研究者詳細 - 佐藤渉

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写真a

サトウ　ショウ

佐藤渉

Sho Sato

所属

附属市民総合医療センター消化器病センター講師

プロフィール

これまでに、主に消化器外科治療に15年以上従事し、関連する学会発表・論文執筆を行ってきた。

外部リンク

学位

博士（医学）（横浜市立大学）

研究分野

ライフサイエンス / 消化器外科学

経歴

横浜市立大学附属市民総合医療センター消化器病センター助教

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論文

Prognostic factors of second-line nivolumab monotherapy for unresectable or metastatic esophageal cancer: a multi-institutional cohort study for 184 cases.

Sho Sato, Takashi Suzuki, Takashi Chinen, Hironori Yamaguchi, Yusuke Suzuki, Nobukazu Hokamura, Zenichiro Saze, Koji Kono, Keita Takahashi, Fumiaki Yano, Tsutomu Sato, Takashi Kosaka, Itaru Endo, Yasushi Ichikawa, Yutaka Miyawaki, Hiroshi Sato, Hideaki Shimada

Journal of gastroenterology 2024年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The real-world efficacy, prognostic factors, and adverse events of second-line nivolumab monotherapy and subsequent third-line therapy for unresectable or metastatic esophageal cancer have not been fully evaluated. METHODS: This multi-institutional retrospective cohort study evaluated 184 consecutive patients treated with second-line nivolumab monotherapy for esophageal cancer between March 2021 and December 2022. We assessed tumor response, adverse events, long-term survival, and prognostic factors. RESULTS: Among 128 patients with measurable lesions, the response rate was 23% and the disease control rate for all enrolled patients was 45%. The incidence of grade 3 or higher adverse events was 14%, but no treatment-related deaths presented. Median progression-free survival was 5.1 months and overall survival was 14 months, respectively. C-reactive protein level and performance status were identified as significant prognostic factors of overall survival through Cox proportional hazards analysis. The group with two favorable prognostic factors showed better overall survival than the groups with either one or zero prognostic factors (median overall survival: 22, 15, and 4.4 months, respectively). Among 69 patients who received third-line taxane anticancer agents, the progression-free survival was 6.7 months. CONCLUSIONS: Our study demonstrated that the real-world outcomes of second-line nivolumab monotherapy were comparable to those of previous randomized clinical trials in terms of tumor response, safety, and long-term survival. Furthermore, a good performance status and low C-reactive protein levels may identify patients who are likely to benefit from therapy. Third-line chemotherapy after nivolumab treatment may have an enhanced effect; however, further prospective studies are required to confirm this finding.

DOI： 10.1007/s00535-024-02141-8

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The real-world data of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer: a multi-institutional cohort study.

Sho Sato, Takashi Ssuzuki, Takashi Chinen, Hironori Yamaguchi, Yusuke Suzuki, Nobukazu Hokamura, Zenichiro Saze, Koji Kono, Keita Takahashi, Fumiaki Yano, Chikara Kunisaki, Takashi Kosaka, Itaru Endo, Yasushi Ichikawa, Yutaka Miyawaki, Hiroshi Sato, Hideaki Shimada

International journal of clinical oncology 2024年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The real-world efficacy, feasibility, and prognostic factors of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer are not fully established. METHODS: This multi-institutional retrospective cohort study evaluated 71 consecutive patients treated with immune-checkpoint inhibitor combination therapy for esophageal cancer between March 2021 and December 2022. We assessed tumor response, safety, and long-term survival. RESULTS: In patients with measurable lesions, the response rate was 58%, and the disease control rate for all enrolled patients was 80%. Five patients (7.0%) underwent successful conversion surgery. Grade 3 or higher immune-related adverse events occurred in 13% of patients, and one patient (1.4%) died due to cholangitis. Median progression-free survival was 9.7 (95% confidence interval: 6.5-not reached). C-reactive protein levels and performance status were identified as significant predictors of progression-free survival through Cox proportional hazards analysis. CONCLUSIONS: Immune-checkpoint inhibitor combination therapy for esophageal cancer demonstrated comparable tumor response, safety, and long-term survival to previous randomized clinical trials. Patients with good performance status and low C-reactive protein levels may be suitable candidates for this treatment.

DOI： 10.1007/s10147-024-02532-0

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Ramucirumab Plus Paclitaxel as a Second-line Chemotherapy in Older Adults With Advanced Gastric Cancer (YCOG1601). 国際誌

Sho Sato, Chikara Kunisaki, Yuko Tamura, Akikazu Yago, Kohei Kasahara, Tsutomu Sato, Hiroki Kondo, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

Anticancer research 43 ( 12 ) 5663 - 5670 2023年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND/AIM: Ramucirumab plus paclitaxel has been widely used as a second-line chemotherapy for treating advanced gastric cancer. However, the real-world data of this regimen for older patients with gastric cancer (GC) remains unrevealed. The aim of this study was to clarify the feasibility and efficacy of this regimen for older patients with GC in a single-arm, phase II study. PATIENTS AND METHODS: Patients aged ≥70 years having unresectable or recurrent GC who met the eligible criteria were enrolled. Paclitaxel was administered at a dose of 80 mg/m2 on days 1, 8, and 15, and ramucirumab was administered at a dose of 8 mg/kg on day 1 and day 15 of a 4-week cycle. Primary endpoint was the incidence of adverse events and secondary endpoints were response rate, progression-free survival, and overall survival. A total of 25 patients were enrolled in the full-set analysis. RESULTS: Grade 3 or more adverse events were observed in 21 patients (84.0%). Neutropenia was most frequently observed (68.0%), followed by peripheral sensory neuropathy (12.0%), and febrile neutropenia (12.0%). Median progression-free survival and overall survival were 6.9 months and 13.4 months, respectively. Disease control rate was 88.0%, and response rate of patients with measurable lesions was 52.9%. Notably, no treatment-related deaths occurred. CONCLUSION: Ramucirumab plus paclitaxel as a second-line chemotherapy demonstrated acceptable oncological outcomes, despite the occurrence of frequent adverse events. It is necessary to carefully select patients and adjust treatment regimens in older patients with GC to safely administer chemotherapy and subsequently achieve satisfactory long-term outcomes.

DOI： 10.21873/anticanres.16771

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Long-term Outcomes of Neoadjuvant Chemotherapy With Docetaxel, Cisplatin and S-1 for Stage III Gastric Cancer. 国際誌

Kohei Kasahara, Chikara Kunisaki, Sho Sato, Hiroki Kondo, Masazumi Takahashi, Yuko Tamura, Nobuhiro Tsuchiya, Yusaku Tanaka, Kei Sato, Jun Kimura, Takashi Kosaka, Hidetaka Ono, Hirochika Makino, Hirotoshi Akiyama, Itaru Endo

Anticancer research 43 ( 6 ) 2841 - 2850 2023年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND/AIM: In the previous phase I/II study, we established neoadjuvant chemotherapy (NAC) using bi-weekly docetaxel, cisplatin, and S-1 (DCS) for clinical stage III gastric cancer. This study aimed to clarify long-term outcomes of this treatment. PATIENTS AND METHODS: Relapse-free survival (RFS) and overall survival (OS) were calculated by the Kaplan-Meier method and prognostic factors for RFS and OS were identified by univariate analysis. RESULTS: A total of 47 patients with clinical stage III gastric cancer were enrolled in this study. The 5-year RFS and OS rates were 69.8% and 74.3%, respectively, in all registered patients. Moreover, the 5-year OS and RFS rates in patients receiving R0 gastrectomy were 68.0% and 79.4%, respectively. Neutrophil-lymphocyte ratio (NLR) before NAC ≥2.41, prognostic nutritional index (PNI) before NAC ≤50.4, Glasgow prognostic score before NAC classification 2, NLR after NAC ≥1.43, PNI after NAC <48.0, and Grade 1a/1b pathological response significantly worsened RFS. NLR after NAC ≥1.43, PNI before NAC ≤50.4, NLR after NAC ≥1.43, and body weight loss >5 kg after NAC significantly worsened OS. CONCLUSION: Although bi-weekly DCS therapy as neoadjuvant setting showed acceptable long-term outcomes, poor immune-nutritional status before and after NAC caused worse long-term survival in stage III gastric cancer patients. It is warranted to conduct a well-designed prospective randomized control study to compare long-term outcomes using the bi-weekly DCS regimen between patients with and without immune-nutritional support during peri-NAC.

DOI： 10.21873/anticanres.16453

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Solitary living worsens the continuation of adjuvant chemotherapy for gastric cancer. 国際誌

Shinsuke Nagasawa, Tsutomu Sato, Junya Morita, Hiroki Kondo, Nobuhiro Tsuchiya, Sho Sato, Kazuhisa Takeda, Toru Aoyama, Norio Yukawa, Yasushi Rino, Chikara Kunisaki

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 49 ( 2 ) 368 - 375 2023年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: No studies have reported the effect of solitary living on adjuvant chemotherapy continuation in patients with gastric cancer. This study aimed to investigate the influence of solitary living on the efficacy of adjuvant chemotherapy after curative gastrectomy. METHODS: We enrolled 155 patients with pathological stage II/III gastric cancer who underwent gastrectomy and adjuvant chemotherapy between January 2013 and March 2020. The patients were divided into two groups according to their living conditions, the solitary group (n = 34) versus the non-solitary group (n = 121). Clinicopathological features, predictive factors for the continuation of adjuvant chemotherapy, and long-term survival were compared between the two groups. RESULTS: The median body weight loss (BWL) at one month after surgery (8.9% vs. 7.0%, p = 0.01), and the rates of failure to continue six courses of chemotherapy were higher in the solitary group (41.2% vs. 14.9%, p = 0.002) than in the non-solitary group. Multivariate analysis revealed that solitary living was an independent predictive factor for discontinuing adjuvant chemotherapy (odds ratio 3.36, 95% confidence interval [CI; 1.32-8.58], p = 0.01) as well as 10% BWL at one month after surgery (odds ratio 3.99, 95% CI [1.57-10.2], p = 0.004). The relapse-free survival was significantly worse in the solitary group (p = 0.03). CONCLUSIONS: Solitary living may be an independent risk factor for discontinuation of adjuvant chemotherapy in patients with gastric cancer. It is necessary to examine whether social and medical support organized by medical institutes and the government improves the continuation of adjuvant chemotherapy in patients living alone.

DOI： 10.1016/j.ejso.2022.09.003

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残胃癌に対する至適リンパ節郭清範囲は? 幽門側胃切除後残胃癌に対する至適リンパ節郭清の検討

佐藤渉, 國崎主税, 松下直彦, 小倉巧也, 森田順也, 近藤裕樹, 井口健太, 前澤幸男, 笠原康平, 沼田正勝, 熊本宜文, 佐藤勉, 武田和永, 田村裕子, 小坂隆司, 秋山浩利, 遠藤格

日本胃癌学会総会記事 95回 191 - 191 2023年2月

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記述言語：日本語出版者・発行元：(一社)日本胃癌学会

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Endoscopic Resection with One-Port Placement: A Newly Developed Technique for the Safe Management of Advanced Endoscopic Resection for Gastric Gastrointestinal Stromal Tumors. 国際誌

Atsushi Sawada, Kingo Hirasawa, Chiko Sato, Sho Sato, Tsutomu Sato, Kazuya Sugimori, Chikara Kunisaki, Shin Maeda

Digestion 104 ( 6 ) 460 - 467 2023年

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記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: Endoscopic full-thickness resection (EFTR) without laparoscopic assistance (pure EFTR) is an emerging, less invasive treatment for gastrointestinal stromal tumors (GISTs). However, the technique has seldom been performed outside China because of concerns regarding pneumoperitoneum, maintenance of endoscopic view, and endoscopic suturing. This study aimed to evaluate the efficacy and safety of endoscopic resection with one-port placement (EROPP) for gastric GISTs. METHODS: This retrospective study included 17 patients with gastric GISTs originating from the muscularis propria who underwent EROPP between 2019 and 2022. One camera port was inserted in the umbilicus before initiating the endoscopic procedure to maintain intra-abdominal pressure, which was monitored and adjusted via this port. While allowing for conversion to laparoscopic surgery if needed, EFTR was performed as follows: (1) circumferential incision of the mucosal and submucosal layers around the lesion was performed by typical endoscopic submucosal dissection; (2) an intentional perforation and subsequent seromuscular resection was made using dental floss and an endo-clip for traction; and (3) closure of the gastric full-thickness defect was performed with an over-the-scope clip (OTSC) after peroral retrieval of the specimen. We retrospectively assessed the short-term outcomes and safety. RESULTS: All procedures were completed successfully without conversion to laparoscopic surgery. The median size of the resected tumors was 23 mm (range, 8-35 mm), the median resection time was 36 min (range, 22-95 min), and closure time was 18 min (range, 10-45 min). The rates of en bloc and complete resection were 100% and 88%, respectively. In 2 cases, another port was added to aspirate the leaking fluid or check the condition of the endoscopic closure. All gastric defects were endoscopically closed, mainly using OTSCs. The recovery course for all patients was uneventful, and no adverse events were reported. CONCLUSIONS: EROPP is a safe and minimally invasive treatment for gastric GISTs and appears to be suitable for introducing EFTR procedures.

DOI： 10.1159/000532012

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Is Prophylactic Splenectomy Necessary for Proximal Advanced Gastric Cancer Invading the Greater Curvature with Clinically Negative Splenic Hilar Lymph Node Metastasis? A Multi-Institutional Cohort Study (YCOG2003) 査読

Sho Sato, Chikara Kunisaki, Hiroki Kondo, Nobuhiro Tsuchiya, Yusaku Tanaka, Masazumi Takahashi, Kei Sato, Jun Kimura, Hidetaka A. Ono, Hirochika Makino, Yuko Tamura, Kohei Kasahara, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

Annals of Surgical Oncology 29 ( 9 ) 5885 - 5891 2022年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

DOI： 10.1245/s10434-022-11939-w

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その他リンク： https://link.springer.com/article/10.1245/s10434-022-11939-w/fulltext.html
CRMP4 Up-regulates M2 Macrophages and Myeloid-derived Suppressor Cells to Promote Pancreatic Cancer in Mice. 国際誌

Yuzo Minegishi, Yukihiko Hiroshima, Keiichi Yazawa, Sho Sato, Yasuhiro Yabushita, Yuki Homma, Ryusei Matsuyama, Ikuma Kato, Yoshio Goshima, Itaru Endo

Anticancer research 42 ( 2 ) 791 - 799 2022年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND/AIM: We previously observed higher prevalence of high-grade pancreatic intraepithelial neoplasia (PanIN) in LSL-KrasG12D/+; Pdx1Cre/+ (KC-Crmp4wild) mice than LSL-KrasG12D/+; Pdx1Cre/+; Crmp4-/- (KC-Crmp4-/-) mice. This study investigated the relationship between collapsin response mediator protein 4 (CRMP4) and immune cell infiltration in pancreatic cancer. MATERIALS AND METHODS: PanIN was induced by intraperitoneal injection of caerulein into KC-Crmp4wild and KC-Crmp4-/- mice, and immune cells in PanIN lesions were compared. Subcutaneous tumors were created by injecting Pan02 cells, and tumor diameter was compared between Crmp4wild and Crmp4-/- mice every 7 days. Peritumoral immune cells were examined immunohisto chemically. RESULTS: High-grade PanIN in KC mice showed statistically significantly high expression of CD163 (p=0.031) and CD11b (p=0.027). Following subcutaneous injection of Pan02 cells, tumor diameter was greater in Crmp4wild mice than Crmp4-/- mice. Crmp4wild mice exhibited higher CD163 and CD11b expression than Crmp4-/- mice in tumors (p<0.001). CONCLUSION: CRMP4 might promote pancreatic cancer by up-regulating M2 macrophages and myeloid-derived suppressor cells.

DOI： 10.21873/anticanres.15537

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The new prognostic score for unresectable or recurrent gastric cancer treated with nivolumab: A multi-institutional cohort study.

Sho Sato, Yoko Oshima, Yu Matsumoto, Yasuyuki Seto, Hiroharu Yamashita, Koichi Hayano, Masayuki Kano, Hidetaka Andrew Ono, Norio Mitsumori, Muneharu Fujisaki, Chikara Kunisaki, Hirotoshi Akiyama, Itaru Endo, Yasushi Ichikawa, Hidejiro Urakami, Hirokazu Kubo, Sakae Nagaoka, Hideaki Shimada

Annals of gastroenterological surgery 5 ( 6 ) 794 - 803 2021年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Background: Real-world outcomes of nivolumab treatment for gastric cancer and associated prognostic factors remain unclear; the present study aimed to evaluate both items. Methods: A total of 278 consecutive patients treated with nivolumab for gastric cancer during 2017-2019 were enrolled in this multi-institutional retrospective cohort study. The impact of laboratory findings, immune-related adverse events (irAEs), and clinicopathological factors on long-term survival was evaluated using the Cox proportional hazards model. Results: The response rate was 11.7% in patients with measurable lesions. The overall and progression-free survival estimates were 6.77 and 2.53 months, respectively. The incidence of irAEs was 30.6% (6.8% for grade ≥3). There were no treatment-related deaths. Multivariate analysis revealed that C-reactive protein level of ≤0.5 mg/dL (hazard ratio = 0.476, P < .001), irAE occurrence (hazard ratio = 0.544, P < .001), albumin level of >3.5 g/dL (hazard ratio = 0.688, P = .045), performance status 0 (hazard ratio = 0.711, P = .028), lymphocyte count >1000/μL (hazard ratio = 0.686, P = .027), and differentiated histological type (hazard ratio = 0.740, P = .046) were independently associated with improved survival. The median survival of patients with four or more good prognostic factors was 18.3 months. Conclusion: Nivolumab showed safety and survival benefits in patients with previously treated unresectable or recurrent gastric cancer. Low C-reactive protein level, irAE occurrence, high albumin level, high lymphocyte count, and differentiated histological type may affect outcomes. The presence of four or more good prognostic factors may help identify likely long-term survivors.

DOI： 10.1002/ags3.12489

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Prognostic impact of dimensional factors in pT1 gastric cancer. 国際誌

Chikara Kunisaki, Masazumi Takahashi, Sho Sato, Nobuhiro Tsuchiya, Jun Watanabe, Tsutomu Sato, Kazuhisa Takeda, Yusaku Tanaka, Kohei Kasahara, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

Surgical oncology 38 101584 - 101584 2021年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The significance of the dimensional factors (tumor diameter, area and volume) as the prognostic factor has not been precisely evaluated in pT1 gastric cancer. OBJECTIVES: This study aimed to identify the clinical impact and to confirm the clinical feasibility of the dimensional factors as prognostic factors in pT1 gastric cancer. METHODS: We analyzed prognostic factors for disease-specific survival (DSS), overall survival (OS) using clinicopathological factors by univariate and multivariate analyses and the pattern of recurrence in 2011 pT1 gastric cancer (mucosal and submucosal cancers) undergoing R0 gastrectomy. The cut-off values of each dimensional factor was decided by the ROC curve. RESULTS: Cox proportional hazard regression model showed that older age (≥75) and more advanced pN stage were adverse independent prognostic factors for DSS, and revealed that older age (≥75), greater preoperative co-morbid diseases, proximal and total gastrectomy, operative method and Clavien-Dindo classification (≥grade III) were independent adverse factors for OS. Any dimensional factors were not independent prognostic factors for any survival. CONCLUSIONS: The dimensional factors do not influence both OS and DSS in pT1 gastric cancer patients and so it is difficult to apply these dimensional factors for conducting therapeutic strategies.

DOI： 10.1016/j.suronc.2021.101584

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Feasibility of esophagectomy for esophageal cancer in elderly patients: a case-control study. 国際誌

Nobuhiro Tsuchiya, Chikara Kunisaki, Sho Sato, Yusaku Tanaka, Kei Sato, Jun Watanabe, Kazuhisa Takeda, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

Langenbeck's archives of surgery 2021年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: Surgery in elderly patients with esophageal cancer is challenging due to high mortality and limited survival. This study aimed to evaluate the safety and effectiveness of curative esophagectomy in elderly patients with esophageal cancer. METHODS: This study included 77 and 112 patients with esophageal cancer aged ≥ 70 and 40-64 years, respectively, who underwent R0 esophagectomy between January 1998 and December 2016. Patient characteristics, intraoperative outcomes, postoperative complications, and long-term survival were compared. RESULTS: The proportions of comorbid diseases (85.7% vs. 57.1%; P < 0.001), the American Society of Anesthesiologists score (1/2/3; 2.6%/94.8%/2.6% vs. 42.9%/57.1%/0%; P < 0.001), the preoperative systemic inflammation score (SIS) (0/1/2; 20.8%/48.1%/31.2% vs. 38.4%/38.4%/23.2%; P = 0.036), and postoperative complications (Clavien-Dindo grade ≥ III) (33.8% vs. 20.5%; P = 0.041) were significantly higher in the elderly group than those in the non-elderly group. However, long-term overall survival (OS) and relapse-free survival were not significantly different between the groups. On multivariate analysis, SIS (hazard ratio, 3.06; P = 0.037) and severe postoperative complications (hazard ratio, 2.01; P = 0.039) were significantly correlated with OS in the elderly group. CONCLUSIONS: As SIS and severe postoperative complications lead to poor prognosis after R0 esophagectomy in elderly patients, selecting appropriate patients for esophagectomy and preventing severe postoperative complications is essential.

DOI： 10.1007/s00423-021-02271-0

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High postoperative neutrophil-lymphocyte ratio and low preoperative lymphocyte-monocyte ratio predict poor prognosis in gastric cancer patients receiving gastrectomy with positive lavage cytology: a retrospective cohort study. 国際誌

Sho Sato, Chikara Kunisaki, Masazumi Takahashi, Hirokazu Kubo, Nobuhiro Tsuchiya, Kei Sato, Hiroshi Miyamoto, Yuko Tamura, Hiroki Kondo, Yusaku Tanaka, Kohei Kasahara, Takashi Kosaka, Hirotoshi Akiyama, Yusuke Saigusa, Itaru Endo

Langenbeck's archives of surgery 2021年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Long-term outcomes in gastric cancer patients with positive lavage cytology (CY1) are generally poor. This multi-institutional retrospective cohort study aims to evaluate the clinical significance of the neutrophil-lymphocyte ratio (NLR) and the lymphocyte-monocyte ratio (LMR) in CY1 gastric cancer patients. METHODS: A total of 121 CY1 gastric cancer patients without other non-curative factors, who underwent macroscopically curative resection, were enrolled in this study. The cutoff values of preoperative NLR (pre-NLR), postoperative NLR (post-NLR), preoperative LMR (pre-LMR), and postoperative LMR (post-LMR) were defined by the Contal and O'Quigley method as 2.3, 3.0, 2.5, and 3.2, respectively. A Cox proportional hazard model was used to identify the independent prognostic factors among NLR, LMR, and other clinicopathological factors. RESULTS: There were significant differences in the overall survival (OS) between the two groups: high post-NLR groups vs. low post-NLR group (median survival time, months) (10.9 vs. 22.8, P = 0.006) and high pre-LMR group vs. low pre-LMR group (21.3 vs. 11.0, P = 0.001). The LMR value elevated significantly after gastrectomy (P = 0.020), although not in the NLR value (P = 0.733). On multivariate analysis, high post-NLR (hazard ratio = 1.506; 95% confidence interval = 1.047-2.167; P = 0.027), low pre-LMR (1.773; 1.135-2.769, 0.012), and no postoperative chemotherapy (1.558; 1.053-2.305, 0.027) were found to be independent prognostic factors for adverse OS. CONCLUSIONS: Because a combination of high post-NLR and low pre-LMR may be an adverse prognostic marker in resectable CY1 gastric cancer patients, it is necessary to conduct a prospective trial to confirm a useful perioperative chemotherapeutic regimen for these patients.

DOI： 10.1007/s00423-021-02233-6

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Psoas muscle depletion during preoperative chemotherapy for advanced gastric cancer has a negative impact on long-term outcomes after gastrectomy. 国際誌

Nobutoshi Horii, Takashi Kosaka, Ryo Fujiwara, Sho Sato, Hirotoshi Akiyama, Chikara Kunisaki, Itaru Endo

Asia-Pacific journal of clinical oncology 2021年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）

AIM: The significance of sarcopenia in cancers has been widely recognized. However, few studies have focused on chronological changes in sarcopenia in cancer patients. This study aimed to clarify the clinical significance of changes in the psoas muscle area before and after preoperative chemotherapy. METHODS: This study included 39 patients who underwent gastrectomy followed by preoperative chemotherapy for advanced gastric cancer between January 2010 and December 2016 in our hospital. The psoas muscle area was measured at the umbilical level before and after chemotherapy, and the relationship between its chronological changes and the long-term prognosis was examined. RESULTS: Patients were classified into two groups according to changes in the psoas muscle area before and after preoperative chemotherapy: remarkable muscle depletion and normal groups. No significant differences were observed in clinicopathological factors. Notably, the remarkable muscle depletion group included significantly more male patients (P = .018) and showed a high weight loss rate (P < .001). Although no significant difference was observed in the recurrence-free survival between the two groups (P = .484), overall survival was significantly worse in the remarkable muscle depletion group (P < .001). Multivariate analysis for prognosis revealed that pathological stage III or higher (P = .022) and decreased psoas muscle area (P = .038) were independent prognostic factors. CONCLUSIONS: The present findings suggest that psoas muscle depletion during preoperative chemotherapy is a prognostic factor for poor long-term outcomes in patients who underwent gastrectomy followed by preoperative chemotherapy for advanced gastric cancer.

DOI： 10.1111/ajco.13514

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Comparison of Converse Ω Anastomosis and Extracorporeal Anastomosis After Laparoscopic Distal Gastrectomy for Gastric Cancer. 国際誌

Nobuhiro Tsuchiya, Chikara Kunisaki, Hirokazu Kubo, Sho Sato, Yusaku Tanaka, Kei Sato, Hiroshi Miyamoto, Jun Watanabe, Kazuhisa Takeda, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo, Toshihiro Misumi

Surgical laparoscopy, endoscopy & percutaneous techniques 31 ( 4 ) 485 - 491 2021年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Converse Ω anastomosis is a recently developed technique of delta-shaped anastomosis for intracorporeal gastroduodenostomy to simplify the anastomotic procedures and reduce their potential risks. This study aimed to evaluate the safety and effectiveness of converse Ω anastomosis, comparing it with conventional extracorporeal Billroth-I anastomosis after laparoscopic distal gastrectomy (LDG) for gastric cancer. PATIENTS AND METHODS: Among 169 gastric cancer patients who underwent LDG with Billroth-I anastomosis anastomosis between April 2013 and March 2018, we selected 100 patients by propensity score matching (50 in the converse Ω anastomosis group and 50 in the extracorporeal anastomosis group). Patients' characteristics, intraoperative outcomes, postoperative complications, and survival time were compared between the 2 groups. RESULTS: Median anastomosis time was significantly longer in the converse Ω group than in the extracorporeal group (40.0 vs. 30.5 min, P=0.005). However, the total procedure time did not differ significantly between the groups. Intraoperative blood loss volume was significantly lower in the converse Ω group than in the extracorporeal anastomosis group (40 vs. 120 mL, P<0.001). There were no significant differences in the number of dissected lymph nodes, postoperative morbidity, mortality, or length of hospital stay. The postoperative body mass index and the prognostic nutritional index did not differ between the groups 1 year after surgery. There were no significant differences in overall survival and relapse-free survival between the 2 groups. CONCLUSIONS: Converse Ω anastomosis is feasible and safe. This novel technique can be adopted as a treatment option for reconstruction after LDG in patients with early-stage gastric cancer. Therefore, the risks and benefits of converse Ω anastomosis after LDG should be confirmed in larger cohorts.

DOI： 10.1097/SLE.0000000000000906

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Feasibility of totally laparoscopic total gastrectomy in obese patients with gastric cancer

Hideaki Suematsu, Chikara Kunisaki, Hiroshi Miyamato, Kei Sato, Sho Sato, Yusaku Tanaka, Norio Yukawa, Yasushi Rino, Takashi Kosaka, Itaru Endo, Munetaka Masuda

Langenbeck's Archives of Surgery 2021年

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記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media Deutschland GmbH

DOI： 10.1007/s00423-021-02369-5

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A Case of Gastrointestinal Stromal Tumor with a Tumor Embolus in the Portal Vein

Kohei Kasahara, Takashi Kosaka, Sho Sato, Yusaku Tanaka, Hiroshi Miyamoto, Kei Sato, Atsushi Ishibe, Hirotoshi Akiyama, Chikara Kunisaki, Naoko Udaka, Satoshi Fujii, Itaru Endo

Japanese Journal of Gastroenterological Surgery 54 ( 8 ) 505 - 513 2021年

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記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Society of Gastroenterological Surgery

DOI： 10.5833/jjgs.2020.0105

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Real-World Therapeutic Outcomes of S-1 Adjuvant Chemotherapy for pStage II/III Gastric Cancer in the Elderly. 国際誌

Chikara Kunisaki, Sho Sato, Nobuhiro Tsuchiya, Hirokazu Kubo, Jun Watanabe, Tsutomu Sato, Kazuhisa Takeda, Yuko Tamura, Kohei Kasahara, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 62 ( 1 ) 40 - 52 2021年

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The predictive factors for discontinuation of S-1 administration and prognostic factors in elderly patients with pStage II/III gastric cancer receiving S-1 adjuvant chemotherapy remain unclear. METHODS: Between January 2004 and December 2016, 80 elderly gastric cancer patients (≥70 years) undergoing curative D2 gastrectomy were enrolled in this study. Predictive factors for completion of S-1 administration over 1 year, adverse events due to S-1 administration, and prognostic factors for overall survival (OS) and relapse-free survival (RFS) were evaluated. RESULTS: Twenty-eight patients (35%) completed 8 courses of S-1. The median relative dose intensity was 82.1% (IQR 31.1-100%). The incidence rates of hematological and nonhematological adverse events were acceptable. Distal gastrectomy was an independent predictive factor for completion of S-1 administration (odds ratio [OR] 0.364; 95% confidence interval [CI] 0.141-0.939; p = 0.037). Higher postoperative neutrophil count/lymphocyte count (N/L) ratio and more advanced stage adversely influenced OS. Multivariate analysis revealed that a higher postoperative N/L ratio and more advanced stage adversely affected RFS. CONCLUSION: To complete adjuvant S-1 administration to elderly patients with pStage II/III gastric cancer, total gastrectomy should be avoided if possible. A new regimen for elderly gastric cancer patients with higher postoperative N/L ratios and more advanced stage should be established.

DOI： 10.1159/000515175

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大動脈食道瘻に対して有茎空腸を用いたダブルトラクト再建を二期的に施行した1例

佐藤渉, 國崎主税, 小坂隆司, 秋山浩利, 土屋伸広, 佐藤圭, 湯川ひろお, 根本寛子, 内田敬二, 遠藤格

日本食道学会学術集会プログラム・抄録集 74回 412 - 412 2020年12月

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記述言語：日本語出版者・発行元：(NPO)日本食道学会

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A two-stage reconstruction for aortoesophageal fistula after replacement of thoracic aorta for Stanford Type B dissecting aortic aneurysm: esophagectomy and a double-tract reconstruction using the pedicled jejunum: a case report and literature review.

Sho Sato, Chikara Kunisaki, Yusaku Tanaka, Kei Sato, Hiroshi Miyamoto, Norio Yukawa, Hiroko Nemoto, Keiji Uchida, Teppei Nishii, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

Clinical journal of gastroenterology 13 ( 5 ) 722 - 727 2020年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）

An aortoesophageal fistula (AEF) is a rare, potentially fatal condition, and esophagectomy is usually performed simultaneously with aortic surgery. However, esophageal reconstruction method has not been established. This case report describes a two-stage operation for AEF after replacement of thoracic aorta for Stanford Type B dissecting aortic aneurysm. A 61-year-old man who had underwent total arch replacement with frozen elephant trunk for Stanford Type B dissecting aortic aneurysm 3 years ago admitted to the hospital with high fever. Based on the computed tomography and endoscopic findings, he was diagnosed with having aortoesophageal fistula (AEF). After administration of antibiotics with fasting foods and drinks for a month, he underwent the second aortic replacement, thoracic esophagectomy, cervical esophagostomy, gastrostomy and omental wrapping. After 3 months, he underwent double-tract reconstruction using the pedicled jejunal transfer with supercharge and superdrainage via the subcutaneous route. After reconstruction surgery, the patient was doing well. Two-stage reconstruction was a safe procedure for AEF case who underwent aortic replacement, esophagectomy and omental wrapping. The pedicled jejunum reconstruction via subcutaneous route is an optional procedure for second reconstruction surgery.

DOI： 10.1007/s12328-020-01158-9

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Laparoscopic total gastrectomy for gastric cancer in elderly patients

Hideaki Suematsu, Chikara Kunisaki, Hiroshi Miyamato, Kei Sato, Sho Sato, Yusaku Tanaka, Norio Yukawa, Yasushi Rino, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo, Munetaka Masuda

In Vivo 34 ( 5 ) 2933 - 2939 2020年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Institute of Anticancer Research

DOI： 10.21873/invivo.12123

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神奈川県下の高齢者胃癌症例に対する腹腔鏡下胃切除術の現状

佐藤渉, 國崎主税, 高橋正純, 大島貴, 比企直樹, 大坪毅人, 小澤壯治, 遠藤格

日本内視鏡外科学会雑誌 25 ( 4 ) 254 - 262 2020年7月

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記述言語：日本語出版者・発行元：(一社)日本内視鏡外科学会

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[Effectiveness of L-Carnitine in the Treatment of Fatigue Associated with Chemotherapy in Patients with Gastric Cancer].

Hayato Watanabe, Chikara Kunisaki, Yusaku Tanaka, Sho Sato, Kei Sato, Hiroshi Miyamoto, Norio Yukawa, Ryuji Kosaka, Hirotoshi Akiyama, Munetaka Masuda, Itaru Endo

Gan to kagaku ryoho. Cancer & chemotherapy 47 ( 3 ) 490 - 492 2020年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）

AIM: Low serum carnitine levels have been reported in patients with cancer receiving chemotherapy and are considered one of the factors causing fatigue associated with chemotherapy. We evaluated the effectiveness of L-carnitine in the treatment of fatigue associated with chemotherapy in patients with gastric cancer(GC). MATERIALS AND METHODS: We performed a randomized controlled trial between December 2013 and December 2018. Untreated patients with advanced GC were included in the study; 1 patient developed an allergy after receiving the first chemotherapy and was excluded from the study. The primary endpoint was brief fatigue inventory(BFI). Patients were categorized into 2 groups: those who received L-carnitine oral supplements(group C)and those who did not receive L-carnitine oral supplements(group N). RESULTS: The serum carnitine levels were improved significantly in group C compared with group N. BFIwas more aggravated in group N than group C; however, the difference was not significant. CONCLUSION: We could not demonstrate the effectiveness of L-carnitine in the treatment of fatigue associated with chemotherapy in patients with GC.

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Efficacy of Video-assisted Thoracoscopic Esophagectomy for Stage II/III Esophageal Cancer: Analysis Using the Propensity Scoring System. 国際誌

Kenta Iguchi, Chikara Kunisaki, Sho Sato, Yusaku Tanaka, Hiroshi Miyamoto, Takashi Kosaka, Kei Sato, Hirotoshi Akiyama, Itaru Endo, Norio Yukawa, Yasushi Rino, Munetaka Masuda, Takeharu Yamanaka

Anticancer research 40 ( 3 ) 1587 - 1595 2020年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND/AIM: The purpose of this study was to evaluate the usefulness of minimally invasive esophagectomy (MIE) for stage II/III esophageal cancer (EC). PATIENTS AND METHODS: We compared surgical outcomes between MIE and open esohagectomy in EC patients with pStage II/III using the propensity scoring system. RESULTS: Fifty-seven patients were classified into the MIE group and 57 patients into the open esophagectomy (OE) group. The incidence of major complications was similar between the two groups. The 5-year OS was significantly better in the MIE group (69.0% vs. 35.5%; p=0.004) and no significant difference was observed in the 5-year recurrence-free survival (RFS, 52.2% vs. 29.2%; p=0.064). Multivariate analysis showed MIE was a prognostic factor of OS (p<0.001) and RFS (p=0.032). CONCLUSION: MIE was as safe and feasible as OE, and an independent prognostic factor for OS and RFS in patients with stage II/III EC.

DOI： 10.21873/anticanres.14106

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Low Incidence of High-Grade Pancreatic Intraepithelial Neoplasia Lesions in a Crmp4 Gene-Deficient Mouse Model of Pancreatic Cancer. 査読国際誌

Keiichi Yazawa, Fumio Nakamura, Daiki Masukawa, Sho Sato, Yukihiko Hiroshima, Yasuhiro Yabushita, Ryutaro Mori, Ryusei Matsuyama, Ikuma Kato, Hideki Taniguchi, Yoshio Goshima, Itaru Endo

Translational oncology 13 ( 3 ) 100746 - 100746 2020年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Pancreatic intraepithelial neoplasia (PanIN), the most common premalignant lesion of the pancreas, is a histologically well-defined precursor to invasive pancreatic ductal adenocarcinoma (PDAC). However, the molecular mechanisms underlying the progression of PanINs have not been fully elucidated. Previously, we demonstrated that the expression of collapsin response mediator protein 4 (CRMP4) in PDAC was associated with poor prognosis. The expression of CRMP4 was also augmented in a pancreatitis mouse model. However, the role of CRMP4 in the progression of PanIN lesions remains uncertain. In the present study, we examined the relationship between CRMP4 expression and progression of PanIN lesions using genetically engineered mouse models. PanIN lesions were induced by peritoneal injection of the cholecystokinin analog caerulein in LSL-KRASG12D; Pdx1-Cre (KC-Crmp4 wild-type, WT) mice and LSL-KRASG12D; Pdx1-Cre; Crmp4-/- (KC-Crmp4 knockout, KO) mice. We analyzed pancreatic tissue sections from these mice and evaluated PanIN grade by hematoxylin and eosin staining. CRMP4 expression was examined and the cellular components assessed by immunohistochemistry using antibodies against CRMP4, CD3, and α-smooth muscle actin (SMA). The incidence of high-grade PanIN in KC-Crmp4 WT mice was higher than that in KC-Crmp4 KO animals. CRMP4 was expressed not only in epithelial cells but also in αSMA-positive cells in stromal areas of PanIN lesions. The CRMP4 expression in stromal areas correlated with PanIN grade in WT mice. These results suggested that the expression of CRMP4 in stromal cells may underlie the incidence or progression of PanIN.

DOI： 10.1016/j.tranon.2020.100746

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Systemic Review and Meta-analysis of Impact of Splenectomy for Advanced Gastric Cancer

CHIKARA KUNISAKI, SHO SATO, NOBUHIRO TSUCHIYA, JUN WATANABE, TSUTOMU SATO, KAZUHISA TAKEDA, KOHEI KASAHARA, TAKASHI KOSAKA, HIROTOSHI AKIYAMA, ITARU ENDO, TOSHIHIRO MISUMI

In Vivo 34 ( 6 ) 3115 - 3125 2020年

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掲載種別：研究論文（学術雑誌）出版者・発行元：Anticancer Research USA Inc.

DOI： 10.21873/invivo.12145

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A Case with a Huge Retroperitoneal Abscess with Duodenal Ulcer Penetration Treated with Percutaneous Drainage

Kei Kawashima, Sho Sato, Atsushi Ishibe, Takashi Kosaka, Nobuhiro Tsuchiya, Kei Sato, Hiroshi Miyamoto, Chikara Kunisaki, Hirotoshi Akiyama, Itaru Endo

Japanese Journal of Gastroenterological Surgery 53 ( 12 ) 960 - 967 2020年

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記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Society of Gastroenterological Surgery

DOI： 10.5833/JJGS.2019.0158

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Curative-Intent Surgery for Stage IV Advanced Gastric Cancer: Who Can Undergo Surgery and What Are the Prognostic Factors for Long-Term Survival? 査読国際誌

Sho Sato, Chikara Kunisaki, Yusaku Tanaka, Kei Sato, Hiroshi Miyamoto, Norio Yukawa, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo, Toshihiro Misumi

Annals of surgical oncology 26 ( 13 ) 4452 - 4463 2019年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: A retrospective study was performed to evaluate the predictive factors for performing curative-intent surgery and prognostic factors for long-term survival of patients undergoing surgery for stage IV gastric cancer. PATIENTS AND METHODS: Between 2001 and 2017, 271 patients with stage IV gastric cancer with distant metastasis who underwent systemic chemotherapy were enrolled. Logistic regression analysis was performed to evaluate predictive factors for curative-intent surgery. Cox proportional hazards regression model was applied for patients who were subsequently treated with curative-intent surgery to identify prognostic factors for long-term survival. RESULTS: Curative-intent surgery was performed in 48 patients (17.7%). Median survival time was significantly longer in the surgery group than in the nonsurgery group (53 vs. 11 months, p < 0.0001). R0 resection was performed in 35 patients (72.9%). The three-year overall survival (OS) rates of the R0, R1, and R2 surgery groups were 75.4%, 33.3%, and 25.0%, respectively (p = 0.0002). Logistic regression analysis revealed that lymphogenous distant metastasis alone (odds ratio = 3.276, p = 0.004), positive lavage cytology alone (6.394, 0.014), doublet or triplet chemotherapy (4.064, 0.034), and high Glasgow prognostic score (0.276, 0.001) were independent predictive factors for performing curative-intent surgery. Among patients undergoing surgery, the Cox proportional hazards regression model for OS showed that R0 surgery was an independent prognostic factor for favorable OS (hazard ratio 0.188, p = 0.022). CONCLUSIONS: Patients with lymphogenous distant metastasis alone, P0CY1 alone, good immunonutritional status, and doublet/triplet chemotherapy are candidates for performing effective curative-intent surgery. R0 surgery is crucial for improving long-term survival after surgery.

DOI： 10.1245/s10434-019-07790-1

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Beppu's Nomogram Score Is an Independent Prognostic Factor for Colorectal Liver Metastasis Receiving Perioperative Chemotherapy and/or Targeted Therapy. 査読国際誌

Higuchi A, Aoyama T, Kazama K, Murakawa M, Atsumi Y, Katayama Y, Numata K, Sawazaki S, Numata M, Sato S, Sugano N, Tamagawa H, Mushiake H, Oshima T, Yukawa N, Morinaga S, Rino Y, Masuda M, Shiozawa M

In vivo (Athens, Greece) 33 ( 4 ) 1301 - 1306 2019年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.21873/invivo.11603

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Tumor Volume Index as a Prognostic Factor in Patients after Curative Esophageal Cancer Resection. 査読国際誌

Miyamoto H, Kunisaki C, Sato S, Tanaka Y, Sato K, Kosaka T, Yukawa N, Akiyama H, Saigusa Y, Endo I

Annals of surgical oncology 26 ( 6 ) 1909 - 1915 2019年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1245/s10434-019-07308-9

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Outcomes of preoperative S-1 and docetaxel combination chemotherapy in patients with locally advanced gastric cancer. 査読国際誌

Kosaka T, Akiyama H, Miyamoto H, Sato S, Tanaka Y, Sato K, Kunisaki C, Endo I

Cancer chemotherapy and pharmacology 83 ( 6 ) 1047 - 1055 2019年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s00280-019-03813-6

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A Phase II Study of Tri-weekly Low-dose Nab-paclitaxel Chemotherapy for Patients with Advanced Gastric Cancer 査読国際誌

Sato S

Anticancer Research 38 ( 12 ) 6911 - 6917 2018年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.21873/anticanres.13068

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Surgical Outcomes of Reduced-Port Laparoscopic Gastrectomy Versus Conventional Laparoscopic Gastrectomy for Gastric Cancer: A Propensity-Matched Retrospective Cohort Study. 査読国際誌

Chikara Kunisaki, Hiroshi Miyamoto, Sho Sato, Yusaku Tanaka, Kei Sato, Yusuke Izumisawa, Norio Yukawa, Takashi Kosaka, Hirotoshi Akiyama, Yusuke Saigusa, Kentaro Sakamaki, Takeharu Yamanaka, Itaru Endo

Annals of surgical oncology 25 ( 12 ) 3604 - 3612 2018年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1245/s10434-018-6733-x

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A Phase I/II Study of NAC with Docetaxel, Cisplatin, and S-1 for Stage III Gastric Cancer. 査読国際誌

Tanaka Y, Kunisaki C, Izumisawa Y, Makino H, Kimura J, Sato S, Miyamoto H, Kosaka T, Ono HA, Takahashi M, Sato K, Akiyama H, Endo I

Anticancer research 38 ( 10 ) 6015 - 6021 2018年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.21873/anticanres.12951

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Impact of sarcopenia in patients with unresectable locally advanced esophageal cancer receiving chemoradiotherapy 査読

Sho Sato, Chikara Kunisaki, Hideaki Suematsu, Yusaku Tanaka, Hiroshi Miyamoto, Takashi Kosaka, Norio Yukawa, Kuniya Tanaka, Kei Sato, Hirotoshi Akiyama, Itaru Endo

In Vivo 32 ( 3 ) 603 - 610 2018年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Institute of Anticancer Research

DOI： 10.21873/invivo.11282

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Feasibility of Laparoscopy-assisted Gastrectomy for Gastric Cancer in Elderly Patients: A Case-Control Study. 査読国際誌

Nobuhiro Tsuchiya, Chikara Kunisaki, Hirochika Makino, Jun Kimura, Ryo Takagawa, Sho Sato, Yusaku Tanaka, Kei Sato, Hiroshi Miyamoto, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo, Kentaro Sakamaki, Takeharu Yamanaka

Surgical laparoscopy, endoscopy & percutaneous techniques 28 ( 2 ) 102 - 107 2018年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: The present study evaluated the safety and effectiveness of laparoscopic gastrectomy (LG) in elderly gastric cancer patients. PATIENTS AND METHODS: This study included 78 gastric cancer patients aged 80 years or above [39 in the LG group and 39 in the open gastrectomy group (matched)]. Patient characteristics, surgical outcomes, survival time, and immunonutritional status were compared. RESULTS: Mean blood loss was significantly lower in the LG group, although the operation time did not differ. There were no significant differences in the number of dissected lymph nodes, postoperative morbidity, mortality, total hospital stay, and the causes of death. The prognostic nutritional index and skeletal muscle index at 1 year were better maintained in the LG group than in the open gastrectomy group. The overall and relapse-free survivals did not differ. CONCLUSIONS: LG may be feasible in elderly patients with gastric cancer. A prospective randomized controlled trial should be conducted to confirm its efficacy.

DOI： 10.1097/SLE.0000000000000520

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当院における70歳以上高齢者食道癌症例に対する治療の現状

湯川寛夫, 小坂隆司, 宮本洋, 佐藤渉, 田中優作, 末松秀明, 佐藤勉, 虫明寛行, 青山徹, 大島貴, 田中邦哉, 利野靖, 遠藤格, 益田宗孝, 國崎主税

日本外科学会定期学術集会抄録集 118回 2329 - 2329 2018年4月

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記述言語：日本語出版者・発行元：(一社)日本外科学会

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Evaluation of optimal lymph node dissection in remnant gastric cancer based on initial distal gastrectomy 査読国際誌

Kenta Iguchi, Chikara Kunisaki, Sho Sato, Yusaku Tanaka, Hiroshi Miyamoto, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo, Yasushi Rino, Munetaka Masuda

Anticancer Research 38 ( 3 ) 1677 - 1683 2018年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Institute of Anticancer Research

DOI： 10.21873/anticanres.12401

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Multicenter phase II study of capecitabine plus cisplatin as first-line therapy for human epidermal growth factor receptor 2-negative advanced gastric cancer: Yokohama Clinical Oncology Group Study YCOG1107 査読国際誌

Kei Sato, Chikara Kunisaki, Takashi Kosaka, Ryo Takagawa, Masazumi Takahashi, Yusuke Izumisawa, Hiroshi Miyamoto, Sho Sato, Yusaku Tanaka, Naotaka Yamaguchi, Jun Kimura, Hidetaka A. Ono, Hirochika Makino, Hirotoshi Akiyama, Itaru Endo

CANCER CHEMOTHERAPY AND PHARMACOLOGY 80 ( 5 ) 939 - 943 2017年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s00280-017-3430-6

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高齢者(75歳以上)食道癌症例における治療因子の検討

湯川寛夫, 小坂隆司, 宮本洋, 佐藤渉, 田中優作, 末松秀明, 虫明寛行, 青山徹, 佐藤勉, 大島貴, 田中邦哉, 吉川貴己, 利野靖, 遠藤格, 益田宗孝, 國崎主税

日本消化器外科学会雑誌 50 ( Suppl.2 ) 179 - 179 2017年10月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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A Comparative Study of Intravenous Injection Form and Oral Jelly Form of Alendronate Sodium Hydrate for Bone Mineral Disorder after Gastrectomy 査読国際誌

Chikara Kunisaki, Yusaku Tanaka, Takashi Kosaka, Hiroshi Miyamoto, Sho Sato, Hideaki Suematsu, Norio Yukawa, Kei Sato, Yusuke Izumisawa, Hirotoshi Akiyama, Masataka Taguri, Takeharu Yamanaka, Itaru Endo

DIGESTION 95 ( 2 ) 162 - 171 2017年

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1159/000458755

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胸腔内で結腸穿孔をきたした食道癌術後横隔膜ヘルニア嵌頓の1例査読

山本淳, 長嶺弘太郎, 佐藤渉, 杉浦浩朗, 亀田久仁郎, 竹川義則, 久保章

日本臨床外科学会雑誌 77 ( 11 ) 2701 - 2705 2016年11月

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記述言語：日本語出版者・発行元：日本臨床外科学会

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直腸癌術後に吻合部口側腸管の広範な索状狭窄を生じた1例

佐藤渉, 亀田久仁郎, 鈴木伸吾, 山本淳, 三宅益代, 長嶺弘太郎, 久保章, 秋山浩利, 遠藤格

横浜医学 67 ( 2 ) 75 - 78 2016年8月

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記述言語：日本語出版者・発行元：横浜市立大学医学会

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J01499&link_issn=&doc_id=20161208380001&doc_link_id=http%3A%2F%2Fid.nii.ac.jp%2F1246%2F00000503%2F&url=http%3A%2F%2Fid.nii.ac.jp%2F1246%2F00000503%2F&type=%89%A1%95l%8Es%97%A7%91%E5%8Aw%81F%89%A1%95l%8Es%97%A7%91%E5%8Aw%8Aw%8Fp%8B%40%8A%D6%83%8A%83%7C%83W%83g%83%8A&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80205_3.gif
Caerulein-induced pancreatitis augments the expression and phosphorylation of collapsin response mediator protein 4 査読

Sho Sato, Fumio Nakamura, Yukihiko Hiroshima, Yoji Nagashima, Ikuma Kato, Naoya Yamashita, Yoshio Goshima, Itaru Endo

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES 23 ( 7 ) 422 - 431 2016年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1002/jhbp.361

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幽門側胃切除術後の重度縫合不全に対して経鼻的ドレナージが奏功した1例査読

三宅益代, 杉浦浩朗, 鈴木伸吾, 山本淳, 佐藤渉, 長嶺弘太郎, 亀田久仁郎, 久保章

日本腹部救急医学会雑誌 36 ( 2 ) 395 - 395 2016年2月

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記述言語：日本語出版者・発行元：(一社)日本腹部救急医学会

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A case of long-distance stenosis of oral anastomosed colon after rectal resection

Sho Sato, Kunio Kameda, Shingo Suzuki, Masuyo Miyake, Jun Yamamoto, Koutaro Nagamine, Akira Kubo, Hirotoshi Akiyama, Itaru Endo

Yokohama Medical Journal 67 ( 2 ) 75 - 78 2016年

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記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Medical Association of Yokohama City University

Scopus

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Hepatic Resection for Hepatocellular Carcinoma in the Elderly: Selecting Hepatectomy Procedures Based on Patient Age 査読国際誌

Sho Sato, Kuniya Tanaka, Kazunori Nojiri, Takafumi Kumamoto, Ryutaro Mori, Kouichi Taniguchi, Ryusei Matsuyama, Kazuhisa Takeda, Michio Ueda, Hirotoshi Akiyama, Masataka Taguri, Itaru Endo

ANTICANCER RESEARCH 35 ( 12 ) 6855 - 6860 2015年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Web of Science

PubMed

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Curative fluorescence-guided surgery of pancreatic cancer in combination with UVC irradiation in orthotopic mouse models 査読

Hiroshima Yukihiko, Maawy Ali, Zhang Yong, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

CANCER RESEARCH 75 2015年8月

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DOI： 10.1158/1538-7445.AM2015-5123

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The expression level of CRMP4 and its phosphorylated form are augmented in caerulein-induced acute or chronic pancreatitis 査読

Sato Sho, Nakamura Fumio, Hiroshima Yukihiko, Endo Itaru, Goshima Yoshio

JOURNAL OF PHARMACOLOGICAL SCIENCES 128 ( 3 ) S174 2015年7月

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Randomized clinical trial of peritoneal lavage for preventing surgical site infection in elective liver surgery 査読

Kuniya Tanaka, Kenichi Matsuo, Daisuke Kawaguchi, Takashi Murakami, Yukihiko Hiroshima, Atsushi Hirano, Sho Sato, Itaru Endo, Masataka Taguri, Keiji Koda

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES 22 ( 6 ) 446 - 453 2015年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1002/jhbp.222

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PubMed

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The advantages of patient derived orthotopic xenograft (PDOX) of cervical cancer compared to the PDX model 査読

Hiroshima Yukihiko, Zhang Yong, Maawy Ali, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

CLINICAL & EXPERIMENTAL METASTASIS 32 ( 3 ) 208 2015年3月

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The combination of Salmonella typhimurium A1-R and anti-VEGF therapy inhibits patient-derived orthotopic xenograft (PDOX) pancreatic cancer 査読

Hiroshima Yukihiko, Zhao Ming, Katz Matthew H. G, Fleming Jason B, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Zhang Yong, Maawy Ali, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

CLINICAL & EXPERIMENTAL METASTASIS 32 ( 3 ) 207 - 208 2015年3月

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Fluorescence-guided surgery and neoadjuvant chemotherapy on a pancreatic cancer patient derived orthotopic xenograft (PDOX) 査読

Hiroshima Yukihiko, Maawy Ali, Zhang Yong, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

CLINICAL & EXPERIMENTAL METASTASIS 32 ( 3 ) 208 2015年3月

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The first patient derived orthotopic xenograft (PDOX) model of patient cervical cancer 査読

Hiroshima Yukihiko, Zhang Yong, Maawy Ali, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

CLINICAL & EXPERIMENTAL METASTASIS 32 ( 3 ) 208 - 209 2015年3月

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Targeting tumor-educated macrophages by zoledronic acid inhibits proliferation and metastasis of human pancreatic cancer in nude mice 査読

Hiroshima Yukihiko, Hassenein Mohamed Kadry, Menen Rhiana, Katz Matthew H. G, Fleming Jason B, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Maawy Ali, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

CLINICAL & EXPERIMENTAL METASTASIS 32 ( 3 ) 209 2015年3月

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Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell-line mouse models 査読国際誌

Yukihiko Hiroshima, Yong Zhang, Takashi Murakami, Ali Maawy, Shinji Miwa, Mako Yamamoto, Shuya Yano, Sho Sato, Masashi Momiyama, Ryutaro Mori, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Yasushi Ichikawa, Michael Bouvet, Itaru Endo, Ming Zhao, Robert M. Hoffman

ONCOTARGET 5 ( 23 ) 12346 - 12357 2014年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.18632/oncotarget.2641

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PubMed

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A portable imaging system for fluorescence-guided surgery on a human colon cancer patient-derived orthotopic xenograft (PDOX (TM)) nude mouse model 査読

Hiroshima Yukihiko, Maawy Ali, Kaushal Sharmeela, Zhang Yong, Uehara Fuminari, Miwa Shinji, Yano Shuya, Sato Sho, Murakami Takashi, Momiyama Masashi, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

MOLECULAR CANCER RESEARCH 12 2014年11月

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DOI： 10.1158/1557-3125.MODORG-B01

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UVC irradiation in combination with fluorescence-guided surgery cures metastatic human pancreatic cancer in orthotopic mouse models 査読

Hiroshima Yukihiko, Maawy Ali, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

CANCER RESEARCH 74 ( 19 ) 2014年10月

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DOI： 10.1158/1538-7445.AM2014-4375

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Establishment of a patient-derived orthotopic xenograft (PDOX) model of patient cervical cancer 査読

Hiroshima Yukihiko, Zhang Yong, Maawy Ali, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Chishima Takashi, Tanaka Kuniya, Maawy Ali, Endo Itaru, Hoffman Robert M

CANCER RESEARCH 74 ( 19 ) 2014年10月

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DOI： 10.1158/1538-7445.AM2014-1204

Web of Science

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Efficacy of Salmonella typhimurium A1-R and anti-VEGF therapy on a patient-derived orthotopic xenograft (PDOX) pancreatic cancer model 査読

Hiroshima Yukihiko, Zhao Ming, Katz Matthew H. G, Fleming Jason B, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Zhang Yong, Maawy Ali, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

CANCER RESEARCH 74 ( 19 ) 2014年10月

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DOI： 10.1158/1538-7445.AM2014-1230

Web of Science

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The advantages of patient-derived orthotopic xenograft (PDOX) of metastatic cervical cancer for individualized therapy compared to the PDX model 査読

Hiroshima Yukihiko, Zhang Yong, Maawy Ali, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

CANCER RESEARCH 74 ( 19 ) 2014年10月

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DOI： 10.1158/1538-7445.AM2014-1229

Web of Science

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Zoledronic acid inhibits proliferation and metastasis of human pancreatic cancer in the patient-derived orthotopic xenograft (PDOX) model by targeting tumor-educated macrophages 査読

Hiroshima Yukihiko, Hassenein Mohamed K, Menen Rhiana, Katz Matthew H. G, Fleming Jason B, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Maawy Ali, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

CANCER RESEARCH 74 ( 19 ) 2014年10月

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DOI： 10.1158/1538-7445.AM2014-3130

Web of Science

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Efficacy of neoadjuvant chemotherapy in combination with fluorescence-guided surgery on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) 査読

Hiroshima Yukihiko, Maawy Ali, Zhang Yong, Sato Sho, Murakami Takashi, Yamamoto Mako, Uehara Fuminari, Miwa Shinji, Yano Shuya, Momiyama Masashi, Chishima Takashi, Tanaka Kuniya, Bouvet Michael, Endo Itaru, Hoffman Robert M

CANCER RESEARCH 74 ( 19 ) 2014年10月

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DOI： 10.1158/1538-7445.AM2014-3486

Web of Science

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Fluorescence-Guided Surgery in Combination with UVC Irradiation Cures Metastatic Human Pancreatic Cancer in Orthotopic Mouse Models 査読国際誌

Yukihiko Hiroshima, Ali Maawy, Yong Zhang, Sho Sato, Takashi Murakami, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman

PLOS ONE 9 ( 6 ) e99977 2014年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1371/journal.pone.0099977

Web of Science

PubMed

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Successful Fluorescence-Guided Surgery on Human Colon Cancer Patient-Derived Orthotopic Xenograft Mouse Models Using a Fluorophore-Conjugated Anti-CEA Antibody and a Portable Imaging System 査読国際誌

Yukihiko Hiroshima, Ali Maawy, Cristina A. Metildi, Yong Zhang, Fuminari Uehara, Shinji Miwa, Shuya Yano, Sho Sato, Takashi Murakami, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman

JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES 24 ( 4 ) 241 - 247 2014年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1089/lap.2013.0418

Web of Science

PubMed

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Hand-held high-resolution fluorescence imaging system for fluorescence-guided surgery of patient and cell-line pancreatic tumors growing orthotopically in nude mice 査読国際誌

Yukihiko Hiroshima, Ali Maawy, Sho Sato, Takashi Murakami, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman

JOURNAL OF SURGICAL RESEARCH 187 ( 2 ) 510 - 517 2014年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.jss.2013.11.1083

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PubMed

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大腸憩室炎緊急手術症例における術後合併症のリスク因子の検討査読

和田朋子, 山岸茂, 樅山将士, 原田真吾, 佐藤渉, 松尾憲一, 仲野明

日本大腸肛門病学会雑誌 67 ( 3 ) 145 - 150 2014年3月

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記述言語：日本語出版者・発行元：The Japan Society of Coloproctology

目的:大腸憩室症の緊急手術における合併症発生の危険因子を検討し,適切な術式を考察する.方法:大腸憩室症穿孔,または難治性大腸憩室炎の診断で手術を施行した33例についてClavian-Dindo分類3以上の合併症発生群10例と非発生群23例に分けて検討した.結果:単変量解析では合併症発生群で有意にHinchey分類3以上,出血が多く,ICU在室期間が長かった.多変量解析ではHinchey分類3以上が独立危険因子として抽出された(HR9.199,95%CI 1.030-82.133,p=0.047).Hinchey分類3以上の14症例に関し検討をすると,多変量解析で血清alb<3.0が独立危険因子として抽出された.結論:Hinchey分類3以上の憩室炎に対する手術は合併症発生頻度が高い.特に血清alb<3.0の患者では,過大侵襲を避けた術式を選択し,厳重な術後管理が必要であると考えられた.(著者抄録)

DOI： 10.3862/jcoloproctology.67.145

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その他リンク： http://search.jamas.or.jp/link/ui/2014126376
Laparoscopy-assisted colectomy versus open colectomy for colorectal cancer in Fujisawa City Hospital

Atsushi Ishibe, Shigeru Yamagishi, Kanechika Den, Nobuhiro Tsutiya, Sho Sato, Yusaku Tanaka, Kenichi Matsuo, Kouichirou Misuta, Akira Nakano

Yokohama Medical Journal 63 ( 2 ) 95 - 99 2012年

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記述言語：日本語掲載種別：研究論文（学術雑誌）

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MISC

腹腔鏡手術を施行した小腸憩室穿孔の一例

藤原大樹, 石部敦士, 鈴木紳祐, 佐藤渉, 小澤真由美, 小坂隆司, 秋山浩利, 加藤生真, 遠藤格

日本臨床外科学会雑誌 80 ( 10 ) 1949 - 1949 2019年10月

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記述言語：日本語出版者・発行元：日本臨床外科学会

J-GLOBAL

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CRMP4は膵上皮内腫瘍性病変(PanIN)の進行を促進させる

矢澤慶一, 中村史雄, 佐藤渉, 廣島幸彦, 加藤生真, 五嶋良郎, 遠藤格

日本消化器外科学会総会 74回 P250 - 7 2019年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

J-GLOBAL

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術中上部消化管内視鏡を併用したZenker憩室の1手術例

足立祥子, 松尾憲一, 本庄優衣, 高橋直行, 春田浩一, 佐藤渉, 泉澤祐介, 樅山将士, 山岸茂, 山崎安信, 仲野明

神奈川医学会雑誌 43 ( 1 ) 50 - 51 2016年1月

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記述言語：日本語出版者・発行元：神奈川県医師会

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悪性線維性組織球腫の小腸転移による腸重積の一例

浅野友美, 樅山将士, 山岸茂, 足立祥子, 本庄優衣, 和田朋子, 春田浩一, 佐藤渉, 泉澤祐介, 松尾憲一, 仲野明

神奈川医学会雑誌 42 ( 2 ) 257 - 257 2015年7月

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記述言語：日本語出版者・発行元：神奈川県医師会

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転倒を機転とした鼠径ヘルニア嚢内小腸穿孔の一例

高橋弘毅, 樅山将士, 山岸茂, 足立祥子, 本庄優衣, 和田朋子, 春田浩一, 佐藤渉, 泉澤祐介, 松尾憲一, 仲野明

神奈川医学会雑誌 42 ( 2 ) 251 - 251 2015年7月

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記述言語：日本語出版者・発行元：神奈川県医師会

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術前診断が困難であった潜在的Linitis plastica型胃癌の1例

佐藤渉, 山岸茂, 田鐘寛, 土屋伸広, 春田浩一, 田中優作, 石部敦士, 松尾憲一, 簾田康一郎, 仲野明

神奈川医学会雑誌 42 ( 1 ) 47 - 47 2015年1月

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記述言語：日本語出版者・発行元：神奈川県医師会

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Tumor-targeting Salmonella typhimurium A1-R enhances gemcitabine bevacizumab efficacy on a patient-derived orthotopic xenograft (PDOX) pancreatic cancer nude mouse model

Y. Hiroshima, M. Zhao, M. H. G. Katz, J. B. Fleming, S. Sato, T. Murakami, M. Yamamoto, F. Uehara, S. Miwa, S. Yano, M. Momiyama, Y. Zhang, A. Maawy, T. Chishima, K. Tanaka, M. Bouvet, I. Endo, R. M. Hoffman

EUROPEAN JOURNAL OF CANCER 50 121 - 121 2014年11月

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記述言語：英語掲載種別：研究発表ペーパー・要旨（国際会議）

Web of Science

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肝切除術におけるリスク評価と治療成績向上に向けた対策肝切除術の安全性向上を目指した肝予備能評価と周術期管理

田中邦哉, 松尾憲一, 村上崇, 藪下泰宏, 佐藤渉, 熊本宜文, 平野敦史, 山崎将人, 遠藤格, 幸田圭史

日本消化器外科学会総会 69回 PD - 5 2014年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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小腸脂肪腫を誘引として腸重積症を発症した一例

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神奈川医学会雑誌 41 ( 2 ) 208 - 209 2014年7月

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記述言語：日本語出版者・発行元：神奈川県医師会

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日本肝胆膵外科学会・学術集会プログラム・抄録集 26回 546 - 546 2014年6月

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記述言語：日本語出版者・発行元：(一社)日本肝胆膵外科学会

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OP-105-3 肝切除術時における閉腹時腹腔内洗浄のSSIに及ぼす影響(OP-105 肝その他,一般演題,第114回日本外科学会定期学術集会)

佐藤渉, 田中邦哉, 野尻和典, 熊本宜文, 森隆太郎, 谷口浩一, 松山隆生, 武田和永, 秋山浩利, 遠藤格

日本外科学会雑誌 115 ( 2 ) 500 - 500 2014年3月

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記述言語：日本語出版者・発行元：一般社団法人日本外科学会

CiNii Books

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当院における残胃癌症例の治療成績

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日本消化器外科学会総会 68回 RS - 46 2013年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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佐藤渉, 山岸茂, 足立祥子, 本庄優衣, 和田朋子, 高橋直行, 泉澤祐介, 樅山将士, 松尾憲一, 仲野明

日本消化器外科学会総会 68回 O - 8 2013年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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直腸癌に対する局所切除術の治療成績

本庄優衣, 山岸茂, 足立祥子, 高橋直行, 和田朋子, 佐藤渉, 泉澤祐介, 樅山将士, 松尾憲一, 仲野明

日本消化器外科学会総会 68回 P - 67 2013年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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当院における膵管内乳頭粘液性腫瘍(IPMN)手術症例の検討

松尾憲一, 仲野明, 本庄優衣, 春田浩一, 高橋直行, 和田朋子, 佐藤渉, 泉澤祐介, 樅山将士, 山岸茂

日本消化器外科学会総会 68回 P - 112 2013年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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大腸癌同時性腹膜播種症例の予後規定因子からみた治療戦略

山岸茂, 樅山将士, 足立祥子, 本庄優衣, 和田朋子, 高橋直行, 佐藤渉, 泉澤祐介, 松尾憲一, 仲野明

日本消化器外科学会総会 68回 O - 76 2013年7月

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大腸憩室症による緊急手術症例の検討

和田朋子, 山岸茂, 樅山将士, 足立祥子, 本庄優衣, 高橋直行, 佐藤渉, 泉澤祐介, 松尾憲一, 仲野明

日本消化器外科学会総会 68回 P - 98 2013年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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大腸癌イレウス症例における腸管減圧の意義

樅山将士, 山岸茂, 足立祥子, 本庄優衣, 高橋直行, 和田朋子, 佐藤渉, 泉澤祐介, 松尾憲一, 仲野明

日本消化器外科学会総会 68回 RS - 43 2013年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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大腸憩室穿孔症例の検討

和田朋子, 山岸茂, 足立祥子, 本庄優衣, 高橋直行, 春田浩一, 佐藤渉, 泉澤祐介, 樅山将士, 松尾憲一, 仲野明

日本外科学会雑誌 114 ( 臨増2 ) 1037 - 1037 2013年3月

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当院における外傷性脾損傷の検討

春田浩一, 松尾憲一, 足立祥子, 本庄優衣, 高橋直行, 和田朋子, 佐藤渉, 泉澤祐介, 樅山将士, 山岸茂, 仲野明

日本外科学会雑誌 114 ( 臨増2 ) 815 - 815 2013年3月

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大腸癌腹膜播種症例の予後規定因子の検討

山岸茂, 樅山将士, 本庄優衣, 春田浩一, 高橋直行, 和田朋子, 佐藤渉, 泉澤祐介, 松尾憲一, 仲野明

日本外科学会雑誌 114 ( 臨増2 ) 616 - 616 2013年3月

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絞扼性イレウスの診断における判別式の有用性についての検討

本庄優衣, 山岸茂, 足立祥子, 春田浩一, 和田朋子, 佐藤渉, 泉澤祐介, 樅山将士, 松尾憲一, 仲野明

日本腹部救急医学会雑誌 33 ( 2 ) 365 - 365 2013年2月

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記述言語：日本語出版者・発行元：(一社)日本腹部救急医学会

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当院における大腸癌卵巣転移手術症例の腹膜播種分類における妥当性の検討

石部敦士, 山岸茂, 田鍾寛, 土屋伸広, 春田浩一, 佐藤渉, 田中優作, 松尾憲一, 簾田康一郎, 仲野明

日本大腸こう門病学会雑誌 66 ( 2 ) 143 - 143 2013年2月

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記述言語：日本語出版者・発行元：(一社)日本大腸肛門病学会

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下部消化管穿孔による急性汎発性腹膜炎症例におけるNPWTの有用性

佐藤渉, 仲野明, 本庄優衣, 樅山将士, 山岸茂, 松尾憲一, 内藤亜由美

創傷(Web) 4 ( 2 ) 96-101 (J-STAGE) 2013年

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記述言語：日本語

DOI： 10.11310/jsswc.4.96

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高度呼吸機能障害症例に対する腹腔鏡下大腸癌手術の検討

山岸茂, 樅山将士, 佐藤渉, 松尾憲一, 仲野明

日本内視鏡外科学会雑誌 17 ( 7 ) 712 - 712 2012年12月

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当院における腹腔鏡下大腸切除症例の検討

樅山将士, 山岸茂, 佐藤渉, 松尾憲一, 仲野明

日本内視鏡外科学会雑誌 17 ( 7 ) 709 - 709 2012年12月

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チーム医療で実践するNPWTを用いた下部消化管穿孔術後創管理の効果

内藤亜由美, 佐藤渉, 松尾憲一, 山岸茂, 籾山将士, 和田朋子, 春田浩一, 本庄優衣, 根岸美津江, 仲野明

日本創傷治癒学会プログラム・抄録集 42nd 92 - 92 2012年12月

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記述言語：日本語出版者・発行元：(一社)日本創傷治癒学会

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再発閉鎖孔ヘルニアに対してKugel Patchを用いて修復した1例

佐藤渉, 山岸茂, 春田浩一, 石部敦士, 松尾憲一, 仲野明

日本腹部救急医学会雑誌 32 ( 7 ) 1263-1266 (J-STAGE) - 1266 2012年11月

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記述言語：日本語出版者・発行元：(一社)日本腹部救急医学会

DOI： 10.11231/jaem.32.1263

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高齢者に対する化学療法の現状

樅山将士, 山岸茂, 足立祥子, 本庄優衣, 春田浩一, 和田朋子, 佐藤渉, 泉澤祐介, 松尾憲一, 仲野明

日本臨床外科学会雑誌 73 ( 増刊 ) 999 - 999 2012年10月

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記述言語：日本語出版者・発行元：日本臨床外科学会

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胃十二指腸潰瘍穿孔に対する手術適応判断におけるCTスコアリングの有用性

春田浩一, 松尾憲一, 足立祥子, 本庄優衣, 高橋直行, 和田朋子, 佐藤渉, 泉澤祐介, 樅山将士, 山岸茂, 仲野明

日本臨床外科学会雑誌 73 ( 増刊 ) 600 - 600 2012年10月

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記述言語：日本語出版者・発行元：日本臨床外科学会

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下部消化管穿孔による急性汎発性腹膜炎症例におけるNPWTの有用性

佐藤渉, 山岸茂, 足立祥子, 本庄優衣, 春田浩一, 和田朋子, 泉澤祐介, 樅山将士, 松尾憲一, 仲野明, 内藤亜由美

日本臨床外科学会雑誌 73 ( 増刊 ) 489 - 489 2012年10月

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記述言語：日本語出版者・発行元：日本臨床外科学会

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腹腔鏡下前方切除術における視野展開とJ型腸管クランプ鉗子を用いた腸管洗浄切離の工夫

山岸茂, 樅山将士, 足立祥子, 本庄優衣, 和田朋子, 春田浩一, 佐藤渉, 泉澤祐介, 松尾憲一, 仲野明

日本臨床外科学会雑誌 73 ( 増刊 ) 644 - 644 2012年10月

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記述言語：日本語出版者・発行元：日本臨床外科学会

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食道炎による食道気管支瘻の1例

山本淳, 山岸茂, 足立祥子, 本庄優衣, 和田朋子, 春田浩一, 佐藤渉, 泉澤祐介, 樅山将士, 松尾憲一, 吉本昇, 仲野明

日本臨床外科学会雑誌 73 ( 増刊 ) 810 - 810 2012年10月

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記述言語：日本語出版者・発行元：日本臨床外科学会

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大腸憩室症による穿孔症例の検討

和田朋子, 山岸茂, 足立祥子, 本庄優衣, 春田浩一, 佐藤渉, 高橋直行, 泉澤祐介, 樅山将士, 松尾憲一, 仲野明

日本臨床外科学会雑誌 73 ( 増刊 ) 537 - 537 2012年10月

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記述言語：日本語出版者・発行元：日本臨床外科学会

DOI： 10.3919/jjsa.73.537

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当院における大腸癌術後SSIの検討

足立祥子, 山岸茂, 本庄優衣, 和田朋子, 春田浩一, 高橋直行, 佐藤渉, 泉澤祐介, 樅山将士, 松尾憲一, 仲野明

日本臨床外科学会雑誌 73 ( 増刊 ) 568 - 568 2012年10月

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記述言語：日本語出版者・発行元：日本臨床外科学会

DOI： 10.3919/jjsa.73.568

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腹腔鏡下直腸癌手術におけるJ型腸管クランプ鉗子を用いた腸管洗浄切離法

山岸茂, 樅山将士, 和田朋子, 佐藤渉, 松尾憲一, 仲野明

日本大腸こう門病学会雑誌 65 ( 9 ) 611 - 611 2012年9月

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記述言語：日本語出版者・発行元：(一社)日本大腸肛門病学会

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当院における大腸憩室症に対する手術症例の検討

和田朋子, 山岸茂, 佐藤渉, 樅山将士, 松尾憲一, 仲野明

日本大腸こう門病学会雑誌 65 ( 9 ) 688 - 688 2012年9月

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記述言語：日本語出版者・発行元：(一社)日本大腸肛門病学会

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大腸癌イレウス症例におけるイレウスチューブによる腸管減圧の意義

佐藤渉, 山岸茂, 和田朋子, 樅山将士, 松尾憲一, 仲野明

日本大腸こう門病学会雑誌 65 ( 9 ) 581 - 581 2012年9月

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記述言語：日本語出版者・発行元：(一社)日本大腸肛門病学会

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高齢者に対する腹腔鏡下大腸癌手術における妥当性の検討

樅山将士, 山岸茂, 和田朋子, 佐藤渉, 松尾憲一, 仲野明

日本大腸こう門病学会雑誌 65 ( 9 ) 572 - 572 2012年9月

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記述言語：日本語出版者・発行元：(一社)日本大腸肛門病学会

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当院における進行再発大腸癌に対するUGT1A1*28/*6遺伝子多型と塩酸イリノテカンの副作用に関する検討

土屋伸広, 山岸茂, 佐藤渉, 石部敦士, 松尾憲一, 簾田康一郎, 仲野明

日本大腸肛門病学会雑誌 65 ( 9 ) 712 - 712 2012年9月

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記述言語：日本語出版者・発行元：(一社)日本大腸肛門病学会

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自然破裂で発症した肝内胆管未分化癌の1例

松尾憲一, 田鍾寛, 春田浩一, 土屋伸広, 佐藤渉, 石部敦士, 山岸茂, 簾田康一郎, 仲野明

胆道 26 ( 3 ) 468 - 468 2012年8月

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記述言語：日本語出版者・発行元：日本胆道学会

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当院における外傷性肝損傷の検討

春田浩一, 松尾憲一, 田鐘寛, 土屋伸広, 田中優作, 佐藤渉, 石部敦士, 山岸茂, 簾田康一郎, 仲野明

日本消化器外科学会総会 67回 1 - 1 2012年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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当院における標準的腹腔鏡補助下左側横行結腸切除術

佐藤渉, 山岸茂, 田鐘寛, 春田浩一, 田中優作, 石部敦士, 松尾憲一, 簾田康一郎, 仲野明

日本消化器外科学会総会 67回 1 - 1 2012年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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腹腔鏡補助下低位前方切除術におけるJ型腸管クランプ鉗子を用いた腸管洗浄切離法

山岸茂, 石部敦士, 田鐘寛, 佐藤渉, 春田浩一, 土屋伸広, 田中優作, 松尾憲一, 簾田康一郎, 仲野明

日本消化器外科学会総会 67回 1 - 1 2012年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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局所進行膵体部癌に対する腹腔動脈合併切除を伴う尾側膵切除の2例

松尾憲一, 簾田康一郎, 田中優作, 田鍾寛, 春田浩一, 土屋伸広, 佐藤渉, 石部敦士, 山岸茂, 仲野明

日本消化器外科学会総会 67回 1 - 1 2012年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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左側大腸癌イレウスに対する経肛門イレウス管による腸管減圧の意義

石部敦士, 山岸茂, 田鍾, 土屋伸広, 春田浩一, 田中優作, 佐藤渉, 松尾憲一, 簾田康一郎, 仲野明

日本消化器外科学会総会 67回 1 - 1 2012年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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弧発性骨盤内神経線維腫の一例

田鍾寛, 山岸茂, 春田浩一, 土屋伸広, 田中優作, 佐藤渉, 石部敦士, 松尾憲一, 簾田康一郎, 仲野明

日本消化器外科学会総会 67回 3 - 3 2012年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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当院における胃GIST切除症例の検討

田中優作, 山岸茂, 田鍾寛, 土屋伸広, 春田浩一, 佐藤渉, 石部敦士, 松尾憲一, 簾田康一郎, 仲野明

日本消化器外科学会総会 67回 1 - 1 2012年7月

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記述言語：日本語出版者・発行元：(一社)日本消化器外科学会

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局所陰圧閉鎖療法により術後早期に遅延一次縫合し得た下部消化管穿孔による汎発性腹膜炎の2例

佐藤渉, 田鐘寛, 春田浩一, 土屋伸宏, 田中優作, 石部敦士, 山岸茂, 松尾憲一, 簾田康一郎, 仲野明, 新村智子, 内藤亜由美

日本ストーマ・排泄リハビリテーション学会誌 28 ( 2 ) 61 - 61 2012年6月

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記述言語：日本語出版者・発行元：日本ストーマ・排泄リハビリテーション学会

J-GLOBAL

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大腸憩室疾患の手術的治療

仲野明, 土屋伸広, 山岸茂, 石部敦士, 佐藤渉, 田中優作, 田鐘寛, 松尾憲一

胃と腸 47 ( 7 ) 1111 - 1117 2012年6月

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記述言語：日本語

DOI： 10.11477/mf.1403113523

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ストーマ粘膜皮膚離開部に交通し腸瘻が存在した正中離開創に対しV.A.C.ATSシステムを用いて創閉鎖に至った一症例

塚田典子, 本間せき子, 今井重成, 松尾憲一, 簾田康一郎, 佐藤渉, 田中優作, 春田浩一, 仲野明

日本ストーマ・排泄リハビリテーション学会誌 28 ( 2 ) 62 - 62 2012年6月

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記述言語：日本語出版者・発行元：日本ストーマ・排泄リハビリテーション学会

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胆管嚢胞腺癌の3切除例

松尾憲一, 簾田康一郎, 田鍾寛, 春田浩一, 土屋伸広, 田中優作, 佐藤渉, 石部敦士, 山岸茂, 権藤俊一, 仲野明

日本肝胆膵外科学会・学術集会プログラム・抄録集 24th 496 - 496 2012年5月

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記述言語：日本語出版者・発行元：(一社)日本肝胆膵外科学会

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直腸癌に対する局所切除術の治療成績

佐藤渉, 山岸茂, 田鐘寛, 春田浩一, 土屋伸宏, 田中優作, 石部敦士, 松尾憲一, 簾田康一郎, 仲野明

日本外科学会雑誌 113 ( 臨増2 ) 535 - 535 2012年3月

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記述言語：日本語出版者・発行元：(一社)日本外科学会

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当院における外傷性肝損傷の検討

春田浩一, 松尾憲一, 田鍾寛, 土屋伸広, 田中優作, 佐藤渉, 石部敦士, 山岸茂, 簾田康一郎, 仲野明

日本外科学会雑誌 113 ( 臨増2 ) 548 - 548 2012年3月

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記述言語：日本語出版者・発行元：(一社)日本外科学会

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当院における大腸癌術後SSIの検討

田鍾寛, 山岸茂, 春田浩一, 土屋伸広, 田中優作, 佐藤渉, 石部敦士, 松尾憲一, 簾田康一郎, 江口和哉, 仲野明

日本外科学会雑誌 113 ( 臨増2 ) 654 - 654 2012年3月

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記述言語：日本語出版者・発行元：(一社)日本外科学会

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新しい手術器機の開発(大腸・肛門) 腹腔鏡下左側大腸切除術における腸管洗浄切離法の工夫

山岸茂, 石部敦士, 佐藤渉, 田中優作, 松尾憲一, 簾田康一郎, 藤井正一, 國崎主税, 遠藤格, 仲野明

日本内視鏡外科学会雑誌 16 ( 7 ) 338 - 338 2011年12月

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記述言語：日本語出版者・発行元：(一社)日本内視鏡外科学会

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当院における腹腔鏡補助下大腸切除術の検討

石部敦士, 山岸茂, 田鍾寛, 土屋伸広, 春田浩一, 佐藤渉, 田中優作, 松尾憲一, 簾田康一郎, 仲野明

日本内視鏡外科学会雑誌 16 ( 7 ) 531 - 531 2011年12月

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記述言語：日本語出版者・発行元：(一社)日本内視鏡外科学会

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当院における大腸癌術後Surgical site infection(SSI)の現状

佐藤渉, 山岸茂, 仲野明, 田鐘寛, 春田浩一, 土屋伸宏, 田中優作, 石部敦士, 松尾憲一, 簾田康一郎, 江口和哉

日本臨床外科学会雑誌 72 ( 増刊 ) 705 - 705 2011年10月

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当院における左側横行結腸に対する腹腔鏡補助下横行結腸切除術

山岸茂, 石部敦士, 土屋信広, 田鍾寛, 春田浩一, 佐藤渉, 松尾憲一, 簾田康一郎, 仲野明

日本臨床外科学会雑誌 72 ( 増刊 ) 456 - 456 2011年10月

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J-GLOBAL

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右側結腸手術における機能的端端吻合(SFEEA)の工夫と成績

土屋伸広, 山岸茂, 田鍾寛, 春田浩一, 佐藤渉, 田中優作, 松尾憲一, 簾田康一郎, 仲野明

日本臨床外科学会雑誌 72 ( 増刊 ) 696 - 696 2011年10月

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大腸癌卵巣転移症例の腹膜播種分類における妥当性の検討

石部敦士, 山岸茂, 田鍾寛, 土屋伸広, 春田浩一, 佐藤渉, 田中優作, 松尾憲一, 簾田康一郎, 江口和哉, 仲野明

日本臨床外科学会雑誌 72 ( 増刊 ) 676 - 676 2011年10月

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絞扼性イレウスの診断における判別式の有用性についての検討

田鍾寛, 山岸茂, 春田浩一, 土屋伸広, 田中優作, 佐藤渉, 石部敦士, 松尾憲一, 簾田康一郎, 仲野明

日本臨床外科学会雑誌 72 ( 増刊 ) 924 - 924 2011年10月

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クリニカルパスへの取り組みとその効果(小腸・大腸・肛門) 当院における大腸切除クリニカルパスの現況と効果

田中優作, 山岸茂, 石部敦士, 田鐘寛, 土屋伸広, 春田浩一, 佐藤渉, 松尾憲一, 簾田康一郎, 仲野明

日本臨床外科学会雑誌 72 ( 増刊 ) 388 - 388 2011年10月

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当院における標準的腹腔鏡補助下左側横行結腸切除術

山岸茂, 石部敦士, 土屋伸広, 佐藤渉, 松尾憲一, 簾田康一郎, 仲野明

日本大腸こう門病学会雑誌 64 ( 9 ) 729 - 729 2011年9月

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記述言語：日本語出版者・発行元：(一社)日本大腸肛門病学会

J-GLOBAL

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当院における大腸憩室症に対する手術症例の検討

土屋伸広, 山岸茂, 石部敦士, 佐藤渉, 松尾憲一, 簾田康一郎, 仲野明

日本大腸こう門病学会雑誌 64 ( 9 ) 778 - 778 2011年9月

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記述言語：日本語出版者・発行元：(一社)日本大腸肛門病学会

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大腸癌イレウス症例におけるイレウスチューブによる腸管減圧の意義

石部敦士, 山岸茂, 佐藤渉, 松尾憲一, 簾田康一郎, 江口和哉, 仲野明

日本大腸こう門病学会雑誌 64 ( 9 ) 744 - 744 2011年9月

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記述言語：日本語出版者・発行元：(一社)日本大腸肛門病学会

J-GLOBAL

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十二指腸乳頭部高分化型神経内分泌癌の1例

松尾憲一, 簾田康一郎, 田鍾寛, 春田浩一, 土屋伸広, 田中優作, 佐藤渉, 石部敦士, 山岸茂, 仲野明

胆道 25 ( 3 ) 538 - 538 2011年8月

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記述言語：日本語出版者・発行元：日本胆道学会

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