Takahiro Mihara, Hitoshi Sato, Takahisa Goto

    BMC anesthesiology   25 ( 1 )   469 - 469   2025.9

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    BACKGROUND: 5-HT3 receptor antagonists, including granisetron, have demonstrated antiemetic effects and the ability to prevent perioperative shivering. We conducted a systematic review of randomized clinical trials to investigate granisetron’s preventive effects on shivering in surgical patients undergoing general or neuraxial anesthesia. METHODS: We searched PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials from inception to January 7, 2025, without language restrictions, and simultaneously searched study protocols in four registries. Randomized controlled trials comparing granisetron versus placebo in surgical patients were included. We excluded studies in which patients underwent surgeries with cardiopulmonary bypass or in which patients were not expected to be extubated after surgery. The primary outcome was the incidence of shivering, calculated as a risk ratio with 95% CI using a random-effects model. A trial sequential analysis (TSA) of the primary outcome was performed to reduce type 1 errors from repeated meta-analyses, calculating the required information size. The risk of bias was assessed using the Revised Cochrane risk of bias 2 tool. RESULTS: Twenty-four trials, totaling 2,165 patients (1,166 and 999 patients in the granisetron and control groups, respectively), were included. Our meta-analysis showed a significantly lower incidence of shivering in surgical patients who received granisetron (risk ratio, 0.34; 95% CI, 0.28–0.41; I2 = 9%). The Grading of Recommendation Assessment, Development, and Evaluation assessment for granisetron’s effect on shivering prevention was moderate. When only low risk-of-bias trials were included, the Z-cumulative curve crossed the TSA boundary of benefit, confirming a significant reduction in shivering incidence in the granisetron group. The optimal granisetron dose, however, remains unclear in this meta-analysis. CONCLUSION: Our meta-analysis and TSA demonstrated that granisetron administration significantly reduced the incidence of shivering in patients undergoing surgery. While evidence regarding the general effect of granisetron on shivering is extensive, future studies should focus on determining the optimal dosage. TRIAL REGISTRATION: This meta-analysis is registered on PROSPERO(CRD42024616645). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12871-025-03348-9.

    DOI： 10.1186/s12871-025-03348-9

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  • Enhancing the quality and safety of central venous catheter insertion using projection mapping: a prospective observational simulation study with eye-tracking glasses. International journal

    Atsushi Miyazaki, Arisa Fujii, Daisuke Kuwabara, Kazuhiro Minoguchi, Hiromasa Kawakami, Kyota Nakamura, Keiko Tsuchiya, Takeru Abe, Kazue Nakajima, Hitoshi Sato, Takahisa Goto

    BMJ open   15 ( 5 )   e095803   2025.5

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    OBJECTIVES: We aimed to evaluate the effect of projection mapping (PM) on the quality and safety of central venous catheter (CVC) insertion under real-time ultrasound guidance. DESIGN: Prospective, observational, simulation study. SETTING: This study was conducted at the Yokohama City University Medical Center (Yokohama, Japan). Volunteer residents were enrolled over 12 months from January to December 2023. PARTICIPANTS AND METHODS: 12 rotating residents (postgraduation year (PGY) 1 and 2) and eight anaesthesia residents (PGY 3-5) placed the CVC in the internal jugular vein in a simulator under the real-time ultrasound guidance using the short-axis out-of-plane approach. The ultrasound image was provided either just caudad to the puncture site using the PM method or on the monitor of the ultrasound machine (conventional method) placed next to the simulator's right shoulder. Each resident performed four punctures alternating between the PM and conventional methods, and the first method for each resident was chosen randomly. Eye-tracking analysis was also used to evaluate differences in gaze behaviour. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the procedure time defined as the time from the application of the ultrasound probe on the puncture field until successful puncture of the vein. The secondary outcomes were incidence of complications and eye-tracking analysis data. RESULTS: The time to complete the line placement was significantly shorter for the PM than for the conventional method (median (IQR) 22.5 (15.5-30.6) s vs 30.0 (20.4-95.4) s; p=0.02, Wilcoxon's signed-rank test). The incidence of posterior vessel wall puncture was significantly lower in the PM method (0% vs 25%; p=0.02, McNemar's test). Eye-tracking analysis revealed that the percentage of time spent gazing at the ultrasound image was higher in the PM than in the conventional method (61.6% (55.0-69.2) vs 45.7% (34.1-54.5); p<0.01). CONCLUSIONS: The PM method facilitates ultrasound-guided CVC placement while preventing excessive needle advancement in the inexperienced operators. This was accompanied by enhanced fixation of the participants' line-of-sight on the ultrasound image.

    DOI： 10.1136/bmjopen-2024-095803

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  • Comparison between nurse anesthetists and anesthesiology residents of blood pressure management during general anesthesia: a retrospective analysis using an electronic anesthesia record database. International journal

    Arisa Fujii, Marie Miyamori, Hirokazu Shiba, Takeru Abe, Hiromasa Kawakami, Hitoshi Sato, Takahisa Goto

    BMC anesthesiology   25 ( 1 )   206 - 206   2025.4

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    BACKGROUND: Several Japanese educational institutions have begun to train nurse anesthetists. They manage the patient consistently from pre-operation to post-operation in collaboration with the anesthesiologist. This has helped improve the quality of anesthetic management in an anesthesiologist shortage environment in Japan. However, no studies have examined the quality of anesthetic management by nurses worldwide. Therefore, this study investigated the quality of anesthesia among novice anesthesiology residents and nurse anesthetists, focusing on blood pressure control. METHODS: This study included adult patients undergoing breast surgery. Nurse anesthetists or anesthesiology residents oversaw general anesthesia. Intraoperative electronic medical records were used to compare the general anesthesia management of nurses and residents. The primary outcome was the sum of the duration during which the mean blood pressure was < 65 mmHg. This was quantified as a percentage of the total anesthesia time (time under mean 65 mmHg: TUm65). Independent variables included patient demographic characteristics, clinical information, the percentage decrease from baseline in the lowest mean blood pressure during anesthesia, and the hourly infusion volume. RESULTS: No significant difference was observed in the TUm65 (nurse anesthetists vs. anesthesiology residents: median [IQR] 11.3% [3.3-20.7] vs. 18.1% [5.3-24.0], p = 0.078). No significant differences were noted between nurses and residents concerning the other outcomes. CONCLUSION: No significant differences were observed in the intraoperative blood pressure control between the nurse anesthetists and anesthesia residents.

    DOI： 10.1186/s12871-025-03080-4

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  • Effects of wearing surgical masks on fraction of inspired oxygen in spontaneously breathing patients: improving safety for frontline healthcare professionals under pandemic situations. International journal

    Kazuhiro Minoguchi, Akira Isii, Toshiki Nakamura, Hitoshi Sato, Takeru Abe, Hiromasa Kawakami, Kyota Nakamura, Takahisa Goto

    BMC anesthesiology   22 ( 1 )   108 - 108   2022.4

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    BACKGROUND: During pandemic situations, many guidelines recommend that surgical masks be worn by both healthcare professionals and infected patients in healthcare settings. The purpose of this study was to clarify the levels and changes of oxygen concentration over time while oxygen was administered over a surgical mask. METHODS: Patients scheduled to undergo general anesthesia (n = 99) were enrolled in this study. First, patients were administered oxygen at 6 L/min via an oxygen mask over a surgical mask for 5 min. The patients removed the surgical mask and then took a 3-min break; thereafter, the same amount of oxygen was administered for another 5 min via the oxygen mask. We measured the fraction of inspired oxygen (FiO2), the end-tidal CO2 (EtCO2), and respiratory frequency every minute for 5 min, both while administering oxygen with and without a surgical mask. The FiO2 was measured at the beginning of inspiration and the EtCO2 was measured at the end of expiration. RESULTS: The FiO2 at 5 min was significantly lower when breathing with a surgical mask than that without it (mean difference: 0.08 [95% CI: 0.067-0.10]; p <  0.001). In contrast, the EtCO2 at 5 min was significantly higher when breathing with a surgical mask than that without it (mean difference: 11.9 mmHg [95% CI: 10.9-12.9]; p <  0.001). CONCLUSION: The FiO2 was lower when oxygen was administered over surgical masks than when patients did not wear surgical masks. Oxygen flow may need to be adjusted in moderately ill patients requiring oxygen administration.

    DOI： 10.1186/s12871-022-01649-x

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  • Impact of anesthetic agents on the amount of bleeding during dilatation and evacuation: A systematic review and meta-analysis. International journal

    Hyun Ah Lee, Hiromasa Kawakami, Takahiro Mihara, Hitoshi Sato, Takahisa Goto

    PloS one   16 ( 12 )   e0261494   2021

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    PURPOSE: Patients undergo dilatation and evacuation for abortion or miscarriage. However, bleeding is sometimes problematic. Despite reports on the association between volatile anesthetics and increased bleeding during the procedure, firm evidence is lacking. Therefore, we conducted a systematic review and meta-analysis to compare the effects of volatile anesthetics and propofol on the amount of bleeding in patients undergoing dilatation and evacuation. METHODS: We conducted a systematic search of four databases, namely PubMed, Embase, Cochrane Central Register of Controlled Trials databases, and Web of Science (Clarivate Analytics), from their respective inception to April 2021. Moreover, we searched two trial registration sites. The inclusion criterion was randomized controlled trials of patients who underwent dilatation and evacuation under general anesthesia using volatile anesthetics or propofol. The primary outcome was the amount of perioperative bleeding. The mean difference of the bleeding was combined using a random-effects model. The I2 statistic was used to assess heterogeneity. We assessed risk of bias with Cochrane domains. We controlled type I and II errors due to sparse data and repetitive testing with Trial Sequential Analysis. We assessed the quality of evidence with GRADE. RESULTS: Five studies were included in the systematic review. The amount of bleeding was compared in four studies and was higher in the volatile anesthetic group, with a mean difference of 164.7 ml (95% confidence interval, 43.6 to 285.7; p = 0.04). Heterogeneity was considerable, with an I2 value of 97%. Two studies evaluated the incidence of significant bleeding, which was significantly higher in the volatile anesthetic group (RR, 2.42; 95% confidence interval, 1.04-5.63; p = 0.04). CONCLUSION: Choosing propofol over volatile anesthetics during dilatation and evacuation might reduce bleeding and the incidence of excessive bleeding. However, the quality of the evidence was very low. This necessitates further trials with a low risk of bias. TRIAL REGISTRATION: PROSPERO (CRD42019120873).

    DOI： 10.1371/journal.pone.0261494

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  • Effectiveness of intravenous lidocaine in preventing postoperative nausea and vomiting in pediatric patients: A systematic review and meta-analysis. Reviewed International journal

    Daisuke Nakajima, Hiromasa Kawakami, Takahiro Mihara, Hitoshi Sato, Takahisa Goto

    PloS one   15 ( 1 )   e0227904   2020

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    BACKGROUND: Intravenous lidocaine in adults undergoing general anesthesia has been shown to reduce the incidence of postoperative nausea and vomiting (PONV). However, the anti-postoperative vomiting (POV) effect of lidocaine in pediatric patients remains unclear. We conducted a systematic review and meta-analysis with Trial Sequential Analysis to evaluate the effect of intravenous lidocaine on prevention of POV/PONV. METHODS: Six databases including trial registration sites were searched. Randomized clinical trials evaluating the incidence of POV/PONV after intravenous lidocaine compared with control were included. The primary outcome was the incidence of POV within 24 hours after general anesthesia. The incidence of POV was combined as a risk ratio with 95% confidence interval using a random-effect model. We used the I2 to assess heterogeneity. We evaluated the quality of trials using the Cochrane methodology, and we assessed quality of evidence using the Grading of Recommendation Assessment, Development, and Evaluation approach. We also assessed adverse events. RESULTS AND DISCUSSION: Six trials with 849 patients were included, of whom 433 received intravenous lidocaine. Three trials evaluated the incidence of POV, and 3 evaluated the incidence of PONV. The overall incidence of POV within 24 hours after anesthesia was 45.9% in the lidocaine group and 63.4% in the control group (risk ratio, 0.73; 95% confidence interval, 0.53-1.00; I2 = 32%; p = 0.05). The incidence of PONV within 24 hours after anesthesia was 3.73% in the lidocaine group and 4.87% in the control group (RR, 0.76; 95% CI, 0.36-1.59; I2 = 0%; p = 0.47). The quality of evidence was downgraded to "very low" due to the study designs, inconsistency, imprecision, and possible publication bias. CONCLUSION: Our meta-analysis suggests that intravenous lidocaine infusion may reduce the incidence of POV, however, the evidence quality was "very low." Further trials with a low risk of bias are necessary.

    DOI： 10.1371/journal.pone.0227904

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  • 周麻酔期看護師が施行した全身麻酔の患者循環動態は、麻酔科医が施行した場合とで異なるのか? 循環動態から考察する周麻酔期看護師の麻酔の質

    佐藤 仁, 安部 猛, 大須賀 明里, 川上 裕理, 後藤 隆久

    医療の質・安全学会誌   14 ( Suppl. )   478 - 478   2019.11

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  • Effectiveness of Magnesium in Preventing Shivering in Surgical Patients: A Systematic Review and Meta-analysis. Reviewed International journal

    Hiromasa Kawakami, Daisuke Nakajima, Takahiro Mihara, Hitoshi Sato, Takahisa Goto

    Anesthesia and analgesia   129 ( 3 )   689 - 700   2019.9

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    BACKGROUND: Clinical trials regarding the antishivering effect of perioperative magnesium have produced inconsistent results. We conducted a systematic review and meta-analysis with Trial Sequential Analysis to evaluate the effect of perioperative magnesium on prevention of shivering. METHODS: We searched PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, and 2 registry sites for randomized clinical trials that compared the administration of magnesium to a placebo or no treatment in patients undergoing surgeries. The primary outcome of this meta-analysis was the incidence of shivering. The incidence of shivering was combined as a risk ratio with 95% CI using a random-effect model. The effect of the route of administration was evaluated in a subgroup analysis, and Trial Sequential Analysis with a risk of type 1 error of 5% and power of 90% was performed. The quality of each included trial was evaluated, and the quality of evidence was assessed using the Grading of Recommendation Assessment, Development, and Evaluation approach. We also assessed adverse events. RESULTS: Sixty-four trials and 4303 patients (2300 and 2003 patients in magnesium and control groups, respectively) were included. The overall incidence of shivering was 9.9% in the magnesium group and 23.0% in the control group (risk ratio, 0.42; 95% CI, 0.33-0.52). Subgroup analysis revealed that the incidence of shivering was lower with IV (risk ratio, 0.29; 95% CI, 0.29-0.54; Grading of Recommendation Assessment, Development, and Evaluation, moderate), epidural (risk ratio, 0.24; 95% CI, 0.13-0.43; Grading of Recommendation Assessment, Development, and Evaluation, low), and intrathecal administration (risk ratio, 0.64; 95% CI, 0.43-0.96; Grading of Recommendation Assessment, Development, and Evaluation, moderate). Only trials with low risk of bias were included for Trial Sequential Analysis. The Z-cumulative curve for IV magnesium crossed the Trial Sequential Analysis monitoring boundary for benefit even though only 34.9% of the target sample size had been reached. The Z-cumulative curve for epidural or intrathecal administration did not cross the Trial Sequential Analysis monitoring boundary for benefit. No increase in adverse events was reported. CONCLUSIONS: Perioperative IV administration of magnesium effectively reduced shivering and Trial Sequential Analysis suggested that no more trials are required to confirm that IV magnesium effectively reduces shivering.

    DOI： 10.1213/ANE.0000000000004024

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  • Effectiveness of Magnesium in Preventing Shivering in Surgical Patients: A Systematic Review and Meta-analysis. Reviewed

    Kawakami H, Nakajima D, Mihara T, Sato H, Goto T

    Anesthesia and analgesia   2019.2

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  • Effect of magnesium added to local anesthetics for caudal anesthesia on postoperative pain in pediatric surgical patients: A systematic review and meta-analysis with Trial Sequential Analysis. Reviewed International journal

    Hiromasa Kawakami, Takahiro Mihara, Nobuhito Nakamura, Koui Ka, Takahisa Goto

    PloS one   13 ( 1 )   e0190354   2018

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    BACKGROUND: Magnesium has been investigated as an adjuvant for neuraxial anesthesia, but the effect of caudal magnesium on postoperative pain is inconsistent. The aim of this systematic review and meta-analysis was to evaluate the analgesic effect of caudal magnesium. METHODS: We searched six databases, including trial registration sites. Randomized clinical trials reporting the effect of caudal magnesium on postoperative pain after general anesthesia were eligible. The risk ratio for use of rescue analgesics after surgery was combined using a random-effects model. We also assessed adverse events. The I2 statistic was used to assess heterogeneity. We assessed risk of bias with Cochrane domains. We controlled type I and II errors due to sparse data and repetitive testing with Trial Sequential Analysis. We assessed the quality of evidence with GRADE. RESULTS: Four randomized controlled trials (247 patients) evaluated the need for rescue analgesics. In all four trials, 50 mg of magnesium was administered with caudal ropivacaine. The results suggested that the need for rescue analgesia was reduced significantly by caudal magnesium administration (risk ratio 0.45; 95% confidence interval 0.24-0.86). There was considerable heterogeneity as indicated by an I2 value of 62.5%. The Trial Sequential Analysis-adjusted confidence interval was 0.04-5.55, indicating that further trials are required. The quality of evidence was very low. The rate of adverse events was comparable between treatment groups. CONCLUSION: Caudal magnesium may reduce the need for rescue analgesia after surgery, but further randomized clinical trials with a low risk of bias and a low risk of random errors are necessary to assess the effect of caudal magnesium on postoperative pain and adverse events. TRIAL REGISTRATION: University Hospital Medical Information Network Clinical Trials Registry UMIN000025344.

    DOI： 10.1371/journal.pone.0190354

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  • Effect of an Intravenous Dexamethasone Added to Caudal Local Anesthetics to Improve Postoperative Pain: A Systematic Review and Meta-analysis With Trial Sequential Analysis Reviewed

    Hiromasa Kawakami, Takahiro Mihara, Nobuhito Nakamura, Koui Ka, Takahisa Goto

    ANESTHESIA AND ANALGESIA   125 ( 6 )   2072 - 2080   2017.12

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  • Behavior of Anesthesiology Residents in a Situation of Intravenous Route Occlusion During Syringe Pump Use in a Simulated Intensive Care Unit. Reviewed International journal

    Kariya T, Miyashita T, Sato H, Kawakami H, Goto T

    Journal of patient safety   15 ( 4 )   290 - 292   2017.11

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    INTRODUCTION: Unintentional catecholamine flush caused by inappropriate release of an intravenous occlusion during use of a syringe pump in the intensive care unit (ICU) can have dangerous consequences in patients receiving critical care. We investigated whether anesthesiology residents understood how to deal with syringe pump occlusion in a simulated ICU setting. METHODS: We set up a mannequin that virtually simulated a sedated patient under mechanical ventilation after cardiac surgery, with epinephrine and dopamine being infused by syringe pumps to maintain blood pressure at 100/50 mm Hg. Prior to a participant entering the simulated ICU, one of the stopcocks for the catecholamine was occluded. Thereafter, the blood pressure of the mannequin dropped to 60/30 mm Hg. If the participant inappropriately released the occlusion, resulting in a catecholamine flush, an operator immediately elevated the blood pressure to 200/100 mm Hg. In the subsequent debriefing session, the simulation facilitator evaluated whether the participant could diagnose that intravenous occlusion was the cause of hypotension in this scenario. RESULTS: Sixteen anesthesiology residents participated in the study. Only 3 of 10 participants who had previous knowledge of how such situations should be handled could appropriately release back pressure. Eleven residents released the occlusion without relieving syringe pressure. After their debriefing sessions, all the participants were of the opinion that the present simulation training was impressive and useful for them. CONCLUSIONS: Anesthesiology residents might inappropriately handle a situation of intravenous occlusion in their clinical practice. It may be necessary for the manufacturers to improve the safety features of syringe pumps.

    DOI： 10.1097/PTS.0000000000000232

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  • Consequences of not relieving negative internal pressure of a medication vial: A survey and simulation study Reviewed

    Hiroko Fujimoto, Tomoya Irie, Hiromasa Kawakami, Tetsuya Miyashita, Takahisa Goto

    JOURNAL OF CLINICAL ANESTHESIA   37   168 - 172   2017.2

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    DOI： 10.1016/j.jclinane.2016.12.002

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  • Roles of protein kinase D in vasoconstriction and hemodynamics Reviewed

    Yoh Sugawara, Yusuke Mizuno, Hiromasa Kawakami, Takahisa Goto

    FASEB JOURNAL   30   2016.4

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  • Influence of Mental Workload on the Performance of Anesthesiologists during Induction of General Anesthesia: A Patient Simulator Study Reviewed

    Hitoshi Sato, Tetsuya Miyashita, Hiromasa Kawakami, Yusuke Nagamine, Shunsuke Takaki, Takahisa Goto

    BIOMED RESEARCH INTERNATIONAL   2016   1058750   2016

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    DOI： 10.1155/2016/1058750

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  • Amount of accidental flush by syringe pump due to inappropriate release of occluded intravenous line

    Hiromasa Kawakami, Tetsuya Miyashita, Ryota Yanaizumi, Takahiro Mihara, Hitoshi Sato, Takayuki Kariya, Yusuke Mizuno, Takahisa Goto

    TECHNOLOGY AND HEALTH CARE   21 ( 6 )   581 - 586   2013

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    DOI： 10.3233/THC-130754

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  • Hypertension and anesthesia Reviewed

    Satoshi Hanada, Hiromasa Kawakami, Takahisa Goto, Shigeho Morita

    CURRENT OPINION IN ANESTHESIOLOGY   19 ( 3 )   315 - 319   2006.6

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    DOI： 10.1097/01.aco.0000192811.56161.23

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  • Inhaled nitric oxide in pediatric cardiac surgery. Reviewed

    Kawakami H, Ichinose F

    International anesthesiology clinics   42 ( 4 )   93 - 100   2004

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MISC

  • Perioperative anesthetic management of patients with cancer using strong opioids: a single-center retrospective observational study

    柳泉亮太, 井上紗緒里, 長嶺祐介, 川上裕理, 佐藤仁, 後藤隆久

    日本麻酔科学会学術集会(Web)   72nd   2025

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  • 肝内胆管癌に対するEx Vivo Surgeryの麻酔管理

    KAWAKAMI TADASHI, KAWAKAMI HIROMASA, SATO HITOSHI, GOTO TAKAHISA

    臨床麻酔(真興交易)   39 ( 11 )   1559 - 1560   2015.11

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    Language：Japanese  

    J-GLOBAL

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  • 手術室での安全対策 7 手術室の災害対策

    SATO HITOSHI, KAWAKAMI HIROMASA, YOKOSE MASASHI, MIYASHITA TETSUYA, KIKUCHI TATSUAKI, GOTO TAKAHISA

    臨床麻酔(真興交易)   38 ( 9 )   1314 - 1322   2014.9

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  • 低流量麻酔の注意点

    KAWAKAMI HIROMASA, GOTO TAKAHISA

    臨床麻酔(真興交易)   38 ( 臨増 )   275 - 285   2014.3

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    Language：Japanese   Publisher：真興交易(株)医書出版部  

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  • 手術室の災害対策 横浜市立大学手術部における手術室災害訓練の経験

    佐藤 仁, 川上 裕理, 刈谷 隆之, 後藤 隆久

    日本臨床麻酔学会誌   33 ( 4 )   539 - 544   2013.7

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    Language：Japanese   Publisher：日本臨床麻酔学会  

    DOI： 10.2199/jjsca.33.539

    CiNii Books

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    Other Link： http://search.jamas.or.jp/link/ui/2013371196

  • 心臓手術の実際 外科医が語る術式,麻酔科医が語る心臓麻酔,臨床工学技士が語る体外循環法 第33回 小児の弁形成,弁置換手術と体外循環法

    益田宗孝, 美濃口和洋, 川上裕理, 大高勝義

    Clin Eng   24 ( 2 )   159 - 168   2013.1

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  • 心臓手術の実際 外科医が語る術式、麻酔科医が語る心臓麻酔、臨床工学技士が語る体外循環法 小児の弁形成、弁置換手術と体外循環法 横浜市立大学附属病院

    益田 宗孝, 美濃口 和洋, 川上 裕理, 大高 勝義

    Clinical Engineering   24 ( 2 )   159 - 168   2013.1

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    Language：Japanese   Publisher：(株)学研メディカル秀潤社  

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  • 手術室の災害対策 横浜市立大学手術部における手術室災害訓練の経験

    佐藤 仁, 川上 裕理, 刈谷 隆之, 後藤 隆久

    日本臨床麻酔学会誌   32 ( 6 )   S144 - S144   2012.10

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  • シミュレーションを利用した麻酔科後期研修医向け講習会の経験

    石山 美保, 中村 京太, 佐藤 仁, 川上 裕理, 後藤 隆久

    神奈川医学会雑誌   36 ( 2 )   315 - 315   2009.7

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  • 私のルーチン 弁疾患

    川上 裕理

    Cardiovascular Anesthesia   13 ( 1 )   101 - 105   2009.5

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    Language：Japanese   Publisher：(一社)日本心臓血管麻酔学会  

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  • 【冠動脈疾患患者の麻酔"Pros & Cons"】 冠動脈疾患患者の麻酔に硬膜外カテーテルを併用すると予後はよくなる? 硬膜外カテーテルと抗凝固の問題 凝固異常患者には血腫のリスクを考え硬膜外麻酔を用いない鎮痛法の選択を

    川上 裕理

    LiSA   15 ( 10 )   1005 - 1007   2008.10

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  • モニタリングをめぐるトラブルとその対処法 中心静脈カテーテル 中心静脈カテーテルを挿入するために、本穿刺針からワイヤーを挿入したが、途中から進みにくくなったため、ワイヤーを抜こうとしたが、抜けなくなった まず、ワイヤーのみでなく金属針もいっしょに抜く

    川上 裕理, 澤 智博

    LiSA   15 ( 3 )   294 - 296   2008.3

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  • 2Dストレイン法によるDor手術後の左室収縮同期性改善効果の検討

    川上裕理, 新見能成, 比企美加, 柿沼玲史, 石黒芳紀, 森田茂穂

    J Anesth   19 ( Supplement (CD-ROM) )   O73.03   2005

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  • Minimum alveolar concentration (MAC) of xenon with sevoflurane in humans

    Yoshinori Nakata, Takahisa Goto, Yoshiki Ishiguro, Katsuo Terui, Hiromasa Kawakami, Masayuki Santo, Yoshinari Niimi, Shigeho Morita

    Anesthesiology   94 ( 4 )   611 - 614   2001

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    Language：English   Publisher：Lippincott Williams and Wilkins  

    DOI： 10.1097/00000542-200104000-00014

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  • Plasma concentration of fentanyl with xenon to block somatic and hemodynamic responses to surgical incision

    Yoshinori Nakata, Takahisa Goto, Hayato Saito, Yoshiki Ishiguro, Katsuo Terui, Hiromasa Kawakami, Yoshihiko Tsuruta, Yoshinari Niimi, Shigeho Morita

    Anesthesiology   92 ( 4 )   1043 - 1048   2000

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    Language：English   Publisher：Lippincott Williams and Wilkins  

    DOI： 10.1097/00000542-200004000-00022

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Presentations

  • 弁疾患

    川上裕理

    Cardiovasc Anesth  2009.5 

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  • 敗血症性ショックに対するPMX施行例の検討

    川上 裕理, 白土 瑞枝, 関口 雅, 内野 滋彦, 藤田 正人, 石井 健, 宇野 幸彦, 福家 伸夫, 森田 茂穂

    日本救急医学会雑誌  1998.9 

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  • 重症拡張型心筋症患者に対する腹腔鏡下手術の2症例

    中島 大介, 増渕 哲仁, 桜井 龍, 宮崎 敦, 川上 裕理, 佐藤 仁, 後藤 隆久

    Cardiovascular Anesthesia  2017.9 

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Research Projects

  • ウエアラブルセンサーによる計測値に基く高齢者転倒リスク予測・予防モデル開発

    Grant number：23K09576  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    佐藤 仁, 後藤 隆久, 中村 京太, 中島 和江, 土屋 慶子, 北村 温美, 安部 猛, 川上 裕理

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • 超音波ガイド下侵襲的処置時の術者負担軽減を目指した安全な超音波画像の提示法の開発

    Grant number：21K10353  2021.4 - 2024.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    川上 裕理, 後藤 隆久, 中村 京太, 佐藤 仁, 小松原 明哲, 安部 猛

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    研究計画どおり、まず、シミュレーターによる計測環境を整備した。視点解析ソフトウエアであるiMotionをPCとともに購入し、シミュレーターを用いて中心静脈を穿刺する際の視点の移動の解析が可能となった。最初の解析の対象として、中心静脈穿刺の経験がほとんどない初期研修医を対象として、パイロットスタディーを実施した。この中で、超音波画像の中心静脈穿刺術野への画像の適切な投影法を、角度や画像の大きさ、プロジェクターでの解像度の設定、超音波機器との接続ケーブルの適正など検討し、実施法を確立した。計測時の台の高さと被験者の身長との関係を確認し、台の高さを適切に設定しなくては、視点解析時に被験者の視点が、測定可能範囲から外れてしまうことが判明したため、台の高さを適切に変更可能な手術台を使用して、身長との関係から適切な高さを設定できるよう測定環境の設定を確立した。また、初期研修医を対象にしたパイロットスタディーにおいて、穿刺の状況を画像に収録し、中心静脈穿刺中の視点解析以外の副次測定項目における定義を確立し、穿刺の成功、穿刺回数、超音波画像の描出の質、合併症の発生についてシミュレーション研究での測定プロトコルを確立した。現在は、初期研修医を対象とした実際のデータを5例収集し、さらにデータ数の集積をおこなっている。また、計画通り対象者を広げ、より中心静脈穿刺に熟練している麻酔科医への測定の準備を始めている。また、実際の臨床でのデータ収集を開始するための準備として、麻酔科医の中で中心静脈穿刺の経験の少ない医師と、経験の豊富な医師の手技をあらためて画像で検討し、プロジェクションマッピングによる穿刺法開発の基礎データを整理している。実際に穿刺針をどのように扱っているのか、どのように超音波画像を利用しているのかを明らかにし、今後の研究を推進する基礎データを収集している。

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  • Role of protein kinase D in vasoconstriction

    Grant number：17K11058  2017.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    MIZUNO Yusuke

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

    Protein kinase D (PKD) is known to be involved in a variety of cellular processes and physiological functions, including cell motility, myocardial contraction, angiogenesis, and smooth muscle contraction, but the role of PKD in vascular function has been unknown. We investigated the role of PKD in systemic circulation and aortic contraction in rats and the exact role of PKD isoforms in human aortic smooth muscle cells (HASMCs). We found that PKD1 may be involved in contraction of the aorta and systemic circulation, and that regulation of vasomotor activity by PKD1 may be associated with phosphorylation of MYPT1. Elucidation of PKD may lead to novel regulation of circulation dynamics.

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  • Exosome of mesenchymal stem cells for the treatment of pulmonary hypertension with microRNA.

    Grant number：17K11059  2017.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    WATANABE Itaru

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

    Mesenchymal stem cells have been reported to be useful in vascular disorders. In our study, monocrotaline-induced pulmonary hypertension rats were intravenously infused with bone marrow-derived and cord blood-derived stem cells and the degree of pulmonary hypertension was observed during the completion phase. No significant reduction in pulmonary hypertension was observed in the rat model with intravenous administration of mesenchymal stem cells of both origins. Although some previous studies have reported improvement in experimental pulmonary hypertension models including monocrotaline-induced hypertension, more detailed investigation of efficacy is needed. In addition to miRNAs, the role of other RNAs, including long non-coding RNAs, in cardiovascular disorders has become increasingly important. It was considered necessary to consider a plan that includes reconsideration of the targets of delivery.

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  • Treatment for PH with VPAC2 agonist vector

    Grant number：26462342  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    MIZUNO Yusuke

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    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    Vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase activating peptide (PACAP) have pulmonary vasodilatory via receptors VPAC1 and VPAC2, which possess a similar affinity for both peptides, and PAC1, a PACAP preferring receptor. We investigated the effects of VPAC1 and VPAC2 selective agonists VIP and PACAP to explore treatment for PH. We examined hemodynamic changes in right ventricular systolic pressure (RVSP), systemic blood pressure (SBP), total pulmonary resistance index (TPRI), total systemic resistance index, and cardiac index (CI) in response to their agonists with monocrotaline (MCT)-induced PH. Activation of VPAC2 receptor with BAY 55&#8211;9837 effectively improved RVSP, TPRI, and CI in MCTinduced PH.

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  • Effect of endogenous NOS inhibitor on pulmonary arterial pressure

    Grant number：25462447  2013.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Shinbori Nobuhiro

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    Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）

    Impairment of endogenous release of nitric oxide (NO), which causes vascular vasodilation and inhibition of smooth muscle cell proliferation, is well known to play a critical role in developing pulmonary hypertension (PH). We explored the mechanism of impared ehdothelial function and eNOS activity in PH using monocrotaline-induced PH rats.
    Increase in PRMT2 and decrease in DDAH1 and DDAH2 in the PH model were associated with increased ADMA contents and consequent impairment of NOS activity. These results may be potentially useful to lower ADMA level for therapeutic benefit.

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  • Role of VPAC2 receptor in monocrotaline-induced pulmonary hypertensionin in rats

    Grant number：25462446  2013.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KAWAKAMI Hiromasa, MIZUNO Yusuke, Miura Norikazu, Watanabe Itaru

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    Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）

    VIP and PACAP have pulmonary vasodilatory and positive inotropic. VIP is a promising option for PH treatment; however, various physiological effects of VIP have limited its clinical use. We investigated the effects of VPAC1 and VPAC2 selective agonists, VIP and PACAP to explore treatment for PH. We examined hemodynamic changes in right ventricular systolic pressure (RVSP), systemic blood pressure (SBP), total pulmonary resistance index (TPRI), total systemic resistance index, and cardiac index (CI) in response to their agonists. In MCT-induced PH, decreased VIP and PACAP were associated with upregulation of VPAC1, VPAC2, and PAC1 in lung tissues. Intravenous injection of VPAC2-selective agonist BAY 55-9837 and VIP, but not [Ala11,22,28]VIP, improved the CI. Activation of VPAC2 receptor with BAY 55-9837 effectively improved RVSP, TPRI, and CI in MCT-induced PH, suggesting a VPAC2 agonist as a possible promising treatment for PH.

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  • Usege of lentiviral vector for treatment of pulmonary hypertension

    Grant number：24592309  2012.4 - 2016.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    WATANABE Itaru, MIZUNO Yusuke, KAWAKAMI Hiromasa, BABA Yasuko

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    Grant amount：\5330000 （ Direct Cost: \4100000 、 Indirect Cost：\1230000 ）

    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional neuropeptide. Although the heart has VIP and PACAP signaling systems including the ligand and receptors, however, involvement of PACAP in cardiac hypertrophy and subsequent heart failure are still unknown. Recently,VIP and PACAP have been reported to have cardioprotective effect and be associated with heart failure.
    In this study, elevated PACAP signaling was associated in hypertrophic right ventricles and heart failure induced with monocrotaline in rats. In addition, intravenous administration of PACAP but not VIP improved cardiac output. Therefore,PACAP may play an important roles in right cardiac hypertrophy. However, further study will be necessary to clarify the role in detail and the mechanism.

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  • calcium sensitization in pulmoary hypertension

    Grant number：23592304  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    MIZUNO Yusuke, KAWAKAMI Hiromasa, WATANABE Itaru, BABA Yasuko

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    Grant amount：\5200000 （ Direct Cost: \4000000 、 Indirect Cost：\1200000 ）

    In this study, we found the involvement of imparied calcium desensitization mechanism of MLCK by phosphorylation of MLCK in pulmoanry hypertension in rats. It is well known that calcium sensitization occured during vascular contraction and in hyper-vasocontractile diseases. However, calcium desensitization mechanism in vasucura diseases is little known. The understanding of the desensitization mechanism may provide novel therapy for pulmonary hypertension.

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  • Involvement of VIP Signaling in Right Cardiac Hypertrophy

    Grant number：21591981  2009 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    WATANABE Itaru, MIZUNO Yusuke, KAWAKAMI Hiromasa

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    Elevated PACAP but not VIP signaling was associated with right ventricular hypertrophy and heart failure induced with monocrotaline in rats. PACAP-preferring receptor PCAl and the common receptor VPAC2 were up-regulated in both ventricles. Thus, PACAP signaling may play a more predominant role during cardiac hypertrophy and hear failure.

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  • Gene therapy for treatment of pulmonary hypertension using plasmid vector

    Grant number：20591810  2008 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    MIZUNO Yusuke, BABA Yasuko, KAWAKAMI Hiromasa

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

    We found decreased expression of neuropeptide VIP, PACAP and decreased expression of their receptors in lung of monocrotaline-induced pulmonary hypertension in rat. It was assumed that the receptor might be induced to compensate for the decrease of VIP and PACAP. Thus, we hypothesized that induction of PACAP in lung could improve pulmonary hypertension. To examine the hypethesis, we created PACAP encoding plasmid and lentivirus vectors and examined the way to introduce them to the lung.

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  • The role of VIP in pulmonary hypertension and application for the gene therapy

    Grant number：20791088  2008 - 2009

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    KAWAKAMI Hiromasa

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    Pulmonary hypertension (PH) is critical disease. It has been reported that neuropeptides VIP, PACAP involve in pulmonary circulation and respiratory system, however, their functions are not fully elucidated. The contents of VIP and PACAP in the lung decreased in experimental PH, while the expression of their receptors VPAC1, VPAC2 and PAC1 increased. Similar results were obtained from cardiac tissue. To verify the hypothesis that replacement of the peptides may improve PH, we constructed plasmid vector encoding VIP or PACAP. We have been investigating the more efficient method to deliver the plasmid and the effect in PH.

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