Updated on 2025/08/01

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写真a

 
Shigeru Aoki
 
Organization
YCU Medical Center Perinatal Center Associate Professor
Title
Associate Professor
Homepage
http://www.uraboshi.jp/
External link

Degree

  • 博士（医学） ( 横浜市立大学 )

Research Interests

  • 妊産婦合併症

  • 周産期医学

Research Areas

  • Life Science / Obstetrics and gynecology

Papers

  • Impact of introducing the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria on pregnancy outcomes in Japan. Reviewed

    Ryosuke Shindo, Shigeru Aoki, Junko Kasai, Yusuke Saigusa, Sayuri Nakanishi, Etsuko Miyagi

    Endocrine journal   67 ( 1 )   15 - 20   2020.1

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    To estimate pregnancy complications in women newly diagnosed with gestational diabetes mellitus (GDM) according to the new International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria and verify the validity of introducing the IADPSG criteria in Japan. This retrospective study included data from women with singleton delivery at 22 weeks or later at a tertiary hospital during 2000-2009. We compared pregnancy outcomes between women who would now be diagnosed with GDM according to the IADPSG criteria but not by the old JSOG criteria (IGT group, n = 503) and women with normal glucose tolerance according to both the criteria (NGT group, n = 2,789). Multivariate analysis was performed and adjusted for background factors. Maternal age at delivery and pre-pregnancy BMI were significantly higher in the IGT group than in the NGT group, while gestational weeks at delivery did not differ between the groups. No difference was observed in the rates of GDM-related composite complications (defined as cases with at least one of the following: macrosomia, shoulder dystocia, neonatal hypoglycemia, neonatal hyperbilirubinemia, or neonatal respiratory distress syndrome) at 11.9% and 8.8% (adjusted odds ratio (OR) 1.30, 95% confidence interval (CI) 0.90-1.87, p = 0.16). Pregnancy outcomes did not differ significantly between the IGT and NGT groups, except for frequencies of total neonatal admissions at 10.5% and 7.1%, respectively (adjusted OR 1.55, 95% CI 1.12-2.13, p < 0.01).

    DOI： 10.1507/endocrj.EJ19-0279

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  • Perinatal outcomes of recurrent placental abruption. Reviewed International journal

    Tomoyuki Kojima, Mio Takami, Ryosuke Shindo, Yusuke Saigusa, Etsuko Miyagi, Shigeru Aoki

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   34 ( 13 )   1 - 5   2019.9

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    Introduction: The purpose of this study was to classify patients with placental abruption (PA) into those with a history of PA (recurrence group) and those without a history (first-occurrence group), and compare the two groups to investigate whether perinatal outcomes differ between first-time PA and recurrent PA. Materials and methods: Subjects include 6475 patients diagnosed with PA from the Pregnancy Birth Registry System of the Japan Society of Obstetrics and Gynecology. Patients were classified into recurrence group and first-occurrence group. Perinatal outcomes were compared between 141 patients in the recurrence group and 705 patients in the first-occurrence group with 1:5 propensity score matching, adjusting for maternal age, history of smoking, pregnancy-induced hypertension, and premature rupture of membranes as covariates. Results: There were no cases of maternal mortality in either groups, and the perinatal mortality rate did not exhibit a significant difference. Gestational age at delivery was significantly earlier in the recurrence group than in the first-occurrence group (35.3 vs 37.9 weeks, p < .001). The rate of preterm delivery at less than both 32 and 37 weeks of gestation was significantly higher in the recurrence group. The rate of UmApH < 7.1 and 5 min Apgar score < 7 were significantly higher in the recurrence group (21 vs 13%, p = .020, 20% vs 10%, p = .003, respectively). Conclusions: The results suggest that recurrent PA occurs at an earlier gestational age and follows a more severe course than the first occurrence of PA.

    DOI： 10.1080/14767058.2019.1660766

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  • Does pre-eclampsia without proteinuria lead to different pregnancy outcomes than pre-eclampsia with proteinuria? Reviewed International journal

    Azusa Tochio, Soichiro Obata, Yusuke Saigusa, Ryosuke Shindo, Etsuko Miyagi, Shigeru Aoki

    The journal of obstetrics and gynaecology research   45 ( 8 )   1576 - 1583   2019.8

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    AIMS: The Japanese Society for the Study of Hypertension in Pregnancy revised the diagnostic criteria for pre-eclampsia (PE) to conform to those of the International Society for the Study of Hypertension in Pregnancy (ISSHP) in 2018. This study aimed to investigate whether pregnancy outcomes differ based on the presence of proteinuria and validate the adoption of the ISSHP criteria in Japan. METHODS: This is a retrospective study involving 308 women diagnosed with hypertensive disorders of pregnancy at a tertiary center. They were divided into the following groups: PE with proteinuria (n = 218), PE without proteinuria (n = 45) and gestational hypertension (n = 45) according to the ISSHP criteria for comparison of pregnancy outcomes. RESULTS: Applying the ISSHP criteria increased the number of pregnant women diagnosed as having PE by 14.6% (45 women). The difference in the rate of composite maternal complications between the two groups was unremarkable, with 33 cases (15.1%) in the PE with proteinuria group and 9 cases (20%) in the PE without proteinuria group. Moreover, composite neonatal complications occurred in 37 cases (17%) of PE with proteinuria group and 6 cases (13.3%) of PE without proteinuria group, showing remarkably similar incidence rate in the two groups. Women with PE with and without proteinuria had significantly earlier deliveries and lower neonatal birth weight than those with gestational hypertension. CONCLUSION: Pregnancy outcomes of PE with and without proteinuria were almost similar although their incidence increased, confirming its validity for adaptation of the ISSHP criteria in Japan.

    DOI： 10.1111/jog.14017

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  • Case of decidual discharge from the nonpregnant uterine cavity of the bicorporeal uterus before onset of delivery. Reviewed International journal

    Obata S, Noguchi T, Chiba S, Miyagi E, Aoki S

    The journal of obstetrics and gynaecology research   45 ( 7 )   1410 - 1413   2019.7

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    A 30-year-old woman with a bicorporeal uterus complained of abdominal pain and vaginal hemorrhage at 28 weeks and 5 days of gestation. There were no signs of placenta previa with echography in the second trimester; however, the echography showed a highly echoic area (91 × 85 mm), indicating placenta previa. Thereafter, abdominal pain and vaginal bleeding increased. Thus, we suspected placental abruption and performed cesarean section. After cesarean section, discharge of placenta-like tissue into the vagina was confirmed and pathological examination of the tissue showed only the decidua. In cases of uterine malformations, in which the uterine cavity is divided into pregnant and nonpregnant sides, the decidua on the nonpregnant side can be discharged before the onset of delivery. In addition, at the time of decidual discharge, echography findings are similar to those of placenta previa and the clinical symptoms are similar to those of placental abruption.

    DOI： 10.1111/jog.13971

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  • Massive subchorionic hematoma (Breus' mole) presents a variety of ultrasonic appearances: A case report and literature review. Reviewed International journal

    Yanagisawa F, Aoki S, Odagami M, Miyagi E

    Clinical case reports   7 ( 4 )   744 - 748   2019.4

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    Massive subchorionic hematoma (MSH) presents a variety of ultrasonic appearances. Placentomegaly with fetal growth restriction should be included as one of the differential diagnoses for intraplacental MSH. Care management of MSH requires to be tailored to each individual's responses while taking the NICU's capabilities and the patient's wishes into consideration.

    DOI： 10.1002/ccr3.2036

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  • Adverse pregnancy outcomes related to preterm cesarean delivery. Reviewed International journal

    Kino T, Yamamoto Y, Saigusa Y, Aoki S, Miyagi E

    European journal of obstetrics, gynecology, and reproductive biology   234   89 - 91   2019.3

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    OBJECTIVE: Cesarean delivery at a preterm gestational age has been related to maternal complications such as bleeding and infection. However, previous reports are conflicting, and there is no consensus on the matter. We aimed to clarify the adverse effect of preterm cesarean delivery with an emphasis on maternal bleeding. STUDY DESIGN: We conducted a retrospective study comparing the frequency of maternal adverse outcome between preterm emergency cesarean delivery and term emergency cesarean delivery. Nine hundred and forty seven preterm cases and 1056 full-term cases were included in the study. We analyzed the frequency of abnormal bleeding defined as 1500 mL or more as primary outcome, blood transfusion rate, and rate of postoperative administration of antibiotics as secondary outcome. Logistic regression analysis was performed for confounding variables; age at delivery, primiparity, obesity, prior history of uterine surgery, abnormal placental position, abnormal glucose tolerance, hypertension during pregnancy, early rupture of membranes, and general anesthesia use during operation. As secondary analysis, to study the effects of method of incision, we compared adverse outcomes among classical cesarean delivery, inverted T incision, and upper segment incision within preterm emergency cesarean delivery. RESULTS: Preterm cesarean delivery had significantly higher rates of abnormal bleeding, transfusion and use of antibiotics than term cesarean delivery. Among the preterm delivery, classical incision was related to increased rate of blood transfusion and need for antibiotic treatment. CONCLUSION: Preterm cesarean delivery increases the risk of maternal bleeding. This should be considered especially in the setting of early preterm birth.

    DOI： 10.1016/j.ejogrb.2018.12.033

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  • Efficacy of expectant management of severe preeclampsia and preeclampsia superimposed on chronic hypertension before 34 weeks gestation. Reviewed International journal

    Hoshino A, Obata S, Tochio A, Seki K, Miyagi E, Aoki S

    Pregnancy hypertension   15   177 - 180   2019.1

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    OBJECTIVES: To investigate the effect of chronic hypertension on expectant management for preeclampsia (PE). STUDY DESIGN: Pregnant women who were diagnosed with severe PE before 34 weeks of gestation between 2005 and 2016 and managed at a tertiary center were the subjects of the study. Mothers were classified into two groups: a severe superimposed PE (SSP) group and a severe PE (SP) group. We compared the groups in terms of perinatal outcomes. MAIN OUTCOME MEASURES: Pregnancy prolongation from the diagnosis of severe PE to delivery. RESULTS: The SSP group included 30 women whereas the SP group included 79 women. Expectant management could be performed in 24 subjects (80.0%) in the SSP group and 49 (62.0%) in the SP group (P = 0.110). Gestational age at diagnosis of PE (P = 0.016) and gestational age at delivery (P = 0.031) were significantly lower in the SSP group than in the SP group. There were no significant differences between the groups in terms of pregnancy prolongation (SSP, 8.5 days versus SP, 6.0 days; P = 0.25) or maternal and neonatal complications. CONCLUSIONS: Compared to severe PE, severe PE superimposed on chronic hypertension does not increase the prevalence of maternal complications, and an equivalent pregnancy prolongation was obtained. Expectant management was possible in severe superimposed PE on chronic hypertension, as it was in severe PE.

    DOI： 10.1016/j.preghy.2019.01.007

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  • Genital Ulcer of Behçet Disease Localized in the Vagina May Lack Pain, Making It Difficult to Assess. Reviewed International journal

    Obata S, Kobayashi K, Toda M, Miyagi E, Aoki S

    Case reports in rheumatology   2019   2953676 - 2953676   2019

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    Genital ulcer is one of the main clinical symptoms of Behçet disease; ulcers mostly occur in the vulva and are usually quite painful. We present an unusual case of Behçet disease wherein a painless genital ulcer was localized in the vagina. Our case is of a 43-year-old woman diagnosed with Behçet disease that was controlled with prednisolone. She became pregnant and developed fever, oral ulcers, and arthralgia at 16 weeks of gestation. Although a relapse of Behçet disease was suspected, ulceration and pain of the vulva were not observed. At 18 and 28 weeks of gestation, a vaginal ulcer was observed during regular prenatal examination, but the patient had no pain or other symptoms in the vulva. The vaginal ulcer healed at 29 weeks of gestation. No recurrence of the vaginal ulcer and other symptoms of Behçet disease were seen on subsequent follow-up examination at 1 month after delivery. Although genital ulcers of Behçet disease are common in the vulva and are generally painful, if they are located in the vagina, they can be painless. If Behçet disease is suspected based on other symptoms, a vaginal examination should be conducted as necessary for accurate evaluation of Behçet disease.

    DOI： 10.1155/2019/2953676

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  • Comprehensive medical treatment of women with Turner syndrome may improve pregnancy outcomes: A case report. Reviewed

    Soichiro Obata, Taku Tsuburai, Ryosuke Shindo, Shigeru Aoki, Etsuko Miyagi, Hideya Sakakibara

    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology   28 ( 2 )   37 - 41   2019

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    A 35-year-old primiparous woman was diagnosed with Turner syndrome at the age of 12 yr due to short stature. Her karyotype showed a mosaic pattern [45, X(19)/46, XX(11)]. She had been followed up by the pediatric service. GH was not prescribed because, although she was of relatively short stature, her growth trajectory was reasonable. She was started on estrogen replacement therapy at 15 yr of age and switched to Kaufmann therapy after 1 yr. After transitioning her care to the gynecology service at 20 yr of age, she was screened for complications and Kaufmann therapy was continued. No abnormalities were detected in the pre-pregnancy screening. She conceived by in vitro fertilization and embryo transplantation with oocyte donation. No severe complications occurred during gestation, and she gave birth to a female neonate vaginally at 41 wk and 6 d of gestation. The neonate's birthweight was 3166 g, and her Apgar scores were 8 and 9 at 1 and 5 min, respectively. No severe complications occurred during the postpartum period. Comprehensive medical treatment and appropriate transition from pediatric to adult services may improve the pregnancy outcomes of women with Turner syndrome.

    DOI： 10.1297/cpe.28.37

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  • Effects of physical activity during pregnancy on preterm delivery and mode of delivery: The Japan Environment and Children's Study, birth cohort study Reviewed

    Mio Takami, Akiko Tsuchida, Ayako Takamori, Shigeru Aoki, Mika Ito, Mika Kigawa, Chihiro Kawakami, Fumiki Hirahara, Kei Hamazaki, Hidekuni Inadera, Shuichi Ito, Toshihiro Kawamoto, Hirohisa Saito, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Zentaro Yamagata, Michihiro Kamijima, Takeo Nakayama, Hiroyasu Iso, Masayuki Shima, Yasuaki Hirooka, Narufumi Suganuma, Koichi Kusuhara, Katoh Takahiko

    PLoS ONE   13 ( 10 )   e0206160   2018.10

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    DOI： 10.1371/journal.pone.0206160

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  • Should the IADPSG criteria be applied when diagnosing early-onset gestational diabetes? Reviewed

    Yuko Hagiwara, Junko Kasai, Sayuri Nakanishi, Yusuke Saigusa, Etsuko Miyagi, Shigeru Aoki

    Diabetes Research and Clinical Practice   140   154 - 161   2018.6

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.diabres.2018.03.048

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  • Optimal weight gain in obese and overweight pregnant Japanese women. Reviewed

    Junko Hirooka-Nakama, Kimiko Enomoto, Kentaro Sakamaki, Kentaro Kurasawa, Etsuko Miyagi, Shigeru Aoki

    Endocrine journal   65 ( 5 )   557 - 567   2018.5

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    We aimed to determine the optimal gestational weight gain (GWG) in Japanese women with a Body Mass Index (BMI) ≥25 kg/m2. The present retrospective study investigated singleton pregnancies in 6,781 Japanese women registered in the Japan Society of Obstetrics and Gynecology system in 2013. We divided overweight and obese women into four GWG categories based on the Institute of Medicine (IOM) recommended: weight loss, small weight gain, within IOM criteria, and above IOM criteria. The adjusted odds ratios and predicted probabilities of maternal and neonatal outcomes of interest with weight change were calculated. In overweight women, GWG was associated with neonatal birth weight. In the loss and small gain subgroups, there was a significant increase in small for gestational age (SGA) and low birth weight neonates (LBW). Predicted probabilities showed the lowest risk was observed in a weight gain of 0 kg; the risk sharply increased at a gain of 11.5 kg. In obese women, weight gain increased the prevalence of large for gestational age (LGA) neonates; however; SGA was not associated with GWG. Predicted probabilities showed an increase in the risk with weight gain. The observed optimal GWG was 0 to 11.5 kg in overweight, and weight loss in obese, pregnant Japanese women.

    DOI： 10.1507/endocrj.EJ18-0027

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  • Clinical significance of low result of 1-h 50-g glucose-challenge test in pregnant women. Reviewed

    Oawada N, Aoki S, Sakamaki K, Obata S, Seki K, Hirahara F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   1 - 4   2018.1

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  • Hygroscopic dilators vs balloon catheter ripening of the cervix for induction of labor in nulliparous women at term: Retrospective study Reviewed

    Ryosuke Shindo, Shigeru Aoki, Naohiro Yonemoto, Yuriko Yamamoto, Junko Kasai, Michi Kasai, Etsuko Miyagi

    PLOS ONE   12 ( 12 )   e0189665   2017.12

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    DOI： 10.1371/journal.pone.0189665

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  • Management of fetal death complicated by placenta previa during the midtrimester. Reviewed International journal

    Sayuri Nakanishi, Ryosuke Shindo, Shigeru Aoki

    Clinical case reports   5 ( 7 )   1111 - 1114   2017.7

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    Expectant management of fetal death complicated by placenta previa occurring during midtrimester trimester may induce fetal/placental atrophy and decrease uterine blood flow to facilitate vaginal delivery. Our experience with these cases suggests that about 4 weeks of expectant management should be considered as a management strategy.

    DOI： 10.1002/ccr3.1012

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  • Association of antenatal antithrombin activity with perinatal liver dysfunction: A prospective multicenter study Reviewed

    Mamoru Morikawa, Hirotada Suzuki, Mana Obata-Yasuoka, Michi Kasai, Hiroaki Itoh, Akihide Ohkuchi, Hiromi Hamada, Shigeru Aoki, Naohiro Kanayama, Hisanori Minakami

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 ( 7 )   1378 - 1386   2017.7

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    DOI： 10.1111/jgh.13714

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  • Incidence and pregnancy outcomes of superimposed preeclampsia with or without proteinuria among women with chronic hypertension Reviewed

    Sayuri Nakanishi, Shigeru Aoki, Ami Nagashima, Kazuo Seki

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   7   39 - 43   2017.1

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    DOI： 10.1016/j.preghy.2017.01.001

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  • Emergent Uterine Arterial Embolization Using N-Butyl Cyanoacrylate in Postpartum Hemorrhage with Disseminated Intravascular Coagulation Reviewed

    Soichiro Obata, Michi Kasai, Junko Kasai, Kazuo Seki, Zenjiro Sekikawa, Izumi Torimoto, Shigeo Takebayashi, Fumiki Hirahara, Shigeru Aoki

    BIOMED RESEARCH INTERNATIONAL   2017   1562432   2017

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    DOI： 10.1155/2017/1562432

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  • Expectant Management Leading to Successful Vaginal Delivery following Intrauterine Fetal Death in a Woman with an Incarcerated Uterus. Reviewed International journal

    Masafumi Yamamoto, Mio Takami, Ryosuke Shindo, Michi Kasai, Shigeru Aoki

    Case reports in obstetrics and gynecology   2017   2635275 - 2635275   2017

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    Expectant management leads to successful vaginal delivery following intrauterine fetal death in a woman with an incarcerated uterus. Management of intrauterine fetal death in the second or third trimester of pregnancy in women with an incarcerated uterus is challenging. We report a case of successful vaginal delivery following intrauterine fetal death by expectant management in a woman with an incarcerated uterus. In cases of intrauterine fetal death in women with an incarcerated uterus, vaginal delivery may be possible if the incarceration is successfully reduced. If the reduction is impossible, expectant management can reduce uterine retroversion, thereby leading to spontaneous reduction of the incarcerated uterus. Thereafter, vaginal delivery may be possible.

    DOI： 10.1155/2017/2635275

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  • Effect of transarterial embolization for post-partum hemorrhage on subsequent pregnancy Reviewed

    Yuko Nakamura, Shigeru Aoki, Shigeo Takebayashi, Fumiki Hirahara

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   42 ( 9 )   1186 - 1189   2016.9

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    DOI： 10.1111/jog.13029

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  • Systemic lupus erythematosus: Strategies to improve pregnancy outcomes Reviewed

    Yuriko Yamamoto, Shigeru Aoki

    International Journal of Women's Health   8   265 - 272   2016.7

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    Language：English   Publisher：Dove Medical Press Ltd  

    DOI： 10.2147/IJWH.S90157

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  • Spontaneous reduction of an incarcerated gravid uterus in the third trimester. Reviewed

    Takami M, Hasegawa Y, Seki K, Hirahara F, Aoki S

    Clinical case reports   4 ( 6 )   605 - 610   2016.6

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  • Seizures associated with Lupus during pregnancy. Reviewed

    Aoki S, Kobayashi N, Mochimaru A, Takahashi T, Hirahara F

    Clinical case reports   4 ( 4 )   366 - 368   2016.4

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  • Preterm premature rupture of membrane after polypectomy using an Endoloop polydioxanone suture II(™). Reviewed

    Aoki S, Hayashi M, Seki K, Hirahara F

    Clinical case reports   4 ( 4 )   331 - 332   2016.4

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  • Status epilepticus due to brain tumor during pregnancy. Reviewed

    Kasai M, Aoki S, Kobayashi N, Hirahara F, Takahashi T

    Clinical case reports   4 ( 4 )   333 - 335   2016.4

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  • A monochorionic diamniotic twin pregnancy requiring termination due to maternal anemia caused by bleeding from chronic abruption. Reviewed

    Nagashima A, Aoki S, Seki K, Hirahara F

    Clinical case reports   4 ( 4 )   320 - 322   2016.4

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  • Relationship Between Short Umbilical Cord Length and Adverse Pregnancy Outcomes Reviewed

    Yuriko Yamamoto, Shigeru Aoki, Mari S. Oba, Kazuo Seki, Fumiki Hirahara

    FETAL AND PEDIATRIC PATHOLOGY   35 ( 2 )   81 - 87   2016.3

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    DOI： 10.3109/15513815.2015.1122126

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  • Pregnancy Outcomes Based on Pre-Pregnancy Body Mass Index in Japanese Women. Reviewed International journal

    Kimiko Enomoto, Shigeru Aoki, Rie Toma, Kana Fujiwara, Kentaro Sakamaki, Fumiki Hirahara

    PloS one   11 ( 6 )   e0157081   2016

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    OBJECTIVE: To verify whether body mass index (BMI) classification proposed by the Institute of Medicine (IOM) is valid in Japanese women. METHOD: A study was conducted in 97,157 women with singleton pregnancies registered in the Japan Society of Obstetrics and Gynecology (JSOG) Successive Pregnancy Birth Registry System between January 2013 and December 2013, to examine pregnancy outcomes in four groups stratified by pre-pregnancy BMI category according to the 2009 criteria recommended by the Institute of Medicine (IOM). The groups comprised 17,724 underweight women with BMI <18.5, 69,126 normal weight women with BMI 18.5-24.9, 7,502 overweight women with BMI 25-29.9, and 2,805 obese women with BMI ≥30. The pregnancy outcomes were also compared among subgroups stratified by a gestational weight gain below, within, and above the optimal weight gain. RESULTS: The higher the pre-pregnancy BMI, the higher the incidences of pregnancy-induced hypertension, gestational diabetes mellitus, macrosomia, cesarean delivery, postpartum hemorrhage, and post-term birth, but the lower the incidence of small for gestational age (SGA). In all pre-pregnancy BMI category groups, excess gestational weight gain was associated with a higher frequency of large for gestational age and macrosomia; poor weight gain correlated with a higher frequency of SGA, preterm birth, preterm premature rupture of membranes, and spontaneous preterm birth; and optimal weight gain within the recommended range was associated with a better outcome. CONCLUSION: The BMI classification by the IOM was demonstrated to be valid in Japanese women.

    DOI： 10.1371/journal.pone.0157081

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  • Acute respiratory failure due to thyroid storm developing immediately after delivery. Reviewed

    Kitazawa C, Aoki S, Takahashi T, Hirahara F

    Clinical case reports   3 ( 12 )   997 - 999   2015.12

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  • Clinical characteristics of mirror syndrome: a comparison of 10 cases of mirror syndrome with non-mirror syndrome fetal hydrops cases. Reviewed

    Hirata G, Aoki S, Sakamaki K, Takahashi T, Hirahara F, Ishikawa H

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   29 ( 16 )   1 - 5   2015.10

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  • Acute polyhydramnios after maternal status epilepticus. Reviewed International journal

    Ryosuke Shindo, Shigeru Aoki, Michi Kasai, Tsuneo Takahashi, Fumiki Hirahara

    Clinical case reports   3 ( 8 )   707 - 9   2015.8

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    Maternal status epilepticus can cause fetal hypoxic ischemic encephalopathy that in turn results in acute polyhydramnios caused by fetal dysphagia; thus, acute polyhydramnios is a symptom that should lead to a suspicion of fetal dysphagia caused by hypoxic ischemic encephalopathy.

    DOI： 10.1002/ccr3.315

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  • Association of biparietal diameter growth rate with neurodevelopment in infants with fetal growth restriction Reviewed

    Yoshimi Hasegawa, Shigeru Aoki, Kentaro Kurasawa, Tsuneo Takahashi, Fumiki Hirahara

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   54 ( 4 )   371 - 375   2015.8

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    DOI： 10.1016/j.tjog.2014.04.031

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  • Prediction of perinatal outcomes based on primary symptoms in women with placental abruption Reviewed

    Michi Kasai, Shigeru Aoki, Miyuki Ogawa, Kentaro Kurasawa, Tsuneo Takahashi, Fumiki Hirahara

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   41 ( 6 )   850 - 856   2015.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/jog.12637

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  • Pregnancy outcomes of women with coexisting systemic lupus erythematosus flare and preeclampsia Reviewed

    Shigeru Aoki, Aya Mochimaru, Yuriko Yamamoto, Kentaro Kurasawa, Tsuneo Takahashi, Fumiki Hirahara

    MODERN RHEUMATOLOGY   25 ( 3 )   410 - 414   2015.5

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    DOI： 10.3109/14397595.2014.979522

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  • Adverse pregnancy outcomes associated with adenomyosis with uterine enlargement Reviewed

    Aya Mochimaru, Shigeru Aoki, Mari S. Oba, Kentaro Kurasawa, Tsuneo Takahashi, Fumiki Hirahara

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   41 ( 4 )   529 - 533   2015.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/jog.12604

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  • Clinical features of gestational thrombocytopenia difficult to differentiate from immune thrombocytopenia diagnosed during pregnancy Reviewed

    Junko Kasai, Shigeru Aoki, Natsuko Kamiya, Yoshimi Hasegawa, Kentaro Kurasawa, Tsuneo Takahashi, Fumiki Hirahara

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   41 ( 1 )   44 - 49   2015.1

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    DOI： 10.1111/jog.12496

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  • Effect of Umbilical Cord Entanglement and Position on Pregnancy Outcomes. Reviewed

    Kobayashi N, Aoki S, Oba MS, Takahashi T, Hirahara F

    Obstetrics and gynecology international   2015   342065   2015

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  • A classification of congenital uterine anomalies predicting pregnancy outcomes Reviewed

    Mio Takami, Shigeru Aoki, Kentaro Kurasawa, Mika Okuda, Tsuneo Takahashi, Fumiki Hirahara

    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA   93 ( 7 )   691 - 697   2014.7

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    DOI： 10.1111/aogs.12400

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  • Warfarin-associated fetal intracranial subdural hematoma: a case report. Reviewed International journal

    Fujiwara K, Aoki S, Kurasawa K, Okuda M, Takahashi T, Hirahara F

    Clinical case reports   2 ( 3 )   108 - 111   2014.6

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    KEY CLINICAL MESSAGE: We present a case in which to of fetal subdural hematoma developing despite that the maternal the prothrombin time by international normalized ratio (PT/INR) during pregnancy was within the normal range.

    DOI： 10.1002/ccr3.75

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  • Associations of maternal pre-pregnancy underweight with small-for-gestational-age and spontaneous preterm birth, and optimal gestational weight gain in Japanese women Reviewed

    Kana Fujiwara, Shigeru Aoki, Kentaro Kurasawa, Mika Okuda, Tsuneo Takahashi, Fumiki Hirahara

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   40 ( 4 )   988 - 994   2014.4

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    DOI： 10.1111/jog.12283

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  • Retrospective study of pregnant women placed under expectant management for persistent hemorrhage Reviewed

    Shigeru Aoki, Megumi Inagaki, Kentaro Kurasawa, Mika Okuda, Tsuneo Takahashi, Fumiki Hirahara

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   289 ( 2 )   307 - 311   2014.2

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    DOI： 10.1007/s00404-013-2972-z

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  • Emergency cerclage versus expectant management for prolapsed fetal membranes: A retrospective, comparative study Reviewed

    Shigeru Aoki, Emi Ohnuma, Kentaro Kurasawa, Mika Okuda, Tsuneo Takahashi, Fumiki Hirahara

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   40 ( 2 )   381 - 386   2014.2

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    DOI： 10.1111/jog.12207

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  • Expectant management of severe preeclampsia with severe fetal growth restriction in the second trimester Reviewed

    Shigeru Aoki, Rie Toma, Kentaro Kurasawa, Mika Okuda, Tsuneo Takahashi, Fumiki Hirahara

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   4 ( 1 )   81 - 86   2014.1

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    DOI： 10.1016/j.preghy.2013.11.006

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  • Significance of cervical ripening in pre-induction treatment for premature rupture of membranes at term Reviewed

    Kentaro Kurasawa, Megumi Yamamoto, Yuki Usami, Aya Mochimaru, Akihiko Mochizuki, Shigeru Aoki, Mika Okuda, Tsuneo Takahashi, Fumiki Hirahara

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   40 ( 1 )   32 - 39   2014.1

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    DOI： 10.1111/jog.12116

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  • A case of misdiagnosed cesarean scar pregnancy with a viable birth at 28 weeks. Reviewed International journal

    Nukaga S, Aoki S, Kurasawa K, Takahashi T, Hirahara F

    Case reports in obstetrics and gynecology   2014   375685 - 375685   2014

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    We report our experience with a case of presumptive cesarean scar pregnancy, based on detection of a gestational sac (GS) in early pregnancy at the site of a previous cesarean scar. The GS grew into the uterine cavity as the pregnancy progressed, showing an ultrasound image similar to that of a normal pregnancy. Thus, the pregnancy continued, resulting in a viable birth at 28 weeks of gestation. Cesarean scar pregnancy is classified as myometrial implantation or implantation growth into the uterine cavity. In the latter type, the gestational sac moves upward with increasing gestational weeks and it shows the same ultrasound image as a normal pregnancy. Therefore, the diagnosis must be made in the early pregnancy.

    DOI： 10.1155/2014/375685

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  • Circumvallate placenta: associated clinical manifestations and complications-a retrospective study. Reviewed International journal

    Hanako Taniguchi, Shigeru Aoki, Kentaro Sakamaki, Kentaro Kurasawa, Mika Okuda, Tsuneo Takahashi, Fumiki Hirahara

    Obstetrics and gynecology international   2014   986230 - 986230   2014

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    Aims. To analyze the pregnancy outcomes of circumvallate placenta retrospectively and to predict circumvallate placenta during pregnancy based on its clinical features. Methods. The pregnancy outcomes of 92 women with circumvallate placenta who delivered live singletons at a tertiary care center between January 2000 and September 2012 were compared with those of 9057 controls. Results. Women with circumvallate placenta were associated with higher incidences of preterm delivery (64.1%), placental abruption (10.9%), emergency cesarean section (45.6%), small-for-gestational age (36.9%), neonatal death (8.9%), neonatal intensive care unit admission (55.4%), and chronic lung disease (33.9%). When vaginal bleeding during the second trimester and premature chemical rupture of membranes (PCROM) were both used as predictive factors for circumvallate placenta, the sensitivity was 28.8% and specificity was 99.9%. Conclusion. With circumvallate placenta, pregnancy outcomes were poor and had characteristic clinical manifestations. In women with both vaginal bleeding and PCROM during pregnancy, circumvallate placenta should be strongly suspected.

    DOI： 10.1155/2014/986230

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