Researcher Profile - Takashi Kosaka

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写真a

Takashi Kosaka

Organization

Graduate School of Medicine Department of Medicine - Associate Professor
School of Medicine Medical Course

Homepage

http://www.ycusurg2.jp/

External link

Degree

学士(医学) ( 横浜市立大学 )
博士 ( 横浜市立大学 )

Research Interests

抗癌剤
イメージング
遺伝子治療

Research Areas

Life Science / Biomaterials
Life Science / Biomedical engineering

Research History

Yokohama City University Assistant Professor

2010

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Yokohama City University Medical Center Gastroenterological Center Assistant Professor

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Papers

Prognostic factors of second-line nivolumab monotherapy for unresectable or metastatic esophageal cancer: a multi-institutional cohort study for 184 cases.

Sho Sato, Takashi Suzuki, Takashi Chinen, Hironori Yamaguchi, Yusuke Suzuki, Nobukazu Hokamura, Zenichiro Saze, Koji Kono, Keita Takahashi, Fumiaki Yano, Tsutomu Sato, Takashi Kosaka, Itaru Endo, Yasushi Ichikawa, Yutaka Miyawaki, Hiroshi Sato, Hideaki Shimada

Journal of gastroenterology 2024.8

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BACKGROUND: The real-world efficacy, prognostic factors, and adverse events of second-line nivolumab monotherapy and subsequent third-line therapy for unresectable or metastatic esophageal cancer have not been fully evaluated. METHODS: This multi-institutional retrospective cohort study evaluated 184 consecutive patients treated with second-line nivolumab monotherapy for esophageal cancer between March 2021 and December 2022. We assessed tumor response, adverse events, long-term survival, and prognostic factors. RESULTS: Among 128 patients with measurable lesions, the response rate was 23% and the disease control rate for all enrolled patients was 45%. The incidence of grade 3 or higher adverse events was 14%, but no treatment-related deaths presented. Median progression-free survival was 5.1 months and overall survival was 14 months, respectively. C-reactive protein level and performance status were identified as significant prognostic factors of overall survival through Cox proportional hazards analysis. The group with two favorable prognostic factors showed better overall survival than the groups with either one or zero prognostic factors (median overall survival: 22, 15, and 4.4 months, respectively). Among 69 patients who received third-line taxane anticancer agents, the progression-free survival was 6.7 months. CONCLUSIONS: Our study demonstrated that the real-world outcomes of second-line nivolumab monotherapy were comparable to those of previous randomized clinical trials in terms of tumor response, safety, and long-term survival. Furthermore, a good performance status and low C-reactive protein levels may identify patients who are likely to benefit from therapy. Third-line chemotherapy after nivolumab treatment may have an enhanced effect; however, further prospective studies are required to confirm this finding.

DOI： 10.1007/s00535-024-02141-8

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The real-world data of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer: a multi-institutional cohort study.

Sho Sato, Takashi Ssuzuki, Takashi Chinen, Hironori Yamaguchi, Yusuke Suzuki, Nobukazu Hokamura, Zenichiro Saze, Koji Kono, Keita Takahashi, Fumiaki Yano, Chikara Kunisaki, Takashi Kosaka, Itaru Endo, Yasushi Ichikawa, Yutaka Miyawaki, Hiroshi Sato, Hideaki Shimada

International journal of clinical oncology 2024.4

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BACKGROUND: The real-world efficacy, feasibility, and prognostic factors of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer are not fully established. METHODS: This multi-institutional retrospective cohort study evaluated 71 consecutive patients treated with immune-checkpoint inhibitor combination therapy for esophageal cancer between March 2021 and December 2022. We assessed tumor response, safety, and long-term survival. RESULTS: In patients with measurable lesions, the response rate was 58%, and the disease control rate for all enrolled patients was 80%. Five patients (7.0%) underwent successful conversion surgery. Grade 3 or higher immune-related adverse events occurred in 13% of patients, and one patient (1.4%) died due to cholangitis. Median progression-free survival was 9.7 (95% confidence interval: 6.5-not reached). C-reactive protein levels and performance status were identified as significant predictors of progression-free survival through Cox proportional hazards analysis. CONCLUSIONS: Immune-checkpoint inhibitor combination therapy for esophageal cancer demonstrated comparable tumor response, safety, and long-term survival to previous randomized clinical trials. Patients with good performance status and low C-reactive protein levels may be suitable candidates for this treatment.

DOI： 10.1007/s10147-024-02532-0

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Ramucirumab Plus Paclitaxel as a Second-line Chemotherapy in Older Adults With Advanced Gastric Cancer (YCOG1601). International journal

Sho Sato, Chikara Kunisaki, Yuko Tamura, Akikazu Yago, Kohei Kasahara, Tsutomu Sato, Hiroki Kondo, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

Anticancer research 43 ( 12 ) 5663 - 5670 2023.12

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BACKGROUND/AIM: Ramucirumab plus paclitaxel has been widely used as a second-line chemotherapy for treating advanced gastric cancer. However, the real-world data of this regimen for older patients with gastric cancer (GC) remains unrevealed. The aim of this study was to clarify the feasibility and efficacy of this regimen for older patients with GC in a single-arm, phase II study. PATIENTS AND METHODS: Patients aged ≥70 years having unresectable or recurrent GC who met the eligible criteria were enrolled. Paclitaxel was administered at a dose of 80 mg/m2 on days 1, 8, and 15, and ramucirumab was administered at a dose of 8 mg/kg on day 1 and day 15 of a 4-week cycle. Primary endpoint was the incidence of adverse events and secondary endpoints were response rate, progression-free survival, and overall survival. A total of 25 patients were enrolled in the full-set analysis. RESULTS: Grade 3 or more adverse events were observed in 21 patients (84.0%). Neutropenia was most frequently observed (68.0%), followed by peripheral sensory neuropathy (12.0%), and febrile neutropenia (12.0%). Median progression-free survival and overall survival were 6.9 months and 13.4 months, respectively. Disease control rate was 88.0%, and response rate of patients with measurable lesions was 52.9%. Notably, no treatment-related deaths occurred. CONCLUSION: Ramucirumab plus paclitaxel as a second-line chemotherapy demonstrated acceptable oncological outcomes, despite the occurrence of frequent adverse events. It is necessary to carefully select patients and adjust treatment regimens in older patients with GC to safely administer chemotherapy and subsequently achieve satisfactory long-term outcomes.

DOI： 10.21873/anticanres.16771

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Long-term Outcomes of Neoadjuvant Chemotherapy With Docetaxel, Cisplatin and S-1 for Stage III Gastric Cancer. International journal

Kohei Kasahara, Chikara Kunisaki, Sho Sato, Hiroki Kondo, Masazumi Takahashi, Yuko Tamura, Nobuhiro Tsuchiya, Yusaku Tanaka, Kei Sato, Jun Kimura, Takashi Kosaka, Hidetaka Ono, Hirochika Makino, Hirotoshi Akiyama, Itaru Endo

Anticancer research 43 ( 6 ) 2841 - 2850 2023.6

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BACKGROUND/AIM: In the previous phase I/II study, we established neoadjuvant chemotherapy (NAC) using bi-weekly docetaxel, cisplatin, and S-1 (DCS) for clinical stage III gastric cancer. This study aimed to clarify long-term outcomes of this treatment. PATIENTS AND METHODS: Relapse-free survival (RFS) and overall survival (OS) were calculated by the Kaplan-Meier method and prognostic factors for RFS and OS were identified by univariate analysis. RESULTS: A total of 47 patients with clinical stage III gastric cancer were enrolled in this study. The 5-year RFS and OS rates were 69.8% and 74.3%, respectively, in all registered patients. Moreover, the 5-year OS and RFS rates in patients receiving R0 gastrectomy were 68.0% and 79.4%, respectively. Neutrophil-lymphocyte ratio (NLR) before NAC ≥2.41, prognostic nutritional index (PNI) before NAC ≤50.4, Glasgow prognostic score before NAC classification 2, NLR after NAC ≥1.43, PNI after NAC <48.0, and Grade 1a/1b pathological response significantly worsened RFS. NLR after NAC ≥1.43, PNI before NAC ≤50.4, NLR after NAC ≥1.43, and body weight loss >5 kg after NAC significantly worsened OS. CONCLUSION: Although bi-weekly DCS therapy as neoadjuvant setting showed acceptable long-term outcomes, poor immune-nutritional status before and after NAC caused worse long-term survival in stage III gastric cancer patients. It is warranted to conduct a well-designed prospective randomized control study to compare long-term outcomes using the bi-weekly DCS regimen between patients with and without immune-nutritional support during peri-NAC.

DOI： 10.21873/anticanres.16453

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残胃癌に対する至適リンパ節郭清範囲は? 幽門側胃切除後残胃癌に対する至適リンパ節郭清の検討

佐藤渉, 國崎主税, 松下直彦, 小倉巧也, 森田順也, 近藤裕樹, 井口健太, 前澤幸男, 笠原康平, 沼田正勝, 熊本宜文, 佐藤勉, 武田和永, 田村裕子, 小坂隆司, 秋山浩利, 遠藤格

日本胃癌学会総会記事 95回 191 - 191 2023.2

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Ball valve syndromeを来した十二指腸胃型幽門腺腫の1例

木下颯花, 小坂隆司, 大矢浩貴, 笠原康平, 中川和也, 小澤真由美, 石部敦士, 秋山浩利, 遠藤格

日本臨床外科学会雑誌 83 ( 9 ) 1670 - 1670 2022.9

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回腸憩室穿通による膿瘍形成に対して手術を施行した1例

根岸大貴, 中川和也, 木下颯花, 大矢浩貴, 笠原康平, 小澤真由美, 石部敦士, 小坂隆司, 秋山浩利, 遠藤格

神奈川医学会雑誌 49 ( 2 ) 36 - 36 2022.7

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Is Prophylactic Splenectomy Necessary for Proximal Advanced Gastric Cancer Invading the Greater Curvature with Clinically Negative Splenic Hilar Lymph Node Metastasis? A Multi-Institutional Cohort Study (YCOG2003) Reviewed

Sho Sato, Chikara Kunisaki, Hiroki Kondo, Nobuhiro Tsuchiya, Yusaku Tanaka, Masazumi Takahashi, Kei Sato, Jun Kimura, Hidetaka A. Ono, Hirochika Makino, Yuko Tamura, Kohei Kasahara, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

Annals of Surgical Oncology 29 ( 9 ) 5885 - 5891 2022.6

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Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1245/s10434-022-11939-w

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Other Link： https://link.springer.com/article/10.1245/s10434-022-11939-w/fulltext.html
ナビゲーション手術の現状と今後局所進行下部直腸癌に対する近赤外光観察併用腹腔鏡下側方郭清術の短期・中期成績

大矢浩貴, 渡邉純, 石部敦士, 武井将伍, 後藤晃紀, 諏訪雄亮, 中川和也, 諏訪宏和, 小澤真由美, 小坂隆司, 松山隆生, 秋山浩利, 遠藤格

日本臨床外科学会雑誌 82 ( 増刊 ) S101 - S101 2021.10

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Prognostic impact of dimensional factors in pT1 gastric cancer. International journal

Chikara Kunisaki, Masazumi Takahashi, Sho Sato, Nobuhiro Tsuchiya, Jun Watanabe, Tsutomu Sato, Kazuhisa Takeda, Yusaku Tanaka, Kohei Kasahara, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

Surgical oncology 38 101584 - 101584 2021.9

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BACKGROUND: The significance of the dimensional factors (tumor diameter, area and volume) as the prognostic factor has not been precisely evaluated in pT1 gastric cancer. OBJECTIVES: This study aimed to identify the clinical impact and to confirm the clinical feasibility of the dimensional factors as prognostic factors in pT1 gastric cancer. METHODS: We analyzed prognostic factors for disease-specific survival (DSS), overall survival (OS) using clinicopathological factors by univariate and multivariate analyses and the pattern of recurrence in 2011 pT1 gastric cancer (mucosal and submucosal cancers) undergoing R0 gastrectomy. The cut-off values of each dimensional factor was decided by the ROC curve. RESULTS: Cox proportional hazard regression model showed that older age (≥75) and more advanced pN stage were adverse independent prognostic factors for DSS, and revealed that older age (≥75), greater preoperative co-morbid diseases, proximal and total gastrectomy, operative method and Clavien-Dindo classification (≥grade III) were independent adverse factors for OS. Any dimensional factors were not independent prognostic factors for any survival. CONCLUSIONS: The dimensional factors do not influence both OS and DSS in pT1 gastric cancer patients and so it is difficult to apply these dimensional factors for conducting therapeutic strategies.

DOI： 10.1016/j.suronc.2021.101584

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High postoperative neutrophil-lymphocyte ratio and low preoperative lymphocyte-monocyte ratio predict poor prognosis in gastric cancer patients receiving gastrectomy with positive lavage cytology: a retrospective cohort study. International journal

Sho Sato, Chikara Kunisaki, Masazumi Takahashi, Hirokazu Kubo, Nobuhiro Tsuchiya, Kei Sato, Hiroshi Miyamoto, Yuko Tamura, Hiroki Kondo, Yusaku Tanaka, Kohei Kasahara, Takashi Kosaka, Hirotoshi Akiyama, Yusuke Saigusa, Itaru Endo

Langenbeck's archives of surgery 2021.6

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BACKGROUND: Long-term outcomes in gastric cancer patients with positive lavage cytology (CY1) are generally poor. This multi-institutional retrospective cohort study aims to evaluate the clinical significance of the neutrophil-lymphocyte ratio (NLR) and the lymphocyte-monocyte ratio (LMR) in CY1 gastric cancer patients. METHODS: A total of 121 CY1 gastric cancer patients without other non-curative factors, who underwent macroscopically curative resection, were enrolled in this study. The cutoff values of preoperative NLR (pre-NLR), postoperative NLR (post-NLR), preoperative LMR (pre-LMR), and postoperative LMR (post-LMR) were defined by the Contal and O'Quigley method as 2.3, 3.0, 2.5, and 3.2, respectively. A Cox proportional hazard model was used to identify the independent prognostic factors among NLR, LMR, and other clinicopathological factors. RESULTS: There were significant differences in the overall survival (OS) between the two groups: high post-NLR groups vs. low post-NLR group (median survival time, months) (10.9 vs. 22.8, P = 0.006) and high pre-LMR group vs. low pre-LMR group (21.3 vs. 11.0, P = 0.001). The LMR value elevated significantly after gastrectomy (P = 0.020), although not in the NLR value (P = 0.733). On multivariate analysis, high post-NLR (hazard ratio = 1.506; 95% confidence interval = 1.047-2.167; P = 0.027), low pre-LMR (1.773; 1.135-2.769, 0.012), and no postoperative chemotherapy (1.558; 1.053-2.305, 0.027) were found to be independent prognostic factors for adverse OS. CONCLUSIONS: Because a combination of high post-NLR and low pre-LMR may be an adverse prognostic marker in resectable CY1 gastric cancer patients, it is necessary to conduct a prospective trial to confirm a useful perioperative chemotherapeutic regimen for these patients.

DOI： 10.1007/s00423-021-02233-6

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Comparison of Converse Ω Anastomosis and Extracorporeal Anastomosis After Laparoscopic Distal Gastrectomy for Gastric Cancer Reviewed International journal

Nobuhiro Tsuchiya, Chikara Kunisaki, Hirokazu Kubo, Sho Sato, Yusaku Tanaka, Kei Sato, Hiroshi Miyamoto, Jun Watanabe, Kazuhisa Takeda, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo, Toshihiro Misumi

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques Publish Ahead of Print ( 4 ) 485 - 491 2021.2

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BACKGROUND: Converse Ω anastomosis is a recently developed technique of delta-shaped anastomosis for intracorporeal gastroduodenostomy to simplify the anastomotic procedures and reduce their potential risks. This study aimed to evaluate the safety and effectiveness of converse Ω anastomosis, comparing it with conventional extracorporeal Billroth-I anastomosis after laparoscopic distal gastrectomy (LDG) for gastric cancer. PATIENTS AND METHODS: Among 169 gastric cancer patients who underwent LDG with Billroth-I anastomosis anastomosis between April 2013 and March 2018, we selected 100 patients by propensity score matching (50 in the converse Ω anastomosis group and 50 in the extracorporeal anastomosis group). Patients' characteristics, intraoperative outcomes, postoperative complications, and survival time were compared between the 2 groups. RESULTS: Median anastomosis time was significantly longer in the converse Ω group than in the extracorporeal group (40.0 vs. 30.5 min, P=0.005). However, the total procedure time did not differ significantly between the groups. Intraoperative blood loss volume was significantly lower in the converse Ω group than in the extracorporeal anastomosis group (40 vs. 120 mL, P<0.001). There were no significant differences in the number of dissected lymph nodes, postoperative morbidity, mortality, or length of hospital stay. The postoperative body mass index and the prognostic nutritional index did not differ between the groups 1 year after surgery. There were no significant differences in overall survival and relapse-free survival between the 2 groups. CONCLUSIONS: Converse Ω anastomosis is feasible and safe. This novel technique can be adopted as a treatment option for reconstruction after LDG in patients with early-stage gastric cancer. Therefore, the risks and benefits of converse Ω anastomosis after LDG should be confirmed in larger cohorts.

DOI： 10.1097/sle.0000000000000906

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A Case of Gastrointestinal Stromal Tumor with a Tumor Embolus in the Portal Vein

Kohei Kasahara, Takashi Kosaka, Sho Sato, Yusaku Tanaka, Hiroshi Miyamoto, Kei Sato, Atsushi Ishibe, Hirotoshi Akiyama, Chikara Kunisaki, Naoko Udaka, Satoshi Fujii, Itaru Endo

Japanese Journal of Gastroenterological Surgery 54 ( 8 ) 505 - 513 2021

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Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Gastroenterological Surgery

DOI： 10.5833/jjgs.2020.0105

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Feasibility of totally laparoscopic total gastrectomy in obese patients with gastric cancer

Hideaki Suematsu, Chikara Kunisaki, Hiroshi Miyamato, Kei Sato, Sho Sato, Yusaku Tanaka, Norio Yukawa, Yasushi Rino, Takashi Kosaka, Itaru Endo, Munetaka Masuda

Langenbeck's Archives of Surgery 2021

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DOI： 10.1007/s00423-021-02369-5

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大動脈食道瘻に対して有茎空腸を用いたダブルトラクト再建を二期的に施行した1例

佐藤渉, 國崎主税, 小坂隆司, 秋山浩利, 土屋伸広, 佐藤圭, 湯川ひろお, 根本寛子, 内田敬二, 遠藤格

日本食道学会学術集会プログラム・抄録集 74回 412 - 412 2020.12

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Efficacy of Video-assisted Thoracoscopic Esophagectomy for Stage II/III Esophageal Cancer: Analysis Using the Propensity Scoring System. International journal

Kenta Iguchi, Chikara Kunisaki, Sho Sato, Yusaku Tanaka, Hiroshi Miyamoto, Takashi Kosaka, Kei Sato, Hirotoshi Akiyama, Itaru Endo, Norio Yukawa, Yasushi Rino, Munetaka Masuda, Takeharu Yamanaka

Anticancer research 40 ( 3 ) 1587 - 1595 2020.3

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BACKGROUND/AIM: The purpose of this study was to evaluate the usefulness of minimally invasive esophagectomy (MIE) for stage II/III esophageal cancer (EC). PATIENTS AND METHODS: We compared surgical outcomes between MIE and open esohagectomy in EC patients with pStage II/III using the propensity scoring system. RESULTS: Fifty-seven patients were classified into the MIE group and 57 patients into the open esophagectomy (OE) group. The incidence of major complications was similar between the two groups. The 5-year OS was significantly better in the MIE group (69.0% vs. 35.5%; p=0.004) and no significant difference was observed in the 5-year recurrence-free survival (RFS, 52.2% vs. 29.2%; p=0.064). Multivariate analysis showed MIE was a prognostic factor of OS (p<0.001) and RFS (p=0.032). CONCLUSION: MIE was as safe and feasible as OE, and an independent prognostic factor for OS and RFS in patients with stage II/III EC.

DOI： 10.21873/anticanres.14106

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Curative-Intent Surgery for Stage IV Advanced Gastric Cancer: Who Can Undergo Surgery and What Are the Prognostic Factors for Long-Term Survival? Reviewed

Sato S, Kunisaki C, Tanaka Y, Sato K, Miyamoto H, Yukawa N, Kosaka T, Akiyama H, Endo I, Misumi T

Annals of surgical oncology 26 ( 13 ) 4452 - 4463 2019.12

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DOI： 10.1245/s10434-019-07790-1

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Outcomes of preoperative S-1 and docetaxel combination chemotherapy in patients with locally advanced gastric cancer. Reviewed

Kosaka T, Akiyama H, Miyamoto H, Sato S, Tanaka Y, Sato K, Kunisaki C, Endo I

Cancer chemotherapy and pharmacology 83 ( 6 ) 1047 - 1055 2019.6

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DOI： 10.1007/s00280-019-03813-6

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Tumor Volume Index as a Prognostic Factor in Patients after Curative Esophageal Cancer Resection. Reviewed

Miyamoto H, Kunisaki C, Sato S, Tanaka Y, Sato K, Kosaka T, Yukawa N, Akiyama H, Saigusa Y, Endo I

Annals of surgical oncology 26 ( 6 ) 1909 - 1915 2019.6

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DOI： 10.1245/s10434-019-07308-9

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巨大小腸GISTの1切除例

小林侑華子, 小坂隆司, 藤田亮, 神田智希, 木下颯花, 布施匡啓, 鈴木紳祐, 小澤真由美, 石部敦士, 秋山浩利, 日比谷孝志, 三宅暁夫, 加藤生真, 山中正二, 大橋健一, 遠藤格

神奈川医学会雑誌 46 ( 1 ) 66 - 66 2019.1

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A Phase II Study of Tri-weekly Low-dose Nab-paclitaxel Chemotherapy for Patients with Advanced Gastric Cancer Reviewed

Sato Sho, Kunisaki Chikara, Tanaka Yusaku, Sato Kei, Miyamoto Hiroshi, Yukawa Norio, Fujii Yoshiro, Kimura Jun, Takagawa Ryo, Takahashi Masazumi, Kosaka Takashi, Akiyama Hirotoshi, Saigusa Yusuke, Taguri Masataka, Yamanaka Takeharu, Endo Itaru

ANTICANCER RESEARCH 38 ( 12 ) 6911 - 6917 2018.12

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DOI： 10.21873/anticanres.13068

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Surgical Outcomes of Reduced-Port Laparoscopic Gastrectomy Versus Conventional Laparoscopic Gastrectomy for Gastric Cancer: A Propensity-Matched Retrospective Cohort Study. Reviewed International journal

Chikara Kunisaki, Hiroshi Miyamoto, Sho Sato, Yusaku Tanaka, Kei Sato, Yusuke Izumisawa, Norio Yukawa, Takashi Kosaka, Hirotoshi Akiyama, Yusuke Saigusa, Kentaro Sakamaki, Takeharu Yamanaka, Itaru Endo

Annals of surgical oncology 25 ( 12 ) 3604 - 3612 2018.11

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DOI： 10.1245/s10434-018-6733-x

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A Phase I/II Study of NAC with Docetaxel, Cisplatin, and S-1 for Stage III Gastric Cancer Reviewed

Tanaka Yusaku, Kunisaki Chikara, Izumisawa Yusuke, Makino Hirochika, Kimura Jun, Sato Sho, Miyamoto Hiroshi, Kosaka Takashi, Ono Hidetaka A, Takahashi Masazumi, Sato Kei, Akiyama Hirotoshi, Endo Itaru

ANTICANCER RESEARCH 38 ( 10 ) 6015 - 6021 2018.10

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DOI： 10.21873/anticanres.12951

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Impact of Sarcopenia in Patients with Unresectable Locally Advanced Esophageal Cancer Receiving Chemoradiotherapy. Reviewed

Sato S, Kunisaki C, Suematsu H, Tanaka Y, Miyamoto H, Kosaka T, Yukawa N, Tanaka K, Sato K, Akiyama H, Endo I

In vivo (Athens, Greece) 32 ( 3 ) 603 - 610 2018.5

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DOI： 10.21873/invivo.11282

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Feasibility of Laparoscopy-assisted Gastrectomy for Gastric Cancer in Elderly Patients: A Case-Control Study. Reviewed International journal

Nobuhiro Tsuchiya, Chikara Kunisaki, Hirochika Makino, Jun Kimura, Ryo Takagawa, Sho Sato, Yusaku Tanaka, Kei Sato, Hiroshi Miyamoto, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo, Kentaro Sakamaki, Takeharu Yamanaka

Surgical laparoscopy, endoscopy & percutaneous techniques 28 ( 2 ) 102 - 107 2018.4

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DOI： 10.1097/SLE.0000000000000520

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Evaluation of Optimal Lymph Node Dissection in Remnant Gastric Cancer Based on Initial Distal Gastrectomy Reviewed

Iguchi Kenta, Kunisaki Chikara, Sato Sho, Tanaka Yusaku, Miyamoto Hiroshi, Kosaka Takashi, Akiyama Hirotoshi, Endo Itaru, Rino Yasushi, Masuda Munetaka

ANTICANCER RESEARCH 38 ( 3 ) 1677 - 1683 2018.3

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DOI： 10.21873/anticanres.12401

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Risk Factors for Anastomotic Leakage of Esophagojejunostomy after Laparoscopy-Assisted Total Gastrectomy for Gastric Cancer Reviewed

Oshi Masanori, Kunisaki Chikara, Miyamoto Hiroshi, Kosaka Takashi, Akiyama Hirotoshi, Endo Itaru

DIGESTIVE SURGERY 35 ( 1 ) 28 - 34 2018

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DOI： 10.1159/000464357

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Multicenter phase II study of capecitabine plus cisplatin as first-line therapy for human epidermal growth factor receptor 2-negative advanced gastric cancer: Yokohama Clinical Oncology Group Study YCOG1107 Reviewed

Kei Sato, Chikara Kunisaki, Takashi Kosaka, Ryo Takagawa, Masazumi Takahashi, Yusuke Izumisawa, Hiroshi Miyamoto, Sho Sato, Yusaku Tanaka, Naotaka Yamaguchi, Jun Kimura, Hidetaka A. Ono, Hirochika Makino, Hirotoshi Akiyama, Itaru Endo

CANCER CHEMOTHERAPY AND PHARMACOLOGY 80 ( 5 ) 939 - 943 2017.11

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DOI： 10.1007/s00280-017-3430-6

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Is Routine Prophylactic Cholecystectomy Necessary During Gastrectomy for Gastric Cancer? Reply Reviewed

Jun Kimura, Chikara Kunisaki, Ryo Takagawa, Hirochika Makino, Michio Ueda, Mitsuyoshi Ota, Mari Oba, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

WORLD JOURNAL OF SURGERY 41 ( 10 ) 2643 - 2643 2017.10

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DOI： 10.1007/s00268-017-4045-0

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単孔式腹腔鏡下盲腸部分切除を施行し得た虫垂粘液腫の1例

前島沙織, 石部敦士, 高橋直行, 樅山将士, 小坂隆司, 秋山浩利, 遠藤格

神奈川医学会雑誌 44 ( 2 ) 195 - 195 2017.7

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Is Routine Prophylactic Cholecystectomy Necessary During Gastrectomy for Gastric Cancer? Reviewed

Jun Kimura, Chikara Kunisaki, Ryo Takagawa, Hirochika Makino, Michio Ueda, Mitsuyoshi Ota, Mari Oba, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

WORLD JOURNAL OF SURGERY 41 ( 4 ) 1047 - 1053 2017.4

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DOI： 10.1007/s00268-016-3831-4

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A Comparative Study of Intravenous Injection Form and Oral Jelly Form of Alendronate Sodium Hydrate for Bone Mineral Disorder after Gastrectomy Reviewed

Chikara Kunisaki, Yusaku Tanaka, Takashi Kosaka, Hiroshi Miyamoto, Sho Sato, Hideaki Suematsu, Norio Yukawa, Kei Sato, Yusuke Izumisawa, Hirotoshi Akiyama, Masataka Taguri, Takeharu Yamanaka, Itaru Endo

DIGESTION 95 ( 2 ) 162 - 171 2017

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DOI： 10.1159/000458755

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Surgical advantages of reduced-port laparoscopic gastrectomy in gastric cancer Reviewed

Kunisaki Chikara, Makino Hirochika, Yamaguchi Naotaka, Izumisawa Yusuke, Miyamato Hiroshi, Sato Kei, Hayashi Tsutomu, Sugano Nobuhiro, Suzuki Yoshihiro, Ota Mitsuyoshi, Tsuburaya Akira, Kimura Jun, Takagawa Ryo, Kosaka Takashi, Ono Hidetaka Andrew, Akiyama Hirotoshi, Endo Itaru

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 30 ( 12 ) 5520 - 5528 2016.12

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Surgical advantages of reduced-port laparoscopic gastrectomy in gastric cancer Reviewed

Kunisaki Chikara, Kosaka Takashi, Miyamoto Hiroshi, Tanaka Yusaku, Yukawa Norio, Ota Mitsuyoshi, Sato Kei, Izumisawa Yusuke, Akiyama Hirotoshi, Endo Itaru

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 31 110 2016.11

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Postoperative infectious complications-driven recurrence after radical resection for esophageal cancer Reviewed

Takashi Murakami, Chikara Kunisaki, Shinichi Hasegawa, Jun Kimura, Ryo Takagawa, Takashi Kosaka, Hidetaka A. Ono, Hirochika Makino, Hirotoshi Akiyama, Itaru Endo

Esophagus 13 ( 4 ) 343 2016.5

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DOI： 10.1007/s10388-016-0540-x

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Impact of Neoadjuvant Chemotherapy Among Patients with Pancreatic Fistula After Gastrectomy for Advanced Gastric Cancer Reviewed

Kosaka Takashi, Akiyama Hirotoshi, Makino Hirochika, Kimura Jun, Takagawa Ryo, Ono Hidetaka A, Kunisaki Chikara, Endo Itaru

ANTICANCER RESEARCH 36 ( 4 ) 1773 - 1777 2016.4

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The novel diagnostic method for colorectal cancer: Detection of methyl mercaptan from flatus. Reviewed

Atsushi Ishibe, Mitsuyoshi Ota, Hiroshi Tsuboi, Akemi Takeshita, Yusuke Suwa, Shinsuke Suzuki, Hirokazu Suwa, Masashi Momiyama, Jun Watanabe, Takashi Kosaka, Kazuteru Watanabe, Hirotoshi Akiyama, Yasushi Ichikawa, Chikara Kunisaki, Itaru Endo

JOURNAL OF CLINICAL ONCOLOGY 34 ( 4 ) 2016.2

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DOI： 10.1200/jco.2016.34.4_suppl.529

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Application of reduced-port laparoscopic total gastrectomy in gastric cancer preserving the pancreas and spleen Reviewed

Kunisaki Chikara, Makino Hirochika, Kimura Jun, Takagawa Ryo, Ota Mitsuyoshi, Kosaka Takashi, Akiyama Hirotoshi, Endo Itaru

GASTRIC CANCER 18 ( 4 ) 868 - 875 2015.10

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Imaging and Antitumoral Effect of a Cyclo-oxygenase 2-specific Replicative Adenovirus for Small Metastatic Gastric Cancer Lesions Reviewed

Takashi Kosaka, Julia Davydova, Hidetaka A. Ono, Hirotoshi Akiyama, Shu-Ichi Hirai, Shigeo Ohno, Fumitaka Takeshita, Kazunori Aoki, Takahiro Ochiya, Masato Yamamoto, Chikara Kunisaki, Itaru Endo

ANTICANCER RESEARCH 35 ( 10 ) 5201 - 5210 2015.10

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Exosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer Reviewed

Motohiko Tokuhisa, Yasushi Ichikawa, Nobuyoshi Kosaka, Takahiro Ochiya, Masakazu Yashiro, Kosei Hirakawa, Takashi Kosaka, Hirochika Makino, Hirotoshi Akiyama, Chikara Kunisaki, Itaru Endo

PLOS ONE 10 ( 7 ) e0130472 2015.7

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Impact of S-1 plus cisplatin neoadjuvant chemotherapy in scirrhous gastric cancer. Reviewed

Kunisaki Chikara, Makino Hirochika, Kimura Jun, Takagawa Ryo, Kanazawa Amane, Oshima Takashi, Ota Mitsuyoshi, Kosaka Takashi, Ono Hidetaka, Akiyama Hirotoshi, Endo Itaru

JOURNAL OF CLINICAL ONCOLOGY 33 ( 3 ) 2015.1

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Postoperative Surveillance and Prognostic Factors in Patients with Esophageal Cancer Reviewed

Chikara Kunisaki, Hirochika Makino, Jun Kimura, Mitsuyoshi Ota, Ryo Takagawa, Takashi Kosaka, Hidetaka A. Ono, Hirotoshi Akiyama, Itaru Endo

HEPATO-GASTROENTEROLOGY 61 ( 133 ) 1262 - 1273 2014.7

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DOI： 10.5754/hge14266

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Safety and antiemetic effect of palonosetron for chemoradiation therpy of esophageal cancer Reviewed

Yasushi Ichikawa, Ayumu Goto, Noritoshi Kobayashi, Motohiko Tokuhisa, Takashi Ishikawa, Hirochika Makin, Takashi Kosaka, Hlrotoshi Aklyama, Chikara Kunisaki, Shin Maeda, Itaru Endo

JOURNAL OF CLINICAL ONCOLOGY 32 ( 15 ) 2014.5

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DOI： 10.1200/jco.2014.32.15_suppl.e20695

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Preoperative S-1 and docetaxel combination chemotherapy in patients with locally advanced gastric cancer Reviewed

Kosaka Takashi, Akiyama Hirotoshi, Makino Hirochika, Takagawa Ryo, Kimura Jun, Ono Hidetaka, Kunisaki Chikara, Endo Itaru

CANCER CHEMOTHERAPY AND PHARMACOLOGY 73 ( 2 ) 281 - 285 2014.2

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Phase I study of biweekly docetaxel, cisplatin, and S-1 combination neoadjuvant chemotherapy for stage III gastric cancer. Reviewed

Kunisaki Chikara, Makino Hirochika, Kimura Jun, Oshima Takashi, Ota Mitsuyoshi, Takagawa Ryo, Kosaka Takashi, Akiyama Hirotoshi, Endo Itaru

JOURNAL OF CLINICAL ONCOLOGY 32 ( 3 ) 2014.1

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A case of locally advanced gastric cancer in which the patient underwent curative gastrectomy after treatment with systemic chemotherapy with bi-weekly s-1/docetaxel Reviewed

Wada T, Kunisaki C, Hasegawa S, Kaida S, Tamura S, Ono H, Oshima T, Fujii S, Kosaka T, Makino H, Akiyama H, Endo I

Gan to kagaku ryoho. Cancer & chemotherapy 40 1533 - 1536 2013.11

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A case of locally advanced gastric cancer in which the patient underwent curative gastrectomy after treatment with systemic chemotherapy with bi-weekly S-1/docetaxel

Tomoko Wada, Chikara Kunisaki, Shinichi Hasegawa, Shuhei Kaida, Shuzo Tamura, Hidetaka Ono, Takashi Oshima, Shoichi Fujii, Takashi Kosaka, Hirochika Makino, Hirotoshi Akiyama, Itaru Endo

Japanese Journal of Cancer and Chemotherapy 40 ( 11 ) 1533 - 1536 2013.11

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J00296&link_issn=&doc_id=20131120480020&doc_link_id=%2Fab8gtkrc%2F2013%2F004011%2F021%2F1533-1536%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fab8gtkrc%2F2013%2F004011%2F021%2F1533-1536%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Conditionally replicative adenoviral vectors for imaging the effect of chemotherapy on pancreatic cancer cells. Reviewed

Kimura J, Ono HA, Kosaka T, Nagashima Y, Hirai S, Ohno S, Aoki K, Julia D, Yamamoto M, Kunisaki C, Endo I

Cancer science 104 ( 8 ) 1083 - 1090 2013.8

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Factors Predictive of Recurrence after Surgery for Gastric Cancer Followed by Adjuvant S-1 Chemotherapy Reviewed

Wada Tomoko, Kunisaki Chikara, Hasegawa Shinichi, Takagawa Ryo, Momiyama Masashi, Kosaka Takashi, Makino Hirochika, Ono Hidetaka Andrew, Oshima Takashi, Akiyama Hirotoshi, Endo Itaru

ANTICANCER RESEARCH 33 ( 4 ) 1747 - 1751 2013.4

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Biweekly Docetaxel and S-1 Combination Chemotherapy as First-line Treatment for Elderly Patients with Advanced Gastric Cancer Reviewed

Kunisaki Chikara, Takahashi Masazumi, Ono Hidetaka A, Hasegawa Shinichi, Tsuchida Kazuhito, Oshima Takashi, Ota Mitsuyoshi, Fukushima Tadao, Tokuhisa Motohiko, Izumisawa Yusuice, Takagawa Ryo, Kimura Jun, Kosaka Takashi, Makino Hirochika, Akiyama Hirotoshi, Endo Itaru

ANTICANCER RESEARCH 33 ( 2 ) 697 - 704 2013.2

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Low-dose docetaxel and cisplatin combination chemotherapy for stage II/III gastric cancer showing resistance to S-1 adjuvant chemotherapy: a phase I study Reviewed

Kunisaki Chikara, Ono Hidetaka A, Hasegawa Shinichi, Oshima Takashi, Fujii Shoichi, Tokuhisa Motohiko, Izumisawa Yusuke, Takagawa Ryo, Kimura Jun, Kosaka Takashi, Makino Hirochika, Akiyama Hirotoshi, Endo Itaru

JOURNAL OF CHEMOTHERAPY 24 ( 6 ) 364 - 372 2012.12

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Use of inflammation-based prognostic score to predict survival in patients with advanced gastric cancer receiving biweekly docetaxel and S-1 combination chemotherapy Reviewed

Kunisaki Chikara, Takahashi Masazumi, Ono Hidetaka, Oshima Takashi, Fujii Shoichi, Kosaka Takashi, Makino Hirochika, Akiyama Hirotoshi, Endo Itaru

JOURNAL OF CLINICAL ONCOLOGY 30 ( 15 ) 2012.5

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Surgical outcomes of laparoscopy-assisted gastrectomy versus open gastrectomy for gastric cancer: a case-control study Reviewed

Chikara Kunisaki, Hirochika Makino, Takashi Kosaka, Takashi Oshima, Shoichi Fujii, Ryo Takagawa, Jun Kimura, Hidetaka A. Ono, Hirotoshi Akiyama, Masataka Taguri, Satoshi Morita, Itaru Endo

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 26 ( 3 ) 804 - 810 2012.3

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DOI： 10.1007/s00464-011-1956-y

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Inflammation-Based Prognostic Score Predicts Survival in Patients with Advanced Gastric Cancer Receiving Biweekly Docetaxel and S-1 Combination Chemotherapy Reviewed

Kunisaki Chikara, Takahashi Masazumi, Ono Hidetaka A, Oshima Takashi, Takagawa Ryo, Kimura Jun, Kosaka Takashi, Makino Hirochika, Akiyama Hirotoshi, Endo Itaru

ONCOLOGY 83 ( 4 ) 183 - 191 2012

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Significance of Thoracoscopy-Assisted Surgery with a Minithoracotomy and Hand-Assisted Laparoscopic Surgery for Esophageal Cancer: The Experience of a Single Surgeon Reviewed

Chikara Kunisaki, Takashi Kosaka, Hidetaka A. Ono, Takashi Oshima, Shoichi Fujii, Ryo Takagawa, Jun Kimura, Motohiko Tokuhisa, Yusuke Izumisawa, Hirochika Makino, Hirotoshi Akiyama, Itaru Endo

Journal of Gastrointestinal Surgery 15 ( 11 ) 1939 - 1951 2011.11

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DOI： 10.1007/s11605-011-1664-x

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Therapeutic Strategy for Esophageal Cancer Based on Solitary Lymph Node Metastasis Reviewed

Kunisaki Chikara, Makino Hrochika, Kimura Jun, Oshima Takashi, Fujii Shoichi, Takagawa Ryo, Kosaka Takashi, Ono Hidetaka, Akiyama Hirotoshi, Endo Itaru

HEPATO-GASTROENTEROLOGY 58 ( 110 ) 1561 - 1565 2011.9

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Phase II study of biweekly docetaxel and S-1 combination chemotherapy as first-line treatment for advanced gastric cancer Reviewed

Chikara Kunisaki, Masazumi Takahashi, Hirochika Makino, Takashi Oshima, Shoichi Fujii, Ryo Takagawa, Jun Kimura, Takashi Kosaka, Hidetaka A. Ono, Hirotoshi Akiyama, Kunio Kameda, Fumihiko Kito, Satoshi Morita, Itaru Endo

CANCER CHEMOTHERAPY AND PHARMACOLOGY 67 ( 6 ) 1363 - 1368 2011.6

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DOI： 10.1007/s00280-010-1433-7

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Application of the transorally inserted anvil (OrVilTM) after laparoscopy-assisted total gastrectomy Reviewed

Chikara Kunisaki, Hirochika Makino, Takashi Oshima, Shoichi Fujii •Jun Kimura, •, Ryo Takagawa, Takashi Kosaka, Hirotoshi Akiyama, Satoshi Morita, Itaru Endo

Surg Endosc 25 ( 4 ) 1300 - 1305 2011.4

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DOI： 10.1007/s00464-010-1367-5

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胃癌に対する腹腔鏡下胃切除術と開腹胃切除術-A Case-Control Study Invited

國崎主税, 小坂隆司, 長谷川慎一, 大島貴, 藤井正一, 高川亮, 木村準, 牧野洋知, 小野秀高, 秋山浩利, 田栗正隆, 森田智視, 遠藤格

癌の臨床 56 ( 12 ) 863 - 868 2010.12

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Effect of Obesity on Laparoscopy-Assisted Distal Gastrectomy Compared With Open Distal Gastrectomy for Gastric Cancer Reviewed

Makino Hirochika, Kunisaki Chikara, Izumisawa Yusuke, Tokuhisa Motohiko, Oshima Takashi, Nagano Yasuhiko, Fujii Shoichi, Kimura Jun, Takagawa Ryo, Kosaka Takashi, Ono Hidetaka A, Akiyama Hirotoshi, Endo Itaru

JOURNAL OF SURGICAL ONCOLOGY 102 ( 2 ) 141 - 147 2010.8

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Clinicopathological Features in N0 Oesophageal Cancer Patients Reviewed

Kunisaki Chikara, Makino Hrochika, Oshima Takashi, Fujii Shoichi, Takagawa Ryo, Kimura Jun, Kosaka Takashi, Ono Hidetaka A, Akiyama Hirotoshi, Endo Itaru

ANTICANCER RESEARCH 30 ( 7 ) 3063 - 3069 2010.7

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Indication for Hepatic Resection in the Treatment of Liver Metastasis from Gastric Cancer Reviewed

Makino Hirochika, Kunisaki Chikara, Izumisawa Yusuke, Tokuhisa Motohiko, Oshima Takashi, Nagano Yasuhiko, Fujii Shoichi, Kimura Jun, Takagawa Ryo, Kosaka Takashi, Ono Hidetaka A, Akiyama Hirotoshi, Tanaka Kuniya, Endo Itaru

ANTICANCER RESEARCH 30 ( 6 ) 2367 - 2376 2010.6

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Impact of lymph-node metastasis site in patients with thoracic escophageal cancer Reviewed

Chikara Kunisaki, Hirochika Makino, Jun Kimura, Takashi Oshima, Shoichi Fujii, Ryo Takagawa, Takashi Kosaka, Hidetaka A. Ono, Hirotoshi Akiyama

Jounal of Surgical Oncology 101 ( 1 ) 36 - 42 2010.1

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DOI： 10.1002/jso.21425

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A Pilot Study Comparing Jejunal Pouch and Jejunal Interposition Reconstruction after Proximal Gastrectomy Reviewed

Takagawa Ryo, Kunisaki Chikara, Kimura Jun, Makino Hirochika, Kosaka Takashi, Ono Hidetaka A, Akiyama Hirotoshi, Endo Itaru

DIGESTIVE SURGERY 27 ( 6 ) 502 - 508 2010

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Phase II Study of Weekly Paclitaxel as a Second-line Treatment for S-1-refractory Advanced Gastric Cancer Reviewed

Goro Matsuda, Chikara Kunisaki, Hirochika Makino, Michiko Fukahori, Jun Kimura, Tsutomu Sato, Takashi Oshima, Yasuhiko Nagano, Shoichi Fujii, Ryo Takagawa, Takashi Kosaka, Hidetaka A. Ono, Hirotoshi Akiyama, Yasushi Ichikawa

Anticancer Research 29 ( 7 ) 2863 - 2868 2009.7

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Prospective Randomized Controlled Trial Comparing the use of 3.5-mm and 4.8-mm Staples in Gastric Surgery Reviewed

Chikara Kunisaki, Hirochika Makino, Ryo Takagawa, Naoto Yamamoto, Yasuhiko Nagano, Shoichi Fujii, Takashi Kosaka, Hidetaka A. Ono, Hirotoshi Akiyama, Hiroshi Shimada

Hepato-gastroenterology 55 ( 86-87 ) 1943 - 1947 2008.9

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Therapeutic management of elderly patients with esophageal cancer Reviewed

Ryo Takagawa, Chikara Kunisaki, Hirochika Makino, Takashi Oshima, Yasuhiko Nagano, Syoichi Fujii, Takashi Kosaka, Hidetaka A. Ono, Hirotoshi Akiyama, Hiroshi Shimada

Esophagus 5 ( 3 ) 133 - 139 2008.9

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DOI： 10.1007/s10388-008-0159-7

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Phase I study of biweekly docetaxel and S-1 combination chemotherapy for advanced gastric cancer Reviewed

Chikara Kunisaki, Masazumi Takahashi, Yutaka Nagahori, Hirochika Makino, Ryo Takagawa, Tsutomu Sato, Takashi Oshima, Shoichi Fujii, Takashi Kosaka, Hidetaka A. Ono, Hirotoshi Akiyama, Hiroshi Shimada

ANTICANCER RESEARCH 28 ( 4C ) 2473 - 2478 2008.7

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Tumor diameter as a prognostic factor in patients with gastric cancer. Reviewed International journal

Chikara Kunisaki, Hirochika Makino, Ryo Takagawa, Takashi Oshima, Yasuhiko Nagano, Takashi Kosaka, Hidetaka A Ono, Yuichi Otsuka, Hirotoshi Akiyama, Yasushi Ichikawa, Hiroshi Shimada

Annals of surgical oncology 15 ( 7 ) 1959 - 67 2008.7

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DOI： 10.1245/s10434-008-9884-3

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Learning curve for laparoscopy-assisted distal gastrectomy with regional lymph node dissection for early gastric cancer Reviewed

Chikara Kunisaki, Hirochika Makino, Naoto Yamamoto, Tsutomu Sato, Takashi Oshima, Yasuhiko Nagano, Syoichi Fujii, Hirotoshi Akiyama, Yuichi Otsuka, Hidetaka A. Ono, Takashi Kosaka, Ryo Takagawa, Hiroshi Shimada

SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES 18 ( 3 ) 236 - 241 2008.6

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DOI： 10.1097/SLE.0b013e31816aa13f

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Surgical outcomes in esophageal cancer patients with tumor recurrence after curative esophagectomy. Reviewed

Kunisaki C, Makino H, Takagawa R, Yamamoto N, Nagano Y, Fujii S, Kosaka T, Ono HA, Otsuka Y, Akiyama H, Ichikawa Y, Shimada H

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 12 802 - 810 2008.5

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DOI： 10.1007/s11605-007-0385-7

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Effect of obesity on intraoperative bleeding volume in open gastrectomy with D2 lymph-node dissection for gastric cancer. Reviewed

Makino H, Kunisaki C, Akiyama H, Ono HA, Kosaka T, Takagawa R, Nagano Y, Fujii S, Shimada H

Patient safety in surgery 2 7 2008.4

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DOI： 10.1186/1754-9493-2-7

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Impact of palliative gastrectomy in patients with incurable advanced gastric cancer Reviewed

Kunisaki C, Makino H, Takagawa R, Oshima T, Nagano Y, Fujii S, Otsuka Y, Akiyama H, Ono HA, Kosaka T, Ichikawa Y, Shimada H

Anticancer Research 28 ( 2B ) 1309 - 1315 2008.3

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Predictive factors for anastomotic leakage in the neck after retrosternal reconstruction for esophageal cancer. Reviewed

Kunisaki C, Makino H, Akiyama H, Nomura M, Otsuka Y, Ono HA, Kosaka T, Kojima Y, Takagawa R, Shimada H

Hepato-gastroenterology 55 ( 81 ) 98 - 102 2008.1

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Impact of splenectomy in patients with gastric adenocarcinoma of the cardia Reviewed

Chikara Kunisaki, Hirochika Makino, Hirokazu Suwa, Tsutomu Sato, Takashi Oshima, Yasuhiko Nagano, Syoichi Fujii, Hirotoshi Akiyama, Masato Nomura, Yuichi Otsuka, Hidetaka A. Ono, Takashi Kosaka, Ryo Takagawa, Yasushi Ichikawa, Hiroshi Shimada

JOURNAL OF GASTROINTESTINAL SURGERY 11 ( 8 ) 1039 - 1044 2007.8

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腹腔鏡手術を施行した小腸憩室穿孔の一例

藤原大樹, 石部敦士, 鈴木紳祐, 佐藤渉, 小澤真由美, 小坂隆司, 秋山浩利, 加藤生真, 遠藤格

日本臨床外科学会雑誌 80 ( 10 ) 1949 - 1949 2019.10

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巨大小腸GISTの1切除例

小林侑華子, 小坂隆司, 藤田亮, 神田智希, 木下颯花, 布施匡啓, 鈴木紳祐, 小澤真由美, 石部敦士, 秋山浩利, 日比谷孝志, 三宅暁夫, 加藤生真, 山中正二, 大橋健一, 遠藤格

神奈川医学会雑誌 46 ( 1 ) 66 - 66 2019.1

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神奈川医学会雑誌 46 ( 2 ) 2019

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日本消化器外科学会雑誌(Web) 51 ( Supplement1 ) 2018

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「肺腺癌を合併した脾littoral cell angiomaの1例」

鳥谷建一郎, 國崎主税, 佐藤渉, 宮本洋, 小坂隆司, 湯川寛夫, 田中邦哉, 遠藤格

神奈川医学会雑誌 45 ( 2 ) 2018

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癌と化学療法 43 ( 7 ) 889 - 892 2016.7

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術中から始まる周術期感染対策 ERASプロトコール導入による腹腔鏡下結腸癌手術のSSI予防効果

石部敦士, 大田貢由, 鈴木紳祐, 諏訪雄亮, 諏訪宏和, 樅山将士, 渡邉純, 小坂隆司, 渡辺一輝, 秋山浩利, 市川靖史, 遠藤格

日本外科感染症学会雑誌 12 ( 5 ) 479 - 479 2015.11

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Imaging and antitumoral effect of a cyclo-oxygenase 2-specific replicative adenovirus for small metastatic gastric cancer lesions

Takashi Kosaka, Julia Davydova, Hidetaka A. Ono, Hirotoshi Akiyama, Shu-Ichi Hirai, Shigeo Ohno, Fumitaka Takeshita, Kazunori Aoki, Takahiro Ochiya, Masato Yamamoto, Chikara Kunisaki, Itaru Endo

Anticancer Research 35 ( 10 ) 5201 - 5210 2015.10

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A systematic review of laparoscopic total gastrectomy for gastric cancer

Chikara Kunisaki, Hirochika Makino, Ryo Takagawa, Jun Kimura, Mitsuyoshi Ota, Yasushi Ichikawa, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo

GASTRIC CANCER 18 ( 2 ) 218 - 226 2015.4

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DOI： 10.1007/s10120-015-0474-3

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Impact of S-1 plus Cisplatin Neoadjuvant Chemotherapy on Scirrhous Gastric Cancer

Chikara Kunisaki, Hirochika Makino, Jun Kimura, Ryo Takagawa, Amane Kanazawa, Mitsuyoshi Ota, Takashi Kosaka, Hidetaka A. Ono, Hirotoshi Akiyama, Itaru Endo

ONCOLOGY 88 ( 5 ) 281 - 288 2015

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DOI： 10.1159/000369497

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胃癌に対するReduced-port laparoscopic gastrectomy(RPG)の意義

國崎主税, 牧野洋知, 木村準, 高川亮, 林勉, 大島貴, 大田貢由, 円谷彰, 小坂隆司, 小野秀高, 秋山浩利, 遠藤格

日本内視鏡外科学会雑誌 19 ( 7 ) 568 - 568 2014.10

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胃癌に対するReduced-port laparoscopic distal gastrectomyの有用性

牧野洋知, 國崎主税, 木村準, 山口和哉, 金澤周, 大島貴, 大田貢由, 高川亮, 小坂隆司, 小野秀高, 秋山浩利, 遠藤格

日本外科系連合学会誌 39 ( 3 ) 431 - 431 2014.5

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Treatment Strategy for Liver Metastasis from Gastric Cancer

MAKINO HIROCHIKA, KUNISAKI CHIKARA, KIMURA JUN, TOKUHISA MOTOHIKO, TAKAGAWA RYO, KOSAKA TAKASHI, ONO HIDETAKA, TANAKA KUNIYA, AKIYAMA HIROTOSHI, ENDO ITARU

癌の臨床 59 ( 5 ) 491 - 500 2013.10

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Access Transformer OCTOTMを用いた胃癌に対するReduced-port Laparoscopic total gastrectomyの有用性

國崎主税, 小野秀高, 土田知史, 大島貴, 福島忠男, 高川亮, 木村準, 小坂隆司, 牧野洋知, 秋山浩利, 遠藤格

日本外科学会雑誌 114 ( 臨増2 ) 501 - 501 2013.3

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高齢者を含めた高リスク患者に対する化学療法の適応高齢者進行再発胃癌に対するbi-weekly DOC/S-1療法の有用性

國崎主税, 小野秀高, 土田知史, 大島貴, 福島忠男, 高川亮, 木村準, 小坂隆司, 牧野洋知, 秋山浩利, 遠藤格

日本胃癌学会総会記事 85回 186 - 186 2013.2

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安全確実な腹腔鏡補助下幽門側胃切除術を行うための工夫

牧野洋知, 杉山保幸, 國崎主税, 小野秀高, 大島貴, 福島忠男, 小坂隆司, 秋山浩利, 遠藤格

日本胃癌学会総会記事 85th 304 - 304 2013.2

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食道・胃接合部癌におけるOvilを用いた再建の有用性

小野秀高, 國崎主税, 土田知史, 大島貴, 福島忠男, 徳久元彦, 泉澤祐介, 高川亮, 木村潤, 小坂隆司, 牧野洋知, 秋山浩利, 遠藤格

日本胃癌学会総会記事 85th 320 - 320 2013.2

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Laparoscopy-assisted total gastrectomy reconstructed with OrVil

67 ( 12 ) 1402 - 1405 2012.11

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DOI： 10.11477/mf.1407104350

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J01539&link_issn=&doc_id=20121112480014&doc_link_id=10.11477%2Fmf.1407104350&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1407104350&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif
進行再発胃癌におけるGlasgow Prognostic Score(GPS)の予後規定因子としての意義

國崎主税, 小野秀高, 大島貴, 藤井正一, 福島忠男, 小坂隆司, 牧野洋知, 秋山浩利, 遠藤格

日本癌治療学会誌 47 ( 3 ) 1268 - 1268 2012.10

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胃癌に対するReduced-port Laparoscopic total gastrectomyの有用性

國崎主税, 小野秀高, 大島貴, 藤井正一, 福島忠男, 小坂隆司, 牧野洋知, 秋山浩利, 遠藤格

日本癌治療学会学術集会(CD-ROM) 50th ( 3 ) 1489 - 1489 2012.10

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進行胃癌患者における術後合併症予測因子の検討

小野秀高, 國崎主税, 長谷川慎一, 大島貴, 藤井正一, 木村準, 小坂隆司, 牧野洋知, 秋山浩利, 遠藤格

日本消化器外科学会総会 67回 1 - 1 2012.7

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胃癌治癒切除例におけるS-1術後補助化学療法後の再発リスクに関する検討

和田朋子, 國崎主税, 長谷川慎一, 小野秀高, 大島貴, 藤井正一, 牧野洋知, 小坂隆司, 秋山浩利, 遠藤格

日本消化器外科学会総会 67回 2 - 2 2012.7

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胃癌切除後の長期予後におけるBMIの影響

和田朋子, 小野秀高, 開田脩平, 小坂隆司, 長谷川慎一, 牧野洋和, 大島貴, 藤井正一, 秋山浩利, 國崎主税, 遠藤格

日本外科学会雑誌 113 ( 臨増2 ) 742 - 742 2012.3

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TS-1抵抗性再発胃癌に対するDocetaxel/Cisplatin少量分割併用化学療法(第I相試験)

佐野渉, 國崎主税, 小野秀高, 長谷川慎一, 大島貴, 藤井正一, 徳久元彦, 泉澤祐介, 高川亮, 木村準, 小坂隆司, 牧野洋知, 秋山浩利, 遠藤格

日本外科学会雑誌 113 ( 臨増2 ) 516 - 516 2012.3

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【外科医が行う胃癌化学療法】進行再発胃癌に対するbi-weekly DOC/S1併用化学療法

牧野洋知, 國崎主税, 高橋正純, 大島貴, 亀田久仁郎, 泉澤祐介, 徳久元彦, 木村準, 高川亮, 小坂隆司, 小野秀高, 秋山浩利, 森田智視, 遠藤格

癌の臨床 57 ( 1 ) 39 - 45 2011.10

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著者らが行ったbi-weekly DOC/S-1併用化学療法の第I 、第II相試験について報告した。その結果、第I相試験では全例切除不能の進行性胃癌で推奨用量(RD)決定までに21例を要し平均年齢は65.6歳、本レジメンは全105コース施行され、平均投与コースは4.8コースであった。毒性ではDOCの最大耐性(MTD)は45mg/m2投与となり、RDは40mg/m2と決定された。第II相対象症例は45例(年齢中央値68歳)、初発が42例、再発が3例で、組織型は分化型16例、未分化型29例、38例にリンパ節転移がみられ、12例に腹膜転移、8例に肝転移が認められた。45例に対して215コースの治療が施行され、投与コース中央値は4(2〜12)コースで、8例でDOCが35mg/m2に減量、更に4例で30mg/m2に減量された。治療中止の原因は病状進行が86.7%、手術移行が11.1%、患者の意思が2.2%であった。2コース終了時点での奏功率は57.8%(CR:1例・PR:25例)で、病勢コントロール率は84.5%であった。尚、2コース終了時までの毒性はいずれもコントロール可能で治療関連死は認めなかった。以上より、進行再発胃癌に対するbi-weekly DOC/S-1併用化学療法は有効かつ安全であると考えられた。

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手術・そこが知りたい!(胃癌の内視鏡下手術におけるNo.7/8a/9/11pの郭清) 腹腔鏡補助下胃切除術におけるリンパ節(No.7/8a/9/11p)の郭清の工夫

開田脩平, 小野秀高, 和田朋子, 田村周三, 大島貴, 藤井正一, 國崎主税, 小坂隆司, 秋山浩利, 遠藤格

日本臨床外科学会雑誌 72 ( 増刊 ) 403 - 403 2011.10

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胃癌に対するReduced-ports laparoscopic distal gastrectomyの有用性

國崎主税, 小野秀高, 田村周三, 長谷川慎一, 大島貴, 藤井正一, 徳久元彦, 泉澤祐介, 高川亮, 木村準, 小坂隆司, 牧野洋知, 秋山浩利, 遠藤格

日本癌治療学会誌 46 ( 2 ) 650 - 650 2011.9

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Her2陽性stage II,III胃癌ではS-1のadjuvant chemotherapyにかえてTrastuzumabを投与すべきか?

大島貴, 国崎主税, 小坂隆司, 長谷川慎一, 五代天偉, 藤井正一, 佐藤勉, 山田六平, 湯川寛夫, 利野靖, 益田宗孝, 今田敏夫

日本消化器病学会雑誌 108 ( 臨増総会 ) A290 - A290 2011.3

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胃癌に対するReduced-Port Laparoscopic Distal Gastrectomyの有用性

小野秀高, 國崎主税, 長谷川慎一, 大島貴, 杉田光隆, 藤井正一, 小坂隆司, 牧野洋知, 秋山浩利, 遠藤格

胃外科・術後障害研究会プログラム・抄録集 41st ( 45 ) 44 - 44 2011

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胃癌に対するReduced-port Laparoscopic Distal Gastrectomyの有用性

小野秀高, 國崎主税, 長谷川慎一, 大島貴, 杉田光隆, 藤井正一, 徳久元彦, 泉澤祐介, 高川亮, 木村準, 小坂隆司, 牧野洋知, 秋山浩利, 遠藤格

日本臨床外科学会雑誌 72 ( 増刊 ) 438 - 438 2011

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予後規定因子からみたN0食道癌の治療戦略

牧野洋知, 國崎主税, 小坂隆司, 泉澤祐介, 徳久元彦, 木村準, 高川亮, 小野秀高, 千島隆司, 大田貢由, 田中邦哉, 秋山浩利, 遠藤格

日本外科学会雑誌 112 2011

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胃癌腹腔鏡手術の長期成績・予後当院におけるcMP症例に対する腹腔鏡補助下幽門側胃切除術の短期・長期成績

小坂隆司, 國崎主税, 宮本洋, 浅野史雄, 長谷川慎一, 大島貴, 藤井正一, 牧野洋知, 秋山浩利, 遠藤格

日本臨床外科学会雑誌 71 ( 増刊 ) 355 - 355 2010.10

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外科医が行う胃癌化学療法進行再発胃癌に対するbi-weekly DOC/S 1併用化学療法

牧野洋知, 國崎主税, 高橋正純, 大島貴, 藤井正一, 亀田久仁郎, 泉澤祐介, 徳久元彦, 木村準, 高川亮, 小坂隆司, 小野秀高, 田中邦哉, 秋山浩利, 遠藤格

日本臨床外科学会雑誌 71 ( 増刊 ) 386 - 386 2010.10

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進行胃癌における各HER2測定法の臨床的有用性

大島貴, 國崎主税, 沼田正勝, 浅野史雄, 宮本洋, 稲垣大輔, 小坂隆司, 長谷川慎一, 五代天偉, 佐藤勉, 藤井正一, 利野靖, 益田宗孝, 今田敏夫

日本癌治療学会誌 45 ( 2 ) 513 - 513 2010.9

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進行再発胃癌に対するbi-weekly DOC/S1併用化学療法第II相臨床試験

國崎主税, 高橋正純, 牧野洋知, 佐藤勉, 大島貴, 藤井正一, 亀田久仁郎, 小坂隆司, 秋山浩利, 遠藤格

日本消化器外科学会総会 65回 289 - 289 2010.7

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進行再発胃癌に対するbi-weekly DOC/S1併用化学療法第II相臨床試験

國崎主税, 高橋正純, 牧野洋知, 徳久元彦, 泉澤祐介, 佐藤勉, 大島貴, 藤井正一, 亀田久仁郎, 高川亮, 木村準, 小坂隆司, 小野秀高, 秋山浩利, 遠藤格

日本消化器病学会雑誌 107 ( 臨増総会 ) A338 - A338 2010.3

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リンパ節転移陰性食道癌の予後規定因子からみた治療戦略

牧野洋知, 國崎主税, 小坂隆司, 泉澤祐介, 徳久元彦, 木村準, 高川亮, 小野秀高, 大田貢由, 千島隆司, 田中邦哉, 秋山浩利, 遠藤格

日本癌治療学会誌 45 ( 2 ) 2010

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早期胃癌に対する腹腔鏡補助下胃全摘術(LATG)の手技

國崎主税, 牧野洋知, 五代天偉, 深堀道子, 泉澤祐介, 徳久元彦, 大島貴, 永野靖彦, 藤井正一, 木村準, 高川亮, 小坂隆司, 小野秀高, 秋山浩利

日本臨床外科学会雑誌 70 ( 増刊 ) 700 - 700 2009.10

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胃癌における標準的腹腔鏡補助下幽門側胃切除術

牧野洋知, 泉澤祐介, 深堀道子, 五代天偉, 徳久元彦, 大島貴, 永野靖彦, 藤井正一, 木村準, 高川亮, 小坂隆司, 小野秀高, 秋山浩利, 國崎主税

日本臨床外科学会雑誌 70 ( 増刊 ) 338 - 338 2009.10

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TS1-failure進行・再発胃癌に対するドセタキセル/シスプラチン2ndライン療法の有用性

高川亮, 國崎主税, 牧野洋知, 徳久元彦, 泉澤祐介, 大島貴, 永野靖彦, 藤井正一, 木村準, 小坂隆司, 小野秀高, 秋山浩利, 市川靖史, 遠藤格

日本癌治療学会誌 44 ( 2 ) 511 - 511 2009.9

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Imaging and Gene Therapy of Gastric Cancer Tiny Metastatic Lesions with Cox2-Specific Replicative Adenovirus

Takashi Kosaka, Julia G. Davydova, Hidetaka A. Ono, Shuichi Hirai, Shigeo Ohno, Kazunori Aoki, Takahiro Ochiya, Masato Yamamoto, Chikara Kunisaki

MOLECULAR THERAPY 17 S184 - S184 2009.5

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進行再発胃癌に対するBi-weekly TS1/Docetaxel併用外来療法のphase I study

牧野洋知, 國崎主税, 高橋正純, 佐藤勉, 大島貴, 高川亮, 小坂隆司, 小野秀高, 秋山浩利

日本消化器病学会雑誌 106 ( 臨増総会 ) A178 - A178 2009.3

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Research Projects

Establishment of early phase dynamic imaging for therapeutic effect of chemotherapeutic agents

Grant number：20500395 2008 - 2010

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

KUNISAKI Chikara, KOSAKA Takashi

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Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

Conditionally Replicative Adenovirus(CRAd) is useful imaging tool for diagnosse of chemotherapy effect.

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