研究者詳細 - 三枝祐輔

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写真a

サイグサ　ユウスケ

三枝祐輔

Yusuke Saigusa

所属

附属病院次世代臨床研究センター講師

プロフィール

離散データ、クラスターデータ、経時測定データ等の統計解析手法の開発に取り組み、医学研究や生態学研究におけるデータへの応用を研究している。日本計量生物学会の実務試験統計家に認定されている。

外部リンク

学位

博士（理学）（東京理科大学）

研究キーワード

生態学
医学
統計学
機械学習

研究分野

自然科学一般 / 応用数学、統計数学
情報通信 / 統計科学

学歴

東京理科大学理工学研究科情報科学専攻

2012年4月 - 2017年3月

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東京理科大学理工学部情報科学科

2008年4月 - 2012年3月

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経歴

横浜市立大学附属病院次世代臨床研究センター統計解析室室長

2024年4月 - 現在

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横浜市立大学医学部臨床統計学講師

2023年4月 - 現在

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横浜市立大学附属病院次世代臨床研究センター統計解析室

2017年4月 - 2024年3月

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横浜市立大学医学部臨床統計学助教

2017年4月 - 2023年3月

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所属学協会

日本計算機統計学会

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日本統計学会

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応用統計学会

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日本計量生物学会（国際会員）（実務試験統計家）

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委員歴

応用統計学会評議員・企画理事

2024年4月 - 現在

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統計質保証推進協会統計検定問題策定委員会研究分科会委員

2020年5月 - 現在

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統計関連学会連合運営委員

2019年4月 - 2021年3月

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団体区分：学協会

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横浜市立大学臨床研究審査委員会技術専門員

2018年4月 - 2020年3月

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団体区分：学協会

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論文

Bayesian method for comparing F1 scores in the absence of a gold standard. 査読国際誌

Jun Tamura, Yusuke Saigusa, Junichi Fujita, Kouji Yamamoto

Journal of Biopharmaceutical Statistics 1 - 10 2025年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

In the field of medicine, evaluating the diagnostic performance of new diagnostic methods can be challenging, especially in the absence of a gold standard. This study proposes a methodology for assessing the performance of diagnostic tests by estimating the posterior distribution of the F1 score using latent class analysis, without relying on a gold standard. The proposed method utilizes Markov Chain Monte Carlo sampling to estimate the posterior distribution of the F1 score, enabling a comprehensive evaluation of diagnostic test methods. By applying this method to internet addiction, we demonstrate how latent class analysis can be effectively used to assess diagnostic performance, offering a practical solution for situations where no gold standard is available. The effectiveness of the proposed approach was evaluated through simulation studies by examining the coverage probability of the 95% highest density interval of the estimated posterior distributions.

DOI： 10.1080/10543406.2025.2450319

PubMed

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Head-to-head comparison among FAST, MAST, and multiparametric MRI-based new score in diagnosing at-risk MASH. 査読国際誌

Kento Imajo, Yusuke Saigusa, Takashi Kobayashi, Koki Nagai, Shinya Nishida, Nobuyoshi Kawamura, Hiroyoshi Doi, Michihiro Iwaki, Asako Nogami, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Hiroyuki Kirikoshi, Shigehiro Kokubu, Daisuke Utsunomiya, Hirokazu Takahashi, Shinichi Aishima, Yoshio Sumida, Satoru Saito, Masato Yoneda, Andrea Dennis, Stella Kin, Anneli Andersson, Atsushi Nakajima

European Radiology https://doi.org/10.1007/s00330-024-11215-3 2024年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: New scores were developed to identify at-risk metabolic dysfunction-associated steatohepatitis (MASH) using multiparametric MRI (mpMRI). MATERIALS AND METHODS: A prospective study was conducted on 176 patients with suspected or diagnosed metabolic dysfunction-associated steatotic liver disease (MASLD) paired with an MR scan, vibration-controlled transient elastography (VCTE), and liver biopsy. Liver stiffness measurement (LSM) using magnetic resonance elastography (MRE), proton density fat fraction (PDFF), and mpMRI-based corrected T1 (cT1) were combined to develop a one-step strategy, named MPcT (MRE + PDFF + cT1, combined score), and a two-step strategy-MRE-based LSM followed by PDFF with cT1 (M-PcT, paired score) for diagnosing at-risk MASH. Each model was categorized using rule-in and rule-out criteria (three categorized analyses). To avoid overfitting, the diagnostic accuracies were evaluated based on 5-fold cross-validation. RESULTS: PDFF + cT1 (PcT) had the highest diagnostic performance for severe activity (hepatic inflammation plus ballooning grade ≥ 3) and for NAS ≥ 4 (active MASH). Areas under receiver operating characteristic curves (AUROCs) of M-PcT (0.832) for detecting at-risk MASH were significantly higher than those of Fibroscan-AST (FAST) (0.744, p = 0.017), MRI-AST (MAST) (0.710, p = 0.002), and MPcT (0.695, p < 0.001) in three categorized analysis. Following the rule-in criteria, positive predictive values of M-PcT (84.5%) were higher than those of FAST (73.5%), MAST (70.0%), and MPcT (66.7%). Following the rule-out criteria, negative predictive values of M-PcT (88.7%) were higher than those of FAST (84.0%), MAST (73.9%), and MPcT (84.9%). CONCLUSIONS: The two-step strategy, M-PcT (paired score), showed the reliability of rule-in/-out for at-risk MASH, with better predictive performance compared with FAST and MAST (combined score). CLINICAL TRIAL REGISTRATION: This study is registered with ClinicalTrials.gov (number, UMIN000012757). KEY POINTS: Question There is no mpMRI-based method for detecting as-risk MASH (NAFLD activity score ≥ 4 with fibrosis stage ≥ 2) like FAST and MAST scores. Findings MRE-based LSMs followed by PDFF with cT1 (M-PcT) were more useful in detecting at-risk MASH than the combined score (FAST and MAST). Clinical relevance By combining MRE and PDFF with cT1, it becomes possible to evaluate the pathology of MASH without the need for a liver biopsy, assisting in prognosis prediction and decision-making for treatment options.

DOI： 10.1007/s00330-024-11215-3

PubMed

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Hypotension after general anaesthesia induction using remimazolam or propofol in geriatric patients undergoing sevoflurane anaesthesia with remifentanil: a single-centre, double-blind, randomised controlled trial. 査読国際誌

Ryuki Takaki, Masashi Yokose, Takahiro Mihara, Yusuke Saigusa, Hiroyuki Tanaka, Natsuhiro Yamamoto, Kenichi Masui, Takahisa Goto

British Journal of Anaesthesia 133 ( 1 ) 24 - 32 2024年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The occurrence of hypotension after induction of general anaesthesia is common in geriatric patients, and should be prevented to minimise perioperative complications. Compared with propofol, remimazolam potentially has a lower incidence of hypotension. This study aimed to compare the incidence of hypotension after general anaesthesia induction with remimazolam or propofol in geriatric patients. METHODS: This single-centre, double-blind, randomised trial enrolled 90 patients aged ≥80 yr who received general anaesthesia for scheduled surgery. Patients were randomised to receive remimazolam (12 mg kg-1 h-1) or propofol (0.025 mg kg-1 s-1) for anaesthesia induction, with remifentanil and sevoflurane. The presence or absence of hypertension on the ward served as the stratification factor. The incidence of hypotension after the induction of general anaesthesia, defined as a noninvasive mean arterial pressure of <65 mm Hg measured every minute from initiation of drug administration to 3 min after tracheal intubation, was the primary outcome. Subgroup analysis was performed for the primary outcome using preoperative ward hypertension, clinical frailty scale, Charlson Comorbidity Index, and age. RESULTS: Three subjects were excluded before drug administration, and 87 subjects were included in the analysis. The incidence of hypotension was 72.1% (31/43) and 72.7% (32/44) with remimazolam or propofol, respectively. No statistically significant differences (adjusted odds ratio, 0.96; 95% confidence interval, 0.37-2.46; P=0.93) were observed between groups. Subgroup analysis revealed no significant differences between groups. CONCLUSIONS: Compared with propofol, remimazolam did not reduce the incidence of hypotension after general anaesthesia induction in patients aged ≥80 yr. CLINICAL TRIAL REGISTRATION: UMIN000042587.

DOI： 10.1016/j.bja.2024.04.013

PubMed

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Robust minimum divergence estimation in a spatial Poisson point process 査読

Yusuke Saigusa, Shinto Eguchi, Osamu Komori

Ecological Informatics 81 102569 2024年3月

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担当区分：筆頭著者,　責任著者

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区間打ち切りデータとしての無増悪生存時間の解析方法の理論的およびシミュレーションによる検討査読

西川正子, 西川智美, 三枝祐輔, 森川敏彦, 山本紘司

計量生物学 45 ( 1 ) 87 - 113 2024年

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A Learning Program for Treatment Recommendations by Molecular Tumor Boards and Artificial Intelligence 査読

Kuniko Sunami, Yoichi Naito, Yusuke Saigusa, Toraji Amano, Daisuke Ennishi, Mitsuho Imai, Hidenori Kage, Masashi Kanai, Hirotsugu Kenmotsu, Keigo Komine, Takafumi Koyama, Takahiro Maeda, Sachi Morita, Daisuke Sakai, Makoto Hirata, Mamoru Ito, Toshiyuki Kozuki, Hiroyuki Sakashita, Hidehito Horinouchi, Yusuke Okuma, Atsuo Takashima, Toshio Kubo, Shuichi Hironaka, Yoshihiko Segawa, Yoshihiro Yakushijin, Hideaki Bando, Akitaka Makiyama, Tatsuya Suzuki, Ichiro Kinoshita, Shinji Kohsaka, Yuichiro Ohe, Chikashi Ishioka, Kouji Yamamoto, Katsuya Tsuchihara, Takayuki Yoshino

JAMA Oncology 10 ( 1 ) 95 - 102 2023年11月

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掲載種別：研究論文（学術雑誌）出版者・発行元：American Medical Association (AMA)

Importance

Substantial heterogeneity exists in treatment recommendations across molecular tumor boards (MTBs), especially for biomarkers with low evidence levels; therefore, the learning program is essential.

Objective

To determine whether a learning program sharing treatment recommendations for biomarkers with low evidence levels contributes to the standardization of MTBs and to investigate the efficacy of an artificial intelligence (AI)–based annotation system.

Design, Setting, and Participants

This prospective quality improvement study used 50 simulated cases to assess concordance of treatment recommendations between a central committee and participants. Forty-seven participants applied from April 7 to May 13, 2021. Fifty simulated cases were randomly divided into prelearning and postlearning evaluation groups to assess similar concordance based on previous investigations. Participants included MTBs at hub hospitals, treating physicians at core hospitals, and AI systems. Each participant made treatment recommendations for each prelearning case from registration to June 30, 2021; participated in the learning program on July 18, 2021; and made treatment recommendations for each postlearning case from August 3 to September 30, 2021. Data were analyzed from September 2 to December 10, 2021.

Exposures

The learning program shared the methodology of making appropriate treatment recommendations, especially for biomarkers with low evidence levels.

Main Outcomes and Measures

The primary end point was the proportion of MTBs that met prespecified accreditation criteria for postlearning evaluations (approximately 90% concordance with high evidence levels and approximately 40% with low evidence levels). Key secondary end points were chronological enhancements in the concordance of treatment recommendations on postlearning evaluations from prelearning evaluations. Concordance of treatment recommendations by an AI system was an exploratory end point.

Results

Of the 47 participants who applied, 42 were eligible. The accreditation rate of the MTBs was 55.6% (95% CI, 35.3%-74.5%; P &amp;lt; .001). Concordance in MTBs increased from 58.7% (95% CI, 52.8%-64.4%) to 67.9% (95% CI, 61.0%-74.1%) (odds ratio, 1.40 [95% CI, 1.06-1.86]; P = .02). In postlearning evaluations, the concordance of treatment recommendations by the AI system was significantly higher than that of MTBs (88.0% [95% CI, 68.7%-96.1%]; P = .03).

Conclusions and Relevance

The findings of this quality improvement study suggest that use of a learning program improved the concordance of treatment recommendations provided by MTBs to central ones. Treatment recommendations made by an AI system showed higher concordance than that for MTBs, indicating the potential clinical utility of the AI system.

DOI： 10.1001/jamaoncol.2023.5120

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Blood perfusion assessment by indocyanine green fluorescence imaging for minimally invasive rectal cancer surgery (EssentiAL trial): A randomized clinical trial 査読

Watanabe J, Takemasa I, Kotake M, Noura S, Kimura K, Suwa H, Tei M, Takano Y, Munakata K, Matoba S, Yamagishi S, Yasui M, Kato T, Ishibe A, Shiozawa M, Ishii Y, Yabuno T, Nitta T, Saito S, Saigusa Y, Watanabe M

Annals of Surgery Online Published 2023年5月

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Statistical learning for species distribution models in ecological studies 査読

Komori O, Saigusa Y, Eguchi S

Japanese Journal of Statistics and Data Science Online Published 2023年5月

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DOI： 10.1007/s42081-023-00206-1

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Concordance between recommendations from multidisciplinary molecular tumor boards and central consensus for cancer treatment in Japan 査読

Naito Y, Sunami K, Kage H, Komine K, Amano T, Imai M, Koyama T, Ennishi D, Kanai M, Kenmotsu H, Maeda T, Morita S, Sakai D, Watanabe K, Shirota H, Kinoshita I, Yoshioka M, Mamesaya N, Ito M, Kohsaka S, Saigusa Y, Yamamoto K, Hirata M, Tsuchihara K, Yoshino T

JAMA Network Open 5 ( 12 ) e2245081 2022年12月

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Measure of departure from conditional partial symmetry for square contingency tables 査読

Saigusa Y, Fukumoto N, Nakagawa T, Tomizawa S

Journal of Mathematics and Statistics Accepted 2022年9月

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担当区分：筆頭著者,　責任著者

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Geometric mean type measure of the departure from partial symmetry for ordinal square contingency tables 査読

Saigusa Y, Yano T, Ishii A, Tomizawa S

Advances and Applications in Statistics 76 127-138 2022年5月

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担当区分：筆頭著者,　責任著者

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Generalized quasi-linear mixed-effects model 査読

Saigusa Y, Eguchi S, Komori O

Statistical Methods in Medical Research 31 ( 7 ) 1280 - 1291 2022年3月

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担当区分：筆頭著者,　責任著者

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Effect of nudge-based intervention on adherence to physician visit recommendations and health outcomes among chronic kidney disease 査読

Fukuma S, Sasaki S, Taguri M, Goto R, Misumi T, Saigusa Y, Tsugawa, Y

Journal of the American Society of Nephrology 33 ( 1 ) 175 - 185 2022年1月

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Measure of departure from conditional symmetry based on cumulative probabilities for square contingency tables 査読

Saigusa Y, Teramoto Y, Tomizawa S

Symmetry 13 ( 10 ) 1897 2021年10月

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担当区分：筆頭著者,　責任著者

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Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia 査読国際誌

Nomoto N, Konopaske G T, Yamashita N, Aoki R, Jitsuki-Takahashi A, Nakamura H, Makihara H, Saito M, Saigusa Y, Nakamura F, Watanabe K, Baba T, Benes F M, Tobe B T, Pernia C D, Coyle J T, Sidman R L, Hirayasu Y, Snyder E Y, Goshima Y

Proceedings of the National Academy of Sciences of the United States of America 118 ( 31 ) e2100032118 2021年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1073/pnas.2100032118

PubMed

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Mortality and risk factors on admission in toxic epidermal necrolysis: A cohort study of 59 patients 査読

Watanabe T, Go H, Saigusa Y, Takamura N, Watanabe Y, Yamane Y, Totsuka M, Ishikawa H, Nakamura K, Matsukura S, Kambara T, Takaki S, Yamaguchi Y, Aihara, M

Allergology International 70 2020年12月

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Measure of departure from cumulative local symmetry for square contingency tables having ordered categories 査読

Saigusa Y, Takada T, Ishii A, Nakagawa T, Tomizawa S

Biometrical Letters 57 ( 1 ) 23 - 35 2020年6月

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担当区分：筆頭著者,　責任著者

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A measure of departure from partial marginal homogeneity for square contingency tables 査読

Saigusa, Y, Kubo, Y, Tahata, K, Tomizawa, S

Journal of Statistics Applications and Probability Letters 7 ( 1 ) 1 - 7 2020年

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担当区分：筆頭著者,　責任著者掲載種別：研究論文（学術雑誌）

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Coronary flow reserve by cardiac magnetic resonance imaging in patients with diabetes mellitus 査読

Kato, S, Fukui, K, Saigusa, Y, Kubota, K, Kodama, S, Asahina, N, Hayakawa, K, Igushi, K, Fukuoka, M, Iwasawa, T, Utsunomiya, D, Kosuge, M, Kimura, K, Tamura, K

JACC: Cardiovascular Imaging 12 ( 12 ) 2579 - 2580 2019年12月

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掲載種別：研究論文（学術雑誌）

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Radiotherapy for hepatocellular carcinoma results in comparable survival to radiofrequency ablation: A propensity score analysis 査読

Hara, K, Takeda, A, Tsurugai, Y, Saigusa, Y, Sanuki, N, Eriguchi, T, Maeda, S, Tanaka, K, Numata, K

Hepatology 69 2533 - 2545 2019年6月

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Measure for departure from cumulative partial symmetry for square contingency tables with ordered categories 査読

Saigusa, Y, Takami, M, Ishii, A, Nakagawa, T, Tomizawa, S

Journal of Statistics: Advances in Theory and Applications 21 53 - 70 2019年

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担当区分：筆頭著者,　責任著者

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Robust bias correction model for estimation of global trend in marine populations 査読

Komori, O, Eguchi, S, Saigusa, Y, H. Okamura, H, Ichinokawa, M

Ecosphere 8 ( 12 ) 2017年

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1002/ecs2.2038

Web of Science

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Decompositions of symmetry using extended palindromic symmetry models for square contingency tables 査読

Saigusa, Y, Tahata, K, Tomizawa, S

Journal of Statistical Theory and Practice 10 1 - 6 2016年

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担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1080/15598608.2015.1048396

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Measure of departure from partial symmetry for square contingency tables 査読

Saigusa, Y, Tahata, K, Tomizawa, S

Journal of Mathematics and Statistics 12 152 - 156 2016年

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担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.3844/jmssp.2016.152.156

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Orthogonal decomposition of symmetry model using ordinal quasi-symmetry model based on f-divergence for square contingency tables 査読

Saigusa, Y, Tahata, K, Tomizawa, S

Statistics and Probability Letters 101 33 - 37 2015年

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担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.spl.2015.02.023

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An extended asymmetry model for square contingency tables with ordered categories 査読

Saigusa, Y, Tahata, K, Tomizawa, S

Model Assisted Statistics and Applications: An International Journal 9 151 - 157 2014年

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担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.3233/MAS-130286

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Usefulness of magnifying endoscopy with narrow-band imaging for diagnosis of ulcerative colitis-associated neoplasia 査読国際誌

Masafumi Nishio, Kingo Hirasawa, Yusuke Saigusa, Zhao Shiqi, Tokomi Kenemura, Takanori Hama, Reo Atsusaka, Daisuke Azuma, Yuichiro Ozeki, Atsushi Sawada, Ryosuke Ikeda, Takehide Fukuchi, Ryosuke Kobayashi, Chiko Sato, Tsuyoshi Ogashiwa, Sawako Chiba, Yoshiaki Inayama, Reiko Kunisaki, Shin Maeda

Journal of Gastroenterology and Hepatology 40 ( 4 ) 900 - 906 2025年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND AND AIM: Qualitative diagnosis of ulcerative colitis-associated neoplasia (UCAN) is crucial for surveillance colonoscopy in patients with ulcerative colitis (UC). Although the utility of magnifying endoscopy with narrow-band imaging (ME-NBI) in sporadic neoplasia diagnosis has been reported, its efficacy in UCAN remains unclear. This study aimed to evaluate the usefulness of ME-NBI for qualitative diagnosis of UCAN. METHODS: We generated 60 ME-NBI images (30 UCANs and 30 nonneoplasia lesions, including 10 polypoid and 20 nonpolypoid lesions) from patients with UC who underwent colonoscopy at our hospital between 2015 and 2023. Eleven endoscopists (seven experts and four trainees) independently assessed these images. Lesions were categorized into high- (≥ 80%), moderate- (50%-79%), and low- (< 50%) accuracy groups on the basis of the correct diagnostic rate. RESULTS: Overall sensitivity, specificity, and correct diagnostic rates were 66.5%, 79.0%, and 71.8%, respectively. Experts tended to exhibit higher specificity than trainees (83% vs. 70%). Polypoid lesions showed higher sensitivity (92% vs. 54%) and lower specificity (61% vs. 88%) than nonpolypoid lesions. Overall, the kappa value was 0.411. In UCAN, 37%, 37%, and 24% were classified into the high-, moderate-, and low-accuracy groups, respectively. All endoscopists assessed one case of UCAN in the low-accuracy group as a nonneoplastic vessel with a surface pattern. Only two nonneoplasias were identified as having nonneoplastic vessel and surface patterns by all endoscopists. CONCLUSIONS: This study demonstrated the usefulness of ME-NBI for qualitative diagnosis, along with its limitations. A unique endoscopic diagnostic algorithm for UCAN, incorporating ME-NBI and other modalities, is necessary.

DOI： 10.1111/jgh.16877

PubMed

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Novel machine-learning model for predicting lymph node metastasis in resectable pancreatic ductal adenocarcinoma. 査読

Susumu Daibo, Yuki Homma, Hiroki Ohya, Hironori Fukuoka, Kentaro Miyake, Mayumi Ozawa, Takafumi Kumamoto, Ryusei Matsuyama, Yusuke Saigusa, Itaru Endo

Annals of Gastroenterological Surgery 9 ( 1 ) 161 - 168 2025年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

AIM: Lymph node metastasis is an adverse prognostic factor in pancreatic ductal adenocarcinoma. However, it remains a challenge to predict lymph node metastasis using preoperative imaging alone. We used machine learning (combining preoperative imaging findings, tumor markers, and clinical information) to create a novel prediction model for lymph node metastasis in resectable pancreatic ductal adenocarcinoma. METHODS: The data of patients with resectable pancreatic ductal adenocarcinoma who underwent surgery between September 1991 and October 2022 were retrospectively examined. Machine-learning software (Statistical Package for the Social Sciences Modeler) was used to create a prediction model, and parameter tuning was performed to improve the model's accuracy. We also analyzed the contribution of each feature to prediction using individual conditional expectation and partial dependence plots. RESULTS: Of the 331 cases included in the study, 241 comprised the training cohort and 90 comprised the test cohort. After parameter tuning, the areas under the receiver operating characteristic curves for the training and test cohorts were 0.780 and 0.795, respectively. Individual conditional expectation and partial dependence plots showed that larger tumor size and carbohydrate antigen 19-9 and Duke pancreatic monoclonal antigen type 2 levels were associated with positive lymph node metastasis prediction in this model; neoadjuvant treatment was associated with negative lymph node metastasis prediction. CONCLUSION: Machine learning may contribute to the creation of an effective predictive model of lymph node metastasis in pancreatic ductal adenocarcinoma. Prediction models using machine learning may contribute to the development of new treatment strategies in resectable pancreatic ductal adenocarcinoma.

DOI： 10.1002/ags3.12836

PubMed

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Retrospective observational study on telemedicine in sublingual immunotherapy for patients with Japanese cedar pollinosis and house dust mite allergic rhinitis 査読国際誌

Yumi Inoo, Hiroshi Iida, Hiroto Nakada, Katsuhiko Tezuka, Yasutake Kikuchi, Eiichi Fujimura, Tasuku Nishikawa, Kazuhiro Yamamoto, Yutaro Ida, Yusuke Saigusa, Takashi Hatano, Masahiko Inamori

Telemedicine Journal and e-health : the official journal of the American Telemedicine Association 31 ( 1 ) 107 - 118 2025年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Introduction: In Japan, telemedicine has gradually expanded due to deregulation in response to the COVID-19 pandemic. However, its current status remains unclear, as it is primarily provided by general practitioners. This study aims to examine the use of telemedicine in sublingual immunotherapy (SLIT) for patients with Japanese cedar pollen allergy and/or house dust mite allergic rhinitis. Methods: We conducted a retrospective analysis of medical record data from seven otorhinolaryngology clinics and performed an exploratory evaluation between a group that combined telemedicine and in-person visits during the initial 6 months of SLIT and another group with only in-person visits. Results: Following propensity score matching, 51 and 82 patients were eligible for the telemedicine and in-person groups, respectively, with 33 cases in both groups. Both groups had similar characteristics after matching. No significant difference was found in the withdrawal rate at 6 months from the start of SLIT (6.1% and 9.1% in each group; p = 1.00), side effects, or treatment efficacy between the two groups. The average copayment for patients tended to be significantly higher in the telemedicine group after one, three, and 6 months following SLIT initiation. Discussion: The situation of patients who receive an appropriate combination of telemedicine and in-person visits is not significantly different from patients who receive in-person visits alone. This study may help indicate the actual status of telemedicine in Japan. Further investigation at more facilities is necessary in the future to dispel concerns in the practice setting.

DOI： 10.1089/tmj.2024.0065

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Effectiveness of mental health education for high school teachers in Japan: A prospective cohort study 査読

Junichi Fujita, Tsukasa Sasaki, Hidehito Miyazaki, Yusuke Saigusa, Noriko Mochida, Kumi Aoyama, Yuichi Takahashi, Chiaki Hironai, Kyohei Yamamoto, Nao Toyohara, Noriaki Nakamura, Akitoyo Hishimoto

Quality in Primary Care 32 ( 3 ) 2024年6月

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DOI： 10.36648/1479-1064.32.2.11

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Clinical features of patients with systemic sclerosis positive for anti-SS-A antibody: a cohort study of 156 patients. 査読国際誌

Tomoya Watanabe, Yasushi Ototake, Asami Akita, Mao Suzuki, Miwa Kanaoka, Jun Tamura, Yusuke Saigusa, Yukie Yamaguchi

Arthritis Research & Therapy 26 ( 1 ) 93 - 93 2024年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Anti-SS-A/Ro antibody (anti-SSA), the diagnostic marker of Sjögren's syndrome (SS), is often detected in systemic sclerosis (SSc). Some patients are diagnosed with SSc/SS overlap syndromes, while there are anti-SSA-positive SSc cases without SS. In this study, we investigated the clinical characteristics of SSc with anti-SSA and clarified the clinical impact of this antibody in SSc. METHODS: A retrospective chart review was conducted of 156 patients with SSc at Yokohama City University Hospital from 2018 to 2021. Clinical data, laboratory data, imaging, and autoantibody positivity status were collected and analysed to assess the association between these variables and anti-SSA using multivariable logistic regression analysis. RESULTS: This cohort included 18 men and 138 women with SSc (median age, 69.0 years). Thirty-nine patients had diffuse cutaneous SSc (dcSSc) (25%), and 117 patients had limited cutaneous SSc (75%). Forty-four patients were anti-SSA-positive. Among them, 24 fulfilled the SS criteria. Multivariable logistic regression revealed that anti-SSA was statistically associated with interstitial lung disease (ILD; odds ratio [OR] = 2.67; 95% confidence interval [CI], 1.14-6.3; P = 0.024). Meanwhile, anti-SSA positivity tended to increase the development of digital ulcer (OR = 2.18; 95% CI, 0.99-4.82, P = 0.054). In the comparative analysis of the autoantibody single-positive and anti-SSA/SSc-specific autoantibody double-positive groups, the anti-SSA single-positive group showed a significantly increased risk of ILD (OR = 12.1; 95% CI, 2.13-140.57; P = 0.003). Furthermore, patients with SSc and anti-SSA indicated that anti-SSA-positive SSc without SS was strongly associated with dcSSc when compared to that in patients with SS (OR = 6.45; 95% CI, 1.23-32.60; P = 0.024). CONCLUSIONS: Anti-SSA positivity increases the risk of organ involvement, such as ILD, in patients with SSc. Additionally, the anti-SSA-positive SSc without SS population may have more severe skin fibrosis than others. Anti-SSA may be a potential marker of ILD and skin severity in SSc.

DOI： 10.1186/s13075-024-03325-6

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Chronic Effects of Adaptive Servo-Ventilation Therapy on Mortality and the Urgent Rehospitalization Rate in Patients Experiencing Recurrent Admissions for Heart Failure - A Multicenter Prospective Observational Study (SAVIOR-L). 査読

Yoshihiro Fukumoto, Takeshi Tada, Hideaki Suzuki, Yuji Nishimoto, Kenji Moriuchi, Takuo Arikawa, Hitoshi Adachi, Shin-Ichi Momomura, Yoshihiko Seino, Yoshio Yasumura, Hiroyuki Yokoyama, Go Hiasa, Takayuki Hidaka, Shoichiro Nohara, Hideki Okayama, Hiroyuki Tsutsui, Takatoshi Kasai, Yoshifumi Takata, Mika Enomoto, Yusuke Saigusa, Kouji Yamamoto, Koichiro Kinugawa, Yasuki Kihara

Circulation Journal : Official journal of the Japanese Circulation Society 88 ( 5 ) 692 - 702 2024年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: This study investigated whether the chronic use of adaptive servo-ventilation (ASV) reduces all-cause mortality and the rate of urgent rehospitalization in patients with heart failure (HF). METHODS AND RESULTS: This multicenter prospective observational study enrolled patients hospitalized for HF in Japan between 2019 and 2020 who were treated either with or without ASV therapy. Of 845 patients, 110 (13%) received chronic ASV at hospital discharge. The primary outcome was a composite of all-cause death and urgent rehospitalization for HF, and was observed in 272 patients over a 1-year follow-up. Following 1:3 sequential propensity score matching, 384 patients were included in the subsequent analysis. The median time to the primary outcome was significantly shorter in the ASV than in non-ASV group (19.7 vs. 34.4 weeks; P=0.013). In contrast, there was no significant difference in the all-cause mortality event-free rate between the 2 groups. CONCLUSIONS: Chronic use of ASV did not impact all-cause mortality in patients experiencing recurrent admissions for HF.

DOI： 10.1253/circj.CJ-23-0827

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Lipoprotein Apheresis Alleviates Treatment-Resistant Peripheral Artery Disease Despite the Normal Range of Atherogenic Lipoproteins: The LETS-PAD Study. 査読

Eiko Ueda, Yoshiyuki Toya, Hiromichi Wakui, Kohei Ishiga, Yuki Kawai, Ryu Kobayashi, Sho Kinguchi, Tomohiko Kanaoka, Yusuke Saigusa, Taro Mikami, Yuichiro Yabuki, Motohiko Goda, Daisuke Machida, Takayuki Fujita, Kotaro Haruhara, Teruyasu Sugano, Kengo Azushima, Kouichi Tamura

Journal of Atherosclerosis and Thrombosis 31 1370 - 1385 2024年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）

AIM: Peripheral artery disease (PAD) severely impairs patient prognosis and quality of life (QOL). Although lipoprotein apheresis (LA) has been applied to patients with PAD and elevated serum atherogenic lipoproteins, we hypothesized that LA can be effective for treating PAD even in patients with controlled serum lipoproteins through pleiotropic anti-atherosclerotic effects beyond lipoprotein removal. This study aimed to evaluate the efficacy of LA in patients with treatment-resistant PAD and controlled serum lipoproteins focusing on QOL. METHODS: In a single-arm prospective study, 30 patients with refractory PAD who had controlled serum lipoproteins underwent sequential LA sessions using dextran sulfate adsorption columns, aiming to complete 10 sessions. The ankle-brachial pressure index (ABI) and vascular QOL (VascuQOL) score were evaluated as the primary outcomes. Secondary outcomes included reactive hyperemia index (RHI) and biological antioxidant potential (BAP) as an endothelial function test and serum antioxidative-capacity evaluation, respectively. RESULTS: ABI significantly increased after LA sessions (pre-treatment 0.60±0.09 vs. post-treatment 0.65±0.13, p=0.023). Total VascuQOL score (3.7±1.1 vs 4.6±1.1, p＜0.001) and RHI (1.70±0.74 vs 2.34±1.76, p=0.023) significantly improved after the LA sessions. BAP tended to increase after the LA sessions, and the change reached statistical significance 3 months after treatment. CONCLUSION: ABI and QOL improved after a series of LA sessions in conventional treatment-resistant PAD patients with controlled serum lipoprotein levels. Increased antioxidative capacity and ameliorated endothelial function were observed after the LA treatment.

DOI： 10.5551/jat.64639

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Comparison of standardized prophylactic high-dose and intrathecal methotrexate for DLBCL with a high risk of CNS relapse 査読

Masahiro Akimoto, Takuya Miyazaki, Hiroyuki Takahashi, Yusuke Saigusa, Takaaki Takeda, Yuto Hibino, Mayumi Tokunaga, Takuma Ohashi, Ayako Matsumura, Haruka Teshigawara, Taisei Suzuki, Hiroshi Teranaka, Yuki Nakajima, Kenji Matsumoto, Chizuko Hashimoto, Katsumichi Fujimaki, Hiroyuki Fujita, Rika Sakai, Shin Fujisawa, Hideaki Nakajima

International Journal of Hematology 119 ( 2 ) 164 - 172 2024年1月

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掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

DOI： 10.1007/s12185-023-03700-0

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その他リンク： https://link.springer.com/article/10.1007/s12185-023-03700-0/fulltext.html
Immune mediators as predictive biomarkers for anti-PD-1 antibody therapy in urothelial carcinoma. 査読国際誌

Yosuke Shibata, Takeshi Kishida, Taku Kouro, Feifei Wei, Yuka Igarashi, Hidetomo Himuro, Takeaki Noguchi, Mitsuyuki Koizumi, Takahisa Suzuki, Kimito Osaka, Yusuke Saigusa, Tetsuro Sasada

Frontiers in Pharmacology 14 https://doi.org/10.3389/fphar.2023.1269935 2023年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Introduction: This study aimed to identify immune mediators, including cytokines, chemokines, and growth factors, in the plasma for predicting treatment efficacy and immune-related adverse events (irAEs) in advanced urothelial carcinoma (aUC) treated with immune checkpoint inhibitors (ICIs). Methods: We enrolled 57 patients with aUC who were treated with the anti-programmed cell death protein 1 (PD-1) antibody pembrolizumab after the failure of platinum-based chemotherapy between February 2018 and December 2020. Plasma levels of 73 soluble immune mediators were measured before and 6 weeks after initiating pembrolizumab therapy. The association of estimated soluble immune mediators with clinical outcomes, including overall survival (OS), progression-free survival (PFS), anti-tumor responses, and irAEs, were statistically evaluated. Results: In the multivariate analysis, levels of 18 factors at baseline and 12 factors during treatment were significantly associated with OS. Regarding PFS, baseline levels of 17 factors were significantly associated with PFS. Higher levels of interleukin (IL)-6, IL-8, soluble tumor necrosis factor receptor 1 (sTNF-R1), and IL-12 (p40), both at baseline and post-treatment, were significantly associated with worse OS. Conversely, low IL-6 and high TWEAK levels at baseline were associated with irAEs. Among identified factors, interferon (IFN) γ and IL-12 (p40) were repeatedly identified; high baseline levels of these factors were risk factors for worse OS and PFS, as well as progressive disease. Notably, using correlation and principal component analysis, factors significantly associated with clinical outcomes were broadly classified into three groups exhibiting similar expression patterns. Discussion: Measuring plasma levels of soluble immune mediators, such as IL-6, IL-8, sTNF-R1, IFNγ, and IL-12 (p40), could be recommended for predicting prognosis and irAEs in ICI-treated patients with aUC.

DOI： 10.3389/fphar.2023.1269935

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Measurement accuracy of a microwave doppler sensor beneath the mattress as a continuous respiratory rate monitor: a method comparison study 査読

Hiroyuki Tanaka, Masashi Yokose, Shunsuke Takaki, Takahiro Mihara, Yusuke Saigusa, Takahisa Goto

Journal of Clinical Monitoring and Computing 38 ( 1 ) 77 - 88 2023年10月

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掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

DOI： 10.1007/s10877-023-01081-7

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その他リンク： https://link.springer.com/article/10.1007/s10877-023-01081-7/fulltext.html
Protective effect of hydroxychloroquine on infections in patients with systemic lupus erythematosus: an observational study using the LUNA registry 査読

Hidekawa C, Yoshimi R, Saigusa Y, Tamura T, Kojitani N, Suzuki N, Sakurai N, Yoshioka Y, Sugiyama-Kawahara Y, Kunishita K, Kishimoto D, Higashitani K, Sato S, Komiya T, Nagai H, Hamada H, Maeda A, Tsuchida N, Hirahara H, Soejima Y, Takase-Minegishi K, Kirino K, Yajima N, Sada K, Miyawaki M, Ichinose K, Ohno S, Kajiyama K, Sato S, Shimojima Y, Nakajima H

Frontiers in Immunology Online Published 2023年9月

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DOI： 10.3389/fimmu.2023.1227403

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Association of PD-L1 tumor proportion score ≥20% with early resistance to osimertinib in patients with EGFR-mutated NSCLC 査読

Hamakawa Y, Agemi Y, Shiba A, Ikeda T, Higashi Y, Aga M, Miyazaki K, Taniguchi Y, Misumi Y, Nakamura Y, Shimokawa T, Saigusa Y, Kobayashi N, Okamoto H, Kaneko T

Cancer Medicine Online Published 2023年8月

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DOI： 10.1002/cam4.6405

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Stomach position evaluated using computed tomography is related to successful post-pyloric enteral feeding tube placement in critically ill patients: a retrospective observational study 査読

Yokose M, Takaki S, Saigusa Y, Mihara T, Ishiwata Y, Kato S, Horie K, Goto T

Journal of Intensive Care 11 2023年5月

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DOI： 10.1186/s40560-023-00673-4

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Predictors of severe submucosal fibrosis during endoscopic submucosal dissection in patients with ulcerative colitis: Retrospective cohort study 査読

Nishio M, Hirasawa K, Saigusa Y, Atsusaka R, Azuma D, Ozeki Y, Sawada A, Ikeda R, Fukuchi T, Kobayashi R, Sato C, Ogashiwa T, Inayama Y, Kunisaki R, Maeda S

Digestive Endoscopy Online Published 2023年4月

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DOI： 10.1111/den.14570

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Exploratory randomized phase II trial for optimizing treatment dosage and duration of adjuvant S‐1 plus oxaliplatin in patients with stage III colon cancer: YCOG1402 (SOAP trial) 査読

Yusuke Suwa, Jun Watanabe, Hirokazu Suwa, Mayumi Ozawa, Masashi Momiyama, Atsushi Ishibe, Kotaro Nagamine, Shigeru Yamagishi, Mitsuyoshi Ota, Tadao Fukushima, Hitoshi Sekido, Yusuke Saigusa, Itaru Endo

Annals of Gastroenterological Surgery 7 ( 6 ) 922 - 931 2023年4月

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掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

Abstract

Introduction

Conventionally, the recommended duration of adjuvant chemotherapy of colon cancer had been 6 months. The IDEA Collaboration suggested that shortening capecitabin and oxaliplatin (CAPOX) adjuvant chemotherapy may be possible. S‐1 and oxaliplatin (SOX) treatment is standard treatment in metastatic colorectal cancer in Japan. The aim of this study was to optimize treatment dosage and duration of adjuvant SOX in stage III colon cancer.

Methods

This trial was as open‐label multi‐center randomized phase II study. Patients with stage III colon cancer were randomly assigned to 3 months or 6 months of adjuvant SOX treatment in different doses: 130 mg/m<sup>2</sup> (3 months) or 100 mg/m<sup>2</sup> (6 months) of oxaliplatin. The primary endpoint was 3‐year disease‐free survival (DFS) and the null hypothesis for the primary endpoint was that the 3‐year DFS was ≤72% in each arm and was tested with a one‐sided significance level of 10%.

Results

Eighty‐two patients were assigned to the 6 months arm and 81 to the 3 months arm. The 3‐year DFS was 75.0% (80% CI 67.95–80.72, p = 0.282) in the 6 months arm and 76.9% (80% CI 70.1–82.38, p = 0.171) in the 3 months arm. Treatment completion rate and relative dose intensity (RDI) were higher in 3 months than 6 months arm. The adverse events (AE) were similar in both arms.

Conclusions

The 3‐year DFS was not significantly superior to null hypothesis in both 3 months and 6 months arms for the stage III colon cancer. Primary endpoint was not achieved. The SOX regimen was not feasible in long‐term outcomes.

DOI： 10.1002/ags3.12687

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Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia 査読

Hattori S, Suda A, Kishida I, Miyauchi M, Shiraishi Y, Noguchi N, Furuno T, Asami T, Fujibayashi M, Tsujita N, Ishii C, Ishii N, Saeki T, Fukushima T, Moritani T, Saigusa Y, Hishimoto A

BMC Psychiatry 23 135 2023年3月

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Development and validation of a survival nomogram and calculator for male patients with metastatic castration-resistant prostate cancer treated with abiraterone acetate and/or enzalutamide 査読

Kawahara T, Saigusa Y, Yoneyama S, Kato M, Kojima I, Yamada H, Kamihira O, Tabata K, Tsumura H, Iwamura M, Makiyama K, Uemura H, Miyoshi Y

BMC Cancer Accepted 2023年3月

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Serrated polyps in patients with ulcerative colitis: Unique clinicopathological and biologial characteristics 査読

Nishio M, Kunisaki R, Shibata W, Ajioka Y, Hirasawa K, Takase A, Chiba S, Inayama Y, Ueda W, Okawa K, Otake H, Ogashiwa T, Kinoshita H, Saigusa Y, Kimura H, Kato J, Maeda S

PLoS One 18 ( 2 ) e0282204 2023年2月

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生物多様性ビッグデータに基づいたネイチャーの可視化: その現状と展望査読

久保田康裕, 楠本聞太郎, 塩野貴之, 五十里翔吾, 深谷肇一, 高科直, 吉川友也, 重藤優太郎, 新保仁, 竹内彰一, 三枝祐輔, 小森理

計量生物学 43 ( 2 ) 145 - 188 2023年2月

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ILD-GAP combined with the Charlson Comorbidity Index score (ILD-GAPC) as a prognostic prediction model in patients with interstitial lung disease 査読

Fujii H, Hara Y, Saigusa Y, Tagami Y, Murohashi K, Nagasawa R, Aoki A, Izawa A, Seki K, Watanabe K, Horita N, Kobayashi N, Kaneko T

Canadian Respiratory Journal 2023 5088207 2023年2月

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Protocol for a confirmatory trial of the effectiveness and safety of palliative arterial embolization for painful bone metastases 査読

Zenda S, Arai Y, Sugawara S, Inaba Y, Hashimoto K, Yamamoto K, Saigusa Y, Kawaguchi T, Shimada S, Yokoyama M, Miyaji T, Okano T, Nakamura N, Kobayashi E, Takagi T, Matsumoto Y, Uchitomi Y, Sone M

BMC Cancer Accepted 2023年1月

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Ureteral stone volume and female gender predicts perioperative complications after complete ipsilateral upper urinary tract stone removal using flexible ureterorenoscopy 査読

Komeya M, Watanabe T, Odaka H, Kiuchi H, Saigusa Y, Makiyama K, Matsuzaki J

World Journal of Urology Accepted 2023年1月

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Appropriate Preconception Corticosteroid-free Remission Period in Pregnant Women with Ulcerative Colitis

Ikeda A, Kunisaki R, Aoki S, Yaguchi K, Madarame A, Nishio M, Ogashiwa T, Nakamori Y, Kimura H, Suzuki R, Saigusa Y, Maeda S

Inflammatory Bowel Diseases Accepted 2022年12月

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The psychological distress and suicide-related ideation in hospital workers during the COVID-19 pandemic: Second results from repeated cross-sectional surveys 査読

Ide K, Asami T, Suda A, Yoshimi A, Fujita J, Shiraishi Y, Nomoto M, Miyauchi M, Roppongi T, Furuno T, Watanabe K, Shimada T, Kaneko T, Saigusa Y, Kubota K, Kato H, Odawara T, Hishimoto A

PLoS One 17 ( 11 ) e0277174 2022年11月

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Comparison of clinical features between patients with acute exacerbation of idiopathic interstitial pneumonia and collagen vascular disease-associated interstitial pneumonia 査読

Kata Y, Hara Y, Murohashi K, Saigusa Y, Nagasawa R, Tagami Y, Fujii H, Aoki A, Nishikawa Y, Tanaka K, Watanabe K, Horita N, Kobayashi N, Yamamoto M, Kudo M, Kaneko T

Nagoya Journal of Medical Science Accepted 2022年11月

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Risks of malignancies among patients with psoriasis: A cohort study of 360 patients 査読

Watanabe T, Watanabe Y, Asai C, Asami M, Watanabe Y, Saigusa Y, Yamaguchi Y

The Journal of Dermatology Online Published 2022年11月

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DOI： 10.1111/1346-8138.16644

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Effectiveness of anger-focused emotional management training in reducing aggression among nurses 査読

Tanabe Y, Asami T, Yoshimi A, Abe K, Saigusa Y, Hayakawa M, Fujita J, Ide K, Suda A, Hishimoto A

Nursing Open Online published 2022年9月

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Hypotension after general anesthesia induction using remimazolam in geriatric patients: Protocol for a double-blind randomized controlled trial 査読

Yokose M, Takaki R, Mihara T, Saigusa Y, Yamamoto N, Masui K, Goto T

PLoS One 17 ( 9 ) e0275451 2022年9月

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Leukotriene Receptor Antagonist Therapy for the Chemoprevention of Human Rectal Aberrant Crypt Foci: Nonrandomized, Open-Label, Controlled Trial 査読

Higurashi T, Ashikari K, Tamura S, Saigusa Y, Takatsu T, Misawa N, Yoshihara T, Matsuura T, Fuyuki A, Ohkubo H, Kessoku T, Hosono K, Yoneda M, Nakajima A

Cancer Prevention Research Online published 2022年9月

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Changes in the number of babies born with Down syndrome in Japan 査読

Sugo Y, Kurasawa K, Saigusa Y, Hamanoue H, Hirahara F, Miyagi E

The Journal of Obstetrics and Gynaecology Research 48(9) 2385-2391 2022年9月

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Phase II study of a multi-center randomized controlled trial to evaluate oral Vitamin B12 treatment for Vitamin B12 deficiency after total gastrectomy in gastric cancer patients 査読

Aoyama T, Maezawa Y, Cho H, Saigusa Y, Tamura J, Tsuchida K, Komori K, Kano K, Segami K, Hara K, Senuki K, Suzuki Y, Yamakawa M, Tamagawa H, Oshima T, Yukawa N, Rino Y

Anticancer Research 42 ( 8 ) 3963 - 3970 2022年8月

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Chronological improvement in precision oncology implementation in Japan 査読

Sunami K, Naito Y, Komine K, Amano T, Ennishi D, Imai M, Kage H, Kanai M, Kenmotsu H, Koyama T, Maeda T, Morita S, Sakai D, Kohsaka S, Tsuchihara K, Saigusa Y, Yoshino T

Cancer Science Online published 2022年8月

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Assessment of diagnostic utility of serum hemeoxygenase-1 measurement for acute exacerbation of interstitial pneumonias 査読

Kata Y, Hara Y, Tagami Y, Yabe A, Murohashi K, Nagasawa R, Nakashima K, Fujii H, Saigusa Y, Shiida M, Watanabe K, Horita N, Kobayashi N, Kaneko T

Scientific reports 12 ( 1 ) 12935 2022年7月

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Impact of grip strength and gait speed on exercise tolerance in patients with pulmonary hypertension without left heart disease 査読

Okamura M, Konishi M, Saigusa Y, Ando S, Nakayama M, Komura N, Sugano T, Tamura K, Nakamura T

Heart and Vessels Online published 2022年5月

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Direct Comparison of US and MR Elastography for Staging Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease 査読

Imajo K, Honda Y, Kobayashi T, Nagai K, Ozaki A, Iwaki M, Kessoku T, Ogawa Y, Takahashi H, Saigusa Y, Yoneda M, Kirikoshi H, Utsunomiya D, Aishima S, Saito S, Nakajima A

Clinical Gastroenterology and Hepatology 20 908 - 917 2022年4月

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Effects of electrocardiographic monitoring education on nurses' confidence and psychological stress: an online cross-sectional survey in Japan 査読

Nishiguchi S, Sugaya N, Saigusa Y, Mayama M, Moromizato T, Inamori M, Tokuda Y, Watari T

International Journal of Environmental Research and Public Health 19:4742 2022年4月

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Problematic Internet use and daily difficulties among adolescents with school refusal behaviors: An observational cross-sectional analytical study 査読

Fujita J, Aoyama K, Saigusa Y, Miyazaki H, Aoki Y, Asanuma K, Takahashi Y, Hishimoto A

Medicine® Accepted 2022年2月

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Concurrent chemoradiotherapy with cisplatin + S-1 versus cisplatin + other third-generation agents for locally advanced non-small-cell lung cancer: a meta-analysis of individual participant data 査読

Taniguchi Y, Okamoto H, Shimokawa T, Sasaki T, Seto T, Niho S, Ohe Y, Saigusa Y

BMC Pulmonary Medicine 22 ( 1 ) 31 2022年1月

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MRI-based quantitative r2 * mapping at 3 tesla reflects hepatic iron overload and pathogenesis in nonalcoholic fatty liver disease patients 査読

Imajo K, Kessoku T, Honda Y, Hasegawa S, Tomeno W, Ogawa Y, Motosugi U, Saigusa Y, Yoneda M, Kirikoshi H, Yamanaka S, Utsunomiya D, Saito S, Nakajima A

Journal of Magnetic Resonance Imaging 55 ( 1 ) 111 - 125 2022年1月

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Gastroesophageal varices evaluation using spleen-dedicated stiffness measurement by vibration-controlled transient elastography 査読

Nagai K, Ogawa Y, Kobayashi T, Iwaki M, Nogami A, Honda Y, Kessoku T, Saigusa Y, Imajo K, Yoneda M, Kirikoshi H, Komatsu T, Saito S, Nakajima A

JGH Open 6 ( 1 ) 11 - 19 2022年1月

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Prognostic impact of HNF4α expression in interstitial lung disease 査読

Sawazumi T, Baba T, Iwasawa T, Arai H, Matsumura M, Takemura T, Sugiyama M, Sekiya M, Saigusa Y, Ogura T, Inayama Y, Ohashi K, Okudela K

Pathology international 72 ( 1 ) 25 - 34 2021年10月

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Two-dimensional index of departure from the symmetry model for square contingency tables with nominal categories 査読

Momozaki T, Nakagawa T, Ishii A, Saigusa Y, Tomizawa S

Symmetry 13 ( 11 ) 2031 2021年10月

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Association between suicidal behaviors and auditory and visual hallucinations in Japanese adolescent psychiatric outpatients at first visit: a cross-sectional study 査読国際誌

Toyohara N, Fujita J, Okumura Y, Suda A, Hattori S, Saigusa Y, Aoyama K, Asanuma K, Takahashi Y, Arai T, Hishimoto A

Child and Adolescent Mental Health Online published 2021年8月

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記述言語：英語

DOI： 10.1111/camh.12504

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Perinatal outcomes of recurrent placental abruption 査読

Kojima, T, Takami, M, Shindo, R, Saigusa, Y, Miyagi, E, Aoki, S

The Journal of Maternal-Fetal and Neonatal Medicine online published 2021年7月

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Evaluation of respiratory rate monitoring using a microwave Doppler sensor mounted on the ceiling of an intensive care unit: a prospective observational study 査読国際誌

Tanaka H, Yokose M, Takaki S, Mihara T, Saigusa Y, Goto T

Journal of Clinical Monitoring and Computing Online published 2021年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s10877-021-00733-w

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Potential benefits of minimally invasive laparoscopy in reducing local recurrence after surgery for low rectal cancer 査読国際誌

Numata M, Tamagawa H, Kazama K, Atsumi Y, Iguchi K, Sawazaki S, Aoyama T, Sato S, Sugano N, Godai T, Higuchi A, Saigusa Y, Saeki H, Yamada T, Oshima T, Shiozawa M, Yukawa N, Rino Y

Anticancer Research 41 ( 5 ) 2617 - 2623 2021年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.21873/anticanres.15042

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Effect of interventions in pregnant women with mildly impaired glucose tolerance 査読

Shindo R, Aoki S, Kasai J, Nakanishi S, Saigusa Y, Miyagi E

Journal of Obstetrics and Gynaecology Research 47 2021年4月

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Effect of coexisting advanced extrapulmonary solid cancer on progression of Mycobacterium avium complex lung disease 査読

Inoue R, Watanabe K, Saigusa Y, Hirama N, Hara Y, Kobayashi N, Kudo M, Kaneko T

Jornal Brasileiro de Pneumologia 47 ( 2 ) e20200520 2021年4月

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Effect of interprofessional collaboration among nursing home professionals on end-of-life care in nursing homes 査読

Nishiguchi S, Sugaya N, Saigusa Y, Inamori M

Drug Discoveries & Therapeutics 15 ( 2 ) 93 - 100 2021年4月

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An early screening tool for discharge planning shortened length of hospital stay for elderly patients with community-acquired pneumonia 査読国際誌

Chen H, Hara Y, Horita N, Saigusa Y, Kaneko T

Clinical Interventions in Aging 16 443 - 450 2021年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.2147/CIA.S296390

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Use of contrast-enhanced ultrasound with sonazoid for evaluating the radiotherapy efficacy for hepatocellular carcinoma 査読

Funaoka A, Numata K, Takeda A, Saigusa Y, Tsurugai Y, Nihonmatsu H, Chuma M, Fukuda H, Okada M, Nakano M, Maeda S

Diagnostics 11 2021年3月

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Does the Endoscopic Surgical Skill Qualification System improve patients’ outcome following laparoscopic surgery for colon cancer? A multicentre, retrospective analysis with propensity score matching 査読

Kazama K, Numata M, Aoyama T, Atsumi Y, Tamagawa H, Godai T, Saeki H, Saigusa Y, Shiozawa M, Yukawa N, Masuda M, Rino Y

World Journal of Surgical Oncology 19 2021年2月

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The psychological effects of COVID-19 on hospital workers at the beginning of the outbreak with a large disease cluster on the Diamond Princess cruise ship 査読国際誌

Ide K, Asami T, Suda A, Yoshimi A, Fujita J, Nomoto M, Roppongi T, Hino K, Takahashi Y, Watanabe K, Shimada T, Hamasaki T, Endo E, Kaneko T, Suzuki M, Kubota K, Saigusa Y, Kato H, Odawara T, Nakajima H, Takeuchi I, Goto T, Aihara M, Hishimoto A

PLoS One 16 ( 1 ) e0245294 2021年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1371/journal.pone.0245294

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Cardiovascular and renal outcomes with SGLT‑2 inhibitors versus GLP‑1 receptor agonists in patients with type 2 diabetes mellitus and chronic kidney disease: a systematic review and network meta‑analysis 査読

Yamada T, Wakabayashi M, Bhalla A, Chopra N, Miyashita H, Mikami T, Ueyama H, Fujisaki T, Saigusa Y, Yamaji T, Azushima K, Urate S, Suzuki T, Abe E, Wakui H, Tamura K

Cardiovascular Diabetology 20 2021年1月

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Additional Efficacy of Macrolide for Patients With Acute Deterioration of Interstitial Lung Disease Requiring Corticosteroid Pulse Therapy. 査読国際誌

Nagasawa R, Hara Y, Murohashi K, Saigusa Y, Nishikawa Y, Tanaka M, Aoki A, Tagami Y, Kobayashi N, Kudo M, Kaneko T

American Journal of Therapeutics Online Published 2021年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1097/MJT.0000000000001321

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High postoperative neutrophil–lymphocyte ratio and low preoperative lymphocyte-monocyte ratio predict poor prognosis in gastric cancer patients receiving gastrectomy with positive lavage cytology: a retrospective cohort study 査読

Sato S, Kunisaki C, Takahashi M, Kubo H, Tsuchiya N, Sato K, Miyamoto H, Tamura Y, Kondo H, Tanaka Y, Kasahara K, Kosaka T, Akiyama H, Saigusa Y, Endo I

Langenbeck's Archives of Surgery 406(7) 2021年1月

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Lateral lymph node dissection for mid-to-low rectal cancer: is it safe and effective in a practice-based cohort? 査読

Numata M, Tamagawa H, Kazama K, Kawahara S, Sawazaki S, Aoyama T, Maezawa Y, Kano K, Higuchi A, Godai T, Saigusa Y, Saeki H, Yukawa N, Rino Y

BMC Surgery 21 ( 1 ) 51 2021年1月

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Clinical utility of a composite scoring system including Charlson Comorbidity Index score in patients with interstitial lung disease 査読

Yagyu H, Murohashi K, Hara Y, Saigusa Y, Aoki A, Kobayashi N, Kaneko T

Journal of Thoracic Disease 12 2020年10月

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Safety and Efficacy of Lenvatinib Treatment in Child–Pugh A and B Patients with Unresectable Hepatocellular Carcinoma in Clinical Practice: A Multicenter Analysis 査読

Ogushi K, Chuma M, Uojima H, Hidaka H, Numata K, Kobayashi S, Hirose S, Hattori N, Fujikawa T, Nakazawa T, Wada N, Iwasaki S, Fukushima T, Sano Y, Ueno W, Kawano K, Tsuruya K, Shomura M, Watanabe T, Matsunaga K, Kunishi Y, Saigusa Y, Irie K, Iwabuchi S, Kako M, Morimoto M, Kagawa T, Tanaka K, Maeda S

Clinical and Experimental Gastroenterology 2020年10月

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Rationale and design of a randomised, double-blind, placebo-controlled, parallel-group, investigator-initiated phase 2a study to investigate the efficacy and safety of elobixibat in combination with cholestyramine for non-alcoholic fatty liver disease 査読国際誌

Kessoku T, Kobayashi T, Ozaki A, Iwaki M, Honda Y, Ogawa Y, Imajo K, Saigusa Y, Yamamoto K, Yamanaka T, Usuda H, Wada K, Yoneda M, Saito S, Nakajima A

BMJ Open 10 ( 9 ) e037961 2020年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) pathogenesis involves abnormal metabolism of cholesterol and hepatic accumulation of toxic free-cholesterol. Elobixibat (EXB) inhibits the ileal bile acid (BA) transporter. EXB and cholestyramine (CTM) facilitate the removal of free cholesterol from the liver by decreasing BA recirculation to the liver, thereby stimulating novel BA synthesis from cholesterol. In this randomised, double-blind, placebo-controlled, parallel-group, phase IIa study, we aim to provide a proof-of-concept assessment by evaluating the efficacy and safety of EXB in combination with CTM in patients with NAFLD. METHODS AND ANALYSIS: A total of 100 adult patients with NAFLD, diagnosed based on low-density lipoprotein cholesterol (LDL-C) level of >120 mg/dL and liver fat content of ≥8% by MRI-based proton density fat fraction (MRI-PDFF), who meet the inclusion/exclusion criteria will be enrolled. The patients will be randomly assigned to receive the combination therapy of 10 mg EXB and 9 g CTM powder (4 g CTM), 10 mg EXB monotherapy, 9 g CTM powder monotherapy or a placebo treatment (n=25 per group). Blood tests and MRIs will be performed 16 weeks following treatment initiation. The primary study endpoint will be the absolute LDL-C level change at week 16 after treatment initiation. The exploratory endpoint will include absolute changes in the liver fat fraction as measured by MRI-PDFF. This proof-of-concept study will determine whether the combination therapy of EXB and CTM is effective and safe for patients with NAFLD. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Ethics Committee of Yokohama City University Hospital before participant enrolment. The results of this study will be submitted for publication in international peer-reviewed journals and the key findings will be presented at international scientific conferences. TRIAL REGISTRATION NUMBER: NCT04235205.

DOI： 10.1136/bmjopen-2020-037961

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Efficacy and safety of colorectal endoscopic submucosal dissection in patients with sarcopenia 査読

Goto S, Arimoto J, Higurashi T, Takahashi K, Ohkubo N, Kawamura N, Tamura T, Tomonari H, Iwasaki A, Taniguchi L, Chiba H, Atsukawa K, Saigusa Y, Nakajima A

Surgical Endoscopy 35 2020年9月

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Lack of a bridge between screening and medical management for hypertension: health screening cohort in Japan 査読

Fukuma S, Ikenoue T, Saito Y, Yamada Y, Saigusa Y, Misumi T, Taguri M

BMC Public Health 20 2020年9月

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Declined functional status prolonged hospital stay for community-acquired pneumonia in seniors 査読国際誌

Chen H, Hara Y, Horita N, Saigusa Y, Hirai Y, Kaneko T

Clinical Interventions in Aging 15 1513 - 1519 2020年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Purpose: Among senior community-acquired pneumonia (CAP) survivors, functional status after hospitalization is often decreased. This study investigated the change of functional status affecting delayed discharge. Patients and Methods: This retrospective observational study was conducted in two medical facilities from January 2016 to December 2018. Hospitalized CAP patients >64 years old were divided into two groups: an early group discharged ≤1 week after ending antibiotic treatment and a delayed group discharged >1 week after ending antibiotic treatment. The primary outcome was decline in functional status. Results: The early group comprised 170 patients and the delayed group comprised 155 patients (median age: 78 vs 82 years; p = 0.007). Distribution of the causative microorganisms and initial prescription of antibiotics showed no significant differences in the two groups (p=0.38; p=0.83, respectively) More patients showed decline in functional status in the delayed group than the early group (16 (9.4%) vs 49 (31.6%), p<0.001), even if rehabilitation was more frequently conducted (77 (45.3%) vs 118 (76.1%); p<0.001). Higher medical expenses were observed in the delayed group ($8631 vs $3817, respectively; p<0.001). Multivariable regression analysis of factors contributing delayed discharge revealed that decreased functional status, pneumonia severity index (PSI) categories, rehabilitation enrolled, aspiration and age were independently associated with delayed discharge (odds ratio 4.31, 95% confidence interval (CI) 2.32-7.98; 2.34, 95% CI 1.43-3.82; 15.96, 95% CI 4.56-55.82 (PSI V vs II); 2.48, 95% CI 1.11-5.98; and 1.03, 95% CI 1.01-1.06; respectively). Conclusion: Functional status decline was independently associated with extended hospitalization.

DOI： 10.2147/CIA.S267349

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A method to obtain reproducible Ki-67 indexes in lung adenocarcinoma 査読

Okudela K, Woo T, Saigusa Y, Arai H, Matsumura M, Mitsui H, Sugiyama M, Sekiya M, Ishikawa Y, Oshiro H, Kameda Y, Ohashi K

Histopathology 78 2020年8月

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Laparoscopic vs. open surgery for stage II/III colon cancer patients with body mass index >25 kg/m2 査読

Kazama K, Numata M, Aoyama T, Onodera A, Hara K, Atsumi Y, Tamagawa H, Goda T, Saeki H, Saigusa Y, Okamoto H, Shiozawa M, Oshima T, Yukawa N, Masusa M, Rino Y

In Vivo 34 2020年7月

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Systematic review of the association between worsening renal function and mortality in patients with acute decompensated heart failure 査読

Yamada T, Ueyama H, Chopra N, Yamaji T, Azushima K, Kobayashi R, Kinguchi S, Urate S, Suzuki T, Abe E, Saigusa Y, Wakui H, Partridge P, Burger A, Bravo C A, Rodriguez M A, Ivey-Miranda J, Tamura K, Testani J, Coca S

Kidney International Reports 5 2020年7月

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In-hospital mortality in acute myocardial infarction according to population density and primary angioplasty procedures volume 査読

Matsuzawa Y, Konishi M, Nakai M, Saigusa Y, Taguri M, Gohbara M, Ebina T, Kosuge M, Hibi K, Nishimura K, Miyamoto Y, Yasuda S, Ogawa H, Saito Y, Nakayama N, Takeuchi I, Tamura K, Kimura K

Circulation journal : official journal of the Japanese Circulation Society 84 ( 7 ) 1140 - 1146 2020年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Low population density may be associated with high mortality in acute myocardial infarction (AMI) patients. The purpose of this study was to investigate the effect of population density and hospital primary percutaneous coronary intervention (PCI) volume on AMI in-hospital mortality in Japan.Methods and Results:This is a retrospective study of 64,414 AMI patients transported to hospital by ambulances. The main outcome measure was in-hospital mortality. The median population density was 1,147 (interquartile range, 342-5,210) persons/km2. There was a significant negative relationship between population density and in-hospital mortality (OR for a quartile down in population density 1.086, 95% CI 1.042-1.132, P<0.001). Patients in less densely populated areas were more often transported to hospitals with a lower primary PCI volume, and they had a longer distance to travel. By using multivariable analysis, primary PCI volume was found to be significantly associated with in-hospital mortality, but distance to hospital was not. When divided into the low- and high-volume hospitals, using the cut-off value of 115 annual primary PCI procedures, the increase in in-hospital mortality associated with low population density was observed only in patients hospitalized in the low-volume hospitals. CONCLUSIONS: Increased in-hospital mortality related to low population density was observed only in AMI patients who were transported to the low primary PCI volume hospitals, but not in those who were transported to high-volume hospitals.

DOI： 10.1253/circj.CJ-19-0869

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Low-density-lipoprotein apheresis-mediated endothelial activation therapy to severe-peripheral artery disease study: Rationale and study design 査読

Ueda E, Toya Y, Wakui H, Kawai Y, Azushima K, Fujita T, Saigusa Y, Yamanaka T, Yabuki Y, Mikami T, Goda M, Sugano T, Tamura K

Therapeutic Apheresis and Dialysis 24 2020年6月

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Randomized controlled trial of landiolol, a short‑acting beta‑1 adrenergic receptor blocker, illustrating changes in high‑molecular weight adiponectin levels after elective percutaneous coronary intervention 査読

Kiyokuni M, Konishi M, Saigusa Y, Iwata K, Nakayama N, Komura N, Sugano T, Ishigami T, Ishikawa T, Yamanaka T, Tamura K, Kimura K

Heart and Vessels 35 2020年6月

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The effects of pelvic incidence in the functional anatomy of the hip joint 査読

Ike H, Bodner R J, Lundergan W, Saigusa Y, Dorr L D

The Journal of Bone and Joint Surgery 102 2020年6月

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Metabolomic/lipidomic-based analysis of plasma to diagnose hepatocellular ballooning in patients with non-alcoholic fatty liver disease: A multicenter study 査読

Ogawa Y, Kobayashi T, Honda Y, Kessoku T, Tomeno W, Imajo K, Nakahara T, Oeda S, Nagaoki Y, Amano Y, Ando T, Hirayama M, Isono O, Kamiguchi H, Nagabukuro H, Ogawa S, Satomi Y, Saigusa Y, Takahashi H, Hyogo H, Yoneda M, Saito S, Yamanaka T, Aishima S, Eguchi Y, Kage M, Chayama K, Nakajima A

Hepatology Research 50 2020年5月

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Consistency of trans-abdominal and water-immersion ultrasound images of diseased intestinal segments in Crohn’s disease 査読

Wang F, Numata K, Yonezawa H, Sato K, Ishii Y, Yaguchi K, Kume N, Hashimoto Y, Nishio M, Nakamori Y, Ikeda A, Madarame A, Hirayama A, Ogashiwa T, Sasaki T, Jin M, Hanzawa A, Shibata N, Hashimorto S, Saigusa Y, Inayama Y, Maeda S, Kimura H, Kunisaki R

Diagnostics 10 2020年4月

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Have pregnancy outcomes improved with the introduction of the international association of diabetes and pregnancy study groups criteria in Japan? 査読

Nakanishi S, Aoki S, Kasai J, Shindo R, Saigusa Y, Miyagi E

Journal of Diabetes Investigation 11 2020年3月

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掲載種別：研究論文（学術雑誌）

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Clinical impact of evaluation of frailty in endoscopic submucosal dissection for early gastric cancer in elderly patients 査読

Misawa N, Higurashi T, Tachikawa J, Tanabe H, Yoshihara T, Ashikari K, Kanoshima K, Fuyuki A, Ohkubo H, Saigusa Y, Chiba H, Nonaka T, Kuriyama H, Kobayashi N, Nakajima A

Geriatrics and Gerontology International 20 2020年3月

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The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine 査読国際誌

Hattori S, Suda A, Miyauchi M, Shiraishi Y, Saeki T, Fukushima T, Fujibayashi M, Tsujita N, Ishii C, Ishii N, Moritani T, Saigusa Y, Kishida I

BMC psychiatry 20 ( 1 ) 72 - 72 2020年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Use of the antipsychotic drug olanzapine by patients with schizophrenia is associated with autonomic nervous system (ANS) dysfunction. It is presumed that there are interindividual differences in ANS dysfunction that correspond to pharmacogenetics. In this study, we investigated whether genetic polymorphisms in ABCB1, CYP1A2, and UGT1A4 are associated with this observed ANS dysfunction. METHODS: A total of 91 schizophrenia patients treated with olanzapine monotherapy participated in this study. A power spectral analysis of heart rate variability was used to assess ANS activity. The TaqMan system was used to genotype seven single nucleotide polymorphisms (SNPs) in CYP1A2 (rs2069514 and rs762551), UGT1A4 (rs2011425), and ABCB1 (rs1045642, rs1128503, rs2032582, rs2235048). RESULTS: Sympathetic nervous activity was significantly higher in individuals with the UGT1A4 rs2011425 G allele than in those with the UGT1A4 rs2011425 non-G allele (sympathetic activity, p = .001). Furthermore, sympathetic nervous activity was also significantly associated with UGT1A4 rs2011425 genotype as revealed by multiple regression analysis (sympathetic activity, p = .008). CONCLUSIONS: We suggest that the UGT1A4 rs2011425 polymorphism affects olanzapine tolerability because it is associated with the observed side effects of olanzapine in schizophrenia patients, namely sympathetic dysfunction.

DOI： 10.1186/s12888-020-02492-5

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Impact of introducing the international association of diabetes and pregnancy study groups (IADPSG) criteria on pregnancy outcomes in Japan 査読

Shindo R, Aoki S, Kasai J, Saigusa Y, Nakanishi S, Miyagi E

Endocrine Journal 67 ( 1 ) 15 - 20 2020年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

To estimate pregnancy complications in women newly diagnosed with gestational diabetes mellitus (GDM) according to the new International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria and verify the validity of introducing the IADPSG criteria in Japan. This retrospective study included data from women with singleton delivery at 22 weeks or later at a tertiary hospital during 2000-2009. We compared pregnancy outcomes between women who would now be diagnosed with GDM according to the IADPSG criteria but not by the old JSOG criteria (IGT group, n = 503) and women with normal glucose tolerance according to both the criteria (NGT group, n = 2,789). Multivariate analysis was performed and adjusted for background factors. Maternal age at delivery and pre-pregnancy BMI were significantly higher in the IGT group than in the NGT group, while gestational weeks at delivery did not differ between the groups. No difference was observed in the rates of GDM-related composite complications (defined as cases with at least one of the following: macrosomia, shoulder dystocia, neonatal hypoglycemia, neonatal hyperbilirubinemia, or neonatal respiratory distress syndrome) at 11.9% and 8.8% (adjusted odds ratio (OR) 1.30, 95% confidence interval (CI) 0.90-1.87, p = 0.16). Pregnancy outcomes did not differ significantly between the IGT and NGT groups, except for frequencies of total neonatal admissions at 10.5% and 7.1%, respectively (adjusted OR 1.55, 95% CI 1.12-2.13, p < 0.01).

DOI： 10.1507/endocrj.EJ19-0279

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Efficacy and safety of enoxaparin for preventing venous thromboembolic events after laparoscopic colorectal cancer surgery: a randomized‑controlled trial (YCOG 1404) 査読

Nakagawa, K, Watanabe, J, Ota, M, Suwa, Y, Suzuki, S, Suwa, H, Momiyama, M, Ishibe, A, Saigusa, Y, Yamanaka, T, Kunisaki, C, Endo, I

Surgery Today 50 2020年1月

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Sampling bias correction in species distribution models by quasi-linear Poisson point process 査読

Komori O, Eguchi S, Saigusa Y, Kusumoto B, Kubota Y

Ecological Informatics 55 101015 2020年1月

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掲載種別：研究論文（学術雑誌）

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Risk factors for Chlamydia trachomatis infection and preterm birth in pregnant Japanese women: Does chlamydial infection cause preterm birth? 査読

Cho T, Aoki S, Saigusa Y, Shindo R, Obata S, Kasai M, Enomoto K, Miyagi E

73 2020年1月

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掲載種別：研究論文（学術雑誌）

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MiR-194-5p in pancreatic ductal adenocarcinoma peritoneal washings is associated with peritoneal recurrence and overall survival in peritoneal cytology-negative patients 査読

Kubo H, Hiroshima Y, Mori R, Saigusa Y, Murakami T, Yabushita Y, Sawada Y, Homma Y, Kumamoto T, Matsuyama R, Endo I

Annals of Surgical Oncology 26 4506 - 4514 2019年12月

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掲載種別：研究論文（学術雑誌）

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Quasi point-symmetry models based on f-divergence and decomposition of point-symmetry for multi-way contingency tables 査読

Yoshimoto, T, Tahata, K, Saigusa, Y, Tomizawa, S

SUT Journal of MAthematics 55 ( 2 ) 103 - 131 2019年12月

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掲載種別：研究論文（学術雑誌）

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Remission induction, maintenance, and endoscopic outcome with oral 5-aminosalicylic acid in intestinal Behcet's disease 査読

Kinoshita, H, Nishioka, H, Ikeda, A, Ikoma, K, Sameshima, Y, Ohi, H, Tatsuno, M, Kouyama, J, Kawamoto, C, Mitsui, T, Tamura, Y, Hashimoto, Y, Nishio, M, Ogashiwa, T, Saigusa, Y, Maeda, S, Kimura, H, Kunisaki, R, Koike, K

Journal of Gastroenterology and Hepatology 34 2019年11月

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Development and internal validation of a nomogram to predict perioperative complications after flexible ureteroscopy for renal stones in overnight ureteral catheterization cases 査読

Komeya M, Odaka H, Asano J, Asai T, Saigusa Y, Ogawa T, Yao M, Matsuzaki J

World Journal of Urology 38 2019年11月

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掲載種別：研究論文（学術雑誌）

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Nudging patients with chronic kidney disease at screening to visit physicians: A protocol of a pragmatic randomized controlled trial. 査読国際誌

Fukuma S, Ikenoue T, Sasaki S, Saigusa Y, Misumi T, Saito Y, Yamada Y, Goto R, Taguri M

Contemporary Clinical Trials Communications 16 2019年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）

Background/Aims: Strategies for an effective intervention after chronic kidney disease (CKD) screening have not been well examined. We describe the rationale and design of a protocol of a pragmatic randomized controlled trial (RCT) to test the effect of a behavioral intervention using the nudge approach in behavioral economics on CKD patients' visiting behaviors to physicians and change in their kidney function after CKD screening. Methods: The RCT will include CKD patients (N = 4500) detected at screening (estimated glomerular filtration rate [eGFR] <60 mL/min/1.74 m2 or urine protein ≥1+), aged 40-63 years. The two intervention groups will receive a "usual letter" and "nudge-based letter," while the control group will only receive a conventional follow-up. Our primary outcome is proportion of patients' visiting physicians for 6 months after the intervention; the secondary outcome is change in the eGFR at 2 years after the intervention. Results: We developed an efficient intervention program after CKD screening and designed the pragmatic RCT to assess its effectiveness in the real world. Our trial is unique in that it investigates the effect of the nudge approach in behavioral economics. By the end of 2018, we have enrolled 1,692 participants, and randomized 677 participants into the usual letter group, 677 participants into the nudge-based letter group, and 338 participants into the control group. We have confirmed that health checkup data could identify a large number of eligible participants. Conclusion: The trial's results will contribute to filling in the gap between screening and subsequent medical interventions for preventing CKD progression.

DOI： 10.1016/j.conctc.2019.100429

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Stereotactic body radiotherapy for primary non-small cell lung cancer patients with clinical T3-4N0M0 (UICC 8th edition): outcomes and patterns of failure 査読

Narita A, Takeda A, Eriguchi T, Saigusa Y, Sanuki N, Tsurugai Y, Enomoto T, Kuribayashi H, Mizuno T, Yashiro K, Hara Y, Kaneko T

Journal of Radiation Research 60 ( 5 ) 639 - 649 2019年7月

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掲載種別：研究論文（学術雑誌）

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A return to work program improves parasympathetic activity and psychiatric symptoms in workers on sick leave due to depression 査読

Hattori, S, Kishida, I, Suda, A, Kawanishi, C, Miyauchi, M, Shiraishi, Y, Fujibayashi, M, Tsujita, N, Ishii, C, Moritani, T, Saigusa, Y, Hirayasu, Y

Heliyon 5 e02151 2019年7月

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The perfusion index measured by the pulse oximeter affects the agreement between ClearSight and the arterial catheter-based blood pressures: A prospective observational study 査読

Yokose, M, Mihara, T, Takaya, M, Yamamoto, T, Saigusa, Y, Takaki, S, Goto, T

PLoS One 14 e0219511 2019年7月

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Tumor volume index as a prognostic factor in patients after curative esophageal cancer resection 査読国際誌

Miyamoto, H, Kunisaki, C, Sato, S, Tanaka, Y, Sato, K, Kosaka, T, Yukawa, N, Akiyama, H, Saigusa, Y, Endo, I

Annals of Surgical Oncology 26 ( 6 ) 1909 - 1915 2019年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1245/s10434-019-07308-9

PubMed

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Clinical significance of Charlson comorbidity index as a prognostic parameter for patients with acute or subacute idiopathic interstitial pneumonias and acute exacerbation of collagen vascular diseases-related interstitial pneumonia 査読

Murohashi, K, Hara, Y, Saigusa, Y, Kobayashi, N, Sato, T, Yamamoto, M, Kubo, M, Kaneko, T

Journal of Thoracic Disease 11 2448 - 2457 2019年6月

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Dose pre-eclampsia without proteinuria lead to different pregnancy outcomes than pre-eclampsia with proteinuria? 査読

Tochio, A, Obata, S, Saigusa, Y, Shindo, R, Miyagi, E, Aoki, S

The Journal of Obstetrics and Gynaecology Research 45 2019年5月

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D3 lymph node dissection reduces recurrence after primary resection for elderly patients with colon cancer 査読

Numata, M, Sawazaki, S, Aoyama, T, Tamagawa, H, Sato, T, Saeki, H, Saigusa, Y, Taguri, M, Mushiake, H, Oshima, T, Yukawa, N, Shiozawa, M, Rino, Y, Masuda, M

International Journal of Colorectal Disease 34 621 - 628 2019年4月

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Randomized phase II trial of the prophylactic use of celecoxib for the prevention of oxaliplatin-related peripheral vascular pain in Capeox (YCOG1205) 査読国際誌

Suwa, Y, Watanabe, J, Ota, M, Suzuki, S, Suwa, H, Watanabe, K, Saito, S, Nagamine, K, Momiyama, M, Ishibe, A, Saigusa, Y, Yamanaka, T, Endo, I

Cancer Chemotherapy and Pharmacology 83 ( 3 ) 419 - 424 2019年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1007/s00280-018-3739-9

PubMed

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Adverse pregnancy outcomes related to preterm cesarean delivery 査読国際誌

Kino, T, Yamamoto, Y, Saigusa, Y, Aoki, S, Miyagi, E

European Journal of Obstetrics and Gynecology and Reproductive Biology 234 89 - 91 2019年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.ejogrb.2018.12.033

PubMed

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Laparoscopic surgery in patients diagnosed with clinical N2 colon cancer 査読

Numata, M, Sawazaki, S, Aoyama, T, Tamagawa, H, Godai, T, Sato, T, Saeki, H, Saigusa, Y, Taguri, M, Mushiake, H, Oshima, T, Yukawa, N, Shiozawa, M, Masuda, M, Rino, Y

Surgery Today 49 507 - 512 2019年1月

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Measure of departure from local symmetry for square contingency tables 査読

Saigusa, Y, Takami, M, Ishii, A, Tomizawa, S

International Journal of Statistics and Probability 8 140 - 145 2019年

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担当区分：筆頭著者,　責任著者

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A Phase II Study of Tri-weekly Low-dose Nab-paclitaxel Chemotherapy for Patients with Advanced Gastric Cancer 査読国際誌

Sato S, Kunisaki C, Tanaka Y, Sato K, Miyamoto H, Yukawa N, Fujii Y, Kimura J, Takagawa R, Takahashi M, Kosaka T, Akiyama H, Saigusa Y, Taguri M, Yamanaka T, Endo I.

Anticancer Research 38 ( 12 ) 6911 - 6917 2018年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND/AIM: Nanoparticle albumin-bound (nab)-paclitaxel has demonstrated antitumor activity against advanced gastric cancer. However, gastric cancer patients can be difficult to treat with the recommended dose because of the high incidence of adverse toxicities. The aim of this study was to evaluate the safety and effectiveness of low-dose nab-paclitaxel in a multicenter, single-arm, phase II study. PATIENTS AND METHODS: Treatment included low doses of 180 mg/m2 nab-paclitaxel administered on day 1 of each 21-day cycle. The primary endpoint was defined as the overall response rate (ORR). The secondary endpoints included progression-free survival (PFS), safety, and overall survival (OS). A total of 34 patients were enrolled in the full-analysis set. RESULTS: The ORR was 5.9%. The median PFS and OS were 2.4 months and 9.2 months, respectively. The most common grade 3/4 toxicities were anemia (8.8%), neutropenia (5.9%), appetite loss (5.9%) and peripheral sensory neuropathy (5.9%). No treatment-related deaths occurred. CONCLUSION: The tri-weekly low dose of nab-paclitaxel therapy is effective towards advanced gastric cancer patients with good tolerability and an acceptable margin of safety.

DOI： 10.21873/anticanres.13068

PubMed

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Surgical outcomes of reduced-port laparoscopic gastrectomy versus conventional laparoscopic gastrectomy for gastric cancer: a propensity-matched retrospective cohort study 査読

Kunisaki, C, Miyamoto, H, Sato, S, Tanaka, Y, Sato, K, Izumisawa, Y, Yukawa, N, Kosaka, T, Akiyama, H, Saigusa, Y, Sakamaki, K, Yamanaka, T, Endo, I

Annals Of Surgical Oncology 25 3604 - 3612 2018年11月

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Association between dysfunction of autonomic nervous system activity and mortality in schizophrenia 査読国際誌

Hattori, S, Suda, A, Kishida, I, Miyauchi, M, Shiraishi, Y, Fujibayashi, M, Tsujita, N, Ishii, C, Ishii, N, Moritani, T, Saigusa, Y, Hirayasua, Y

Comprehensive Psychiatry 86 119 - 122 2018年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.comppsych.2018.08.002

PubMed

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Short- and long-term efficacy of adalimumab salvage therapy after failure of calcineurin inhibitors in steroid-refractory ulcerative colitis 査読

Nishio, M, Ishii, Y, Hashimoto, Y, Otake, H, Ogashiwa, T, Tsuda, S, Yasuhara, H, Saigusa, Y, Kimura, H, Maeda, S, Kunisaki, R

Scandinavian Journal of Gastroenterology 53 2018年10月

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Extended marginal homogeneity model based on complementary log-log transform for square tables 査読

Saigusa, Y, Maruyama, T, Tahata, K, Tomizawa, S

International Journal of Statistics and Probability 7 27 - 31 2018年5月

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担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

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Unrestricted normal distribution type symmetry model for square contingency tables with ordered categories 査読

Saigusa, Y, Goda, S, Yamamoto, K, Tomizawa, S

Journal of Biometrics and Biostatistics 9 2018年3月

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担当区分：筆頭著者,　責任著者

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Should the IADPSG criteria be applied when diagnosing early-onset gestational diabetes? 査読

Hagiwara, Y, Kasai, J, Nakanishi, S, Saigusa, Y, Miyagi, E, Aoki, S

Diabetes Research and Clinical Practice 140 154 - 161 2018年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

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Decomposition of point-symmetry using ordinal quasi point-symmetry for ordinal multi-way tables 査読

Saigusa, Y, Tahata, K, Tomizawa, S

Open Journal of Statistics 6 381 - 386 2016年

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担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

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A measure of departure from second-order marginal symmetry for multi-way tables with nominal categories 査読

Saigusa, Y, Tahata, K, Tomizawa, S

SUT Journal of Mathematics 52 1 - 19 2016年

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担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

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▼全件表示

書籍等出版物

野生生物の生息適地と分布モデリング―Rプログラムによる実践―

Antoine Guisan, Wilfried Thuiller, Niklaus E. Zimmermann, (著), 久保田康裕, (監訳,訳), 楠本聞太郎, 小森理, 三枝祐輔, 佐藤恵里, 塩野貴之, 鈴木智之, 須藤健二, 田中崇行, 比嘉基紀, 深谷肇一, 藤沼潤一, (訳)

共立出版 2020年2月

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講演・口頭発表等

正方分割表における部分対称と部分非対称からの隔たりを測るベクトル型尺度

桃崎智隆, 中川智之, 石井晶, 三枝祐輔, 富澤貞男

日本分類学会 2019年12月

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会議種別：口頭発表（一般）

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正方分割表における部分対称性に関する種々のモデルとその尺度

桃崎智隆, 福本伸樹, 中川智之, 石井晶, 三枝祐輔, 富澤貞男

科学研究費シンポジウム「統計的推測および確率解析に関する総合的研究」 2019年12月

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会議種別：口頭発表（一般）

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Generalized mixed model with non-normal density

Saigusa Y, Komori O, Eguchi S

The 12th International Conference of the ERCIM WG on Computational and Methodological Statistics 2019年12月

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会議種別：ポスター発表

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正方分割表における累積確率に基づく対称性の幾何平均型尺度

矢野大貴, 三枝祐輔, 石井晶, 富澤貞男

日本計算機統計学会 2019年11月

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会議種別：口頭発表（一般）

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一般化平均を用いた非正規な混合効果モデル

三枝祐輔, 小森理, 江口真透

統計関連学会連合大会 2019年9月

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正方分割表における条件付き部分対称モデルからの隔たりを測る尺度

福本伸樹, 三枝祐輔, 中川智之, 富澤貞男

統計関連学会連合大会 2019年9月

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Vector measure of departure from partial symmetry-asymmetry for square contingency tables

桃崎智隆, 富澤貞男, 三枝祐輔, 石井晶, 中川智之

統計関連学会連合大会 2019年9月

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Long-term mortality and characteristics among patients taking one of four direct oral anti coagulants or Warfarin for atrial fibrillation: A 5-year nationwide cohort study in Japan

Kuwabara M, Hamano T, Iimuro S, Yoshimura K, Takguri M, Kubota K, Hanafusa N, Saigusa Y, Yamamoto K, Misumi T

European Society of Cardiology (ESC) Congress 2022 2022年8月

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Simultaneous evaluation of superiority and non-inferiority for sensitivity and specificity

Hara M, Saigusa Y, Shinoda S, Yamamoto K

43rd Annual Conference of the International Society for Clinical Biostatistics 2022年8月

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会議種別：ポスター発表

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確定診断が存在しない疾患に対する検査の評価方法

田村惇, 三枝祐輔, 山本紘司

かごしまデータ科学シンポジウム 2022年7月

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Impact of Learning Program on Treatment Recommendations by Molecular Tumor Boards and an Artificial Intelligence based Annotation System: A Prospective Study

Sunami K, Naito Y, Amano T, Ennishi D, Imai M, Kage H, Kanai M, Kenmotsu H, Komine K, Koyama T, Maeda T, Morita S, Saigusa Y, Sakai D, Kinoshita I, Kozuki T, Sakashita H, Kohsaka S, Tsuchihara K, Yoshino T

58th Annual Meeting of the American Society of Clinical Oncology (ASCO) 2022年6月

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会議種別：ポスター発表

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潜在クラスモデルを用いたF1スコアによる検査法の性能比較

田村惇, 三枝祐輔, 山本紘司

日本計算機統計学会 2022年5月

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A Bayesian method for comparing F1 scores in the absence of a Gold Standard

田村惇, 三枝祐輔, 山本紘司

日本分類学会 2021年12月

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Chronological improvement in precision oncology implementation in Japan

Komine K, Sunami K, Naito Y, Amano T, Ennishi D, Imai M, Kage H, Kanai M, Kenmotsu H, Koyama T, Maeda T, Morita S, Sakai D, Kohsaka S, Tsuchihara K, Saigusa Y, Yamanaka T, Yoshino T

European Society for Medical Oncology (ESMO) Congress 2021 2021年9月

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会議種別：ポスター発表

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Concordance analysis of treatment recommendations between central consensus and multidisciplinary tumor boards

Kage H, Sunami K, Naito Y, Amano T, Ennishi D, Ennishi D, Imai M, Kanai M, Hirotsugu H, Kenmotsu K, Komine K, Koyama T, Sachi TM, Morita M, Saigusa Y, Sakai D, Takeharu T, Yamanaka Y, Kohsaka S, Tsuchihara K, Yoshino T

European Society for Medical Oncology (ESMO) Congress 2021 2021年9月

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Japanese Society of Medical Oncology/Health Authority of the Japanese Government Cooperative Virtual Educational Program for Improving the Clinical Annotation for Cancer Genomic Medicine

Amano T, Sunami K, Naitio Y, Ennishi D, Imai M, Kage H, Kanai M, Kenmotsu H, Komine K, Koyama T, Sachi TM, Morita M, Saigusa Y, Sakai D, Kinoshita I, Kozuki T, Sakashita H, Kohsaka S, Tsuchihara K, Yoshino T

European Society for Medical Oncology (ESMO) Congress 2021 2021年9月

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会議種別：ポスター発表

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横浜市における救急出場件数に対する関数動的予測モデリング

三角俊裕, 三枝祐輔, 原みゆひ, 山中竹春, 藤田豊, 古場亮介

統計関連学会連合大会 2021年9月

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Species distribution modeling using geometric-mean divergence

Osamu Komori, Yusuke Saigusa, Shinto Eguchi

The 12th conference of the Asian Regional Section of the International Association for Statistical Computing 2023年12月

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Enhancing the robustness of Bayesian optimal dose design in phase I/II clinical trials

Zhao Shiqi, Yusuke Saigusa, Kouji Yamamoto

かごしまデータ科学シンポジウム 2023年12月

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Robust estimation for thinned Poisson point process 招待

三枝祐輔, 小森理, 江口真透

統計関連学会連合大会 2023年9月

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Geometric-mean divergenceに基づく生物多様性予測招待

小森理, 三枝祐輔, 江口真透

統計関連学会連合大会 2023年9月

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A simultaneous evaluation of superiority and non‐Inferiority for comparing screening tests

Miyu Kobayashi, Satoru Shinoda, Yusuke Saigusa, Kouji Yamamoto

44th Annual Conference of the International Society for Clinical Biostatistics 2023年8月

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会議種別：ポスター発表

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スクリーニング検査の性能評価における優越性および非劣性検定を組み合わせた新たな解析手法

小林実結, 篠田覚, 三枝祐輔, 山本紘司

応用統計学会 2023年4月

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会議種別：ポスター発表

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A Bayesian dose-finding design for the optimal doses under a mislabel model in Phase I/II clinical trials

Shiqi Zhao, 三枝祐輔, 山本紘司

日本計量生物学会 2023年4月

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新たなスクリーニング検査の追加に対する診断性能評価

小林実結, 篠田覚, 三枝祐輔, 山本紘司

日本計算機統計学会 2022年11月

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会議種別：口頭発表（一般）

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生態学におけるポアソン点過程モデルのロバスト推定

三枝祐輔, 小森理, 江口真透

統計関連学会連合大会 2022年9月

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会議種別：口頭発表（一般）

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区間打ち切りを考慮したランダム化選択デザインの検討

西川智美, 三枝祐輔, 山本紘司

統計関連学会連合大会 2022年9月

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会議種別：口頭発表（一般）

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分割表における種々の対称モデルに関する尺度

桃崎智隆, 斎藤健, 三枝祐輔, 生亀清貴, 中川智之, 石井晶, 富澤貞男

科学研究費シンポジウム「多様な高次元モデルにおける理論と方法論，及び，関連分野への応用」 2020年2月

　詳細を見る

会議種別：口頭発表（一般）

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正方分割表におけるf-ダイバージェンスに基づく順序準対称モデルを用いた対称性の分解について

三枝祐輔

統計数理研究所共同研究集会統計サマーセミナー 2015年8月

　詳細を見る

会議種別：口頭発表（一般）

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Orthogonal decompositions of symmetry using models based on f-divergence for square contingency tables

三枝祐輔, 田畑耕治, 富澤貞男

西東京統計研究会 2015年3月

　詳細を見る

会議種別：口頭発表（一般）

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Decompositions of symmetry using models based on f-divergence for square contingency tables

三枝祐輔, 田畑耕治, 富澤貞男

科学研究費シンポジウム「多様な分野における統計科学の教育・理論・応用の新展開」 2014年10月

　詳細を見る

会議種別：口頭発表（一般）

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正方分割表におけるf-ダイバージェンスに基づく順序準対称モデルを用いた対称性の分解

三枝祐輔, 田畑耕治, 富澤貞男

統計関連学会連合大会 2014年9月

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会議種別：口頭発表（一般）

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正方分割表におけるf-ダイバージェンスに基づく準対称モデルを用いた対称性の分解について

三枝祐輔, 田畑耕治, 富澤貞

応用統計学会 2014年5月

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会議種別：ポスター発表

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正方分割表における拡張パリンドロミック対称モデルを用いた対称性の分解

三枝祐輔, 田畑耕治, 富澤貞男

日本統計学会 2014年3月

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会議種別：ポスター発表

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正方分割表における拡張パリンドロミック対称モデルと対称性の分解

三枝祐輔, 田畑耕治, 富澤貞男

科学研究費シンポジウム「統計科学の新展開」 2013年11月

　詳細を見る

会議種別：口頭発表（一般）

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Decomposition of symmetry using extended palindromic symmetry models for square contingency tables

三枝祐輔, 田畑耕治, 富澤貞男

日本数学会 2013年9月

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会議種別：口頭発表（一般）

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順序カテゴリ正方分割表における拡張パリンドロミック対称モデル

三枝祐輔, 田畑耕治, 富澤貞男

応用統計学会 2013年5月

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会議種別：ポスター発表

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Extended palindromic symmetry models for square contingency tables with ordered categories

三枝祐輔, 田畑耕治, 富澤貞男

日本数学会 2013年3月

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会議種別：口頭発表（一般）

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多元分割表における二次周辺対称性の尺度

三枝祐輔

統計数理研究所共同研究集会統計サマーセミナー 2016年8月

　詳細を見る

会議種別：口頭発表（一般）

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On measure of second-order marginal symmetry for multi-way contingency tables 国際会議

Saigusa, Y

The 4th Institute of Mathematical Statistics Asia Pacific Rim Meeting 2016年6月

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会議種別：口頭発表（一般）

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On measure of second-order marginal symmetry for multi-way classifications

三枝祐輔, 田畑耕治, 富澤貞男

日本計算機統計学会 2016年5月

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会議種別：口頭発表（一般）

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ゾーン間のパスを用いたJ1チームの分類

丸山智久, 三枝祐輔, 田畑耕治

日本統計学会 2016年3月

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会議種別：ポスター発表

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Decompositions of symmetry using extended ordinal quasi-symmetry model for two-way contingency tables

三枝祐輔

日本統計学会 2016年3月

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会議種別：ポスター発表

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３元分割表における対称性の尺度

三枝祐輔

応用統計学会 2016年3月

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会議種別：ポスター発表

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A measure of departure from second-order marginal symmetry for multi-way contingency tables

三枝祐輔, 田畑耕治, 富澤貞男

日本数学会 2016年3月

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会議種別：口頭発表（一般）

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ゾーン間におけるパスを用いたJ1チームの特徴の比較

丸山智久, 三枝祐輔, 田畑耕治

日本統計学会スポーツ統計分科会 2015年12月

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会議種別：口頭発表（一般）

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On decompositions of symmetry for square contingency tables 国際会議

Saigusa, Y, Tahata, K, Tomizawa, S

QBIC Workshop 2015 2015年10月

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会議種別：口頭発表（一般）

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多元分割表における二次周辺対称性からの隔たりを測る尺度

三枝祐輔, 田畑耕治, 富澤貞男

統計関連学会連合大会 2015年9月

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会議種別：口頭発表（一般）

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二元分割表における独立性および対称性に関するモデルと分解

佐藤駿, 合田新平, 三枝祐輔, 生亀清貴, 山本紘司

科学研究費シンポジウム「多様な分野における統計科学の総合的研究」 2017年11月

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会議種別：口頭発表（一般）

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準線形モデルによるポアソン点過程の拡張とその応用

小森理, 三枝祐輔, 江口真透

科学研究費シンポジウム「統計学, 機械学習の数理とその応用」 2017年9月

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会議種別：口頭発表（一般）

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生態デ－タのためのポアソン点過程モデル -準線形モデリング-

小森理, 三枝祐輔, 江口真透

統計関連学会連合大会 2017年9月

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会議種別：口頭発表（一般）

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A measure of departure from partial marginal homogeneity for square contingency tables

久保裕太郎, 三枝祐輔, 田畑耕治, 富澤貞男

日本数学会 2017年3月

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会議種別：口頭発表（一般）

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Decomposition of marginal homogeneity using model based on complementary log-log transform for square contingency tables

丸山智久, 三枝祐輔, 田畑耕治, 富澤貞男

日本数学会 2017年3月

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会議種別：口頭発表（一般）

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正方分割表における部分対称性の尺度

三枝祐輔, 田畑耕治, 富澤貞男

応用統計学会 2017年3月

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会議種別：ポスター発表

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On measure of departure from extended marginal homogeneity for square tables with ordinal categories

鈴木惇一, 三枝祐輔, 田畑耕治, 富澤貞男

西東京統計研究会 2017年3月

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会議種別：口頭発表（一般）

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正方分割表における補対数対数変換にもとづく周辺非同等モデル

丸山智久, 三枝祐輔, 田畑耕治, 富澤貞男

日本計算機統計学会 2016年11月

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会議種別：口頭発表（一般）

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順序カテゴリ正方分割表における拡張周辺同等性からの隔たりの尺度

鈴木惇一, 三枝祐輔, 田畑耕治, 富澤貞男

日本計算機統計学会 2016年9月

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会議種別：口頭発表（一般）

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多元分割表における線形準点対称モデルと点対称性の分解

三枝祐輔, 田畑耕治, 富澤貞男

日本数学会 2016年9月

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会議種別：口頭発表（一般）

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正方分割表における部分対称性に関するベクトル型尺度

桃崎智隆, 中川智之, 石井晶, 三枝祐輔, 富澤貞男

応用統計学会 2019年5月

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Two kinds of measures of departure from partial symmetry for square contingency tables

三枝祐輔, 石井晶, 中川智之, 富澤貞男

応用統計学会 2019年5月

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正方分割表における局所対称性とその尺度の提案

高見光広, 三枝祐輔, 石井晶, 富澤貞男

日本統計学会 2019年3月

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順序カテゴリの正方分割表における対称性に関する幾何平均型尺度

高見光広, 三枝祐輔, 石井晶, 中川智之, 富澤貞男

日本数学会 2019年3月

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救急需要予測のための時空間正規混合モデル：横浜市救急データへの応用

三枝祐輔, 三角俊裕, 窪田和巳, 山中竹春, 藤田豊, 金子由佳

科学研究費シンポジウム「予測モデリングとその周辺 -機械学習・統計科学・情報理論からのアプローチ-」 2018年11月

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時空間統計モデルを用いた横浜市における救急出場件数の予測

三枝祐輔, 三角俊裕, 窪田和巳, 山中竹春, 藤田豊, 金子由佳

統計関連学会連合大会 2018年9月

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On measures of two kinds of symmetry for square contingency tables

Saigusa, Y, Tahata, K, Tomizawa, S

The XXIXth International Biometric Conference 2018年7月

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会議種別：ポスター発表

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分割表解析における対称性の重み付き尺度

三枝祐輔

研究集会「臨床研究・疫学研究の統計学的方法論の発展とその実践」 2018年5月

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順序カテゴリ正方分割表における条件付き対称性の尺度

寺本優太, 三枝祐輔, 富澤貞男

日本統計学会 2018年3月

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会議種別：口頭発表（一般）

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正方分割表における局所対称モデルからの隔たりを測る調和平均型尺度

高見光広, 三枝祐輔, 石井晶, 富澤貞男

日本数学会 2018年3月

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会議種別：口頭発表（一般）

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Generalized mixed model with quasi-linear predictor

三枝祐輔, 小森理, 江口真透

応用統計学会 2021年5月

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準線形予測関数をもつ一般化混合効果モデルについて

三枝祐輔, 小森理, 江口真透

統計関連学会連合大会 2020年9月

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受賞

学生表彰

2017年3月東京理科大学

三枝祐輔

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優秀ポスター発表賞

2014年5月応用統計学会

三枝祐輔

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共同研究・競争的資金等の研究課題

変量効果分布の誤特定に対して頑健な一般化準線形混合効果モデルの開発

研究課題/領域番号：20K19759 2020年4月 - 2023年3月

日本学術振興会科学研究費助成事業若手研究若手研究

三枝祐輔

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担当区分：研究代表者

配分額：1950000円（直接経費：1500000円、間接経費：450000円）

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臨床データ解析における分割表統計解析手法の開発

2018年8月 - 2020年3月

横浜市立大学平成30年度学術的研究推進事業研究奨励プロジェクト「若手支援型」

三枝祐輔

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担当区分：研究代表者資金種別：競争的資金

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重症心疾患患者の全身・嚥下・栄養状態に応じた介入プログラム開発と効果検証

研究課題/領域番号：22H03390 2022年4月 - 2026年3月

日本学術振興会科学研究費助成事業基盤研究(B) 基盤研究(B)

千葉由美, 戸原玄, 野原幹司, 渡邊裕, 三枝祐輔, 内海桃絵, 石上友章, 佐々木康之輔, 吉田俊子, 二藤隆春, 山田律子, 大橋伸英

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配分額：17160000円（直接経費：13200000円、間接経費：3960000円）

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海洋生物多様性ビッグデータ汎用化の基盤技術と海の豊かさを守る応用技術の開発

2021年4月 - 2030年3月

文部科学省海洋資源利用促進技術開発プログラム海洋生物ビッグデータ活用技術高度化

久保田康裕, 山野博哉, 熊谷直喜, 深谷肇一, Garcia Molinos J, 東条斉興, 新垣誠司, 楠本聞太郎, 竹内彰一, 高科直, 小森理, 三枝祐輔

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担当区分：研究分担者

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Learning Health Systemによる慢性腎臓病重症化予防の強化

研究課題/領域番号：19H03870 2019年4月 - 2022年3月

日本学術振興会科学研究費助成事業基盤研究(B) 基盤研究(B)

福間真悟, 山田ゆかり, 後藤励, 田栗正隆, 三枝祐輔, 河本大知, 三角俊裕, 池之上辰義

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担当区分：研究分担者

配分額：17290000円（直接経費：13300000円、間接経費：3990000円）

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アカデミアによる医療情報データベース研究におけるMID-NET利活用に関する研究

2018年8月 - 2022年3月

日本医療研究開発機構医薬品等規制調和・評価研究事業

三角俊裕, 山本紘司, 窪田和巳, 三枝祐輔, 田栗正隆, 飯室聡, 吉村健佑, 花房規男, 桑原政成, 鈴木徳大

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資金種別：競争的資金

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排便時ガスによる大腸癌新規診断法の研究

研究課題/領域番号：18H03550 2018年4月 - 2022年3月

日本学術振興会科学研究費助成事業基盤研究(B) 基盤研究(B)

石部敦士, 渡邉純, 三枝祐輔, 遠藤格, 鈴木紳祐

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配分額：15340000円（直接経費：11800000円、間接経費：3540000円）

本研究は大腸がんの新規診断法として排便ガスの有用性を検討することを目的とする。
大腸がんの診断が排便時のガスで判定できれば、従来の検診よりも、より非侵襲的・簡便に行える可能性がある。
症例集積は大腸がん・大腸ポリープ・健常者、各120例（計360例）を予定している。
排便ガス分析は被験者自宅トイレに排便ガス分析装置を設置し、データを測定している。データの測定はTOTO株式会社へ業務委託を行っている。2018年10月に院内の倫理委員会の承認をえて、2018年12月から症例集積を開始している。
2020年3月31日まで73例（大腸がん 60例（41例増）、大腸ポリープ・健常者 143例（90例増））のデータを集積した。（解析未）

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WHOの自殺予防戦略に基づくがん患者自殺予防プログラムの開発

2018年4月 - 2021年3月

厚生労働省平成30年度厚生労働科学研究費補助金（がん対策推進総合研究事業）

松岡豊, 河西千秋, 内富庸介, 藤森麻衣子, 明智龍男, 一家綱邦, 井上佳祐, 三枝祐輔, 三角俊裕, 島津太一, 野口普子, 川島義高

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担当区分：研究分担者資金種別：競争的資金

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重症患者の全身・摂食嚥下機能に応じたリハビリテーションプログラム開発と効果検証

研究課題/領域番号：17H04458 2017年4月 - 2022年3月

日本学術振興会科学研究費助成事業基盤研究(B) 基盤研究(B)

千葉由美, 戸原玄, 中山渕利, 野原幹司, 渡邊裕, 三枝祐輔, 石上友章, 二藤隆春, 山田律子, 大橋伸英, 市村久美子, 峯岸慎太郎

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担当区分：研究分担者

配分額：16770000円（直接経費：12900000円、間接経費：3870000円）

重症患者（循環器系疾患を有する患者）を対象とした摂食嚥下機能に応じたプログラム作成に際し、調査項目に関する有効な英語論文は昨年の検索分に加え、本年度アップデート分を含めても十分とはいえない状況である。本プロジェクトの研究遂行内容に関する有識者による具体的な話し合いを踏まえ、より質の高い臨床実践プログラム作成に向けて、第一段階のプレ調査（後ろ向き調査）、ならびに調査の不足項目の把握と必要項目の選定を臨床的な視点から行うことが重要であることが確認された。循環器系（外科、内科）の有識者や先進的医療を提供している高度実践者から情報を得ることが必要と考えた。そこで、心臓・肺移植術の提供実績のある米国の急性期病院における胸部外科（心臓・肺）の手術患者を対象とした周手術期管理、摂食嚥下障害に関する実践・医療体制等を視察した。その結果、高度技術を要する手術患者に対しては、全身管理、ならびに肺移植といった誤嚥による移植肺へのダメージに直接影響するリスクを防止するために、患者の全身状態のモニタリングや病院の基準にそった術前、術後の摂食嚥下のリスク評価を行っていた。摂食嚥下のリスク評価や誤嚥予防の具体的内容については、日本でも実施されている一般的な摂食嚥下評価と同様であったが、患者の疾患によって手術後の適応する検査内容は異なっていた。また、手術カンファレンスには、医師や上級看護師であるNP（Nurse Practitioner）をはじめとする多職種が参加し、円滑なチーム医療の体制整備がされていた。これらの知見をもとに、調査項目の精選、ならびに調査準備を進めることが重要と考えた。

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