Updated on 2026/06/18

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写真a

 
Reiko Kunisaki
 
Organization
YCU Medical Center Inflammatory Bowel Disease Center Associate Professor
Title
Associate Professor
Homepage
http://square.umin.ac.jp/ycuibdc/index.html
Profile
2000年～横浜市立大学附属市民総合医療センターにてIBD内科診療に従事
2007年 炎症性腸疾患（IBD）センター 助教、2009年 准教授、2014年4月 内科担当部長
日本内科学会 認定内科医
日本消化器病学会 専門医，指導医
日本消化器内視鏡学会 専門医

特に専門としている研究分野：
・IBD合併妊娠
・小児IBDの病態と治療
・IBDの画像診断、病態解明、治療
・腸管ベーチェット病
External link

Degree

  • 博士（医学） ( 横浜市立大学 )

Research Interests

  • 潰瘍性大腸炎

  • 炎症性腸疾患

  • Behcet's disease

  • pediatrics

  • pregnancy

  • クローン病

Research Areas

  • Life Science / Gastroenterology

  • Life Science / General internal medicine  / inflammatory bowel disease

Research History

  • Inflammatory Bowel Disease Center   Director

    2014.4

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Professional Memberships

  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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  • JAPANESE SOCIETY OF GASTROENTEROLOGY

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  • JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY

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  • 日本炎症性腸疾患学会

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  • European Crohn’s and Colotis Organization (ECCO)

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Committee Memberships

  • 厚生労働科学研究難治性疾患克服研究事業 「腸管ベーチェット診療コンセンサスステートメント」   作成ワーキングメンバー  

       

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    Committee type：Government

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  • 厚生労働科学研究難治性疾患克服研究事業 「難治性炎症性腸管障害に関する調査研究」班   研究協力者  

       

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    Committee type：Government

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  • 日本消化器病学会 「炎症性腸疾患診療ガイドライン（第一版）」   作成委員  

       

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    Committee type：Academic society

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  • 日本小児栄養消化器肝臓病学会 「小児クローン病治療ガイドライン（第二版）」   作成委員  

       

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Papers

  • Development and validation of a novel intestinal ultrasound score for predicting endoscopic activity of ileocecal ulcers in intestinal Behçet's disease.

    Katsuki Yaguchi, Reiko Kunisaki, Sho Sato, Serina Haruyama, Kazuki Kurimura, Yoshinori Nakamori, Masafumi Nishio, Kenichiro Toritani, Rongrong Wu, Hideaki Kimura, Toshiaki Ebina, Kazushi Numata, Shin Maeda

    Journal of gastroenterology   61 ( 4 )   410 - 420   2026.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: No diagnostic criteria have been established to specifically evaluate the activity of intestinal lesions in Behçet's disease (BD). We aimed to identify intestinal ultrasound (IUS) parameters that were correlated with endoscopic ulcer activity, as well as develop and prospectively validate an IUS activity score for patients with intestinal BD. METHODS: Patients who underwent colonoscopy and IUS within 2 weeks during 2007-2019 were retrospectively included in the development phase. Correlations between corresponding endoscopic activity and seven IUS parameters [bowel wall thickness (BWT), vascularity, bowel wall stratification, white-plaque sign, mesenteric lymphadenopathy, extramural phlegmons, and fistulas] based on 73 examinations and were assessed. We created an IUS activity score with a multivariate logistic regression model and inter-observer assessment. This score was prospectively validated in a new cohort (2020-2024). RESULTS: Among seven IUS parameters, only BWT (p = 0.001) and vascularity (p = 0.004) were significantly associated with endoscopically active disease, with high inter-observer agreement confirmed (intraclass correlation = 0.98, weighted kappa = 0.83, respectively) in the development phase. The IUS score for ileocecal ulcers in intestinal BD (IUS-BD) was developed based on 2*BWT + 5*vascularity. With a cutoff ≥ 16 points, IUS-BD could detect active ileocecal ulcers (sensitivity 84.6%, specificity 91.2%, and accuracy 87.7%). In the validation cohort including 17 IUS examinations, the IUS-BD was significantly increased in the endoscopically active disease (p = 0.024), with high diagnostic performance (sensitivity 84.6%, specificity 100%). CONCLUSIONS: We developed and preliminarily validated a novel ultrasonographic score for intestinal BD to identify endoscopically active disease.

    DOI： 10.1007/s00535-025-02337-6

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  • Long-term remission of severe refractory scleritis associated with ulcerative colitis after proctocolectomy: a case report and literature review.

    Kazuki Kurimura, Reiko Kunisaki, Katsuki Yaguchi, Shunsuke Shibui, Misa Onishi, Serina Haruyama, Yoshinori Nakamori, Kenichiro Toritani, Hideaki Kimura, Shin Maeda

    Clinical journal of gastroenterology   19 ( 1 )   257 - 264   2026.2

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    Extraintestinal manifestations occur in up to 50% of patients with inflammatory bowel disease and can affect various organs, including the joints, skin, and eyes. Scleritis, one such extraintestinal manifestation, is associated with severe eye pain, vision impairment, and potential permanent vision loss. However, it is rare, and detailed descriptions of its characteristics and management are limited. We report the case of a 55-year-old man initially diagnosed with proctitis ulcerative colitis who simultaneously developed scleritis as the disease progressed to left-sided colitis. Treatment with 5-aminosalicylic acid, systemic steroids, and thiopurines failed to prevent a gradual decline in vision. Neither tacrolimus nor infliximab induced remission of ulcerative colitis or scleritis. Ultimately, total proctocolectomy was performed to treat refractory colitis. After surgery, the scleritis resolved immediately. Remission has persisted for over 10 years without recurrence, despite discontinuation of all medications (including ophthalmic solutions). This is the first documented case of severe, intractable scleritis resolving after proctocolectomy, suggesting an intestinal-ocular interaction in the pathogenesis of ulcerative colitis.

    DOI： 10.1007/s12328-025-02261-5

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  • Short- and Long-Term Outcomes of Endoscopic Resection for Serrated Lesions in Patients With Ulcerative Colitis: A Retrospective Exploratory Study. International journal

    Masafumi Nishio, Kingo Hirasawa, Reiko Kunisaki, Kimio Nozaki, Keita Morohashi, Tomoki Kanemura, Reo Atsusaka, Daisuke Azuma, Atsushi Sawada, Ryosuke Kobayashi, Chiko Sato, Tsuyoshi Ogashiwa, Hideaki Kimura, Sawako Chiba, Shin Maeda

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   38 ( 1 )   e70089   2026.1

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    OBJECTIVES: Endoscopic resection (ER) is well established for serrated lesions in patients with noninflammatory bowel disease; however, limited evidence supports its outcomes in patients with ulcerative colitis (UC). We evaluated the short- and long-term outcomes of ER for serrated polyps in patients with UC and assessed the risk of metachronous UC-associated neoplasia (UCAN). METHODS: We retrospectively analyzed 127 patients with UC who underwent ER for colorectal neoplasms between 2004 and 2024. Serrated polyps were categorized as sessile serrated lesions (SSLs), traditional serrated adenomas (TSAs), or unclassified serrated adenomas (USAs). Short-term outcomes, including en bloc and R0 resection rates, were compared between UCAN and sporadic neoplasia (SN). Long-term outcomes, including metachronous UCAN, were also analyzed. RESULTS: Among the 127 patients, 25 serrated lesions (13 SSLs, eight TSAs, and four USAs) were identified. The en bloc and R0 resection rates for serrated lesions were 96% and 92%, respectively, comparable to those for UCAN and SN. Over a median follow-up of 68 months, one patient with TSA developed invasive cancer 34 months post-ER, and two patients with USA developed UC-associated dysplasia. No metachronous UCAN was observed in the patients with SSL. The 5-year cumulative UCAN occurrence rate in the serrated lesion group was 18%, comparable to that in the UCAN group (29%) but significantly higher than that in the SN group (2%). CONCLUSIONS: Because the outcomes of ER were comparable to those of UCAN and SN, ER appears acceptable for serrated lesions in UC. However, TSA and USA may require stricter post-ER surveillance.

    DOI： 10.1111/den.70089

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  • Growth impairment in Japanese children with inflammatory bowel disease: A multicenter prospective cohort study. International journal

    Hirotaka Shimizu, Ryusuke Nambu, Nao Tachibana, Reiko Kunisaki, Takahiro Kudo, Sawako Kato, Tatsuki Mizuochi, Hideki Kumagai, Mikihiro Inoue, Naomi Iwata, Takeshi Saito, Takashi Ishige, Toshifumi Yodoshi, Atsuko Noguchi, Shigeo Nishimata, Takahiro Mochizuki, Shin-Ichiro Hagiwara, Mika Sasaki, Hitoshi Tajiri, Fumihiko Kakuta, Eitaro Hiejima, Itaru Iwama, Yuri Hirano, Toshiaki Shimizu, Katsuhiro Arai

    Journal of pediatric gastroenterology and nutrition   81 ( 5 )   1216 - 1226   2025.11

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    OBJECTIVES: To investigate the prevalence and characteristics of growth impairment (GI) in children with inflammatory bowel disease (IBD). METHODS: In this prospective observational study, 402 children with ulcerative colitis (UC, n = 257) and Crohn's disease (CD, n = 145) were enrolled from the Japanese Pediatric IBD Registry (2012-2020). GI was defined by Paris classification criteria. Longitudinal outcomes were assessed in children with ≥2 years of follow-up (n = 307). RESULTS: At diagnosis, the GI prevalence was comparable between children with UC and CD (6.2% vs. 8.3%, p = 0.54). However, children with UC diagnosed at 0-4 years demonstrated significantly higher GI rates (35.3%) than older children (p < 0.001). All children with CD experiencing GI had small intestinal lesions. Among those with GI at diagnosis, fewer children with UC (9%) recovered growth at a 2-year follow-up than those with CD (50%). Among children with normal growth at baseline, new-onset GI occurred in 23% of UC and 16% of CD cases. Of these, 31% recovered within 2 years, while persistent GI was observed in 16% of UC and 11% of CD cases. Prolonged corticosteroid use at 1 year was more frequent in UC (31% vs. 19%, p = 0.02) and was significantly associated with persistent GI. CONCLUSIONS: Distinct growth patterns exist in Japanese children with IBD. Children with UC diagnosed at 0-4 years are particularly vulnerable and may benefit from early, steroid-sparing treatment. The association between small intestinal lesions and GI in CD emphasizes the importance of small bowel evaluation. Age-specific, patient-centered growth monitoring is crucial to optimize long-term outcomes.

    DOI： 10.1002/jpn3.70202

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  • A Multicenter Observational Study for the Establishment of Novel Severity Criteria Including Endoscopic Evaluation for Intestinal Behçet's Disease

    Toshiro Fukui, Makoto Naganuma, Yohei Kirino, Reiko Kunisaki, Yohei Mikami, Nobuhiro Ueno, Junji Umeno, Shigeki Bamba, Makoto Ooi, Shuhei Hosomi, Takayuki Matsumoto, Katsuyoshi Matsuoka, Chikako Watanabe, Masakazu Nagahori, Motoi Uchino, Kenji Watanabe, Fumihito Hirai, Minoru Matsuura, Yoshiya Tanaka, Mitsuhiro Takeno, Tadakazu Hisamatsu

    Digestive Endoscopy   2025.9

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    ABSTRACT

    Objective

    This study aimed to establish a novel severity classification for intestinal Behçet's disease (BD) (SCIBD) and validate its criteria across multiple institutions.

    Methods

    Five parameters, including abdominal pain, tenderness, intestinal bleeding, serum C‐reactive protein (CRP) level, and endoscopic findings, were identified to assess the severity of intestinal BD. Disease severity was categorized into remission and mild, moderate, or severe disease based on the criteria of each factor. This study also evaluated the correlation among the SCIBD scale, serum biomarkers, former disease activity for intestinal BD (DAIBD), and treatment decisions.

    Results

    A total of 146 patients with intestinal BD and simple ulcers were retrospectively enrolled from 14 institutions between April and November 2022. As SCIBD severity increased, CRP and DAIBD levels significantly increased, whereas serum albumin levels decreased in the whole population. Similar correlations have been observed even in patients with intestinal BD. Antitumor necrosis factor‐alpha treatment was also significantly more common in severe cases (49.4%) than in moderate cases (20.8%; p = 0.001). However, the proportion of patients requiring corticosteroids was comparable between the moderate and severe disease groups (39.6% vs. 33.3%). In addition, no significant differences were observed in the frequency of corticosteroid treatment, anti‐TNF‐α treatment, or surgery among the four groups: quiescent, mild, moderate, and severe cases of DAIBD. SCIBD was changed after treatment with corticosteroids and TNF‐α according to improving clinical, biological, and endoscopic findings.

    Conclusions

    The severity assessment of intestinal BD using our novel criteria correlated with appropriate treatment decisions, prognosis prediction, and treatment responses.

    DOI： 10.1111/den.70041

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  • Week 2 remission with vedolizumab as a predictor of long-term remission in patients with ulcerative colitis: a multicenter, retrospective, observational study. International journal

    Taku Kobayashi, Tadakazu Hisamatsu, Satoshi Motoya, Toshimitsu Fujii, Reiko Kunisaki, Tomoyoshi Shibuya, Minoru Matsuura, Ken Takeuchi, Sakiko Hiraoka, Hiroshi Yasuda, Kaoru Yokoyama, Noritaka Takatsu, Atsuo Maemoto, Toshiyuki Tahara, Keiichi Tominaga, Masaaki Shimada, Nobuaki Kuno, Mary Cavaliere, Kaori Ishiguro, Jovelle L Fernandez, Toshifumi Hibi

    Intestinal research   2025.7

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    BACKGROUND/AIMS: Vedolizumab (VDZ), a gut-selective monoclonal antibody for ulcerative colitis (UC) treatment, has no established biomarkers or clinical features that predict long-term remission. Week 2 remission, a potential predictor of long-term remission, could inform maintenance treatment strategy. METHODS: This retrospective, observational chart review included patients with UC in Japan who initiated VDZ between December 2018 and February 2020. Outcome measures included 14- and 54-week remission rates in patients with week 2 and non-week 2 remission (remission by week 14), 54-week remission rates in patients with week 14 remission and primary nonresponse, and predictive factors of week 2 and week 54 remission (logistic regression). RESULTS: Overall, 332 patients with UC (176 biologic-naïve and 156 biologic-non-naïve) were included. Significantly more biologic-naïve than biologic-non-naïve patients achieved week 2 remission (36.9% vs. 28.2%; odds ratio [OR], 1.43; 95% confidence interval [CI], 1.05-1.94; P= 0.0224). Week 54 remission rates were significantly different between week 14 remission and primary nonresponse (both groups: P< 0.0001), and between week 2 and non-week 2 remission (all patients: OR, 2.41; 95% CI, 1.30-4.48; P= 0.0052; biologic-naïve patients: OR, 2.40; 95% CI, 1.10-5.24; P= 0.0280). Week 2 remission predictors were male sex, no anti-tumor necrosis factor alpha exposure, and normal/mild endoscopic findings. Week 54 remission was significantly associated with week 2 remission and no tacrolimus use. CONCLUSIONS: Week 2 remission with VDZ is a predictor of week 54 remission in patients with UC. Week 2 may be used as an evaluation point for UC treatment decisions. (Japanese Registry of Clinical Trials: jRCT-1080225363).

    DOI： 10.5217/ir.2025.00047

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  • 潰瘍性大腸炎に合併した大腸癌に対する局所切除術の妥当性の検討(Investigating the suitability of local resection for colorectal cancer complicated with UC)

    鳥谷 建一郎, 木村 英明, 今西 康太, 国崎 玲子, 西尾 匡史, 杉森 慎, 諏訪 雄亮, 小澤 真由美, 前田 慎, 遠藤 格

    日本消化器外科学会総会   80回   1643 - 1643   2025.7

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    Language：Japanese   Publisher：(一社)日本消化器外科学会  

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  • Current status of fertility rates and modes of delivery after restorative proctocolectomy with ileal pouch-anal anastomosis. International journal

    Hideaki Kimura, Kenichiro Toritani, Reiko Kunisaki, Koki Goto, Hirosuke Kuroki, Kenji Tatsumi, Kazutaka Koganei, Akira Sugita, Itaru Endo

    International journal of colorectal disease   40 ( 1 )   145 - 145   2025.6

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    PURPOSE: After restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA), fertility rates decline, and cesarean section (CS) has been the preferred mode of delivery. We aimed to assess the current trends and outcomes of pregnancy and delivery in patients who underwent RPC with IPAA. METHODS: This retrospective cohort study included 386 patients who underwent RPC with IPAA for UC between 2007 and 2023. Clinical data were collected through a chart review. Surgical techniques were mainly one- or modified two-stage RPC with stapled IPAA. The fallopian tube traction technique was applied to prevent adhesions. Fertility rates and delivery outcomes were also examined. RESULTS: Among 83 females of < 40 years of age, 18 attempted pregnancy after surgery. Natural conception was achieved in 14 cases (78%), and 2 cases were conceived through in vitro fertilization, resulting in a total of 16 pregnancies (89%). Among the 15 births, 11 (73%) were vaginal deliveries (VD), and 4 (27%) were CS. The reasons for CS included breech presentation (2 cases), prior CS (1 case), and a history of rectovaginal fistula (1 case). One VD case required episiotomy and the other experienced a perineal tear. However, there were no significant differences in postpartum defecation between the VD and CS groups. CONCLUSION: Fertility after RPC with IPAA appears to have improved compared to previous reports, possibly due to the prevention of fallopian tube adhesions. After a stapled IPAA, VD is a feasible option, and CS is not universally required solely because of the history of IPAA.

    DOI： 10.1007/s00384-025-04938-2

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  • The duration of prior anti-tumor necrosis factor agents is associated with the effectiveness of vedolizumab in patients with ulcerative colitis: a real-world multicenter retrospective study. International journal

    Taku Kobayashi, Tadakazu Hisamatsu, Satoshi Motoya, Minoru Matsuura, Toshimitsu Fujii, Reiko Kunisaki, Tomoyoshi Shibuya, Ken Takeuchi, Sakiko Hiraoka, Hiroshi Yasuda, Kaoru Yokoyama, Noritaka Takatsu, Atsuo Maemoto, Toshiyuki Tahara, Keiichi Tominaga, Masaaki Shimada, Nobuaki Kuno, Mary Cavaliere, Kaori Ishiguro, Jovelle L Fernandez, Toshifumi Hibi

    Intestinal research   2025.6

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    BACKGROUND/AIMS: Previous literature suggests that the response of patients with ulcerative colitis to vedolizumab may be affected by previous biologic therapy exposure. This real-world study evaluated vedolizumab treatment effectiveness in biologicnon- naïve patients. METHODS: This was a multicenter, retrospective, observational chart review of records from 16 hospitals in Japan (December 1, 2018, to February 29, 2020). Included patients who had ulcerative colitis, were aged ≥ 20 years, and received at least 1 dose of vedolizumab. Outcomes included clinical remission rates from weeks 2 to 54 according to prior biologic exposure status and factors associated with clinical remission up to week 54. RESULTS: A total of 370 eligible patients were included. Clinical remission rates were significantly higher in biologic-naïve (n=197) than in biologic-non-naïve (n=173) patients for weeks 2 to 54 of vedolizumab treatment. Higher clinical remission rates up to week 54 were significantly associated with lower disease severity (partial Mayo score ≤ 4, P= 0.001; albumin ≥ 3.0, P= 0.019) and the duration of prior anti-tumor necrosis factor α (anti-TNFα) therapy (P= 0.026). Patients with anti-TNFα therapy durations of < 3 months, 3 to < 12 months, and ≥ 12 months had clinical remission rates of 28.1%, 32.7%, and 60.0%, respectively (P= 0.001 across groups). CONCLUSIONS: The effectiveness of vedolizumab in biologic-non-naïve patients was significantly influenced by duration of prior anti-TNFα therapy. (Japanese Registry of Clinical Trials: jRCT-1080225363).

    DOI： 10.5217/ir.2024.00126

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  • Real-World Effectiveness and Safety of Vedolizumab in Patients ≥ 70 Versus < 70 Years With Ulcerative Colitis: Multicenter Retrospective Study. International journal

    Tadakazu Hisamatsu, Taku Kobayashi, Satoshi Motoya, Toshimitsu Fujii, Reiko Kunisaki, Tomoyoshi Shibuya, Minoru Matsuura, Sakiko Hiraoka, Ken Takeuchi, Hiroshi Yasuda, Kaoru Yokoyama, Noritaka Takatsu, Atsuo Maemoto, Toshiyuki Tahara, Keiichi Tominaga, Masaaki Shimada, Nobuaki Kuno, Jovelle L Fernandez, Lisa Hirose, Kaori Ishiguro, Mary Cavaliere, Toshifumi Hibi

    Journal of gastroenterology and hepatology   40 ( 6 )   1435 - 1445   2025.6

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    BACKGROUND AND AIM: Vedolizumab (VDZ) is often used in older patients with ulcerative colitis (UC) in clinical practice; however, real-world evidence is still limited, including in those with late-onset UC. METHODS: This post hoc analysis of a multicenter, retrospective, observational chart review, enrolling 370 patients with UC receiving VDZ between December 2018 and February 2020, compared effectiveness and safety of VDZ among patients ≥ 70 (n = 40) versus < 70 years (n = 330), and among patients ≥ 70 years with and without late-onset UC (age at disease onset: ≥ 70 [n = 13] versus < 70 years [n = 26]). RESULTS: There were no differences between patients ≥ 70 and < 70 years in clinical remission rates (week 6: 57.5% vs. 47.6%, p = 0.9174; week 14: 62.5% vs. 54.8%, p = 0.1317; week 54: 47.5% vs. 46.4%, p = 0.8149), primary nonresponse (10.0% vs. 15.5%, p = 0.6248), loss of response (12.5% vs. 9.4%, p = 0.5675), or overall safety. Among patients ≥ 70 years, the incidence of adverse drug reactions was numerically greater in those with concomitant corticosteroids than in those without. For older patients with and without late-onset UC, week 54 remission rates were 23.1% versus 57.7% (p = 0.0544); surgery was reported in 3/13 versus 2/26 patients and hospitalization in 5/13 versus 6/26 patients. One death was reported in patients with late-onset UC. CONCLUSIONS: VDZ effectiveness and safety were similar in patients ≥ 70 and < 70 years; VDZ may be a suitable treatment option for patients ≥ 70 years with UC. Patients with late-onset UC tended to have more frequent surgery/hospitalization and lower effectiveness than those without, possibly necessitating greater caution when using VDZ. TRIAL REGISTRATION: Japanese Registry of Clinical Trials registration number: jRCT-1080225363.

    DOI： 10.1111/jgh.16936

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  • Usefulness of Magnifying Endoscopy With Narrow-Band Imaging for Diagnosis of Ulcerative Colitis-Associated Neoplasia. International journal

    Masafumi Nishio, Kingo Hirasawa, Yusuke Saigusa, Zhao Shiqi, Tokomi Kenemura, Takanori Hama, Reo Atsusaka, Daisuke Azuma, Yuichiro Ozeki, Atsushi Sawada, Ryosuke Ikeda, Takehide Fukuchi, Ryosuke Kobayashi, Chiko Sato, Tsuyoshi Ogashiwa, Sawako Chiba, Yoshiaki Inayama, Reiko Kunisaki, Shin Maeda

    Journal of gastroenterology and hepatology   40 ( 4 )   900 - 906   2025.4

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    BACKGROUND AND AIM: Qualitative diagnosis of ulcerative colitis-associated neoplasia (UCAN) is crucial for surveillance colonoscopy in patients with ulcerative colitis (UC). Although the utility of magnifying endoscopy with narrow-band imaging (ME-NBI) in sporadic neoplasia diagnosis has been reported, its efficacy in UCAN remains unclear. This study aimed to evaluate the usefulness of ME-NBI for qualitative diagnosis of UCAN. METHODS: We generated 60 ME-NBI images (30 UCANs and 30 nonneoplasia lesions, including 10 polypoid and 20 nonpolypoid lesions) from patients with UC who underwent colonoscopy at our hospital between 2015 and 2023. Eleven endoscopists (seven experts and four trainees) independently assessed these images. Lesions were categorized into high- (≥ 80%), moderate- (50%-79%), and low- (< 50%) accuracy groups on the basis of the correct diagnostic rate. RESULTS: Overall sensitivity, specificity, and correct diagnostic rates were 66.5%, 79.0%, and 71.8%, respectively. Experts tended to exhibit higher specificity than trainees (83% vs. 70%). Polypoid lesions showed higher sensitivity (92% vs. 54%) and lower specificity (61% vs. 88%) than nonpolypoid lesions. Overall, the kappa value was 0.411. In UCAN, 37%, 37%, and 24% were classified into the high-, moderate-, and low-accuracy groups, respectively. All endoscopists assessed one case of UCAN in the low-accuracy group as a nonneoplastic vessel with a surface pattern. Only two nonneoplasias were identified as having nonneoplastic vessel and surface patterns by all endoscopists. CONCLUSIONS: This study demonstrated the usefulness of ME-NBI for qualitative diagnosis, along with its limitations. A unique endoscopic diagnostic algorithm for UCAN, incorporating ME-NBI and other modalities, is necessary.

    DOI： 10.1111/jgh.16877

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  • Factors affecting 1-year persistence with vedolizumab for ulcerative colitis: a multicenter, retrospective real-world study. International journal

    Taku Kobayashi, Tadakazu Hisamatsu, Satoshi Motoya, Toshimitsu Fujii, Reiko Kunisaki, Tomoyoshi Shibuya, Minoru Matsuura, Ken Takeuchi, Sakiko Hiraoka, Hiroshi Yasuda, Kaoru Yokoyama, Noritaka Takatsu, Atsuo Maemoto, Toshiyuki Tahara, Keiichi Tominaga, Masaaki Shimada, Nobuaki Kuno, Jovelle L Fernandez, Kaori Ishiguro, Mary Cavaliere, Hisato Deguchi, Toshifumi Hibi

    Intestinal research   2025.1

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    BACKGROUND/AIMS: The objectives of this real-world study were to determine 1-year persistence with vedolizumab in patients with ulcerative colitis and to evaluate factors contributing to loss of response. METHODS: In this multicenter, retrospective, observational chart review, patients with moderately to severely active ulcerative colitis who received ≥ 1 dose of vedolizumab in clinical practice at 16 tertiary hospitals in Japan (from December 2018 through February 2020) were enrolled. RESULTS: Persistence with vedolizumab was 64.5% (n = 370); the median follow-up time was 53.2 weeks. Discontinuation due to loss of response among initial clinical remitters was reported in 12.5% (35/281) of patients. Multivariate analysis showed that concomitant use of tacrolimus (odds ratio [OR], 2.76; 95% confidence interval [CI], 1.00-7.62; P= 0.050) and shorter disease duration (OR for median duration ≥ 7.8 years vs. < 7.8 years, 0.33; 95% CI, 0.13-0.82; P= 0.017) were associated with discontinuation due to loss of response. Loss of response was not associated with prior use of anti-tumor necrosis factor alpha therapy, age at the time of treatment, disease severity, or concomitant corticosteroids or immunomodulators. Of the 25 patients with disease duration < 1 year, 32.0% discontinued due to loss of response. CONCLUSIONS: Persistence with vedolizumab was consistent with previous reports. Use of tacrolimus and shorter disease duration were the main predictors of decreased persistence.

    DOI： 10.5217/ir.2024.00063

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  • Involvement of Mediterranean fever gene mutations in colchicine-responsive enterocolitis: a retrospective cohort study

    Hiroshi Nakase, Kohei Wagatsuma, Taku Kobayashi, Takayuki Matsumoto, Motohiro Esaki, Kenji Watanabe, Reiko Kunisaki, Teruyuki Takeda, Katsuhiro Arai, Takashi Ibuka, Dai Ishikawa, Yuichi Matsuno, Hirotake Sakuraba, Nobuhiro Ueno, Kaoru Yokoyama, Masayuki Saruta, Ryota Hokari, Junji Yokoyama, Shu Tamano, Masanori Nojima, Tadakazu Hisamatsu, Shusaku Yoshikawa, Sohachi Nanjo, Akira Andoh, Takeshi Kimura, Makoto Ooi, Ryosuke Kiyomori, Nobuo Aoyama, Fumihito Hirai, Atsushi Yamaushi, Masanao Nakamura, Fumikazu Koyama, Shuhei Hosomi, Kazuki Kakimoto, Satoshi Motoya, Ryosuke Sakemi, Hideo Suzuki, Tadashi Hosoya, Ken Takeuchi, Manabu Shiraki, Hideyuki Koide, Ichiro Takeuchi, Yosuke Furui, Kento Yoshida, Ayaka Minemura, Asami Matsumoto, Kentaro Oka

    eBioMedicine   110   105454 - 105454   2024.12

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    DOI： 10.1016/j.ebiom.2024.105454

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  • Massive bleeding and perforation due to post-colectomy pan-enteritis with a significant response to biologic in a patient with ulcerative colitis: a case report. International journal

    Kenichiro Toritani, Hideaki Kimura, Manabu Maebashi, Kazuki Kurimura, Serina Haruyama, Yoshinori Nakamori, Mao Matsubayashi, Reiko Kunisaki, Reiko Tanaka, Satoshi Fujii, Itaru Endo

    Surgical case reports   10 ( 1 )   201 - 201   2024.8

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    BACKGROUND: Post-colectomy pan-enteritis in ulcerative colitis (UC) is very rare, but it is often severe and fatal. We present a case of massive bleeding and perforation due to post-colectomy pan-enteritis, which showed a significant response to biologics in a UC patient. CASE PRESENTATION: A 30-year-old woman with a 5-month history of pancolitis UC underwent subtotal colectomy with ileostomy and mucosal fistula for refractory UC. She was diagnosed with small bowel obstruction on postoperative day (POD) 8 and bowel bleeding was observed on POD18. Reoperation was performed for bowel obstruction and bleeding on POD20. Intraoperatively, adhesive small bowel obstruction in the ileum and multiple erosions and ulcers with perforation were observed throughout the small bowel. We diagnosed post-colectomy pan-enteritis, and jejunostomy, lavage, adhesiolysis, and a simple closure of the perforated ileum were performed. High-dose steroid therapy for pan-enteritis was administered immediately after reoperation, and infliximab was administered because of worsening bleeding on day 3 after reoperation. Bleeding decreased one day after biologic administration and bleeding completely disappeared on day 10 after biologic administration. Specimens obtained from the terminal ileum at colectomy showed a normal ileum without inflammation and villus atrophy, while specimens from the perforated ileum showed congestion, villous atrophy, epithelial erosion, and mononuclear cell infiltration. No cryptitis, crypt distortion, or basal plasmacytosis (common characteristics in UC) were observed in either specimen. CONCLUSION: An early diagnosis and intervention are important for post-colectomy pan-enteritis, and infliximab may be effective. Post-colectomy pan-enteritis with a multiple ulcer phenotype has different histological characteristics from UC and may have a different pathogenesis.

    DOI： 10.1186/s40792-024-02003-8

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  • Intestinal ultrasound for intestinal Behçet disease reflects endoscopic activity and histopathological findings. International journal

    Katsuki Yaguchi, Reiko Kunisaki, Sho Sato, Kaori Hirai, Misato Izumi, Yoshimi Fukuno, Mami Tanaka, Mai Okazaki, Rongrong Wu, Yurika Nishikawa, Yusuke Matsune, Shunsuke Shibui, Yoshinori Nakamori, Masafumi Nishio, Mao Matsubayashi, Tsuyoshi Ogashiwa, Ayako Fujii, Kenichiro Toritani, Hideaki Kimura, Eita Kumagai, Yukiko Sasahara, Yoshiaki Inayama, Satoshi Fujii, Toshiaki Ebina, Kazushi Numata, Shin Maeda

    Intestinal research   2024.7

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    BACKGROUND/AIMS: Intestinal Behçet disease is typically associated with ileocecal punched-out ulcers and significant morbidity and mortality. Intestinal ultrasound is a noninvasive imaging technique for disease monitoring. However, no previous reports have compared intestinal ultrasound with endoscopic ulcer activity or histopathological findings for intestinal Behçet disease. We evaluated the usefulness of intestinal ultrasound for assessing the activity of ileocecal ulcers in intestinal Behçet disease. METHODS: We retrospectively compared intestinal ultrasound findings with 73 corresponding endoscopic images and 6 resected specimens. The intestinal ultrasound findings were assessed for 7 parameters (bowel wall thickness, vascularity [evaluated using the modified Limberg score with color Doppler], bowel wall stratification, white-plaque sign [strong hyperechogenic lines or spots], mesenteric lymphadenopathy, extramural phlegmons, and fistulas), and endoscopic ulcer activity was classified into active, healing, and scar stages. Histopathological findings were evaluated by consensus among experienced pathologists. RESULTS: Bowel wall thickness (P< 0.001), vascularity (P< 0.001), loss of bowel wall stratification (P= 0.015), and white-plague sign (P= 0.013) were significantly exacerbated in the endoscopic active ulcer stage. Receiver operating characteristic curve analysis revealed that a bowel wall thickness of > 5.5 mm (sensitivity 89.7%, specificity 85.3%) was potentially useful for detecting active lesions. When compared with histopathological findings, an increase in bowel wall thickness reflected the ulcer marginal ridge, and the white-plaque sign reflected the ulcer bottom. CONCLUSIONS: Intestinal ultrasound is useful for monitoring intestinal ulcer activity in intestinal Behçet disease.

    DOI： 10.5217/ir.2023.00129

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  • Prognosis of pediatric ulcerative colitis after infliximab failure: A multicenter registry-based cohort study. International journal

    Ryusuke Nambu, Takahiro Kudo, Nao Tachibana, Hirotaka Shimizu, Tatsuki Mizuochi, Sawako Kato, Mikihiro Inoue, Hideki Kumagai, Takashi Ishige, Reiko Kunisaki, Atsuko Noguchi, Toshifumi Yodoshi, Shin-Ichiro Hagiwara, Shigeo Nishimata, Fumihiko Kakuta, Takeshi Saito, Itaru Iwama, Yuri Hirano, Toshiaki Shimizu, Katsuhiro Arai

    Journal of gastroenterology and hepatology   2023.12

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    BACKGROUND AND AIM: Even with increasing numbers of biologic agents available for management of ulcerative colitis (UC), infliximab (IFX) retains an important place in treatment of pediatric patients with this disease. As few reports have addressed outcomes in pediatric UC patients who had to discontinue IFX, we examined clinical course and prognosis after IFX failure in pediatric UC. METHODS: A prospective cohort study of pertinent cases enrolled in the Japanese Pediatric Inflammatory Bowel Disease Registry between 2012 and 2020 was conducted to determine outcomes for pediatric UC patients who received IFX but required its discontinuation during follow-up (IFX failure). RESULTS: Of the 301 pediatric UC patients in the registry, 75 were treated with IFX; in 36 of these, IFX was discontinued during follow-up. Severity of UC at onset and absence of concomitant immunomodulator therapy were significant risk factors for IFX failure (P = 0.005 and P = 0.02, respectively). The cumulative colectomy rate after IFX failure was 41.3% at 1 year and 47.5% at 2 years. Colectomy was significantly more frequent when IFX was discontinued before June 1, 2018, than when IFX was discontinued later (P = 0.013). This difference likely involves availability of additional biologic agents for treatment of UC beginning in mid-2018 (P = 0.005). CONCLUSION: In pediatric UC patients, approximately 50% underwent colectomy during a 2-year interval following IFX failure. Prognosis after IFX failure appeared to improve with availability of new biologic agents and small-molecule drugs in mid-2018.

    DOI： 10.1111/jgh.16431

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  • 小児クローン病患者に対する診断後早期の治療内容 小児IBDレジストリ解析

    石毛 崇, 新井 勝大, 清水 泰岳, 岩間 達, 南部 隆亮, 国崎 玲子, 水落 建輝, 村越 孝次, 齋藤 武, 加藤 沢子, 工藤 孝広, 岩田 直美, 井上 幹大, 吉年 俊文, 萩原 真一郎, 戸板 成昭, 田尻 仁, 望月 貴博, 平野 友梨, 清水 俊明

    日本消化器病学会雑誌   120 ( 臨増大会 )   A781 - A781   2023.10

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  • Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis Reviewed

    Geert D’Haens, Marla Dubinsky, Taku Kobayashi, Peter M. Irving, Stefanie Howaldt, Juris Pokrotnieks, Kathryn Krueger, Janelle Laskowski, Xingyuan Li, Trevor Lissoos, Joe Milata, Nathan Morris, Vipin Arora, Catherine Milch, William Sandborn, Bruce E. Sands

    New England Journal of Medicine   388 ( 26 )   2444 - 2455   2023.6

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    Publishing type：Research paper (scientific journal)   Publisher：Massachusetts Medical Society  

    DOI： 10.1056/nejmoa2207940

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  • Utility of a rapid assay for prostaglandin E-major urinary metabolite as a biomarker in pediatric ulcerative colitis Reviewed

    Shin-ichiro Hagiwara, Naoki Abe, Kenji Hosoi, Tomoko Hara, Takashi Ishige, Hirotaka Shimizu, Tatsuki Mizuochi, Toshihiko Kakiuchi, Reiko Kunisaki, Ryo Matsuoka, Hiroki Kondou, Fumihiko Kakuta, Yoshiko Nakayama, Takeshi Kimura, Takatoshi Maeyama, Hitoshi Honma, Daishi Hirano, Masayuki Saruta, Tsutomu Yoshida, Isao Okayasu, Yuri Etani

    Scientific Reports   13 ( 1 )   2023.6

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    Abstract

    Prostaglandin E-major urinary metabolite (PGE-MUM) is a urinary biomarker reflecting ulcerative colitis (UC) activity. This prospective observational study aimed to evaluate the usefulness of PGE-MUM via rapid chemiluminescent enzyme immunoassay in detecting endoscopic remission (ER) and histologic remission (HR) in pediatric UC (6–16 years) in comparison with fecal calprotectin (FCP). ER and HR were defined as Mayo endoscopic score (MES) of 0 and Matts’ histological grades (Matts) of 1 or 2, respectively. A total of 104 UC and 39 functional gastrointestinal disorder (FGID) were analyzed. PGE-MUM levels were significantly higher in the UC group than in the FGID group (P &lt; 0.001). FCP levels were significantly elevated in the group without ER and HR than in the group with ER and HR (P &lt; 0.001 and P = 0.001), whereas PGE-MUM levels were significantly higher in the group without ER compared to the group with ER (P &lt; 0.001). No significant differences were noted in the AUCs for PGE-MUM and FCP in detecting ER and HR. Although PGE-MUM was inferior to FCP for the detection of HR, it might have the potential for application as a biomarker of endoscopic activity in pediatric UC owing to its noninvasive and rapid method.

    DOI： 10.1038/s41598-023-37145-6

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  • Correction: Characteristics of adult patients newly diagnosed with Crohn's disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn's disease in Japan (iCREST-CD).

    Katsuyoshi Matsuoka, Toshimitsu Fujii, Ryuichi Okamoto, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Kenji Watanabe, Hisashi Shiga, Noritaka Takatsu, Shigeki Bamba, Yohei Mikami, Takayuki Yamamoto, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Hiroshi Nakase, Atsuo Maemoto, Shinichiro Shinzaki, Yoko Murata, Shinichi Yoshigoe, Ayako Sasaki, Tsutomu Yajima, Tadakazu Hisamatsu

    Journal of gastroenterology   58 ( 6 )   602 - 603   2023.6

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  • Predictors of severe submucosal fibrosis during endoscopic submucosal dissection in patients with ulcerative colitis: Retrospective cohort study

    Masafumi Nishio, Kingo Hirasawa, Yusuke Saigusa, Reo Atsusaka, Daisuke Azuma, Yuichiro Ozeki, Atsushi Sawada, Ryosuke Ikeda, Takehide Fukuchi, Ryosuke Kobayashi, Chiko Sato, Tsuyoshi Ogashiwa, Yoshiaki Inayama, Reiko Kunisaki, Shin Maeda

    Digestive Endoscopy   2023.5

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/den.14570

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  • The effectiveness of endoscopic resection for colorectal neoplasms in ulcerative colitis: a multicenter registration study Reviewed

    Minami Hirai, Shunichi Yanai, Reiko Kunisaki, Masafumi Nishio, Kenji Watanabe, Toshiyuki Sato, Soichiro Ishihara, Hiroyuki Anzai, Takashi Hisabe, Shigeyoshi Yasukawa, Yasuharu Maeda, Kazumi Takishima, Akiko Ohno, Hisashi Shiga, Toshio Uraoka, Yuki Itoi, Haruhiko Ogata, Kaoru Takabayashi, Naohisa Yoshida, Yutaka Saito, Hiroyuki Takamaru, Keisuke Kawasaki, Motohiro Esaki, Nanae Tsuruoka, Tadakazu Hisamatsu, Takayuki Matsumoto

    Gastrointestinal Endoscopy   2023.5

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.gie.2023.05.058

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  • 小児クローン病患者に対する診断後早期の治療内容 小児IBDレジストリ解析

    石毛 崇, 新井 勝大, 清水 泰岳, 岩間 達, 南部 隆亮, 国崎 玲子, 水落 建輝, 村越 孝次, 齋藤 武, 加藤 沢子, 工藤 孝広, 岩田 直美, 井上 幹大, 吉年 俊文, 萩原 真一郎, 戸板 成昭, 田尻 仁, 望月 貴博, 角田 文彦, 清水 俊明

    日本小児栄養消化器肝臓学会雑誌   37 ( 1 )   45 - 45   2023.4

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  • 日本小児IBDレジストリにおける小児期発症IBD患者における成長障害の検討

    清水 泰岳, 南部 隆亮, 村越 孝次, 国崎 玲子, 工藤 孝広, 加藤 沢子, 水落 建輝, 熊谷 秀規, 井上 幹大, 後藤 友梨[平野], 新井 勝大, 清水 俊明

    日本小児栄養消化器肝臓学会雑誌   37 ( 1 )   46 - 46   2023.4

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  • Clinical outcome of ulcerative colitis with severe onset in children: a multicenter prospective cohort study

    Ryusuke Nambu, Katsuhiro Arai, Takahiro Kudo, Takatsugu Murakoshi, Reiko Kunisaki, Tatsuki Mizuochi, Sawako Kato, Hideki Kumagai, Mikihiro Inoue, Takashi Ishige, Takeshi Saito, Atsuko Noguchi, Toshifumi Yodoshi, Shin-Ichiro Hagiwara, Naomi Iwata, Shigeo Nishimata, Fumihiko Kakuta, Hitoshi Tajiri, Eitaro Hiejima, Nariaki Toita, Takahiro Mochizuki, Hirotaka Shimizu, Itaru Iwama, Yuri Hirano, Toshiaki Shimizu

    Journal of Gastroenterology   58 ( 5 )   472 - 480   2023.3

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1007/s00535-023-01972-1

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    Other Link： https://link.springer.com/article/10.1007/s00535-023-01972-1/fulltext.html

  • To Be in Remission or in Corticosteroid-free Remission: That Is the Question for Women With Inflammatory Bowel Disease at Conception. International journal

    Reiko Kunisaki, Aya Ikeda, Katsuki Yaguchi, Misa Onishi, Shunsuke Shibui, Daisuke Nishida, Akira Madarame, Kenichiro Toritani, Yoshinori Nakamori, Masafumi Nishio, Tsuyoshi Ogashiwa, Ayako Fujii, Hideaki Kimura, Ryoichi Suzuki, Shigeru Aoki, Shin Maeda

    Inflammatory bowel diseases   2023.3

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  • Diagnosis and Clinical Features of Perianal Lesions in Newly Diagnosed Crohn’s Disease: Subgroup Analysis from Inception Cohort Registry Study of Patients with Crohn’s Disease (iCREST-CD)

    Takayuki Yamamoto, Hiroshi Nakase, Kenji Watanabe, Shinichiro Shinzaki, Noritaka Takatsu, Toshimitsu Fujii, Ryuichi Okamoto, Katsuyoshi Matsuoka, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Hisashi Shiga, Shigeki Bamba, Yohei Mikami, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Atsuo Maemoto, Yoko Murata, Shinichi Yoshigoe, Shinya Nagasaka, Tsutomu Yajima, Tadakazu Hisamatsu, Masakazu Nagahori, Tatsu Yukawa, Daisuke Saito, Mikio Kawai, Atsushi Masamune, Mitsuo Nagasaka, Tomoe Kazama

    Journal of Crohn's and Colitis   2023.3

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    Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    Background and Aims

    Perianal lesion is a refractory phenotype of Crohn’s disease [CD] with significantly diminished quality of life. We evaluated the clinical characteristics of perianal lesions in newly diagnosed CD patients and the impact of perianal lesions on the quality of life in Japanese patients with CD.

    Methods

    Patients newly diagnosed with CD after June 2016 were included between December 2018 and June 2020 from the Inception Cohort Registry Study of Patients with CD [iCREST-CD].

    Results

    Perianal lesions were present in 324 [48.2%] of 672 patients with newly diagnosed CD; 71.9% [233/324] were male. The prevalence of perianal lesions was higher in patients aged &amp;lt;40 years vs ≥40 years, and it decreased with age. Perianal fistula [59.9%] and abscess [30.6%] were the most common perianal lesions. In multivariate analyses, male sex, age &amp;lt;40 years and ileocolonic disease location were significantly associated with a high prevalence of perianal lesions, whereas stricturing behaviour and alcohol intake were associated with low prevalence. Fatigue was more frequent [33.3% vs 21.6%] while work productivity and activity impairment-work time missed [36.3% vs 29.5%] and activity impairment [51.9% vs 41.1%] were numerically higher in patients with than those without perianal lesions.

    Conclusions

    At the time of CD diagnosis, approximately half of the patients had perianal lesions; perianal abscesses and perianal fistulas were the most common. Young age, male sex, disease location and behaviour were significantly associated with the presence of perianal lesions. The presence of perianal lesion was associated with fatigue and impairment of daily activities.

    Clinical trials registry

    University Hospital Medical Information Network Clinical Trials Registry System [UMIN-CTR, UMIN000032237].

    DOI： 10.1093/ecco-jcc/jjad038

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  • Expert consensus on vaccination in patients with inflammatory bowel disease in Japan.

    Takashi Ishige, Toshiaki Shimizu, Kenji Watanabe, Katsuhiro Arai, Koichi Kamei, Takahiro Kudo, Reiko Kunisaki, Daisuke Tokuhara, Makoto Naganuma, Tatsuki Mizuochi, Atsuko Murashima, Yuta Inoki, Naomi Iwata, Itaru Iwama, Sachi Koinuma, Hirotaka Shimizu, Keisuke Jimbo, Yugo Takaki, Shohei Takahashi, Yuki Cho, Ryusuke Nambu, Daisuke Nishida, Shin-Ichiro Hagiwara, Norikatsu Hikita, Hiroki Fujikawa, Kenji Hosoi, Shuhei Hosomi, Yohei Mikami, Jun Miyoshi, Ryusuke Yagi, Yoko Yokoyama, Tadakazu Hisamatsu

    Journal of gastroenterology   58 ( 2 )   135 - 157   2023.2

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    Immunosuppressive therapies can affect the immune response to or safety of vaccination in patients with inflammatory bowel disease (IBD). The appropriateness of vaccination should be assessed prior to the initiation of IBD treatment because patients with IBD frequently undergo continuous treatment with immunosuppressive drugs. This consensus was developed to support the decision-making process regarding appropriate vaccination for pediatric and adult patients with IBD and physicians by providing critical information according to the published literature and expert consensus about vaccine-preventable diseases (VPDs) [excluding cervical cancer and coronavirus disease 2019 (COVID-19)] in Japan. This consensus includes 19 important clinical questions (CQs) on the following 4 topics: VPDs (6 CQs), live attenuated vaccines (2 CQs), inactivated vaccines (6 CQs), and vaccination for pregnancy, childbirth, and breastfeeding (5 CQs). These topics and CQs were selected under unified consensus by the members of a committee on intractable diseases with support by a Health and Labour Sciences Research Grant. Physicians should provide necessary information on VPDs to their patients with IBD and carefully manage these patients' IBD if various risk factors for the development or worsening of VPDs are present. This consensus will facilitate informed and shared decision-making in daily IBD clinical practice.

    DOI： 10.1007/s00535-022-01953-w

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  • P183 Development of a new simple ultrasound activity score for intestinal Behçet's Disease

    K Yaguchi, R Kunisaki, S Sato, M Izumi, Y Fukuno, T Ebina, Y Matsune, T Hama, M Onishi, K Kobayashi, S Shibui, K Toritani, D Nishida, M Matsubayashi, Y Nakamori, M Nishio, S Umezawa, T Ogashiwa, T Sasaki, A Fujii, H Kimura, K Numata, S Maeda

    Journal of Crohn's and Colitis   17 ( Supplement_1 )   i336 - i336   2023.1

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    Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    Background

    Intestinal Behçet's disease (BD) is a relapsing-remitting disease typically associated with punched-out ulcers in the ileocecal region. Optimal monitoring of disease activity is necessary; however, ileocolonoscopy cannot be performed on a regular basis as it is invasive, resource-intensive and causes considerable patient discomfort. Furthermore, there are risks of intestinal bleeding and perforation caused by pretreatment laxatives and air insufflation during the examination. Hence, other follow-up examinations are required. Intestinal ultrasonography (IUS) is a minimally invasive imaging method, but there are no previous reports of comparisons between IUS and endoscopy for intestinal BD. This study aimed to evaluate the usefulness of IUS in assessing the activity of ileocecal ulcers in intestinal BD.

    Methods

    This retrospective single-centre study included patients with intestinal BD who underwent colonoscopy and IUS within 2 weeks, from 2007 to 2020. Correlations between the corresponding endoscopic activity using the Sakita–Miwa classification and six IUS variables (bowel wall thickness [BWT], vascularity, bowel wall stratification, intramural and extramural abscesses, fistulas and mesenteric lymphadenopathy) were assessed and used to select the variables that should be included in the new simple score. IUS findings were also compared with biomarker (C-reactive protein [CRP]) concentrations and clinical severity indices (Crohn’s disease activity index and disease activity index for intestinal BD [DAIBD]).

    Results

    Seventy-nine IUS examinations from 53 patients were included. Univariate analysis revealed that CRP and DAIBD and the IUS findings BWT, vascularity and bowel wall stratification and intramural and extramural abscesses differed significantly according to endoscopic ulcer activity. Multivariate analysis using a logistic regression model revealed that only BWT and vascularity were statistically different; therefore, a new simple score ([2*BWT] + [5*vascularity]) was constructed. Receiver operating characteristic curve analysis revealed an area under the curve of 0.91 for detecting endoscopic activity, which was superior to those of CRP (0.80; P=0.069), Crohn’s disease activity index (0.69; P=0.002) and DAIBD (0.67; P&amp;lt;0.001).

    Conclusion

    A new simple ultrasound activity index for intestinal BD comprising BWT and vascularity was constructed and correlated well with endoscopic disease activity. This is the first report describing the usefulness of IUS for intestinal BD, and we believe the findings will have many implications in clinical practice.

    DOI： 10.1093/ecco-jcc/jjac190.0313

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  • Appropriate Preconception Corticosteroid-Free Remission Period in Pregnant Women With Ulcerative Colitis. International journal

    Aya Ikeda, Reiko Kunisaki, Shigeru Aoki, Katsuki Yaguchi, Akira Madarame, Masafumi Nishio, Tsuyoshi Ogashiwa, Yoshinori Nakamori, Hideaki Kimura, Ryoichi Suzuki, Yusuke Saigusa, Shin Maeda

    Inflammatory bowel diseases   2023.1

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    BACKGROUND: In women with inflammatory bowel disease, at least 3 months of preconception corticosteroid-free remission (CFREM) is recommended by experts in current consensus statements. However, data are lacking on the appropriate preconception remission period. We investigated the appropriate preconception CFREM period in women with ulcerative colitis to reduce maternal disease activity and adverse pregnancy outcomes (ie, preterm birth, low birth weight, and small for gestational age). METHODS: We retrospectively examined 141 pregnancies in women with ulcerative colitis at 2 institutions. We categorized the patients into 3 subgroups by their preconception CFREM period (≥3 months, >0 to <3 months, and non-CFREM). We also investigated disease activity during pregnancy and postpartum and adverse pregnancy outcomes in each group. RESULTS: During pregnancy, the rate of active disease was significantly lower in the ≥3 months and >0 to <3 months CFREM groups compared with that in the non-CFREM group (P < .001 and P = .0257, respectively). Postpartum, the rate of active disease was significantly lower in the ≥3 months CFREM group compared with that in the non-CFREM group (P = .0087). The preconception CFREM period of ≥3 months was an independent inhibitory factor for active disease during pregnancy and postpartum (adjusted odds ratio, 0.15; P = .0035; and adjusted odds ratio, 0.33; P = .027, respectively). Adverse pregnancy outcomes were less common in the >3 months CFREM group compared with those in the other groups, but this difference was not significant. CONCLUSIONS: A preconception CFREM period of more than 3 months may be appropriate for better maternal and adverse pregnancy outcomes, as recommended in consensus statements.

    DOI： 10.1093/ibd/izac270

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  • Endoscopic resection is feasible for high-grade dysplasia in patients with ulcerative colitis. International journal

    Masafumi Nishio, Kingo Hirasawa, Sawako Chiba, Yuichiro Ozeki, Atsushi Sawada, Ryosuke Ikeda, Takehide Fukuchi, Ryosuke Kobayashi, Chiko Sato, Yoshiaki Inayama, Reiko Kunisaki, Shin Maeda

    Scandinavian journal of gastroenterology   58 ( 1 )   101 - 106   2023.1

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    BACKGROUND: Endoscopic resection (ER) is feasible for treating well-circumscribed dysplasia in patients with ulcerative colitis (UC). However, long-term prognosis of ER for high-grade dysplasia (HGD) in patients with UC remains unclear. We aimed to evaluate the long-term prognoses of ER for HGD compared with low-grade dysplasia (LGD) and verify the feasibility of ER and follow-up with surveillance colonoscopy for HGD. METHODS: An observational, single-center retrospective study included 38 and 22 patients with LGD and HGD who were followed-up with surveillance colonoscopy after ER. We evaluated the cumulative incidence rate of metachronous HGD or colorectal cancer (CRC) and identified the characteristics of metachronous dysplasia. RESULTS: The median follow-up period was 56 months, and surveillance colonoscopies were performed 3.6 times (mean). The 5-year cumulative incidence rate of HGD/CRC was relatively high in HGD (24.6%) than in LGD (13.7%), but the difference was not significant (p = .16). In HGD cases, six metachronous dysplasia lesions (two LGD and four HGD) were detected 11.6-40.5 months after ER. However, these patients did not progress to CRC. All metachronous lesions were well-circumscribed and with no invisible dysplasia surrounding them; they were 'endoscopically resectable' lesions. Two of the four metachronous HGD lesions were treated endoscopically and two, by colectomy. No synchronous HGD or CRC was detected in the colectomy specimens. CONCLUSIONS: Our results suggest that ER and follow-up with surveillance colonoscopy is feasible in patients with HGD when histological complete resection is achieved.

    DOI： 10.1080/00365521.2022.2107878

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  • Serrated polyps in patients with ulcerative colitis: Unique clinicopathological and biological characteristics. International journal

    Masafumi Nishio, Reiko Kunisaki, Wataru Shibata, Yoichi Ajioka, Kingo Hirasawa, Akiko Takase, Sawako Chiba, Yoshiaki Inayama, Wataru Ueda, Kiyotaka Okawa, Haruka Otake, Tsuyoshi Ogashiwa, Hiroto Kinoshita, Yusuke Saigusa, Hideaki Kimura, Jun Kato, Shin Maeda

    PloS one   18 ( 2 )   e0282204   2023

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    BACKGROUND: Serrated polyps have recently been reported in patients with ulcerative colitis (UC); however, their prevalence and detailed characteristics remain unclear. METHODS: The prevalence and clinicopathological and biological characteristics of serrated polyps in patients with UC were retrospectively examined in a single tertiary inflammatory bowel disease center in Japan from 2000 to 2020. RESULTS: Among 2035 patients with UC who underwent total colonoscopy, 252 neoplasms, including 36 serrated polyps (26 in colitis-affected segments, 10 in colitis-unaffected segments), were identified in 187 patients with UC. The proportion of serrated polyps was 1.8% (36/2035). Serrated polyps in colitis-affected segments were common with extensive colitis (88%), history of persistent active colitis (58%), and long UC duration (12.1 years). Serrated polyps in colitis-affected segments were more common in men (88%). Of the 26 serrated polyps in colitis-affected segments, 15, 6, and 5 were categorized as sessile serrated lesion-like dysplasia, traditional serrated adenoma-like dysplasia, and serrated dysplasia not otherwise specified, respectively. Sessile serrated lesion-like dysplasia was common in the proximal colon (67%) and with BRAF mutation (62%), whereas traditional serrated adenoma-like dysplasia and serrated dysplasia not otherwise specified were common in the distal colon (100% and 80%, respectively) and with KRAS mutations (100% and 75%, respectively). CONCLUSIONS: Serrated polyps comprised 14% of the neoplasias in patients with UC. Serrated polyps in colitis-affected segments were common in men with extensive and longstanding colitis, suggesting chronic inflammation in the development of serrated polyps in patients with UC.

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  • Fulminant Amebic Enteritis in the Perinatal Period: A Case Report.

    Daisuke Azuma, Reiko Kunisaki, Tatsu Yukawa, Katsuki Yaguchi, Mamoru Watanabe, Shunsuke Shibui, Yoshinori Nakamori, Junya Toyoda, Mikiko Tanabe, Koki Maeda, Yoshiaki Inayama, Hideaki Kimura, Shin Maeda

    Internal medicine (Tokyo, Japan)   2022.12

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    Pregnancy is a known risk factor for amebic enteritis, which develops into potentially fatal fulminant amebic enteritis in some cases. We describe a case of a 27-year-old non-immunosuppressed pregnant woman with fulminant amebic enteritis complicated with cytomegalovirus enteritis. She improved with intensive care and intravenous metronidazole and ganciclovir but eventually required subtotal colectomy for intestinal stenosis. It is difficult to diagnose amebic enteritis, especially in a non-endemic area. Amebic enteritis must be considered as a differential diagnosis for refractory diarrhea with bloody stools in women in the perinatal period, even those without immunosuppression.

    DOI： 10.2169/internalmedicine.0839-22

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  • Characteristics of adult patients newly diagnosed with Crohn's disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn's disease in Japan (iCREST-CD).

    Katsuyoshi Matsuoka, Toshimitsu Fujii, Ryuichi Okamoto, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Kenji Watanabe, Hisashi Shiga, Noritaka Takatsu, Shigeki Bamba, Yohei Mikami, Takayuki Yamamoto, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Hiroshi Nakase, Atsuo Maemoto, Shinichiro Shinzaki, Yoko Murata, Shinichi Yoshigoe, Ayako Sasaki, Tsutomu Yajima, Tadakazu Hisamatsu

    Journal of gastroenterology   57 ( 11 )   867 - 878   2022.8

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    BACKGROUND: The Inception Cohort Registry Study of Patients with Crohn's Disease aimed to clarify clinical characteristics and disease course of newly diagnosed Crohn's disease patients in Japan throughout a 4-year period. Results from an interim analysis of the largest nation-wide registry study that covers approximately 1% of Crohn's disease patient population in Japan are reported. METHODS: This prospective, observational registry study was conducted at 19 tertiary centers in Japan. Patients newly diagnosed with Crohn's disease after June 2016 (age ≥ 16 years at informed consent) were enrolled between December 17, 2018 and June 30, 2020. Patient demographics, diagnostic procedures and categories, disease location and lesion behavior (Montreal classification) at the time of diagnosis were recorded. RESULTS: Of 673 patients enrolled, 672 (99.9%) were analyzed (458: men, 214: women), male-to-female ratio: 2.1, median age at diagnosis 25 (range 13-86) years; peak age of disease diagnosis: 20-24 years. Most common disease location was L3 (ileocolonic; 60.1%). Non-stricturing, non-penetrating (B1) disease was most common behavior (62.8%); 48.9% reported perianal lesions. Notably, age-wise analysis revealed disease phenotypes varied between patients aged < 40 and ≥ 40 years in terms of male-to-female ratio (2.5/1.3)/disease location (L3: 66.3%/37.0%)/disease behavior (B1: 66.4%/50.0%)/perianal lesion: (55.7%/20.5%) at Crohn's disease diagnosis, respectively. CONCLUSIONS: Interim analysis of this nation-wide Inception Cohort Registry Study of Patients with Crohn's Disease revealed the demographics and disease characteristics of newly diagnosed Crohn's disease patients in Japan and demonstrated that disease phenotype varied between patients aged < 40 and ≥ 40 years, serving as important information for management of individual patients.

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  • Magnifying endoscopy is useful for tumor border diagnosis in ulcerative colitis patients. International journal

    Masafumi Nishio, Kingo Hirasawa, Yuichiro Ozeki, Atsushi Sawada, Ryosuke Ikeda, Takehide Fukuchi, Ryosuke Kobayashi, Chiko Sato, Tsuyoshi Ogashiwa, Yoshiaki Inayama, Reiko Kunisaki, Shin Maeda

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver   54 ( 6 )   812 - 818   2022.6

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    BACKGROUND AND AIMS: Endoscopic resection (ER) is feasible for well-circumscribed tumors in patients with ulcerative colitis (UC); however, the specific manner for diagnosis of the tumor border is unclear. We evaluated the efficacy of magnifying endoscopy (ME) for the diagnosis of tumor borders in UC. METHODS: We analyzed endoscopically or surgically resected tumors in UC patients in whom both chromoendoscopy (CE) and ME were performed, retrospectively. We classified the tumors based on tumor border visibility and evaluated tumor's characteristics and ER outcomes. RESULTS: We examined 100 tumors from 76 UC patients (66 distinct and 34 indistinct on CE). In 22 (65%) indistinct tumors on CE, ME improved the tumor border visibility. Compared with distinct tumors on CE, nonpolypoid and large tumors were more common in indistinct tumors on CE. In indistinct tumors even on ME, flat or depressed morphologies and type V pit were more frequently than in other groups. Sixty-five distinct tumors on CE and 18 distinct tumors on ME alone were treated endoscopically, and their R0 resection rate were 91% and 95% (p > 0.99). CONCLUSIONS: ME can improve the tumor border visibility in UC, and ER is feasible for tumors whose border can be visualized on ME.

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  • Self-Reported Medication Adherence Among Patients with Ulcerative Colitis in Japan and the United Kingdom: A Secondary Analysis for Cross-Cultural Comparison

    Aki Kawakami, Makoto Tanaka, Lee Meng Choong, Reiko Kunisaki, Shin Maeda, Ingvar Bjarnason, Bu’Hussain Hayee

    Patient Preference and Adherence   Volume 16   671 - 678   2022.3

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    DOI： 10.2147/ppa.s346309

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  • A consensus statement on health-care transition for childhood-onset inflammatory bowel disease patients. International journal

    Hideki Kumagai, Toshiaki Shimizu, Itaru Iwama, Shin-Ichiro Hagiwara, Takahiro Kudo, Michiko Takahashi, Takeshi Saito, Reiko Kunisaki, Motoi Uchino, Sakiko Hiraoka, Makoto Naganuma, Ken Sugimoto, Jun Miyoshi, Tomoyoshi Shibuya, Tadakazu Hisamatsu

    Pediatrics international : official journal of the Japan Pediatric Society   64 ( 1 )   e15241   2022.1

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    Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the intestine. The incidence of IBD is increasing worldwide, including Japan, and in approximately 25% of all affected patients it is diagnosed before 18 years of age. For the health maintenance of such patients, planned transition to adult care systems is essential. Previous Japanese surveys have revealed gaps between adult and pediatric gastroenterologists with regard to their knowledge and perception of health-care transition for patients with childhood-onset IBD. In 2021-2022, several Web workshops to discuss issues related to the transitional care of IBD patients were held by the Ministry of Health, Labour and Welfare of Japan as part of their program for research on intractable diseases. Clinicians experienced in IBD treatment for pediatric and adult patients participated. As a result, this panel of adult and pediatric gastroenterologists developed five consensus statements on the issue of "transfer from pediatric to adult care" and nine statements on the issue of "addressing transitional care (transition program)." To address current gaps in health-care transition for childhood-onset IBD patients, a programmed approach to transition, and better partnerships between pediatric and adult gastroenterologists are indicated. It is hoped that this consensus statement will provide a basis for the development of appropriate guidelines for clinical practice.

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  • 炎症性腸疾患に対する抗TNF抗体治療中に発生した高安動脈炎に関する検討

    松根 佑典, 高山 純佳, 竹内 加奈, 渡部 衛, 中森 義典, 平山 敦大, 豊田 純哉, 池田 礼, 班目 明, 小柏 剛, 松林 真央, 藤井 彩子, 芝田 渉, 木村 英明, 国崎 玲子

    日本消化器病学会雑誌   118 ( 臨増大会 )   A680 - A680   2021.10

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  • Simultaneous Development of Ulcerative Colitis in the Sigmoidocolon Autotransplant Neovagina and the Residual Colorectum. International journal

    Yusuke Matsune, Katsuki Yaguchi, Shin Saito, Hideya Sakakibara, Yoshiaki Inayama, Hideaki Kimura, Reiko Kunisaki

    Inflammatory bowel diseases   2021.8

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    DOI： 10.1093/ibd/izab222

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  • Accuracy of Ultrasound for Evaluation of Colorectal Segments in Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis

    Shintaro Sagami, Taku Kobayashi, Yusuke Miyatani, Shinji Okabayashi, Hajime Yamazaki, Toshihiko Takada, Kenji Kinoshita, Mariangela Allocca, Reiko Kunisaki, Pradeep Kakkadasam Ramaswamy, Manabu Shiraki, Toshifumi Hibi, Yuki Kataoka

    Clinical Gastroenterology and Hepatology   19 ( 5 )   908 - 921.e6   2021.5

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    DOI： 10.1016/j.cgh.2020.07.067

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  • An endoscopic treatment strategy for superficial tumors in patients with ulcerative colitis. International journal

    Masafumi Nishio, Kingo Hirasawa, Yuichiro Ozeki, Atsushi Sawada, Ryosuke Ikeda, Takehide Fukuchi, Ryosuke Kobayashi, Makomo Makazu, Chiko Sato, Reiko Kunisaki, Shin Maeda

    Journal of gastroenterology and hepatology   36 ( 2 )   498 - 506   2021.2

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    BACKGROUND AND AIM: Endoscopic resection is feasible for superficial tumors in patients with ulcerative colitis; however, endoscopic resection options have not been evaluated comprehensively. We evaluated the efficacy and safety of endoscopic submucosal dissection and endoscopic mucosal resection, and decision making regarding endoscopic resection options for patients with ulcerative colitis. METHODS: Endoscopically treated tumors from patients with ulcerative colitis were analyzed retrospectively. We evaluated en bloc and R0 resection, adverse events, local tumor recurrence, and metachronous lesion occurrence rates. RESULTS: We examined 102 tumors (mean size, 12 mm; non-polypoid, 55 tumors) from 74 patients with ulcerative colitis, of whom, 39 and 63 underwent endoscopic submucosal dissection and endoscopic mucosal resection, respectively. The R0 resection rate was significantly higher for endoscopic submucosal dissection (97%) than for endoscopic mucosal resection (80%) (P = 0.0015). For 11-20-mm tumors, the R0 resection rate was significantly higher for endoscopic submucosal dissection (94%) than for endoscopic mucosal resection (55%) (P = 0.0027); the endoscopic submucosal dissection and endoscopic mucosal resection R0 rates did not differ for ≤ 10-mm tumors. The non-polypoid tumor R0 resection rates were significantly higher for endoscopic submucosal dissection (100%) than for endoscopic mucosal resection (65%) (P < 0.001) and did not differ regarding the polypoid tumor R0 resection rates (75% vs 86%, P = 0.49). Four patients experienced intraoperative perforation during endoscopic submucosal dissection. No local recurrences occurred. Metachronous high-grade dysplasia occurred in three patients during surveillance. CONCLUSIONS: In patients with ulcerative colitis, endoscopic submucosal dissection is suitable for ≥ 11-mm and non-polypoid tumors, whereas endoscopic mucosal resection is acceptable for ≤ 10-mm tumors.

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  • Validity and Reliability of the Japanese Version of the Morisky Medication Adherence Scale-8 in Patients with Ulcerative Colitis

    Makoto Tanaka, Aki Kawakami, Shin Maeda, Reiko Kunisaki, Donald E. Morisky

    Gastroenterology Nursing   44 ( 1 )   31 - 38   2021.1

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    DOI： 10.1097/SGA.0000000000000533

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  • Phenotypic characteristics of pediatric inflammatory bowel disease in Japan: results from a multicenter registry. International journal

    Katsuhiro Arai, Reiko Kunisaki, Fumihiko Kakuta, Shin-Ichiro Hagiwara, Takatsugu Murakoshi, Tadahiro Yanagi, Toshiaki Shimizu, Sawako Kato, Takashi Ishige, Tomoki Aomatsu, Mikihiro Inoue, Takeshi Saito, Itaru Iwama, Hisashi Kawashima, Hideki Kumagai, Hitoshi Tajiri, Naomi Iwata, Takahiro Mochizuki, Atsuko Noguchi, Toshihiko Kashiwabara, Hirotaka Shimizu, Yasuo Suzuki, Yuri Hirano, Takeo Fujiwara

    Intestinal research   18 ( 4 )   412 - 420   2020.10

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    BACKGROUND/AIMS: There are few published registry studies from Asia on pediatric inflammatory bowel disease (IBD). Registry network data enable comparisons among ethnic groups. This study examined the characteristics of IBD in Japanese children and compared them with those in European children. METHODS: This was a cross-sectional multicenter registry study of newly diagnosed Japanese pediatric IBD patients. The Paris classification was used to categorize IBD features, and results were compared with published EUROKIDS data. RESULTS: A total of 265 pediatric IBD patients were initially registered, with 22 later excluded for having incomplete demographic data. For the analysis, 91 Crohn's disease (CD), 146 ulcerative colitis (UC), and 6 IBD-unclassified cases were eligible. For age at diagnosis, 20.9% of CD, 21.9% of UC, and 83.3% of IBD-unclassified cases were diagnosed before age 10 years. For CD location, 18.7%, 13.2%, 64.8%, 47.3%, and 20.9% were classified as involving L1 (ileocecum), L2 (colon), L3 (ileocolon), L4a (esophagus/stomach/duodenum), and L4b (jejunum/proximal ileum), respectively. For UC extent, 76% were classified as E4 (pancolitis). For CD behavior, B1 (non-stricturing/non-penetrating), B2 (stricturing), B3 (penetrating), and B2B3 were seen in 83.5%, 11.0%, 3.3%, and 2.2%, respectively. A comparison between Japanese and European children showed less L2 involvement (13.2% vs. 27.3%, P< 0.01) but more L4a (47.3% vs. 29.6%, P< 0.01) and L3 (64.8% vs. 52.7%, P< 0.05) involvement in Japanese CD children. Pediatric perianal CD was more prevalent in Japanese children (34.1% vs. 9.7%, P< 0.01). CONCLUSIONS: Upper gastrointestinal and perianal CD lesions are more common in Japanese children than in European children.

    DOI： 10.5217/ir.2019.00130

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  • 大腸鋸歯状腫瘍の内視鏡診断と治療の現状 潰瘍性大腸炎の炎症範囲内に合併した鋸歯状病変の特徴

    西尾 匡史, 前田 愼, 国崎 玲子

    Gastroenterological Endoscopy   62 ( Suppl.2 )   1996 - 1996   2020.10

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  • Long-term follow-up of targeted biopsy yield (LOFTY study) in ulcerative colitis surveillance colonoscopy

    Keisuke Hata, Soichiro Ishihara, Yoichi Ajioka, Keiichi Mitsuyama, Kenji Watanabe, Hiroyuki Hanai, Reiko Kunisaki, Hiroshi Nakase, Keiji Matsuda, Ryuichi Iwakiri, Nobuyuki Hida, Shinji Tanaka, Yoshiaki Takeuchi, Masaru Shinozaki, Noriyuki Ogata, Kentaro Moriichi, Fumihito Hirai, Kenichi Sugihara, Tadakazu Hisamatsu, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi

    Journal of Clinical Medicine   9 ( 7 )   1 - 15   2020.7

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    DOI： 10.3390/jcm9072286

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  • Evidence-based diagnosis and clinical practice guidelines for intestinal Behçet's disease 2020 edited by Intractable Diseases, the Health and Labour Sciences Research Grants.

    Kenji Watanabe, Satoshi Tanida, Nagamu Inoue, Reiko Kunisaki, Kiyonori Kobayashi, Masakazu Nagahori, Katsuhiro Arai, Motoi Uchino, Kazutaka Koganei, Taku Kobayashi, Mitsuhiro Takeno, Fumiaki Ueno, Takayuki Matsumoto, Nobuhisa Mizuki, Yasuo Suzuki, Tadakazu Hisamatsu

    Journal of gastroenterology   55 ( 7 )   679 - 700   2020.7

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    Behçet's disease (BD) is an intractable systemic inflammatory disease characterized by four main symptoms: oral and genital ulcers and ocular and cutaneous involvement. The Japanese diagnostic criteria of BD classify intestinal BD as a specific disease type. Volcano-shaped ulcers in the ileocecum are a typical finding of intestinal BD, and punched-out ulcers can be observed in the intestine or esophagus. Tumor necrosis factor inhibitors were first approved for the treatment of intestinal BD in Japan and have been used as standard therapy. In 2007 and 2014, the Japan consensus statement for the diagnosis and management of intestinal BD was established. Recently, evidence-based JSBD (Japanese Society for BD) Clinical Practice Guidelines for BD (Japanese edition) were published, and the section on intestinal BD was planned to be published in English. Twenty-eight important clinical questions (CQs) for diagnosis (CQs 1-6), prognosis (CQ 7), monitoring and treatment goals (CQs 8-11), medical management and general statement (CQs 12-13), medical treatment (CQs 14-22), and surgical treatment (CQs 23-25) of BD and some specific situations (CQs 26-28) were selected as unified consensus by the members of committee. The statements and comments were made following a search of published scientific evidence. Subsequently, the levels of recommendation were evaluated based on clinical practice guidelines in the Medical Information Network Distribution Service. The degree of agreement was calculated using anonymous voting. We also determined algorithms for diagnostic and therapeutic approaches for intestinal BD. The present guidelines will facilitate decision making in clinical practice.

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  • Potential Inhibition of COVID-19-driven Pneumonia by Immunosuppressive Therapy and anti-TNFα Antibodies: A Case Report

    Reiko Kunisaki, Jun Tsukiji, Makoto Kudo

    Journal of Crohn's and Colitis   14 ( 12 )   1786 - 1787   2020.5

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    DOI： 10.1093/ecco-jcc/jjaa105

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  • Successful Treatment With Ustekinumab for Enterocutaneous Fistulas in Crohn's Disease. International journal

    Akira Madarame, Hideaki Kimura, Reiko Kunisaki

    Journal of Crohn's & colitis   14 ( 4 )   569 - 570   2020.5

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    DOI： 10.1093/ecco-jcc/jjz161

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  • Consistency of Trans-Abdominal and Water-Immersion Ultrasound Images of Diseased Intestinal Segments in Crohn's Disease. Reviewed International journal

    Feiqian Wang, Kazushi Numata, Hiromi Yonezawa, Kana Sato, Yoshito Ishii, Katsuki Yaguchi, Nao Kume, Yu Hashimoto, Masafumi Nishio, Yoshinori Nakamori, Aya Ikeda, Akira Madarame, Atsuhiro Hirayama, Tsuyoshi Ogashiwa, Tomohiko Sasaki, Misato Jin, Akiho Hanzawa, Naomi Shibata, Shinichi Hashimorto, Yusuke Saigusa, Yoshiaki Inayama, Shin Maeda, Hideaki Kimura, Reiko Kunisaki

    Diagnostics (Basel, Switzerland)   10 ( 5 )   2020.4

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    The aim of this study is to clarify whether trans-abdominal ultrasound (TAUS) can reflect actual intestinal conditions in Crohn's disease (CD) as effectively as water-immersion ultrasound (WIUS) does. This retrospective study enrolled 29 CD patients with 113 intestinal lesions. Five ultrasound (US) parameters (distinct presence/indistinct presence/disappearance of wall stratification in the submucosal and mucosal layers; thickened submucosal layer; irregular mucosal surface; increased fat wrapping around the bowel wall; and fistula signs) that may indicate different states in CD were determined by TAUS and WIUS for the same lesion. Using WIUS as a reference standard, the sensitivity, specificity, and accuracy of TAUS were calculated. The degree of agreement between TAUS and WIUS was evaluated by the kappa coefficient. All US parameters of TAUS had an accuracy >70% (72.6-92.7%). The highest efficacy of TAUS was obtained for fistula signs (sensitivity, specificity, and accuracy values were 63.6%, 96.0%, and 92.7%, respectively). All US parameters between TAUS and WIUS had a definitive (p ≤ 0.001) and moderate-to-substantial consistency (kappa value = 0.446-0.615). The images of TAUS showed substantial similarity to those of WIUS, suggesting that TAUS may function as a substitute to evaluate the actual intestinal conditions of CD.

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  • Non-adherence to Medications in Pregnant Ulcerative Colitis Patients Contributes to Disease Flares and Adverse Pregnancy Outcomes

    Chikako Watanabe, Masakazu Nagahori, Toshimitsu Fujii, Kaoru Yokoyama, Naoki Yoshimura, Taku Kobayashi, Hirokazu Yamagami, Kazuya Kitamura, Kagaya Takashi, Shiro Nakamura, Makoto Naganuma, Shunji Ishihara, Motohiro Esaki, Maria Yonezawa, Reiko Kunisaki, Atsushi Sakuraba, Naoaki Kuji, Soichiro Miura, Toshifumi Hibi, Yasuo Suzuki, Ryota Hokari

    Digestive Diseases and Sciences   66 ( 2 )   577 - 586   2020.4

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    DOI： 10.1007/s10620-020-06221-6

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  • 「炎症性腸疾患:シームレスなアプローチを目指して」-Special situationにおけるこれからの課題:疾病負荷(Disease burden)を含めて- 小児期発症炎症性腸疾患患者のトランジション Reviewed

    熊谷 秀規, 清水 俊明, 工藤 孝広, 内田 恵一, 国崎 玲子, 杉田 昭, 大塚 宜一, 新井 勝大, 窪田 満, 田尻 仁, 鈴木 康夫

    日本消化管学会雑誌   4 ( Suppl. )   140 - 140   2020.1

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  • Uselessness of serum p53 antibody for detecting colitis-associated cancer in the era of immunosuppressive therapy

    Kenichiro Toritani, Hideaki Kimura, Reiko Kunisaki, Jun Watanabe, Chikara Kunisaki, Atsushi Ishibe, Sawako Chiba, Yoshiaki Inayama, Itaru Endo

    In Vivo   34 ( 2 )   723 - 728   2020

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    DOI： 10.21873/invivo.11830

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  • 小児潰瘍性大腸炎治療指針(2019年) Reviewed

    虻川 大樹, 青松 友槻, 井上 幹大, 岩間 達, 熊谷 秀規, 清水 泰岳, 神保 圭佑, 南部 隆亮, 水落 建輝, 内田 恵一, 国崎 玲子, 石毛 崇, 福岡 智哉, 新井 勝大, 清水 俊明, 田尻 仁, 日本小児栄養消化器肝臓学会・日本小児IBD研究会小児IBD治療指針2019改訂ワーキンググループ

    日本小児栄養消化器肝臓学会雑誌   33 ( 2 )   110 - 127   2019.12

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  • 小児クローン病治療指針(2019年)

    新井 勝大, 工藤 孝広, 熊谷 秀規, 齋藤 武, 清水 泰岳, 高橋 美智子, 立花 奈緒, 南部 隆亮, 内田 恵一, 国崎 玲子, 石毛 崇, 福岡 智哉, 虻川 大樹, 清水 俊明, 田尻 仁, 日本小児栄養消化器肝臓学会・日本小児IBD研究会小児IBD治療指針2019改訂ワーキンググループ

    日本小児栄養消化器肝臓学会雑誌   33 ( 2 )   90 - 109   2019.12

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  • Correlation between the macroscopic severity of Crohn's disease in resected intestine and bowel wall thickness evaluated by water-immersion ultrasonography. Reviewed International journal

    Katsuki Yaguchi, Tomohiko Sasaki, Tsuyoshi Ogashiwa, Masafumi Nishio, Yu Hashimoto, Aya Ikeda, Misato Izumi, Akiho Hanzawa, Naomi Shibata, Hiromi Yonezawa, Kentaro Sakamaki, Yoko Tateishi, Kazushi Numata, Shin Maeda, Hideaki Kimura, Reiko Kunisaki

    Scandinavian journal of gastroenterology   54 ( 11 )   1331 - 1338   2019.11

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    Objectives: Transabdominal ultrasonography is a common and accurate tool for managing Crohn's disease (CD); however, the significance of the resulting data is poorly understood. This study was performed to determine the association between bowel wall thickness evaluated by water-immersion ultrasonography and macroscopic severity, namely, refractory inflammation and subsequent fibrosis in CD surgical specimens.Materials and methods: We retrospectively evaluated 100 segments of colon and small intestine from 27 patients with CD. The resected specimens were placed in saline postoperatively, and bowel wall thickness was measured by water-immersion ultrasonography and compared with macroscopic findings. Correlations between bowel wall thickness and macroscopic findings were assessed using analysis of variance and receiver operating characteristic curves.Results: According to the progression of macroscopic severity, the mean bowel wall thickness was increased as follows: macroscopically intact: 4.1 mm, longitudinal ulcer scars: 5.4 mm, longitudinal open ulcers: 6.0 mm, large ulcers: 6.4 mm, cobblestone-like lesions: 7.1 mm, and fibrotic strictures: 7.4 mm. For all lesions except longitudinal ulcer scars, the bowel wall thickness was significantly thicker than that of macroscopically-intact areas (p < .001). According to receiver operating characteristic curves, bowel wall thickness >4.5 mm was associated with CD lesions, and thickness >5.5 mm was associated with more severe lesions.Conclusions: The bowel wall thickness of CD lesions was evaluated by water-immersion ultrasonography correlated with macroscopic disease severity.

    DOI： 10.1080/00365521.2019.1683224

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  • Validation of the English version of the difficulty of life scale for patients with ulcerative colitis. Reviewed

    Kawakami A, Choong LM, Tanaka M, Kunisaki R, Maeda S, Bjarnason I, Hayee B

    European journal of gastroenterology & hepatology   2019.11

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  • Remission induction, maintenance, and endoscopic outcome with oral 5-aminosalicylic acid in intestinal Behçet's disease. Reviewed

    Kinoshita H, Nishioka H, Ikeda A, Ikoma K, Sameshima Y, Ohi H, Tatsuno M, Kouyama J, Kawamoto C, Mitsui T, Tamura Y, Hashimoto Y, Nishio M, Ogashiwa T, Saigusa Y, Maeda S, Kimura H, Kunisaki R, Koike K

    Journal of gastroenterology and hepatology   34 ( 11 )   1929 - 1939   2019.11

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  • Withdrawal of thiopurines in Crohn's disease treated with scheduled adalimumab maintenance: a prospective randomised clinical trial (DIAMOND2). Reviewed

    Hisamatsu T, Kato S, Kunisaki R, Matsuura M, Nagahori M, Motoya S, Esaki M, Fukata N, Inoue S, Sugaya T, Sakuraba H, Hirai F, Watanabe K, Kanai T, Naganuma M, Nakase H, Suzuki Y, Watanabe M, Hibi T, Nojima M, Matsumoto T, DIAMOND, Study Group

    Journal of gastroenterology   54 ( 10 )   860 - 870   2019.10

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  • Tacrolimus for ulcerative colitis in children: a multicenter survey in Japan. Reviewed International journal

    Tadahiro Yanagi, Kosuke Ushijima, Hidenobu Koga, Takeshi Tomomasa, Hitoshi Tajiri, Reiko Kunisaki, Takashi Isihige, Hiroyuki Yamada, Katsuhiro Arai, Atsushi Yoden, Tomoki Aomatsu, Satoru Nagata, Keiichi Uchida, Yoshikazu Ohtsuka, Toshiaki Shimizu

    Intestinal research   17 ( 4 )   476 - 485   2019.10

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    BACKGROUND/AIMS: Tacrolimus is effective for refractory ulcerative colitis in adults, while data for children is sparse. We aimed to evaluate the effectiveness and safety of tacrolimus for induction and maintenance therapy in Japanese children with ulcerative colitis. METHODS: We retrospectively reviewed the multicenter survey data of 67 patients with ulcerative colitis aged < 17 years treated with tacrolimus between 2000 and 2012. Patients' characteristics, disease activity, Pediatric Ulcerative Colitis Activity Index (PUCAI) score, initial oral tacrolimus dose, short-term (2-week) and long-term (1-year) outcomes, steroid-sparing effects, and adverse events were evaluated. Clinical remission was defined as a PUCAI score < 10; treatment response was defined as a PUCAI score reduction of ≥ 20 points compared with baseline. RESULTS: Patients included 35 boys and 32 girls (median [interquartile range] at admission: 13 [11-15] years). Thirty-nine patients were steroid-dependent and 26 were steroidrefractory; 20 had severe colitis and 43 had moderate colitis. The initial tacrolimus dose was 0.09 mg/kg/day (range, 0.05-0.12 mg/kg/day). The short-term clinical remission rate was 47.8%, and the clinical response rate was 37.3%. The mean prednisolone dose was reduced from 19.2 mg/day at tacrolimus initiation to 5.7 mg/day at week 8 (P< 0.001). The adverse event rate was 53.7%; 6 patients required discontinuation of tacrolimus therapy. CONCLUSIONS: Tacrolimus was a safe and effective second-line induction therapy for steroid-dependent and steroid-refractory ulcerative colitis in Japanese children.

    DOI： 10.5217/ir.2019.00027

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  • Adult Gastroenterologists’ Views on Transitional Care: Results from a Survey Reviewed

    Kumagai H, Kudo T, Uchida K, Kunisaki R, Sugita A, Ohtsuka Y, Arai K, Kubota M, Tajiri H, Suzuki Y, Shimizu T

    Pediatr Int   61 ( 8 )   817 - 822   2019.8

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  • Concerns and Side Effects of Azathioprine During Adalimumab Induction and Maintenance Therapy for Japanese Patients With Crohn’s Disease: A Subanalysis of a Prospective Randomised Clinical Trial [DIAMOND Study]

    Tadakazu Hisamatsu, Takayuki Matsumoto, Kenji Watanabe, Hiroshi Nakase, Satoshi Motoya, Naoki Yoshimura, Tetsuya Ishida, Shingo Kato, Tomoo Nakagawa, Motohiro Esaki, Masakazu Nagahori, Toshiyuki Matsui, Yuji Naito, Takanori Kanai, Yasuo Suzuki, Masanori Nojima, Mamoru Watanabe, Toshifumi Hibi, Akira Andoh, Toshifumi Ashida, Katsuya Endo, Yutaka Endo, Motohiro Esaki, Hiroshi Fujita, Mikihiro Fujiya, Ken Haruma, Toshifumi Hibi, Sakiko Hiraoka, Ichiro Hirata, Tadakazu Hisamatsu, Yutaka Honda, Hideki Iijima, Bunei Iizuka, Kentaro Ikeya, Takuya Inoue, Syuji Inoue, Tetsuya Ishida, Yo Ishiguro, Shunji Ishihara, Hiroaki Ito, Ryuichi Iwakiri, Takashi Kagaya, Takanori Kanai, Hiroshi Kashida, Shingo Kato, Jun Kato, Takehiko Katsurada, Fukunori Kinjyo, Kiyonori Kobayashi, Mayumi Kodama, Reiko Kunisaki, Koichi Kurahara, Takafumi Kurokami, Lee Kyouwon, Koichiro Matsuda, Kazuhiro Matsueda, Toshiyuki Matsui, Takayuki Matsumoto, Keiichi Mitsuyama, Yuji Mizokami, Satoshi Motoya, Yuji Naito, Tomoo Nakagawa, Shiro Nakamura, Hiroshi Nakase, Masanori Nojima, Masafumi Nomura, Atsuhiro Ogawa, Kazuichi Okazaki, Kazuaki Otsuka, Hirotake Sakuraba, Masayuki Saruta, Makoto Sasaki, Takayuki Shirai, Tomoaki Suga, Kazuhito Sugimura, Toshiro Sugiyama, Yasuo Suzuki, Fuminao Takeshima, Hiroyuki Tamaki, Shinji Tanaka, Satoshi Tanida, Keiichi Tominaga, Taku Tomizawa, Kenji Watanabe, Mamoru Watanabe, Kenji Watanabe, Syojiro Yamamoto, Masaki Yamashita, Atsushi Yoshida, Naoki Yoshimura

    Journal of Crohn's and Colitis   13 ( 9 )   1097 - 1104   2019.2

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    Abstract

    Background

    Combining a thiopurine with the human anti-tumour necrosis factor-α monoclonal antibody adalimumab for Crohn’s disease [CD] treatment is controversial with regard to efficacy and safety. By conducting a subanalysis of a multicentre, randomised, prospective, open-label trial [the DIAMOND study, UMIN registration number 000005146], we studied the risk of discontinuation of thiopurine in combination with adalimumab.

    Methods

    In the preceding DIAMOND study, we analysed the: [i] timing and reasons for dropout in the monotherapy group and combination group; [ii] risk factors for dropout in the combination group.

    Results

    There was no significant difference in the dropout rate up to Week 52 between the monotherapy group and combination group [p = 0.325]. The main reason for study dropout was active CD in the monotherapy group, whereas it was adverse effects in the combination group [Fisher’s exact test, p &lt;0.001]. Kaplan–Meier analyses revealed significantly earlier dropout in the combination group [log-rank test, p = 0.001]. Multivariable analysis revealed low body weight to be a risk for dropout due to adverse effects in the combination group.

    Conclusions

    Combination of azathioprine with adalimumab resulted in dropout in the early stage of the study due to side effects of azathioprine, in comparison with late dropout due to active CD in the adalimumab monotherapy group.

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  • Short- and long-term efficacy of adalimumab salvage therapy after failure of calcineurin inhibitors in steroid-refractory ulcerative colitis. Reviewed

    Nishio M, Ishii Y, Hashimoto Y, Otake H, Ogashiwa T, Tsuda S, Yasuhara H, Saigusa Y, Kimura H, Maeda S, Kunisaki R

    Scandinavian journal of gastroenterology   1 - 9   2018.10

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  • Patient self-reported symptoms using visual analog scales are useful to estimate endoscopic activity in ulcerative colitis. International journal

    Saya Tsuda, Reiko Kunisaki, Jun Kato, Mayu Murakami, Masafumi Nishio, Tsuyoshi Ogashiwa, Takeichi Yoshida, Hideaki Kimura, Masayuki Kitano

    Intestinal research   16 ( 4 )   579 - 587   2018.10

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    BACKGROUND/AIMS: In clinical practice, colonoscopy has been regarded as the gold standard for the evaluation of disease severity as well as mucosal healing in ulcerative colitis (UC). Some activity indices incorporating patient symptoms as parameters have been shown to reflect the endoscopic activity of UC. The aim of this study was to examine whether self-reported symptoms with visual analog scales (VAS) can predict endoscopic activity. METHODS: A cross-sectional study of 150 UC patients who underwent colonoscopy with submission of VAS scores of 4 symptoms: general condition, bloody stools, stool form, and abdominal pain (0: no symptoms, 10: the most severe symptoms). Each VAS score was compared with colonoscopic activity assessed with the Mayo endoscopic subscore (MES). RESULTS: All VAS scores were significantly correlated with the endoscopic severity (Spearman correlation coefficients of general condition, bloody stools, stool form, and abdominal pain: 0.63, 0.64, 0.58, and 0.43, respectively). Mucosal healing defined as MES 0 alone was predicted by VAS score <1.5 on general condition or 0 on bloody stools with sensitivity of 0.84 and 0.76 and specificity of 0.66 and 0.76, respectively. Additionally, VAS score <2.5 on stool form predicted active lesions in distal colorectum alone with sensitivity of 0.67 and specificity of 0.66, suggesting that this item could predict the indication of topical therapy. CONCLUSIONS: Self-reported VAS scores on symptoms were correlated with endoscopic activity of UC. To clarify the relationship between VAS and mucosal healing, further validation studies are needed.

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  • Surveillance for dysplasia in patients with ulcerative colitis : Discrepancy between guidelines and practice

    Shinozaki M, Kobayashi K, Kunisaki R, Hisamatsu T, Naganuma M, Takahashi K, Iwao Y, Suzuki Y, Watanabe M, Itabashi M, Torii A, Takazoe M, Sugita A

    Gastroenterological Endoscopy   60 ( 4 )   1033 - 1043   2018.4

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    © 2018 Japan Gastroenterological Endoscopy Society. All righrts reserved. Background and Aim : The risk of developing colorectal cancer is higher in patients with ulcerative colitis (UC) than in the general population. Guidelines recommend surveillance colonoscopy (SCS) to reduce mortality ; however, few studies have assessed physicians&#039; adherence to guidelines. This study was aimed to clarify the current status of SCS and adherence to guidelines through the characteristics of cancer/dysplasia surveillance for UC patients in Japan. Methods : A questionnaire was mailed to 541 physicians who attended meetings on inflammatory bowel disease. Results : The respondents encountered a median of 100 UC cases. Thirty percent of the respondents had never managed a UC patient with cancer. Fifty-one percent of the respondents had never diagnosed colorectal cancer with UC. Forty-seven percent of the respondents considered extensive colitis and left-sided colitis as indications for SCS, and 38% carried out SCS regardless of the disease extent. Sixty-three percent of the respondents started SCS at 7-10 years after UC onset, whereas 20% started SCS at 3 years or less. Fifty-two percent of the resp

    DOI： 10.11280/gee.60.1033

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  • Evidence-based clinical practice guidelines for inflammatory bowel disease. Reviewed

    Matsuoka K, Kobayashi T, Ueno F, Matsui T, Hirai F, Inoue N, Kato J, Kobayashi K, Kobayashi K, Koganei K, Kunisaki R, Motoya S, Nagahori M, Nakase H, Omata F, Saruta M, Watanabe T, Tanaka T, Kanai T, Noguchi Y, Takahashi KI, Watanabe K, Hibi T, Suzuki Y, Watanabe M, Sugano K, Shimosegawa T

    Journal of gastroenterology   53 ( 3 )   305 - 353   2018.3

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  • Effect of Elemental Diet Combined with Infliximab dose escalation in Patients with Crohn’s Disease with Loss of Response to Infliximab: CERISIER Trial. Reviewed

    Hisamatsu T, Kunisaki R, Nakamura S, Tsujikawa T, Hirai F, Nakase H, Watanabe K, Yokoyama K, Nagahori M, Kanai T, Naganuma M, Michimae H, Andoh A, Yamada A, Yokoyama T, Kamata N, Tanaka S, Suzuki Y, Hibi T, Watanabe M, CERISIER Trial group

    Intest Res.   16   494 - 498   2018

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  • Incidence and Outcomes of Central Venous Catheter–related Blood Stream Infection in Patients with Inflammatory Bowel Disease in Routine Clinical Practice Setting Reviewed

    Wataru Shibata, Masako Sohara, Rongrong Wu, Kota Kobayashi, Shin Yagi, Katsuki Yaguchi, Yuki Iizuka, Miho Iwasa, Hitomi Nakahata, Tadashi Yamaguchi, Hiromi Matsumoto, Mao Okada, Kenshiro Taniguchi, Aki Hayashi, Shin Inazawa, Naoko Inagaki, Tomohiko Sasaki, Ryonho Koh, Hiroto Kinoshita, Masafumi Nishio, Tsuyoshi Ogashiwa, Ai Ookawara, Eiji Miyajima, Mari Oba, Hiroki Ohge, Shin Maeda, Hideaki Kimura, Reiko Kunisaki

    Inflammatory Bowel Diseases   23 ( 11 )   2042 - 2047   2017.11

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    DOI： 10.1097/mib.0000000000001230

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  • Surveillance for dysplasia in patients with ulcerative colitis: Discrepancy between guidelines and practice Reviewed

    Masaru Shinozaki, Kiyonori Kobayashi, Reiko Kunisaki, Tadakazu Hisamatsu, Makoto Naganuma, Ken-Ichi Takahashi, Yasushi Iwao, Yasuo Suzuki, Mamoru Watanabe, Michio Itabashi, Akira Torii, Masakazu Takazoe, Akira Sugita

    Digestive Endoscopy   29 ( 5 )   584 - 593   2017.7

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    DOI： 10.1111/den.12803

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  • Treatment with infliximab for pediatric Crohn's disease: Nationwide survey of Japan Reviewed

    Kenji Hosoi, Yoshikazu Ohtsuka, Tohru Fujii, Takahiro Kudo, Nobuaki Matsunaga, Takeshi Tomomasa, Hitoshi Tajiri, Reiko Kunisaki, Takashi Ishige, Hiroyuki Yamada, Katsuhiro Arai, Atsushi Yoden, Kosuke Ushijima, Tomoki Aomatsu, Satoru Nagata, Keiichi Uchida, Kazuo Takeuchi, Toshiaki Shimizu

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 ( 1 )   114 - 119   2017.1

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    DOI： 10.1111/jgh.13498

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  • Hematopoietic Stem Cell Transplantation for XIAP Deficiency in Japan.

    Shintaro Ono, Tsubasa Okano, Akihiro Hoshino, Masakatsu Yanagimachi, Kazuko Hamamoto, Yozo Nakazawa, Toshihiko Imamura, Masaei Onuma, Hidetaka Niizuma, Yoji Sasahara, Hiroshi Tsujimoto, Taizo Wada, Reiko Kunisaki, Masatoshi Takagi, Kohsuke Imai, Tomohiro Morio, Hirokazu Kanegane

    J. Clin. Immunol.   37 ( 1 )   85 - 91   2017

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    DOI： 10.1007/s10875-016-0348-4

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  • Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-Associated Colorectal Cancer. Reviewed International journal

    Toshiaki Watanabe, Yoichi Ajioka, Keiichi Mitsuyama, Kenji Watanabe, Hiroyuki Hanai, Hiroshi Nakase, Reiko Kunisaki, Keiji Matsuda, Ryuichi Iwakiri, Nobuyuki Hida, Shinji Tanaka, Yoshiaki Takeuchi, Kazuo Ohtsuka, Kazunari Murakami, Kiyonori Kobayashi, Yasushi Iwao, Masakazu Nagahori, Bunei Iizuka, Keisuke Hata, Masahiro Igarashi, Ichiro Hirata, Shin-Ei Kudo, Takayuki Matsumoto, Fumiaki Ueno, Gen Watanabe, Masahiro Ikegami, Yoko Ito, Koji Oba, Eisuke Inoue, Naoki Tomotsugu, Toru Takebayashi, Kenichi Sugihara, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi

    Gastroenterology   151 ( 6 )   1122 - 1130   2016.12

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    BACKGROUND & AIMS: A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted vs random biopsies in patients with UC. METHODS: We performed a study of 246 patients with UC for 7 years or more, seen at 52 institutions in Japan from October 1, 2008 through December 31, 2010. Patients were randomly assigned to the random group (4 random biopsies collected every 10 cm in addition to targeted biopsies, n = 122) or the target group (biopsies collected from locations of suspected neoplasia, n = 124). The primary end point was the number of neoplastic lesions detected in a single surveillance colonoscopy. We estimated the ratio and difference in the mean number of neoplastic lesions between the groups. We also evaluated the non-inferiority between the groups as an exploratory study. A non-inferiority margin of 0.65 (0.13 of 0.20) was considered for the ratio of the mean number of neoplastic lesions between groups. RESULTS: The mean number of biopsies found to contain neoplastic tissue per colonoscopy was 0.211 (24 of 114) in the target group and 0.168 (18 of 107) in the random group (ratio of 1.251; 95% confidence interval, 0.679-2.306). The lower limit was above the non-inferiority margin of 0.65. Neoplasias were detected in 11.4% of patients in the target group and 9.3% of patients in the random group (P = .617). Larger numbers of biopsy samples per colonoscopy were collected in the random group (34.8 vs 3.1 in the target group; P < .001), and the total examination time was longer (41.7 vs 26.6 minutes in the target group; P < .001). In the random group, all neoplastic tissues found in random biopsies were collected from areas of the mucosa with a history or presence of inflammation. CONCLUSIONS: In a randomized controlled trial, we found that targeted and random biopsies detect similar proportions of neoplasias. However, a targeted biopsy appears to be a more cost-effective method. Random biopsies from areas without any signs of present or past inflammation were not found to contain neoplastic tissues. Clinical Trial Registry: UMIN000001608.

    DOI： 10.1053/j.gastro.2016.08.002

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  • Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease Reviewed

    Brian G. Feagan, William J. Sandborn, Christopher Gasink, Douglas Jacobstein, Yinghua Lang, Joshua R. Friedman, Marion A. Blank, Jewel Johanns, Long-Long Gao, Ye Miao, Omoniyi J. Adedokun, Bruce E. Sands, Stephen B. Hanauer, Severine Vermeire, Stephan Targan, Subrata Ghosh, Willem J. de Villiers, Jean-Frédéric Colombel, Zsolt Tulassay, Ursula Seidler, Bruce A. Salzberg, Pierre Desreumaux, Scott D. Lee, Edward V. Loftus, Levinus A. Dieleman, Seymour Katz, Paul Rutgeerts

    New England Journal of Medicine   375 ( 20 )   1946 - 1960   2016.11

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    DOI： 10.1056/nejmoa1602773

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  • Pregnancy outcome in women with inflammatory bowel disease treated with anti-tumor necrosis factor and/or thiopurine therapy: a multicenter study from Japan. Reviewed

    Komoto S, Motoya S, Nishiwaki Y, Matsui T, Kunisaki R, Matsuoka K, Yoshimura N, Kagaya T, Naganuma M, Hida N, Watanabe M, Hibi T, Suzuki Y, Miura S, Hokari R, Japanese study group for pregnant women with IBD

    Intestinal research   14 ( 2 )   139 - 145   2016.4

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  • A screening instrument to identify ulcerative colitis patients with the high possibility of current non-adherence to aminosalicylate medication based on the Health Belief Model: a cross-sectional study. Reviewed

    Kawakami A, Tanaka M, Nishigaki M, Yoshimura N, Suzuki R, Maeda S, Kunisaki R, Yamamoto-Mitani N

    BMC Gastroenterol.   19   220   2015.11

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  • Surgical colitis associated with cancer complicated with ulcerative colitis

    Koki Goto, Hideaki Kimura, Saya Tsuda, Tsuyoshi Ogashiwa, Hisae Yasuhara, Ryonho Koh, Reiko Kunisaki, Itaru Endo

    Yokohama Medical Journal   66 ( 1-2 )   31 - 38   2015

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  • Hematologic malignancies in the Japanese patients with inflammatory bowel disease

    Norimasa Fukata, Kazuichi Okazaki, Mika Omiya, Mitsunobu Matsushita, Mamoru Watanabe, Hirohito Tsubouchi, Kozo Imai, Iwao Sasaki, Fumiaki Ueno, Yoshihide Fujiyama, Yoshio Hirota, Toshiyuki Matsui, Soichiro Miura, Toshifumi Hibi, Yutaka Kohgo, Yasuo Suzuki, Tsutomu Chiba, Yoichi Ajioka, Toshiaki Watanabe, Akira Sugita, Takayuki Matsumoto, Yoshiaki Arimura, Hideki Iijima, Bun-Ei Iizuka, Masahiro Iizuka, Hiroki Ikeuchi, Yoh Ishiguro, Shunji Ishihara, Hiroaki Ito, Yasushi Iwao, Hidehisa Ohi, Kiyotaka Okawa, Jun Kato, Shingo Kameoka, Yoshitaka Kinouchi, Atsuo Kitano, Fukunori Kinjo, Masato Kusunoki, Shin-Ei Kudo, Kiyonori Kobayashi, Hidemi Goto, Makoto Sasaki, Masayuki Saruta, Seiji Shimizu, Takashi Joh, Kazuhito Sugimura, Kenji Suzuki, Shinji Tanaka, Taeko Dohi, Yuji Naito, Atsushi Nakajima, Katsuyoshi Hatakeyama, Ken Haruma, Ichiro Hirata, Hisao Fujii, Kitaro Futami, Yuji Funayama, Keiichi Mitsuyama, Satoshi Motoya, Kazuhiko Yoshioka, Atsushi Yoden, Kenji Watanabe, Hitoshi Asakura, Tetsuichiro Muto, Akihiro Munakata, Tatsuro Katsuno, Takashi Kagaya, Katsuyuki Fukuda, Reiko Kunisaki, Hitoshi Tajiri, Takashi Ishige, Shojiro Yamamoto

    Journal of Gastroenterology   49 ( 9 )   1299 - 1306   2014.9

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    DOI： 10.1007/s00535-013-0873-3

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  • 同種造血幹細胞移植後腸管GVHDにおける体外式腸管超音波検査の有用性

    小柏 剛, 国崎 玲子, 津田 沙耶, 安原 ひさ恵, 高 蓮浩, 木村 英明, 神 美郷, 半澤 秋帆, 柴田 尚美, 米澤 広美, 大島 理加, 藤澤 信, 前田 愼

    日本消化器病学会雑誌   111 ( 臨増大会 )   A875 - A875   2014.9

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  • Doppler ultrasound findings correlate with tissue vascularity and inflammation in surgical pathology specimens from patients with small intestinal Crohn's disease Reviewed

    Tomohiko Sasaki, Tomohiko Sasaki, Tomohiko Sasaki, Reiko Kunisaki, Hiroto Kinoshita, Hideaki Kimura, Teruaki Kodera, Akinori Nozawa, Akiho Hanzawa, Naomi Shibata, Hiromi Yonezawa, Eiji Miyajima, Satoshi Morita, Shoichi Fujii, Kazushi Numata, Katsuaki Tanaka, Masanori Tanaka, Shin Maeda

    BMC Research Notes   7   363   2014.6

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  • Use of color Doppler ultrasonography for evaluating vascularity of small intestinal lesions in Crohn's disease: correlation with endoscopic and surgical macroscopic findings. Reviewed International journal

    Tomohiko Sasaki, Reiko Kunisaki, Hiroto Kinoshita, Hisae Yamamoto, Hideaki Kimura, Akiho Hanzawa, Naomi Shibata, Hiromi Yonezawa, Eiji Miyajima, Kentaro Sakamaki, Kazushi Numata, Katsuaki Tanaka, Shin Maeda

    Scandinavian journal of gastroenterology   49 ( 3 )   295 - 301   2014.3

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    OBJECTIVE. Ultrasonography (US) is a simple, inexpensive and minimally invasive method. We evaluated the vascularity of small intestinal lesions in Crohn's disease using color Doppler US (CD-US) and retrospectively compared them with endoscopic and surgical macroscopic findings. MATERIAL AND METHODS. In order to compare CD-US and endoscopic findings, 108 Crohn's disease patients who underwent examination of the terminal ileum by both colonoscopy and CD-US were included in the study. Vascularity was evaluated in CD-US using a semiquantitative method, the Limberg score. We analyzed correlations between Limberg score and simple endoscopic score for Crohn's disease (SES-CD), an index reflecting endoscopic activity. Scores of SES-CD 3 and higher were defined as endoscopically active. For comparison with surgical macroscopic findings, 22 Crohn's disease patients who received CD-US and subsequent iliectomies were included. Lesions with apparent open ulcers were defined as active, and those without as non-active. These findings were compared with the Limberg score. RESULTS. A substantial positive correlation was observed between Limberg scores and SES-CD (ρ = 0.709 [p < 0.001]). Notably, all 27 cases with a Limberg score of 3 or 4 were classified as endoscopically active. Compared to surgical macroscopic activity, Limberg scores of active lesions were significantly higher than those of non-active lesions (p = 0.005). In particular, all 11 cases with a Limberg score of 3 or 4 were classified as active lesions. CONCLUSION. Vascularity of small intestinal lesions of Crohn's disease evaluated by CD-US with Limberg score is well correlated with endoscopic and surgical macroscopic findings.

    DOI： 10.3109/00365521.2013.871744

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  • The 2nd edition of consensus statements for the diagnosis and management of intestinal Behçet's disease: Indication of anti-TNFα monoclonal antibodies Reviewed

    Tadakazu Hisamatsu, Fumiaki Ueno, Takayuki Matsumoto, Kiyonori Kobayashi, Kazutaka Koganei, Reiko Kunisaki, Fumihito Hirai, Masakazu Nagahori, Mitsunobu Matsushita, Kenji Kobayashi, Mitsumasa Kishimoto, Mitsuhiro Takeno, Masanori Tanaka, Nagamu Inoue, Toshifumi Hibi

    Journal of Gastroenterology   49 ( 1 )   156 - 162   2014.1

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    DOI： 10.1007/s00535-013-0872-4

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  • Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients Reviewed

    Naganuma M, Fujii T, Kunisaki R, Yoshimura N, Takazoe M, Takeuchi Y, Saito E, Nagahori M, Asakura K, Takebayashi T, Watanabe M

    Journal of Crohn's and Colitis   7 ( 4 )   308 - 313   2013

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  • Conception and pregnancy outcome in women with inflammatory bowel disease: A multicentre study from Japan

    Makoto Naganuma, Reiko Kunisaki, Naoki Yoshimura, Masakazu Nagahori, Hisae Yamamoto, Hideaki Kimura, Minako Sako, Takaaki Kawaguchi, Masakazu Takazoe, Shojiro Yamamoto, Toshiyuki Matsui, Toshifumi Hibi, Mamoru Watanabe

    Journal of Crohn's and Colitis   5 ( 4 )   317 - 323   2011.8

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    DOI： 10.1016/j.crohns.2011.02.003

    PubMed

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  • An Open-Label Prospective Randomized Multicenter Study Shows Very Rapid Remission of Ulcerative Colitis by Intensive Granulocyte and Monocyte Adsorptive Apheresis as Compared With Routine Weekly Treatment Reviewed

    Atsushi Sakuraba, Satoshi Motoya, Kenji Watanabe, Masakazu Nishishita, Kazunari Kanke, Toshiyuki Matsui, Yasuo Suzuki, Tadayuki Oshima, Reiko Kunisaki, Takayuki Matsumoto, Hiroyuki Hanai, Ken Fukunaga, Naoki Yoshimura, Toshimi Chiba, Shinsuke Funakoshi, Nobuo Aoyama, Akira Andoh, Hiroshi Nakase, Yohei Mizuta, Ryoichi Suzuki, Taiji Akamatsu, Masahiro Iizuka, Toshifumi Ashida, Toshifumi Hibi

    American Journal of Gastroenterology   104 ( 12 )   2990 - 2995   2009.12

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    Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

    DOI： 10.1038/ajg.2009.453

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    Other Link： http://www.nature.com/articles/ajg2009453

  • Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: Clinical and immunological findings Reviewed

    Kenzaburo Tani, Miyuki Azuma, Yukoh Nakazaki, Naoki Oyaizu, Hidenori Hase, Junko Ohata, Keisuke Takahashi, Maki OiwaMonna, Kisaburo Hanazawa, Yoshiaki Wakumoto, Kouji Kawai, Masayuki Noguchi, Yasushi Soda, Reiko Kunisaki, Kiyoshi Watari, Satoshi Takahashi, Utako Machida, Noriharu Satoh, Arinobu Tojo, Taira Maekawa, Masazumi Eriguchi, Shinji Tomikawa, Hideaki Tahara, Yusuke Inoue, Hiroki Yoshikawa, Yoshitsugu Yamada, Aikichi Iwamoto, Hirofumi Hamada, Naohide Yamashita, Koh Okumura, Tadao Kakizoe, Hideyuki Akaza, Makoto Fujime, Shirley Clift, Dale Ando, Richard Mulligan, Shigetaka Asano

    Molecular Therapy   10 ( 4 )   799 - 816   2004.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ymthe.2004.07.001

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  • Mice lacking a transcriptional corepressor Tob are predisposed to cancer

    Yutaka Yoshida, Takahisa Nakamura, Masato Komoda, Hitoshi Satoh, Toru Suzuki, Junko K. Tsuzuku, Takashi Miyasaka, Eri H. Yoshida, Hisashi Umemori, Reiko K. Kunisaki, Kenzaburo Tani, Shunsuke Ishii, Shigeo Mori, Masami Suganuma, Tetsuo Noda, Tadashi Yamamoto

    Genes &amp; Development   17 ( 10 )   1201 - 1206   2003.5

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    Publishing type：Research paper (scientific journal)   Publisher：Cold Spring Harbor Laboratory  

    tobis a member of antiproliferative family genes. Mice lackingtobare prone to spontaneous formation of tumors. The occurrence rate of diethylnitrosamine-induced liver tumors is higher intob<sup>−/−</sup>mice than in wild-type mice.tob<sup>−/−</sup>p53<sup>−/−</sup>mice show accelerated tumor formation in comparison with single null mice. Expression ofcyclin D1mRNA is increased in the absence of Tob and is reduced by Tob. Tob acts as a transcriptional corepressor and suppresses thecyclin D1promoter activity through an interaction with histone deacetylase. Levels oftobmRNA are often decreased in human cancers, implicatingtobin cancer development.

    DOI： 10.1101/gad.1088003

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Books

  • IBDを日常診療で診る.

    国崎 玲子（ Role： Joint author）

    羊土社  2017 

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  • 炎症性腸疾患(IBD)診療ガイドライン 2016.

    国崎 玲子（ Role： Joint author）

    日本消化器病学会編  2016.11 

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  • IBD診療ビジュアルテキスト

    国崎 玲子（ Role： Joint author）

    羊土社  2016 

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  • クローン病の診療ガイド（第2版）

    国崎 玲子（ Role： Joint author）

    NPO法人日本炎症性腸疾患協会  2016 

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  • 実臨床に役立つIBD内視鏡－診断・モニタリング・サーベイランス－

    国崎 玲子（ Role： Joint author）

    日本メメデイカルセンター  2015 

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MISC

  • Biological Characteristics of Serrated Polyps in Patients with Ulcerative Colitis

    西尾匡史, 西尾匡史, 国崎玲子, 芝田渉, 味岡洋一, 平澤欣吾, 千葉佐和子, 稲山嘉明, 上田渉, 大川清孝, 木村英明, 前田愼

    胃と腸   60 ( 7 )   2025

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  • 腸管ベーチェット病の腸管超音波による活動性スコア作成および検証

    谷口勝城, 谷口勝城, 国崎玲子, 佐藤翔, 海老名俊明, 沼田和司, 沼田和司, 木村英明, 前田愼

    日本消化器病学会雑誌(Web)   122   2025

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  • クローン病併発直腸肛門管腫瘍の特徴と内視鏡診断の問題点

    春山芹奈, 国崎玲子, 西尾匡史, 菅悠紀, 古要優樹, 栗村紀輝, 谷口勝城, 中森義典, 梅沢翔太郎, 小柏剛, 佐々木智彦, 藤井彩子, 本間実, 鳥谷建一郎, 木村英明, 諏訪雄亮, 前田愼

    日本消化器病学会雑誌(Web)   122   2025

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  • クローン病術後吻合部狭窄の現状と対策

    木村英明, 鳥谷建一郎, 本間実, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本外科学会定期学術集会(Web)   125th   2025

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  • 潰瘍性大腸炎に対する大腸全摘術が肝・胆道機能に及ぼす影響

    鳥谷建一郎, 木村英明, 前橋学, 白倉大毅, 栗村紀輝, 春山芹奈, 中森義典, 松林真央, 国崎玲子, 諏訪雄亮, 渡邉純, 熊本宣文, 國崎主税, 遠藤格

    日本消化器外科学会雑誌(Web)   57 ( Supplement2 )   2024

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  • 抗TNFα抗体製剤が奏功した,潰瘍性大腸炎に対する結腸亜全摘後に大量出血と穿孔で発症した小腸多発潰瘍の1例

    鳥谷建一郎, 木村英明, 前橋学, 白倉大毅, 栗村紀輝, 春山芹奈, 中森義典, 松林真央, 国崎玲子, 遠藤格

    日本消化器病学会関東支部例会プログラム・抄録集   379th   2024

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  • 腹腔鏡時代における,Hand-assisted laparoscopic surgery(HALS)大腸全摘術の意義

    木村英明, 鳥谷建一郎, 前橋学, 国崎玲子, 松林真央, 中森義典, 春山芹奈, 栗村紀輝, 白倉大毅, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   57 ( Supplement2 )   2024

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  • 炎症性腸疾患に合併する精神疾患の種類と頻度,病態との関連に関する検討

    三室純生, 国崎玲子, 杉野文音, 畠山雄二朗, 野溝ゆうな, 大中玲奈, 冨永和奏, 久保田真帆, 阿川莉奈, 竹内紀博, 川内真佳, 山口琴美, 笠井志斗, 谷昇達, 市川真優, 菅悠紀, 古要優樹, 栗村紀輝, 春山芹奈, 中森義典, 谷口勝城, 小柏剛, 藤井彩子, 本間実, 鳥谷建一郎, 木村英明, 須田顕, 前田愼

    日本炎症性腸疾患学会学術集会プログラム・抄録集   15th   2024

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  • 当院における日本人IBD合併妊娠に対するチオプリン製剤投与の安全性の検討

    栗村紀輝, 国崎玲子, 白倉大毅, 春山芹奈, 中森義典, 松林真央, 谷口勝城, 梅沢翔太郎, 西尾匡史, 小柏剛, 佐々木智彦, 藤井彩子, 前橋学, 鳥谷建一郎, 木村英明, 青木茂, 前田愼

    日本消化器病学会雑誌(Web)   121   2024

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  • クローン病直腸肛門管癌の内視鏡所見の検討

    春山芹奈, 西尾匡史, 菅悠紀, 古要優樹, 栗村紀輝, 中森義典, 谷口勝城, 梅沢翔太郎, 小柏剛, 佐々木智彦, 藤井彩子, 鳥谷建一郎, 木村英明, 国崎玲子, 前田愼

    Gastroenterological Endoscopy (Web)   66 ( Supplement2 )   2024

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  • 肛門周囲膿瘍を初発症状として発症した若年クローン病患者の肛門病変の長期予後と治療の検討

    杉野文音, 国崎玲子, 中森義典, 栗村紀輝, 白倉大毅, 春山芹奈, 松林真央, 谷口勝城, 鶴雄斗, 鬼澤理沙, 畠山雄二朗, 三室純生, 久保田真帆, 西尾匡史, 佐々木智彦, 梅沢翔太郎, 藤井彩子, 前橋学, 鳥谷建一郎, 木村英明, 前田愼

    日本小児栄養消化器肝臓学会雑誌(Web)   38 ( 1 )   2024

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  • 早期診断を目指したクローン病併発直腸肛門管癌の内視鏡サーベイランス法の検討

    春山芹奈, 国崎玲子, 西尾匡史, 菅悠紀, 古要優樹, 栗村紀輝, 中森義典, 谷口勝城, 梅沢翔太郎, 小柏剛, 佐々木智彦, 藤井彩子, 本間実, 鳥谷建一郎, 木村英明, 諏訪雄亮, 前田愼

    日本炎症性腸疾患学会学術集会プログラム・抄録集   15th   2024

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  • 抗TNFα抗体を投与中の潰瘍性大腸炎患者における高安動脈炎の逆説的発症

    中森義典, 国崎玲子, 菅悠紀, 古要優樹, 栗村紀輝, 春山芹奈, 谷口勝城, 梅沢翔太郎, 小柏剛, 佐々木智彦, 藤井彩子, 鳥谷建一郎, 木村英明, 前田愼

    日本消化器病学会雑誌(Web)   121   2024

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  • 活動性腸管ベーチェット病における腸管超音波所見の特徴と,新規活動性スコア(SUS-BD)の作成

    谷口勝城, 谷口勝城, 国崎玲子, 国崎玲子, 佐藤翔, 海老名俊明, 沼田和司, 沼田和司, 木村英明, 前田愼

    日本消化器病学会雑誌(Web)   121   2024

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  • クローン病の小腸狭窄に対するCAST hoodを用いたバルーン拡張の有用性と安全性

    西尾匡史, 西尾匡史, 国崎玲子, 栗村紀輝, 白倉大毅, 春山芹奈, 中森義典, 松林真央, 木村英明, 平澤欣吾, 前田愼

    日本消化管学会雑誌   8 ( Supplement (CD-ROM) )   2024

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  • Development and Evaluation of a Novel Simple Ultrasound Activity Score for Intestinal Behcet’s Disease

    谷口勝城, 谷口勝城, 国崎玲子, 国崎玲子, 佐藤翔, 木村英明, 沼田和司, 海老名俊明, 前田愼

    超音波医学 Supplement   51   2024

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  • Comparison of preoperative intestinal echocardiographic findings of intestinal Behcet’s disease with surgical pathology findings

    中森義典, 中森義典, 国崎玲子, 国崎玲子, 佐藤翔, 熊谷栄太, 笹原有紀子, 藤井誠志, 木村英明, 沼田和司, 沼田和司, 海老名俊明, 前田愼

    超音波医学 Supplement   51   2024

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  • UC併発腫瘍に対するESDの技術的妥当性の検討

    西尾匡史, 西尾匡史, 国崎玲子, 栗村紀輝, 白倉大毅, 春山芹奈, 中森義典, 松林真央, 小柏剛, 木村英明, 平澤欣吾, 前田愼

    日本炎症性腸疾患学会学術集会プログラム・抄録集   14th   2023

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  • 抗体療法と内視鏡下拡張術時代におけるクローン病腸管手術例の再手術回避の現状と対策

    木村英明, 鳥谷建一郎, 川島淳, 小林圭, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本外科学会定期学術集会(Web)   123rd   2023

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  • 腸管ベーチェット病に対する腸管超音波活動性スコア(SUS-BD)の作成と有用性の検討

    谷口勝城, 谷口勝城, 国崎玲子, 国崎玲子, 佐藤翔, 平井香織, 和泉美郷, 福野よしみ, 田中麻実, 岡崎舞, 栗村紀輝, 栗村紀輝, 白倉大毅, 白倉大毅, 春山芹奈, 春山芹奈, 中森義典, 中森義典, 松林真央, 松林真央, 海老名俊明, 沼田和司, 木村英明, 前田愼

    日本炎症性腸疾患学会学術集会プログラム・抄録集   14th   2023

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  • 当院における日本人IBD合併妊婦に対するチオプリン製剤の安全性

    松林真央, 国崎玲子, 栗村紀輝, 白倉大毅, 春山芹奈, 中森義典, 谷口勝城, 梅沢翔太郎, 西尾匡史, 小柏剛, 佐々木智彦, 藤井彩子, 鳥谷建一郎, 前橋学, 木村英明, 青木茂, 前田愼

    日本炎症性腸疾患学会学術集会プログラム・抄録集   14th   2023

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  • クローン病小腸多発病変に対する手術の現状と対策

    木村英明, 鳥谷建一郎, 小林圭, 川島淳, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   56 ( Supplement1 )   2023

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  • リアルワールドデータからみたクローン病腸管手術例における術後生物学的製剤投与の現状と問題点

    木村英明, 鳥谷建一郎, 前橋学, 栗村紀輝, 白倉大毅, 春山芹奈, 中森義典, 松林真央, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本炎症性腸疾患学会学術集会プログラム・抄録集   14th   2023

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  • 若年IBD患者に対する抗TNF抗体維持療法の継続率および二次無効出現率の検討

    春山芹奈, 国崎玲子, 西田大恭, 栗村紀輝, 白倉大毅, 中森義典, 松林真央, 杉野文音, 三室純生, 大中玲奈, 藤井拓海, 須山隼, 竹内正樹, 久保田真帆, 畠山雄二朗, 冨永和奏, 阿川莉奈, 山下恭平, 平賀晴大, 池上直毅, 鶴雄斗, 西川裕里香, 立野瑞樹, 谷口勝城, 前橋学, 鳥谷建一郎, 木村英明, 前田愼

    日本炎症性腸疾患学会学術集会プログラム・抄録集   14th   2023

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  • 初発症状が肛門部瘻孔および肛門周囲膿瘍で発症した若年クローン病患者の肛門病変の長期予後と治療

    中森義典, 国崎玲子, 白倉大毅, 栗村紀輝, 春山芹奈, 松林真央, 杉野文音, 三室純生, 大中玲奈, 藤井拓海, 須山隼, 竹内正樹, 久保田真帆, 畠山雄二朗, 冨永和奏, 阿川莉奈, 谷口勝城, 梅沢翔太郎, 西尾匡史, 小柏剛, 佐々木智彦, 藤井彩子, 前橋学, 鳥谷建一郎, 木村英明, 前田愼

    日本炎症性腸疾患学会学術集会プログラム・抄録集   14th   2023

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  • 5-ASA製剤またはhalf EDで治療可能なクローン病症例の特徴

    栗村紀輝, 国崎玲子, 白倉大毅, 春山芹奈, 中森義典, 松林真央, 杉野文音, 三室純生, 大中玲奈, 藤井拓海, 須山隼, 竹内正樹, 久保田真帆, 畠山雄二朗, 冨永和奏, 阿川莉奈, 谷口勝城, 梅沢翔太郎, 西尾匡史, 小柏剛, 佐々木智彦, 藤井彩子, 前橋学, 鳥谷建一郎, 木村英明, 前田愼

    日本炎症性腸疾患学会学術集会プログラム・抄録集   14th   2023

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  • クローン病の母の短腸に起因したビタミンK吸収障害が原因と思われる新生児小脳出血の一例

    白倉大毅, 国崎玲子, 栗村紀輝, 春山芹奈, 中森義典, 松林真央, 谷口勝城, 西尾匡史, 小柏剛, 佐々木智彦, 梅沢翔太郎, 藤井彩子, 前橋学, 鳥谷建一郎, 木村英明, 池永知穂, 内良介, 青木茂, 前田愼

    日本炎症性腸疾患学会学術集会プログラム・抄録集   14th   2023

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  • 腸管ベーチェット病の術前腸管エコー所見と手術病理所見との比較

    佐藤翔, 国崎玲子, 谷口勝城, 熊谷栄太, 笹原有紀子, 平井香織, 福野よしみ, 田中麻実, 栗村紀輝, 白倉大毅, 春山芹奈, 中森義典, 松林真央, 西川裕里香, 前橋学, 鳥谷建一郎, 木村英明, 海老名俊明, 稲山嘉明, 藤井誠志, 沼田和司, 前田愼

    日本炎症性腸疾患学会学術集会プログラム・抄録集   14th   2023

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  • ウステキヌマブで改善がえられたIL-10受容体遺伝子異常症疑い例

    西田大恭, 国崎玲子, 東大輔, 角田翔太郎, 谷口勝城, 藤井紘大, 木村英明, 竹内一朗, 新井勝大, 明本由衣, 前田愼

    日本小児栄養消化器肝臓学会雑誌   36 ( 1 )   2022

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  • 炎症性腸疾患の現状

    木村英明, 荒木謙太郎, 布施匡啓, 鳥谷建一郎, 国崎玲子, 遠藤格

    日本腹部救急医学会雑誌   42 ( 2 )   2022

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  • 手術検体で漿膜炎を証明した家族性地中海熱遺伝子関連腸炎疑いの一例

    東大輔, 谷口勝城, 角田翔太郎, 藤井絋大, 西田大恭, 豊田純哉, 荒木謙太郎, 渋井俊祐, 中森義典, 池田礼, 斑目明, 西尾匡史, 松林真央, 小柏剛, 藤井彩子, 木村英明, 国崎玲子, 前田晃樹, 稲山嘉明, 前田愼

    日本消化器病学会関東支部例会プログラム・抄録集   370th   2022

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  • クローン病小腸病変に対する手術例の検討

    木村英明, 荒木謙太郎, 布施匡啓, 鳥谷建一郎, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   55 ( Supplement2 )   2022

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  • クローン病腸管手術例の現状と課題

    木村英明, 荒木謙太郎, 大坊侑, 鳥谷建一郎, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本外科学会定期学術集会(Web)   122nd   2022

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  • A case of Crohn’s disease resembling phlegmonous colitis occurred by abscess in the pelvis

    古澤享子, 古澤享子, 国崎玲子, 国崎玲子, 厚坂励生, 厚坂励生, 谷口勝城, 谷口勝城, 藤井紘大, 西田大恭, 中森義典, 中森義典, 池田礼, 池田礼, 西尾匡史, 西尾匡史, 松林真央, 松林真央, 小柏剛, 小柏剛, 藤井彩子, 木村英明, 前田晃樹, 稲山嘉明, 前田愼

    Progress of Digestive Endoscopy   100 ( 1 )   2022

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  • 回腸クローン病変の膿瘍波及により直腸の多発結節隆起を呈した一例

    古澤享子, 厚坂励生, 谷口勝城, 藤井紘大, 西田大恭, 大坊侑, 荒木謙太郎, 渋井俊祐, 中森義典, 池田礼, 班目明, 西尾匡史, 松林真央, 小柏剛, 藤井彩子, 芝田渉, 木村英明, 国崎玲子, 前田晃樹, 稲山嘉明, 前田愼

    Progress of Digestive Endoscopy   100 ( Supplement )   2021

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  • クローン病手術例における術後内科治療の現状と課題

    木村英明, 荒木謙太郎, 大坊侑, 藤井紘大, 谷口勝城, 厚坂励生, 古澤享子, 西田大恭, 国崎玲子, 國崎主税, 遠藤格

    消化器疾患病態治療研究会プログラム・抄録集   30th   2021

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  • 消化器外科における高齢者手術-各施設の工夫と留意点 高齢者に対する炎症性腸疾患手術の工夫と留意点

    木村英明, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    手術   75 ( 10 )   2021

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  • Medical Square File No.234 疾患のある患者の妊娠・出産と治療 炎症性腸疾患

    西田大恭, 国崎玲子, 木村英明, 青木茂

    新薬と臨床   70 ( 8 )   2021

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  • Crohn病術後再手術例の特徴と問題点

    木村英明, 鳥谷建太郎, くわ原寛, 中森義典, 池田礼, 班目明, 平山敦大, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化管学会雑誌   4 ( Supplement )   2020

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  • 難治性炎症性腸管障害に関する調査研究 腸管型ベーチェット診療ガイドライン作成プロジェクト

    久松理一, 久松理一, 井上詠, 小林清典, 長堀正和, 渡辺憲治, 谷田諭史, 小金井一隆, 国崎玲子, 新井勝大, 内野基, 小林拓, 岳野光洋, 上野文昭, 松本主之, 鈴木康夫

    難治性炎症性腸管障害に関する調査研究 令和元年度 総括・分担研究報告書(Web)   2020

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  • 当院における抗TNF抗体無効・不耐クローン病に対するウステキヌマブの治療成績

    中森義典, 中森義典, 池田礼, 班目明, 平山敦大, 藤井彩子, 下山義博, 鳥谷建一郎, 桑原寛, 前田愼, 木村英明, 国崎玲子

    日本消化器病学会雑誌(Web)   117   2020

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  • ベーチェット病に関する調査研究 腸管ベーチェット病診療ガイドライン作成

    久松理一, 井上詠, 長堀正和, 小林清典, 渡辺憲治, 谷田諭史, 小金井一隆, 国崎玲子, 新井勝大, 内野基, 小林拓, 岳野光洋, 上野文昭, 松本主之, 鈴木康夫

    ベーチェット病に関する調査研究 令和元年度 研究報告書(Web)   2020

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  • Graft-versus-host disease

    小柏剛, 国崎玲子, 木村英明

    消化器内視鏡   32   2020

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  • 潰瘍性大腸炎に対する回腸嚢肛門管吻合術

    木村英明, 鳥谷建一郎, 桑原寛, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本外科学会定期学術集会(Web)   120th   2020

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  • 小児潰瘍性大腸炎治療指針(2019年)

    虻川 大樹, 青松 友槻, 井上 幹大, 岩間 達, 熊谷 秀規, 清水 泰岳, 神保 圭佑, 南部 隆亮, 水落 建輝, 内田 恵一, 国崎 玲子, 石毛 崇, 福岡 智哉, 新井 勝大, 清水 俊明, 田尻 仁, 日本小児栄養消化器肝臓学会・日本小児IBD研究会小児IBD治療指針2019改訂ワーキンググループ

    日本小児栄養消化器肝臓学会雑誌   33 ( 2 )   110 - 127   2019.12

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  • 小児クローン病治療指針(2019年)

    新井 勝大, 工藤 孝広, 熊谷 秀規, 齋藤 武, 清水 泰岳, 高橋 美智子, 立花 奈緒, 南部 隆亮, 内田 恵一, 国崎 玲子, 石毛 崇, 福岡 智哉, 虻川 大樹, 清水 俊明, 田尻 仁, 日本小児栄養消化器肝臓学会・日本小児IBD研究会小児IBD治療指針2019改訂ワーキンググループ

    日本小児栄養消化器肝臓学会雑誌   33 ( 2 )   90 - 109   2019.12

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  • 日本小児炎症性腸疾患レジストリを用いた小児期発症クローン病に対する栄養療法の使用実態の解析

    石毛 崇, 村越 孝次, 国崎 玲子, 萩原 真一郎, 清水 泰岳, 齋藤 武, 中山 佳子, 柳 忠宏, 井上 幹大, 熊谷 秀規, 岩間 達, 望月 貴博, 田尻 仁, 平野 友梨, 新井 勝大

    日本小児栄養消化器肝臓学会雑誌   33 ( Suppl. )   126 - 126   2019.10

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  • 小児期発症クローン病における栄養療法による維持療法の有用性・維持効果の検討 日本小児炎症性腸疾患レジストリ研究2019

    石毛 崇, 村越 孝次, 国崎 玲子, 萩原 真一郎, 清水 泰岳, 齋藤 武, 中山 佳子, 柳 忠宏, 井上 幹大, 熊谷 秀規, 岩間 達, 望月 貴博, 田尻 仁, 平野 友梨, 新井 勝大

    日本小児栄養消化器肝臓学会雑誌   33 ( 1 )   45 - 46   2019.4

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  • 小児期発症クローン病における栄養療法による維持療法の有用性・維持効果の検討 日本小児炎症性腸疾患レジストリ研究2019

    石毛 崇, 村越 孝次, 国崎 玲子, 萩原 真一郎, 清水 泰岳, 齋藤 武, 中山 佳子, 柳 忠宏, 井上 幹大, 熊谷 秀規, 岩間 達, 望月 貴博, 田尻 仁, 平野 友梨, 新井 勝大

    日本小児栄養消化器肝臓学会雑誌   33 ( 1 )   45 - 46   2019.4

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  • 食道の炎症を視る その他・非特異性 IBDに合併した食道潰瘍-Behcet病を含めて-

    平山敦大, 中森義典, 池田礼, 班目明, 藤井彩子, 下山義博, 木村英明, 国崎玲子

    消化器内視鏡   31 ( 8 )   2019

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  • 難治性炎症性腸管障害に関する調査研究 家族性地中海熱遺伝子関連腸炎の診断法の確立並びに病態解明

    仲瀬裕志, 飯田智也, 平山大輔, 櫻井晃弘, 久松理一, 松本主之, 江崎幹宏, 国崎玲子, 松浦稔, 大宮美香, 荒木寛司, 渡辺憲治, 田中浩紀, 小林拓, 日比紀文, 竹内健, 鈴木康夫

    難治性炎症性腸管障害に関する調査研究 平成30年度 総括・分担研究報告書(Web)   2019

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  • ベーチェット病に関する調査研究 腸管型ベーチェット診療ガイドライン作成プロジェクト

    久松理一, 井上詠, 長堀正和, 小林清典, 渡辺憲治, 谷田諭史, 小金井一隆, 国崎玲子, 新井勝大, 内野基, 小林拓, 岳野光洋, 上野文昭, 松本主之, 鈴木康夫

    ベーチェット病に関する調査研究 平成30年度 総括・分担研究報告書(Web)   2019

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  • 難治性炎症性腸管障害に関する調査研究 腸管型ベーチェット診療ガイドライン作成プロジェクト

    久松理一, 井上詠, 小林清典, 長堀正和, 渡辺憲治, 谷田諭史, 小金井一隆, 国崎玲子, 新井勝大, 内野基, 小林拓, 岳野光洋, 上野文昭, 松本主之, 鈴木康夫

    難治性炎症性腸管障害に関する調査研究 平成30年度 総括・分担研究報告書(Web)   2019

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  • 回腸嚢肛門管吻合術の大腸粘膜残存に対するBody mass indexの影響

    木村英明, 千田圭悟, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   52 ( Supplement2 )   2019

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  • 当院における日本人IBD合併妊婦に対するチオプリン製剤投与の安全性

    池田礼, 中森義典, 斑目明, 平山敦太, 藤井彩子, 下山義博, 木村英明, 国崎玲子, 前田慎, 青木茂, 関和男

    日本消化器病学会雑誌(Web)   116   2019

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  • 潰瘍性大腸炎に合併した大腸腫瘍の現状と対策

    田村裕子, 木村英明, 国崎玲子, 大田貢由, 國崎主税, 徳久元彦, 市川靖史, 石部敦士, 遠藤格

    日本外科学会定期学術集会(Web)   119th   2019

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  • Crohn病の吻合法に求められるものは何か?

    木村英明, 千田圭悟, 橋本悠, 池田礼, 小柏剛, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   52 ( Supplement1 )   2019

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  • 生物学的製剤時代におけるクローン病腸管病変手術の長期予後

    木村英明, 田村裕子, 三井智広, 橋本悠, 池田礼, 小柏剛, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本外科学会定期学術集会(Web)   119th   2019

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  • よく使う日常治療薬の正しい使い方 潰瘍性大腸炎治療薬の正しい使い方

    中森義典, 国崎玲子, 木村英明

    レジデントノート   21 ( 10 )   2019

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  • 消化管超音波所見から確診に至った,地中海熱類縁腸炎(MEFV遺伝子関連腸炎)の一例

    柴田尚美, 福野よしみ, 和泉美郷, 平井香織, 中森義典, 池田礼, 木村英明, 国崎玲子

    超音波医学   46 ( Supplement (CD-ROM) )   2019

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  • 日本小児炎症性腸疾患レジストリ研究報告2018 手術症例の検討

    齋藤 武, 井上 幹大, 国崎 玲子, 南部 隆亮, 村越 孝次, 角田 文彦, 石毛 崇, 田尻 仁, 水落 建輝, 加藤 沢子, 吉年 俊文, 岩田 直美, 吉田 英生, 内田 恵一, 清水 泰岳, 平野 友梨, 新井 勝大

    日本小児栄養消化器肝臓学会雑誌   32 ( 1 )   45 - 45   2018.4

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  • 重症潰瘍性大腸炎治療における内科と外科の連携

    木村英明, 田村裕美, 三井智広, 橋本悠, 池田礼, 小柏剛, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本大腸肛門病学会雑誌(Web)   71 ( 9 )   2018

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  • Body mass index高値は回腸嚢肛門管吻合術における残存大腸粘膜増加の危険因子である

    木村英明, 高橋直行, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   51 ( Supplement1 )   2018

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  • クローン病腸管病変手術の現況と展望

    木村英明, 高橋弘毅, 橋本悠, 西尾匡史, 大竹はるか, 小柏剛, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本外科学会定期学術集会(Web)   118th   2018

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  • 小児潰瘍性大腸炎手術例の検討

    高橋弘毅, 木村英明, 国崎玲子, 遠藤格

    日本外科学会定期学術集会(Web)   118th   2018

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  • 難治性炎症性腸管障害に関する調査研究 家族性地中海熱遺伝子関連腸炎の診断法の確立並びに病態解明

    仲瀬裕志, 飯田智也, 平山大輔, 櫻井晃弘, 久松理一, 松本主之, 江崎幹宏, 国崎玲子, 松浦稔, 大宮美香, 荒木寛司, 渡辺憲治, 本谷聡, 小林拓, 日比紀文, 竹内健, 鈴木康夫

    難治性炎症性腸管障害に関する調査研究 平成29年度 総括・分担研究報告書   2018

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  • 腸管型ベーチェット診療ガイドライン作成プロジェクト

    久松理一, 井上詠, 長堀正和, 小林清典, 渡辺憲治, 谷田諭史, 小金井一隆, 国崎玲子, 新井勝大, 小林拓, 岳野光洋, 上野文昭, 松本主之, 鈴木康夫

    ベーチェット病に関する調査研究 平成29年度 総括・分担研究報告書(Web)   2018

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  • 潰瘍性大腸炎に対する新規体外式US活動性スコアの作成

    橋本悠, 久米菜緒, 石井義人, 金村知輝, 芳賀暁, 高橋弘毅, 西尾匡史, 大竹はるか, 小柏剛, 和泉美郷, 半澤秋帆, 米澤広美, 三枝祐輔, 木村英明, 国崎玲子

    日本消化管学会雑誌   2 ( Supplement )   2018

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  • 「小児期発症クローン病と診断され,造血幹細胞移植が施行されたX連鎖リンパ増殖症候群2型(XIAP欠損症)症例の治療経過」

    国崎玲子, 橋本悠, 西尾匡史, 大竹はるか, 小柏剛, 佐々木智彦, 村田依子, 高橋弘毅, 高橋直行, 木村英明, 田中真理, 小野真太郎, 柳町昌克, 金兼弘和

    日本小児IBD研究会プログラム・抄録集   18th   2018

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  • 難治性炎症性腸管障害に関する調査研究 腸管型ベーチェット診療ガイドライン作成プロジェクト

    久松理一, 井上詠, 小林清典, 長堀正和, 渡辺憲治, 谷田諭史, 小金井一隆, 国崎玲子, 新井勝大, 小林拓, 岳野光洋, 上野文昭, 松本主之, 鈴木康夫

    難治性炎症性腸管障害に関する調査研究 平成29年度 総括・分担研究報告書   2018

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  • 炎症性腸疾患のがん化 クローン病に合併した肛門部癌の診断と治療

    木村英明, 国崎玲子, 小金井一隆, 杉田昭, 遠藤格

    日本臨床   76   2018

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  • Efficacy of intravenous cyclosporine in fulminant steroid-refractory ulcerative colitis with massive bleeding: a retrospective, observational study

    T. Ogashiwa, M. Nishio, H. Otake, E. Inoue, H. Kimura, R. Kunisaki

    JOURNAL OF CROHNS & COLITIS   11   S248 - S249   2017.2

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  • ベーチェット病に関する調査研究 腸管型ベーチェット診療ガイドライン作成プロジェクト

    久松理一, 井上詠, 長堀正和, 小林清典, 渡辺憲治, 谷田諭史, 小金井一隆, 国崎玲子, 新井勝大, 小林拓, 岳野光洋, 上野文昭, 松本主之, 鈴木康夫

    ベーチェット病に関する調査研究 平成28年度 総括・分担研究報告書(Web)   2017

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  • 当院で経験した地中海熱類縁腸炎(MEFV腸炎)の臨床的・画像的特徴の検討

    小柏剛, 橋本悠, 西尾匡史, 大竹はるか, 松林真央, 佐々木智彦, 中戸川満智子, 木村英明, 国崎玲子

    Gastroenterological Endoscopy (Web)   59 ( Supplement2 )   2017

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  • 難治性炎症性腸管障害に関する調査研究 腸管型ベーチェット診療ガイドライン作成プロジェクト

    久松理一, 井上詠, 小林清典, 長堀正和, 渡辺憲治, 谷田諭史, 小金井一隆, 国崎玲子, 新井勝大, 小林拓, 岳野光洋, 上野文昭, 松本主之, 鈴木康夫

    難治性炎症性腸管障害に関する調査研究 平成28年度 総括・分担研究報告書(Web)   2017

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  • 難治性炎症性腸管障害に関する調査研究 炎症性腸疾患病態におけるMEFV遺伝子変異の意義

    本澤有介, 仲瀬裕志, 小野寺馨, 本谷聡, 田中浩紀, 松浦稔, 豊永貴彦, 小林拓, 久松理一, 国崎玲子, 江崎幹宏, 竹内健, 石黒陽, 松本主之, 鈴木康夫, 日比紀文

    難治性炎症性腸管障害に関する調査研究 平成28年度 総括・分担研究報告書(Web)   2017

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  • クローン病術後再手術例の現状と対策

    木村英明, 井上英美, 小柏剛, 大竹はるか, 西尾匡史, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化器病学会大会(Web)   59th   2017

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  • 当院におけるIBD合併妊娠に対する抗TNFα抗体製剤投与の安全性の検討

    大竹はるか, 橋本悠, 西尾匡史, 小柏剛, 松林真央, 佐々木智彦, 木村英明, 国崎玲子, 笠井絢子, 青木茂, 関和男

    日本消化器病学会大会(Web)   59th   2017

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  • 潰瘍性大腸炎・クローン病手術のすべて I.潰瘍性大腸炎 6)回腸嚢肛門管吻合術(IACA)

    木村英明, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    手術   71 ( 7 )   2017

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  • 関節リウマチに対してアバタセプト投与中に潰瘍性大腸炎を発症した1例

    中積広貴, 橋本悠, 小柏剛, 高橋弘毅, 西尾匡史, 大竹はるか, 佐々木智彦, 木村英明, 国崎玲子, 山前正臣

    日本内科学会関東支部関東地方会   634th   2017

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  • 潰瘍性大腸炎の回腸嚢肛門管吻合術における残存大腸粘膜増加の危険因子

    木村英明, 井上英美, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   50 ( Supplement1 )   2017

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  • 小児クローン病に対する栄養療法による寛解導入および寛解維持効果の検討

    小柏剛, 西尾匡史, 大竹はるか, 松林真央, 木村英明, 国崎玲子

    日本静脈経腸栄養学会雑誌   32 ( supplement )   2017

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  • 潰瘍性大腸炎におけるserrated neoplasia pathwayを介する新規腫瘍発生経路の検討

    西尾匡史, 芝田渉, 芝田渉, 大竹はるか, 小柏剛, 上田渉, 大川清孝, 平澤欣吾, 木村英明, 国崎玲子, 味岡洋一, 前田愼

    日本消化器病学会大会(Web)   59th   2017

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  • IBD上部消化管病変に対する経口5-アミノサリチル酸製剤粉砕投与の有用性

    大竹はるか, 橋本悠, 西尾匡史, 小柏剛, 石井義人, 金村知輝, 木村英明, 国崎玲子

    日本消化器病学会大会(Web)   59th   2017

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  • 大腸全摘回腸嚢肛門(管)吻合後に広範な小腸炎を発症した潰瘍性大腸炎の症例の検討

    井上英美, 木村英明, 大竹はるか, 西尾匡史, 小柏剛, 国崎玲子, 遠藤格

    日本外科学会定期学術集会(Web)   117th   2017

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  • 再手術例からみたクローン病手術後の問題点

    木村英明, 井上英美, 小柏剛, 大竹はるか, 西尾匡史, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化管学会総会学術集会プログラム・抄録集   13th   2017

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  • Current practices in guidance, management and nursing of pregnant women or women wishing to become pregnant who have inflammatory bowel diseases

    国崎玲子, 大竹はるか, 西尾匡史, 小柏剛, 木村英明, 中川まどか, 中川まどか, 返田紀子, 返田紀子, 青木茂, 関和男

    Intestine   21 ( 2 )   2017

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  • 腸炎まるわかり〔感染性腸炎〕サイトメガロウイルス腸炎

    小柏剛, 西尾匡史, 大竹はるか, 松林真央, 佐々木智彦, 中戸川満智子, 井上英美, 木村英明, 国崎玲子

    消化器内視鏡   29 ( 1 )   2017

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  • 難治性炎症性腸管障害に関する調査研究 炎症性腸疾患診療ガイドラインの改訂

    上野文昭, 渡邉聡明, 松井敏幸, 渡辺守, 井上詠, 小俣富美雄, 加藤順, 金井隆典, 国崎玲子, 小金井一隆, 小林清典, 小林健二, 猿田雅之, 高橋賢一, 仲瀬裕志, 長堀正和, 野口善令, 平井郁仁, 本谷聡, 渡辺憲治, 小林拓, 松岡克善

    難治性炎症性腸管障害に関する調査研究 平成28年度 総括・分担研究報告書(Web)   2017

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  • 日本小児炎症性腸疾患レジストリ研究2015

    新井 勝大, 国崎 玲子, 村越 孝次, 角田 文彦, 萩原 真一郎, 柳 忠宏, 石毛 崇, 清水 俊明, 加藤 沢子, 齋藤 武, 井上 幹大, 熊谷 秀規, 青松 友槻, 西亦 繁雄, 岩間 達, 田尻 仁, 岩田 直美, 望月 貴博, 柏原 俊彦, 野口 篤子, 清水 泰岳, 平野 友梨, 藤原 武男, 日本小児炎症性腸疾患レジストリ研究グループ

    日本小児栄養消化器肝臓学会雑誌   30 ( 1 )   31 - 31   2016.4

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  • Transabdominal ultrasonography to assess intestinal wall thickness and vascularity appears to predict therapeutic effects of steroid treatment in moderate-to-severe ulcerative colitis patients

    T. Ogashiwa, M. Murakami, S. Tsuda, M. Nishio, Y. Kogure, K. Kasahara, K. Hirai, Y. Fukuno, M. Jin, A. Hanzawa, H. Yonezawa, K. Numata, H. Kimura, R. Kunisaki

    JOURNAL OF CROHNS & COLITIS   10   S318 - S318   2016.3

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  • 母性内科の最前線 周産期における炎症性腸疾患(IBD)の管理

    国崎玲子, 木村英明, 関和男

    医学のあゆみ   256 ( 3 )   2016

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  • IBD治療のcritical point-私ならこうする 8 クローン病-手術適応と手術後の治療方針(1)外科医が術後フォローする立場から

    木村英明, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    臨床消化器内科   31 ( 6 )   2016

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  • HALSの意義とテクニック 3.HALSによる小腸・大腸の手術 5)潰瘍性大腸炎手術におけるHALSの応用

    木村英明, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    外科   78 ( 9 )   2016

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  • クローン病手術後における再手術回避のための治療方針

    木村英明, 笠原康平, 村上麻友, 西尾匡史, 津田早耶, 小柏剛, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   49 ( Supplement2 )   2016

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  • クローン病術後吻合部再発診断における体外式超音波検査の有用性

    村上麻友, 国崎玲子, 木村英明, 松田玲圭, 金村知輝, 芳賀暁, 沼田和司, 坂巻顕太郎

    日本消化器病学会雑誌   113   2016

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  • クローン病における肉眼的所見と水浸法超音波検査による壁厚の相関に関する検討

    小柏剛, 谷口勝城, 沼田和司, 西尾匡史, 大竹はるか, 木村英明, 国崎玲子, 前田愼

    日本消化器病学会大会(Web)   58th   2016

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  • クローン病の診断で施行された小腸内視鏡検査が診断の契機となった,地中海熱類縁腸炎(MEFV関連腸炎)疑いの一例

    小宮孝章, 小柏剛, 西尾匡史, 大竹はるか, 松林真央, 佐々木智彦, 中戸川満智子, 井上英美, 木村英明, 国崎玲子

    Progress of Digestive Endoscopy   90 ( Supplement )   2016

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  • 生物学的製剤時代におけるクローン病術後再手術例の再燃形式と問題点

    木村英明, 笠原康平, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   49 ( Supplement1 )   2016

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  • 小児潰瘍性大腸炎に対する外科治療の有用性

    笠原康平, 木村英明, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   49 ( Supplement1 )   2016

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  • Transabdominal ultrasonography for ulcerative colitis

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    Intestine   20 ( 4 )   2016

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  • 広範病変に経腸栄養療法単独での寛解導入・維持により病変の改善が得られ,長期寛解を維持している小児CD症例~小児と成人では栄養療法への反応性は異なるのか?~

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    日本小児IBD研究会プログラム・抄録集   16th   2016

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  • 7年間再発性下痢,発熱嘔吐を繰り返し,ランブル鞭毛症の確診に至った1例

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    Progress of Digestive Endoscopy   90 ( Supplement )   2016

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  • 難治性炎症性腸管障害に関する調査研究 炎症性腸疾患診療ガイドラインの改訂

    上野文昭, 渡邉聡明, 松井敏幸, 渡辺守, 井上詠, 小俣富美雄, 加藤順, 金井隆典, 国崎玲子, 小金井一隆, 小林清典, 小林健二, 猿田雅之, 高橋賢一, 仲瀬裕志, 長堀正和, 野口善令, 平井郁仁, 本谷聡, 渡辺憲治

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  • 当院における潰瘍性大腸炎術後妊娠出産例の特徴

    木村英明, 小暮悠, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本外科学会定期学術集会(Web)   116th   2016

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  • 潰瘍性大腸炎に併発した大腸鋸歯状病変の検討

    NISHIO TADASHI, KUNISAKI REIKO, HIRASAWA KINGO, MURAKAMI MAYU, TSUDA SAYA, OGASHIWA TSUYOSHI, KO RENKO, KIMURA HIDEAKI, AJIOKA YOICHI, MAEDA SHIN

    Gastroenterol Endosc   57 ( Supplement 2 )   2177   2015.9

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  • Narrow Brand Imaging(NBI)拡大観察は腸管急性GVHDの内視鏡診断能を有意に向上させる

    OGASHIWA TSUYOSHI, KUNISAKI REIKO, KIMURA HIDEAKI

    Gastroenterol Endosc   57 ( Supplement 1 )   670   2015.4

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  • IBDの食道病変の検討

    TSUDA SAYA, KUNISAKI REIKO, KIMURA HIDEAKI

    Gastroenterol Endosc   57 ( Supplement 1 )   711   2015.4

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  • 日本小児炎症性腸疾患レジストリ研究報告2014

    新井 勝大, 国崎 玲子, 角田 文彦, 村越 孝次, 鍵本 聖一, 柳 忠宏, 石毛 崇, 清水 俊明, 岩間 達, 井上 幹大, 中山 佳子, 青松 友規, 望月 貴博, 河島 尚志, 熊谷 秀規, 田尻 仁, 岩田 直美, 清水 泰岳

    日本小児栄養消化器肝臓学会雑誌   29 ( 1 )   19 - 20   2015.4

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  • Efficacy and Nephrotoxicity of Long-term Maintenance Therapy with Tacrolimus in Patients with Ulcerative Colitis

    S. Tsuda, R. Kunisaki, T. Ogashiwa, H. Yasuhara, R. Koh, S. Tsunoda, S. Yamamoto, N. Kawashima, R. Kubota, K. Yazawa, K. Goto, H. Kimura, S. Maeda

    JOURNAL OF CROHNS & COLITIS   9   S379 - S379   2015.2

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  • 潰瘍性大腸炎の最適治療と臨床的問題への対策 潰瘍性大腸炎の妊娠・出産-治療の問題点とその対策-

    村上麻友, 国崎玲子, 津田早耶, 西尾匡史, 小柏剛, 小暮悠, 木村英明

    消化器の臨床   18 ( 4 )   2015

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  • 当院のクローン病に対するアダリムマブの治療経験

    小柏剛, 津田早耶, 安原ひさ恵, 高蓮浩, 国崎玲子, 木村英明, 前田愼

    日本消化管学会総会学術集会プログラム・抄録集   11th   2015

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  • 潰瘍性大腸炎術後妊娠出産例の検討

    矢澤慶一, 木村英明, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 井上英美, 遠藤格

    日本外科学会定期学術集会(Web)   115th   2015

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  • Crohn病結腸十二指腸瘻に対する手術術式

    木村英明, 矢澤慶一, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 井上英美, 遠藤格

    日本外科学会定期学術集会(Web)   115th   2015

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  • 潰瘍性大腸炎関連大腸癌の検討

    後藤晃紀, 木村英明, 津田早耶, 小柏剛, 安原ひさ惠, 高蓮浩, 国崎玲子, 遠藤格

    日本消化器外科学会雑誌(Web)   48 ( Supplement1 )   2015

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  • Surgical timing for severe ulcerative colitis

    木村英明, 後藤晃紀, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 井上英美, 遠藤格

    日本消化器外科学会雑誌(Web)   48 ( Supplement1 )   2015

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  • 超音波ならではを集める!~第36回超音波ドプラ研究会臨床研究集~超音波検査の優位性(CTやMRIなどの他画像と比較して)クローン病に対するDoppler超音波検査とCTの病変検出能の比較

    佐々木智彦, 佐々木智彦, 国崎玲子, 木村英明, 半澤秋帆, 柴田尚美, 宮島栄治, 沼田和司, 田中克明, 森なお子, 市川珠紀, 前田愼

    Rad Fan   13 ( 5 )   2015

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  • 自己免疫疾患 第3回 炎症性腸疾患の病態と治療

    木村英明, 国崎玲子, 遠藤格

    アニムス   20 ( 1 )   2015

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  • 体外式超音波検査による活動期潰瘍性大腸炎の治療効果予測の検討

    小柏剛, 国崎玲子, 村上麻友, 西尾匡史, 津田早耶, 小暮悠, 木村英明, 平井香織, 福野よしみ, 神美郷, 半澤秋帆, 米澤広美, 芳賀暁, 金村知輝, 石井義人, 窪田硫富人, 谷口勝城, 角田翔太郎, 沼田和司

    日本大腸検査学会総会プログラム・抄録集   33rd   2015

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  • 難治性炎症性腸管障害に関する調査研究 炎症性腸疾患診療ガイドラインの改訂

    上野文昭, 渡邉聡明, 松井敏幸, 渡辺守, 井上詠, 小俣富美雄, 加藤順, 国崎玲子, 小金井一隆, 小林清典, 小林健二, 猿田雅之, 仲瀬裕志, 長堀正和, 平井郁仁, 本谷聡, 野口善令

    難治性炎症性腸管障害に関する調査研究 平成26年度 総括・分担研究報告書   2015

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  • Esophageal Involvement Associated with Inflammatory Bowel Disease

    安原ひさ恵, 国崎玲子, 津田早耶, 小柏剛, KOH Ryonho, 木村英明

    胃と腸   50 ( 2 )   2015

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  • 日本小児炎症性腸疾患レジストリ研究報告2013

    新井 勝大, 国崎 玲子, 虻川 大樹, 石毛 崇, 岩間 達, 望月 貴博, 井上 幹大, 清水 泰岳, 平野 友梨, 船山 理恵

    日本小児栄養消化器肝臓学会雑誌   28 ( 2 )   119 - 119   2014.12

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    Language：Japanese   Publisher：日本小児栄養消化器肝臓学会  

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  • 小児期発症クローン病と診断されていたX連鎖リンパ増殖症候群2型(XLP-type2)の2例

    国崎 玲子, 石毛 崇, 山本 壽恵, 池田 良輔, 松林 真央, 木下 裕人, 佐々木 智彦, 原田 真吾, 井上 英美, 木村 英明, 原 拓麿, 森 雅亮, 杉田 昭, 齋藤 武, 吉田 英生, 田中 正則, 八角 高裕, 西小森 隆太, 金兼 弘和, 前田 愼

    日本小児栄養消化器肝臓学会雑誌   28 ( 1 )   39 - 40   2014.4

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    Language：Japanese   Publisher：日本小児栄養消化器肝臓学会  

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  • 病態と周術期合併症からみた重症潰瘍性大腸炎に対する外科治療のタイミング

    木村英明, 小笠原康夫, 田鍾寛, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 井上英美, 遠藤格

    日本消化器外科学会雑誌(Web)   47 ( Supplement1 )   2014

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  • ここまで来た,炎症性腸疾患の新展開 炎症性腸疾患と妊娠

    KOH Ryonho, 国崎玲子, 稲垣尚子, 佐々木智彦, 小笠原康夫, 木村英明, 倉澤健太郎, 前田愼

    成人病と生活習慣病   44 ( 3 )   2014

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  • 炎症性腸疾患の画像診断modality III 体外式超音波検査(エコー)-炎症性腸疾患診療における体外式腹部超音波検査の有用性

    谷口勝城, 国崎玲子, 木村英明, 半澤秋帆, 神美郷, 柴田尚美, 米澤広美, 沼田和司, 前田愼

    Intestine   18 ( 2 )   2014

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  • 栄養療法に対するクローン病患者/家族の意識と問題点~自作アンケート調査から~

    稲垣尚子, 清水香織, 松岡明子, 守屋隆, 牛島大介, 小倉千沙, 山本壽恵, 木村英明, 国崎玲子, 前田愼

    静脈経腸栄養   29 ( 1 )   2014

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  • クローン病腸管手術後における生物学的製剤の再手術予防効果

    木村英明, 国崎玲子, 遠藤格

    Gastroenterological Endoscopy   56 ( Supplement 2 )   2014

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  • 当科で経験したアメーバ性大腸炎の検討

    安原ひさ恵, 国崎玲子, 津田早耶, 小柏剛, 高連浩, 矢澤慶一, 木村英明, 前田愼

    日本大腸こう門病学会雑誌   67 ( 9 )   2014

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  • 難治潰瘍性大腸炎に対するTacrolimusによる長期治療成績-手術回避率の検討-

    国崎玲子, 木村英明, 前田愼

    Gastroenterological Endoscopy   56 ( Supplement 2 )   2014

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  • 潰瘍性大腸炎外科治療に対する新規薬物療法の影響

    木村英明, 田鍾寛, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 井上英美, 遠藤格

    日本外科学会雑誌   115   2014

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  • 内視鏡所見から見た生物学的製剤によるクローン病術後吻合部再燃防止効果

    田鍾寛, 木村英明, 稲垣尚子, 佐々木智彦, 高蓮浩, 国崎玲子, 遠藤格

    日本外科学会雑誌   115   2014

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  • 局所切除で長期観察した特発性巨大結腸症の1例

    矢澤慶一, 木村英明, 高蓮浩, 国崎玲子, 遠藤格

    日本大腸こう門病学会雑誌   67 ( 9 )   2014

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  • IBDの医療面接(メディカルインタビュー)を極める!ナラティブの重要性:患者の悩みを的確に探る

    国崎玲子, 小椋千沙, 木村英明, 前田愼

    IBD Research   8 ( 2 )   2014

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  • 難治性炎症性腸管障害に関する調査研究 診療ガイドライン作成・改訂 炎症性腸疾患診療ガイドラインの作成と改訂

    上野文昭, 渡邉聡明, 松井敏幸, 渡辺守, 井上詠, 小俣富美雄, 加藤順, 国崎玲子, 小金井一隆, 小林清典, 小林健二, 猿田雅之, 仲瀬裕志, 長堀正和, 平井郁仁, 本谷聡, 野口善令

    難治性炎症性腸管障害に関する調査研究 平成25年度 総括・分担研究報告書   2014

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  • 小児期発症クローン病と診断されていたX連鎖リンパ増殖症候群2型(XLP-type2)の1例

    国崎玲子, 稲垣尚子, 佐々木智彦, 高蓮浩, 田鐘寛, 小笠原康夫, 木村英明, 原拓麿, 森雅亮, 金兼弘和, 前田愼

    日本小児IBD研究会プログラム・抄録集   14th   2014

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  • 大腸疾患アトラス II.非限局性病変・多発病変 2 平坦ないし陥凹性病変 B.粘膜変化・色調変化が主体 潰瘍性大腸炎

    小柏剛, 国崎玲子, 木村英明

    消化器内視鏡   26 ( 12 )   2014

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  • Q&A-専門医に聞くIBD-IBD患者さんは子どもができにくいのでしょうか?

    国崎玲子, 木村英明

    IBD Research   8 ( 4 )   2014

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  • 難治クローン病と診断されていたX連鎖リンパ増殖症候群2型(XLP-type2)症例の検討

    小柏剛, 国崎玲子, 津田早耶, 安原ひさ恵, 高蓮浩, 木村英明, 原拓磨, 森雅亮, 金兼弘和, 前田愼

    日本消化器病学会大会(Web)   56th   2014

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  • Hand assisted laparoscopic surgery(HALS)とVideo assisted intrapelvic surgery(VIPS)による一期的大腸全摘,回腸嚢肛門管吻合術

    木村英明, 矢澤慶一, 高蓮浩, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 井上英美, 遠藤格

    日本大腸こう門病学会雑誌   67 ( 9 )   2014

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  • ベーチェット病の上部消化管病変の検討

    安原ひさ恵, 国崎玲子, 津田早耶, 小柏剛, 高蓮浩, 木村英明, 前田愼

    日本消化器病学会大会(Web)   56th   2014

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  • ベーチェット病腸管病変に対する5-ASA製剤による寛解導入効果の検討

    津田早耶, 国崎玲子, 小柏剛, 安原ひさ恵, 高連浩, 木下裕人, 木村英明, 前田愼

    日本消化器病学会大会(Web)   56th   2014

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  • 炎症性腸疾患症例におけるCVC関連感染症(CRBSI)の疫学,起因菌および危険因子の解析~単施設305例の後方視コホート研究から~

    稲垣尚子, 柴田渉, 木村英明, 国崎玲子, 佐々木智彦, 高蓮浩, 大庭真梨, 大毛宏喜, 前田愼

    静脈経腸栄養   29 ( 1 )   2014

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  • クローン病腸管病変の外科治療における新たな治療戦略

    木村英明, 原田真吾, 井上英美, 井上英美, 池田良輔, 佐々木智彦, 木下裕人, 国崎玲子, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   46 ( Supplement1 )   2013

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  • 潰瘍性大腸炎における深部静脈血栓症の術前診断の検討

    原田真吾, 木村英明, 池田良輔, 佐々木智彦, 木下裕人, 国崎玲子, 遠藤格

    日本消化器外科学会雑誌(Web)   46 ( Supplement1 )   2013

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  • IBD症例における血流感染症の検討

    芝田渉, 芝田渉, 国崎玲子, 曾原雅子, 曾原雅子, 呉蓉榕, 呉蓉榕, 岩佐美穂, 岩佐美穂, 中畑仁美, 中畑仁美, 山口唯史, 山口唯史, 松本大海, 松本大海, 岡田真央, 岡田真央, 谷口賢新郎, 谷口賢新郎, 林亜葵, 林亜葵, 稲沢真, 稲沢真, 稲垣尚子, 佐々木智彦, 高蓮浩, 高蓮浩, 木村英明, 大河原愛, 宮島栄治, 大毛宏喜, 前田愼

    日本消化器病学会雑誌   110   2013

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  • 潰瘍性大腸炎に対する外科治療の現状と展望

    木村英明, 井上英美, 佐々木智彦, 国崎玲子, 辰巳健志, 小金井一隆, 杉田昭, 遠藤格

    日本大腸こう門病学会雑誌   66 ( 9 )   2013

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  • 炎症性腸疾患の診断と治療;最近の進歩 重症潰瘍性大腸炎の内科的治療とその限界

    木下裕人, 国崎玲子, 池田良輔, 佐々木智彦, 原田真吾, 木村英明, 遠藤格, 前田愼

    消化器外科   36 ( 1 )   2013

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  • 術後合併症からみた重症潰瘍性大腸炎における内科的治療の限界

    木村英明, 国崎玲子, 遠藤格

    消化と吸収   36 ( 1 )   2013

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  • 潰瘍性大腸炎術後回腸嚢炎の現状と問題点

    木村英明, 井上英美, 松林真央, 佐々木智彦, 木下裕人, 国崎玲子, 小金井一隆, 杉田昭, 遠藤格

    日本外科学会雑誌   114   2013

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  • 腸管嚢胞状気腫症に対するメトロニダゾール経口投与による治療経験

    国崎玲子, 呉蓉榕, 池田良輔, 佐々木智彦, 木下裕人, 村田依子, 藤澤信隆, 芝田渉, 木村英明, 前田愼

    日本内科学会雑誌   102   2013

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  • 大腸全摘術を受けた小児潰瘍性大腸炎2例の心理的変遷の検討

    小椋(進藤)千沙, 小椋(進藤)千沙, 小椋(進藤)千沙, 国崎玲子, 山本壽恵, 木下裕人, 松田玲圭, 中戸川満智子, 開田脩平, 木村英明, 前田愼

    日本小児栄養消化器肝臓学会雑誌   27 ( 2 )   2013

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  • Management of Pregnancy in Inflammatory Bowel Disease

    国崎玲子, 木下裕人, 佐々木智彦, 山本壽恵, 松田玲圭, 木村英明, 奥田美加, 高橋恒男, 前田愼

    胃と腸   48 ( 5 )   2013

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  • 活動期潰瘍性大腸炎に対する成分栄養剤投与の検討

    山本壽恵, 須賀泰世, 木下裕人, 松田玲圭, 中戸川満智子, 鈴木紳祐, 木村英明, 国崎玲子, 前田愼

    静脈経腸栄養   27 ( 1 )   2012

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  • 術後合併症からみた重症潰瘍性大腸炎に対する治療戦略

    木村英明, 井上英美, 国崎玲子, 小金井一隆, 杉田昭, 遠藤格

    日本大腸こう門病学会雑誌   65 ( 9 )   2012

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  • クローン病患者の食事の作り手の意識と問題点の検討~アンケート調査から~

    村田依子, 村田依子, 山本壽恵, 小椋千沙, 木下裕人, 佐々木智彦, 松林真央, 松田玲圭, 中戸川満智子, 藤澤信隆, 芝田渉, 木村英明, 清水香織, 松岡朋子, 守屋隆, 国崎玲子, 前田愼

    日本消化器病学会雑誌   109   2012

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  • クローン病のTherapeutic Strategy-mucosal healingは治療のゴールか IV クローン病治療戦略-どのような患者に用いるか(5)新たな栄養療法

    国崎玲子, 木下裕人, 佐々木智彦, 松林真央, 村田依子, 藤澤信隆, 芝田渉, 木村英明, 前田慎

    Intestine   16 ( 3 )   2012

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  • 当院におけるIBD患者の妊娠・出産に関する意識調査

    村田依子, 村田依子, 国崎玲子, 山本壽恵, 木下裕人, 佐々木智彦, 松田玲圭, 中戸川満智子, 松林真央, 藤澤信隆, 芝田渉, 木村英明, 幡野一帆, 里村明菜, 田中千春, 長野麻由子, 大沼教子, 前田愼

    日本消化器病学会雑誌   109   2012

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  • クローン病小腸病変の活動性診断における体外式超音波ドプラ法の有用性

    佐々木智彦, 佐々木智彦, 国崎玲子, 木村英明, 半澤秋帆, 柴田尚美, 米澤広美, 宮島栄治, 藤井正一, 沼田和司, 田中克明, 野澤昭典, 田中正則, 前田愼

    日本消化器病学会雑誌   109   2012

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  • 小児潰瘍性大腸炎に対する外科治療

    鈴木紳祐, 木村英明, 国崎玲子, 小金井一隆, 杉田昭, 遠藤格

    日本外科学会雑誌   113   2012

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  • 重症潰瘍性大腸炎に対する外科治療

    木村英明, 鈴木紳祐, 国崎玲子, 小金井一隆, 杉田昭, 遠藤格

    日本外科学会雑誌   113   2012

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  • クローン病の栄養療法に対する患者の意識と問題点の検討

    松林真央, 山本壽恵, 小椋千沙, 木下裕人, 佐々木智彦, 松田玲圭, 中戸川満智子, 村田依子, 藤澤信隆, 芝田渉, 勅使川原晴佳, 中園美紗子, 野田龍一, 游昌子, 木村英明, 国崎玲子, 前田愼

    日本消化器病学会雑誌   109   2012

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  • クローン病の発病前後における食事変遷と食事療法における問題点~アンケート調査から~

    松林真央, 山本壽恵, 小椋千沙, 木下裕人, 佐々木智彦, 松田玲圭, 中戸川満智子, 村田依子, 藤澤信隆, 芝田渉, 木村英明, 清水香織, 松岡朋子, 守屋隆, 国崎玲子, 前田愼

    日本消化器病学会雑誌   109   2012

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  • 潰瘍性大腸炎周術期における患者の心的変遷とQOLの検討

    小椋千沙, 小椋千沙, 小椋千沙, 国崎玲子, 井上英美, 松林真央, 佐々木智彦, 木下裕人, 木村英明, 前田愼, 遠藤格

    日本大腸こう門病学会雑誌   65 ( 9 )   2012

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  • クローン病小腸病変の活動性診断における体外式超音波ドプラ法の有用性に関する基礎的検討

    佐々木智彦, 佐々木智彦, 国崎玲子, 木村英明, 藤井正一, 沼田和司, 田中克明, 神美郷, 半澤秋帆, 柴田尚美, 米澤広美, 宮島栄治, 小寺輝明, 野澤昭典, 田中正則, 前田愼

    日本大腸検査学会総会プログラム・抄録集   30th   2012

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  • 潰瘍性大腸炎のTherapeutic Strategy-Standardな治療法から最新情報まで(12)妊娠・授乳期における内科的治療

    国崎玲子, 山本壽恵, 木下裕人, 松田玲圭, 中戸川満知子, 鈴木紳祐, 木村英明, 前田慎, 山口瑞穂, 奥田美加, 高橋恒男

    Intestine   15 ( 3 )   2011

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  • クローン病小腸病変に対する外科治療

    木村英明, 藪下泰宏, 上奈津子, 国崎玲子, 山本壽恵, 小金井一隆, 杉田昭, 遠藤格

    日本外科学会雑誌   112   2011

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  • Infliximab療法中に妊娠・分娩に至ったクローン病合併妊娠の2例

    山本壽恵, 国崎玲子, 上奈津子, 中戸川満智子, 松田玲圭, 高橋直行, 木村英明, 前田愼

    日本消化器病学会雑誌   108   2011

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  • 消化管感染症の現況-最近の知見,診断のポイント VII 細菌・真菌・クラミジアによる消化管障害(4)カンピロバクター

    松田玲圭, 国崎玲子, 山本壽恵, 上奈津子, 高橋直行, 木村英明, 前田慎

    臨床消化器内科   26 ( 7 )   2011

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  • 体外式超音波検査における手術危険因子の検討

    佐々木智彦, 国崎玲子, 山本壽恵, 上奈津子, 松田玲圭, 木村英明, 沼田和司, 田中克明, 前田愼

    日本消化器病学会雑誌   108   2011

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  • クローン病の骨代謝障害

    国崎玲子, 山本壽恵, 上奈津子, 中戸川満智子, 松田玲圭, 藪下泰宏, 木村英明

    臨床消化器内科   26 ( 4 )   2011

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  • 活動期潰瘍性大腸炎に対する成分栄養剤投与の検討

    山本壽恵, 須賀泰世, 木下裕人, 松田玲圭, 中戸川満智子, 鈴木紳祐, 木村英明, 国崎玲子, 前田愼

    日本消化器病学会雑誌   108   2011

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  • 生物学的製剤導入後におけるクローン病の外科治療成績

    木村英明, 高橋直行, 上奈津子, 山本壽恵, 国崎玲子, 小金井一隆, 杉田昭, 遠藤格

    日本消化器外科学会雑誌(Web)   44 ( Supplement1 )   2011

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  • 当院におけるクローン病合併妊娠の臨床的検討

    山本壽恵, 中戸川満智子, 木村英明, 長沼誠, 山口瑞穂, 奥田美加, 高橋恒男, 前田愼, 国崎玲子

    日本消化器病学会雑誌   108   2011

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  • タクロリムスによる潰瘍性大腸炎治療における内視鏡検査の有用性

    木下裕人, 国崎玲子, 山本壽恵, 松田玲圭, 中戸川満知子, 鈴木紳祐, 木村英明, 前田愼

    日本大腸検査学会総会プログラム・抄録集   29th   2011

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  • 潰瘍性大腸炎-長期経過観察例の諸問題 7 妊娠・出産は再燃・増悪因子となる?

    国崎玲子, 山本壽恵, 木村英明, 前田慎, 山口瑞穂, 奥田美加, 高橋恒男

    臨床消化器内科   26 ( 8 )   2011

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  • 骨粗鬆症 続発性骨粗鬆症の実地診療 炎症性腸疾患

    国崎玲子, 木村英明

    Medical Practice   27 ( 6 )   2010

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  • 意識障害で救急来院した,家族性大腸腺腫症で予防的大腸全摘術および回腸人工肛門増設術施行後のマグネシウム欠乏症の治療経験

    上奈津子, 国崎玲子, 森岡友, 山本壽恵, 藪下泰宏, 木村英明

    日本大腸こう門病学会雑誌   63 ( 9 )   2010

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  • 当院におけるTacrolimusによるInfliximab抵抗性クローン病に対する治療経験

    山本壽恵, 木村英明, 国崎玲子

    日本消化器病学会雑誌   107   2010

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  • 外科治療とサイクロスポリン療法の治療成績からみた重症潰瘍性大腸炎の治療方針

    木村英明, 国崎玲子, 藪下泰宏, 山本壽恵, 上奈津子, 小金井一隆, 杉田昭, 遠藤格

    日本大腸こう門病学会雑誌   63 ( 9 )   2010

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  • 腸管嚢胞状気腫症に対するメトロニダゾール経口投与による治療経験

    山本壽恵, 国崎玲子, 上奈津子, 中戸川満智子, 松田玲圭, 藪下泰宏, 木村英明

    日本大腸こう門病学会雑誌   63 ( 9 )   2010

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  • 腸管と骨・ミネラル代謝 2 臨床(2)炎症性腸疾患と骨代謝

    国崎玲子, 木村英明

    季刊腎と骨代謝   23 ( 2 )   2010

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  • 小腸・大腸内視鏡 こんな時どうする-診断編 II 大腸炎症性病変の診断(1)診断困難な大腸急性炎症性疾患に対する対応 b.内視鏡検査の適応と鑑別を中心に

    国崎玲子, 山本壽恵, 上奈津子, 中戸川満智子, 松田玲圭, 藪下泰宏, 木村英明

    Intestine   14 ( 4 )   2010

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  • 体外式超音波検査によるクローン病小腸病変の治療戦略

    木村英明, 国崎玲子, 小金井一隆, 杉田昭, 福島恒男

    日本臨床外科学会雑誌   70   2009

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  • 消化器炎症性疾患の病因解明と治療-どこまで進んでいるか-4.クローン病の病因と治療

    木村英明, 杉田昭, 小金井一隆, 国崎玲子, 福島恒男

    Surgery Frontier   16 ( 2 )   2009

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  • 11年の長期経過を内視鏡で観察しえたCrohn病・胃十二指腸狭窄の一例

    大西奈緒美, 国崎玲子, 木村英明, 杉田昭, 小林清典, 勝又伴栄

    Gastroenterological Endoscopy   50 ( Supplement 2 )   2008

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  • 小児Crohn病の骨代謝障害に各種治療薬が与える影響の検討

    国崎玲子, 森岡友, 大西奈緒美, 佐藤知子, 藤井彩子, 樅山将士, 小野秀高, 成井一隆, 木村英明, 田中克明

    日本小児栄養消化器肝臓学会雑誌   22 ( 1 )   2008

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  • 小腸内視鏡検査で多発潰瘍を観察した結節性多発動脈炎の一例

    二本松宏美, 国崎玲子, 小野秀高, 木村英明, 田中克明, 田中克明, 矢原青, 平澤欣吾, 岡裕之, 徳永麻裕美, 佐々木毅

    Gastroenterological Endoscopy   50 ( Supplement 2 )   2008

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  • Infectious Enteritides to be Differentiated from Inflammatory Bowel Disease (IBD)

    国崎玲子, 木村英明, 野沢昭典, 杉田昭, 田中克明

    胃と腸   43 ( 11 )   2008

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  • 腸管Behcet病に対するInfliximab療法-当科の治療成績と既報告における検討-

    国崎玲子, 木村英明, 田中克明

    日本消化器病学会雑誌   105   2008

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  • カプセル内視鏡で小腸病変を観察した結節性多発動脈炎の一例

    森岡友, 国崎玲子, 成井一隆, 木村英明, 田中克明, 岡裕之, 金田朋子, 平和伸仁, 佐々木毅

    Gastroenterological Endoscopy   50 ( Supplement 2 )   2008

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  • 体外式超音波検査による小腸炎症性疾患の診断と治療効果判定

    国崎玲子, 木村英明, 沼田和司

    日本消化器病学会雑誌   104   2007

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  • hypereosinophilia-associated disease3例の長期経過と治療についての考察

    青木 昭子, 国崎 玲子, 岳野 光洋, 石ヶ坪 良明

    日本臨床免疫学会会誌   29 ( 4 )   268 - 268   2006.8

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    Language：Japanese   Publisher：日本臨床免疫学会  

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  • Infliximab and the bone in Crohn's disease [1]

    R. Kunisaki, O. Chaki, T. Taguchi, T. Sugiyama, A. Sugita

    Alimentary Pharmacology and Therapeutics   21 ( 6 )   789 - 790   2005.3

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    Language：English   Publishing type：Rapid communication, short report, research note, etc. (scientific journal)  

    DOI： 10.1111/j.1365-2036.2005.02400.x

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Awards

  • 指導者賞

    2018.4   日本内科学会  

    国崎 玲子

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  • Best teacher

    2017.6  

    KUNISAKI Reiko

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Research Projects

  • Generation of evidence through registry construction by genome-wide subtype analysis of Behcet's disease

    Grant number：19H03700  2019.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant amount：\17290000 （ Direct Cost: \13300000 、 Indirect Cost：\3990000 ）

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