Updated on 2025/06/23

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写真a

 
Shingo Kato
 
Organization
Yokohama City University Hospital Department of Clinical Cancer Genomics Associate Professor
Title
Associate Professor
Homepage
http://ycu-hepabiligi.jp/
Profile

横浜市立大学附属病院で、がん遺伝子プロファイリング検査（がんゲノム検査）を担当しています。2023年度より、横浜市立大学附属病院はがんゲノム医療拠点病院に指定されました。

研究では、薬剤代謝及び免疫能が正常な野生型マウスを用いたがん動物モデルを開発し、創薬に挑戦しています。このモデルは、野生型マウスの臓器からオルガノイドを樹立し、in vitroでゲノム編集を行うことでがん化させます。そのがんオルガノイドを簡単かつ大量に同所移植可能な手法を開発し、動物モデルを作成しました。現在、膵癌、胆嚢癌、胆管癌のモデルあります。宿主の抗腫瘍免疫応答を解析できることが利点です。もしご利用になりたい方がいらっしゃいましたら、お気軽にご連絡いただけますと幸いです。

External link

Degree

  • 博士（医学） ( 2012.3   横浜市立大学 )

Research Interests

  • Tumor immunity

  • Genomic Cancer Medicine

  • Cancer animal model

Research Areas

  • Life Science / Tumor diagnostics and therapeutics

  • Life Science / Immunology  / Tumor immunity

Education

  • Yokohama City University   Department of medicine   Postgraduate doctoral course

    2009.4 - 2012.3

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  • Yokohama City University   Graduate School of Medicine

    2000.4 - 2006.3

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Research History

  • Yokohama City University Hospital   Department of Clinical Cancer Genomics   Associate Professor, Department Chair

    2025.4

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  • Yokohama City University Hospital   Department of Clinical Cancer Genomics   Associate Professor

    2024.4 - 2025.3

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  • Yokohama City University Hospital   Department of Clinical Cancer Genomics   Assistant Professor, Deputy Director

    2019.4 - 2024.3

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  • Yokohama City University Hospital   Department of Clinical Cancer Genomics   Assistant professor

    2018.4 - 2019.3

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  • Yokohama City University Hospital   Emergency department   Assistant Professor

    2015.4 - 2018.3

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  • National Cancer Institute / NIH, USA   Vaccine Branch   Visiting Fellow

    2012.6 - 2015.3

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  • Yokohama City University Hospital   Department of Gastroenterology   Resident

    2008.4 - 2012.5

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  • Yokohama City University Hospital   Resident

    2006.4 - 2008.3

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Papers

  • HR eye & MMR eye: one-day assessment of DNA repair-defective tumors eligible for targeted therapy Reviewed

    Shinta Saito, Shingo Kato, Usaki Arai, Atsuki En, Jun Tsunezumi, Taichi Mizushima, Kensuke Tateishi, Noritaka Adachi

    Nature Communications   16 ( 1 )   2025.5

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1038/s41467-025-59462-2

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    Other Link： https://www.nature.com/articles/s41467-025-59462-2

  • Lysosomal processing of sulfatide analogs alters target NKT cell specificity and immune responses in cancer Reviewed

    Kumiko Nishio, Lise Pasquet, Kaddy Camara, Julia DiSapio, Kevin S. Hsu, Shingo Kato, Anja Bloom, Stewart K. Richardson, Joshua A. Welsh, Tianbo Jiang, Jennifer C. Jones, Susanna Cardell, Hiroshi Watarai, Masaki Terabe, Purevdorj B. Olkhanud, Amy R. Howell, Jay A. Berzofsky

    Journal of Clinical Investigation   134 ( 4 )   2024.2

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    Publishing type：Research paper (scientific journal)   Publisher：American Society for Clinical Investigation  

    DOI： 10.1172/jci165281

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  • Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds Reviewed

    Shingo Kato, Kentaro Fushimi, Yuichiro Yabuki, Yoshiaki Maru, Sho Hasegawa, Tetsuya Matsuura, Daisuke Kurotaki, Akihiro Suzuki, Noritoshi Kobayashi, Masato Yoneda, Takuma Higurashi, Makiko Enaka, Tomohiko Tamura, Yoshitaka Hippo, Atsushi Nakajima

    Oncogenesis   10 ( 4 )   2021.4

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    <title>Abstract</title>Genetically engineered mice (GEM) are the gold standard for cancer modeling. However, strict recapitulation of stepwise carcinogenesis from a single tumor-initiating epithelial cell among genetically intact cells in adults is not feasible with the currently available techniques using GEM. In previous studies, we partially overcame this challenge by physically isolating organs from adult animals, followed by genetic engineering in organoids and subcutaneous inoculation in nude mice. Despite the establishment of suitable ex vivo carcinogenesis models for diverse tissues, tumor development remained ectopic and occurred under immunodeficient conditions. Further refinement was, therefore, necessary to establish ideal models. Given the poor prognosis and few models owing to the lack of gall bladder (GB)-specific <italic>Cre</italic> strain, we assumed that the development of authentic models would considerably benefit GB cancer research. Here, we established a novel model using GB organoids with mutant <italic>Kras</italic> and <italic>Trp53</italic> loss generated in vitro by lentiviral <italic>Cre</italic> transduction and CRISPR/Cas9 gene editing, respectively. Organoid-derived subcutaneous tumor fragments were sutured to the outer surface of the GB in syngeneic mice, which developed orthotopic tumors that resembled human GB cancer in histological and transcriptional features. This model revealed the infiltration of similar subsets of immune cells in both subcutaneous and orthotopic tumors, confirming the appropriate immune environment during carcinogenesis. In addition, we accurately validated the in vivo efficacy of gemcitabine, a common therapeutic agent for GB cancer, in large cohorts. Taken together, this model may serve as a promising avatar of patients with GB cancer in drug discovery and precision medicine.

    DOI： 10.1038/s41389-021-00322-1

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    Other Link： http://www.nature.com/articles/s41389-021-00322-1

  • Identification of <scp>TPI1</scp> As a potential therapeutic target in pancreatic cancer with dependency of <scp><i>TP53</i></scp> mutation using multi‐omics analysis

    Tomoaki Toyoda, Nami Miura, Shingo Kato, Takeshi Masuda, Ryuji Ohashi, Akira Matsushita, Fumio Matsuda, Sumio Ohtsuki, Akira Katakura, Kazufumi Honda

    Cancer Science   115 ( 11 )   3622 - 3635   2024.9

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Mutations of KRAS, CDKN2A, TP53, and SMAD4 are the four major driver genes for pancreatic ductal adenocarcinoma (PDAC), of which mutations of KRAS and TP53 are the most frequently recognized. However, molecular‐targeted therapies for mutations of KRAS and TP53 have not yet been developed. To identify novel molecular targets, we newly established organoids with the Kras mutation (Kras<sup>mu</sup>OR) and Trp53 loss of function using Cre transduction and CRISPR/Cas9 (Kras<sup>mu</sup>/p53<sup>mu</sup>OR) from murine epithelia of the pancreatic duct in Kras<sup>LSL‐G12D</sup> mice, and then analyzed the proteomic and metabolomic profiles in both organoids by mass spectrometry. Hyperfunction of the glycolysis pathway was recognized in Kras<sup>mu</sup>/p53<sup>mu</sup>OR compared with Kras<sup>mu</sup>OR. Loss of function of triosephosphate isomerase (TPI1), which is involved in glycolysis, induced a reduction of cell proliferation in human PDAC cell lines with the TP53 mutation, but not in PDAC or in human fibroblasts without TP53 mutation. The TP53 mutation is clinically recognized in 70% of patients with PDAC. In the present study, protein expression of TPI1 and nuclear accumulation of p53 were recognized in the same patients with PDAC. TPI1 is a potential candidate therapeutic target for PDAC with the TP53 mutation.

    DOI： 10.1111/cas.16302

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  • Efficacy and safety of rifaximin in patients with chronic intestinal pseudo-obstruction: a randomized, double-blind, placebo-controlled, phase II-a exploratory trial.

    Hidenori Ohkubo, Takaomi Kessoku, Kosuke Tanaka, Kota Takahashi, Tomohiro Takatsu, Tsutomu Yoshihara, Noboru Misawa, Keiichi Ashikari, Akiko Fuyuki, Shingo Kato, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Toshihiro Misumi, Satoru Shinoda, Vincenzo Stanghellini, Atsushi Nakajima

    Bioscience of microbiota, food and health   43 ( 2 )   135 - 144   2024

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    Language：English   Publishing type：Research paper (scientific journal)  

    Chronic intestinal pseudo-obstruction (CIPO) is a rare intractable disease with limited treatment options. Small intestinal bacterial overgrowth (SIBO) often co-occurs with several diseases, including CIPO. While rifaximin (RFX) is effective in treating SIBO, its efficacy for CIPO remains unclear. Here, we aimed to investigate the efficacy and safety of RFX in adult patients with CIPO. Twelve patients were randomly assigned to receive RFX (400 mg three times daily, n=8) or a placebo (PBO, n=4) for 4 weeks. The global symptom score for abdominal bloating (GSS-bloating) and an original whole gastrointestinal symptoms score (O-WGSS) were collected, and a glucose hydrogen breath test (GHBT) and abdominal computed tomography (CT) were performed. No significant differences were observed in the primary endpoint. GSS-bloating improved by 75% and 25% in the PBO and RFX groups, respectively, and O-WGSS improved by 25% in both groups. No significant differences were observed in secondary and other endpoints, including the SIBO eradication rate in the GHBT and small intestinal volume on CT. In a post hoc analysis of SIBO-positive patients with CIPO (4/4 and 4/8 in the PBO and RFX groups), SIBO was eradicated in 25% and 75% of the patients (PBO and RFX groups, respectively) at the end of treatment, indicating a high eradication rate in the RFX group. Furthermore, the small intestinal gas volume decreased in the RFX group, and no severe adverse events occurred. Although no significant improvements were observed in subjective indicators, RFX may be beneficial in alleviating SIBO and reducing the small intestinal gas volume in SIBO-positive patients with CIPO.

    DOI： 10.12938/bmfh.2023-080

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  • Primary Small Bowel Adenocarcinoma with Metastatic Ovarian Tumor in a Pregnant Woman. International journal

    Yutaro Takahashi, Takayoshi Iijima, Yumi Ishidera, Yuichi Imai, Taichi Mizushima, Daisuke Utsunomiya, Noritoshi Kobayashi, Yasushi Ichikawa, Shingo Kato, Jotaro Harada, Etsuko Miyagi

    Case reports in oncology   17 ( 1 )   882 - 890   2024

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    Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Primary small bowel carcinoma in pregnant women is extremely rare. Small bowel cancer is difficult to diagnose because of its rarity, lack of specific clinical symptoms, and particular anatomical features. We experienced a case of primary small bowel adenocarcinoma with ovarian metastasis during pregnancy. This is the first reported case of a patient with small bowel adenocarcinoma whose pregnancy continued to term and ended in delivery. CASE PRESENTATION: A 32-year-old pregnant woman developed abdominal pain, and imaging examination revealed an ovarian tumor at 29 weeks of gestation. We performed laparotomy and resected the ovarian tumor, which was initially suspected to be primary ovarian cancer. The patient continued the pregnancy to term. A detailed examination of the abdominal cavity during cesarean delivery at 37 weeks revealed that the primary lesion was located in the small bowel. CONCLUSION: It is important to recognize that the small bowel may be the primary site of metastatic ovarian cancer. Detailed and careful examination is necessary to diagnose small bowel cancer during pregnancy.

    DOI： 10.1159/000540524

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  • 肝細胞癌の肝移植後再発に対して,がん遺伝子パネル検査にて有効薬剤の推奨を受けた一例

    室井 健太, 岩城 慶大, 小林 貴, 大谷 知宏, 野上 麻子, 加藤 真吾, 米田 正人, 中島 淳

    日本消化器病学会関東支部例会プログラム・抄録集   377回   36 - 36   2023.12

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    Language：Japanese   Publisher：日本消化器病学会-関東支部  

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  • The Prevalence and Characteristics of Symptomatic Uncomplicated Diverticular Disease Among Asian Patients With Unexplained Abdominal Symptoms

    Tsumugi Jono, Yuki Kasai, Takaomi Kessoku, Tomoki Ogata, Kosuke Tanaka, Tsutomu Yoshihara, Noboru Misawa, Shingo Kato, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Kosuke Seita, Takayuki Kato, Eiji Sakai, Takeo Kurihashi, Machiko Nakatogawa, Shunsuke Oyamada, Seiji Futagami, Kok-Ann Gwee, Atsushi Nakajima

    Journal of Neurogastroenterology and Motility   2023.11

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    Publishing type：Research paper (scientific journal)   Publisher：The Korean Society of Neurogastroenterology and Motility  

    DOI： 10.5056/jnm22162

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  • Intraoperative Integrated Diagnostic System for Malignant Central Nervous System Tumors Reviewed

    Takahiro Hayashi, Kensuke Tateishi, Shinichiro Matsuyama, Hiromichi Iwashita, Yohei Miyake, Akito Oshima, Hirokuni Honma, Jo Sasame, Katsuhiro Takabayashi, Kyoka Sugino, Emi Hirata, Naoko Udaka, Yuko Matsushita, Ikuma Kato, Hiroaki Hayashi, Taishi Nakamura, Naoki Ikegaya, Yutaro Takayama, Masaki Sonoda, Chihiro Oka, Mitsuru Sato, Masataka Isoda, Miyui Kato, Kaho Uchiyama, Tamon Tanaka, Toshiki Muramatsu, Shigeta Miyake, Ryosuke Suzuki, Mutsumi Takadera, Junya Tatezuki, Junichi Ayabe, Jun Suenaga, Shigeo Matsunaga, Kosuke Miyahara, Hiroshi Manaka, Hidetoshi Murata, Takaakira Yokoyama, Yoshihide Tanaka, Takashi Shuto, Koichi Ichimura, Shingo Kato, Shoji Yamanaka, Daniel P. Cahill, Satoshi Fujii, Ganesh M. Shankar, Tetsuya Yamamoto

    Clinical Cancer Research   30 ( 1 )   116 - 126   2023.10

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    Publishing type：Research paper (scientific journal)   Publisher：American Association for Cancer Research (AACR)  

    Abstract

    Purpose:

    The 2021 World Health Organization (WHO) classification of central nervous system (CNS) tumors uses an integrated approach involving histopathology and molecular profiling. Because majority of adult malignant brain tumors are gliomas and primary CNS lymphomas (PCNSL), rapid differentiation of these diseases is required for therapeutic decisions. In addition, diffuse gliomas require molecular information on single-nucleotide variants (SNV), such as IDH1/2. Here, we report an intraoperative integrated diagnostic (i-ID) system to classify CNS malignant tumors, which updates legacy frozen-section (FS) diagnosis through incorporation of a qPCR-based genotyping assay.

    Experimental Design:

    FS evaluation, including GFAP and CD20 rapid IHC, was performed on adult malignant CNS tumors. PCNSL was diagnosed through positive CD20 and negative GFAP immunostaining. For suspected glioma, genotyping for IDH1/2, TERT SNV, and CDKN2A copy-number alteration was routinely performed, whereas H3F3A and BRAF SNV were assessed for selected cases. i-ID was determined on the basis of the 2021 WHO classification and compared with the permanent integrated diagnosis (p-ID) to assess its reliability.

    Results:

    After retrospectively analyzing 153 cases, 101 cases were prospectively examined using the i-ID system. Assessment of IDH1/2, TERT, H3F3AK27M, BRAFV600E, and CDKN2A alterations with i-ID and permanent genomic analysis was concordant in 100%, 100%, 100%, 100%, and 96.4%, respectively. Combination with FS and intraoperative genotyping assay improved diagnostic accuracy in gliomas. Overall, i-ID matched with p-ID in 80/82 (97.6%) patients with glioma and 18/19 (94.7%) with PCNSL.

    Conclusions:

    The i-ID system provides reliable integrated diagnosis of adult malignant CNS tumors.

    DOI： 10.1158/1078-0432.ccr-23-1660

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    Other Link： https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-1660/3383719/ccr-23-1660.pdf

  • Changes in the Number of Gastrointestinal Cancers and Stage at Diagnosis with COVID-19 Pandemic in Japan: A Multicenter Cohort Study. International journal

    Kento Kuzuu, Noboru Misawa, Keiichi Ashikari, Shigeki Tamura, Shingo Kato, Kunihiro Hosono, Masato Yoneda, Takashi Nonaka, Shozo Matsushima, Tatsuji Komatsu, Atsushi Nakajima, Takuma Higurashi

    Cancers   15 ( 17 )   2023.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    This retrospective cohort study compared the number of newly diagnosed patients, stage at diagnosis, and detection process of gastrointestinal cancers based on hospital-based cancer registry data at two tertiary Japanese hospitals. The pre-COVID-19 period was from January 2017 to February 2020, with phase 1 (midst of COVID-19 pandemic) from March to December 2020 and phase 2 (the transition period to the "new normal") from January to December 2021. Each month, the number of patients diagnosed with esophageal, gastric, colorectal, pancreatic, liver, and biliary tract cancers were aggregated, classified by stage and detection process, and compared, including a total of 6453 patients. The number of colorectal Stage 0-II patients decreased significantly in phase 1 and increased in phase 2. The total number of colorectal cancer patients returned to pre-COVID-19 levels (mean monthly patients [SD]: 41.61 [6.81] vs. 36.00 [6.72] vs. 46.00 [11.32]). The number of patients with gastric cancer Stage I significantly decreased in phase 2 following phase 1. The number of gastric cancer patients decreased significantly from pre-COVID-19 levels (30.63 [6.62] vs. 22.40 [5.85] vs. 24.50 [4.15]). During phase 2, the number of patients diagnosed after screening with colorectal cancer increased significantly, whereas that with gastric cancer remained considerably lower. The number of Stage III colorectal and gastric cancer patients increased significantly from the pre-COVID-19 levels. Thus, gastric cancer may not be optimally screened during phases 1 and 2. There was a significant increase in patients with Stage III colorectal and gastric cancers from the pre-COVID-19 period; hence, the stage at diagnosis may have progressed.

    DOI： 10.3390/cancers15174410

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  • AMPAR receptor inhibitors suppress proliferation of human small cell lung cancer cell lines Reviewed

    Nami Masumoto, Shingo Kato, Masahiro Aichi, Sho Hasegawa, Kota Sahara, Kumiko Suyama, Akane Sano, Tomoyuki Miyazaki, Koji Okudela, Takeshi Kaneko, Takuya Takahashi

    Thoracic Cancer   14 ( 29 )   2897 - 2908   2023.8

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Background

    Small cell lung cancer (SCLC) is a neuroendocrine tumor with poor prognosis. Neuroendocrine tumors possess characteristics of both nerve cells and hormone‐secreting cells; therefore, targeting the neuronal properties of these tumors may lead to the development of new therapeutic options. Among the endogenous signaling pathways in the nervous system, targeting the glutamate pathway may be a useful strategy for glioblastoma treatment. Perampanel, an antagonist of the synaptic glutamate α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid receptor (AMPAR), has been reported to be effective in patients with glioblastoma. In this study, we aimed to investigate the antitumor effects of AMPAR antagonists in human SCLC cell lines.

    Methods

    We performed to examine the expression of AMPAR using Western blot and immunohistochemical analysis. The antitumor effects of AMPAR antagonists on human SCLC cell lines were investigated in vitro and in vivo. We also analyzed the signaling pathway of AMPAR antagonists in SCLC cell lines. Statistical analysis was performed by the GraphPad Prism 6 software.

    Results

    We first examined the expression of endogenous AMPAR in six human SCLC cell lines, detecting AMPAR proteins in all of them. Next, we tested the anti−proliferative effect of two AMPAR antagonists, talampanel and cyanquixaline, using SCLC cells in vitro and in vivo. Both AMPAR antagonists inhibited cell proliferation and mitogen‐activated protein kinase (MAPK) phosphorylation in SCLC cells in vitro. Further, we observed reduced proliferation of implanted cell lines in an in vivo setting, assessed by Ki‐67 immunohistochemistry. Additionally, using immunohistochemical analysis we confirmed AMPAR protein expression in human SCLC samples.

    Conclusion

    AMPAR may be a potential therapeutic target for SCLC.

    DOI： 10.1111/1759-7714.15075

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  • Natural History of Chronic Intestinal Pseudo-obstruction and Need for Palliative Care. International journal

    Kosuke Tanaka, Hidenori Ohkubo, Atsushi Yamamoto, Kota Takahashi, Yuki Kasai, Anna Ozaki, Michihiro Iwaki, Takashi Kobayashi, Tsutomu Yoshihara, Noboru Misawa, Akiko Fuyuki, Shingo Kato, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Takeo Kurihashi, Masataka Taguri, Atsushi Nakajima, Kok-Ann Gwee, Takaomi Kessoku

    Journal of neurogastroenterology and motility   29 ( 3 )   378 - 387   2023.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND/AIMS: Natural history of chronic intestinal pseudo-obstruction (CIPO), a rare disease characterized by episodes of non-mechanical obstruction, is unclear in adults. This study evaluates the clinical course of CIPO and palliative care needs of patients. METHODS: From October 2010 to September 2021, 74 patients who underwent cine MRI and had a definitive diagnosis of CIPO were prospectively included. We investigated disease etiology and outcomes, age at onset, nutritional status at consultation (body mass index and serum albumin), hydrogen breath test results, and total parenteral nutrition (TPN) during the disease course. RESULTS: Forty-seven patients (64%) were women, with a mean age of 44 years at onset and 49 years at diagnosis. Primary CIPO was observed in 48 patients (65%). Secondary CIPO was observed in 26 cases (35%), of whom 18 (69%) had scleroderma. The mean body mass index, serum albumin level, and hydrogen breath test positivity rate were 17 kg/m2, 3.8 mg/dL, and 60%, respectively. TPN and invasive decompression therapy were required by 23 (31%) and 18 (24%) patients, respectively. Intestinal sterilization was performed in 51 (69%) patients and was effective in 33 (65%); of these, 28 (85%) were taking metronidazole. Seven (9%) patients used opioids. There were 9 deaths (12%), including 5 (56%) from infection and 2 (22%) from suicide. Of the deaths, 6 (67%) and 4 (44%) underwent TPN management and decompression therapy, respectively. Fifty-one patients (69%) wanted palliative care. CONCLUSION: CIPO is a rare, severe, and under-recognized disease. Standardization of treatment strategies, including palliative care and psychiatric interventions, is desired.

    DOI： 10.5056/jnm22152

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  • Low skeletal muscle mass predicts poor prognosis for patients with stage III cervical cancer on concurrent chemoradiotherapy

    Masahiro Aichi, Sho Hasegawa, Yusuke Kurita, Satoru Shinoda, Shingo Kato, Taichi Mizushima, Naho Ruiz Yokota, Etsuko Miyagi

    Nutrition   109   111966 - 111966   2023.5

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.nut.2022.111966

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  • Clinical utility of Todai OncoPanel in the setting of approved comprehensive cancer genomic profiling tests in Japan

    Hidenori Kage, Aya Shinozaki‐Ushiku, Kazunaga Ishigaki, Yusuke Sato, Masahiko Tanabe, Shota Tanaka, Michihiro Tanikawa, Kousuke Watanabe, Shingo Kato, Kiwamu Akagi, Keita Uchino, Kinuko Mitani, Shunji Takahashi, Yuji Miura, Sadakatsu Ikeda, Yasushi Kojima, Kiyotaka Watanabe, Hitoshi Mochizuki, Hironori Yamaguchi, Yoshimasa Kawazoe, Kosuke Kashiwabara, Shinji Kohsaka, Kenji Tatsuno, Tetsuo Ushiku, Kazuhiko Ohe, Yutaka Yatomi, Yasuyuki Seto, Hiroyuki Aburatani, Hiroyuki Mano, Kiyoshi Miyagawa, Katsutoshi Oda

    Cancer Science   2023.1

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/cas.15717

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.15717

  • EUS-BDの早期偶発症に関する因子

    佐藤 高光, 細野 邦広, 長谷川 翔, 栗田 裕介, 八木 伸, 鈴木 洸, 加藤 真吾, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   64 ( Suppl.2 )   2118 - 2118   2022.10

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    Language：Japanese   Publisher：(一社)日本消化器内視鏡学会  

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  • Franseen Needles May Be Promising for Improving the Sampling Adequacy of EUS-FNA for Subepithelial Lesions. International journal

    Noriki Kasuga, Yusuke Kurita, Emiko Tanida, Shin Yagi, Ko Suzuki, Sho Hasegawa, Takamitsu Sato, Kunihiro Hosono, Shingo Kato, Yusuke Sekino, Noritoshi Kobayashi, Itaru Endo, Kensuke Kubota, Atsushi Nakajima

    Diagnostics (Basel, Switzerland)   12 ( 7 )   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is useful in diagnosing subepithelial lesions (SELs), and adequate tissue sampling is necessary to differentiate between benign and malignant diseases to determine therapeutic strategies. This study aimed to evaluate sampling adequacy and diagnostic performance of EUS-FNA for SELs with Franseen needles. This retrospective study enrolled 130 patients who underwent EUS-FNA with a 22-gauge needle for SELs from January 2010 to March 2021. We compared sampling adequacy and predictive factors influencing the sampling adequacy of EUS-FNA for SELs between Franseen and conventional needles. The sampling adequacy rates were 95.0% (38/40) with Franseen needles and 76.7% (69/90) with conventional needles (p = 0.011). The mean number of punctures with Franseen needles (2.80) was significantly less than that with conventional needles (3.42) (p &lt; 0.001). In the multivariate analysis, the use of Franseen needles (p = 0.029; odds ratio [OR], 5.37; 95% confidence interval [CI], 1.18-23.36) was an independent factor influencing the sampling adequacy. Compared to conventional needles, the Franseen needle could play a vital role in accurately diagnosing SELs by yielding better sampling adequacy and reducing the number of passes.

    DOI： 10.3390/diagnostics12071667

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  • Association of Serum and Fecal Bile Acid Patterns With Liver Fibrosis in Biopsy-Proven Nonalcoholic Fatty Liver Disease: An Observational Study. International journal

    Yuki Kasai, Takaomi Kessoku, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Takashi Kobayashi, Michihiro Iwaki, Anna Ozaki, Asako Nogami, Yasushi Honda, Yuji Ogawa, Shingo Kato, Kento Imajo, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Haruki Usuda, Koichiro Wada, Miwa Kawanaka, Takumi Kawaguchi, Takuji Torimura, Masayoshi Kage, Hideyuki Hyogo, Hirokazu Takahashi, Yuichiro Eguchi, Shinichi Aishima, Noritoshi Kobayashi, Yoshio Sumida, Akira Honda, Shunsuke Oyamada, Satoru Shinoda, Satoru Saito, Atsushi Nakajima

    Clinical and translational gastroenterology   13 ( 7 )   e00503   2022.7

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    INTRODUCTION: No reports on both blood and fecal bile acids (BAs) in patients with nonalcoholic fatty liver disease (NAFLD) exist. We simultaneously assessed the serum and fecal BA patterns in healthy participants and those with NAFLD. METHODS: We collected stool samples from 287 participants from 5 hospitals in Japan (healthy control [HC]: n = 88; mild fibrosis: n = 104; and advanced fibrosis group: n = 95). Blood samples were collected and analyzed for serum BAs and 7α-hydroxy-4-cholesten-3-one (C4)-a surrogate marker for BA synthesis ability-from 141 patients. Concentrations of BAs, including cholic acid (CA), deoxycholic acid (DCA), chenodeoxycholic acid, ursodeoxycholic acid, and lithocholic acid (LCA), were measured using liquid chromatography-mass spectrometry. RESULTS: The total fecal BA concentration was significantly higher in the NAFLD group with worsening of fibrosis than in the HC group. Most of the fecal BAs were secondary and unconjugated. In the fecal BA fraction, CA, DCA, chenodeoxycholic acid, ursodeoxycholic acid, and LCA were significantly higher in the NAFLD than in the HC group. The total serum BA concentration was higher in the NAFLD group with worsening of fibrosis than in the HC group. In the serum BA fraction, CA, LCA, and C4 concentrations were significantly higher in the NAFLD than in the HC group. DISCUSSION: Fecal and serum BA and C4 concentrations were high in patients with NAFLD with worsening of fibrosis, suggesting involvement of abnormal BA metabolism in NAFLD with fibrosis progression. Abnormalities in BA metabolism may be a therapeutic target in NAFLD with fibrosis.

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  • Effectiveness and Prognostic Factors of Everolimus in Patients with Pancreatic Neuroendocrine Neoplasms.

    Yusuke Kurita, Noritoshi Kobayashi, Kazuo Hara, Nobumasa Mizuno, Takamichi Kuwahara, Nozomi Okuno, Shin Haba, Motohiko Tokuhisa, Sho Hasegawa, Takamitsu Sato, Kunihiro Hosono, Shingo Kato, Takaomi Kessoku, Itaru Endo, Yasuhiro Shimizu, Kensuke Kubota, Atsushi Nakajima, Yasushi Ichikawa, Yasumasa Niwa

    Internal medicine (Tokyo, Japan)   2022.6

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    Objective The effectiveness of everolimus for the management of pancreatic neuroendocrine neoplasms (PNENs), including the G3/NEC types, remains unclear. We therefore investigated the effectiveness of the drug for the management of PNENs. Methods We analyzed the progression-free survival (PFS) and overall survival (OS) associated with everolimus and factors influencing the PFS and OS. Results One hundred patients were evaluated. The PFS associated with the G1/G2 types tended to be significantly longer than that associated with the G3/NEC types (hazard ratio [HR], 0.45; p =0.005). A multivariate analysis showed that the significant factors influencing the PFS were age (<65 years old; HR, 0.44; p =0.002), grade (G1/G2; HR, 0.42; p =0.006), everolimus treatment line (≤2nd; HR, 0.55; p =0.031), and presence of treatment with metformin (yes; HR, 0.29; p =0.044). The median OS was 63.8 months. In the multivariate analysis, the significant factors influencing the OS were grade (G1/G2; HR, 0.21; p <0.001), volume of liver metastasis (≤25%; HR, 0.27; p <0.001), everolimus treatment line (≤2nd; HR, 0.27; p <0.001), and presence of primary tumor resection (yes; HR, 0.33; p =0.005). Conclusions The effectiveness of everolimus in the management of G3/NEC types and prognoses tended to be poorer than those associated with the G1/G2 types. Everolimus combined with metformin and early-line treatment with everolimus may be effective for managing advanced PNENs.

    DOI： 10.2169/internalmedicine.9416-22

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  • 悪性肝門部狭窄に対するステント予定交換により安定した治療を目指す

    佐藤 高光, 細野 邦広, 窪田 賢輔, 長谷川 翔, 栗田 裕介, 八木 伸, 鈴木 洸, 加藤 真吾, 佐藤 元一, 中島 淳

    Gastroenterological Endoscopy   64 ( Suppl.1 )   770 - 770   2022.4

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  • Learning Curve of Endoscopic Retrograde Cholangiopancreatography Using Single-Balloon Enteroscopy. International journal

    Kunihiro Hosono, Takamitsu Sato, Sho Hasegawa, Yusuke Kurita, Shin Yagi, Akito Iwasaki, Yuji Fujita, Yusuke Sekino, Emiko Tanida, Takaomi Kessoku, Shingo Kato, Takuma Higurashi, Masato Yoneda, Kensuke Kubota, Atsushi Nakajima

    Digestive diseases and sciences   67 ( 7 )   2882 - 2890   2022.1

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    BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) in patients with surgically altered anatomy is technically difficult. Extensive training is required to develop the ability to perform this procedure. AIMS: To investigate the learning curve of single-balloon-assisted enteroscopy ERCP (SBE-ERCP). METHODS: We conducted a retrospective, observational case series at a single center. We evaluated the SBE-ERCP procedures between April 2011 and February 2021. The main outcomes were the rate of reaching the target site and the success rate of the entire procedure. These parameters were additionally expressed as a learning curve. RESULTS: A total of 687 SBE-ERCP procedures were analyzed. The learning curve was analyzed in blocks of 10 cases. In this study, seven endoscopists, experts in conventional ERCP, were included. The overall SBE-ERCP procedural success rate was 92.2% (634/687 cases). Combining all data from individual endoscopists' evaluation periods, the insertion and success rates of the SBE-ERCP procedures gradually increased with increased experience performing SBE-ERCP. The insertion success rates for the number of SBE-ERCP cases (< 20, 21-30, > 30) were 82.9%, 92.9%, and 94.3%, respectively; the procedure success rates were 74.3%, 81.4%, and 92.9%, respectively. The endoscopists who had performed > 30 SBE-ERCP cases had a success rate of ≥ 90%. CONCLUSIONS: Our results suggest that performing > 30 cases is one of the targets for conventional ERCP experts to become competent in performing SBE-ERCP in patients with a surgically altered anatomy.

    DOI： 10.1007/s10620-021-07342-2

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  • Risk of cardiovascular disease in patients with fatty liver disease as defined from the metabolic dysfunction associated fatty liver disease or nonalcoholic fatty liver disease point of view: a retrospective nationwide claims database study in Japan.

    Masato Yoneda, Takuma Yamamoto, Yasushi Honda, Kento Imajo, Yuji Ogawa, Takaomi Kessoku, Takashi Kobayashi, Asako Nogami, Takuma Higurashi, Shingo Kato, Kunihiro Hosono, Satoru Saito, Atsushi Nakajima

    Journal of gastroenterology   56 ( 11 )   1022 - 1032   2021.11

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    BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction associated fatty liver disease (MAFLD) have important associations with cardiovascular disease (CVD). The main objective of this study was to compare the frequency of incidence rate of CVD in the NAFLD or MAFLD patients utilizing a large claims database. METHODS: Using the JMDC database from April 2013 to March 2019, we retrospectively analyzed data for 1,542,688 and 2,452,949 people to estimate the relationship between CVD and NAFLD, MAFLD, respectively. RESULTS: The incidence rates of CVD were 0.97 (95% CI 0.94-1.01) and 2.82 (95% CI 2.64-3.01) per 1000 person-years in the non-NAFLD and NAFLD groups, respectively, and 1.01 (95% CI 0.98-1.03) and 2.69 (95% CI 2.55-2.83) per 1000 person-years in the non-MAFLD and MAFLD groups, respectively. The overall prevalence of hypertriglyceridemia and diabetes mellitus (DM) was 13.1, and 4.2%, respectively, in the non-NAFLD group and 63.6, and 20.2%, respectively, in the NAFLD group. The overall prevalenceof hypertriglyceridemia and DM was 13.6 and 4.3%, respectively, in the non-MAFLD group and 64.1, and 20.6%, respectively, in the MAFLD group. HRs for CVD increased with hypertriglyceridemia and DM. CONCLUSIONS: Results indicated that incident rate of CVD increased with NAFLD/MAFLD; the complication rate of DM and hypertriglyceridemia among NAFLD/MAFLD patients is high and may affect the development of CVD.

    DOI： 10.1007/s00535-021-01828-6

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  • 肝移植後胆管狭窄の現状と治療についての検討

    鈴木 洸, 栗田 裕介, 長谷川 翔, 佐藤 高光, 加藤 真吾, 細野 邦広, 窪田 賢輔, 中島 淳

    日本消化器病学会雑誌   118 ( 臨増大会 )   A782 - A782   2021.10

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  • 胆管空腸吻合術後の肝内結石症に対する完全切石Strategy

    佐藤 高光, 細野 邦広, 長谷川 翔, 栗田 裕介, 八木 伸, 加藤 真吾, 窪田 賢輔, 中島 淳

    Gastroenterological Endoscopy   63 ( Suppl.2 )   2078 - 2078   2021.10

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  • Gastrointestinal Cancer Stage at Diagnosis Before and During the COVID-19 Pandemic in Japan

    Kento Kuzuu, Noboru Misawa, Keiichi Ashikari, Takaomi Kessoku, Shingo Kato, Kunihiro Hosono, Masato Yoneda, Takashi Nonaka, Shozo Matsushima, Tatsuji Komatsu, Atsushi Nakajima, Takuma Higurashi

    JAMA Network Open   4 ( 9 )   e2126334 - e2126334   2021.9

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    DOI： 10.1001/jamanetworkopen.2021.26334

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  • Evaluation of a combination protocol of CT-first triage and active telemedicine methods by a selected team tackling COVID-19: An experimental research study

    Shigeta Miyake, Takuma Higurashi, Hideaki Kato, Yutaro Yamaoka, Takaomi Kessoku, Shingo Kato, Fumihiro Ogawa, Yasufumi Oi, Atsushi Nakajima, Tetsuya Yamamoto, Ichiro Takeuchi, Akihide Ryo, Shin Maeda

    Journal of Infection and Public Health   14 ( 9 )   1212 - 1217   2021.9

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    DOI： 10.1016/j.jiph.2021.08.016

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  • 膵癌治療(ステント) 膵管空腸吻合術後狭窄に対する内視鏡治療の長期成績

    佐藤 高光, 細野 邦広, 長谷川 翔, 栗田 裕介, 八木 伸, 加藤 真吾, 窪田 賢輔, 中島 淳

    膵臓   36 ( 3 )   A295 - A295   2021.8

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  • ロング型シングルバルーンを基盤とした胆管空腸吻合術後の内視鏡Management

    佐藤 高光, 細野 邦広, 窪田 賢輔, 長谷川 翔, 栗田 裕介, 八木 伸, 加藤 真吾, 中島 淳

    胆道   35 ( 3 )   466 - 466   2021.8

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  • The Role of Leaky Gut in Nonalcoholic Fatty Liver Disease: A Novel Therapeutic Target

    Takaomi Kessoku, Takashi Kobayashi, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Michihiro Iwaki, Anna Ozaki, Yuki Kasai, Asako Nogami, Yasushi Honda, Yuji Ogawa, Shingo Kato, Kento Imajo, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Haruki Usuda, Koichiro Wada, Satoru Saito, Atsushi Nakajima

    International Journal of Molecular Sciences   22 ( 15 )   8161 - 8161   2021.7

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    The liver directly accepts blood from the gut and is, therefore, exposed to intestinal bacteria. Recent studies have demonstrated a relationship between gut bacteria and nonalcoholic fatty liver disease (NAFLD). Approximately 10–20% of NAFLD patients develop nonalcoholic steatohepatitis (NASH), and endotoxins produced by Gram-negative bacilli may be involved in NAFLD pathogenesis. NAFLD hyperendotoxicemia has intestinal and hepatic factors. The intestinal factors include impaired intestinal barrier function (leaky gut syndrome) and dysbiosis due to increased abundance of ethanol-producing bacteria, which can change endogenous alcohol concentrations. The hepatic factors include hyperleptinemia, which is associated with an excessive response to endotoxins, leading to intrahepatic inflammation and fibrosis. Clinically, the relationship between gut bacteria and NAFLD has been targeted in some randomized controlled trials of probiotics and other agents, but the results have been inconsistent. A recent randomized, placebo-controlled study explored the utility of lubiprostone, a treatment for constipation, in restoring intestinal barrier function and improving the outcomes of NAFLD patients, marking a new phase in the development of novel therapies targeting the intestinal barrier. This review summarizes recent data from studies in animal models and randomized clinical trials on the role of the gut–liver axis in NAFLD pathogenesis and progression.

    DOI： 10.3390/ijms22158161

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  • 高齢者消化器がん化学療法〜高齢者のがん治療を安全・効果的に遂行するための取り組み 切除不能進行膵癌において、サルコペニアの有無はFOLFILINOX導入の判断指標になりえる

    鈴木 洸, 栗田 裕介, 長谷川 翔, 佐藤 高光, 加藤 真吾, 細野 邦広, 小林 規俊, 窪田 賢輔, 中島 淳

    日本高齢消化器病学会誌   24 ( 1 )   119 - 119   2021.7

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  • IgG4‐related sclerosing cholangitis may be a risk factor for cancer

    Yusuke Kurita, Yuji Fujita, Yusuke Sekino, Seitaro Watanabe, Akito Iwasaki, Koichi Kagawa, Emiko Tanida, Shin Yagi, Sho Hasegawa, Takamitsu Sato, Kunihiro Hosono, Shingo Kato, Noritoshi Kobayashi, Yasushi Ichikawa, Itaru Endo, Atsushi Nakajima, Kensuke Kubota

    Journal of Hepato-Biliary-Pancreatic Sciences   28 ( 6 )   524 - 532   2021.6

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    DOI： 10.1002/jhbp.957

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  • Recent Advances in Implantation-Based Genetic Modeling of Biliary Carcinogenesis in Mice

    Masashi Izumiya, Shingo Kato, Yoshitaka Hippo

    Cancers   13 ( 10 )   2292 - 2292   2021.5

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    Epithelial cells in the biliary system can develop refractory types of cancers, which are often associated with inflammation caused by viruses, parasites, stones, and chemicals. Genomic studies have revealed recurrent genetic changes and deregulated signaling pathways in biliary tract cancer (BTC). The causal roles have been at least partly clarified using various genetically engineered mice. Technical advances in Cre-LoxP technology, together with hydrodynamic tail injection, CRISPR/Cas9 technology, in vivo electroporation, and organoid culture have enabled more precise modeling of BTC. Organoid-based genetic modeling, combined with implantation in mice, has recently drawn attention as a means to accelerate the development of BTC models. Although each model may not perfectly mimic the disease, they can complement one another, or two different approaches can be integrated to establish a novel model. In addition, a comparison of the outcomes among these models with the same genotype provides mechanistic insights into the interplay between genetic alterations and the microenvironment in the pathogenesis of BTCs. Here, we review the current status of genetic models of BTCs in mice to provide information that facilitates the wise selection of models and to inform the future development of ideal disease models.

    DOI： 10.3390/cancers13102292

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  • EUS-BD関連偶発症の包括的検討 より安全な手技を目指して

    佐藤 高光, 細野 邦広, 八木 伸, 栗田 裕介, 長谷川 翔, 加藤 真吾, 窪田 賢輔, 中島 淳

    Gastroenterological Endoscopy   63 ( Suppl.1 )   931 - 931   2021.4

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  • 術後再建腸管に合併した胆管結石に対する包括的治療戦略

    長谷川 翔, 細野 邦広, 中島 淳, 八木 伸, 栗田 裕介, 佐藤 高光, 加藤 真吾, 窪田 賢輔

    日本消化器病学会雑誌   118 ( 臨増総会 )   A326 - A326   2021.3

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  • Severe acute respiratory syndrome coronavirus 2 prevalence in saliva and gastric and intestinal fluid in patients undergoing gastrointestinal endoscopy in coronavirus disease 2019 endemic areas: Prospective cross-sectional study in Japan. International journal

    Shigeta Miyake, Keiichi Ashikari, Shingo Kato, Tomohiro Takatsu, Hirofumi Kuwashima, Hiroaki Kaneko, Koki Nagai, Ikue Watari, Takamitsu Sato, Yutaro Yamaoka, Tetsuya Yamamoto, Akihide Ryo, Shin Maeda, Atsushi Nakajima, Takuma Higurashi

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   34 ( 1 )   96 - 104   2021.2

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    OBJECTIVES: Gastrointestinal endoscopy (GIE) is useful for the early detection and treatment of many diseases; however, GIE is considered a high-risk procedure in the coronavirus disease 2019 (COVID-19) pandemic era. This study aimed to explore the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity in saliva and gastrointestinal fluids to which endoscopy medical staff are exposed. METHODS: The study was a single-center cross-sectional study. From June 1 to July 31, 2020, all patients who underwent GIE at Yokohama City University Hospital were registered. All patients provided 3 mL of saliva. For upper GIE, 10 mL of gastric fluid was collected through the endoscope. For lower GIE, 10 mL of intestinal fluid was collected through the endoscope. The primary outcome was the positive rate of SARS-CoV-2 in saliva and gastrointestinal fluids. We also analyzed serum-specific antibodies for SARS-CoV-2 and patients' background information. RESULTS: A total of 783 samples (560 upper GIE and 223 lower GIE samples) were analyzed. Polymerase chain reaction (PCR) on saliva samples did not show any positive results in either upper or lower GIE samples. However, 2.0% (16/783) of gastrointestinal fluid samples tested positive for SARS-CoV-2. No significant differences in age, sex, purpose of endoscopy, medication, or rate of antibody test positivity were found between PCR positive and PCR negative cases. CONCLUSIONS: Asymptomatic patients, even those with no detectable virus in their saliva, had SARS-CoV-2 in their gastrointestinal tract. Endoscopy medical staff should be aware of infection when performing procedures. The study was registered as UMIN000040587.

    DOI： 10.1111/den.13945

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  • Endotoxins and Non-Alcoholic Fatty Liver Disease. International journal

    Takaomi Kessoku, Takashi Kobayashi, Kento Imajo, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Yuki Kasai, Anna Ozaki, Michihiro Iwaki, Asako Nogami, Yasushi Honda, Yuji Ogawa, Shingo Kato, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Takayuki Okamoto, Haruki Usuda, Koichiro Wada, Noritoshi Kobayashi, Satoru Saito, Atsushi Nakajima

    Frontiers in endocrinology   12   770986 - 770986   2021

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    Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. It occurs with a prevalence of up to 25%, of which 10-20% cases progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. The histopathology of NASH is characterized by neutrophilic infiltration, and endotoxins from gram-negative rods have been postulated as a contributing factor. Elevations in endotoxin levels in the blood can be classified as intestinal and hepatic factors. In recent years, leaky gut syndrome, which is characterized by impaired intestinal barrier function, has become a significant issue. A leaky gut may prompt intestinal bacteria dysbiosis and increase the amount of endotoxin that enters the liver from the portal vein. These contribute to persistent chronic inflammation and progressive liver damage. In addition, hepatic factors suggest that liver damage can be induced by low-dose endotoxins, which does not occur in healthy individuals. In particular, increased expression of CD14, an endotoxin co-receptor in the liver, may result in leptin-induced endotoxin hyper-responsiveness in obese individuals. Thus, elevated blood endotoxin levels contribute to the progression of NASH. The current therapeutic targets for NASH treat steatosis and liver inflammation and fibrosis. While many clinical trials are underway, no studies have been performed on therapeutic agents that target the intestinal barrier. Recently, a randomized placebo-controlled trial examined the role of the intestinal barrier in patients with NAFLD. To our knowledge, this study was the first of its kind and study suggested that the intestinal barrier may be a novel target in the future treatment of NAFLD.

    DOI： 10.3389/fendo.2021.770986

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  • Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial

    Takaomi Kessoku, Kento Imajo, Takashi Kobayashi, Anna Ozaki, Michihiro Iwaki, Yasushi Honda, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Shingo Kato, Takuma Higurashi, Masato Yoneda, Hiroyuki Kirikoshi, Kazumi Kubota, Masataka Taguri, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Noritoshi Kobayashi, Satoru Saito, Atsushi Nakajima

    The Lancet Gastroenterology & Hepatology   5 ( 11 )   996 - 1007   2020.11

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    DOI： 10.1016/s2468-1253(20)30216-8

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  • EFFICACY AND SAFETY OF LUBIPROSTONE TREATMENT FOR NON-ALCOHOLIC FATTY LIVER DISEASE WITH ADVANCED FIBROSIS: A POST-HOC ANALYSIS OF THE LUBIPRONE RANDOMIZED TRIAL.

    Takaomi Kessoku, Takashi Kobayashi, Yuki Kasai, Anna Ozaki, Michihiro Iwaki, Yasushi Honda, Yuji Ogawa, Kento Imajo, Shingo Kato, Takuma Higurashi, Masato Yoneda, Kazumi Kubota, Masataka Taguri, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Satoru Saito, Atsushi Nakajima

    HEPATOLOGY   72   1017 - 1017   2020.11

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  • 術前放射線化学療法中の膵癌に対する内視鏡的胆道ドレナージの治療成績

    長谷川 翔, 栗田 裕介, 佐藤 高光, 細野 邦広, 加藤 真吾, 遠藤 格, 窪田 賢輔, 中島 淳

    Gastroenterological Endoscopy   62 ( Suppl.2 )   2165 - 2165   2020.10

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  • The placement of multiple plastic stents still has important roles in candidates for chemotherapy for unresectable perihilar cholangiocarcinoma

    Akito Iwasaki, Kensuke Kubota, Yusuke Kurita, Sho Hasegawa, Yuji Fujita, Koji Kagawa, Shingo Kato, Yusuke Sekino, Kunihiro Hosono, Atsushi Nakajima

    Journal of Hepato-Biliary-Pancreatic Sciences   27 ( 10 )   700 - 711   2020.10

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    DOI： 10.1002/jhbp.804

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  • EUS-BDの手技完遂における環境とは

    佐藤 高光, 栗田 裕介, 長谷川 翔, 加藤 真吾, 細野 邦広, 窪田 賢輔, 中島 淳

    Gastroenterological Endoscopy   62 ( Suppl.2 )   2168 - 2168   2020.10

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  • The protective effect of Bifidobacterium bifidum G9-1 against mucus degradation by Akkermansia muciniphila following small intestine injury caused by a proton pump inhibitor and aspirin. Reviewed International journal

    Tsutomu Yoshihara, Yosuke Oikawa, Takayuki Kato, Takaomi Kessoku, Takashi Kobayashi, Shingo Kato, Noboru Misawa, Keiichi Ashikari, Akiko Fuyuki, Hidenori Ohkubo, Takuma Higurashi, Yoko Tateishi, Yoshiki Tanaka, Shunji Nakajima, Hiroshi Ohno, Koichiro Wada, Atsushi Nakajima

    Gut microbes   11 ( 5 )   1385 - 1404   2020.9

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    BACKGROUND: Proton pump inhibitors (PPIs) can alleviate upper gastrointestinal injury but paradoxically exacerbate aspirin (ASA)-induced small intestine injury. In this study, our goal was to simulate this exacerbation by developing an appropriate animal model, which may help in establishing treatments. Methods: Male mice were fed a 60% fructose diet for 9 weeks, then administered 200 mg/kg ASA 3 h before sacrifice. The PPI omeprazole was administered intraperitoneally once daily for 9 weeks. Bifidobacterium bifidum G9-1 was administered orally for the last week. In addition, Akkermansia muciniphila was administered orally for 9 weeks instead of omeprazole. Results: ASA-induced small-intestine injury was observed in high-fructose fed mice. Omeprazole exacerbated ASA-induced intestinal damage, significantly decreased Bifidobacteria levels, and significantly increased A. muciniphila counts in the jejunum. The direct administration of A. muciniphila caused thinning of the jejunum mucus layer, which was also observed in mice that received ASA and omeprazole. On the other hand, the administration of Bifidobacterium bifidum G9-1 inhibited A. muciniphila growth and reduced thinning of the mucus layer. The number of goblet cells in the jejunum was reduced by the administration of ASA and omeprazole, while Bifidobacterium bifidum G9-1 prevented the reduction. Conclusions: These results suggest that omeprazole-induced gut dysbiosis promotes Akkermansia growth and inhibits Bifidobacterium growth, leading to a thinning of the mucus layer through a reduction in goblet cells in the small intestine. Probiotics are, therefore, a promising approach for the treatment of small intestine injury.

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  • 難渋する胆道ドレナージの工夫 悪性肝門部胆管狭窄に対するEBDとEUS-HGSによるHybrid drainageの工夫

    佐藤 高光, 細野 邦広, 窪田 賢輔, 栗田 裕介, 長谷川 翔, 加藤 真吾, 中島 淳

    胆道   34 ( 3 )   431 - 431   2020.8

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  • Use of Biomarkers and Imaging for Early Detection of Pancreatic Cancer. Reviewed International journal

    Shingo Kato, Kazufumi Honda

    Cancers   12 ( 7 )   1965 - 1965   2020.7

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    Pancreatic cancer remains one of the deadliest cancers worldwide, and it is typically diagnosed late, with a poor prognosis. Early detection is the most important underlying factor for improving the prognosis of pancreatic cancer patients. One of the most effective strategies for detecting cancers at an early stage is screening of the general population. However, because of the low incidence of pancreatic cancer in the general population, the stratification of subjects who need to undergo further examinations by invasive and expensive modalities is important. Therefore, minimally invasive modalities involving biomarkers and imaging techniques that would facilitate the early detection of pancreatic cancer are highly needed. Multiple types of new blood biomarkers have recently been developed, including unique post-translational modifications of circulating proteins, circulating exosomes, microRNAs, and circulating tumor DNA. We previously reported that circulating apolipoprotein A2 undergoes unique processing in the bloodstream of patients with pancreatic cancer and its precancerous lesions. Additionally, we recently demonstrated a new method for measuring pancreatic proton density in the fat fraction using a fat-water magnetic resonance imaging technique that reflects pancreatic steatosis. In this review, we describe recent developments in potential biomarkers and imaging modalities for the early detection and risk stratification of pancreatic cancer, and we discuss current strategies for implementing screening programs for pancreatic cancer.

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  • The influence of HLA-B51 on clinical manifestations among Japanese patients with Behçet’s disease: A nationwide survey

    Yuki Mizuki, Nobuyuki Horita, Yukihiro Horie, Masaki Takeuchi, Takehito Ishido, Ryuta Mizuki, Tatsukata Kawagoe, Etsuko Shibuya, Kentaro Yuda, Mizuho Ishido, Kaoru Minegishi, Ryusuke Yoshimi, Yohei Kirino, Shingo Kato, Jun Arimoto, Takeshi Fukumoto, Michiko Kurosawa, Nobuyoshi Kitaichi, Mitsuhiro Takeno, Takeshi Kaneko, Nobuhisa Mizuki

    Modern Rheumatology   30 ( 4 )   708 - 714   2020.7

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    DOI： 10.1080/14397595.2019.1649103

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  • Organoid-based ex vivo reconstitution of Kras-driven pancreatic ductal carcinogenesis

    Tetsuya Matsuura, Yoshiaki Maru, Masashi Izumiya, Daisuke Hoshi, Shingo Kato, Masako Ochiai, Mika Hori, Shogo Yamamoto, Kenji Tatsuno, Toshio Imai, Hiroyuki Aburatani, Atsushi Nakajima, Yoshitaka Hippo

    Carcinogenesis   41 ( 4 )   490 - 501   2020.6

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    The organoid culture technique has been recently applied to modeling carcinogenesis in several organs. To further explore its potential and gain novel insights into tumorigenesis, we here investigated whether pancreatic ductal adenocarcinoma (PDA) could be generated as subcutaneous tumors in immunocompromised nude mice, by genetic engineering of normal organoids. As expected, acute induction of KrasG12Din vitro occasionally led to development of tiny nodules compatible with early lesions known as pancreatic intraepithelial neoplasia (PanIN). KrasG12D-expressing cells were enriched after inoculation in the subcutis, yet proved rather declined during culture, suggesting that its advantage might depend on surrounding environments. Depletion of growth factors or concurrent Trp53 deletion resulted in its robust enrichment, invariably leading to development of PanIN or large high-grade adenocarcinoma, respectively, consistent with in vivo mouse studies for the same genotype. Progression from PanIN was also recapitulated by subsequent knockdown of common tumor suppressors, whereas the impact of Tgfbr2 deletion was only partially recapitulated, illustrating genotype-dependent requirement of the pancreatic niche for tumorigenesis. Intriguingly, analysis of tumor-derived organoids revealed that KrasG12D-expressing cells with spontaneous deletion of wild-type Kras were positively selected and exhibited an aging-related mutation signature in nude mice, mirroring the pathogenesis of human PDA, and that the sphere-forming potential and orthotopic tumorigenicity in syngenic mice were significantly augmented. These observations highlighted the relevance of the subcutis of nude mice in promoting PDA development despite its ectopic nature. Taken together, pancreatic carcinogenesis could be considerably recapitulated with organoids, which would probably serve as a novel disease model.

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    Other Link： http://academic.oup.com/carcin/article-pdf/41/4/490/33396192/bgz122.pdf

  • AKKERMANSIA MUCINIPHILA AND BIFIDOBACTERIUM BIFIDUM G9-1: KEY PLAYERS IN SMALL INTESTINAL INJURY CAUSED BY THE COMBINATION OF ASPIRIN AND PROTON PUMP INHIBITORS

    Tsutomu Yoshihara, Yosuke Oikawa, Takayuki Kato, Takaomi Kessoku, Takashi Kobayashi, Shingo Kato, Noboru Misawa, Keiichi Ashikari, Akiko Fuyuki, Hidenori Ohkubo, Takuma Higurashi, Yoko Tateishi, Yoshiki Tanaka, Shunji Nakajima, Hiroshi Ohno, Koichiro Wada, Atsushi Nakajima

    GASTROENTEROLOGY   158 ( 6 )   S1158 - S1158   2020.5

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  • Effect of preventive closure of the frenulum after endoscopic papillectomy: A prospective pilot study. Reviewed International journal

    Koichi Kagawa, Kensuke Kubota, Yusuke Kurita, Yuri Takagi, Ken Ishii, Sho Hasegawa, Akito Iwasaki, Takamitsu Sato, Yuji Fujita, Shingo Kato, Seitaro Watanabe, Yusuke Sekino, Kunihiro Hosono, Atsushi Nakajima

    Journal of gastroenterology and hepatology   35 ( 3 )   374 - 379   2020.3

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    BACKGROUND AND AIM: The usefulness of preventive closure of the frenulum after endoscopic papillectomy (EP) could reduce bleeding. The feasibility and safety of clipping were evaluated in this prospective pilot study. METHODS: This study involved 40 consecutive patients who underwent preventive closure of the frenulum by clipping just after EP. The outcome data were compared with those of the previous 40 patients in whom no preemptive closure had been performed (no-closure group) (UMIN000014783). Additionally, the bleeding sites were examined. RESULTS: The clipping procedure was successful in all patients. As compared to the no-closure group, the rate of bleeding (P = 0.026) and period of hospital stay (P < 0.001) were significantly reduced in the closure group. There was no difference in the procedure time between the two groups. Furthermore, the incidence rates of pancreatitis and perforation were comparable in the two groups. The bleeding was noted in the frenulum area rather than at any other site in 90.9% of cases. CONCLUSION: Preventive closure of the frenulum after EP is an effective, safe, rational, and economical method to reduce the incidence of delayed bleeding, without prolonging the procedure time or increasing the risk of post-procedure pancreatitis perforation.

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  • ERCP困難な膵管狭窄に対するEUSガイド下膵管ドレナージの治療成績

    長谷川 翔, 窪田 賢輔, 栗田 裕介, 佐藤 高光, 加藤 真吾, 細野 邦広, 中島 淳

    日本消化器病学会関東支部例会プログラム・抄録集   358回   36 - 36   2020.2

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  • Three-dimensional analysis of pancreatic fat by fat-water magnetic resonance imaging provides detailed characterization of pancreatic steatosis with improved reproducibility. Reviewed International journal

    Shingo Kato, Akito Iwasaki, Yusuke Kurita, Jun Arimoto, Toh Yamamoto, Sho Hasegawa, Takamitsu Sato, Kento Imajo, Kunihiro Hosono, Noritoshi Kobayashi, Masato Yoneda, Takuma Higurashi, Kensuke Kubota, Daisuke Utsunomiya, Atsushi Nakajima

    PloS one   14 ( 12 )   e0224921   2019.12

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    BACKGROUND: Since pancreatic steatosis is reported as a possible risk factor for pancreatic cancer, the development of a non-invasive method to quantify pancreatic steatosis is needed. Proton density fat fraction (PDFF) measurement is a magnetic resonance imaging (MRI) based method for quantitatively assessing the steatosis of a region of interest (ROI). Although it is commonly used for quantification of hepatic steatosis, pancreatic PDFF can greatly vary depending on the ROI's location because of the patchy nature of pancreatic fat accumulation. In this study, we attempted to quantify pancreatic steatosis by fat-water MRI with improved reproducibility. METHODS: Using the MRI images of 159 patients with nonalcoholic fatty liver disease, we attempted to calculate the average PDFF of whole pancreas. We set ROIs covering the entire area of the pancreas appearing in every slice and calculated the average PDFF from all the voxels included in the pancreas. We named this average value as whole-pancreatic PDFF and evaluated the reproducibility of the measured values. In addition to whole-pancreatic PDFF, we measured the average PDFF of the pancreatic head (head-PDFF) and that of the pancreatic body plus tail separately and analyzed their correlation with the clinical characteristics of the patients. RESULTS: The mean inter-examiner coefficient of variation of the whole-pancreatic PDFF was 11.39%. The whole-pancreatic PDFF was correlated with age (p = 0.039), body mass index (p = 0.0093) and presence/absence of diabetes (p = 0.0055). The serum level of low-density lipoprotein cholesterol was inversely correlated with the head-PDFF. CONCLUSION: We developed a new measurement method of the pancreatic PDFF with greater reproducibility. Using this method, we characterized pancreatic steatosis in detail. This novel measurement method allows accurate estimation of the severity of pancreatic steatosis and is therefore useful for the detailed characterization of pancreatic steatosis.

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  • CA19-9 as a therapeutic target in pancreatitis. Reviewed International journal

    Shingo Kato, Kazufumi Honda

    Annals of translational medicine   7 ( Suppl 8 )   S318   2019.12

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  • Safety of Cold Snare Polypectomy in Patients Receiving Treatment with Antithrombotic Agents. Reviewed International journal

    Jun Arimoto, Hideyuki Chiba, Keiichi Ashikari, Ryo Fukui, Hideyuki Anan, Jun Tachikawa, Takuma Suto, Naoya Kawano, Toshihiro Niikura, Hiroki Kuwabara, Michiko Nakaoka, Shingo Kato, Tomonori Ida, Taiki Morohashi, Tohru Goto, Atsushi Nakajima

    Digestive diseases and sciences   64 ( 11 )   3247 - 3255   2019.11

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    BACKGROUND: With the aging of the population and rising incidence of thromboembolic events, the clinical use of antithrombotic agents is also increasing. There are few reports yet on the management of antithrombotic agent use in patients undergoing cold snare polypectomy (CSP). AIMS: The aim of this study was to evaluate whether continued administration of antithrombotic agents in patients undergoing CSP would be associated with an increased rate of delayed post-polypectomy bleeding (DPPB). METHODS: A total of 1177 colorectal polyps in 501 patients were resected at Omori Red Cross Hospital between October 2017 and March 2018. The polyps were divided into two groups depending on whether the patients received antithrombotic agent treatment or not: the antithrombotic group (911 polyps) and the no-antithrombotic group (266 polyps). RESULTS: Among the 1177 polyp resections, there was no case of DPPB, including in the antithrombotic group. Immediate bleeding occurred in a total of 63 (5.4%) cases. Polyp location in the rectum (OR (95% CI) 2.64 (1.223-5.679); p = 0.013), polyp size ≥ 6 mm (OR (95% CI) 4.64 (2.719-7.933); p < 0.001), polypoid growth pattern (OR (95% CI) 2.78 (1.607-4.793); p < 0.001), and antithrombotic agent use (OR (95% CI) 2.98 (1.715-5.183); p < 0.001) were identified as significant risk factors of immediate bleeding. CONCLUSIONS: Continued use of antithrombotic agents does not increase the risk of DPPB, even in those receiving multiple antithrombotic agents. Thus, it is safe to perform CSP even in multiple agent users. Prospective, randomized studies are necessary to confirm our results.

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  • Clinical features of early-stage possible Behçet’s disease patients with a variant-type major organ involvement in Japan

    Takeharu Suzuki, Nobuyuki Horita, Masaki Takeuchi, Takehito Ishido, Yuki Mizuki, Ryuta Mizuki, Tatsukata Kawagoe, Etsuko Shibuya, Kentaro Yuta, Takahiro Yamane, Takahiko Hayashi, Akira Meguro, Mizuho Ishido, Kaoru Minegishi, Ryusuke Yoshimi, Yohei Kirino, Shingo Kato, Jun Arimoto, Takeshi Fukumoto, Yoshiaki Ishigatsubo, Michiko Kurosawa, Mitsuhiro Takeno, Takeshi Kaneko, Nobuhisa Mizuki

    Modern Rheumatology   29 ( 4 )   640 - 646   2019.7

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    DOI： 10.1080/14397595.2018.1494501

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  • Clinical features of isolated proximal-type immunoglobulin G4-related sclerosing cholangitis. Reviewed International journal

    Yuri Takagi, Kensuke Kubota, Takuya Takayanagi, Yusuke Kurita, Ken Ishii, Sho Hasegawa, Akito Iwasaki, Takamitsu Sato, Yuji Fujita, Shingo Kato, Koichi Kagawa, Seitaro Watanabe, Yusuke Sekino, Kunihiro Hosono, Nobuyuki Matsuhashi, Shoji Yamanaka, Toshiyasu Iwao, Koji Yoshida, Atsushi Nakajima

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   31 ( 4 )   422 - 430   2019.7

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    BACKGROUND AND AIM: Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) presents as isolated proximal-type sclerosing cholangitis (i-SC). The present study sought to clarify the imaging differences between i-SC and Klatskin tumor. Differences between i-SC and IgG4-SC associated with autoimmune pancreatitis (AIP-SC) were also studied. METHODS: Differentiating factors between i-SC and Klatskin tumor were studied. Serum IgG4 level, CA19-9 level, computed tomography (CT) findings, cholangiography findings (symmetrical smooth long stricture extending into the upper bile duct [SSLS]), endosonographic features (continuous symmetrical mucosal lesion to the hilar part [CSML]), endoscopic biopsy results, treatment, relapse, and survival were also compared between patients with i-SC and those with AIP-SC. RESULTS: For a differential diagnosis between i-SC (N = 9) and Klatskin tumor (N = 47), the cut-off value of serum IgG4 level was 150 mg/dL (sensitivity, 0.857, specificity, 0.966). Logistic regression analysis indicated that serum IgG4 level, presence of SSLS, presence of CSML, and presence of swollen ampulla are independent factor for identifying i-SC. Relapse rate was significantly higher in the IgG4-SC with AIP group than in the i-SC group (log rank, P = 0.046). CONCLUSION: Isolated proximal-type sclerosing cholangitis presents as a nodular lesion with SSLS and/or CSML mimicking a Klatskin tumor. Those endoscopic features might provide a diagnostic clue for i-SC. i-SC is likely to have a more favorable prognosis than IgG4-SC with AIP.

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  • 胆膵領域におけるelasticity imagingの役割 超音波内視鏡下エラストグラフィーを用いた膵実質硬度評価の試み

    佐藤 高光, 細野 邦広, 加藤 真吾, 長谷川 翔, 栗田 裕介, 窪田 賢輔, 中島 淳

    超音波医学   46 ( Suppl. )   S336 - S336   2019.4

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  • Increased levels of bile acid in feces plays an important role in pathophysiology of non-alcoholic steatohepatitis

    Takaomi Kessoku, Takashi Kobayashi, Kento Imajo, Yasushi Honda, Yuji Ogawa, Takuma Higurashi, Shingo Kato, Masato Yoneda, Yousuke Oikawa, Yoshiki Tanaka, Shunji Nakajima, Haruki Usuda, Koichiro Wada, Satoru Saito, Atsushi Nakajima

    JOURNAL OF HEPATOLOGY   70 ( 1 )   E534 - E534   2019.4

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  • Efficacy, safety, and tolerability of lubiprostone for the treatment of non-alcoholic fatty liver disease: The LUBIPRONE, double-blind, randomized, placebo-controlled, phase II study

    Takaomi Kessoku, Kento Imajo, Yuji Ogawa, Takashi Kobayashi, Yasushi Honda, Takayuki Kato, Wataru Tomeno, Shingo Kato, Takuma Higurashi, Masato Yoneda, Hiroyuki Kirikoshi, Kazumi Kubota, Masataka Taguri, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Satoru Saito, Atsushi Nakajima

    JOURNAL OF HEPATOLOGY   70 ( 1 )   E1 - E1   2019.4

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  • The ocular involvement did not accompany with the genital ulcer or the gastrointestinal symptoms at the early stage of Behçet’s disease

    Akiko Suwa, Nobuyuki Horita, Takehito Ishido, Masaki Takeuchi, Tatsukata Kawagoe, Etsuko Shibuya, Takahiro Yamane, Takahiko Hayashi, Akira Meguro, Mizuho Ishido, Kaoru Minegishi, Ryusuke Yoshimi, Yohei Kirino, Shingo Kato, Jun Arimoto, Takeshi Fukumoto, Yoshiaki Ishigatsubo, Michiko Kurosawa, Takeshi Kaneko, Mitsuhiro Takeno, Nobuhisa Mizuki

    Modern Rheumatology   29 ( 2 )   357 - 362   2019.3

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    DOI： 10.1080/14397595.2018.1457424

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  • Multicenter experience with large panel next-generation sequencing in patients with advanced solid cancers in Japan. Reviewed International journal

    Shingo Kato, Takuo Hayashi, Yoshiyuki Suehara, Haruka Hamanoue, Shoji Yamanaka, Yasushi Ichikawa, Takuma Higurashi, Kenichi Ohashi, Shigeo Yamaguchi, Yumi Nozaki, Yasuhisa Terao, Tsuyoshi Saito

    Japanese journal of clinical oncology   49 ( 2 )   174 - 182   2019.2

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    Background: Application of next-generation DNA sequencing (NGS) has recently become increasingly common in the field of clinical oncology in several countries around the world. In Japan also, a system for applying NGS to routine clinical practice is gradually being established. During this process, we introduced in Japan the tumor-profiling MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets) assay. Methods: We present here our initial experience with the use of MSK-IMPACT in 68 patients selected from two institutions in Japan between June 2016 and October 2017. Results: MSK-IMPACT sequencing was successful and yielded results in specimens obtained from 64 of the 68 patients, representing an overall assay success rate of 94.1%. The top three cancer types tested were endometrial cancer (17.2%), pancreatic cancer (15.6%) and colorectal cancer (12.5%). Evaluation of the clinical actionability of the genetic alterations revealed that 25.0% of patients (n = 16) harbored at least one actionable alteration. However, enrolling the patients in a genomically matched clinical trial was difficult, mainly because most clinical trials are limited to tumors arising from a specific organ/site. One patient with microsatellite instability-high status, as determined by MSK-IMPACT, was treated with pembrolizumab and showed partial response. Conclusions: Although tumor profiling by NGS and administration of genomically matched therapy is a promising strategy, because of its high cost, we need to consider how we can fit it into the Japanese medical system. Towards this end, we believe that it is important to share our initial experience for furthering precision medicine in Japan.

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  • Palmitate-induced lipotoxicity is crucial for the pathogenesis of nonalcoholic fatty liver disease in cooperation with gut-derived endotoxin. Reviewed International journal

    Yuji Ogawa, Kento Imajo, Yasushi Honda, Takaomi Kessoku, Wataru Tomeno, Shingo Kato, Koji Fujita, Masato Yoneda, Satoru Saito, Yusuke Saigusa, Hideyuki Hyogo, Yoshio Sumida, Yoshito Itoh, Kosei Eguchi, Takeharu Yamanaka, Koichiro Wada, Atsushi Nakajima

    Scientific reports   8 ( 1 )   11365 - 11365   2018.7

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    Although previous studies have indicated important roles of palmitate, a saturated fatty acid, in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), it remains unclear how palmitate contributes to inflammation and fibrosis in the liver. Administration of palmitate in high fat diet (HFD)-fed but not basal diet (BD)-fed mice resulted in an increase in serum alanine aminotransferase (ALT) levels. Surprisingly, combined administration of very low dose lipopolysaccharide in palmitate-treated mice led to a marked increase in serum ALT levels despite BD-fed conditions. Administration of palmitate alone in BD-fed mice caused inflammatory cell infiltration and liver fibrosis mediated by the toll-like receptor 4 pathway without ALT elevation. In addition, a significant correlation between serum free fatty acid levels and liver fibrosis stage was observed in patients with NAFLD. These results indicate that palmitate may play crucial roles in the pathogenesis of NAFLD in the presence of gut-derived endotoxin.

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  • Efficacy, safety, and tolerability of lubiprostone for the treatment of non-alcoholic fatty liver disease in adult patients with constipation: The LUBIPRONE, double-blind, randomised, placebo-controlled study design. Reviewed International journal

    Takaomi Kessoku, Kento Imajo, Takashi Kobayashi, Yasushi Honda, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Shingo Kato, Takuma Higurashi, Masato Yoneda, Hiroyuki Kirikoshi, Kazumi Kubota, Masataka Taguri, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Satoru Saito, Atsushi Nakajima

    Contemporary clinical trials   69   40 - 47   2018.6

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    BACKGROUND: This paper reports the protocol of a randomised, double-blind, placebo-controlled study to test the efficacy, safety, and tolerability of lubiprostone (LUB) vs. placebo on suppressing gut permeability in non-alcoholic fatty liver disease (NAFLD) patients with constipation. NAFLD, including non-alcoholic steatohepatitis (NASH), is a common chronic liver disorder. Progression is associated with increased gut permeability and gut-derived endotoxins. Most NAFLD/NASH clinical trial drugs aim to improve liver function or systemic metabolism. LUB is a type 2 chloride channel activator used as a laxative for the treatment of patients with constipation. LUB suppresses gut permeability induced by non-steroidal anti-inflammatory drugs in healthy volunteers and lowers blood endotoxin levels. There have been no clinical studies of LUB for NAFLD/NASH patients. METHODS: The study plans to enrol adult patients (20-85 years, planned enrolment, n = 150; planned sample size, n = 120) with NAFLD and constipation, alanine aminotransferase ≥40 IU/L, equivalent steatosis grade ≥1, and equivalent fibrosis stage <4 measured using non-invasive vibration-controlled transient elastography and magnetic resonance imaging. Participants will be randomly allocated into three groups: LUB 12 μg, LUB 24 μg, and a placebo group. RESULTS: The primary endpoint will be changes in alanine aminotransferase from baseline at 12 weeks. The main secondary endpoint will be changes in intestinal permeability from baseline at 12 weeks using the lactulose mannitol ratio. CONCLUSIONS: This study will determine whether LUB improves gut permeability in NAFLD patients with constipation. TRIAL REGISTRATION: This trial is registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN000026635).

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  • Risk factors for post-colorectal endoscopic submucosal dissection (ESD) coagulation syndrome: a multicenter, prospective, observational study. Reviewed International journal

    Jun Arimoto, Takuma Higurashi, Shingo Kato, Akiko Fuyuki, Hidenori Ohkubo, Takashi Nonaka, Yoshikazu Yamaguchi, Keiichi Ashikari, Hideyuki Chiba, Shungo Goto, Masataka Taguri, Takashi Sakaguchi, Kazuhiro Atsukawa, Atsushi Nakajima

    Endoscopy international open   6 ( 3 )   E342-E349 - E349   2018.3

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    Background and study aims:  Colorectal cancer (CRC) is one of the most common neoplasms and endoscopic submucosal dissection (ESD) is an effective treatment for early-stage CRC. However, it has been observed that patients undergoing ESD often complain of pain, even if ESD has been successfully performed. Risk factors for such pain still remain unknown. The aim of this study was to explore the risk factors for post-colorectal ESD coagulation syndrome (PECS). Patients and methods : This was a prospective multicenter observational trial (UMIN000016781) conducted in 106 of 223 patients who underwent ESD between March 2015 and April 2016. We investigated age, sex, tumor location, ESD operation time, lesion size, duration of hospitalization, and frequency of PECS. We defined PECS as local abdominal pain (evaluated on a visual analogue scale) in the region corresponding to the site of the ESD that occurred within 4 days of the procedure. Results : PECS occurred in 15/106 (14.2 %), and 10 were women ( P  = 0.01, OR: 7.74 [1.6 - 36.4]), 7 had lesions in the cecum ( P  < 0.001, OR: 20.6 [3.7 - 115.2]), and 9 in whom ESD operation time was > 90 min ( P  = 0.002, OR: 10.3 [2.4 - 44.6]). Frequency of deviation from the prescribed clinical path was significantly higher (47 % [7/15] vs. 2 % [2/91], P  < 0.001, OR: 38.9 [6.9 - 219.6]), and hospital stay was significantly longer in the PECS group. . Conclusions : Female gender, location of lesion in the cecum, and ESD operation time > 90 minutes were significant risk factors independent of PECS. These findings are important to management of PECS. .

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  • Possible therapeutic application of targeting type II natural killer T cell-mediated suppression of tumor immunity Reviewed

    Shingo Kato, Jay A. Berzofsky, Masaki Terabe

    Frontiers in Immunology   9   314   2018.2

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  • Clinical manifestations of Behcet's disease depending on sex and age: results from Japanese nationwide registration Reviewed

    Takehito Ishido, Nobuyuki Horita, Masaki Takeuchi, Tatsukata Kawagoe, Etsuko Shibuya, Takahiro Yamane, Takahiko Hayashi, Akira Meguro, Mizuho Ishido, Kaoru Minegishi, Ryusuke Yoshimi, Yohei Kirino, Shingo Kato, Jun Arimoto, Yoshiaki Ishigatsubo, Mitsuhiro Takeno, Michiko Kurosawa, Takeshi Kaneko, Nobuhisa Mizuki

    RHEUMATOLOGY   56 ( 11 )   1918 - 1927   2017.11

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  • Effect of vonoprazan on the treatment of artificial gastric ulcers after endoscopic submucosal dissection: Prospective randomized controlled trial. Reviewed International journal

    Izumi Tsuchiya, Yuri Kato, Emiko Tanida, Yoshifumi Masui, Shingo Kato, Atsushi Nakajima, Motoyoshi Izumi

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   29 ( 5 )   576 - 583   2017.7

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  • Blockade of only TGF-β 1 and 2 is sufficient to enhance the efficacy of vaccine and PD-1 checkpoint blockade immunotherapy. Reviewed

    Terabe M, Robertson FC, Clark K, De Ravin E, Bloom A, Venzon DJ, Kato S, Mirza A, Berzofsky JA

    Oncoimmunology   6 ( 5 )   e1308616   2017

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  • 【Interventional EUSのすべて】EUSガイド下腹腔神経叢・神経節ブロック術 EUS-CPN/CGN

    窪田 賢輔, 栗田 裕介, 岩崎 暁人, 佐藤 高光, 加藤 真吾, 香川 幸一, 細野 邦広, 渡辺 誠太郎, 関野 雄典, 藤田 祐司, 石井 研, 長谷川 翔

    消化器内視鏡   28 ( 10 )   1685 - 1690   2016.10

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    これまで、癌性疼痛や腰部椎間板ヘルニアに伴う腰痛に対して、麻酔科、整形外科専門医によりX線透視下に、患者背側からawakeのまま神経ブロックがブラインドで行われてきた。一方、超音波内視鏡ガイド下腹腔神経ブロック術は鎮静下で、超音波内視鏡ガイド下穿刺吸引法(EUS-FNA)と同様、苦痛なく安全に施行可能で、有効性の高い手技として注目されている。癌性疼痛については、WHOラダーに沿って鎮痛薬はできる限り内服で少量から始め、疼痛が消える量に漸増し、なるべく定時処方で、必要に応じて鎮痛補助薬の併用も考慮すべきとされている。ほとんどの疼痛はWHOラダーに沿った治療でコントロール可能であるが、麻薬を希望しない、または麻薬不耐性などの場合に本法は有効である。超音波内視鏡ガイド下腹腔神経ブロック術には、腹腔神経叢ブロック(EUS-CPB)と神経節ブロック(EUS-CGN)がある。現状では、EUS-CPNはWHOの疼痛コントロールのstep3の選択肢の一つとして施行されている。(著者抄録)

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  • 術後再建腸管の狭窄に対するシングルバルーン内視鏡による金属ステントの有用性

    岩崎 暁人, 栗田 裕介, 長谷川 翔, 佐藤 高光, 藤田 祐司, 細野 邦広, 加藤 真吾, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   58 ( Suppl.2 )   1940 - 1940   2016.10

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  • 良性胆道狭窄・術前胆道ドレナージに対する超音波内視鏡下胆道ドレナージ術の適応

    佐藤 高光, 栗田 裕介, 長谷川 翔, 岩崎 暁人, 藤田 裕司, 加藤 真吾, 細野 邦広, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   58 ( Suppl.2 )   1939 - 1939   2016.10

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  • Diagnostic test accuracy of glutamate dehydrogenase for Clostridium difficile: Systematic review and meta-analysis. Reviewed International journal

    Jun Arimoto, Nobuyuki Horita, Shingo Kato, Akiko Fuyuki, Takuma Higurashi, Hidenori Ohkubo, Hiroki Endo, Nonaka Takashi, Takeshi Kaneko, Atsushi Nakajima

    Scientific reports   6   29754 - 29754   2016.7

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  • Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis. Reviewed International journal

    Takaomi Kessoku, Kento Imajo, Yasushi Honda, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Shingo Kato, Hironori Mawatari, Koji Fujita, Masato Yoneda, Yoji Nagashima, Satoru Saito, Koichiro Wada, Atsushi Nakajima

    Scientific reports   6   22251 - 22251   2016.2

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  • The Selective SGLT2 Inhibitor Ipragliflozin Has a Therapeutic Effect on Nonalcoholic Steatohepatitis in Mice. Reviewed International journal

    Yasushi Honda, Kento Imajo, Takayuki Kato, Takaomi Kessoku, Yuji Ogawa, Wataru Tomeno, Shingo Kato, Hironori Mawatari, Koji Fujita, Masato Yoneda, Satoru Saito, Atsushi Nakajima

    PloS one   11 ( 1 )   e0146337   2016

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  • Vaginal type-II mucosa is an inductive site for primary CD8(+) T-cell mucosal immunity Reviewed

    Yichuan Wang, Yongjun Sui, Shingo Kato, Alison E. Hogg, Jason C. Steel, John C. Morris, Jay A. Berzofsky

    Nature Communications   6   6100   2015.1

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    DOI： 10.1038/ncomms7100

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  • Endoscopic treatment of postoperative benign bile duct stricture compared with malignant bile duct stricture. Reviewed International journal

    Noritoshi Kobayashi, Takamitsu Sato, Shingo Kato, Seitaro Watanabe, Kunihiro Hosono, Kensuke Kubota, Kazuhisa Takedaz, Itaru Endo, Atsushi Nakajima, Shin Maeda, Yasushi Ichikawa

    Hepato-gastroenterology   61 ( 134 )   1507 - 18   2014.9

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  • Positioning of nasobiliary tube using magnet-loaded catheters. Reviewed International journal

    Seitaro Watanabe, Takamitsu Sato, Shingo Kato, Kunihiro Hosono, Noritoshi Kobayashi, Atsushi Nakajima, Kensuke Kubota

    Endoscopy   45 ( 10 )   835 - 7   2013.10

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    DOI： 10.1055/s-0033-1344330

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  • beta-Mannosylceramide Activates Type I Natural Killer T Cells to Induce Tumor Immunity without Inducing Long-Term Functional Anergy Reviewed

    Jessica J. O'Konek, Shingo Kato, Satomi Takao, Liat Izhak, Zheng Xia, Petr Illarionov, Gurdyal S. Besra, Masaki Terabe, Jay A. Berzofsky

    CLINICAL CANCER RESEARCH   19 ( 16 )   4404 - 4411   2013.8

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    DOI： 10.1158/1078-0432.CCR-12-2169

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  • aPKCλ/ι is a beneficial prognostic marker for pancreatic neoplasms Reviewed

    Shingo Kato, Kazunori Akimoto, Yoji Nagashima, Hitoshi Ishiguro, Kensuke Kubota, Noritoshi Kobayashi, Kunihiro Hosono, Seitaro Watanabe, Yusuke Sekino, Takamitsu Sato, Kazunori Sasaki, Noboru Nakaigawa, Yoshinobu Kubota, Yoshiaki Inayama, Itaru Endo, Shigeo Ohno, Shin Maeda, Atsushi Nakajima

    Pancreatology   13 ( 4 )   360 - 368   2013.7

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    DOI： 10.1016/j.pan.2013.05.006

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  • 嚢腫状に拡張した下部胆管に認められた十二指腸乳頭部癌の1例

    藤田 祐司, 渡邉 誠太郎, 佐藤 高光, 加藤 真吾, 細野 邦広, 小林 規俊, 遠藤 格, 山中 正二, 窪田 賢輔

    胆道   27 ( 2 )   240 - 246   2013.5

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    症例は70歳女性。USで肝内胆管、総胆管の拡張を認めた。CTで下部胆管に造影効果を有する腫瘍を認めた。内視鏡で十二指腸乳頭部の口側隆起は球状に腫大し、開口部粘膜の潰瘍性病変と十二指腸粘膜の襞集中を認めた。胆管深部挿管は困難でありsuprapapillary incisionを施行した。ERCで胆管末端の嚢腫状拡張を認めた。EUS、IDUSでは胆管末端は12mm径の嚢腫状の拡張を認め、十二指腸乳頭部に腫瘍の筋層浸潤を認めた。乳頭部生検は腺癌であった。術前画像診断でAbから発生した浸潤癌と診断した。非共通管拡張型のCholedochoceleの合併も示唆された。手術施行されたが開腹時、肝臓に微小結節が多発していたため試験開腹のみとなった。(著者抄録)

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    Other Link： https://search.jamas.or.jp/default/link?pub_year=2013&ichushi_jid=J02149&link_issn=&doc_id=20130607100012&doc_link_id=%2Fdw1tando%2F2013%2F002702%2F012%2F0240-0246%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdw1tando%2F2013%2F002702%2F012%2F0240-0246%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • Needle-knife precut papillotomy with a small incision over a pancreatic stent improves the success rate and reduces the complication rate in difficult biliary cannulations. Reviewed

    Kensuke Kubota, Takamitsu Sato, Shingo Kato, Seitaro Watanabe, Kunihiro Hosono, Noritoshi Kobayashi, Kantaro Hisatomi, Nobuyuki Matsuhashi, Atsushi Nakajima

    Journal of hepato-biliary-pancreatic sciences   20 ( 3 )   382 - 8   2013.3

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  • Delicate Balance among Three Types of T Cells in Concurrent Regulation of Tumor Immunity Reviewed

    Liat Izhak, Elena Ambrosino, Shingo Kato, Stanley T. Parish, Jessica J. O'Konek, Hannah Weber, Zheng Xia, David Venzon, Jay A. Berzofsky, Masaki Terabe

    CANCER RESEARCH   73 ( 5 )   1514 - 1523   2013.3

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    DOI： 10.1158/0008-5472.CAN-12-2567

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  • Soluble CD14 levels reflect liver inflammation in patients with nonalcoholic steatohepatitis. Reviewed International journal

    Yuji Ogawa, Kento Imajo, Masato Yoneda, Takaomi Kessoku, Wataru Tomeno, Yoshiyasu Shinohara, Shingo Kato, Hironori Mawatari, Yuichi Nozaki, Koji Fujita, Hiroyuki Kirikoshi, Shin Maeda, Satoru Saito, Koichiro Wada, Atsushi Nakajima

    PloS one   8 ( 6 )   e65211   2013

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    BACKGROUND AIMS: Liver inflammation is a risk factor for the progression of nonalcoholic fatty liver disease (NAFLD). However, the diagnosis of liver inflammation is very difficult and invasive liver biopsy is still the only method to reliably detect liver inflammation. We previously reported that overexpression of CD14 in Kupffer cells may trigger the progression to nonalcoholic steatohepatitis (NASH) via liver inflammation following hyper-reactivity to low-dose lipopolysaccharide. Therefore, the aim of this study was to investigate the relationship between soluble type of CD14 (sCD14) and histological features in patients with NAFLD. METHODS: Our cohort consisted of 113 patients with liver biopsy-confirmed NAFLD and 21 age-matched healthy controls. Serum sCD14 levels were measured by an enzyme-linked immunosorbent assay. RESULTS: Serum sCD14 levels were significantly associated with diagnosis of NASH and the area under the receiver operator characteristic curve (AUROC) to distinguish between not NASH and NASH was 0.802. Moreover, serum sCD14 levels were significantly associated with the disease activity based on NAFLD activity score and hepatic CD14 mRNA expression, which is correlated with membrane CD14 (mCD14) expression, in patients with NAFLD. In multiple regression analysis, the serum sCD14 levels were independently associated with liver inflammation. The AUROC to distinguish between mild and severe liver inflammation in patients with NAFLD was 0.752. CONCLUSIONS: We found that serum sCD14 levels increased significantly with increasing liver inflammation grade in patients with NAFLD, reflecting increased hepatic CD14 expression. Serum sCD14 is a promising tool to predict the worsening of liver inflammation, and may offer a potential biomarker for evaluation of therapeutic effects in NAFLD.

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  • A novel scoring system for arterial invasion of pancreatic body and tail cancer based on multidetector row computed tomography and biomarkers Reviewed

    Seitaro Watanabe, Noritoshi Kobayashi, Kensuke Kubota, Takamitsu Sato, Shingo Kato, Kunihiro Hosono, Takeshi Shimamura, Yoshiaki Inayama, Atsushi Nakajima, Itaru Endo

    Pancreatology   13 ( 2 )   161 - 169   2013

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    DOI： 10.1016/j.pan.2012.12.364

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  • Collapsin response mediator protein 4 expression is associated with liver metastasis and poor survival in pancreatic cancer Reviewed

    Yukihiko Hiroshima, Fumio Nakamura, Hiroshi Miyamoto, Ryutaro Mori, Koichi Taniguchi, Ryusei Matsuyama, Hirotoshi Akiyama, Kuniya Tanaka, Yasushi Ichikawa, Shingo Kato, Noritoshi Kobayashi, Kensuke Kubota, Yoji Nagashima, Yoshio Goshima, Itaru Endo

    Annals of Surgical Oncology   20 ( 3 )   S369 - S378   2013

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    DOI： 10.1245/s10434-012-2491-3

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  • Number of aberrant crypt foci in the rectum is a useful surrogate marker of colorectal adenoma recurrence Reviewed

    Takashi Uchiyama, Hirokazu Takahashi, Hiroki Endo, Shingo Kato, Eiji Sakai, Kunihiro Hosono, Masato Yoneda, Masahiko Inamori, Yoshitaka Hippo, Hitoshi Nakagama, Atsushi Nakajima

    DIGESTIVE ENDOSCOPY   24 ( 5 )   353 - 357   2012.9

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    DOI： 10.1111/j.1443-1661.2012.01289.x

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  • Primary leiomyoma of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration

    Takamitsu Sato, Shingo Kato, Seitaro Watanabe, Kunihiro Hosono, Noritoshi Kobayashi, Atsushi Nakajima, Kensuke Kubota

    Digestive Endoscopy   24 ( 5 )   380 - 380   2012.9

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  • Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling Reviewed

    Kento Imajo, Koji Fujita, Masato Yoneda, Yuichi Nozaki, Yuji Ogawa, Yoshiyasu Shinohara, Shingo Kato, Hironori Mawatari, Wataru Shibata, Hiroshi Kitani, Kenichi Ikejima, Hiroyuki Kirikoshi, Noriko Nakajima, Satoru Saito, Shiro Maeyama, Sumio Watanabe, Koichiro Wada, Atsushi Nakajima

    CELL METABOLISM   16 ( 1 )   44 - 54   2012.7

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  • Capsule endoscopy with flexible spectral imaging color enhancement reduces the bile pigment effect and improves the detectability of small bowel lesions Reviewed

    Eiji Sakai, Hiroki Endo, Shingo Kato, Tetsuya Matsuura, Wataru Tomeno, Leo Taniguchi, Takashi Uchiyama, Yasuo Hata, Eiji Yamada, Hidenori Ohkubo, Takuma Higrashi, Kunihiro Hosono, Hirokazu Takahashi, Atsushi Nakajima

    BMC GASTROENTEROLOGY   12   83   2012.7

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  • Soluble CD14 are a Useful Hallmark of Liver Inflammation and Predictor for Progression of Fibrosis in NASH Reviewed

    Ogawa Yuji, Imajo Kento, Yoneda Masato, Shinohara Yoshiyasu, Kato Shingo, Mawatari Hironori, Nozaki Yuichi, Fujita Koji, Shibata Wataru, Kirikoshi Hiroyuki, Wada Koichiro, Nakajima Atsushi

    GASTROENTEROLOGY   142 ( 5 )   S1019   2012.5

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  • Relationship Between the Plasma Concentrations of Free Choline and Parameters of Adiposity and Histological Findings in Patients With Nonalcoholic Fatty Liver Disease. a Multicenter Study in Japan Reviewed

    Imajo Kento, Yoneda Masato, Fujita Koji, Nozaki Yuichi, Ogawa Yuji, Shinohara Yoshiyasu, Kato Shingo, Mawatari Hironori, Shibata Wataru, Kirikoshi Hiroyuki, Wada Koichiro, Saito Satoru, Nakajima Atsushi

    GASTROENTEROLOGY   142 ( 5 )   S1016   2012.5

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  • Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization? Reviewed

    Hiroyuki Kirikoshi, Masato Yoneda, Hironori Mawatari, Koji Fujita, Kento Imajo, Shingo Kato, Kaori Suzuki, Noritoshi Kobayashi, Kensuke Kubota, Shin Maeda, Atsushi Nakajima, Satoru Saito

    WORLD JOURNAL OF GASTROENTEROLOGY   18 ( 16 )   1933 - 1939   2012.4

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  • Endoscopic ultrasonographic findings predict the risk of carcinoma in branch duct intraductal papillary mucinous neoplasms of the pancreas Reviewed

    Noritoshi Kobayashi, Kazuya Sugimori, Takeshi Shimamura, Kunihiro Hosono, Seitaro Watanabe, Shingo Kato, Michio Ueda, Itaru Endo, Yoshiaki Inayama, Shin Maeda, Atsushi Nakajima, Kensuke Kubota

    PANCREATOLOGY   12 ( 2 )   141 - 145   2012.3

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  • Early effects of oral administration of omeprazole and roxatidine on intragastric pH Reviewed

    Hiroshi Iida, Shingo Kato, Yusuke Sekino, Eiji Sakai, Takashi Uchiyama, Hiroki Endo, Kunihiro Hosono, Yasunari Sakamoto, Koji Fujita, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Chikako Tokoro, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Kensuke Kubota, Eiji Gotoh, Shin Maeda, Atsushi Nakajima, Masahiko Inamori

    JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B   13 ( 1 )   29 - 34   2012.1

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  • Imaging Findings of Pancreatic Cystic Lesions in von Hippel-Lindau Disease Reviewed

    Noritoshi Kobayashi, Takamitsu Sato, Shingo Kato, Seitaro Watanabe, Kunihiro Hosono, Takeshi Shimamura, Hiroshi Iida, Hiroki Endo, Tomoko Koide, Hirokazu Takahashi, Masato Yoneda, Wataru Shibata, Yasunobu Abe, Masahiko Inamori, Hiroyuki Kirikoshi, Satoru Saito, Shin Maeda, Atsushi Nakajima, Kensuke Kubota

    INTERNAL MEDICINE   51 ( 11 )   1301 - 1307   2012

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  • Semaphorin 4D, a lymphocyte semaphorin, enhances tumor cell motility through binding its receptor, plexinB1, in pancreatic cancer Reviewed

    Shingo Kato, Kensuke Kubota, Takeshi Shimamura, Yoshiyasu Shinohara, Noritoshi Kobayashi, Seitaro Watanabe, Masato Yoneda, Masahiko Inamori, Fumio Nakamura, Hitoshi Ishiguro, Noboru Nakaigawa, Yoji Nagashima, Masataka Taguri, Yoshinobu Kubota, Yoshio Goshima, Satoshi Morita, Itaru Endo, Shin Maeda, Atsushi Nakajima, Hitoshi Nakagama

    CANCER SCIENCE   102 ( 11 )   2029 - 2037   2011.11

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  • Effective treatment for duodenal variceal bleeding using endoscopic ligation Reviewed

    Yutaka Kawakami, Hirokazu Takahashi, Shingo Kato, Takashi Uchiyama, Hironori Mawatari, Hiroshi Iida, Masahiko Inamori, Yasunobu Abe, Atsushi Nakajima

    Hepato-Gastroenterology   58 ( 112 )   2024 - 2025   2011.11

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  • Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm Reviewed

    Eiji Sakai, Hirokazu Takahashi, Shingo Kato, Takashi Uchiyama, Kunihiro Hosono, Hiroki Endo, Shin Maeda, Masato Yoneda, Masataka Taguri, Atsushi Nakajima

    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION   20 ( 9 )   1918 - 1924   2011.9

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    DOI： 10.1158/1055-9965.EPI-11-0104

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  • Rectal carcinoma with metachronous metastasis to the extrahepatic bile duct without liver tumor Reviewed

    Noritoshi Kobayashi, Ryu Kobayashi, Shingo Kato, Seitaro Watanabe, Takashi Uchiyama, Takeshi Shimamura, Kensuke Kubota, Shin Maeda, Atsushi Nakajima, Yasushi Ichikawa, Hisashi Oshiro, Itaru Endo

    Clinical Journal of Gastroenterology   4 ( 4 )   278 - 282   2011.8

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  • Factors predictive of relapse and spontaneous remission of autoimmune pancreatitis patients treated/not treated with corticosteroids Reviewed

    Kensuke Kubota, Seitaro Watanabe, Takashi Uchiyama, Shingo Kato, Yusuke Sekino, Kaori Suzuki, Hironori Mawatari, Hiroshi Iida, Hiroki Endo, Koji Fujita, Masato Yoneda, Hirokazu Takahashi, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Satoru Saito, Kazuya Sugimori, Kantaro Hisatomi, Nobuyuki Matsuhashi, Hirotaka Sato, Emiko Tanida, Takashi Sakaguchi, Nobutaka Fujisawa, Atsushi Nakajima

    JOURNAL OF GASTROENTEROLOGY   46 ( 6 )   834 - 842   2011.6

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  • Usefulness of endoscopic biopsy using FOXP3(+) Treg up-regulation in the duodenal papilla in the differential diagnosis between autoimmune pancreatitis and pancreatic cancer Reviewed

    Kensuke Kubota, Shingo Kato, Seitaro Watanabe, Koji Fujita, Masato Yoneda, Hirokazu Takahashi, Masahiko Inamori, Takeshi Shimamura, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Satoru Saito, Kantaro Hisatomi, Nobuyuki Matsuhashi, Atsushi Nakajima

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   18 ( 3 )   414 - 421   2011.5

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  • Change of Gastric Emptying With Chewing Gum: Evaluation Using a Continuous Real-Time C-13 Breath Test (BreathID System) Reviewed

    Yasunari Sakamoto, Shingo Kato, Yusuke Sekino, Eiji Sakai, Takashi Uchiyama, Hiroshi Iida, Kunihiro Hosono, Hiroki Endo, Koji Fujita, Tomoko Koide, Hirokazu Takahashi, Masato Yoneda, Chikako Tokoro, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Kensuke Kubota, Shin Maeda, Atsushi Nakajima, Masahiko Inamori

    JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY   17 ( 2 )   174 - 179   2011.4

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  • Complications of the treatment of endoscopic biliary strictures developing after liver transplantation Reviewed

    Noritoshi Kobayashi, Kensuke Kubota, Takeshi Shimamura, Seitaro Watanabe, Shingo Kato, Kaori Suzuki, Takashi Uchiyama, Shin Maeda, Kazuhisa Takeda, Atsushi Nakajima, Itaru Endo

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   18 ( 2 )   202 - 210   2011.3

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    DOI： 10.1007/s00534-010-0330-0

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  • Effects of Domperidone on Gastric Emptying: A Crossover Study Using a Continuous Real-Time C-13 Breath Test (BreathID System) Reviewed

    Yasunari Sahamoto, Shingo Kato, Yusuke Sehino, Eiji Sakai, Takashi Uchiyama, Hiroshi Iida, Kunihiro Hosono, Hiroki Endo, Koji Fujita, Tomoho Koide, Hirokazu Takahashi, Masato Yoneda, Chikako Tokoro, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Kensuhe Kubota, Shin Maeda, Atsushi Nakajima, Masahiko Inamori

    HEPATO-GASTROENTEROLOGY   58 ( 106 )   637 - 641   2011.3

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  • Liver abscess caused by periodontal bacterial infection with Fusobacterium necrophorum Reviewed

    Masato Yoneda, Shingo Kato, Hironori Mawatari, Hiroyuki Kirikoshi, Kento Imajo, Koji Fujita, Hiroki Endo, Hirokazu Takahashi, Masahiko Inamori, Noritoshi Kobayashi, Kensuke Kubota, Satoru Saito, Iwai Tohnai, Kei Watanuki, Koichiro Wada, Shin Maeda, Atsushi Nakajima

    Hepatology Research   41 ( 2 )   194 - 196   2011.2

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    DOI： 10.1111/j.1872-034X.2010.00748.x

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  • DISCRIMINATION BETWEEN SCLEROSING CHOLANGITIS-ASSOCIATED AUTOIMMUNE PANCREATITIS AND PRIMARY SCLEROSING CHOLANGITIS, CANCER USING INTRADUCTAL ULTRASONOGRAPHY Reviewed

    Kensuke Kubota, Shingo Kato, Takashi Uchiyama, Seitaro Watanabe, Yuich Nozaki, Koji Fujita, Masato Yoneda, Masahiko Inamori, Takeshi Shimamura, Yasunobu Abe, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Satoru Saito, Atsushi Nakajima

    DIGESTIVE ENDOSCOPY   23 ( 1 )   10 - 16   2011.1

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    DOI： 10.1111/j.1443-1661.2010.01039.x

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  • Capsule Endoscopic Evaluation of Eosinophilic Enteritis before and after Treatment Reviewed

    Hiroki Endo, Kunihiro Hosono, Masahiko Inamori, Shingo Kato, Takashi Uchiyama, Hiroshi Iida, Yasunari Sakamoto, Koji Fujita, Hirokazu Takahashi, Tomoko Koide, Masato Yoneda, Chikako Tokoro, Yasunobu Abe, Kensuke Kubota, Satoru Saito, Kiyotaka Nagahama, Yoshiaki Inayama, Atsushi Nakajima

    DIGESTION   83 ( 1-2 )   134 - 135   2011

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  • A case of early carcinoma of the ampulla of Vater with skip lesion to the lower part of the common bile duct

    KATO Shingo, WATANABE Seitaro, ENDO Itaru, NAKAYAMA Takashi, INAYAMA Yoshiaki, KUBOTA Kensuke

    Tando   24 ( 4 )   617 - 623   2010.10

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    Cancer of ampulla of Vater showed a favorable prognosis compared to that with the other periampullaly lesions. Ampullary tumor tends to show local invasions without skip lesion along with the mucosa of extra-hepatic bile duct. We reported a first case with early ampullary cancer with skip lesion. Main and minor lesions existed together intermitted with normal mucosa of the bile duct. Regarding the detection for lesions, EUS had a diagnostic value. IDUS failed the accurate depth of the main lesion due to the inflammatory change. For a difficult case to diagnose, it was thought that 3D restructuring was necessary. There were no differences as for p53 immune reactivity in the resected specimen between the major and the minor tumors.<br>

    DOI： 10.11210/tando.24.617

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  • Nonalcoholic Fatty Liver Disease: US-based Acoustic Radiation Force Impulse Elastography Reviewed

    Masato Yoneda, Kaori Suzuki, Shingo Kato, Koji Fujita, Yuichi Nozaki, Kunihiro Hosono, Satoru Saito, Atsushi Nakajima

    RADIOLOGY   256 ( 2 )   640 - 647   2010.8

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    DOI： 10.1148/radiol.10091662

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  • RISKY ENDOSCOPIC ULTRASONOGRAPHY-GUIDED FINE-NEEDLE ASPIRATION FOR ASYMPTOMATIC RETROPERITONEAL TUMORS Reviewed

    Kensuke Kubota, Shingo Kato, Hironori Mawatari, Hiroshi Iida, Tomoyuki Akiyama, Koji Fujita, Masato Yoneda, Hirokazu Takahashi, Masahiko Inamori, Yasunobu Abe, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Satoru Saito, Atsushi Nakajima

    DIGESTIVE ENDOSCOPY   22 ( 2 )   144 - 146   2010.4

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    DOI： 10.1111/j.1443-1661.2010.00939.x

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  • Highly Active State of Autoimmune Pancreatitis With Mikulicz Disease Reviewed

    Kensuke Kubota, Tomoko Wada, Shingo Kato, Yuichi Mozaki, Masato Yoneda, Koji Fujita, Hirokazu Takahashi, Masahiko Inamori, Yasunobu Abe, Noritoshi Kobayashi, Hiroyuki Kirikoshi, Satoru Saito, Yoshiaki Inayama, Atsushi Nakajima

    PANCREAS   39 ( 1 )   E6 - E10   2010.1

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    DOI： 10.1097/MPA.0b013e3181bc119d

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  • FOXP3+ Regulatory T Cells and Tumoral Indoleamine 2,3-Dioxygenase Expression Predicts the Carcinogenesis of Intraductal Papillary Mucinous Neoplasms of the Pancreas Reviewed

    Noritoshi Kobayashi, Kensuke Kubota, Shingo Kato, Seitaro Watanabe, Takeshi Shimamura, Hiroyuki Kirikoshi, Satoru Saito, Michio Ueda, Itaru Endo, Yoshiaki Inayama, Shin Maeda, Atsushi Nakajima

    PANCREATOLOGY   10 ( 5 )   631 - 640   2010

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    DOI： 10.1159/000308966

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  • A mucosa-associated lymphoid tissue (MALT) lymphoma of the small intestine that was difficult to diagnose endoscopically Reviewed

    K. Yoneda, H. Takahashi, Y. Abe, M. Inamori, S. Kato, T. Uchiyama, H. Iida, H. Mawatari, K. Hosono, H. Endo, Y. Nozaki, T. Akiyama, K. Fujita, M. Yoneda, N. Kobayashi, H. Kirikoshi, K. Kubota, S. Saito, A. Nakajima

    Endoscopy   42 ( 2 )   E175   2010

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    DOI： 10.1055/s-0029-1214857

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  • Duodenal Gastrointestinal stromal tumor resembling a pancreatic neuroendocrine tumor in a patient with neurofibromatosis type I (von Recklinghausen's disease): A case report Reviewed

    Shinji Ohtake, Noritoshi Kobayashi, Shingo Kato, Kensuke Kubota, Itaru Endo, Yoshiaki Inayama, Atsushi Nakajima

    Journal of Medical Case Reports   4 ( 1 )   302   2010

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    DOI： 10.1186/1752-1947-4-302

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  • Esophagomediastinal and esophagobronchial fistulas associated with invasive aspergillosis Reviewed

    S. Kato, S. Inoue, M. Inamori, N. Miyazawa, T. Sato, N. Kobayashi, K. Mishina, M. Sasaki, Y. Ishigatsubo, A. Nakajima

    Endoscopy   42 ( 2 )   E48 - E49   2010

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    DOI： 10.1055/s-0029-1215414

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  • A duodenal mucosal lesion coming from pancreatic arteriovenous malformation Reviewed

    Shingo Kato, Noritoshi Kobayashi, Kensuke Kubota, Hiroyuki Kirikoshi, Seitaro Watanabe, Masami Ogawa, Masahiko Inamori, Takeshi Shimamura, Wataru Tomeno, Atsushi Nakajima, Kazuhisa Takeda, Itaru Endo, Yoji Nagashima, Ichiro Aoki

    Gastrointestinal Endoscopy   71 ( 7 )   1299 - 1300   2010

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    DOI： 10.1016/j.gie.2010.01.033

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  • Metastatic tumor in the colon from renal cell carcinoma Reviewed

    Yuichi Nozaki, Masahiko Inamori, Koji Fujita, Masato Yoneda, Shingo Kato, Takashi Uchiyama, Kaori Suzuki, Seitaro Watanabe, Hironori Mawatari, Hiroshi Iida, Kunihiro Hosono, Hiroki Endo, Yasunari Sakamoto, Kyoko Yoneda, Hirokazu Takahashi, Tomoko Koide, Chikako Tokoro, Noritoshi Kobayashi, Hiroyuki Kirikoshi, Takeshi Shimamura, Yasunobu Abe, Kensuke Kubota, Satoru Saito, Hisashi Oshiro, Yoshiaki Inayama, Atsushi Nakajima

    Internal Medicine   49 ( 7 )   709   2010

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    DOI： 10.2169/internalmedicine.49.3233

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  • Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease Reviewed

    Masato Yoneda, Kikuko Hotta, Yuichi Nozaki, Hiroki Endo, Takashi Uchiyama, Hironori Mawatari, Hiroshi Iida, Shingo Kato, Koji Fujita, Hirokazu Takahashi, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Masahiko Inamori, Yasunobu Abe, Kensuke Kubota, Satoru Saito, Shiro Maeyama, Koichiro Wada, Atsushi Nakajima

    LIVER INTERNATIONAL   29 ( 7 )   1078 - 1085   2009.8

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    DOI： 10.1111/j.1478-3231.2009.01988.x

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  • Identification of Cystatin SN as a novel tumor marker for colorectal cancer Reviewed

    Kyoko Yoneda, Hiroshi Iida, Hiroki Endo, Kunihiro Hosono, Tomoyuki Akiyama, Hirokazu Takahashi, Masahiko Inamori, Yasunobu Abe, Masato Yoneda, Koji Fujita, Shingo Kato, Yuichi Nozaki, Yasushi Ichikawa, Hiroshi Uozaki, Masashi Fukayama, Takahiro Shimamura, Tatsuhiko Kodama, Hiroyuki Aburatani, Chihiro Miyazawa, Keisuke Ishii, Naoki Hosomi, Mina Sagara, Masazumi Takahashi, Hideyuki Ike, Hiroaki Saito, Akihiko Kusakabe, Atsushi Nakajima

    INTERNATIONAL JOURNAL OF ONCOLOGY   35 ( 1 )   33 - 40   2009.7

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    DOI： 10.3892/ijo_00000310

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  • A PROPOSAL FOR DIFFERENTIATION BETWEEN EARLY- AND ADVANCED-STAGE AUTOIMMUNE PANCREATITIS BY ENDOSCOPIC ULTRASONOGRAPHY Reviewed

    Kensuke Kubota, Shingo Kato, Tomoyuki Akiyama, Koji Fujita, Masato Yoneda, Hirokazu Takahashi, Masami Ogawa, Masahiko Inamori, Yasunobu Abe, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Satoru Saito, Kantaro Hisatomi, Nobuyuki Matsuhashi, Atsushi Nakajima

    DIGESTIVE ENDOSCOPY   21 ( 3 )   162 - 169   2009.7

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    DOI： 10.1111/j.1443-1661.2009.00879.x

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  • Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway Reviewed

    Michiko Sugiyama, Hirokazu Takahashi, Kunihiro Hosono, Hiroki Endo, Shingo Kato, Kyoko Yoneda, Yuichi Nozaki, Koji Fujita, Masato Yoneda, Koichiro Wada, Hitoshi Nakagama, Atsushi Nakajima

    INTERNATIONAL JOURNAL OF ONCOLOGY   34 ( 2 )   339 - 344   2009.2

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    DOI： 10.3892/ijo_00000156

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  • Incidence of Small Bowel Injury Induced by Low-Dose Aspirin: A Crossover Study Using Capsule Endoscopy in Healthy Volunteers Reviewed

    Hiroki Endo, Kunihiro Hosono, Masahiko Inamori, Shingo Kato, Yuichi Nozaki, Kyoko Yoneda, Tomoyuki Akiyama, Koji Fujita, Hirokazu Takahashi, Masato Yoneda, Yasunobu Abe, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Kensuke Kubota, Satoru Saito, Nobuyuki Matsuhashi, Atsushi Nakajima

    DIGESTION   79 ( 1 )   44 - 51   2009

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    DOI： 10.1159/000204465

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  • Differentiating sclerosing cholangitis caused by autoimmune pancreatitis and primary sclerosing cholangitis according to endoscopic duodenal papillary features Reviewed

    Kensuke Kubota, Shingo Kato, Tomoyuki Akiyama, Masato Yoneda, Koji Fujita, Masami Ogawa, Masahiko Inamori, Noritoshi Kobayashi, Satoru Saito, Yukio Kakuta, Hisashi Ohshiro, Atsushi Nakajima

    GASTROINTESTINAL ENDOSCOPY   68 ( 6 )   1204 - 1208   2008.12

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    DOI： 10.1016/j.gie.2008.08.013

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  • Plasma Pentraxin3 is a Novel Marker for Nonalcoholic Steatohepatitis (NASH) Reviewed

    Masato Yoneda, Takashi Uchiyama, Shingo Kato, Hiroki Endo, Koji Fujita, Kyoko Yoneda, Hironori Mawatari, Hiroshi Iida, Hirokazu Takahashi, Hiroyuki Kirikoshi, Masahiko Inamori, Yuichi Nozaki, Noritoshi Kobayashi, Kensuke Kubota, Satoru Saito, Shiro Maeyama, Mina Sagara, Hiroyuki Aburatani, Tatsuhiko Kodama, Atsushi Nakajima

    BMC GASTROENTEROLOGY   8   53   2008.11

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    DOI： 10.1186/1471-230X-8-53

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  • THE COMPARISON OF THE TRANS-ARTERIAL CHEMOEMBOLIZATION (TACE) MONOTHERAPY AND THE COMBINED TACE WITH PERCUTANEOUS LOCAL THERAPY FOR HEPATOCELLULAR CARCINOMA (HCC)

    Hiroyuki Kirikoshi, Satoru Saito, Masato Yonedo, Koji Fujita, Hironori Mawatari, Yuichi Nozaki, Takashi Uchiyama, Tamon Ikeda, Kunihiro Hosono, Tomoyuki Akiyama, Hiroki Endo, Kyoko Yoneda, Masahiko Inamori, Hirokazu Takahashi, Hiroshi Iida, Shingo Kato, Yasunobu Abe, Noritoshi Kobayashi, Kensuke Kubota, Atsushi Nakajima

    HEPATOLOGY   48 ( 4 )   967A - 968A   2008.10

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  • Association between PPARGCIA polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD) Reviewed

    Masato Yoneda, Kikuko Hotta, Yuichi Nozaki, Hiroki Endo, Takashi Uchiyama, Hironori Mawatari, Hiroshi Iida, Shingo Kato, Kunihiro Hosono, Koji Fujita, Kyoko Yoneda, Hirokazu Takahashi, Hiroyuki Kirikoshi, Noritoshi Kobayashi, Masahiko Inamori, Yasunobu Abe, Kensuke Kubota, Satoru Saito, Shiro Maeyama, Koichiro Wada, Atsushi Nakajima

    BMC GASTROENTEROLOGY   8   27   2008.6

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    DOI： 10.1186/1471-230X-8-27

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  • High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH Reviewed

    Masato Yoneda, Hironori Mawatari, Koji Fujita, Hiroshi Iida, Kyoko Yonemitsu, Shingo Kato, Hirokazu Takahashi, Hiroyuki Kirikoshi, Masahiko Inamori, Yuichi Nozaki, Yasunobu Abe, Kensuke Kubota, Satoru Saito, Tomoyuki Iwasaki, Yasuo Terauchi, Shinji Togo, Shiro Maeyama, Atsushi Nakajima

    JOURNAL OF GASTROENTEROLOGY   42 ( 7 )   573 - 582   2007.7

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    DOI： 10.1007/s00535-007-2060-x

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  • Type IV collagen 7s domain is an independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stage Reviewed

    Masato Yoneda, Hironori Mawatari, Koji Fujita, Kyoko Yonemitsu, Shingo Kato, Hirokazu Takahashi, Hiroyuki Kirikoshi, Masahiko Inamori, Yuichi Nozaki, Yasunobu Abe, Kensuke Kubota, Satoru Saito, Tomoyuki Iwasaki, Yasuo Terauchi, Shinji Togo, Shiro Maeyama, Atsushi Nakajima

    JOURNAL OF GASTROENTEROLOGY   42 ( 5 )   375 - 381   2007.5

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    DOI： 10.1007/s00535-007-2014-3

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  • Inactivation of von Hippel-Lindau gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma Reviewed

    N Nakaigawa, M Yao, M Baba, S Kato, T Kishida, K Hattori, Y Nagashima, Y Kubota

    CANCER RESEARCH   66 ( 7 )   3699 - 3705   2006.4

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    DOI： 10.1158/0008-5472.CAN-05-0617

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  • Antiproliferative activity of angiotensin II receptor blocker through cross-talk between stromal and epithelial prostate cancer cells. Reviewed International journal

    Hiroji Uemura, Hitoshi Ishiguro, Yoji Nagashima, Takeshi Sasaki, Noboru Nakaigawa, Hisashi Hasumi, Shingo Kato, Yoshinobu Kubota

    Molecular cancer therapeutics   4 ( 11 )   1699 - 709   2005.11

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    We showed previously that angiotensin II activated the proliferation of prostate cancer cells and that angiotensin II receptor blockers (ARB) could inhibit it. Here, we investigated whether angiotensin II exerts mitogenic effects on the cross-talk between stromal and cancer cells and whether an ARB can inhibit tumor growth through actions on stromal cells. Cell proliferation and interleukin-6 secretion of prostate stromal PrSC cells stimulated with angiotensin II, tumor necrosis factor-alpha, or epidermal growth factor were examined in the absence and presence of ARB. We examined the effect of ARB on mitogen-activated protein kinase (MAPK) phosphorylation of PrSC and PC-3 cells treated with conditioned medium of PrSC cells and determined the effect of ARB on tumor growth induced by paracrine factors from PrSC cells. Angiotensin II activated the cell proliferation and interleukin-6 secretion of PrSC cells, and ARB inhibited it. Angiotensin II, tumor necrosis factor-alpha, or epidermal growth factor induced MAPK phosphorylation in PrSC cells, and this phosphorylation was inhibited by ARB. Conditioned medium of PrSC cells with angiotensin II activated MAPK phosphorylation in PC-3 cells, and ARB-treated conditioned medium of PrSC cells inhibited it. The tumor growth and angiogenesis of a mixture of PC-3 with PrSC were inhibited by ARB administration, whereas those of PC-3 xenografts were not inhibited. ARB exerted an antiproliferative effect on prostate cancer through paracrine factors from stromal cells. Because prostate stromal cells are thought to be involved in the initiation and development of prostate cancer, the present data suggest the possibility that ARBs are a novel therapeutic class of agents for prostate cancer.

    DOI： 10.1158/1535-7163.MCT-04-0295

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  • 肝細胞癌の肝移植後再発に対して,がん遺伝子パネル検査にて有効薬剤の推奨を受けた一例

    室井 健太, 岩城 慶大, 小林 貴, 大谷 知宏, 野上 麻子, 加藤 真吾, 米田 正人, 中島 淳

    日本消化器病学会関東支部例会プログラム・抄録集   377回   36 - 36   2023.12

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  • EUS-BDの早期偶発症に関する因子

    佐藤 高光, 細野 邦広, 長谷川 翔, 栗田 裕介, 八木 伸, 鈴木 洸, 加藤 真吾, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   64 ( Suppl.2 )   2118 - 2118   2022.10

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  • 悪性肝門部狭窄に対するステント予定交換により安定した治療を目指す

    佐藤 高光, 細野 邦広, 窪田 賢輔, 長谷川 翔, 栗田 裕介, 八木 伸, 鈴木 洸, 加藤 真吾, 佐藤 元一, 中島 淳

    Gastroenterological Endoscopy   64 ( Suppl.1 )   770 - 770   2022.4

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  • 胆管空腸吻合術後の肝内結石症に対する完全切石Strategy

    佐藤 高光, 細野 邦広, 長谷川 翔, 栗田 裕介, 八木 伸, 加藤 真吾, 窪田 賢輔, 中島 淳

    Gastroenterological Endoscopy   63 ( Suppl.2 )   2078 - 2078   2021.10

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  • 肝移植後胆管狭窄の現状と治療についての検討

    鈴木 洸, 栗田 裕介, 長谷川 翔, 佐藤 高光, 加藤 真吾, 細野 邦広, 窪田 賢輔, 中島 淳

    日本消化器病学会雑誌   118 ( 臨増大会 )   A782 - A782   2021.10

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  • 膵癌治療(ステント) 膵管空腸吻合術後狭窄に対する内視鏡治療の長期成績

    佐藤 高光, 細野 邦広, 長谷川 翔, 栗田 裕介, 八木 伸, 加藤 真吾, 窪田 賢輔, 中島 淳

    膵臓   36 ( 3 )   A295 - A295   2021.8

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  • ロング型シングルバルーンを基盤とした胆管空腸吻合術後の内視鏡Management

    佐藤 高光, 細野 邦広, 窪田 賢輔, 長谷川 翔, 栗田 裕介, 八木 伸, 加藤 真吾, 中島 淳

    胆道   35 ( 3 )   466 - 466   2021.8

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  • 高齢者消化器がん化学療法〜高齢者のがん治療を安全・効果的に遂行するための取り組み 切除不能進行膵癌において、サルコペニアの有無はFOLFILINOX導入の判断指標になりえる

    鈴木 洸, 栗田 裕介, 長谷川 翔, 佐藤 高光, 加藤 真吾, 細野 邦広, 小林 規俊, 窪田 賢輔, 中島 淳

    日本高齢消化器病学会誌   24 ( 1 )   119 - 119   2021.7

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  • EUS-BD関連偶発症の包括的検討 より安全な手技を目指して

    佐藤 高光, 細野 邦広, 八木 伸, 栗田 裕介, 長谷川 翔, 加藤 真吾, 窪田 賢輔, 中島 淳

    Gastroenterological Endoscopy   63 ( Suppl.1 )   931 - 931   2021.4

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  • 術後再建腸管に合併した胆管結石に対する包括的治療戦略

    長谷川 翔, 細野 邦広, 中島 淳, 八木 伸, 栗田 裕介, 佐藤 高光, 加藤 真吾, 窪田 賢輔

    日本消化器病学会雑誌   118 ( 臨増総会 )   A326 - A326   2021.3

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  • EFFICACY AND SAFETY OF LUBIPROSTONE TREATMENT FOR NON-ALCOHOLIC FATTY LIVER DISEASE WITH ADVANCED FIBROSIS: A POST-HOC ANALYSIS OF THE LUBIPRONE RANDOMIZED TRIAL.

    Takaomi Kessoku, Takashi Kobayashi, Yuki Kasai, Anna Ozaki, Michihiro Iwaki, Yasushi Honda, Yuji Ogawa, Kento Imajo, Shingo Kato, Takuma Higurashi, Masato Yoneda, Kazumi Kubota, Masataka Taguri, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Satoru Saito, Atsushi Nakajima

    HEPATOLOGY   72   1017 - 1017   2020.11

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  • 抗腫瘍製剤スクリーニングのための膵癌患者モデルの開発

    加藤 真吾, 鈴木 章浩, 松浦 哲也, 筆宝 義隆, 中島 淳

    日本癌学会総会記事   79回   OE2 - 3   2020.10

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  • EUS-BDの手技完遂における環境とは

    佐藤 高光, 栗田 裕介, 長谷川 翔, 加藤 真吾, 細野 邦広, 窪田 賢輔, 中島 淳

    Gastroenterological Endoscopy   62 ( Suppl.2 )   2168 - 2168   2020.10

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  • 術前放射線化学療法中の膵癌に対する内視鏡的胆道ドレナージの治療成績

    長谷川 翔, 栗田 裕介, 佐藤 高光, 細野 邦広, 加藤 真吾, 遠藤 格, 窪田 賢輔, 中島 淳

    Gastroenterological Endoscopy   62 ( Suppl.2 )   2165 - 2165   2020.10

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  • 難渋する胆道ドレナージの工夫 悪性肝門部胆管狭窄に対するEBDとEUS-HGSによるHybrid drainageの工夫

    佐藤 高光, 細野 邦広, 窪田 賢輔, 栗田 裕介, 長谷川 翔, 加藤 真吾, 中島 淳

    胆道   34 ( 3 )   431 - 431   2020.8

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  • ERCP困難な膵管狭窄に対するEUSガイド下膵管ドレナージの治療成績

    長谷川 翔, 窪田 賢輔, 栗田 裕介, 佐藤 高光, 加藤 真吾, 細野 邦広, 中島 淳

    日本消化器病学会関東支部例会プログラム・抄録集   358回   36 - 36   2020.2

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  • Establishment of orthotopic transplantation model of mouse gallbladder cancer organoid for development and efficacy evaluation of anti-tumor agents.

    Shingo Kato, Matsuura Tetsuya, Kurotaki Daisuke, Hippo Yoshitaka, Tamura Tomohiko, Nakajima Atsushi

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   93   3-O-122   2020

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    Gallbladder cancer (GBC) is relatively rare worldwide. For such rare cancer, the development of animal models is more important because it is difficult to develop optimal treatments in large-scale clinical trials. Additionally, considering that immunotherapy has emerged as a promising new modality of treatment for biliary tract cancers, to develop animal models that can analyze host immune response against cancer is becoming more important. Based on these backgrounds, we aimed to establish an orthotopic GBC mouse model. To reflect genetic alterations observed in human GBC, we first developed mouse gallbladder organoids with genetic alterations in the Kras and Trp53 genes. The knockout of Trp53 gene was introduced by CRISPR-Cas9 system. These GBC organoids could create a subcutaneous tumor in wild type mice with normal anti-tumor immunity. Additionally, an orthotopic transplant model was successfully established in wild type mice. The populations of the subsets of tumor-infiltrating immune cells were able to be analyzed in both the subcutaneous tumor model and the orthotopic transplant model. In both models, the percentage of CD8<sup>+</sup> T cells was slightly decreased and that of CD11b<sup>+</sup> Ly6G<sup>+</sup> cells significantly increased with tumor growth. Finally, the treatment of orthotopic transplant model by gemcitabine significantly decreased tumor volumes. In conclusion, we developed a novel GBC mouse model by which we can analyze tumor immune response and the efficacy of anti-tumor agents.

    DOI： 10.1254/jpssuppl.93.0_3-o-122

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  • 神経内分泌腫瘍に対する病理学的ソマトスタチン受容体発現からみたオクトレオスキャンの有用性

    長谷川 翔, 小林 規俊, 鈴木 洸, 春日 範樹, 佐藤 高光, 加藤 真吾, 細野 邦広, 窪田 賢輔, 市川 靖史, 中島 淳

    日本消化器病学会雑誌   116 ( 臨増大会 )   A861 - A861   2019.11

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  • Increased levels of bile acid in feces plays an important role in pathophysiology of non-alcoholic steatohepatitis

    Takaomi Kessoku, Takashi Kobayashi, Kento Imajo, Yasushi Honda, Yuji Ogawa, Takuma Higurashi, Shingo Kato, Masato Yoneda, Yousuke Oikawa, Yoshiki Tanaka, Shunji Nakajima, Haruki Usuda, Koichiro Wada, Satoru Saito, Atsushi Nakajima

    JOURNAL OF HEPATOLOGY   70 ( 1 )   E534 - E534   2019.4

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    DOI： 10.1016/S0618-8278(19)31055-2

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  • Efficacy, safety, and tolerability of lubiprostone for the treatment of non-alcoholic fatty liver disease: The LUBIPRONE, double-blind, randomized, placebo-controlled, phase II study

    Takaomi Kessoku, Kento Imajo, Yuji Ogawa, Takashi Kobayashi, Yasushi Honda, Takayuki Kato, Wataru Tomeno, Shingo Kato, Takuma Higurashi, Masato Yoneda, Hiroyuki Kirikoshi, Kazumi Kubota, Masataka Taguri, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Satoru Saito, Atsushi Nakajima

    JOURNAL OF HEPATOLOGY   70 ( 1 )   E1 - E1   2019.4

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    DOI： 10.1016/S0618-8278(19)30001-5

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  • in vitroモデルが明らかにするマウス膵管発がんにおける微小環境の重要性

    松浦 哲也, 加藤 真吾, 落合 雅子, 今井 俊夫, 中島 淳, 筆宝 義隆

    日本癌学会総会記事   76回   P - 2280   2017.9

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  • 術後再建腸管の狭窄に対するシングルバルーン内視鏡による金属ステントの有用性

    岩崎 暁人, 栗田 裕介, 長谷川 翔, 佐藤 高光, 藤田 祐司, 細野 邦広, 加藤 真吾, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   58 ( Suppl.2 )   1940 - 1940   2016.10

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  • 良性胆道狭窄・術前胆道ドレナージに対する超音波内視鏡下胆道ドレナージ術の適応

    佐藤 高光, 栗田 裕介, 長谷川 翔, 岩崎 暁人, 藤田 裕司, 加藤 真吾, 細野 邦広, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   58 ( Suppl.2 )   1939 - 1939   2016.10

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  • 【Interventional EUSのすべて】EUSガイド下腹腔神経叢・神経節ブロック術 EUS-CPN/CGN

    窪田 賢輔, 栗田 裕介, 岩崎 暁人, 佐藤 高光, 加藤 真吾, 香川 幸一, 細野 邦広, 渡辺 誠太郎, 関野 雄典, 藤田 祐司, 石井 研, 長谷川 翔

    消化器内視鏡   28 ( 10 )   1685 - 1690   2016.10

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  • 胆道疾患に対する超音波内視鏡下胆道ドレナージ術の検討

    佐藤 高光, 栗田 裕介, 岩崎 暁人, 加藤 真吾, 香川 幸二, 細野 邦広, 中島 淳, 窪田 賢輔

    胆道   30 ( 3 )   514 - 514   2016.8

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  • 臨床経過からみた内視鏡的胃十二指腸ステント留置術の位置づけ

    佐藤 高光, 栗田 裕介, 長谷川 翔, 岩崎 暁人, 藤田 祐司, 加藤 真吾, 細野 邦広, 小林 規俊, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   58 ( Suppl.1 )   682 - 682   2016.4

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  • 低用量NSAID静注は高リスク群においてPEP発症率を軽減できる

    藤田 祐司, 長谷川 翔, 岩崎 暁人, 佐藤 高光, 加藤 真吾, 細野 邦広, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   58 ( Suppl.1 )   716 - 716   2016.4

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  • 【AIPの概念・診断・治療】 自己免疫性膵胆道疾患における治療法別の長期予後

    窪田 賢輔, 加藤 由理, 石井 研, 佐藤 高光, 加藤 真吾, 藤田 祐司, 渡辺 誠太郎, 関野 雄典, 細野 邦広, 谷田 恵美子, 香川 浩司, 藤澤 聡郎, 藤澤 信隆, 松橋 信行, 中島 淳

    消化器内科   59 ( 5 )   488 - 494   2014.11

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  • 【ドレナージ大全】 胆道ドレナージ術 悪性中下部胆道閉塞 Potential resectable pancreatic head cancer(PRPHC)に対する術前内視鏡的治療戦略

    窪田 賢輔, 藤田 祐司, 関野 雄典, 細野 邦広, 小林 規俊, 佐藤 高光, 加藤 真吾, 渡辺 誠太郎, 山中 正二, 中島 淳, 遠藤 格

    胆と膵   34 ( 臨増特大 )   809 - 815   2013.10

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  • 嚢腫状に拡張した下部胆管に認められた十二指腸乳頭部癌の1例

    藤田 祐司, 渡邉 誠太郎, 佐藤 高光, 加藤 真吾, 細野 邦広, 小林 規俊, 遠藤 格, 山中 正二, 窪田 賢輔

    胆道   27 ( 2 )   240 - 246   2013.5

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  • Primary leiomyoma of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration

    Takamitsu Sato, Shingo Kato, Seitaro Watanabe, Kunihiro Hosono, Noritoshi Kobayashi, Atsushi Nakajima, Kensuke Kubota

    Digestive Endoscopy   24 ( 5 )   380 - 380   2012.9

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  • 膵癌の治療前診断におけるEUS-FNAの有用性

    佐藤 高光, 加藤 真吾, 渡邉 誠太郎, 細野 邦広, 小林 規俊, 前田 愼, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   54 ( Suppl.2 )   2811 - 2811   2012.9

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  • 患者と施行医にやさしい、磁石カテーテルによるENBDチューブの早い、安全、確実な鼻腔内誘導法

    渡邉 誠太郎, 佐藤 高光, 藤井 徹朗, 加藤 真吾, 細野 邦広, 小林 規俊, 前田 愼, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   54 ( Suppl.2 )   2781 - 2781   2012.9

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  • MDCTと腫瘍マーカーを使用した新しい膵癌の動脈浸潤スコアの提案

    渡邉 誠太郎, 小林 規俊, 佐藤 高光, 藤井 徹朗, 加藤 真吾, 細野 邦広, 嶌村 健, 前田 愼, 中島 淳, 遠藤 格, 窪田 賢輔

    膵臓   27 ( 3 )   398 - 398   2012.5

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  • Relationship Between the Plasma Concentrations of Free Choline and Parameters of Adiposity and Histological Findings in Patients With Nonalcoholic Fatty Liver Disease. a Multicenter Study in Japan Reviewed

    Imajo Kento, Yoneda Masato, Fujita Koji, Nozaki Yuichi, Ogawa Yuji, Shinohara Yoshiyasu, Kato Shingo, Mawatari Hironori, Shibata Wataru, Kirikoshi Hiroyuki, Wada Koichiro, Saito Satoru, Nakajima Atsushi

    GASTROENTEROLOGY   142 ( 5 )   S1016   2012.5

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  • Soluble CD14 are a Useful Hallmark of Liver Inflammation and Predictor for Progression of Fibrosis in NASH Reviewed

    Ogawa Yuji, Imajo Kento, Yoneda Masato, Shinohara Yoshiyasu, Kato Shingo, Mawatari Hironori, Nozaki Yuichi, Fujita Koji, Shibata Wataru, Kirikoshi Hiroyuki, Wada Koichiro, Nakajima Atsushi

    GASTROENTEROLOGY   142 ( 5 )   S1019   2012.5

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  • EUS-FNAが診断に有用であった膵腺房細胞癌の1例

    佐藤 高光, 加藤 真吾, 渡邉 誠太郎, 細野 邦広, 長嶋 洋治, 小林 規俊, 前田 愼, 中島 淳, 窪田 賢輔

    膵臓   27 ( 3 )   514 - 514   2012.5

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  • 薬剤性重症膵炎後の感染性膵壊死に、内視鏡的debridementを施行した6歳小児の一例

    佐藤 高光, 加藤 真吾, 渡辺 誠太郎, 細野 邦弘, 小林 規俊, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   54 ( Suppl.1 )   1347 - 1347   2012.4

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  • 当院における超音波内視鏡ガイド下針生検術による上部消化管粘膜下腫瘍診断の遷移

    佐藤 高光, 加藤 真吾, 渡邉 誠太郎, 細野 邦広, 小林 規俊, 前田 愼, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   54 ( Suppl.1 )   1249 - 1249   2012.4

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  • IPMN診断における、IDUSとPOPSの役割について

    小林 規俊, 窪田 賢輔, 中島 淳, 佐藤 高光, 加藤 真吾, 渡邉 誠太郎, 細野 邦広, 前田 愼

    Gastroenterological Endoscopy   54 ( Suppl.1 )   1267 - 1267   2012.4

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  • 当院における内視鏡的胃十二指腸ステント留置術の現状

    小林 規俊, 佐藤 高光, 加藤 真吾, 渡邉 誠太郎, 細野 邦広, 稲森 正彦, 前田 愼, 中島 淳, 遠藤 格, 窪田 賢輔

    Gastroenterological Endoscopy   54 ( Suppl.1 )   1095 - 1095   2012.4

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  • シタグリプチンによる胃排出能に及ぼす影響に関する検討

    野中 敬, 藤井 徹朗, 加藤 真吾, 山田 英司, 酒井 英嗣, 大久保 秀則, 日暮 琢磨, 関野 雄典, 渡邉 誠太郎, 飯田 洋, 細野 邦広, 遠藤 宏樹, 米田 正人, 古出 智子, 高橋 宏和, 阿部 泰伸, 後藤 英司, 前田 愼, 中島 淳, 稲森 正彦

    日本消化器病学会雑誌   109 ( 臨増総会 )   A280 - A280   2012.3

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  • 消化器癌の免疫学的解析と治療 膵癌腫瘍微小環境におけるSemaphorin4Dシグナルの解析

    加藤 真吾, 窪田 賢輔, 中島 淳

    日本消化器病学会雑誌   109 ( 臨増総会 )   A174 - A174   2012.3

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  • von Hippel-Lindau病における膵病変に関する検討

    小林 規俊, 佐藤 高光, 加藤 真吾, 渡邉 誠太郎, 細野 邦広, 嶌村 健, 前田 愼, 中島 淳, 窪田 賢輔

    日本消化器病学会雑誌   109 ( 臨増総会 )   A297 - A297   2012.3

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  • 瘻孔閉鎖を目的とした胃瘻カテーテル抜去の現状と閉鎖不全への対策

    古出 智子, 佐藤 孝光, 山田 英司, 加藤 真吾, 酒井 英嗣, 大久保 秀則, 日暮 琢磨, 後藤 歩, 日下部 明彦, 関野 雄典, 飯田 洋, 野中 敬, 細野 邦広, 遠藤 宏樹, 高橋 宏和, 阿部 泰伸, 後藤 英司, 前田 愼, 中島 淳, 稲森 正彦

    日本消化器病学会雑誌   109 ( 臨増総会 )   A251 - A251   2012.3

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  • 当院における分枝型IPMNの切除例および経過観察例の検討

    小林 規俊, 中島 淳, 窪田 賢輔, 佐藤 高光, 加藤 真吾, 渡邉 誠太郎, 細野 邦広, 前田 愼

    日本消化器病学会雑誌   109 ( 臨増総会 )   A296 - A296   2012.3

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  • 本邦における慢性偽性腸閉塞の疫学調査『慢性特発性偽性腸閉塞症(CIIP)の我が国における疫学・診断・治療の実態調査(厚生労働省難治性疾患克服研究事業)』研究班報告

    飯田 洋, 稲森 正彦, 藤井 徹朗, 加藤 真吾, 山田 英司, 関野 雄典, 酒井 英嗣, 日暮 琢磨, 大久保 秀則, 遠藤 宏樹, 細野 邦広, 野中 敬, 古出 智子, 高橋 宏和, 後藤 歩, 阿部 泰伸, 後藤 英司, 佐藤 元, 中島 淳

    日本消化器病学会雑誌   109 ( 臨増総会 )   A224 - A224   2012.3

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  • 酸分泌抑制薬による胃機能への影響に関する検討

    野中 敬, 藤井 徹朗, 加藤 真吾, 山田 英司, 酒井 英嗣, 大久保 秀則, 日暮 琢磨, 関野 雄典, 渡邉 誠太郎, 飯田 洋, 細野 邦広, 遠藤 宏樹, 米田 正人, 古出 智子, 高橋 宏和, 阿部 泰伸, 前田 愼, 中島 淳, 後藤 英司, 稲森 正彦

    神奈川医学会雑誌   39 ( 1 )   79 - 79   2012.1

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  • 胆管ステント閉塞を契機に発症した、胆石イレウスの一例

    尾崎 優美, 小林 規俊, 佐藤 高光, 渡邊 誠太郎, 細野 邦広, 加藤 真吾, 前田 愼, 中島 淳, 遠藤 格, 窪田 賢輔

    Progress of Digestive Endoscopy   80 ( 1 )   106 - 106   2011.12

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  • Effective treatment for duodenal variceal bleeding using endoscopic ligation Reviewed

    Yutaka Kawakami, Hirokazu Takahashi, Shingo Kato, Takashi Uchiyama, Hironori Mawatari, Hiroshi Iida, Masahiko Inamori, Yasunobu Abe, Atsushi Nakajima

    Hepato-Gastroenterology   58 ( 112 )   2024 - 2025   2011.11

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    Duodenal variceal rupture is rare, and there is little agreement on the best therapeutic option. A 72-year-old man treated for liver cirrhosis with HCV visited the emergency room complaining of dizziness and tarry stool. Fiberscope images showed varices (F2CbRC+) with white plaques at the horizontal region of the duodenum. The patient was treated using endoscopic variceal ligation (EVL), and no more bleeding has been detected. © H.G.E. Update Medical Publishing S.A.

    DOI： 10.5754/hge09470

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  • TACE不応の進行肝細胞がんに対して、5-FU使用の肝動注化学療法は有効か?

    桐越 博之, 米田 正人, 馬渡 弘典, 藤田 浩司, 今城 健人, 加藤 真吾, 鈴木 香峰理, 前田 愼, 中島 淳, 斉藤 聡

    日本消化器病学会雑誌   108 ( 臨増大会 )   A944 - A944   2011.9

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  • HCVにおけるp62の蓄積について(Hepatitis C Virus induces aggregation of p62)

    篠原 義康, 加藤 真吾, 池田 正徳, 加藤 宣之, 前田 愼, 中島 淳, 斉藤 聡

    日本癌学会総会記事   70回   298 - 298   2011.9

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  • 当科における肝門部悪性狭窄に対する、金属ステント両葉ドレナージの成績

    渡邉 誠太郎, 加藤 真吾, 細野 邦広, 嶌村 健, 小林 規俊, 前田 慎, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   53 ( Suppl.2 )   2729 - 2729   2011.9

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  • 当院における粘液産生胆道腫瘍9例の検討

    渡邉 誠太郎, 加藤 真吾, 細野 邦広, 嶌村 健, 小林 規俊, 前田 慎, 中島 淳, 遠藤 格, 稲山 嘉三, 窪田 賢輔

    胆道   25 ( 3 )   458 - 458   2011.8

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  • Rectal carcinoma with metachronous metastasis to the extrahepatic bile duct without liver tumor Reviewed

    Noritoshi Kobayashi, Ryu Kobayashi, Shingo Kato, Seitaro Watanabe, Takashi Uchiyama, Takeshi Shimamura, Kensuke Kubota, Shin Maeda, Atsushi Nakajima, Yasushi Ichikawa, Hisashi Oshiro, Itaru Endo

    Clinical Journal of Gastroenterology   4 ( 4 )   278 - 282   2011.8

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    In July 2003, a 63-year-old man received a low anterior resection for rectal cancer. In February 2006, he underwent a right hepatectomy for a solitary metastatic liver tumor
    the liver tumor had not invaded the bile duct, and a curative resection was performed. In August 2008, an enhanced computed tomography examination revealed a massive focal lesion at the point of the common bile duct. Endoscopic ultrasonography clearly revealed a hyperechoic polypoid lesion that had spread laterally on the surface of the slightly dilated bile duct and had a smooth outer hyperechoic layer. No lymph nodes were present in this region. Endoscopic retrograde cholangiopancreatography revealed an irregular stricture, and a biopsy was performed through the scope. Microscopic examination revealed a tumor characterized as a moderately differentiated adenocarcinoma resembling the liver tumor. We diagnosed the intrabiliary tumor as a metachronous metastatic bile duct tumor from rectal cancer without involvement of the liver parenchyma. This is a very rare case, with recurrence only in an extrahepatic bile duct after the complete resection of a metastatic liver tumor. This is the first clinical, pathological, and radiological description of this rare condition. © Springer 2011.

    DOI： 10.1007/s12328-011-0240-y

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  • choledochoceleに合併した十二指腸乳頭部癌の1例

    藤田 祐司, 渡邉 誠太郎, 佐藤 高光, 加藤 真吾, 細野 邦広, 嶌村 健, 小林 規俊, 前田 慎, 中島 淳, 窪田 賢輔

    胆道   25 ( 3 )   536 - 536   2011.8

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  • 【胆道・膵疾患の画像診断】 膵疾患 自己免疫性膵炎 膵癌との鑑別

    窪田 賢輔, 佐藤 高光, 加藤 真吾, 渡辺 誠太郎, 細野 邦弘, 島村 健, 小林 規俊, 遠藤 格, 中島 淳

    消化器外科   34 ( 8 )   1247 - 1255   2011.7

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  • 胆膵疾患に対する内視鏡的ドレナージ 術後良性胆管狭窄の傾向と内視鏡的治療戦略

    小林 規俊, 加藤 真吾, 渡邊 誠太郎, 細野 邦広, 島村 健, 前田 愼, 中島 淳, 窪田 賢輔

    Progress of Digestive Endoscopy   79 ( 1 )   58 - 58   2011.6

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  • 内視鏡的に摘出したスプーン誤飲の1例

    池川 健, 高橋 宏和, 遠藤 宏樹, 古出 智子, 所 知加子, 稲森 正彦, 阿部 泰伸, 加藤 真吾, 渡邉 誠太郎, 馬渡 弘典, 米田 正人, 後藤 歩, 嶌村 健, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 川名 一朗, 前田 愼, 中島 淳

    Progress of Digestive Endoscopy   79 ( 1 )   103 - 103   2011.6

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  • 進行膵癌による十二指腸狭窄に対して、Niti-Sステント留置が有効であった2例

    桑原 大輔, 小林 規俊, 窪田 賢輔, 島村 健, 渡邊 誠太郎, 加藤 真吾, 馬渡 弘典, 細野 邦広, 遠藤 宏樹, 藤田 浩司, 米田 正人, 高橋 宏和, 古出 智子, 所 知加子, 稲森 正彦, 阿部 泰伸, 桐越 博之, 斎藤 聡, 中島 淳, 前田 愼

    Progress of Digestive Endoscopy   79 ( 1 )   104 - 104   2011.6

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  • 当院における慢性膵炎に対する膵管ステント留置の成績

    渡邉 誠太郎, 加藤 真吾, 細野 邦広, 小林 規俊, 前田 慎, 中島 淳, 窪田 賢輔

    膵臓   26 ( 3 )   454 - 454   2011.6

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  • 【経過を追えた小膵癌 この所見に気をつけろ!】 【症例呈示】 IgG4関連硬化性胆管炎(IgG4-SC)における膵癌併発例の検討

    窪田 賢輔, 渡辺 誠太郎, 細野 邦弘, 加藤 真吾, 島村 健, 小林 規俊, 中島 淳

    肝胆膵画像   13 ( 3 )   299 - 306   2011.5

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    DOI： 10.11477/mf.1428100397

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  • 脾嚢胞破裂 緊急TAE前後の評価にソナゾイド造影超音波(CEUS)が有用であった一例

    鈴木 香峰理, 桐越 博之, 藤田 浩司, 高橋 宏和, 米田 正人, 加藤 真吾, 馬渡 弘典, 中島 淳, 前田 愼, 斉藤 聡

    超音波医学   38 ( 3 )   324 - 324   2011.5

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  • C型慢性肝炎における肝線維化とCETP活性の関係

    馬渡 弘典, 米田 正人, 藤田 浩司, 加藤 真吾, 篠原 義康, 今城 健人, 鈴木 香峰理, 桐越 博之, 前田 愼, 中島 淳, 斉藤 聡

    肝臓   52 ( Suppl.1 )   A203 - A203   2011.4

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  • 当科における非B非C型肝細胞癌の臨床的特徴・内科的治療成績とHBc抗体の意義

    桐越 博之, 米田 正人, 馬渡 弘典, 藤田 浩司, 加藤 真吾, 今城 健人, 鈴木 香峰理, 前田 愼, 中島 淳, 斉藤 聡

    肝臓   52 ( Suppl.1 )   A339 - A339   2011.4

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  • 非切除膵癌に対する内視鏡的金属ステントの早期閉塞に関わる因子の検討

    渡邉 誠太郎, 加藤 真吾, 嶌村 健, 小林 規俊, 前田 愼, 中島 淳, 窪田 賢輔

    Gastroenterological Endoscopy   53 ( Suppl.1 )   822 - 822   2011.3

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  • EUSによる分枝型IPMNの良悪性の鑑別について

    小林 規俊, 窪田 賢輔, 島村 健, 渡邊 誠太郎, 加藤 真吾, 坂本 康成, 遠藤 宏樹, 藤田 浩司, 古出 智子, 米田 正人, 高橋 宏和, 所 知加子, 阿部 泰伸, 稲森 正彦, 桐越 博之, 斎藤 聡, 川名 一朗, 中島 淳, 前田 愼, 遠藤 格

    日本消化器病学会雑誌   108 ( 臨増総会 )   A300 - A300   2011.3

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  • 膵・胆道がんを克服する新たな道はあるか? 基礎と臨床の双方から具体的解決方法の模索を 膵癌における腫瘍間質治療標的としてのSemaphorin 4D signal pathwayの検討

    加藤 真吾, 窪田 賢輔, 中島 淳

    日本消化器病学会雑誌   108 ( 臨増総会 )   A116 - A116   2011.3

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  • 膵尾部癌に対する経胃的EUS-FNA後に播種が疑われた一例

    渡邉 誠太郎, 窪田 賢輔, 加藤 真吾, 嶌村 健, 小林 規俊, 谷口 浩一, 遠藤 格, 前田 愼, 中島 淳

    日本消化器病学会雑誌   108 ( 臨増総会 )   A183 - A183   2011.3

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  • 胃ろうカテーテル抜去後のろう孔閉鎖不全に対し、内視鏡的アルゴンプラズマ凝固とクリップによる縫縮が有効であった2例

    古出 智子, 稲森 正彦, 加藤 真吾, 内山 崇, 関野 雄典, 酒井 英嗣, 今城 健人, 鈴木 香峰理, 飯田 洋, 渡辺 誠太郎, 遠藤 宏樹, 細野 邦広, 坂本 康成, 高橋 宏和, 所 知加子, 後藤 歩, 阿部 泰伸, 中島 淳, 前田 愼, 日下部 明彦

    日本消化器病学会雑誌   108 ( 臨増総会 )   A358 - A358   2011.3

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  • Liver abscess caused by periodontal bacterial infection with Fusobacterium necrophorum Reviewed

    Masato Yoneda, Shingo Kato, Hironori Mawatari, Hiroyuki Kirikoshi, Kento Imajo, Koji Fujita, Hiroki Endo, Hirokazu Takahashi, Masahiko Inamori, Noritoshi Kobayashi, Kensuke Kubota, Satoru Saito, Iwai Tohnai, Kei Watanuki, Koichiro Wada, Shin Maeda, Atsushi Nakajima

    Hepatology Research   41 ( 2 )   194 - 196   2011.2

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    Liver abscess is recognized as a life-threatening disease. However, even in recent years, approximately 50% of liver abscess cases are considered to be cryptogenic. Here, we report a case of liver abscess associated with periodontal bacterial infection by Fusobacterium necrophorum, which is commonly found in the oropharyngeal flora. A 36-year-old man presented with fever and contrast-enhanced abdominal computed tomography revealed multiple liver abscesses. F.necrophorum was isolated from oral smears, liver aspirates and blood samples. Liver abscesses caused by periodontal bacterial infection are rare, however, the incidence is expected to increase in the future, as periodontitis is extremely common and is on the rise as one of the most common chronic infections in the world. A systemic survey including periodontitis may be required for the exact diagnosis of the source of infection. © 2011 The Japan Society of Hepatology.

    DOI： 10.1111/j.1872-034X.2010.00748.x

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  • 経鼻内視鏡 スクリーニング検査での有用性及び応用法の現状(ESD、イレウス管挿入、PEG、ERCPなど) 経鼻内視鏡を用いた内視鏡的胃瘻造設術は合併症を軽減させたか?

    古出 智子, 稲森 正彦, 加藤 真吾, 酒井 英嗣, 関野 雄典, 内山 崇, 渡辺 誠太郎, 飯田 洋, 細野 邦弘, 遠藤 宏樹, 坂本 康成, 高橋 宏和, 所 知加子, 後藤 歩, 阿部 泰伸, 小林 規俊, 窪田 賢輔, 中島 淳, 前田 愼, 日下部 明彦

    Progress of Digestive Endoscopy   78 ( 1 )   62 - 62   2010.12

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  • 当院におけるInterventional EUSの評価

    渡邉 誠太郎, 窪田 賢輔, 加藤 真吾, 嶌村 健, 小林 規俊, 中島 淳

    Gastroenterological Endoscopy   52 ( Suppl.2 )   2552 - 2552   2010.9

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  • 低分化腺癌と浸潤性微小乳頭癌成分を有した巨大胆管のう胞腺癌の1例

    本多 靖, 米田 正人, 藤田 浩司, 加藤 真吾, 馬渡 弘典, 内山 崇, 今城 健人, 留野 渉, 小林 規俊, 窪田 賢輔, 桐越 博之, 高橋 宏和, 稲森 正彦, 細野 邦弘, 遠藤 宏樹, 大城 久, 山中 正二, 稲山 嘉明, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   107 ( 臨増大会 )   A892 - A892   2010.9

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  • 膵癌においてSemaphorin 4Dは腫瘍間質に発現し運動能を制御する

    加藤 真吾, 島村 健, 渡邉 誠太郎, 小林 規俊, 中島 淳, 窪田 賢輔

    日本消化器病学会雑誌   107 ( 臨増大会 )   A944 - A944   2010.9

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  • 高齢者のC型慢性肝炎(1型・高ウイルス量)に対するPeg-IFN+RBV療法のSVR予測における肝生検とASTの有用性

    馬渡 弘典, 米田 正人, 藤田 浩司, 野崎 雄一, 加藤 真吾, 高橋 宏和, 阿部 泰伸, 稲森 正彦, 島村 健, 小林 規俊, 窪田 賢輔, 桐越 博之, 中島 淳, 斉藤 聡

    肝臓   51 ( Suppl.2 )   A594 - A594   2010.9

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  • Acoustic Radiation Force Impulse imaging(ARFI)とフィブロスキャンを用いたNAFLD患者での肝脂肪化、炎症、線維化の比較検討

    米田 正人, 今城 健人, 鈴木 香峰理, 野崎 雄一, 藤田 浩司, 細野 邦広, 遠藤 宏樹, 前田 慎, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 高橋 宏和, 阿部 泰伸, 稲森 正彦, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   107 ( 臨増大会 )   A911 - A911   2010.9

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  • EUS-FNA後腫瘍の急速な増大を認めた悪性リンパ腫の一例

    宮腰 藍衣, 渡邉 誠太郎, 加藤 真吾, 嶌村 健, 小林 規俊, 中島 淳, 窪田 賢輔

    日本消化器病学会雑誌   107 ( 臨増大会 )   A928 - A928   2010.9

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  • 慢性偽性腸閉塞症 内科的診断・治療の現状

    坂本 康成, 稲森 正彦, 加藤 真吾, 内山 崇, 飯田 洋, 関野 雄典, 酒井 英嗣, 細野 邦広, 遠藤 宏樹, 藤田 浩司, 米田 正人, 高橋 宏和, 古出 智子, 所 知加子, 後藤 歩, 阿部 泰伸, 小林 規俊, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   107 ( 臨増大会 )   A823 - A823   2010.9

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  • NASHにおける繊維化発症のメカニズムについて IL-13/TGF-βの役割

    島村 健, 藤澤 俊夫, 加藤 真吾, 渡辺 誠太郎, 藤田 浩司, 米田 正人, 高橋 宏和, 安崎 弘晃, 後藤 歩, 稲森 正彦, 阿部 泰伸, 桐越 博之, 小林 規俊, 川名 一郎, 窪田 賢輔, 斎藤 聡, 市川 靖史, 前田 愼, 中島 淳, Puri R

    日本消化器病学会雑誌   107 ( 臨増大会 )   A909 - A909   2010.9

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  • EUSによるearly-and advanced-stageの自己免疫性膵炎診断の提言

    窪田 賢輔, 加藤 真吾, 秋山 智之, 藤田 浩司, 米田 正人, 高橋 宏和, 稲森 正彦, 阿部 泰伸, 桐越 博之, 小林 規俊, 斉藤 聡, 久富 勘太郎, 松橋 信行, 中島 淳

    Gastroenterological Endoscopy   52 ( 9 )   2745 - 2754   2010.9

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  • PPIとH2RAの単回経口投与における胃内pHの立ち上がりに関する検討

    飯田 洋, 稲森 正彦, 加藤 真吾, 内山 崇, 馬渡 弘典, 細野 邦広, 遠藤 宏樹, 坂本 康成, 藤田 浩司, 古出 智子, 高橋 宏和, 米田 正人, 所 知加子, 後藤 歩, 阿部 泰伸, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   107 ( 臨増大会 )   A805 - A805   2010.9

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  • 急性腹症で発症した異物性胃潰瘍の1例

    梅沢 翔太郎, 高橋 宏和, 内山 崇, 飯田 洋, 坂本 康成, 細野 邦広, 遠藤 宏樹, 古出 智子, 所 知加子, 阿部 泰伸, 稲森 正彦, 加藤 真吾, 渡辺 誠太郎, 藤田 浩司, 米田 正人, 桐越 博之, 小林 規俊, 窪田 賢輔, 斉藤 聡, 中島 淳

    Gastroenterological Endoscopy   52 ( Suppl.2 )   2415 - 2415   2010.9

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  • 非切除膵癌に対する内視鏡的金属ステントの早期閉塞に関わる因子の検討

    渡邉 誠太郎, 加藤 真吾, 嶌村 健, 小林 規俊, 中島 淳, 窪田 賢輔

    胆道   24 ( 3 )   440 - 440   2010.8

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  • 膵癌において、Semaphorin 4Dは腫瘍間質-腫瘍細胞シグナル伝達を介して細胞運動を制御する(Semaphorin 4D controls cell motility by tumor-stroma interaction in pancreatic cancer)

    加藤 真吾, 小林 規俊, 前田 愼, 中島 淳

    日本癌学会総会記事   69回   497 - 497   2010.8

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  • 【膵基礎研究の新しい潮流 Bench to Bedをめざして】 自己免疫性膵炎と膵癌との鑑別診断における十二指腸乳頭部のFOXP3発現の有用性

    窪田 賢輔, 加藤 真吾, 渡辺 誠太郎, 島村 健, 小林 規俊, 久富 勘太郎, 松橋 信行, 中島 淳

    胆と膵   31 ( 6 )   597 - 603   2010.6

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  • HDL-free cholesterolとC型慢性肝炎(genotype1・高ウイルス量)に対する治療抵抗性との関係

    馬渡 弘典, 斉藤 聡, 篠原 義康, 米田 正人, 藤田 浩司, 野崎 雄一, 桐越 博之, 加藤 真吾, 遠藤 宏樹, 細野 邦広, 坂本 康成, 高橋 宏和, 阿部 泰伸, 稲森 正彦, 小林 規俊, 窪田 賢輔, 中島 淳

    肝臓   51 ( Suppl.1 )   A298 - A298   2010.4

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  • 当科における内視鏡的十二指腸乳頭部腫瘍切除術の検討

    渡邉 誠太郎, 窪田 賢輔, 加藤 真吾, 小林 規俊, 中島 淳

    Gastroenterological Endoscopy   52 ( Suppl.1 )   1014 - 1014   2010.4

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  • 分枝型IPMN診断におけるEUSの役割について

    小林 規俊, 窪田 賢輔, 島村 健, 渡邊 誠太郎, 加藤 真吾, 鈴木 香峰里, 内山 崇, 飯田 洋, 馬渡 弘典, 坂本 康成, 細野 邦広, 遠藤 宏樹, 野崎 雄一, 藤田 浩司, 高橋 宏和, 米田 正人, 阿部 泰伸, 稲森 正彦, 桐越 博之, 斉藤 聡, 中島 淳

    Gastroenterological Endoscopy   52 ( Suppl.1 )   1075 - 1075   2010.4

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  • 内視鏡的治療からみた悪性胆管狭窄と良性胆管狭窄の違い 肝移植後胆管狭窄症例を中心に

    小林 規俊, 窪田 賢輔, 島村 健, 渡邊 誠太郎, 加藤 真吾, 内山 崇, 鈴木 香峰理, 飯田 洋, 馬渡 弘典, 細野 邦広, 坂本 康成, 遠藤 宏樹, 野崎 雄一, 藤田 浩司, 米田 正人, 稲森 正彦, 桐越 博之, 斉藤 聡, 武田 和永, 遠藤 格, 中島 淳

    Gastroenterological Endoscopy   52 ( Suppl.1 )   971 - 971   2010.4

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  • 特異な画像を呈し、診断が困難であった肝内胆管癌の一例

    加藤 真吾, 窪田 賢輔, 小林 規俊, 渡邉 誠太郎, 中島 淳

    Gastroenterological Endoscopy   52 ( Suppl.1 )   971 - 971   2010.4

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  • 大腸憩室症の存在部位と内臓脂肪との関連性についての検討

    渡邉 誠太郎, 稲森 正彦, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 鈴木 香峰理, 細野 邦広, 遠藤 宏樹, 坂本 康成, 古出 智子, 高橋 宏和, 所 知加子, 阿部 泰伸, 桐越 博之, 小林 規俊, 嶌村 健, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   107 ( 臨増総会 )   A208 - A208   2010.3

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  • 内視鏡的胃ろう造設術後の出血に関する検討

    古出 智子, 稲森 正彦, 日下部 明彦, 加藤 真吾, 内山 崇, 飯田 洋, 細野 邦広, 遠藤 宏樹, 坂本 康成, 藤田 浩司, 高橋 宏和, 米田 正人, 所 知加子, 後藤 歩, 阿部 泰伸, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   107 ( 臨増総会 )   A250 - A250   2010.3

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  • 肝腫瘍、膵腫瘍の予後因子としてのFOXP3+制御性T細胞について

    小林 規俊, 平岡 伸介, 窪田 賢輔, 渡邊 誠太郎, 加藤 真吾, 島村 健, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦広, 遠藤 宏樹, 野崎 雄一, 藤田 浩司, 高橋 宏和, 米田 正人, 阿部 泰伸, 稲森 正彦, 桐越 博之, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   107 ( 臨増総会 )   A233 - A233   2010.3

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  • 当院における分枝型IPMNの切除例および経過観察例の検討

    小林 規俊, 窪田 賢輔, 渡邊 誠太郎, 加藤 真吾, 島村 健, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦広, 遠藤 宏樹, 野崎 雄一, 藤田 浩司, 高橋 宏和, 米田 正人, 阿部 泰伸, 稲森 正彦, 桐越 博之, 斉藤 聡, 遠藤 格, 中島 淳

    日本消化器病学会雑誌   107 ( 臨増総会 )   A234 - A234   2010.3

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  • NASH患者に対するエゼチミブの有用性 6ヵ月投与による肝組織改善効果のパイロットスタディー

    米田 正人, 藤田 浩司, 野崎 雄一, 遠藤 宏樹, 加藤 真吾, 細野 邦広, 高橋 宏和, 鈴木 香峰理, 内山 崇, 坂本 康成, 飯田 洋, 馬渡 弘典, 小林 規俊, 島村 健, 阿部 泰伸, 稲森 正彦, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   107 ( 臨増総会 )   A227 - A227   2010.3

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  • 膵癌におけるSema4D-PlexinB1 signal pathwayの機能解析

    加藤 真吾, 窪田 賢輔, 小林 規俊, 島村 健, 渡邉 誠太郎, 馬渡 弘典, 野崎 雄一, 藤田 浩司, 米田 正人, 桐越 博之, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   107 ( 臨増総会 )   A232 - A232   2010.3

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  • A mucosa-associated lymphoid tissue (MALT) lymphoma of the small intestine that was difficult to diagnose endoscopically Reviewed

    K. Yoneda, H. Takahashi, Y. Abe, M. Inamori, S. Kato, T. Uchiyama, H. Iida, H. Mawatari, K. Hosono, H. Endo, Y. Nozaki, T. Akiyama, K. Fujita, M. Yoneda, N. Kobayashi, H. Kirikoshi, K. Kubota, S. Saito, A. Nakajima

    Endoscopy   42 ( 2 )   E175   2010

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  • Duodenal Gastrointestinal stromal tumor resembling a pancreatic neuroendocrine tumor in a patient with neurofibromatosis type I (von Recklinghausen's disease): A case report Reviewed

    Shinji Ohtake, Noritoshi Kobayashi, Shingo Kato, Kensuke Kubota, Itaru Endo, Yoshiaki Inayama, Atsushi Nakajima

    Journal of Medical Case Reports   4 ( 1 )   302   2010

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    Introduction: Gastrointestinal stromal tumor is the most frequent nonepithelial tumor found in the gastrointestinal tract. One important clinical problem is that gastrointestinal stromal tumors, especially the extramural growth type, can be difficult to distinguish from other organ tumors. The case of a patient with an extramural gastrointestinal stromal tumor of the duodenum that mimicked a pancreatic head tumor has previously been reported. Here, we report a rare case of a patient with a duodenal gastrointestinal stromal tumor with extramural growth that mimicked a pancreatic neuroendocrine tumor. In this case, the gastrointestinal stromal tumor was also associated with neurofibromatosis type 1 (also known as von Recklinghausen's disease). To the best of our knowledge, this is the first report to describe the case of a patient with a duodenal gastrointestinal stromal tumor with neurofibromatosis type 1 in which the radiological findings resembled those of a pancreatic neuroendocrine tumor. Case presentation: A 60-year-old Japanese woman with a history of neurofibromatosis type 1 was admitted to our hospital for the treatment of a tumor of her pancreas. She had no symptoms, but an abdominal ultrasonography screening examination had revealed a hypoechoic mass in the head of her pancreas. Laboratory data, including tumor markers, were within the normal ranges, and her insulin and glucagon levels were also within the normal ranges. However, her plasma gastrin level was elevated at 580 pg/mL (30 to 150 pg/mL). A computed tomography examination revealed a hypervascular tumor measuring 14 mm in diameter in the head of her pancreas. We diagnosed the patient as having a pancreatic neuroendocrine tumor and performed a tumor resection with a duodenal wedge resection. Microscopic analysis revealed spindle cell tumors in a trabecular pattern. The patient was finally diagnosed as having a duodenal gastrointestinal stromal tumor of the uncommitted type. Conclusion: Extramural growth-type gastrointestinal stromal tumors can be difficult to distinguish from other organ tumors. In our case, a duodenal gastrointestinal stromal tumor was difficult to distinguish from a pancreatic neuroendocrine tumor based on radiological findings. When patients are identified as having hypervascular lesions that have adhered to the gastrointestinal tract, the possibility of an extramural growth-type gastrointestinal stromal tumor as a differential diagnosis should be considered in patients with neurofibromatosis type 1.

    DOI： 10.1186/1752-1947-4-302

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  • Metastatic tumor in the colon from renal cell carcinoma Reviewed

    Yuichi Nozaki, Masahiko Inamori, Koji Fujita, Masato Yoneda, Shingo Kato, Takashi Uchiyama, Kaori Suzuki, Seitaro Watanabe, Hironori Mawatari, Hiroshi Iida, Kunihiro Hosono, Hiroki Endo, Yasunari Sakamoto, Kyoko Yoneda, Hirokazu Takahashi, Tomoko Koide, Chikako Tokoro, Noritoshi Kobayashi, Hiroyuki Kirikoshi, Takeshi Shimamura, Yasunobu Abe, Kensuke Kubota, Satoru Saito, Hisashi Oshiro, Yoshiaki Inayama, Atsushi Nakajima

    Internal Medicine   49 ( 7 )   709   2010

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    DOI： 10.2169/internalmedicine.49.3233

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  • Esophagomediastinal and esophagobronchial fistulas associated with invasive aspergillosis Reviewed

    S. Kato, S. Inoue, M. Inamori, N. Miyazawa, T. Sato, N. Kobayashi, K. Mishina, M. Sasaki, Y. Ishigatsubo, A. Nakajima

    Endoscopy   42 ( 2 )   E48 - E49   2010

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  • A duodenal mucosal lesion coming from pancreatic arteriovenous malformation Reviewed

    Shingo Kato, Noritoshi Kobayashi, Kensuke Kubota, Hiroyuki Kirikoshi, Seitaro Watanabe, Masami Ogawa, Masahiko Inamori, Takeshi Shimamura, Wataru Tomeno, Atsushi Nakajima, Kazuhisa Takeda, Itaru Endo, Yoji Nagashima, Ichiro Aoki

    Gastrointestinal Endoscopy   71 ( 7 )   1299 - 1300   2010

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    DOI： 10.1016/j.gie.2010.01.033

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  • 消化器内視鏡偶発症に対するトラブルシューティング 胃瘻損傷時の胃壁固定を用いたリカバリー

    古出 智子, 稲森 正彦, 加藤 真吾, 内山 崇, 渡邊 誠太郎, 飯田 洋, 遠藤 宏樹, 細野 邦広, 藤田 浩司, 米田 正人, 高橋 宏和, 所 知加子, 後藤 歩, 阿部 泰伸, 嶌村 健, 小林 規俊, 窪田 賢輔, 佐藤 晶子, 日下部 明彦, 中島 淳

    Progress of Digestive Endoscopy   76 ( 1 )   81 - 81   2009.12

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  • 超音波内視鏡的胆道ドレナージが有用であった膵頭部腫瘍の一例

    藤原 祐, 窪田 賢輔, 加藤 真吾, 小川 真実, 小林 規俊, 中島 淳

    Progress of Digestive Endoscopy   76 ( 1 )   125 - 125   2009.12

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  • 十二指腸静脈瘤に対し内視鏡的静脈瘤結紮術が奏効した1例

    加藤 真吾, 高橋 宏和, 阿部 泰伸, 稲森 正彦, 所 知加子, 古出 智子, 坂本 康成, 飯田 洋, 細野 邦弘, 遠藤 宏樹, 中島 淳

    Progress of Digestive Endoscopy   75 ( 2 )   78,4 - 79,4   2009.12

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    DOI： 10.11641/pde.75.2_78

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    Other Link： http://search.jamas.or.jp/link/ui/2010068090

  • 【自己免疫性膵炎の最前線】 自己免疫性膵炎の診断 膵癌との鑑別を中心に ERCP・IDUS

    窪田 賢輔, 内山 崇, 加藤 真吾, 渡辺 誠太郎, 小川 真実, 小林 規俊, 久富 勘太郎, 松橋 信行, 中島 淳

    肝胆膵画像   11 ( 6 )   639 - 645   2009.11

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    DOI： 10.11477/mf.1428100209

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  • 【自己免疫関連性胆管炎をめぐって】 IgG4関連硬化性胆管炎(SC-AIP)の再燃に関する危険因子の検討

    窪田 賢輔, 内山 崇, 加藤 真吾, 渡辺 誠太郎, 小川 真実, 小林 規俊, 久富 勘太郎, 松橋 信行, 中島 淳, 遠藤 格

    胆と膵   30 ( 10 )   1311 - 1315   2009.10

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  • 6歳小児の感染性膵仮性嚢胞に対し、direct endoscopic drainageを施行した一例

    加藤 真吾, 窪田 賢輔, 小林 規俊, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦広, 野崎 雄一, 遠藤 宏樹, 米田 恭子, 秋山 智之, 藤田 浩司, 高橋 宏和, 米田 正人, 稲森 正彦, 阿部 泰伸, 桐越 博之, 斉藤 聡, 中島 淳

    Gastroenterological Endoscopy   51 ( Suppl.2 )   2300 - 2300   2009.9

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  • H2受容体拮抗薬投与初期における胃内pHに関する検討 mint oilの効果について

    飯田 洋, 稲森 正彦, 加藤 真吾, 内山 崇, 細野 邦広, 遠藤 宏樹, 米田 恭子, 秋山 智之, 藤田 浩司, 坂本 康成, 高橋 宏和, 米田 正人, 後藤 歩, 廣川 智, 阿部 泰伸, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増大会 )   A763 - A763   2009.9

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  • HBs抗体陽性でALTが軽度異常を示したB型肝炎の1例

    馬渡 弘典, 斉藤 聡, 桐越 博之, 米田 正人, 藤田 浩司, 野崎 雄一, 飯田 洋, 篠原 義康, 秋山 智之, 内山 崇, 加藤 真吾, 遠藤 宏樹, 米田 恭子, 細野 邦広, 高橋 宏和, 阿部 泰伸, 稲森 正彦, 小林 規俊, 窪田 賢輔, 中島 淳

    肝臓   50 ( Suppl.2 )   A504 - A504   2009.9

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  • Telmisartan投与が推奨されるNASH背景病態の検討

    藤田 浩司, 野崎 雄一, 留野 渉, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 坂本 康成, 細野 邦広, 遠藤 宏樹, 米田 正人, 高橋 宏和, 稲森 正彦, 阿部 泰伸, 島村 健, 小林 規俊, 桐越 博之, 窪田 賢輔, 斎藤 聡, 中島 淳

    肝臓   50 ( Suppl.2 )   A553 - A553   2009.9

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  • IPMNの多段階発がんにおけるFOXP3+制御性T細胞の変化についての検討

    小林 規俊, 窪田 賢輔, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦広, 遠藤 宏樹, 野崎 雄一, 米田 恭子, 藤田 浩司, 高橋 宏和, 米田 正人, 阿部 泰伸, 稲森 正彦, 桐越 博之, 斉藤 聡, 上田 倫夫, 遠藤 格, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増大会 )   A922 - A922   2009.9

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  • 開腹生検によっても膵癌の確定診断に至らなかった症例の検討

    小林 規俊, 窪田 賢輔, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦広, 遠藤 宏樹, 野崎 雄一, 米田 恭子, 藤田 浩司, 高橋 宏和, 米田 正人, 阿部 泰伸, 稲森 正彦, 桐越 博之, 斉藤 聡, 遠藤 格, 稲山 嘉明, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増大会 )   A931 - A931   2009.9

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  • 大腸ポリープ、大腸癌の診断に血清レプチン値は有用か

    内山 崇, 高橋 宏和, 飯田 洋, 遠藤 宏樹, 細野 邦弘, 秋山 智之, 阿部 泰伸, 稲森 正彦, 加藤 真吾, 渡辺 誠太郎, 馬渡 弘典, 米田 恭子, 野崎 雄一, 藤田 浩司, 米田 正人, 桐越 博之, 小林 規俊, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増大会 )   A853 - A853   2009.9

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  • 当院で経験した無症候性に診断された日本住血吸虫症の3例

    竹前 久美, 米田 正人, 野崎 雄一, 留野 渉, 藤田 浩司, 内山 崇, 遠藤 宏樹, 飯田 洋, 馬渡 弘典, 細野 邦彦, 高橋 宏和, 加藤 真吾, 秋山 智之, 阿部 泰伸, 稲森 正彦, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増大会 )   A094 - A094   2009.9

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  • 十二指腸静脈瘤破裂に対し3度のEVLが必要であった1例

    高橋 宏和, 阿部 泰伸, 稲森 正彦, 留野 渉, 渡辺 誠太郎, 加藤 真吾, 内山 崇, 藤田 浩司, 米田 正人, 島村 健, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 上野 規男, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増大会 )   A793 - A793   2009.9

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  • 生活習慣病からみた大腸癌の新たな化学発癌予防 抗糖尿病薬メトホルミンを用いた検討

    細野 邦広, 高橋 宏和, 加藤 真吾, 内山 嵩, 鈴木 香峰理, 飯田 洋, 馬渡 弘典, 遠藤 宏樹, 野崎 雄一, 坂本 康成, 米田 恭子, 藤田 浩司, 米田 正人, 阿部 泰伸, 稲森 正彦, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増大会 )   A839 - A839   2009.9

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  • 満腹感と膨満感を日本人は区別しているのか?(第2報)

    坂本 康成, 稲森 正彦, 飯田 洋, 加藤 真吾, 内山 崇, 細野 邦広, 遠藤 宏樹, 米田 恭子, 秋山 智之, 藤田 浩司, 高橋 宏和, 米田 正人, 後藤 歩, 廣川 智, 阿部 泰伸, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増大会 )   A779 - A779   2009.9

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  • 急激に進行した食道静脈瘤破裂に対する内視鏡治療後に脳梗塞を起した1例

    竹中 麻起, 内山 崇, 高橋 宏和, 阿部 泰伸, 加藤 真吾, 飯田 洋, 馬渡 弘典, 遠藤 宏樹, 野崎 雄一, 細野 邦広, 秋山 智之, 米田 恭子, 藤田 浩司, 米田 正人, 稲森 正彦, 桐越 博之, 小林 規俊, 窪田 賢輔, 斉藤 聡, 中島 淳

    Gastroenterological Endoscopy   51 ( Suppl.2 )   2208 - 2208   2009.9

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  • metallic stent逸脱に対し、内視鏡的抜去が可能であった膵癌の2例

    加藤 真吾, 窪田 賢輔, 小林 規俊, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦広, 野崎 雄一, 遠藤 宏樹, 米田 恭子, 秋山 智之, 藤田 浩司, 高橋 宏和, 米田 正人, 稲森 正彦, 阿部 泰伸, 桐越 博之, 斉藤 聡, 中島 淳

    Gastroenterological Endoscopy   51 ( Suppl.2 )   2272 - 2272   2009.9

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  • 十二指腸球部に穿破をきたした胆嚢がんの一例

    石戸 岳仁, 小林 規俊, 窪田 賢輔, 加藤 真吾, 山本 晴美, 内山 崇, 飯田 洋, 馬渡 弘典, 米田 恭子, 遠藤 宏樹, 野崎 雄一, 藤田 浩司, 米田 正人, 高橋 宏和, 阿部 泰伸, 稲森 正彦, 桐越 博之, 斉藤 聡, 遠藤 格, 中島 淳

    Gastroenterological Endoscopy   51 ( Suppl.2 )   2294 - 2294   2009.9

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  • 下部胆管にskip lesionを有した早期十二指腸乳頭部癌の一例

    加藤 真吾, 窪田 賢輔, 小川 真実, 稲森 正彦, 遠藤 格, 稲山 嘉明, 中島 淳

    胆道   23 ( 3 )   531 - 531   2009.8

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  • 硬化性胆管炎の病態と胆管がんの発生リスク IDUSによる硬化性胆管炎の鑑別診断

    窪田 賢輔, 加藤 真吾, 中島 淳

    胆道   23 ( 3 )   422 - 422   2009.8

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  • 膵癌細胞株においてSemaphorin 4DはMetの活性化を介して細胞運動を誘導する(Semaphorin 4D induced cell migration through the activation of Met in pancreatic cancer cell line)

    加藤 真吾, 小林 規俊, 中島 淳

    日本癌学会総会記事   68回   45 - 46   2009.8

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  • IPMNにおけるFOXP3陽性制御性T細胞の発がんとその進行に関する検討(FOXP3 Regulatory T cells Increases during Carclnogenesis of Intraductal Papillary Mucinous Neoplasms of the Pancreas)

    小林 規俊, 加藤 真吾, 中島 淳

    日本癌学会総会記事   68回   316 - 316   2009.8

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  • 経鼻内視鏡の現状と問題点 経鼻内視鏡の位置づけ 医療者側の評価

    細野 邦広, 稲森 正彦, 内山 崇, 加藤 真吾, 飯田 洋, 遠藤 宏樹, 秋山 智之, 池田 多聞, 米田 恭子, 坂本 康成, 藤田 浩司, 米田 正人, 高橋 宏和, 後藤 歩, 阿部 泰伸, 桐越 博之, 小林 規俊, 窪田 賢輔, 斎藤 聡, 中島 淳

    Progress of Digestive Endoscopy   75 ( 1 )   76 - 76   2009.6

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  • 当院におけるEUS下膵仮性嚢胞ドレナージ20例の検討

    加藤 真吾, 窪田 賢輔, 小林 規俊, 中島 淳

    膵臓   24 ( 3 )   450 - 450   2009.6

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  • 十二指腸静脈瘤破裂に対し2度のEVLが奏功した1例

    加藤 真吾, 高橋 宏和, 阿部 泰伸, 稲森 正彦, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦広, 遠藤 宏樹, 野崎 雄一, 秋山 智之, 米田 恭子, 藤田 浩司, 米田 正人, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 上野 規男, 中島 淳

    Progress of Digestive Endoscopy   75 ( 1 )   81 - 81   2009.6

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  • 肝硬変とIL-13

    加藤 真吾, 島村 健, 藤澤 聡郎, 小林 規俊, 窪田 賢輔, 中島 淳

    臨床免疫・アレルギー科   51 ( 6 )   647 - 653   2009.6

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  • Aberrant crypt fociの自然史に対する解析

    高橋 宏和, 細野 邦広, 遠藤 宏樹, 米田 恭子, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 野崎 雄一, 秋山 智之, 藤田 浩司, 米田 正人, 稲森 正彦, 阿部 泰伸, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 上野 規男, 中島 淳

    Gastroenterological Endoscopy   51 ( Suppl.1 )   832 - 832   2009.4

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  • C型慢性肝炎患者におけるインスリン抵抗性の変化

    斉藤 聡, 馬渡 弘典, 桐越 博之, 米田 正人, 藤田 浩司, 野崎 雄一, 飯田 洋, 内山 崇, 加藤 真吾, 篠原 義康, 遠藤 宏樹, 細野 邦広, 阿部 泰伸, 稲森 正彦, 高橋 宏和, 小林 規俊, 窪田 賢輔, 中島 淳

    肝臓   50 ( Suppl.1 )   A380 - A380   2009.4

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  • 糖尿病患者に発症した虚血性胃炎の1症例

    細野 邦広, 稲森 正彦, 加藤 真吾, 遠藤 宏樹, 藤田 浩司, 高橋 宏和, 阿部 泰伸, 中島 淳

    Gastroenterological Endoscopy   51 ( Suppl.1 )   959 - 959   2009.4

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  • 当院におけるB型慢性肝炎と肝癌発癌の検討

    内山 崇, 斉藤 聡, 加藤 真吾, 飯田 洋, 馬渡 弘典, 遠藤 宏樹, 野崎 雄一, 細野 邦広, 秋山 智之, 藤田 浩司, 米田 恭子, 高橋 宏和, 米田 正人, 阿部 泰伸, 稲森 正彦, 桐越 博之, 小林 規俊, 窪田 賢輔, 中島 淳

    肝臓   50 ( Suppl.1 )   A311 - A311   2009.4

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  • 肝移植後胆管狭窄に対する内視鏡的治療に関する検討

    小林 規俊, 窪田 賢輔, 加藤 真吾, 小川 真実, 馬渡 弘典, 飯田 洋, 内山 崇, 米田 恭子, 遠藤 宏樹, 秋山 智之, 藤田 浩司, 高橋 宏和, 米田 正人, 阿部 泰伸, 稲森 正彦, 桐越 博之, 斉藤 聡, 上野 規男, 武田 和永, 遠藤 格, 中島 淳

    Gastroenterological Endoscopy   51 ( Suppl.1 )   845 - 845   2009.4

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  • 膵動静脈奇形の内視鏡所見についての検討

    加藤 真吾, 小林 規俊, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦広, 野崎 雄一, 遠藤 宏樹, 米田 恭子, 秋山 智之, 藤田 浩司, 高橋 宏和, 米田 正人, 稲森 正彦, 阿部 泰伸, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    Gastroenterological Endoscopy   51 ( Suppl.1 )   846 - 846   2009.4

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  • NASH診断、進行度判定における炎症マーカー高感度CRPとPentraxin3の臨床有用性に対する比較検討

    米田 正人, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦広, 野崎 雄一, 遠藤 宏樹, 米田 恭子, 藤田 浩司, 高橋 宏和, 留野 渉, 阿部 泰伸, 稲森 正彦, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 前山 史朗, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A206 - A206   2009.3

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  • Mikulicz病を合併した自己免疫性膵炎症例の臨床病理学的検討

    和田 朋子, 石田 修一, 加藤 真吾, 小林 規俊, 窪田 賢輔, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A492 - A492   2009.3

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  • 大量の胸水を契機に発症し、2度のEUS下ドレナージ術が有効であった慢性膵炎の一例

    大森 尚子, 小林 規俊, 窪田 賢輔, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦広, 遠藤 宏樹, 野崎 雄一, 米田 恭子, 秋山 智之, 藤田 浩司, 高橋 宏和, 米田 正人, 阿部 泰伸, 稲森 正彦, 桐越 博之, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A496 - A496   2009.3

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  • C型慢性肝炎に対しインターフェロン治療中にShewanella putrefasciensによる敗血症を合併し救命しえた先天性胆道閉鎖症術後の1例

    濱口 冴香, 留野 渉, 小川 祐二, 加藤 真吾, 米田 恭子, 遠藤 宏樹, 野崎 雄一, 飯田 洋, 馬渡 弘典, 内山 崇, 藤田 浩司, 米田 正人, 高橋 宏和, 阿部 泰伸, 稲森 正彦, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A413 - A413   2009.3

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  • 下血が発見の契機となった高齢発症gastrointestinal stromal tumor(GIST)の1例

    内山 崇, 高橋 宏和, 加藤 真吾, 飯田 洋, 馬渡 弘典, 遠藤 宏樹, 野崎 雄一, 細野 邦弘, 秋山 智之, 藤田 浩司, 米田 恭子, 米田 正人, 稲森 正彦, 阿部 泰伸, 桐越 博之, 小林 規俊, 窪田 賢輔, 斉藤 聡, 利野 靖, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A457 - A457   2009.3

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  • 小腸癌の診断に冠状断CT像が有用であった1例

    飯田 洋, 稲森 正彦, 加藤 真吾, 内山 崇, 馬渡 弘典, 遠藤 宏樹, 細野 邦広, 秋山 智之, 米田 恭子, 藤田 浩司, 高橋 宏和, 米田 正人, 阿部 泰伸, 桐越 博之, 窪田 賢輔, 斉藤 聡, 菅野 信洋, 利野 靖, 稲山 嘉明, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A398 - A398   2009.3

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  • 健康診断で偶発的に発見された肝血管筋脂肪腫の1例

    小川 祐二, 留野 渉, 谷口 礼央, 加藤 真吾, 内山 崇, 日暮 琢磨, 馬渡 弘典, 飯田 洋, 米田 恭子, 藤田 浩司, 米田 正人, 高橋 宏和, 小林 規俊, 阿部 泰伸, 稲森 正彦, 桐越 博之, 坂口 隆, 窪田 賢輔, 齋藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A370 - A370   2009.3

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  • Barrett粘膜の形状・長さと逆流性食道炎の分布の関連性について

    秋山 智之, 稲森 正彦, 野崎 雄一, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦広, 遠藤 宏樹, 米田 恭子, 米田 正人, 高橋 宏和, 後藤 歩, 藤田 浩司, 阿部 泰伸, 小林 規俊, 桐越 博之, 窪田 賢輔, 斎藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A373 - A373   2009.3

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  • 内臓脂肪およびアディポサイトカインの大腸発癌に関する解析

    高橋 宏和, 細野 邦広, 中島 淳, 米田 恭子, 遠藤 宏樹, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 野崎 雄一, 秋山 智之, 藤田 浩司, 米田 正人, 稲森 正彦, 阿部 泰伸, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 上野 規男

    日本消化器病学会雑誌   106 ( 臨増総会 )   A269 - A269   2009.3

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  • チューインガムはdistention induced accommodationに影響するか? 飲水試験を用いた研究

    坂本 康成, 稲森 正彦, 加藤 真吾, 飯田 洋, 内山 崇, 野崎 雄一, 後藤 歩, 細野 邦広, 遠藤 宏樹, 秋山 智之, 米田 恭子, 藤田 浩司, 米田 正人, 高橋 宏和, 阿部 泰伸, 小林 規俊, 桐越 博之, 窪田 賢輔, 斎藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A336 - A336   2009.3

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  • 膵癌におけるSema4D/PlexinB1/METの発現とその機能解析

    加藤 真吾, 小林 規俊, 内山 崇, 飯田 洋, 馬渡 弘典, 細野 邦弘, 野崎 雄一, 遠藤 宏樹, 米田 恭子, 秋山 智之, 藤田 浩司, 高橋 宏和, 米田 正人, 稲森 正彦, 阿部 泰伸, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A245 - A245   2009.3

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  • IPMNの多段階発がんにおけるFOXP3+制御性T細胞の変化についての検討

    小林 規俊, 窪田 賢輔, 小川 真実, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 遠藤 宏樹, 野崎 雄一, 米田 恭子, 秋山 智之, 藤田 浩司, 高橋 宏和, 米田 正人, 阿部 泰伸, 稲森 正彦, 桐越 博之, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A246 - A246   2009.3

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  • 肝ミクロソームTG輸送蛋白(MTTP)がNAFLD病態進展に与える影響

    藤田 浩司, 野崎 雄一, 加藤 真吾, 内山 崇, 飯田 洋, 馬渡 弘典, 遠藤 宏樹, 細野 邦広, 秋山 智之, 米田 恭子, 池田 多聞, 米田 正人, 高橋 宏和, 阿部 泰伸, 稲森 正彦, 小林 規俊, 桐越 博之, 窪田 賢輔, 斎藤 聡, 中島 淳

    日本消化器病学会雑誌   106 ( 臨増総会 )   A205 - A205   2009.3

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  • 胃瘻カテーテル迷入後の胃壁固定を用いた加療

    稲森 正彦, 内山 崇, 加藤 真吾, 飯田 洋, 馬渡 弘典, 遠藤 宏樹, 細野 邦弘, 秋山 智之, 米田 恭子, 藤田 浩司, 米田 正人, 高橋 宏和, 後藤 歩, 阿部 泰伸, 日下部 明彦, 桐越 博之, 小林 規俊, 窪田 賢輔, 斉藤 聡, 中島 淳

    神奈川医学会雑誌   36 ( 1 )   65 - 66   2009.1

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  • Asymptomatic hepatic Schistosomiasis detected by ultrasonograpy and confirmed by liver biopsy Reviewed

    Yuichi Nozaki, Masahiko Inamori, Koji Fujita, Masato Yoneda, Takashi Uchiyama, Shingo Kato, Hironori Mawatari, Hiroshi Iida, Kunihiro Hosono, Hiroki Endo, Tomoyuki Akiyama, Kyoko Yoneda, Hirokazu Takahashi, Ayumu Goto, Noritoshi Kobayashi, Hiroyuki Kirikoshi, Yasunobu Abe, Kensuke Kubota, Satoru Saito, Hanako Kurai, Shoji Yamanaka, Atsushi Nakajima

    Internal Medicine   48 ( 12 )   1109 - 1110   2009

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  • 治療の効果判定にVater乳頭部生検が有用であった自己免疫性膵炎の一例

    石田 修一, 窪田 賢輔, 小林 規俊, 加藤 真吾, 稲森 正彦, 阿部 泰伸, 斎藤 聡, 稲山 嘉昭, 山中 正二, 中島 淳

    Progress of Digestive Endoscopy   74 ( 1 )   102 - 102   2008.12

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  • THE COMPARISON OF THE TRANS-ARTERIAL CHEMOEMBOLIZATION (TACE) MONOTHERAPY AND THE COMBINED TACE WITH PERCUTANEOUS LOCAL THERAPY FOR HEPATOCELLULAR CARCINOMA (HCC)

    Hiroyuki Kirikoshi, Satoru Saito, Masato Yonedo, Koji Fujita, Hironori Mawatari, Yuichi Nozaki, Takashi Uchiyama, Tamon Ikeda, Kunihiro Hosono, Tomoyuki Akiyama, Hiroki Endo, Kyoko Yoneda, Masahiko Inamori, Hirokazu Takahashi, Hiroshi Iida, Shingo Kato, Yasunobu Abe, Noritoshi Kobayashi, Kensuke Kubota, Atsushi Nakajima

    HEPATOLOGY   48 ( 4 )   967A - 968A   2008.10

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    Web of Science

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  • 当院におけるB型慢性肝炎に対するlamivudine治療の実際

    内山 崇, 斉藤 聡, 加藤 真吾, 飯田 洋, 馬渡 弘典, 遠藤 宏樹, 野崎 雄一, 細野 邦弘, 秋山 智則, 藤田 浩司, 米田 恭子, 高橋 宏和, 米田 正人, 阿部 泰伸, 稲森 正彦, 桐越 博之, 小林 則俊, 窪田 賢輔, 中島 淳

    肝臓   49 ( Suppl.3 )   A752 - A752   2008.10

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  • 門脈血栓による胃静脈瘤破裂に対しヒストアクリル局注法を繰り返し止血を得た1例

    谷口 礼央, 高橋 宏和, 飯田 洋, 阿部 泰伸, 稲森 正彦, 加藤 真吾, 内山 崇, 馬渡 弘典, 藤田 浩司, 米田 正人, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    Gastroenterological Endoscopy   50 ( Suppl.2 )   2322 - 2322   2008.9

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  • 血友病Aに発症した門脈血栓症に対しAT3およびダナパロイドナトリウム併用療法が有効であった1例

    留野 渉, 高橋 宏和, 飯田 洋, 阿部 泰伸, 稲森 正彦, 加藤 真吾, 内山 崇, 馬渡 弘典, 藤田 浩司, 米田 正人, 小林 規俊, 桐越 博之, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   105 ( 臨増大会 )   A873 - A873   2008.9

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  • EzetimibeによるNAFLD病態の改善効果に関する検討

    野崎 雄一, 藤田 浩司, 米田 正人, 留野 渉, 加藤 真吾, 馬渡 弘典, 飯田 洋, 遠藤 宏樹, 秋山 智之, 米田 恭子, 高橋 宏和, 後藤 歩, 廣川 智, 阿部 泰伸, 稲森 正彦, 桐越 博之, 小林 規俊, 窪田 賢輔, 斉藤 聡, 中島 淳

    日本消化器病学会雑誌   105 ( 臨増大会 )   A849 - A849   2008.9

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  • NASH診断、線維化進行判定におけるPentraxin3の有効性についての検討

    加藤 真吾, 米田 正人, 内山 崇, 留野 渉, 馬渡 弘典, 飯田 洋, 野崎 雄一, 遠藤 宏樹, 米田 恭子, 藤田 浩司, 高橋 宏和, 小林 規俊, 稲森 正彦, 阿部 泰伸, 桐越 博之, 窪田 賢輔, 斉藤 聡, 上野 規男, 前山 史朗, 中島 淳

    日本消化器病学会雑誌   105 ( 臨増大会 )   A850 - A850   2008.9

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  • NAFLD,NASH発症におけるアンジオテンシンIIタイプ1受容体(AGTR1)の遺伝子多型解析

    米田 正人, 内山 崇, 留野 渉, 加藤 真吾, 馬渡 弘典, 飯田 洋, 野崎 雄一, 遠藤 宏樹, 藤田 浩司, 高橋 宏和, 小林 規俊, 稲森 正彦, 阿部 泰伸, 桐越 博之, 窪田 賢輔, 斉藤 聡, 前山 史朗, 堀田 紀久子, 上野 規男, 中島 淳

    日本消化器病学会雑誌   105 ( 臨増大会 )   A846 - A846   2008.9

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  • 膀胱癌におけるSema4D/PlexinB1/METの発現とその機能解析

    加藤 真吾, 中井川 昇, 石黒 斉, 矢尾 正祐, 窪田 吉信

    日本癌学会総会記事   64回   384 - 384   2005.9

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    J-GLOBAL

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Presentations

  • 臨床検査としてのがん遺伝子パネル検査の現状と課題

    加藤真吾, 鈴木章浩, 中島淳

    第106回日本消化器病学会総会  2020.8 

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    Event date： 2020.8

    Presentation type：Symposium, workshop panel (public)  

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  • GenMineTOP（二刀流パネル）におけるTIPS

    加藤真吾

    第62回 日本癌治療学会学術講演会  2024.10 

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  • GenMineTOP がんゲノムプロファイリングシステムにおけるRNA解析の実際と有用性の検討

    加藤真吾

    第32回日本消化器関連学会週間 JDDW2024  2024.11 

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  • ポストがんゲノム時代におけるRNA sequence臨床応用の可能性についての検討

    加藤真吾

    第31回日本消化器関連学会週間 JDDW2023  2023.11 

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Awards

  • 令和５年理事長・学長表彰（教職協働・職員部門）

    2024.3   公立大学法人横浜市立大学   「がんゲノム医療拠点病院」及び「がんゲノム医療連携病院」の運営開始

    附属病院, がんゲノム診断科, 医学, 病院企画課, センター病院, がんゲノム診療科, 患者総合サポートセンター, が, 包括センター担当

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  • 令和５年理事長・学長表彰（教員部門） 優秀賞

    2024.3   公立大学法人横浜市立大学   がんゲノム医療拠点病院指定への貢献

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  • 第25回日本がん分子標的治療学会学術集会 優秀演題賞

    2021.5   日本がん分子標的治療学会   局所免疫反応及び薬物応答の解析が可能な胆のうがん患者モデルマウスの構築

    加藤真吾

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  • 若手奨励賞

    2019.11   日本消化器関連学会機構   ヒト膵癌の多段階発癌を模倣するマウス膵癌オルガノイド細胞株セットを用いた 早期診断マーカーの探索

    加藤真吾

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  • Poster of Distinction

    2019.5   Digestive Disease Week   DEVELOPMENT OF A NOVEL GALLBLADDER CANCER MOUSE MODEL USING ORGANOID CELL LINES

    KATO Shingo

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  • Young Researcher Award

    2018.11   Japan Digestive Disease Week   Functional analysis of variant of unknown significance in cancer clinical sequence using human organoid cell lines

    KATO Shingo

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  • FARE (Fellows Award for Research Excellence)

    2014.11   National Institute of Health, USA  

    KATO Shingo

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  • Federal Technology Transfer award

    2014.4   National Institute of Health, USA  

    KATO Shingo

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  • Excellent poster award

    2010.10   Japan Digestive Disease Week  

    KATO Shingo

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  • Japan Biliary Association Award

    2010.5   Japan Biliary Association  

    KATO Shingo

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Research Projects

  • がん薬物療法感受性予測因子としての高感度相同組換え修復異常検査の開発

    2025.4 - 2028.3

    横浜市立大学  学長裁量事業 第6期戦略的研究推進事業「オープン・イノベーション・アカデミアプロジェクト」 

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  • 膵臓がんマウスモデル作成についてのオルガノイド組織の膵臓移植に関するアドバイス

    2025.4 - 2025.5

    受託研究費 

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  • 膵癌を対象とした高感度相同組換え修復異常検査の開発を目指した基礎的解析

    2024.8 - 2025.8

    横浜総合医学振興財団  令和6年度 がん研究助成 

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  • イチジク由来成分ベンズアルデヒドを用いた効果的ながん治療法の開発

    2024.4 - 2025.3

    横浜学術教育振興財団  2024年度 研究助成 

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  • 内在性プロモーター下融合遺伝子導入による粘液型脂肪肉腫モデルの開発

    Grant number：23K08592  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    竹山 昌伸, 加藤 真吾, 加藤 生真

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    Authorship：Coinvestigator(s) 

    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

    本研究では、FUS-DDIT3融合遺伝子を特徴とする粘液型脂肪肉腫に着目し、オルガノイド培養技術とCRISPR CAS9によるゲノム編集技術を用いて、免疫能と薬物代謝能が正常なマウスを宿主とするがんモデルを構築する。融合遺伝子の導入では、外来遺伝子は導入せず、マウスの内在性プロモーター下に転座を誘導する。令和5年度は、内在性プロモーター下にFUS-DDIT3を誘導する手法を確立するため、主に最適なガイドRNAの条件検討を行った。ガイドRNAの候補を、複数設計し、ガイドRNAとCAS9タンパク質をDNAベクターを用いて、リポフェクションにより細胞に導入した。導入細胞は、当初は計画通りオルガノイドを用いていたが、導入効率が悪かったため、マウス線維芽細胞の、3T3L1細胞に変更した。今年度内に、内在性ゲノムで目的の融合遺伝子が導入出来たことをPCRで確認した。また、ウエスタンブロッティングにより、タンパク質レベルでも、目的の融合遺伝子由来のタンパク質の発現を確認した。現在、限界希釈法により、シングルセルクローニングを試みている。現状まだ完全に単一クローンと呼べる株は得られていない。計画書に記載した、b) 成熟マウスにおけるPrrx1発現組織のスクリーニング、c) 軟部組織オルガノイドの樹立 に関しては、現状では優先度が低いので、いったん延期とする。次年度は、現状得られている株で、計画通りの方針とする。年度内にさらに進むようであれば戻ってこれらの解析も追加する。

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  • 精密がん患者モデルを用いた膵癌新規がん免疫療法の開発

    Grant number：22K08035  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    加藤 真吾, 鈴木 章浩

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    Authorship：Principal investigator 

    Grant amount：\4030000 （ Direct Cost: \3100000 、 Indirect Cost：\930000 ）

    本研究の目的は、がんゲノム変異に最適化した膵癌の新規がん免疫療法を開発することである。①腫瘍浸潤免疫細胞の詳細な解析、②がん免疫療法の標的として適切なシグナル経路の同定、③当該シグナル経路を標的とした治療の効果検証という流れで研究を計画している。令和4年度は、膵癌の中で最も多いがんゲノム変異であるKRAS変異＋TP53変異（K53膵癌）と、TP53野生型膵癌の中で最も頻度が高いKRAS変異＋SMAD4変異（KS4膵癌）を用いて解析を進めた。それぞれの膵癌の腫瘍局所で優位に作用している免疫調節細胞を解析した結果、骨髄由来抑制細胞（MDSC）のサブセットの一種がK53膵癌で優位に増加していた。令和5年度は、がん免疫療法の標的として適切なシグナル経路の探索を行うために、K53膵癌とKS4膵癌の網羅的遺伝子発現解析をRNA sequenceにより行った。2種のがんで発現量の異なる遺伝子は多数検出されたが、シグナル解析に落とし込むと、細胞接着や代謝経路に関わるものが多く、免疫細胞との相互作用を検討できる経路は同定されてなかった。そこで、KRAS変異のみを導入した膵管上皮オルガノイド（K膵管）を解析対象に加えた。K膵管は、膵癌の前がん病変として知られる膵上皮内腫瘍性病変（pancreatic intraepithelial neoplasia：PanIN）を想定したオルガノイドである。K53膵癌とK膵管でRNA sequenceにより網羅的遺伝子発現解析を行い、癌と前がん病変での発現変動遺伝子を比較した。ここでも、多くの発現変動遺伝子は検出されたが、シグナル経路解析では、特徴的なものを認めなかった。そこで、それぞれの2群間で発現変動の大きいサイトカイン・ケモカインに着目し、以後の解析を進める方針とした。

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  • 膵癌における腫瘍関連マクロファージのマスター転写因子を標的とした新規治療法への探索研究

    2022.4 - 2025.3

    日本医療研究開発機構（AMED）  次世代がん医療加速化研究事業 

    田村智彦(代)

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    Authorship：Coinvestigator(s) 

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  • オルガノイドを活用したPTEN遺伝子VUSの新規評価法の確立

    2022.4 - 2025.3

    日本医療研究開発機構（AMED） 

    筆宝義隆

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    Authorship：Coinvestigator(s) 

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  • がん薬物療法感受性予測因子としての高感度相同組換え修復異常検査の開発

    2022.4 - 2024.3

    横浜市立大学  令和4年度学長裁量事業（学術研究推進持病）「YCU未来共創プロジェクト」 

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  • ヒトオルガノイド細胞株を用いたがんクリニカルシークエンス意義不明変異の機能評価法の確立

    2021.8 - 2022.8

    横浜総合医学振興財団  令和3年度 推進研究助成 

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    Authorship：Principal investigator 

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  • 癌細胞の遺伝子変異に最適化した新規膵癌免疫療法の開発

    2020.4 - 2023.3

    日本膵臓病研究財団  研究助成 

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    Authorship：Principal investigator 

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  • AMPA受容体シグナル伝達系に着目した新規膵癌治療法の開発

    2020.4 - 2023.3

    武田科学振興財団  研究助成 

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    Authorship：Principal investigator 

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  • 通常型膵癌に腫瘍浸潤T細胞を増加させる新規免疫療法の開発

    Grant number：19K16840  2019.4 - 2021.3

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    加藤 真吾

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    Authorship：Principal investigator 

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • Examination of synergy effect by aspirin and metformin combination in colon carcinogenesis model

    Grant number：17K15602  2017.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Arimoto Jun, Higurashi Takuma, Kato Shingo, Nakajima Atsushi, Komiya Yasuhiko

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    Authorship：Coinvestigator(s) 

    Grant amount：\3380000 （ Direct Cost: \2600000 、 Indirect Cost：\780000 ）

    The incidence of colorectal cancer (CRC) continues to increase in morbidity and mortality worldwide, and the importance of urgent measures is growing. Chemoprevention has attracted attention as a measure against colorectal cancer, and we examined whether the combination of aspirin and metformin enhance the preventive effect than single agent administration in this study. We performed a four-group comparison (control group, aspirin group, metformin group, combination group) using colon carcinogenesis model mice. We administered the carcinogen (Azoxymethane) to mice of each group, and we compared the number of ACFs (Aberrant Crypt Foci) considered to be precancerous lesion in mice. The result showed that the number of ACFs in the combination group was smaller than that in the control group, aspirin group, and metformin group.

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  • タンパク質・ペプチド修飾解析による早期がん・リスク疾患診断のための血液バイオマーカーの開発

    2016.4 - 2022.3

    日本医療研究開発機構（AMED）  次世代がん医療創生研究事業 

    本田一文

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    Authorship：Coinvestigator(s) 

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Teaching Experience

  • 医学科１年生リメディアル科目「生命のしくみを考える」

    2025.6

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  • 医学部3年生 リサーチクラークシップ 肝胆膵消化器病学

    2025.4 - 2025.7

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  • 横浜市立大学全学部混合一年 総合ゼミ

    2025.4 - 2025.7

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  • 医学科1年 医療と社会

    2025.4

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