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Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

As an animal model, we used a 12-week-old Wistar rat cervical spinal cord chronic compression model in which a water-absorbing and swelling material was introduced into the spinal canal. The drug was T817-MA, a neurotrophic factor-like compound. A rotarod was used for rehabilitation. The model was divided into four groups: T817-MA administration and rehabilitation group, T817-MA administration and no rehabilitation group, distilled water administration and rehabilitation group, and distilled water administration and no rehabilitation group. Two types of kinematic analysis were performed: a rotarod walking test and a ladder walking test, and both showed a significant improvement in walking condition in the rehabilitation group treated with T817-MA compared to other groups.

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Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

A comparative study of recovery between the T-817MA-treated group and the non-treated group using a 12-week-old Long-Evans rat frozen coagulation spinal cord injury model showed excellent recovery results in the T-817MA-treated group. Due to the difference in the composition of spinal motor neurons between rats and primates, we started experiments in primates with the aim of early clinical application. A spinal cord half-cut injury model was created in Japanese macaques, and a functional recovery experiment was attempted in the same manner as in rats. It was confirmed that there was a difference in functional recovery between the T-817-administered individuals and the non-administered individuals.

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