Updated on 2026/04/28

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写真a

 
Nobuhito Hirawa
 
Organization
YCU Medical Center Devision of Nephrology and Hypertension Associate Professor
Title
Associate Professor
Profile
内科学、腎臓内科学、高血圧学、血液浄化療法などの臨床と教育、研究を続けています。高血圧の成因遺伝子、CKDの病態と治療、血液透析や白血球除去療法、血漿交換療法の適応と効果など幅広く研究するとともに、医学生から初期臨床研修、専門医研修などシームレスの教育を目指しています。また、患者さんに最高の治療を提供できるようにチーム医療の実践にチャレンジしています。
External link

Degree

  • (BLANK) ( Yokohama City University )

Research Interests

  • 血液浄化

  • 腎臓病学

  • Hypertension

  • 内科学

Research Areas

  • Life Science / General internal medicine

  • Life Science / Nephrology

  • Life Science / Cardiology

Education

  • Yokohama City University   Graduate School of Medicine   Second Department of Internal Medicine

    1987.4 - 1991.3

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  • Yokohama City University   Faculty of Medicine   School of Medicine

    1981.4 - 1987.3

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Research History

  • Yokohama City University Medical Center   Advisor to the President

    2020.9

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  • Yokohama City University Medical Center   Department of Nephrology and Hypertension   Director

    2018.4

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  • Yokohama City University   Medical Center

    2012

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  • Yokohama City University Medical Center   Director of the Department of Hemodialysis and Apheresis

    2008

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  • Division of Nephrology and Hypertension   Associate Professor

    2005

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  • Yokohama City University   Medical Center

    2004 - 2005

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  • Yokohama City University   Graduate

    2001 - 2004

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  • 横浜市立大学 医学部 助手

    1999 - 2004

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  • The University of Tokyo   Faculty of Medicine

    1998 - 1999

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  • 関東逓信病院 腎臓内科 研究員

    1993 - 1998

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  • 関東逓信病院 腎臓内科 常勤医

    1991 - 1993

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Professional Memberships

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Committee Memberships

  • Japanese Society for Dialysis Therapy   Trustee  

    2022.6   

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    Committee type:Academic society

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  • American Collage of Physicians, Japan Chapter   Trustee (理事)  

    2019.7   

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    Committee type:Academic society

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  • 神奈川透析医会   理事  

    2017   

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    Committee type:Academic society

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  • 日本高血圧学会   高血圧治療ガイドライン2019統括委員会付幹事  

    2016.12   

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    Committee type:Academic society

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  • 日本高血圧学会   専門医制度委員会 委員  

    2016.12   

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    Committee type:Academic society

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  • 日本高血圧学会   試験小委員会 副委員長  

    2016.12   

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    Committee type:Academic society

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  • 日本高血圧学会   高血圧治療ガイドライン2019作成委員会 事務局長  

    2016.12   

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    Committee type:Academic society

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  • American College of Physicians, Japan Chapter   Local Nomination Committee, Chairperson  

    2014.7 - 2018.6   

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    Committee type:Academic society

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  • 日本腎臓学会   倫理委員会 委員  

    2014.4   

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    Committee type:Academic society

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  • 日本腎臓学会   総務委員会 委員  

    2014.4   

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    Committee type:Academic society

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  • 日本透析医学会   国際学術交流委員会 副委員長  

    2012.7   

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    Committee type:Academic society

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  • 日本内分泌学会   評議員  

    2012   

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    Committee type:Academic society

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  • 日本透析医学会   専門医制度委員会 カリキュラム小委員会  

    2012   

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  • 日本腎臓学会   将来構想検討ワーキングチーム  

    2012 - 2014.3   

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    Committee type:Academic society

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  • 日本腎臓学会   編集委員会査読委員  

    2011   

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  • 日本高血圧学会   試験小委員会  

    2010 - 2016.12   

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  • 日本内分泌学会   代議員  

    2010 - 2012   

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    Committee type:Academic society

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  • 日本高血圧学会   指導医  

    2008   

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    Committee type:Academic society

    日本高血圧学会

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  • 日本腎臓学会   法人評議員  

    2008   

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    Committee type:Academic society

    日本腎臓学会

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  • 日本透析医学会   編集委員会委員  

    2008   

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    Committee type:Academic society

    日本透析医学会

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  • 日本透析医学会   国際学術交流委員会委員  

    2008   

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    Committee type:Academic society

    日本透析医学会
    副委員長(2012-)

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  • American College of Physicians   Japan Chapter, Nomination-Committee  

    2008 - 2018   

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    Committee type:Academic society

    American College of Physicians
    Vice-chairperson

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  • 日本透析医学会   国際協力推進小委員会委員  

    2008   

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    Committee type:Academic society

    日本透析医学会

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  • Japanese Society for Dialysis Therapy   Committee of International Communication for Academic Research  

    2008   

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    Committee type:Academic society

    Japanese Society for Dialysis Therapy

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  • Japanese Society of Nephrology   Councilor  

    2008   

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    Committee type:Academic society

    Japanese Society of Nephrology

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  • Japanese Society for Dialysis Therapy   Committee of International Cooperation  

    2008   

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    Committee type:Academic society

    Japanese Society for Dialysis Therapy

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  • Japanese Society for Dialysis Therapy   Editorial Board  

    2008   

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    Committee type:Academic society

    Japanese Society for Dialysis Therapy

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  • Japanese Society of Hypertension   Adovisory Doctor  

    2008   

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    Committee type:Academic society

    Japanese Society of Hypertension

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  • American College of Physicians   Japan Chapter, Nomination-Committee  

    2008   

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    Committee type:Academic society

    American College of Physicians

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  • 日本アフェレシス学会   評議員  

    2007   

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    Committee type:Academic society

    日本アフェレシス学会

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  • 日本腎臓学会   学術委員会CKD診療ガイドライン作成ワーキング委員  

    2007 - 2009   

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    Committee type:Academic society

    日本腎臓学会

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  • Japanese Society for Apheresis   Councilor  

    2007   

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    Committee type:Academic society

    Japanese Society for Apheresis

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  • American College of Physicians   Fellow (FACP)  

    2006   

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    Committee type:Academic society

    American College of Physicians

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  • American College of Physicians   Fellow (FACP)  

    2006   

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    Committee type:Academic society

    American College of Physicians

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  • 日本アフェレシス学会   指導医  

    2005   

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    Committee type:Academic society

    日本アフェレシス学会

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  • Japanese Society for Apheresis   Adovisory Doctor  

    2005   

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    Committee type:Academic society

    Japanese Society for Apheresis

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  • 日本内分泌学会   指導医  

    2004.4   

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    Committee type:Academic society

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  • 日本透析医学会   評議員  

    2004   

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    Committee type:Academic society

    日本透析医学会

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  • American College of Physicians   Japan Chapter, Publication-Committee  

    2004 - 2008   

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    Committee type:Academic society

    American College of Physicians

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  • Japanese Society for Dialysis Therapy   Councilor  

    2004   

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    Committee type:Academic society

    Japanese Society for Dialysis Therapy

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  • Japanese Society of Endocrinology   Supervisory Doctor  

    2004   

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    Committee type:Academic society

    Japanese Society of Endocrinology

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  • American College of Physicians   Japan Chapter, Publication-Committee  

    2004   

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    Committee type:Academic society

    American College of Physicians

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  • American Heart Association High Blood Pressure Council   Fellow (FAHA)  

    2003   

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    Committee type:Academic society

    American Heart Association High Blood Pressure Council

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  • 日本腎臓学会   卒前・卒後教育委員会委員  

    2002   

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    Committee type:Academic society

    日本腎臓学会

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  • 日本腎臓学会   学術評議員  

    2002   

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    Committee type:Academic society

    日本腎臓学会

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  • 日本高血圧学会   評議員  

    2002   

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    Committee type:Academic society

    日本高血圧学会

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  • Japanese Society of Hypertension   Councilor  

    2002   

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    Committee type:Academic society

    Japanese Society of Hypertension

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  • Japanese Society of Nephrology   Councilor (Academic)  

    2002   

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    Committee type:Academic society

    Japanese Society of Nephrology

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  • Japanese Society of Nephrology   Committee of Education  

    2002   

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    Committee type:Academic society

    Japanese Society of Nephrology

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  • 日本内科学会   指導医  

    1999   

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    Committee type:Academic society

    日本内科学会

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  • Japanese Society of Internal Medicine   Supervisory Doctor  

    1999   

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    Committee type:Academic society

    Japanese Society of Internal Medicine

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  • 日本透析医学会   指導医  

    1997   

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    Committee type:Academic society

    日本透析医学会

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  • Japanese Society for Dialysis Therapy   Adovisory Doctor  

    1997   

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    Committee type:Academic society

    Japanese Society for Dialysis Therapy

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Papers

  • Key highlights of the Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025). International journal

    Yusuke Ohya, Atsushi Sakima, Hisatomi Arima, Ako Fukami, Masato Furuhashi, Mari Ishida, Toshihiko Ishimitsu, Hisashi Kai, Kiyoshi Matsumura, Katsuyuki Miura, Masashi Mukoyama, Masanori Munakata, Takatoshi Ohkubo, Hiromi Rakugi, Takeshi Takami, Takuya Tsuchihashi, Nobuhito Hirawa

    Hypertension research : official journal of the Japanese Society of Hypertension   48 ( 10 )   2500 - 2511   2025.10

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    Japan has long maintained a robust national health system with universal health coverage and accessible antihypertensive therapy. Nevertheless, population-level blood pressure (BP) control remains suboptimal. To address this public health challenge, the Japanese Society of Hypertension published the Guidelines for the Management of Elevated Blood Pressure and Hypertension 2025 (JSH2025), integrating evidence-based recommendations and practical approaches to improve hypertension care. JSH2025 introduces a dual-format structure comprising clinical question sections developed through systematic reviews and consensus-based narrative chapters. The key updates include universal BP targets of <130/80 mmHg across populations, promotion of home BP monitoring, stratified cardiovascular risk assessment, expanded guidance on digital health and behavioral interventions, and condition-specific management strategies for older adults, women, and cancer survivors. We outline the major updates and innovations in JSH2025 and show their clinical and public health implications.

    DOI: 10.1038/s41440-025-02331-8

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  • Visualizing fatigue mechanisms in non-communicable diseases: an integrative approach with multi-omics and machine learning. International journal

    Yusuke Kobayashi, Naoki Fujiwara, Yuki Murakami, Shoichi Ishida, Sho Kinguchi, Tatsuya Haze, Kengo Azushima, Akira Fujiwara, Hiromichi Wakui, Masayoshi Sakakura, Kei Terayama, Nobuhito Hirawa, Tetsuo Isozaki, Hiroaki Yasuzaki, Hajime Takase, Yuichiro Yano, Kouichi Tamura

    BMC medical informatics and decision making   25 ( 1 )   204 - 204   2025.6

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    BACKGROUND: Fatigue is a prevalent and debilitating symptom of non-communicable diseases (NCDs); however, its biological basis are not well-defined. This exploratory study aimed to identify key biological drivers of fatigue by integrating metabolomic, microbiome, and genetic data from blood and saliva samples using a multi-omics approach. METHODS: Metabolomic, microbiome, and single nucleotide polymorphisim analyses were conducted on saliva and blood samples from 52 patients with NCDs. Fatigue dimensions were assessed using the Multidimensional Fatigue Inventory and correlated with biological markers. LightGBM, a gradient boosting algorithm, was used for fatigue prediction, and model performance was evaluated using the F1-score, accuracy, and receiver operating characteristic area under the curve using leave-one-out cross-validation. Statistical analyses included correlation tests and multiple comparison adjustments (p < 0.05; false discovery rate <0.05). This study was approved by the Yokohama City University Hospital Ethics Committee (F230100022). RESULTS: Plasmalogen synthesis was significantly associated with physical fatigue in both blood and saliva samples. Additionally, homocysteine degradation and catecholamine biosynthesis in the blood were significantly associated with mental fatigue (Holm p < 0.05). Microbial imbalances, including reduced levels of Firmicutes negativicutes and Patescibacteria saccharimonadia, correlated with general and physical fatigue (r = - 0.379, p = 0.006). Genetic variants in genes, such as GPR180, NOTCH3, SVIL, HSD17B11, and PLXNA1, were linked to various fatigue dimensions (r range: -0.539-0.517, p < 0.05). Machine learning models based on blood and salivary biomarkers achieved an F1-score of approximately 0.7 in predicting fatigue dimensions. CONCLUSION: This study provides preliminary insights into the potential involvement of alterations in lipid metabolism, catecholamine biosynthesis disruptions, microbial imbalances, and specific genetic variants in fatigue in patients with NCDs. These findings lay the groundwork for personalized interventions, although further validation and model refinement across diverse populations are needed to enhance the prediction performance and clinical applicability.

    DOI: 10.1186/s12911-025-03034-3

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  • Switching from ARBs to sacubitril/valsartan safely improves 24-hour ambulatory blood pressure in patients with advanced chronic kidney disease. International journal

    Sho Kinguchi, Kohei Ishiga, Hiromichi Wakui, Kengo Azushima, Tomohiko Kanaoka, Yusuke Kobayashi, Tatsuya Haze, Nobuhito Hirawa, Kouichi Tamura

    American journal of hypertension   2025.3

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    BACKGROUND: We investigated the effects of sacubitril/valsartan, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI), on 24-hour blood pressure (BP) and safety for 12 weeks in Japanese patients with non-dialysis advanced chronic kidney disease (CKD). METHODS: We conducted a prospective, single-arm exploratory study. Patients with non-dialysis CKD stage G4-5 (estimated glomerular filtration (eGFR) <30 mL/min/1.73 m2) who did not achieve their BP goals with angiotensin receptor blocker (ARB) administration, were enrolled and switched to sacubitril/valsartan. Primary and key secondary endpoints were changes from baseline in the 24-hour systolic BP (SBP) measured via ambulatory BP monitoring (ABPM) over 12 weeks and the safety, especially incidence of serum creatinine (Cr) increase (≥30% increase from baseline) and hyperkalemia. RESULTS: Thirty patients were enrolled, and 29 patients were switched to sacubitril/valsartan. Efficacy analysis was conducted on 26 patients. Baseline mean eGFR and office BP were 21.1±5.0 mL/min/1.73m2 and 149.4±23.7/80.7±11.9 mmHg, respectively. Baseline 24-hour, daytime, and nighttime BP were 139.6±17.7/77.0±7.8 mmHg, 143.5±18.5/79.6±8.7 mmHg, and 131.0±20.4/71.1±8.8 mmHg, respectively. After 12 weeks, changes in 24-hour, daytime, and nighttime SBP from baseline were -7.1±12.4 mmHg (P <0.01), -7.7±12.9 mmHg (P <0.01), and -5.8±15.8 mmHg (P = 0.07), respectively. No incidences of potassium values >6.0 mmol/L or serum Cr ≥30% increase from baseline were reported after sacubitril/valsartan initiation. CONCLUSIONS: Switching from ARB to sacubitril/valsartan can safely enhance 24-hour antihypertensive treatment in patients with non-dialysis CKD G4-5 who do not achieve BP goals with ARBs.CLINICAL TRIALS REGISTRATION: Trial Number jRCT1031220149.

    DOI: 10.1093/ajh/hpaf028

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  • サクビトリルバルサルタンの慢性腎臓病G4-5患者における診察室外血圧への有効性と安全性

    石賀 浩平, 金口 翔, 小豆島 健護, 金岡 知彦, 涌井 広道, 平和 伸仁, 田村 功一

    日本高血圧学会総会プログラム・抄録集   46回   372 - 372   2024.10

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    Language:Japanese   Publisher:(NPO)日本高血圧学会  

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  • Behcet's disease presenting as malignant hypertension induced by renovascular hypertension.

    Sho Kinguchi, Misumi Tamura, Rika Furuta, Kazuki Toyota, Kohei Ishiga, Tomohiko Kanaoka, Kengo Azushima, Hiromichi Wakui, Nobuhito Hirawa, Kouichi Tamura

    CEN case reports   2024.7

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    Hypertension is an uncommon manifestation of Behcet's disease, which is also an uncommon cause of renovascular hypertension. We herein report a case of malignant hypertension associated with unilateral renal artery stenosis due to vascular Behcet's disease. A 19-year-old man, who had no significant medical history, was referred to ophthalmology at our hospital because he was suspected to have uveitis and Vogt-Koyanagi-Harada syndrome. In addition to poor eyesight, he had been aware of a fever, loss of appetite, and weight loss for a month. He was admitted with markedly elevated blood pressure (222/140 mmHg), hypertensive retinopathy, and acute kidney injury, who was diagnosed with malignant hypertension. Laboratory findings showed high plasma renin activity and plasma aldosterone concentration, hypokalemia, and elevated inflammatory response. Computed tomography showed an atrophic right kidney and a compensatorily enlarged left kidney. Renal computed tomography angiography revealed severe and diffuse stenosis of the right renal artery, and stenosis of the ostium of celiac artery. Since he was suspected to have uveitis and his inflammatory responses were elevated on admission, we listed Behcet's disease as a differential diagnosis. Medical interview and examination focusing on Behcet's disease revealed that the patient had recurrent oral aphthous lesions and folliculitis, and a positive pathergy test, which led to the patient being diagnosed with vascular Behcet's disease. After admission, his blood pressure was well controlled with multiple antihypertensive drugs including an angiotensin receptor/neprilysin inhibitor, and his oral aphthous lesions and skin lesion were improved with colchicine. When young men who are at a higher risk for vascular Behcet's disease show renovascular hypertension with an elevated inflammatory reaction, vascular Behcet's disease should be considered as a differential diagnosis.

    DOI: 10.1007/s13730-024-00918-7

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  • Favorable changes in the eGFR slope after dapagliflozin treatment and its association with the initial dip.

    Rina Kawano, Tatsuya Haze, Akira Fujiwara, Aiko Haruna, Moe Ozawa, Yusuke Kobayashi, Sanae Saka, Nobuhito Hirawa, Kouichi Tamura

    Clinical and experimental nephrology   2024.7

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    BACKGROUND: Renoprotective effects of sodium glucose transporter 2 (SGLT2) inhibitors, including dapagliflozin, were observed in randomized controlled trials (RCTs). The suspected underlying mechanism is a correction of hyperfiltration, observed as an "initial dip". Whether SGLT2 inhibitors can attenuate the rate of decline in the estimated glomerular filtration rate (eGFR) in clinical settings, even when considering the pre-treatment decline rate, is unknown. Although several RCTs identified an association between the initial dip and long-term renal prognoses, a conclusion has not been reached. METHODS: We collected the eGFR data of patients for whom dapagliflozin was initiated in our hospital and then calculated their eGFR slopes before and after the start of the treatment. We investigated the changes in the eGFR slopes (ΔeGFR slope) and the association between the ΔeGFR slope and the initial dip. Risks for rapid eGFR decliners (eGFR slope < - 3 mL/min/1.73 m2/year) were also examined. RESULTS: The eGFR slope was significantly milder after dapagliflozin treatment (p < 0.01). A deeper initial dip was associated with a milder rate of eGFR decline (adjusted beta: - 0.29, p < 0.001). Dapagliflozin treatment reduced the proportion of rapid eGFR decliners from 52.9 to 14.7%, and a smaller initial dip was identified as a significant risk for post-treatment rapid eGFR decline (adjusted odds ratio: 1.73, p < 0.05). CONCLUSIONS: Compared to before the administration of dapagliflozin, the rate of eGFR decline was significantly milder after its administration. The initial dip was significantly associated with long-term renoprotective effects and may be a useful predictor of treatment response.

    DOI: 10.1007/s10157-024-02532-4

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  • Author Correction: Effectiveness of DialBetesPlus, a self-management support system for diabetic kidney disease: Randomized controlled trial. International journal

    Kayo Waki, Mitsuhiko Nara, Syunpei Enomoto, Makiko Mieno, Eiichiro Kanda, Akiko Sankoda, Yuki Kawai, Kana Miyake, Hiromichi Wakui, Yuya Tsurutani, Nobuhito Hirawa, Tadashi Yamakawa, Shiro Komiya, Akihiro Isogawa, Shinobu Satoh, Taichi Minami, Tamio Iwamoto, Tatsuro Takano, Yasuo Terauchi, Kouichi Tamura, Toshimasa Yamauchi, Masaomi Nangaku, Naoki Kashihara, Kazuhiko Ohe

    NPJ digital medicine   7 ( 1 )   155 - 155   2024.6

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  • Effectiveness of DialBetesPlus, a self-management support system for diabetic kidney disease: Randomized controlled trial. International journal

    Kayo Waki, Mitsuhiko Nara, Syunpei Enomoto, Makiko Mieno, Eiichiro Kanda, Akiko Sankoda, Yuki Kawai, Kana Miyake, Hiromichi Wakui, Yuya Tsurutani, Nobuhito Hirawa, Tadashi Yamakawa, Shiro Komiya, Akihiro Isogawa, Shinobu Satoh, Taichi Minami, Tamio Iwamoto, Tatsuro Takano, Yasuo Terauchi, Kouichi Tamura, Toshimasa Yamauchi, Masaomi Nangaku, Naoki Kashihara, Kazuhiko Ohe

    NPJ digital medicine   7 ( 1 )   104 - 104   2024.4

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    We evaluated the effectiveness of a mobile health (mHealth) intervention for diabetic kidney disease patients by conducting a 12-month randomized controlled trial among 126 type 2 diabetes mellitus patients with moderately increased albuminuria (urinary albumin-to-creatinine ratio (UACR): 30-299 mg/g creatinine) recruited from eight clinical sites in Japan. Using a Theory of Planned Behavior (TPB) behavior change theory framework, the intervention provides patients detailed information in order to improve patient control over exercise and dietary behaviors. In addition to standard care, the intervention group received DialBetesPlus, a self-management support system allowing patients to monitor exercise, blood glucose, diet, blood pressure, and body weight via a smartphone application. The primary outcome, change in UACR after 12 months (used as a surrogate measure of renal function), was 28.8% better than the control group's change (P = 0.029). Secondary outcomes also improved in the intervention group, including a 0.32-point better change in HbA1c percentage (P = 0.041). These improvements persisted when models were adjusted to account for the impacts of coadministration of drugs targeting albuminuria (GLP-1 receptor agonists, SGLT-2 inhibitors, ACE inhibitors, and ARBs) (UACR: -32.3% [95% CI: -49.2%, -9.8%] between-group difference in change, P = 0.008). Exploratory multivariate regression analysis suggests that the improvements were primarily due to levels of exercise. This is the first trial to show that a lifestyle intervention via mHealth achieved a clinically-significant improvement in moderately increased albuminuria.

    DOI: 10.1038/s41746-024-01114-8

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  • ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population. International journal

    Yusuke Kobayashi, Keisuke Yatsu, Aiko Haruna, Rina Kawano, Moe Ozawa, Tatsuya Haze, Shiro Komiya, Shota Suzuki, Yuki Ohki, Akira Fujiwara, Sanae Saka, Nobuhito Hirawa, Yoshiyuki Toya, Kouichi Tamura

    Journal of clinical hypertension (Greenwich, Conn.)   26 ( 4 )   355 - 362   2024.4

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    Single-nucleotide polymorphisms (SNP) of ATP2B1 gene are associated with essential hypertension but their association with resistant hypertension (RHT) remains unexplored. The authors examined the relationship between ATP2B1 SNPs and RHT by genotyping 12 SNPs in ATP2B1 gene of 1124 Japanese individuals with lifestyle-related diseases. Patients with RHT had inadequate blood pressure (BP) control using three antihypertensive drugs or used ≥4 antihypertensive drugs. Patients with controlled hypertension had BP controlled using ≤3 antihypertensive drugs. The association between each SNP and RHT was analyzed by logistic regression. The final cohort had 888 (79.0%) and 43 (3.8%) patients with controlled hypertension and RHT, respectively. Compared with patients homozygous for the minor allele of each SNP in ATP2B1, a significantly higher number of patients carrying the major allele at 10 SNPs exhibited RHT (most significant at rs1401982: 5.8% vs. 0.8%, p = .014; least significant at rs11105378: 5.7% vs. 0.9%, p = .035; most nonsignificant at rs12817819: 5.1% vs. 10%, p = .413). After multivariate adjustment for age, sex, systolic BP, and other confounders, the association remained significant for rs2681472 and rs1401982 (OR: 7.60, p < .05 and OR: 7.62, p = .049, respectively). Additionally, rs2681472 and rs1401982 were in linkage disequilibrium with rs11105378. This study identified two ATP2B1 SNPs associated with RHT in the Japanese population. rs1401982 was most closely associated with RHT, and major allele carriers of rs1401982 required significantly more antihypertensive medications. Analysis of ATP2B1 SNPs in patients with hypertension can help in early prediction of RHT and identification of high-risk patients who are more likely to require more antihypertensive medications.

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  • Efficacy of StepAdd, a Personalized mHealth Intervention Based on Social Cognitive Theory to Increase Physical Activity Among Patients With Type 2 Diabetes Mellitus: Protocol for a Randomized Controlled Trial. International journal

    Kayo Waki, Yuya Tsurutani, Hironori Waki, Syunpei Enomoto, Kosuke Kashiwabara, Akira Fujiwara, Kazuki Orime, Sho Kinguchi, Toshimasa Yamauchi, Nobuhito Hirawa, Kouichi Tamura, Yasuo Terauchi, Masaomi Nangaku, Kazuhiko Ohe

    JMIR research protocols   13   e53514   2024.2

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    BACKGROUND: Increasing physical activity improves glycemic control in patients with type 2 diabetes (T2D). Mobile health (mHealth) interventions have been proven to increase exercise, but engagement often fades with time. As the use of health behavior theory in mHealth design can increase effectiveness, we developed StepAdd, an mHealth intervention based on the constructs of social cognitive theory (SCT). StepAdd improves exercise behavior self-efficacy and self-regulation through the use of goal-setting, barrier-identifying, and barrier-coping strategies, as well as automatic feedback functions. A single-arm pilot study of StepAdd among 33 patients with T2D showed a large increase in step count (mean change of 4714, SD 3638 daily steps or +86.7%), along with strong improvements in BMI (mean change of -0.3 kg/m2) and hemoglobin A1c level (mean change of -0.79 percentage points). OBJECTIVE: In this study, we aim to investigate the efficacy and safety of StepAdd, an mHealth exercise support system for patients with T2D, via a large, long, and controlled follow-up to the pilot study. METHODS: This is a randomized, open-label, multicenter study targeting 160 patients with T2D from 5 institutions in Japan with a 24-week intervention. The intervention group will record daily step counts, body weight, and blood pressure using the SCT-based mobile app, StepAdd, and receive feedback about these measurements. In addition, they will set weekly step count goals, identify personal barriers to walking, and define strategies to overcome these barriers. The control group will record daily step counts, body weight, and blood pressure using a non-SCT-based placebo app. Both groups will receive monthly consultations with a physician who will advise patients regarding lifestyle modifications and use of the app. The 24-week intervention period will be followed by a 12-week observational period to investigate the sustainability of the intervention's effects. The primary outcome is between-group difference in the change in hemoglobin A1c values at 24 weeks. The secondary outcomes include other health measures, measurements of steps, measurements of other behavior changes, and assessments of app use. The trial began in January 2023 and is intended to be completed in December 2025. RESULTS: As of September 5, 2023, we had recruited 44 patients. We expect the trial to be completed by October 8, 2025, with the follow-up observation period being completed by December 31, 2025. CONCLUSIONS: This trial will provide important evidence about the efficacy of an SCT-based mHealth intervention in improving physical activities and glycemic control in patients with T2D. If this study proves the intervention to be effective and safe, it could be a key step toward the integration of mHealth as part of the standard treatment received by patients with T2D in Japan. TRIAL REGISTRATION: Japan Registry of Clinical Trials (JRCT) jRCT2032220603; https://rctportal.niph.go.jp/en/detail?trial_id=jRCT2032220603. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/53514.

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  • Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle-Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study. International journal

    Yusuke Kobayashi, Tetsuya Fujikawa, Aiko Haruna, Rina Kawano, Moe Ozawa, Tatsuya Haze, Shiro Komiya, Shota Suzuki, Yuki Ohki, Akira Fujiwara, Sanae Saka, Nobuhito Hirawa, Yoshiyuki Toya, Kouichi Tamura

    Medicina (Kaunas, Lithuania)   60 ( 1 )   2023.12

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    Background and Objectives: Omega-3 fatty acids have potent lipid-lowering and antiplatelet effects; however, randomized controlled trials have yet to examine the effect of high-dose omega-3 fatty acid administration on peripheral artery disease (PAD) in hemodialysis patients with dyslipidemia. Therefore, this study aimed to evaluate the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the ankle-brachial index (ABI) and remnant-like lipoprotein cholesterol (RLP-C) levels, which are indicators of PAD severity. Materials and Methods: Thirty-eight participants (mean age: 73.6 ± 12.7 years) were randomly assigned using stratified block randomization to either conventional therapy alone or conventional therapy supplemented with high-dose EPA/DHA (EPA: 1860 mg; DHA: 1500 mg) for a three-month intervention period. Patients in the conventional therapy alone group who opted to continue were provided with a low-dose EPA/DHA regimen (EPA: 930 mg; DHA: 750 mg) for an additional three months. The baseline and 3-month values for RLP-C, an atherogenic lipid parameter, and the ABI were recorded. Results: The results of the 3-month assessments revealed that the mean RLP-C changes were -3.25 ± 3.15 mg/dL and 0.44 ± 2.53 mg/dL in the EPA/DHA and control groups, respectively (p < 0.001), whereas the changes in the mean ABI values were 0.07 ± 0.11 and -0.02 ± 0.09 in the EPA/DHA and control groups, respectively (p = 0.007). In the EPA/DHA group, a significant negative correlation was found between the changes in RLP-C levels and the ABI (r = -0.475, p = 0.04). Additionally, the change in the RLP-C levels independently influenced the change in the ABI in the EPA/DHA group, even after adjusting for age, sex, and statin use (p = 0.042). Conclusions: Add-on EPA/DHA treatment improved the effectiveness of conventional therapy (such as statin treatment) for improving the ABI in hemodialysis patients with dyslipidemia by lowering RLP-C levels. Therefore, clinicians involved in dialysis should focus on RLP-C when considering residual cardiovascular disease risk in hemodialysis patients and should consider screening patients with elevated levels.

    DOI: 10.3390/medicina60010075

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  • Influence on the accuracy in ChatGPT: Differences in the amount of information per medical field. International journal

    Tatsuya Haze, Rina Kawano, Hajime Takase, Shota Suzuki, Nobuhito Hirawa, Kouichi Tamura

    International journal of medical informatics   180   105283 - 105283   2023.12

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    OBJECTIVES: Although ChatGPT was not developed for medical use, there is growing interest in its use in medical fields. Understanding its capabilities and precautions for its use in the medical field is an urgent matter. We hypothesized that differences in the amounts of information published in different medical fields would be proportionate to the amounts of training ChatGPT receives in those fields, and hence its accuracy in providing answers. STUDY DESIGN: A non-clinical experimental study. METHODS: We administered the Japanese National Medical Examination to GPT-3.5 and GPT-4 to examine the rates of accuracy and consistency in their responses. We counted the total number of documents in the Web of Science Core Collection per medical field and assessed the relationship with ChatGPT's accuracy. We also performed multivariate-adjusted models to investigate the risk factors for incorrect answers. RESULTS: For GPT-4, we confirmed an accuracy rate of 81.0 % and a consistency rate of 88.8 % on the exam; both showed improvement compared to those for GPT-3.5. A positive correlation was observed between the accuracy rate and consistency rate (R = 0.51, P < 0.001). The number of documents per medical field was significantly correlated with the accuracy rate in that medical field (R = 0.44, P < 0.05), with relatively few publications being an independent risk factor for incorrect answers. CONCLUSIONS: Checking consistency may help identify incorrect answers when using ChatGPT. Users should be aware that the accuracy of the answers by ChatGPT may decrease when it is asked about topics with limited published information, such as new drugs and diseases.

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  • 血液透析患者における新型コロナワクチン接種後の抗スパイク蛋白IgG抗体価の経時的推移の検討

    金井 大輔, 涌井 広道, 土師 達也, 花岡 正哲, 三橋 洋, 渡邉 文雅, 平和 伸仁, 戸谷 義幸, 大西 俊正, 田村 功一

    日本透析医学会雑誌   56 ( Suppl.1 )   464 - 464   2023.5

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  • 血液透析患者における新型コロナワクチン接種後の抗スパイク蛋白IgG抗体価の経時的推移の検討

    金井 大輔, 涌井 広道, 土師 達也, 花岡 正哲, 三橋 洋, 渡邉 文雅, 大西 俊正, 平和 伸仁, 戸谷 義幸, 田村 功一

    日本腎臓学会誌   65 ( 3 )   285 - 285   2023.5

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  • Effect of the interaction between the visceral-to-subcutaneous fat ratio and aldosterone on cardiac function in patients with primary aldosteronism

    Tatsuya Haze, Moe Ozawa, Rina Kawano, Aiko Haruna, Yuki Ohki, Shota Suzuki, Yusuke Kobayashi, Akira Fujiwara, Sanae Saka, Kouichi Tamura, Nobuhito Hirawa

    HYPERTENSION RESEARCH   46 ( 5 )   1132 - 1144   2023.5

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    DOI: 10.1038/s41440-023-01170-9

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  • 血液透析患者における新型コロナワクチン接種後の抗スパイク蛋白IgG抗体価の経時的推移の検討

    金井 大輔, 涌井 広道, 土師 達也, 花岡 正哲, 三橋 洋, 渡邉 文雅, 大西 俊正, 平和 伸仁, 戸谷 義幸, 田村 功一

    日本腎臓学会誌   65 ( 3 )   285 - 285   2023.5

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  • 血液透析患者における新型コロナワクチン接種後の抗スパイク蛋白IgG抗体価の経時的推移の検討

    金井 大輔, 涌井 広道, 土師 達也, 花岡 正哲, 三橋 洋, 渡邉 文雅, 平和 伸仁, 戸谷 義幸, 大西 俊正, 田村 功一

    日本透析医学会雑誌   56 ( Suppl.1 )   464 - 464   2023.5

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  • The implication of calf circumference and grip strength in osteoporosis and bone mineral density among hemodialysis patients

    Moe Ozawa, Nobuhito Hirawa, Tatsuya Haze, Aiko Haruna, Rina Kawano, Shiro Komiya, Yuki Ohki, Shota Suzuki, Yusuke Kobayashi, Akira Fujiwara, Sanae Saka, Masaaki Hanaoka, Hiroshi Mitsuhashi, Satoshi Yamaguchi, Toshimasa Ohnishi, Kouichi Tamura

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   27 ( 4 )   365 - 373   2023.4

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    DOI: 10.1007/s10157-022-02308-8

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  • Blunted humoral immune response to the fourth dose of BNT162b2 COVID-19 vaccine in patients undergoing hemodialysis

    Daisuke Kanai, Hiromichi Wakui, Masaaki Hanaoka, Tatsuya Haze, Kengo Azushima, Satoru Shinoda, Shunichiro Tsukamoto, Shinya Taguchi, Sho Kinguchi, Tomohiko Kanaoka, Yoshiyuki Toya, Nobuhito Hirawa, Hideaki Kato, Fumimasa Watanabe, Kanako Hanaoka, Hiroshi Mitsuhashi, Satoshi Yamaguchi, Toshimasa Ohnishi, Kouichi Tamura

    Clinical and Experimental Nephrology   2023.3

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    DOI: 10.1007/s10157-023-02342-0

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  • 原発性アルドステロン症における内臓・皮下脂肪組織量比と血漿アルドステロン濃度の腎機能障害に対する相乗的作用の検討

    土師 達也, 平和 伸仁, 田村 功一

    日本内分泌学会雑誌   98 ( 4 )   911 - 911   2023.2

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  • Clinical impact of left ventricular systolic dysfunction in patients undergoing dialysis access surgery

    Sanae Saka, Masaaki Konishi, Daisuke Kamimura, Hiromichi Wakui, Yasushi Matsuzawa, Kozo Okada, Jin Kirigaya, Noriaki Iwahashi, Teruyasu Sugano, Tomoaki Ishigami, Nobuhito Hirawa, Kiyoshi Hibi, Toshiaki Ebina, Kazuo Kimura, Kouichi Tamura

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   2023.2

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    DOI: 10.1007/s10157-023-02323-3

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  • Improved Immune Response to the Third COVID-19 mRNA Vaccine Dose in Hemodialysis Patients. International journal

    Daisuke Kanai, Hiromichi Wakui, Tatsuya Haze, Kengo Azushima, Sho Kinguchi, Tomohiko Kanaoka, Yoshiyuki Toya, Nobuhito Hirawa, Hideaki Kato, Kazushi Uneda, Fumimasa Watanabe, Kanako Hanaoka, Masaaki Hanaoka, Hiroshi Mitsuhashi, Satoshi Yamaguchi, Toshimasa Ohnishi, Kouichi Tamura

    Kidney international reports   7 ( 12 )   2718 - 2721   2022.12

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    DOI: 10.1016/j.ekir.2022.09.005

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  • The efficacy and safety of mizoribine for maintenance therapy in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis: the usefulness of serum mizoribine monitoring.

    Kaori Mase, Chie Saito, Joichi Usui, Yoshihiro Arimura, Kosaku Nitta, Takashi Wada, Hirofumi Makino, Eri Muso, Nobuhito Hirawa, Masaki Kobayashi, Wako Yumura, Shouichi Fujimoto, Naoki Nakagawa, Takafumi Ito, Yukio Yuzawa, Seiichi Matsuo, Kunihiro Yamagata

    Clinical and experimental nephrology   26 ( 11 )   1092 - 1099   2022.11

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    BACKGROUND: The life prognosis of elderly patients with myeloperoxidase-anti-neutrophil cytoplasmic antibodies-associated vasculitis (MPO-AAV) has been improved by reducing the corticosteroid or cyclophosphamide dose to avoid opportunistic infection. However, many elderly MPO-AAV patients experience recurrence and renal death. An effective and safer maintenance treatment method is necessary to improve the renal prognosis of MPO-AAV. METHODS: Patients with MPO-AAV who reached complete or incomplete remission after induction therapy were prospectively and randomly divided into mizoribine (MZR; n = 25) and control (n = 28) groups. The primary endpoint was relapse of MPO-AAV. The patients' serum MZR concentration was measured before (C0) and 3 h after taking the MZR. The maximum drug concentration (Cmax) and the serum MZR concentration curves were determined using population pharmacokinetics parameters. We also assessed the relationship between the MZR concentrations and adverse events. The observation period was 12 months. RESULTS: Fifty-eight MPO-AAV patients from 16 hospitals in Japan were enrolled. Ten patients relapsed (MZR group, n = 6; control group, n = 4; a nonsignificant between-group difference). Changes in the serum MZR concentration could be estimated for 22 of the 25 MZR-treated patients: 2 of the 11 patients who reached a Cmax of 3 μg/mL relapsed, whereas 4 of the 11 patients who did not reach this Cmax relapsed. The treatment of one patient with C0 > 1 μg/mL was discontinued due to adverse events. No serious adverse events occurred. CONCLUSION: There was no significant difference in the recurrence rate of MPO-AAV between treatment with versus without MZR.

    DOI: 10.1007/s10157-022-02253-6

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  • SARS-CoV-2 spike protein antibody titers 6 months after SARS-CoV-2 mRNA vaccination among patients undergoing hemodialysis in Japan.

    Daisuke Kanai, Hiromichi Wakui, Tatsuya Haze, Kengo Azushima, Sho Kinguchi, Shunichiro Tsukamoto, Tomohiko Kanaoka, Shingo Urate, Yoshiyuki Toya, Nobuhito Hirawa, Hideaki Kato, Fumimasa Watanabe, Kanako Hanaoka, Masaaki Hanaoka, Hiroshi Mitsuhashi, Satoshi Yamaguchi, Toshimasa Ohnishi, Kouichi Tamura

    Clinical and experimental nephrology   26 ( 10 )   988 - 996   2022.6

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    BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is shown to prevent severe illness and death in hemodialysis (HD) patients, but the immune response to vaccines is reduced in this population. This study compared SARS-CoV-2 spike protein antibody titers between HD patients and healthy controls in Japan for up to 6 months following vaccination. METHODS: A multi-institutional retrospective study at five clinics in Japan was conducted using 412 HD patients and 156 healthy controls who received two doses of the BNT162b2 (Pfizer-BioNTech) mRNA vaccine. Anti-SARS-CoV-2 spike protein S1 IgG antibody titers were measured at 1, 3, and 6 months after the second dose. The attenuation speed was calculated as slope (i.e., -β) using a linear mixed-effects model toward the log-transformed antibody titers. RESULTS: The HD group had significantly lower month 1 antibody titers (Ab-titer-1) than the controls, and these remained lower through month 6 (95% CI: 2617.1 (1296.7, 5240.8) vs. 7285.4 (4403.9, 11,000.0) AU/mL at Ab-titer-1, and 353.4 (178.4, 656.3) vs. 812.0 (498.3, 1342.7) AU/mL at Ab-titer-6 (p < 0.001, respectively)). Lower log Ab-titer-1 levels in the HD group were significantly associated with a lower log Ab-titer-6 (0.90 [0.83, 0.97], p < 0.001). The -β values in the HD patients and healthy controls were -4.7 ± 1.1 and -4.7 ± 1.4 (year-1), respectively. CONCLUSION: SARS-CoV-2 spike protein antibody titers were significantly lower in HD patients than in healthy controls at 1 (peak) and 6 months after the second vaccination. Low peak antibody titers contributed to low 6-month antibody titers.

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  • 維持血液透析患者の慢性心不全に対してARNIが有効であった一例

    横山 健一, 鈴木 将太, 長山 尚平, 中山 泉, 小澤 萌枝, 河野 梨奈, 土師 達也, 神山 秋奈, 古宮 士朗, 大城 由紀, 藤原 亮, 坂 早苗, 平和 伸仁

    日本透析医学会雑誌   55 ( Suppl.1 )   652 - 652   2022.5

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  • Efficacy of tolvaptan on advanced chronic kidney disease with heart failure: a randomized controlled trial Reviewed

    Komiya, S, Katsumata, M, Ozawa, M, Haze, T, Kawano, R, Ohki, Y, Suzuki, S, Kobayashi, Y, Fujiwara, A, Saka, S, Tamura, K, Hirawa, N

    Clin Exp Nephrol   26 ( 9 )   851 - 858   2022.4

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    BACKGROUND: Tolvaptan (TLV) is reported to improve diuretic effects in patients with chronic kidney disease (CKD) when furosemide (FUR) is not sufficiently effective. However, it is not clear whether TLV addition is effective for advanced CKD patients with heart failure. METHODS: An open-label, parallel-group randomized trial was performed. The subjects were 33 patients with CKD stage G3-G5 who had fluid overload despite taking 20-100 mg/day FUR. They were divided into two groups: a group administered 15 mg/day TLV plus their original FUR dose for 7 days (TLV group), and a group administered 120-200 mg/day FUR (i.e., 100 mg/day over their previous dose) for 7 days (FUR group). RESULTS: The mean change in urine volume was significantly higher in the TLV group compared to the FUR group (637 ml vs 119 ml; p < 0.05). The difference was greater when the urine osmolality before treatment was high. Serum creatinine was increased only in the FUR group. The incidence of worsening renal function (WRF) was significantly lower in the TLV group (18.8% vs 58.8%; p < 0.05). Serum sodium decreased significantly in the FUR group, but did not change in the TLV group. CONCLUSIONS: In patients with advanced CKD with fluid overload, the addition of TLV achieved a significantly higher urine volume with less adverse effects on renal function compared with increasing the dose of FUR. The efficacy and safety of TLV were higher in patients who had higher urine osmolality and lower serum sodium before treatment. CLINICAL TRIAL REGISTRATION: UMIN000014763.

    DOI: 10.1007/s10157-022-02224-x

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  • LPIN1 is a new target gene for essential hypertension. International journal

    Akira Fujiwara, Moe Ozawa, Koichiro Sumida, Nobuhito Hirawa, Keisuke Yatsu, Nao Ichihara, Tatsuya Haze, Shiro Komiya, Yuki Ohki, Yusuke Kobayashi, Hiromichi Wakui, Kouichi Tamura

    Journal of hypertension   40 ( 3 )   536 - 543   2022.3

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    BACKGROUND: We previously showed Lipin1 (LPIN1) to be a candidate gene for essential hypertension by genome-wide association studies. LPIN1 encodes the Lipin 1 protein, which contributes to the maintenance of lipid metabolism and glucose homeostasis. However, little is known about the association between LPIN1 and blood pressure (BP). METHODS: We evaluated the BP of LPIN1-deficient [fatty liver dystrophy (fld)] mice and explored related mechanisms. RESULTS: Fld mice have very low expression of LPIN1 and exhibit fatty liver, hypertriglyceridemia, insulin resistance and peripheral neuropathy. Fld mice had significantly elevated SBP and heart rate (HR) throughout the day as measured by a radiotelemetric method. Diurnal variation of SBP and HR was also absent in fld mice. Furthermore, urinary excretion of adrenaline and noradrenaline by fld mice was significantly higher compared with that of control mice. The BP response of fld mice to clonidine (a centrally acting α2-adrenergic receptor agonist) was greater than that of control mice. However, levels of Angiotensinogen and Renin 1 mRNA and urinary nitric oxide excretion were comparable between the two groups. The decrease in SBP at 8 weeks after fat grafting surgery was significantly greater in the transplant group compared with the sham operated group. CONCLUSION: The elevated BP in fld mice may result from activation of the sympathetic nervous system through decreased levels of adipose cytokines. These results indicate that LPIN1 plays a crucial role in blood pressure regulation and that LPIN1 is a new target gene for essential hypertension.

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  • Present status of renal replacement therapy in lower-middle-income Asian countries: Cambodia, Myanmar, Laos, Vietnam, Mongolia, and Bhutan as of June 2019 (before COVID-19), from the interviews of leading doctors in every country: (duplicated English publication from "the special Japanese edition of educational lectures in the 64th annual meeting of the Japanese Society for Dialysis Therapy"). Reviewed International journal

    Toru Hyodo, Akihiro C Yamashita, Nobuhito Hirawa, Yoshitaka Isaka, Hidetomo Nakamoto, Takashi Shigematsu

    Renal replacement therapy   8 ( 1 )   54 - 54   2022

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    The present status of Cambodia, Myanmar, Laos, Vietnam, Mongolia, and Bhutan as of June 2019 was reviewed from the interviews of leading doctors in every country. The timing was until just 6 months before the COVID-19 pandemic broke out. The cost per hemodialysis session was 25-70 US dollar and expensive if it is compared with average monthly income of every country. In Cambodia and Laos, patients must cover 100% of expenses for maintenance hemodialysis, in Myanmar, the government covers the cost of once-weekly dialysis sessions, in Vietnam, the government covers 80% of the cost, and in Mongolia and Bhutan, the cost is fully covered by the government. Continuous ambulatory peritoneal dialysis was widely available in Vietnam and Mongolia, which have achieved a relative standard of social infrastructure, but is far from common in any of the other countries. The number of patients on dialysis is increasing with economic development in all countries. Diabetic nephropathy is a common primary reason for dialysis. None of the countries discussed in this article had clinical engineers who could maintain hemodialysis equipment and carry out clinical tasks in dialysis centers. Hospitals were not maintaining their equipment, and damaged units were kept in storage to be used for spare parts. None of the countries had dieticians to provide patients with dietary guidance. Establishment and training of both clinical engineers and registered dietitians are major projects that must be undertaken.

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  • 原発性アルドステロン症における腹部内臓脂肪の重要性 腎障害に対するアルドステロンと内臓脂肪組織の相乗的作用

    土師 達也, 平和 伸仁

    循環器内科   90 ( 6 )   682 - 688   2021.12

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  • 発症8年後に再生検を行ったフィブロネクチン腎症の一例

    稲葉 彩, 出崎 緑, 出来 沙織, 内村 暢, 坂 早苗, 平和 伸仁, 千葉 佐和子, 大谷 方子, 伊藤 秀一, 大坪 裕美, 野津 寛大, 城 謙輔

    日本小児腎臓病学会雑誌   34 ( 2 )   188 - 189   2021.11

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  • 発症8年後に再生検を行ったフィブロネクチン腎症の一例

    稲葉 彩, 出崎 緑, 出来 沙織, 内村 暢, 坂 早苗, 平和 伸仁, 千葉 佐和子, 大谷 方子, 伊藤 秀一, 大坪 裕美, 野津 寛大, 城 謙輔

    日本小児腎臓病学会雑誌   34 ( 2 )   188 - 189   2021.11

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  • Association of the ratio of visceral-to-subcutaneous fat volume with renal function among patients with primary aldosteronism. Reviewed International journal

    Tatsuya Haze, Moe Hatakeyama, Shiro Komiya, Rina Kawano, Yuki Ohki, Shota Suzuki, Yusuke Kobayashi, Akira Fujiwara, Sanae Saka, Kouichi Tamura, Nobuhito Hirawa

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 10 )   1341 - 1351   2021.10

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    Patients with primary aldosteronism have a higher risk of chronic kidney disease. Visceral fat tissue is hypothesized to stimulate the adrenal glands to overproduce aldosterone, and aldosterone promotes visceral fat tissue to produce inflammatory cytokines. However, it is unclear whether the volume of accumulated visceral fat tissue is associated with renal impairment among patients with hyperaldosteronism. We conducted a single-center cross-sectional study to assess the association between the estimated glomerular filtration rate and the ratio of the visceral-to-subcutaneous fat volume calculated by computed tomography. One hundred eighty patients with primary aldosteronism were enrolled. The mean ± SD age was 52.7 ± 11.0 years, and 60.0% were women. The ratio of visceral-to-subcutaneous fat volume was highly correlated with the estimated glomerular filtration rate (r = 0.49, p < 0.001). In multiple linear regression models, the ratio of visceral-to-subcutaneous fat tissue volume was significantly associated with the estimated glomerular filtration rate (estimates: -4.56 mL/min/1.73 m² per 1-SD), and there was an interaction effect between the plasma aldosterone concentration and the ratio of visceral-to-subcutaneous fat volume (p < 0.05). The group with a higher plasma aldosterone concentration exhibited a steeper decline in eGFR than the lower plasma aldosterone concentration group when the ratio increased. The ratio of visceral-to-subcutaneous fat tissue volume was an independent risk factor for renal dysfunction. This association increased in the presence of a high plasma aldosterone concentration. Clinicians should pay attention to the ratio of visceral-to-subcutaneous fat tissue volume and encourage primary aldosteronism patients to improve their lifestyle in addition to treating renin-aldosterone activity.

    DOI: 10.1038/s41440-021-00719-w

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  • Efficacy of the Self-management Support System DialBetesPlus for Diabetic Kidney Disease: Protocol for a Randomized Controlled Trial. International journal

    Yuki Kawai, Akiko Sankoda, Kayo Waki, Kana Miyake, Aki Hayashi, Makiko Mieno, Hiromichi Wakui, Yuya Tsurutani, Jun Saito, Nobuhito Hirawa, Tadashi Yamakawa, Shiro Komiya, Akihiro Isogawa, Shinobu Satoh, Taichi Minami, Uru Osada, Tamio Iwamoto, Tatsuro Takano, Yasuo Terauchi, Kouichi Tamura, Toshimasa Yamauchi, Takashi Kadowaki, Masaomi Nangaku, Naoki Kashihara, Kazuhiko Ohe

    JMIR research protocols   10 ( 8 )   e31061   2021.8

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    BACKGROUND: Diabetic kidney disease (DKD) is one of the main complications of type 2 diabetes mellitus (T2DM). DKD is a known risk factor for end-stage renal disease, cardiovascular disease, and all-cause death. Effective intervention for early-stage DKD is vital to slowing down the progression of kidney disease and improve prognoses. Mobile health (mHealth) is reportedly effective in supporting patients' self-care and improving glycemic control, but the impact of mHealth on DKD has yet to be shown. OBJECTIVE: The purpose of this study is to evaluate the efficacy of standard therapy with the addition of a self-management support system, DialBetesPlus, in patients with DKD and microalbuminuria. METHODS: This study is a prospective, randomized, open-label, multicenter clinical trial. The target population consists of 160 patients diagnosed with T2DM accompanied by microalbuminuria. We randomly assigned the patients to 2 groups-the intervention group using DialBetesPlus in addition to conventional therapy and the control group using conventional therapy alone. DialBetesPlus is a smartphone application that supports patients' self-management of T2DM. The study period was 12 months, with a follow-up survey at 18 months. The primary outcome was a change in albuminuria levels at 12 months. Secondary outcomes included changes in physical parameters, blood test results (glycemic control, renal function, and lipid metabolism), lifestyle habits, self-management scores, medication therapy, and quality of life. RESULTS: The study was approved in April 2018. We began recruiting patients in July 2018 and completed recruiting in August 2019. The final 18-month follow-up was conducted in March 2021. We recruited 159 patients and randomly allocated 70 into the intervention group and 61 into the control group, with 28 exclusions due to withdrawal of consent, refusal to continue, or ineligibility. The first results are expected to be available in 2021. CONCLUSIONS: This is the first randomized controlled trial assessing the efficacy of mHealth on early-stage DKD. We expect that albuminuria levels will decrease significantly in the intervention group due to improved glycemic control with ameliorated self-care behaviors. TRIAL REGISTRATION: UMIN-CTR UMIN000033261; https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000037924. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/31061.

    DOI: 10.2196/31061

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  • 血液透析患者における骨密度低下の割合と関連因子の検討

    畠山 萌枝, 藏口 裕美, 亀丸 愛子, 平塚 梨奈, 土師 達也, 古宮 士朗, 大城 由紀, 鈴木 将太, 藤原 亮, 坂 早苗, 三橋 洋, 山口 聡, 大西 俊正, 田村 功一, 平和 伸仁

    日本腎臓学会誌   63 ( 4 )   506 - 506   2021.6

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  • 血液透析患者における骨密度低下の割合と関連因子の検討

    畠山 萌枝, 藏口 裕美, 亀丸 愛子, 平塚 梨奈, 土師 達也, 古宮 士朗, 大城 由紀, 鈴木 将太, 藤原 亮, 坂 早苗, 三橋 洋, 山口 聡, 大西 俊正, 田村 功一, 平和 伸仁

    日本腎臓学会誌   63 ( 4 )   506 - 506   2021.6

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  • 慢性腎臓病におけるトルバプタンの効果についてのランダム化比較試験

    古宮 士朗, 勝又 真理, 蔵口 裕美, 亀丸 愛子, 畠山 萌枝, 平塚 梨奈, 土師 達也, 大城 由紀, 鈴木 将太, 諸宇 旭純, 藤原 亮, 小林 麻裕美, 坂 早苗, 三橋 洋, 田村 功一, 平和 伸仁

    日本腎臓学会誌   63 ( 4 )   508 - 508   2021.6

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  • 原発性アルドステロン症における内臓脂肪組織量・皮下脂肪組織量比と腎機能障害

    土師 達也, 畠山 萌枝, 坂 早苗, 藏口 裕美, 亀丸 愛子, 平塚 梨奈, 古宮 士朗, 大城 由紀, 加納 和代, 小宮 麻里子, 鈴木 将太, 諸宇 旭純, 潘 勤雅, 藤原 亮, 小林 麻裕美, 三橋 洋, 田村 功一, 平和 伸仁

    日本腎臓学会誌   63 ( 4 )   509 - 509   2021.6

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  • 原発性アルドステロン症における内臓脂肪組織量・皮下脂肪組織量比と腎機能障害

    土師 達也, 畠山 萌枝, 坂 早苗, 藏口 裕美, 亀丸 愛子, 平塚 梨奈, 古宮 士朗, 大城 由紀, 加納 和代, 小宮 麻里子, 鈴木 将太, 諸宇 旭純, 潘 勤雅, 藤原 亮, 小林 麻裕美, 三橋 洋, 田村 功一, 平和 伸仁

    日本腎臓学会誌   63 ( 4 )   509 - 509   2021.6

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  • CKD急性増悪および低血圧を呈し病理解剖にて確定診断を得た全身性ALアミロイドーシスの一例

    鈴木 将太, 外澤 真李, 藏口 裕美, 亀丸 愛子, 河野 梨奈, 大城 由紀, 藤原 亮, 坂 早苗, 田中 玲子, 大谷 方子, 稲山 嘉明, 田村 功一, 平和 伸仁

    日本透析医学会雑誌   54 ( Suppl.1 )   347 - 347   2021.5

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  • Association of aldosterone and blood pressure with the risk for cardiovascular events after treatments in primary aldosteronism. Reviewed International journal

    Tatsuya Haze, Nobuhito Hirawa, Yuichiro Yano, Kouichi Tamura, Isao Kurihara, Hiroki Kobayashi, Mika Tsuiki, Takamasa Ichijo, Norio Wada, Takuyuki Katabami, Koichi Yamamoto, Kenji Oki, Nobuya Inagaki, Shintaro Okamura, Tatsuya Kai, Shoichiro Izawa, Masanobu Yamada, Yoshiro Chiba, Akiyo Tanabe, Mitsuhide Naruse

    Atherosclerosis   324   84 - 90   2021.5

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    BACKGROUND AND AIMS: We used a dataset from a Japanese nationwide registry of patients with primary aldosteronism, to determine which of the parameters of hyperaldosteronism and blood pressure before or after treatments for primary aldosteronism (i.e., surgical adrenalectomy or a medication treatment) are important in terms of cardiovascular prognosis. METHODS: We assessed whether plasma aldosterone-to-renin ratio and pulse pressure levels before treatment and 6 months after treatment were associated with composite cardiovascular disease events during the 5-year follow-up period. RESULTS: The cohort included 1987 patients (mean age was 53.2 years, 52.0% were female, 37.2% had undergone surgical treatment, and the remainder had been treated with mineralocorticoid receptor antagonists). In the Cox proportional hazard model, the covariate-adjusted hazard ratio (95% confidence interval) for the composite cardiovascular disease events risk for each one-standard-deviation increase in the aldosterone-to-renin ratio or pulse pressure before treatment, those after treatment, or the duration of hypertension were 1.24 (1.05, 1.48), 0.74 (0.54, 1.02), and 1.07 (0.79, 1.44), 1.43 (1.07, 1.92), and 1.52 (1.19, 1.95), respectively. Patients with a high pre-treatment aldosterone-to-renin ratio of more than 603 and a large post-treatment pulse pressure of more than 49 mmHg showed approximately three-fold higher hazard ratios for cardiovascular events risk compared to those with a lower aldosterone-to-renin ratio and smaller pulse pressure. CONCLUSIONS: Higher aldosterone-to-renin ratio before treatments, higher pulse pressure after treatments, and longer duration of hypertension were prognostic factors for cardiovascular diseases. Early intervention may be important for preventing cardiovascular disease among patients with primary aldosteronism.

    DOI: 10.1016/j.atherosclerosis.2021.03.033

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  • インフルエンザウイルス感染を契機とした横紋筋融解症による急性腎障害の一例

    藤原 亮, 平和 伸仁, 亀丸 愛子, 外澤 真李, 畠山 萌枝, 土師 達也, 古宮 士朗, 鈴木 将太, 坂 早苗, 田村 功一

    日本透析医学会雑誌   53 ( Suppl.1 )   642 - 642   2020.10

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  • Treatment-related damage in elderly-onset ANCA-associated vasculitis: safety outcome analysis of two nationwide prospective cohort studies

    Ken-Ei Sada, Keiji Ohashi, Yosuke Asano, Keigo Hayashi, Michiko Morishita, Haruki Watanabe, Yoshinori Matsumoto, Shouichi Fujimoto, Yoshinari Takasaki, Kunihiro Yamagata, Shogo Banno, Hiroaki Dobashi, Koichi Amano, Masayoshi Harigai, Yoshihiro Arimura, Hirofumi Makino

    ARTHRITIS RESEARCH & THERAPY   22 ( 1 )   2020.10

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    DOI: 10.1186/s13075-020-02341-6

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  • 難治性十二指腸潰瘍を合併した抗GBM抗体型糸球体腎炎の一例

    鈴木 将太, 小野 有加, 亀丸 愛子, 外澤 真李, 畠山 萌枝, 土師 達也, 古宮 士朗, 藤原 亮, 坂 早苗, 田村 功一, 平和 伸仁

    日本透析医学会雑誌   53 ( Suppl.1 )   643 - 643   2020.10

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  • メトホルミン内服中に下痢および敗血症を合併し乳酸アシドーシスを発症した一例

    柴橋 康平, 鈴木 将太, 亀丸 愛子, 外澤 真李, 畠山 萌枝, 土師 達也, 古宮 士朗, 藤原 亮, 坂 早苗, 田村 功一, 平和 伸仁

    日本透析医学会雑誌   53 ( Suppl.1 )   692 - 692   2020.10

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  • 初回の血栓性微小血管症発作で末期腎不全に至った非典型溶血性尿毒症症候群の一症例

    外澤 真李, 藤原 亮, 亀丸 愛子, 畠山 萌枝, 土師 達也, 古宮 士朗, 加納 和代, 小宮 麻里子, 鈴木 将太, 諸宇 旭純, 小林 麻裕美, 坂 早苗, 大谷 方子, 田村 功一, 平和 伸仁

    日本腎臓学会誌   62 ( 6 )   569 - 569   2020.9

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  • MCTD類似病態に対しステロイド加療する中で生じた腎クリーゼの一例

    藏口 裕美, 大城 由紀, 平塚 梨奈, 亀丸 愛子, 鈴木 将太, 藤原 亮, 坂 早苗, 田村 功一, 平和 伸仁

    日本腎臓学会誌   62 ( 6 )   522 - 522   2020.9

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  • プロピルチオウラシルによる薬剤性ANCA関連血管炎によってネフローゼ症候群を発症した一例

    古田 里華, 鈴木 将太, 亀丸 愛子, 藏口 裕美, 畠山 萌枝, 土師 達也, 平塚 梨奈, 古宮 士朗, 大城 由紀, 藤原 亮, 坂 早苗, 田村 功一, 平和 伸仁

    日本腎臓学会誌   62 ( 6 )   587 - 587   2020.9

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  • 梅毒によるネフローゼ症候群に抗生剤加療が奏功した一例

    亀丸 愛子, 畠山 萌枝, 藏口 裕美, 土師 達也, 平塚 梨奈, 古宮 士朗, 大城 由紀, 鈴木 将太, 藤原 亮, 坂 早苗, 大谷 方子, 田村 功一, 平和 伸仁

    日本腎臓学会誌   62 ( 6 )   541 - 541   2020.9

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  • 著明な低K血症および高Na血症を伴った横紋筋融解症の1症例

    宮澤 明子, 鈴木 将太, 亀丸 愛子, 外澤 真李, 畠山 萌枝, 土師 達也, 古宮 士朗, 藤原 亮, 坂 早苗, 平和 伸仁

    日本内科学会関東地方会   655回   34 - 34   2019.11

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  • The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019). Invited International journal

    Satoshi Umemura, Hisatomi Arima, Shuji Arima, Kei Asayama, Yasuaki Dohi, Yoshitaka Hirooka, Takeshi Horio, Satoshi Hoshide, Shunya Ikeda, Toshihiko Ishimitsu, Masaaki Ito, Sadayoshi Ito, Yoshio Iwashima, Hisashi Kai, Kei Kamide, Yoshihiko Kanno, Naoki Kashihara, Yuhei Kawano, Toru Kikuchi, Kazuo Kitamura, Takanari Kitazono, Katsuhiko Kohara, Masataka Kudo, Hiroo Kumagai, Kiyoshi Matsumura, Hideo Matsuura, Katsuyuki Miura, Masashi Mukoyama, Satoko Nakamura, Takayoshi Ohkubo, Yusuke Ohya, Takafumi Okura, Hiromi Rakugi, Shigeyuki Saitoh, Hirotaka Shibata, Tatsuo Shimosawa, Hiromichi Suzuki, Shori Takahashi, Kouichi Tamura, Hirofumi Tomiyama, Takuya Tsuchihashi, Shinichiro Ueda, Yoshinari Uehara, Hidenori Urata, Nobuhito Hirawa

    Hypertension research : official journal of the Japanese Society of Hypertension   42 ( 9 )   1235 - 1481   2019.9

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    DOI: 10.1038/s41440-019-0284-9

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  • 尋常性乾癬および併存する生活習慣病の治療中に薬剤性尿細管間質性腎炎を発症した1例

    外澤 真李, 畠山 萌枝, 土師 達也, 古宮 士朗, 加納 和代, 小宮 麻里子, 鈴木 将太, 諸宇 旭純, 藤原 亮, 小林 麻裕美, 坂 早苗, 大谷 方子, 平和 伸仁, 田村 功一

    日本腎臓学会誌   61 ( 6 )   729 - 729   2019.8

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  • ステロイドが奏功した急性尿細管間質性腎炎の1例

    畠山 萌枝, 坂 早苗, 亀丸 愛子, 外澤 真李, 土師 達也, 古宮 士朗, 鈴木 将太, 藤原 亮, 小林 麻裕美, 大谷 方子, 戸谷 義幸, 田村 功一, 平和 伸仁

    日本腎臓学会誌   61 ( 6 )   721 - 721   2019.8

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  • 有意なカテコラミン過剰分泌を認めなかった褐色細胞腫の一例

    古宮 士朗, 坂 早苗, 外澤 真李, 畠山 萌枝, 土師 達也, 鈴木 将太, 小宮 麻里子, 加納 和代, 諸宇 旭純, 藤原 亮, 小林 麻裕美, 田村 功一, 平和 伸仁

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   8回   186 - 186   2019.5

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  • 当院で経験した加速型-悪性高血圧13例の腎予後の検討

    藤原 亮, 坂 早苗, 外澤 真李, 畠山 萌枝, 土師 達也, 古宮 士朗, 鈴木 将太, 田村 功一, 平和 伸仁

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   8回   159 - 159   2019.5

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  • 副腎皮質癌による原発性アルドステロン症の一例と当院におけるアルドステロン症診断・治療の現状

    坂 早苗, 外澤 真李, 畠山 萌枝, 土師 達也, 古宮 士朗, 鈴木 将太, 藤原 亮, 戸谷 義幸, 田村 功一, 平和 伸仁

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   8回   177 - 177   2019.5

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  • LDLアフェレシス及び多剤の免疫抑制剤を必要とした難治性ネフローゼ症候群の1例

    畠山 萌枝, 坂 早苗, 外澤 真李, 土師 達也, 古宮 士朗, 加納 和代, 小宮 麻里子, 鈴木 将太, 諸宇 旭純, 藤原 亮, 小林 麻裕美, 潘 勤雅, 戸谷 義幸, 田村 功一, 平和 伸仁

    日本透析医学会雑誌   52 ( Suppl.1 )   630 - 630   2019.5

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  • ATP2B1遺伝子の一塩基多型は治療抵抗性高血圧と関連する

    小林 雄祐, 平和 伸仁, 土師 達也, 古宮 士朗, 角田 剛一郎, 鍵本 美奈子, 鈴木 将太, 大城 由紀, 江原 洋介, 藤原 亮, 坂 早苗, 谷津 圭介, 小林 英雄, 梅村 敏, 田村 功一

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   8回   144 - 144   2019.5

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  • Viewpoint on Guidelines for Treatment of Hypertension in Japan Invited Reviewed

    Hirawa, N. Umemura, S. Ito, S

    Circ Res   124 ( 7 )   981 - 983   2019.3

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  • Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study. Reviewed

    Kunihiro Yamagata, Joichi Usui, Michio Nagata, Hitoshi Sugiyama, Ken-Ei Sada, Eri Muso, Masayoshi Harigai, Koichi Amano, Tatsuya Atsumi, Shouichi Fujimoto, Yukio Yuzawa, Masaki Kobayashi, Takao Saito, Takafumi Ito, Nobuhito Hirawa, Sakae Homma, Hiroaki Dobashi, Naotaka Tsuboi, Akihiro Ishizu, Yoshihiro Arimura, Hirofumi Makino, Seiichi Matsuo

    Clinical and experimental nephrology   23 ( 3 )   387 - 394   2019.3

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    BACKGROUND: The prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis. METHODS: We collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies. Based on the EUVAS-proposed histopathological classification and some histological parameters, we statistically evaluated renal survival and the comparison of renal function for 2 years. RESULTS: Based on the histopathological classification, the largest number of biopsy samples belonged to the Focal class, followed by the Mixed, Crescentic, and Sclerotic classes (n = 30, 19, 10, 8, respectively). Although the number of events might be too low (four patients with renal death) to make this conclusion, the Focal and Mixed classes had higher renal-survival rates compared to the others in the renal-survival curve. Comparing renal function among all classes, the estimated glomerular filtration rate (eGFR) throughout 2-year follow-up period was significantly higher in the Focal class compared to the other 3 classes. The eGFR-values in the Crescentic, Mixed, and Sclerotic classes increased with time. Based on both combined results, the Focal class could be the best prognosis. CONCLUSION: This histopathological classification was valuable for both the stratification of renal function and the estimation of partial renal survival during 2-year follow-up in ANCA-associated glomerulonephritis.

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  • Blood pressure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies ConferenceKidney Int. Invited Reviewed

    KDIGO WG

    Kidney Int.   95 ( 5 )   1027 - 1036   2019.3

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  • 造血幹細胞移植後に慢性移植片対宿主病と尿蛋白を認め、Transplant-associated thrombotic microangiopathyと考えられた症例

    土師 達也, 大谷 方子, 外澤 真季, 畠山 萌枝, 古宮 士朗, 加納 和代, 小宮 麻里子, 鈴木 将太, 諸宇 旭純, 潘 勤雅, 藤原 亮, 小林 麻裕美, 坂 早苗, 平和 伸仁

    腎炎症例研究   36   1 - 26   2019

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  • A17586 Cardio-ankle vascular index predicts incidence of chronic kidney disease in patients with life-style related disease Reviewed

    Fumika Nishizawa, Yusuke Kobayashi, Hideo Kobayashi, Tetsuya Fujikawa, Tamio Iwamoto, Nobuhito Hirawa, Yoshiyuki Toya, Satoshi Umemura, Kouichi Tamura

    Journal of Hypertension   36   e251   2018.10

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  • A5669 Lower BMI despite of having abdominal obesity is a risk of sarcopenic obesity which shows high arterial stiffness in patients with life-style related disease Reviewed

    Shota Suzuki, Yusuke Kobayashi, Hideo Kobayashi, Tetsuya Fujikawa, Tamio Iwamoto, Nobuhito Hirawa, Yoshiyuki Toya, Satoshi Umemura, Kouichi Tamura

    Journal of Hypertension   36   e170   2018.10

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    DOI: 10.1097/01.hjh.0000548693.27681.44

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  • A14339 Impaired systolic blood pressure recovery after standing is associated with arterial stiffening and baroreceptor dysfunction in patients with life-style related disease Reviewed

    Ryutaro Morita, Yusuke Kobayashi, Hideo Kobayashi, Tetsuya Fujikawa, Tamio Iwamoto, Nobuhito Hirawa, Yoshiyuki Toya, Satoshi Umemura, Kouichi Tamura

    Journal of Hypertension   36   e228   2018.10

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    DOI: 10.1097/01.hjh.0000548931.92288.07

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  • Plasma Cystine Levels and Cardiovascular and All-Cause Mortality in Hemodialysis Patients Reviewed International journal

    Suzuki, S. Shino, M. Fujikawa, T. Itoh, Y. Ueda, E. Hashimoto, T. Kuji, T. Kobayashi, N. Ohnishi, T. Hirawa, N. Tamura, K. Toya

    Ther Apher Dial   22 ( 5 )   476 - 484   2018.10

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    Oxidative stress accelerates the development of cardiovascular disease. Plasma cystine, a thiol oxidative stress marker, is related to several established factors for cardiovascular disease risk and prognosis. Although a comprehensive oxidative stress index is clinically required for hemodialysis patients with high oxidative stress, there are few reports concerning thiol oxidative stress markers predicting their prognosis. We investigated the relationship between plasma amino acids including cystine levels and cardiovascular disease-related and all-cause mortality in 132 maintenance hemodialysis patients. Higher cystine levels were associated with old age, longer hemodialysis duration, hemodialysis-associated hypotension, higher cardiothoracic ratio, higher blood urea nitrogen, and lower ankle-brachial index. Multivariate Cox regression analysis revealed that high plasma cystine was independently related with both cardiovascular disease mortality and all-cause mortality. Thus, high plasma cystine levels predict the prognosis of hemodialysis patients. High cystine levels necessitate a careful investigation for the cause of oxidative stress and comorbidities like vascular injury.

    DOI: 10.1111/1744-9987.12669

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  • 高血圧の遺伝疫学研究が明らかにしたもの ミレニアム・ゲノム・プロジェクト Reviewed

    三木 哲郎, 田原 康玄, 小原 克彦, 今井 潤, 平和 伸仁, 梅村 敏, 上島 弘嗣

    日本高血圧学会総会プログラム・抄録集   41回   SY17 - 3   2018.9

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  • 経皮的冠動脈形成術(PCI)後に末期腎不全となったANCA関連腎炎の1例

    畠山 萌枝, 外澤 真李, 土師 達也, 古宮 士朗, 加納 和代, 小宮 麻里子, 鈴木 将太, 諸宇 旭純, 藤原 亮, 小林 麻裕美, 坂 早苗, 田村 功一, 平和 伸仁

    日本腎臓学会誌   60 ( 6 )   916 - 916   2018.8

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  • Arterial wall hypertrophy is ameliorated by alpha2-adrenergic receptor antagonist or aliskiren in kidneys of angiotensinogen-knockout mice Reviewed

    Nakamori, H. Yoshida, S. I. Ishiguro, H. Suzuki, S. Yasuzaki, H. Hashimoto, T. Ishigami, T. Hirawa, N. Toya, Y. Umemura, S. Tamura, K

    Clin Exp Nephrol   22 ( 4 )   773 - 781   2018.8

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    BACKGROUND: Arterial hypertrophy and interstitial fibrosis are important characteristics in kidneys of angiotensinogen-knockout (Atg -/-) mice. In these mice, which exhibit polyuria and hypotension, sympathetic nerve signaling is estimated to be compensatorily hyperactive. Furthermore, transforming growth factor (TGF)-β1 is overexpressed in mice kidneys. To determine whether sympathetic nerve signaling and TGF-β1 exacerbate arterial hypertrophy and interstitial fibrosis, intervention studies of such signaling are required. METHODS: We performed renal denervation and administered the α2-adrenergic receptor (AR) antagonist, atipamezole, to Atg -/- mice. A renin inhibitor, aliskiren, which was preliminarily confirmed to reduce TGF-β1 gene expression in kidneys of the mice, was additionally administered to assess the effect on the arterial hypertrophy and interstitial fibrosis. RESULTS: Norepinephrine content in kidneys of Atg -/- mice was three times higher than in kidneys of wild-type mice. Interventions by renal denervation and atipamezole resulted in amelioration of the histological findings. Overexpression of TGF-β1 gene in kidneys of Atg -/- mice was altered in a manner linked to the histological findings. Surprisingly, aliskiren reduced α2-AR gene expression, interstitial fibrosis, and arterial hypertrophy in kidneys of Atg -/- mice, which lack renin substrate. CONCLUSIONS: Alpha2-AR signaling is one of the causes of persistent renal arterial hypertrophy in Atg -/- mice. Aliskiren also angiotensinogen-independently reduces the extent of renal arterial hypertrophy, partly thorough downregulation of α2-ARs. Although renal arterial hypertrophy in Atg -/- mice appears to be of multifactorial origin, TGF-β1 may play a key role in the persistence of such hypertrophy.

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  • 常染色体優性多発性嚢胞腎に対するトルバプタン投与中断,再開前後の両腎容積推移

    坂 早苗, 外澤 真李, 畠山 萌枝, 土師 達也, 古宮 士朗, 潘 勤雅, 加納 和代, 小宮 麻里子, 鈴木 将太, 諸宇 旭純, 藤原 亮, 小林 麻裕美, 田村 功一, 平和 伸仁

    日本腎臓学会誌   60 ( 6 )   886 - 886   2018.8

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  • 糖尿病の悪化を契機に発見されたIgG4関連腎臓病の1例

    外澤 真李, 藤原 亮, 畠山 萌枝, 土師 達也, 古宮 士朗, 加納 和代, 小宮 麻里子, 鈴木 将太, 諸宇 旭純, 小林 麻裕美, 坂 早苗, 田村 功一, 平和 伸仁

    日本腎臓学会誌   60 ( 6 )   928 - 928   2018.8

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  • 基底膜の菲薄化と低尿酸血症を認めたネフローゼ症候群の一例

    古宮 士朗, 外澤 真李, 畠山 萌枝, 土師 達也, 加納 和代, 小宮 麻里子, 鈴木 将太, 諸宇 旭純, 藤原 亮, 小林 麻裕美, 坂 早苗, 田村 功一, 大谷 方子, 平和 伸仁

    日本腎臓学会誌   60 ( 6 )   910 - 910   2018.8

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  • Reduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice Reviewed

    Yosuke Ehara, Nobuhito Hirawa, Kouichiro Sumida, Akira Fujiwara, Minako Kagimoto, Yuki Ooki-Okuyama, Megumi Fujita, Mari Katsumata, Yusuke Kobayashi, Sanae Saka, Ikuma Katou, Keisuke Yatsu, Satoshi Umemura, Kouichi Tamura

    Hypertension Research   1 - 9   2018.6

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    DOI: 10.1038/s41440-018-0067-8

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  • 原発性アルドステロン症 診断・治療の最前線 横浜市大関連施設におけるAVS症例をまとめた自験例解析からも見えてくる、PA診断の課題と今後の提案

    谷津 圭介, 小林 雄祐, 坂 早苗, 春原 須美玲, 涌井 広道, 平和 伸仁, 田村 功一

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   7回   150 - 150   2018.5

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  • 原因不明の腎不全、全身痙攣、不明熱、腹膜透析液に対するアレルギーを認め、成人スチル病と診断した症例

    土師 達也, 平和 伸仁, 畠山 萌枝, 古宮 士朗, 森 梓, 加納 和代, 小宮 麻里子, 勝又 真理, 富岡 旭純, 藤原 亮, 小林 麻裕美, 坂 早苗, 安田 元, 田村 功一

    日本透析医学会雑誌   51 ( Suppl.1 )   836 - 836   2018.5

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  • 不明熱と傍大動脈リンパ節腫大を呈し診断に難渋した長期透析患者の一例

    藤原 亮, 平和 伸仁, 畠山 萌枝, 土師 達也, 古宮 士朗, 加納 和代, 小宮 麻里子, 諸宇 旭純, 小林 麻裕美, 坂 早苗, 田村 功一, 安田 元

    日本透析医学会雑誌   51 ( Suppl.1 )   887 - 887   2018.5

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  • 悪性高血圧により急速に腎機能低下進行し、血液透析導入となった症例

    古宮 士朗, 平和 伸仁, 畠山 萌枝, 土師 達也, 小宮 麻里子, 加納 和代, 諸宇 旭純, 藤原 亮, 小林 麻裕美, 坂 早苗, 田村 功一, 安田 元

    日本透析医学会雑誌   51 ( Suppl.1 )   746 - 746   2018.5

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  • 利尿剤濫用により腎機能障害をきたし血液透析導入となった一例

    畠山 萌枝, 平和 伸仁, 土師 達也, 古宮 士朗, 加納 和代, 小宮 麻里子, 諸宇 旭純, 藤原 亮, 小林 麻裕美, 坂 早苗, 田村 功一, 安田 元

    日本透析医学会雑誌   51 ( Suppl.1 )   773 - 773   2018.5

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  • CERA投与下のヘプシジン変動に対する鉄剤投与の影響

    河野 知之, 藤川 哲也, 久慈 忠司, 川井 有紀, 植田 瑛子, 篠 みどり, 佐藤 陽, 三橋 洋, 小川 成章, 小田 寿, 山口 聡, 大西 俊正, 平和 伸仁, 戸谷 義幸, 田村 功一

    日本透析医学会雑誌   51 ( Suppl.1 )   700 - 700   2018.5

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  • 当院においてaHUS(非典型溶血性尿毒症症候群)が疑われた4症例の検討

    藤原 亮, 平和 伸仁, 畠山 萌枝, 土師 達也, 古宮 士朗, 坂 早苗, 田村 功一, 安田 元

    日本腎臓学会誌   60 ( 3 )   451 - 451   2018.4

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  • Atherosclerosis of the carotid bulb is associated with the severity of orthostatic hypotension in non-diabetic adult patients: a cross-sectional study Reviewed International journal

    Kobayashi, Y. Ishiguro, H. Fujikawa, T. Kobayashi, H. Sumida, K. Kagimoto, M. Okuyama, Y. Ehara, Y. Katsumata, M. Fujita, M. Fujiwara, A. Saka, S. Yatsu, K. Hirawa, N. Toya, Y. Yasuda, G. Umemura, S. Tamura, K

    Clin Exp Hypertens   1 - 8   2018.4

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    BACKGROUND: The carotid bulb has a high density of baroreceptors that play an important role in maintaining blood pressure. We hypothesized that atherosclerosis of the carotid bulb would reflect the severity of orthostatic hypotension more accurately than would atherosclerosis of other carotid artery segments. METHODS: This cross-sectional study included 198 non-diabetic adults. We measured the cardio-vascular ankle index as an index of arterial stiffness, intima-media thickness in each carotid artery segment (internal carotid artery, carotid bulb, distal and proximal portions, respectively, of the common carotid artery) as a measure of atherosclerosis, and heart rate variability as a measure of cardiac autonomic function. The sit-to-stand test was used to assess severity of orthostatic hypotension. RESULTS: Intima-media thickness of the carotid bulb was correlated with orthostatic systolic blood pressure change (r = -0.218, p = 0.002), cardio-ankle vascular index (r = 0.365, p < 0.001) and heart rate variability parameters. Multivariate regression analysis revealed that among all of the segments, only intima-media thickness of the carotid bulb was an independent predictor of orthostatic systolic blood pressure change (p = 0.022). CONCLUSION: Atherosclerosis of the carotid bulb was associated with severity of orthostatic hypotension, arterial stiffening and cardiac autonomic dysfunction than that of other carotid artery segments.

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  • The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice Reviewed

    Yuki Okuyama, Nobuhito Hirawa, Megumi Fujita, Akira Fujiwara, Yosuke Ehara, Keisuke Yatsu, Koichiro Sumida, Minako Kagimoto, Mari Katsumata, Yusuke Kobayashi, Sanae Saka, Satoshi Umemura, Kouichi Tamura

    Hypertension Research   41 ( 2 )   80 - 87   2018.2

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    DOI: 10.1038/hr.2017.92

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  • Monozygotic twins discordant for primary aldosteronism: a case report (vol 31, pg 754, 2017) Reviewed

    Y. Kobayashi, K. Yatsu, K. Nakata-Shimokihara, N. Inoue, T. Fujikawa, N. Hirawa, S. Umemura, F. Satoh, G. P. Rossi, K. Tamura

    JOURNAL OF HUMAN HYPERTENSION   31 ( 11 )   760 - 760   2017.11

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    DOI: 10.1038/jhh.2017.53

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  • Monozygotic twins discordant for primary aldosteronism: a case report Reviewed

    Y. Kobayashi, K. Yatsu, K. Nakata-Shimokihara, N. Inoue, T. Fujikawa, N. Hirawa, S. Umemura, F. Satoh, G. P. Rossi, K. Tamura

    JOURNAL OF HUMAN HYPERTENSION   31 ( 11 )   754 - 755   2017.11

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  • Effects of tolvaptan in patients with chronic kidney disease and chronic heart failure Reviewed

    Mari Katsumata, Nobuhito Hirawa, Koichiro Sumida, Minako Kagimoto, Yosuke Ehara, Yuki Okuyama, Megumi Fujita, Akira Fujiwara, Mayumi Kobayashi, Yusuke Kobayashi, Yuichiro Yamamoto, Sanae Saka, Keisuke Yatsu, Tetsuya Fujikawa, Yoshiyuki Toya, Gen Yasuda, Kouichi Tamura, Satoshi Umemura

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   21 ( 5 )   858 - 865   2017.10

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  • Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II-infused mice. Reviewed International journal

    Hiromichi Wakui, Koichiro Sumida, Megumi Fujita, Yuta Ohtomo, Masato Ohsawa, Ryu Kobayashi, Kazushi Uneda, Kengo Azushima, Kotaro Haruhara, Keisuke Yatsu, Nobuhito Hirawa, Shintaro Minegishi, Tomoaki Ishigami, Satoshi Umemura, Kouichi Tamura

    Physiological reports   5 ( 11 )   e13316   2017.6

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    Plasma membrane calcium pump isoform 1 (PMCA1) is encoded by ATPase plasma membrane Ca
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    transporting 1 (ATP2B1), the most likely candidate gene responsible for hypertension. Although PMCA1 is highly expressed in the kidney, little is known about regulation of its renal expression in various pathological conditions in vivo. Our study was designed to elucidate regulation of renal PMCA1 expression in mice. We employed three mouse models for kidney disease. These were the unilateral ureteral obstruction (UUO), the remnant kidney using 5/6 nephrectomy, and chronic angiotensin II administration models. Mice were assessed for systolic blood pressure and renal injury in accordance with the damage induced in the specific model. Kidney PMCA1 mRNA levels were measured in all mice. The UUO model showed renal fibrosis but no changes in blood pressure or renal PMCA1 mRNA expression. Similarly, the 5/6 nephrectomy model exhibited declined renal function without changes in blood pressure or renal PMCA1 mRNA expression. In contrast, chronic angiotensin II administration increased albuminuria and blood pressure as well as significantly increasing renal PMCA1 mRNA and protein expression. These results suggest that renal PMCA1 has a role as one of the molecules involved in angiotensin II-induced hypertension and kidney injury.

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  • Timing-adjusted iron dosing enhances erythropoiesis-stimulating agent-induced erythropoiesis response and iron utilization. Reviewed

    Kawano T, Kuji T, Fujikawa T, Ueda E, Shino M, Yamaguchi S, Ohnishi T, Tamura K, Hirawa N, Toya Y

    Renal Replacement Therapy   3 ( 1 )   2017.3

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  • Relationship between Arterial Stiffness and Blood Pressure Drop During the Sit-to-stand Test in Patients with Diabetes Mellitus Reviewed

    Yusuke Kobayashi, Tetsuya Fujikawa, Hideo Kobayashi, Koichiro Sumida, Shota Suzuki, Minako Kagimoto, Yuki Okuyama, Yosuke Ehara, Mari Katsumata, Megumi Fujita, Akira Fujiwara, Sanae Saka, Keisuke Yatsu, Tatsuo Hashimoto, Tadashi Kuji, Nobuhito Hirawa, Yoshiyuki Toya, Gen Yasuda, Satoshi Umemura

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   24 ( 2 )   147 - 156   2017

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  • Role of renin-angiotensin system inhibitors in retardation of progression of end-stage renal failure: a retrospective study Reviewed

    Tomoyuki Murakami, Tamio Iwamoto, Gen Yasuda, Michiko Taniguchi, Akira Fujiwara, Nobuhito Hirawa, Satoshi Umemura

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   20 ( 4 )   603 - 610   2016.8

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  • SP548EFFECT OF IRON DOSING ON IRON-RELATED PARAMETERS DURING ACTIVATED ERYTHROPOIESIS BY ERITHROPOIESIS Reviewed

    Authors, Tadashi Kuji, Tomoyuki Kawano, Eiko Ueda, Tetsuya Fujikawa, Midori Shino, Satoshi Yamaguchi, Kazuhiko Shibata, Ohnishi Toshimasa, Kouichi Tamura, Nobuhito Hirawa, Yoshiyuki Toya, Satoshi Umemura

    Nephrology Dialysis Transplantation   31   i274   2016.5

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  • Relation between circadian blood pressure rhythm and serum albumin level in non-diabetic patients with proteinuria Reviewed

    Daisaku Ando, Nobuhito Hirawa, Gen Yasuda

    BLOOD PRESSURE   25 ( 1 )   44 - 50   2016.1

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    DOI: 10.3109/08037051.2016.1095916

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  • Genome-wide association study of IgA nephropathy using 23 465 microsatellite markers in a Japanese population Reviewed

    Sanae Saka, Nobuhito Hirawa, Akira Oka, Keisuke Yatsu, Takeshi Hirukawa, Ryohei Yamamoto, Taiji Matsusaka, Enyu Imai, Ichiei Narita, Masayuki Endoh, Iekuni Ichikawa, Satoshi Umemura, Hidetoshi Inoko

    JOURNAL OF HUMAN GENETICS   60 ( 10 )   573 - 580   2015.10

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    DOI: 10.1038/jhg.2015.88

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  • Efficacy of cyclosporine combination therapy for new-onset minimal change nephrotic syndrome in adults Reviewed

    Akira Fujiwara, Nobuhito Hirawa, Yusuke Kobayashi, Keisuke Yatsu, Mari Katsumata, Yohsuke Ehara, Yuki Okuyama, Jun Yutoh, Tomoko Kaneda, Megumi Fujita, Yuichiro Yamamoto, Sanae Saka, Yoshiyuki Toya, Gen Yasuda, Satoshi Umemura

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   19 ( 2 )   240 - 246   2015.4

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    DOI: 10.1007/s10157-014-0975-0

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  • Acceleration of Iron Utilization After Intravenous Iron Administration During Activated Erythropoiesis in Hemodialysis Patients: A Randomized Study Reviewed

    Tadashi Kuji, Yoshiyuki Toya, Tetsuya Fujikawa, Midori Kakimoto-Shino, Masahiro Nishihara, Kazuhiko Shibata, Kouichi Tamura, Nobuhito Hirawa, Hidehisa Satta, Sei-ichi Kawata, Naoaki Kouguchi, Satoshi Umemura

    THERAPEUTIC APHERESIS AND DIALYSIS   19 ( 2 )   131 - 137   2015.4

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  • Effects of doxazosin as the third agent on morning hypertension and position-related blood pressure changes in diabetic patients with chronic kidney disease Reviewed

    Gen Yasuda, Sanae Saka, Daisaku Ando, Nobuhito Hirawa

    CLINICAL AND EXPERIMENTAL HYPERTENSION   37 ( 1 )   75 - 81   2015

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    DOI: 10.3109/10641963.2014.913599

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  • Loss of Amino Acids Into Dialysate During Hemodialysis Using Hydrophilic and Nonhydrophilic Polyester-Polymer Alloy and Polyacrylonitrile Membrane Dialyzers Reviewed

    Atsuko Yokomatsu, Tetsuya Fujikawa, Yoshiyuki Toya, Midori Shino-Kakimoto, Yoko Itoh, Hiroshi Mitsuhashi, Kouichi Tamura, Nobuhito Hirawa, Gen Yasuda, Satoshi Umemura

    THERAPEUTIC APHERESIS AND DIALYSIS   18 ( 4 )   340 - 346   2014.8

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  • Impaired nitric oxide production and increased blood pressure in systemic heterozygous ATP2B1 null mice Reviewed

    Akira Fujiwara, Nobuhito Hirawa, Megumi Fujita, Yusuke Kobayashi, Yuki Okuyama, Keisuke Yatsu, Mari Katsumata, Yuichiro Yamamoto, Naoaki Ichihara, Sanae Saka, Yoshiyuki Toya, Gen Yasuda, Yoshio Goshima, Yasuharu Tabara, Tetsuro Miki, Hirotsugu Ueshima, Yoshihiro Ishikawa, Satoshi Umemura

    JOURNAL OF HYPERTENSION   32 ( 7 )   1415 - 1423   2014.7

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    DOI: 10.1097/HJH.0000000000000206

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  • 慢性炎症性脱髄性多発神経炎合併透析患者に対し二重膜濾過血漿交換を施行した一例

    坂 早苗, 平和 伸仁, 松田 佳奈, 勝又 真理, 金口 翔, 山本 有一郎, 安田 元, 岸田 日帯, 梅村 敏

    日本透析医学会雑誌   47 ( Suppl.1 )   630 - 630   2014.5

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  • Kidney Diseases Enhance Expression of Tetraspanin-8: A Possible Protective Effect against Tubular Injury. Reviewed

    Hirukawa T, Wu Q, Sawada K, Matsusaka T, Saka S, Oka A, Hirawa N, Umemura S, Kakuta T, Endoh M, Inoko H, Ichikawa I, Fukagawa M

    Nephron extra   4 ( 1 )   70 - 81   2014.1

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    &lt;b&gt;&lt;i&gt;Background/Aims:&lt;/i&gt;&lt;/b&gt;&lt;i&gt;TSPAN8&lt;/i&gt; encoding tetraspanin-8 was identified as a candidate gene for immunoglobulin A nephropathy (IgAN) by a genome-wide association study using microsatellites in the Japanese population. Tetraspanin-8 is a cell surface protein that contributes to the migration and invasion of epithelial cells. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We performed immunohistochemistry for tetraspanin-8 on human renal biopsy specimens associated with IgAN, antineutrophil cytoplasmic antibody-associated nephropathy and interstitial nephritis, as well as normal renal tissue. Furthermore, to study the potential function of tetraspanin-8, we performed cell migration and invasion assays using human renal tubule cells transfected with tetraspanin-8. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Tetraspanin-8 was often expressed in vascular smooth muscle cells and occasionally in tubule cells in normal kidney. In the kidneys of all types of nephropathy, tetraspanin-8 staining in the arteries was unaffected, but that in the tubules was enhanced. The degree of tubular staining negatively correlated with the estimated glomerular filtration rate, independently of the type of nephropathy. Tetraspanin-8-expressing tubule cells were found predominantly in distal and collecting tubules, identified by cytokeratin 7 or aquaporin 2 staining. In vitro studies using cultured tubule cells revealed that tetraspanin-8 promoted migration by 2.7-fold without laminin, by 2.8-fold with laminin and invasion into Matrigel by 3.5-fold, suggesting that enhanced tetraspanin-8 may be involved in the repair of tubules. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; The obtained findings indicate that tetraspanin-8 expression is enhanced in injured distal tubules, which may be involved in the repair of tubules by facilitating migration and invasion.

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  • Angiotensin Receptor-Binding Protein ATRAP/Agtrap Inhibits Metabolic Dysfunction With Visceral Obesity Reviewed

    Akinobu Maeda, Kouichi Tamura, Hiromichi Wakui, Toru Dejima, Masato Ohsawa, Kengo Azushima, Tomohiko Kanaoka, Kazushi Uneda, Miyuki Matsuda, Akio Yamashita, Nobuko Miyazaki, Keisuke Yatsu, Nobuhito Hirawa, Yoshiyuki Toya, Satoshi Umemura

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   2 ( 4 )   e000312   2013.8

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  • 線維筋性異形成に伴う右腎動脈狭窄による腎血管性高血圧症の1例

    坂 早苗, 平和 伸仁, 松田 佳奈, 勝又 真理, 金口 翔, 山本 有一郎, 谷津 圭介, 塚原 健吾, 日比 潔, 安田 元, 梅村 敏

    日本腎臓学会誌   55 ( 6 )   1037 - 1037   2013.8

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  • Effect of Renin-Angiotensin System Inhibitor on Residual Glomerular Filtration Rate in Hemodialysis Patients Reviewed

    Yoko Itoh, Tetsuya Fujikawa, Yoshiyuki Toya, Hiroshi Mitsuhashi, Naoyuki Kobayashi, Toshimasa Ohnishi, Kouichi Tamura, Nobuhito Hirawa, Gen Yasuda, Satoshi Umemura

    THERAPEUTIC APHERESIS AND DIALYSIS   17 ( 2 )   243 - 243   2013.4

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    DOI: 10.1111/1744-9987.12032

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  • ATP2B1 and blood pressure: from associations to pathophysiology Reviewed

    Nobuhito Hirawa, Akira Fujiwara, Satoshi Umemura

    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION   22 ( 2 )   177 - 184   2013.3

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    DOI: 10.1097/MNH.0b013e32835da4ca

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  • A Case of Severe Pemphigus Vulgaris Successfully Treated by Rituximab with Long-term Complete Remission

    Matsukura Setsuko, Ikezawa Yuko, Mukaijo Junko, Hirawa Nobuhito, Sawaki Haruna, Muraishi Michiru, Maeda Nobuko, Yamada Hiromichi, Takahashi Kazuo, Ikezawa Zenro, Aihara Michiko, Kambara Takeshi

    The Japanese Journal of Dermatology   123 ( 4 )   415 - 423   2013

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    We present a case of a 49-year-old Japanese woman with recalcitrant pemphigus vulgaris associated with multiple severe infections and very high anti-desmoglein 1 and 3 antibody titers. The lesions covered more than 70% of her body surface area. A combination of repeated steroid pulse therapy, plasmapheresis, and IVIG could not control the disease. However, a single cycle of rituximab therapy led to complete remission for 18 months, during her steroid dose was tapered. No adverse effects have been observed till date. Rituximab is a chimeric murine?human monoclonal antibody that targets the CD20 antigen found on B cells andcauses rapid depletion of this cell population. It has been approved for the treatment of non-Hodgkin B-cell lymphoma and rheumatoid arthritis in the United States. In addition, rituximab has been shown to be effective for the treatment of other autoimmune diseases such as systemic lupus erythematosus and pemphigus. This treatment should be considered for recalcitrant cases with persistent high titers of autoimmune antibodies despite combination therapy with corticosteroids, immunosuppressive agents, plasmapheresis, and IVIG. It can also be considered for cases of recurrence due to tapering of steroids and immunosuppressive agents. However, the adverse effects of immunosuppression by rituximab should be carefully considered for each individual patient.

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  • Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR) Reviewed

    Hitoshi Yokoyama, Hitoshi Sugiyama, Hiroshi Sato, Takashi Taguchi, Michio Nagata, Seiichi Matsuo, Hirofumi Makino, Tsuyoshi Watanabe, Takao Saito, Yutaka Kiyohara, Shinichi Nishi, Hiroyuki Iida, Kunio Morozumi, Atsushi Fukatsu, Tamaki Sasaki, Kazuhiko Tsuruya, Yukimasa Kohda, Makoto Higuchi, Hideyasu Kiyomoto, Shin Goto, Motoshi Hattori, Hiroshi Hataya, Shoji Kagami, Norishige Yoshikawa, Yuichiro Fukasawa, Yoshihiko Ueda, Hiroshi Kitamura, Akira Shimizu, Kazumasa Oka, Naoki Nakagawa, Takafumi Ito, Shunya Uchida, Kengo Furuichi, Izaya Nakaya, Satoshi Umemura, Keiju Hiromura, Mitsuhiro Yoshimura, Nobuhito Hirawa, Takashi Shigematsu, Masafumi Fukagawa, Makoto Hiramatsu, Yoshio Terada, Osamu Uemura, Tetsuya Kawata, Akira Matsunaga, Aki Kuroki, Yasukiyo Mori, Koji Mitsuiki, Haruyoshi Yoshida

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   16 ( 6 )   903 - 920   2012.12

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    DOI: 10.1007/s10157-012-0673-8

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  • Effect of Renin-Angiotensin System Inhibitor on Residual Glomerular Filtration Rate in Hemodialysis Patients Reviewed

    Yoko Itoh, Tetsuya Fujikawa, Yoshiyuki Toya, Hiroshi Mitsuhashi, Naoyuki Kobayashi, Toshimasa Ohnishi, Kouichi Tamura, Nobuhito Hirawa, Gen Yasuda, Satoshi Umemura

    THERAPEUTIC APHERESIS AND DIALYSIS   16 ( 6 )   554 - 559   2012.12

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  • Hunting for genes for hypertension: the Millennium Genome Project for Hypertension. Reviewed

    Tabara Y, Kohara K, Miki T, Millennium Genome, Project for Hypertension(Fujioka A, Hanada H, Hata A, Hirawa N, Hiura Y, Imai Y, Inoko H, Itoh N, Iwai N, Kulski JK, Kamide K, Kato N, Osaka TK, Kawamoto R, Kawano Y, Kimura A, Kita Y, Kohara K, Kokubo Y, Mano H, Mano S, Miki T, Miyata T, Mizuki N, Morisaki T, Nakamura Y, Nakao K, Nakayama T, Nakura J, Ogawa M, Ogihara T, Ohkubo T, Ohno S, Oka A, Okamura T, Saruta T, Sekine A, Shiwa T, Soma M, Sugano S, Tabara Y, Tajima A, Takahashi N, Takashima N, Takeuchi F, Tokunaga K, Tomoike H, Umemura S, Yamane T, Yanai K, Yasunami M, Yatsu K, Yoshida T, Tabara Y

    Hypertens Res.   35 ( 6 )   567-73. - 573   2012.6

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    DOI: 10.1038/hr.2012.41

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  • Mice Lacking Hypertension Candidate Gene ATP2B1 in Vascular Smooth Muscle Cells Show Significant Blood Pressure Elevation Reviewed

    Yusuke Kobayashi, Nobuhito Hirawa, Yasuharu Tabara, Hidenori Muraoka, Megumi Fujita, Nobuko Miyazaki, Akira Fujiwara, Yasuhiro Ichikawa, Yuichiro Yamamoto, Naoaki Ichihara, Sanae Saka, Hiromichi Wakui, Shin-ichiro Yoshida, Keisuke Yatsu, Yoshiyuki Toya, Gen Yasuda, Katsuhiko Kohara, Yoshikuni Kita, Kohtaro Takei, Yoshio Goshima, Yoshihiro Ishikawa, Hirotsugu Ueshima, Tetsuro Miki, Satoshi Umemura

    HYPERTENSION   59 ( 4 )   854 - U213   2012.4

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    DOI: 10.1161/HYPERTENSIONAHA.110.165068

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  • Effects of Carvedilol as Third-Line Add-On Therapy on Blood Pressure and Glucose Metabolism in Type 2 Diabetic Patients with Chronic Renal Disease Stage 3 and Above Reviewed

    Gen Yasuda, Keisuke Yatsu, Yuichiro Yamamoto, Nobuhito Hirawa

    KIDNEY & BLOOD PRESSURE RESEARCH   36 ( 1 )   131 - 138   2012

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  • Long-Term Efficacy and Safety of the Small-Sized beta 2-Microglobulin Adsorption Column for Dialysis-Related Amyloidosis Reviewed

    Yuichiro Yamamoto, Nobuhito Hirawa, Satoshi Yamaguchi, Nariaki Ogawa, Hideyuki Takeda, Ken Shibuya, Kimiko Kawahara, Hirofumi Kojima, Yasushi Dobashi, Megumi Fujita, Kengo Azusima, Nobuko Miyazaki, Mayumi Kobayashi, Chinatsu Kobayashi, Akira Fujiwara, Jun Yuto, Sanae Saka, Keisuke Yatsu, Yoshiyuki Toya, Gen Yasuda, Toshimasa Ohnishi, Satoshi Umemura

    THERAPEUTIC APHERESIS AND DIALYSIS   15 ( 5 )   466 - 474   2011.10

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    DOI: 10.1111/j.1744-9987.2011.00937.x

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  • 血液透析導入を契機に好酸球増多を呈し、診断・治療に難渋した特発性好酸球増多症の一例

    新倉 利啓, 藤田 恵美, 小豆島 健護, 湯藤 潤, 山本 有一郎, 坂 早苗, 谷津 圭介, 平和 伸仁, 安田 元, 梅村 敏

    日本腎臓学会誌   53 ( 6 )   962 - 962   2011.8

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  • 急性腎不全を呈し、血栓性微小血管障害症(TMA)の診断に至ったシェーグレン症候群の一例

    奥山 由紀, 藤田 恵美, 小豆島 健護, 湯藤 潤, 山本 有一郎, 坂 早苗, 谷津 圭介, 平和 伸仁, 安田 元, 梅村 敏

    日本腎臓学会誌   53 ( 6 )   950 - 950   2011.8

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  • ネフローゼ症候群を伴う感染性心内膜炎に抗菌薬による薬剤性間質性腎炎が合併したため治療に難渋した一例

    藤田 恵美, 平和 伸仁, 谷津 圭介, 勝又 真理, 小豆島 健護, 湯藤 潤, 山本 有一郎, 坂 早苗, 安田 元, 梅村 敏

    日本腎臓学会誌   53 ( 6 )   944 - 944   2011.8

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  • 悪性高血圧症・腎不全の原因に、覚せい剤などの違法薬物が疑われ、初期治療に難渋するも血液透析を離脱できた一例

    藤田 恵美, 谷津 圭介, 岡田 瑠奈, 小豆島 健護, 湯藤 潤, 山本 有一郎, 坂 早苗, 戸谷 義幸, 安田 元, 平和 伸仁, 梅村 敏

    日本透析医学会雑誌   44 ( Suppl.1 )   566 - 566   2011.5

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  • 急性腹膜炎による敗血症で心肺停止になるも救命できた腹膜透析患者の一例

    湯藤 潤, 谷津 圭介, 藤田 恵美, 小豆島 健護, 山本 有一郎, 坂 早苗, 戸谷 義幸, 安田 元, 平和 伸仁, 梅村 敏

    日本透析医学会雑誌   44 ( Suppl.1 )   628 - 628   2011.5

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  • 末期腎不全患者の心不全症状に対してトルバプタンの併用を行い血液透析離脱が可能であった一例

    勝又 真理, 谷津 圭介, 藤田 恵美, 小豆島 健護, 湯藤 潤, 山本 有一郎, 坂 早苗, 戸谷 義幸, 安田 元, 平和 伸仁, 梅村 敏

    日本透析医学会雑誌   44 ( Suppl.1 )   633 - 633   2011.5

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  • Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advanced Glycation End Products in Hemodialysis Patients Reviewed

    Takatoshi Kakuta, Reika Tanaka, Toru Hyodo, Hajime Suzuki, Genta Kanai, Mikako Nagaoka, Hiroo Takahashi, Nobuhito Hirawa, Yoichi Oogushi, Toshio Miyata, Hiroyuki Kobayashi, Masafumi Fukagawa, Akira Saito

    AMERICAN JOURNAL OF KIDNEY DISEASES   57 ( 3 )   422 - 431   2011.3

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  • 【身体所見からのCKD患者の栄養評価の重要性】浮腫・胸水・腹水の評価

    小豆島 健護, 平和 伸仁

    臨床透析   26 ( 13 )   1673 - 1678   2010.12

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  • Common Variants in the ATP2B1 Gene Are Associated With Susceptibility to Hypertension The Japanese Millennium Genome Project Reviewed

    Yasuharu Tabara, Katsuhiko Kohara, Yoshikuni Kita, Nobuhito Hirawa, Tomohiro Katsuya, Takayoshi Ohkubo, Yumiko Hiura, Atsushi Tajima, Takayuki Morisaki, Toshiyuki Miyata, Tomohiro Nakayama, Naoyuki Takashima, Jun Nakura, Ryuichi Kawamoto, Norio Takahashi, Akira Hata, Masayoshi Soma, Yutaka Imai, Yoshihiro Kokubo, Tomonori Okamura, Hitonobu Tomoike, Naoharu Iwai, Toshio Ogihara, Itsuro Inoue, Katsushi Tokunaga, Toby Johnson, Mark Caulfield, Patricia Munroe, Satoshi Umemura, Hirotsugu Ueshima, Tetsuro Miki

    HYPERTENSION   56 ( 5 )   973 - U533   2010.11

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  • 慢性腎臓病合併高血圧症に対するオルメサルタンの降圧作用および腎保護作用に関する検討

    小豆島 健護, 平和 伸仁, 安田 元, 内田 健, 垣本 みどり, 澁谷 研, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   33回   368 - 368   2010.10

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  • Silent Brain Infarction and Rapid Decline of Kidney Function in Patients With CKD: A Prospective Cohort Study Reviewed

    Mayumi Kobayashi, Nobuhito Hirawa, Satoshi Morita, Keisuke Yatsu, Yusuke Kobayashi, Yuichiro Yamamoto, Sanae Saka, Yoshiyuki Toya, Gen Yasuda, Satoshi Umemura

    AMERICAN JOURNAL OF KIDNEY DISEASES   56 ( 3 )   468 - 476   2010.9

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    DOI: 10.1053/j.ajkd.2010.03.018

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  • バルサルタンにて降圧不十分な本態性高血圧症に対するオルメサルタンの効果

    小豆島 健護, 平和 伸仁, 安田 元, 内田 健, 垣本 みどり, 澁谷 研

    日本腎臓学会誌   52 ( 6 )   725 - 725   2010.8

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  • 36年前に診断されるも心肥大、腎機能障害が発症してから酵素補充療法を導入されたFabry病の一例

    藤田 恵美, 平和 伸仁, 諸宇 旭純, 藤原 亮, 宮崎 喜子, 小豆島 健護, 湯藤 潤, 坂 早苗, 山本 有一郎, 谷津 圭介, 安田 元, 梅村 敏

    日本腎臓学会誌   52 ( 6 )   713 - 713   2010.8

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  • Cardiac-Specific Activation of Angiotensin II Type 1 Receptor-Associated Protein Completely Suppresses Cardiac Hypertrophy in Chronic Angiotensin II-Infused Mice Reviewed

    Hiromichi Wakui, Kouichi Tamura, Yutaka Tanaka, Miyuki Matsuda, Yunzhe Bai, Toru Dejima, Shin-ichiro Masuda, Atsu-ichiro Shigenaga, Akinobu Maeda, Masaki Mogi, Naoaki Ichihara, Yusuke Kobayashi, Nobuhito Hirawa, Tomoaki Ishigami, Yoshiyuki Toya, Machiko Yabana, Masatsugu Horiuchi, Susumu Minamisawa, Satoshi Umemura

    HYPERTENSION   55 ( 5 )   1157 - U138   2010.5

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  • Sustained Inhibition of Oxidized Low-Density Lipoprotein Is Involved in the Long-Term Therapeutic Effects of Apheresis in Dialysis Patients Reviewed

    Yuko Tsurumi-Ikeya, Kouichi Tamura, Koichi Azuma, Hiroshi Mitsuhashi, Hiromichi Wakui, Ichiro Nakazawa, Teruyasu Sugano, Yasuyuki Mochida, Toshiaki Ebina, Nobuhito Hirawa, Yoshiyuki Toya, Kazuaki Uchino, Satoshi Umemura

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   30 ( 5 )   1058 - U351   2010.5

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  • Effects of atorvastatin versus probucol on low-density lipoprotein subtype distribution and renal function in hyperlipidemic patients with nondiabetic nephropathy Reviewed

    Gen Yasuda, Daisaku Ando, Nobuhito Hirawa, Satoshi Umemura

    RENAL FAILURE   32 ( 6 )   680 - 686   2010

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  • Association of SLC6A9 Gene Variants with Human Essential Hypertension Reviewed

    Takahiro Ueno, Yasuharu Tabara, Noboru Fukuda, Kazunobu Tahira, Taro Matsumoto, Kotoko Kosuge, Akira Haketa, Koichi Matsumoto, Yuichi Sato, Tomohiro Nakayama, Tomohiro Katsuya, Toshio Ogihara, Yoshio Makita, Akira Hata, Michiko Yamada, Norio Takahashi, Nobuhito Hirawa, Satoshi Umemura, Tetsuro Miki, Masayoshi Soma

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   16 ( 3 )   201 - 206   2009.6

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  • Loss of nocturnal decline of blood pressure in non-diabetic patients with nephrotic syndrome in the early and middle stages of chronic kidney disease Reviewed

    Daisaku Andoh, Mayumi Kobayashi, Gen Yasuda, Nobuhito Hirawa, Sanae Saka, Keisuke Yatsu, Yuichiro Yamamoto, Satoshi Umemura

    HYPERTENSION RESEARCH   32 ( 5 )   364 - 368   2009.5

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  • Urinary excretions of lipocalin-type prostaglandin D synthase predict renal injury in type-2 diabetes: a cross-sectional and prospective multicentre study

    Yoshio Uehara, Hirofumi Makino, Kousuke Seiki, Yoshihiro Urade

    NEPHROLOGY DIALYSIS TRANSPLANTATION   24 ( 2 )   475 - 482   2009.2

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  • Relationship between silent brain infarction and chronic kidney disease Reviewed

    Mayumi Kobayashi, Nobuhito Hirawa, Keisuke Yatsu, Yusuke Kobayashi, Yuichiro Yamamoto, Sanae Saka, Daisaku Andoh, Yoshiyuki Toya, Gen Yasuda, Satoshi Umemura

    NEPHROLOGY DIALYSIS TRANSPLANTATION   24 ( 1 )   201 - 207   2009.1

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  • Urinary oxidative stress markers closely reflect the efficacy of candesartan treatment for diabetic nephropathy. Reviewed

    Yoshida S, Hashimoto T, Kihara M, Imai N, Yasuzaki H, Nomura K, Kiuchi Y, Tamura K, Ishigami T, Hirawa N, Toya Y, Kitamura H, Umemura S

    Nephron. Experimental nephrology   111   e20 - 30   2009

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  • Localization and Extent of Peritoneal Calcification in Three Uremic Patients on Continuous Ambulatory Peritoneal Dialysis Reviewed

    Kyoko Dejima, Hiroshi Mitsuhashi, Gen Yasuda, Nobuhito Hirawa, Yumiko Ikeda, Satoshi Urnemura

    THERAPEUTIC APHERESIS AND DIALYSIS   12 ( 5 )   413 - 416   2008.10

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    DOI: 10.1111/j.1744-9987.2008.06620.x

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  • アペリン-APJ系は新たな動脈硬化症増悪因子である

    橋本 達夫, 吉田 伸一郎, 木原 実, 今井 のぞみ, 下山田 博明, 石田 純治, 木内 吉寛, 安崎 弘晃, 一原 直昭, 宮本 研, 戸谷 義幸, 平和 伸仁, 田村 功一, 矢澤 卓也, 北村 均, 深水 昭吉, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   31回   179 - 179   2008.10

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  • Association between fatty acid binding protein 3 gene variants and essential hypertension in humans Reviewed

    Takahiro Ueno, Masayoshi Soma, Yasuharu Tabara, Katsushi Tokunaga, Kzunobu Tahira, Noboru Fukuda, Koichi Matsumoto, Tomohiro Nakayama, Tomohiro Katsuya, Toshio Ogihara, Yoshio Makita, Akira Hata, Michiko Yamada, Norio Takahashi, Nobuhito Hirawa, Satoshi Umemura, Tetsuro Miki

    AMERICAN JOURNAL OF HYPERTENSION   21 ( 6 )   691 - 695   2008.6

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    BACKGROUND We have earlier identified a quantitative trait locus (QTL) on rat chromosome 5 that appears to be primarily under the control of the sympathetic nervous system. Because sympathetic overactivity is related to both hypertension and insulin resistance, FABP3 is a candidate gene for the link between this QTL and blood pressure regulation. In this study, therefore, we explored the role of FABP3 genetic variations in essential hypertension (EH) in humans.
    METHODS We evaluated two single-nucleotide polymorphisms (SNPs) (rs2279885 and rs2271072) in 758 patients with EH and 726 controls. Polymorphism-related genotypes were determined using TaqMan assays, while haplotypes were estimated from the genotype data.
    RESULTS The frequencies of occurrence of the G allele of rs2279885 and the C allele of rs2271072 were significantly higher in subjects with EH than in normotensive (NT) subjects (P = 0.0339, P = 0.0209, respectively). However, the genotype distributions did not exhibit any significant differences.
    CONCLUSION We found an association between FABP3 gene polymorphisms and EH in a Japanese population, thereby suggesting that FABP3 is a susceptibility locus for EH.

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  • Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis Reviewed

    T. Hashimoto, M. Kihara, N. Imai, S. Yoshida, H. Shimoyarnada, H. Yasuzaki, J. Ishida, Y. Toya, Y. Kiuchi, N. Hirawa, K. Tamura, T. Yazawa, H. Kitamura, A. Fukamizu, S. Umemura

    JOURNAL OF HYPERTENSION   26 ( Suppl. 1 )   S158 - S158   2008.6

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  • Association between fatty acid binding protein 3 gene variants and essential hypertension in humans Reviewed

    Takahiro Ueno, Masayoshi Soma, Yasuharu Tabara, Katsushi Tokunaga, Kzunobu Tahira, Noboru Fukuda, Koichi Matsumoto, Tomohiro Nakayama, Tomohiro Katsuya, Toshio Ogihara, Yoshio Makita, Akira Hata, Michiko Yamada, Norio Takahashi, Nobuhito Hirawa, Satoshi Umemura, Tetsuro Miki

    AMERICAN JOURNAL OF HYPERTENSION   21 ( 6 )   691 - 695   2008.6

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    BACKGROUND We have earlier identified a quantitative trait locus (QTL) on rat chromosome 5 that appears to be primarily under the control of the sympathetic nervous system. Because sympathetic overactivity is related to both hypertension and insulin resistance, FABP3 is a candidate gene for the link between this QTL and blood pressure regulation. In this study, therefore, we explored the role of FABP3 genetic variations in essential hypertension (EH) in humans.
    METHODS We evaluated two single-nucleotide polymorphisms (SNPs) (rs2279885 and rs2271072) in 758 patients with EH and 726 controls. Polymorphism-related genotypes were determined using TaqMan assays, while haplotypes were estimated from the genotype data.
    RESULTS The frequencies of occurrence of the G allele of rs2279885 and the C allele of rs2271072 were significantly higher in subjects with EH than in normotensive (NT) subjects (P = 0.0339, P = 0.0209, respectively). However, the genotype distributions did not exhibit any significant differences.
    CONCLUSION We found an association between FABP3 gene polymorphisms and EH in a Japanese population, thereby suggesting that FABP3 is a susceptibility locus for EH.

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  • Plasmapheresis for the Treatment of Two Patients with Epidermolysis Bullosa Acquisita

    Ikezawa Yuko, Takahashi Kazuo, Hasegawa Miki, Chiba Yoshiyuki, Wada Hidefumi, Tamura Kouichi, Hirawa Shinji, Toya Yoshiyuki, Ikezawa Zenro

    Japanese journal of apheresis   27 ( 2 )   133 - 138   2008.5

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    Epidermolysis bullosa acquisita (EBA) is a comparatively rare autoimmune disease producing blisters at the subepidermal area similarly to bullous pemphigoid. Corticosteroid therapy is the first treatment of choice. However, the disease is refractory to such treatment in more than half of patients. Here, we treated 2 patients initially with systemic corticosteroids and then in combination with double filtration plasmapheresis (DFPP), which proved effective in both cases. The efficacy of DFPP has also been reported in 4 other Japanese cases. Therefore, we believe that it is important to immed...

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  • Association of TNFRSF4 gene polymorphisms with essential hypertension Reviewed

    Yoichi Mashimo, Yoichi Suzuki, Kazuko Hatori, Yasuharu Tabara, Tetsuro Miki, Katsushi Tokunaga, Tomohiro Katsuya, Toshio Ogihara, Michiko Yamada, Norio Takahashi, Yoshio Makita, Tomohiro Nakayama, Masayoshi Soma, Nobuhito Hirawa, Satoshi Umemura, Takayoshi Ohkubo, Yutaka Imai, Akira Hata

    JOURNAL OF HYPERTENSION   26 ( 5 )   902 - 913   2008.5

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    DOI: 10.1097/HJH.0b013e3282f6a65e

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  • Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: The millennium genome project for hypertension Reviewed

    Katsuhiko Kohara, Yasuharu Tabara, Jun Nakura, Yutaka Imai, Takayoshi Ohkubo, Akira Hata, Masayoshi Soma, Tomohiro Nakayama, Satoshi Umemura, Nobuhito Hirawa, Hirotsugu Ueshima, Yoshikuni Kita, Toshio Ogihara, Tornohiro Katsuya, Norio Takahashi, Katsushi Tokunaga, Tetsuro Miki

    HYPERTENSION RESEARCH   31 ( 2 )   203 - 212   2008.2

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  • Sevelamer hydrochloride improves hyperphosphatemia in hemodialysis patients with low bone turnover rate and low intact parathyroid hormone levels Reviewed

    Toshiharu Kokuho, Yoshiyuki Toya, Yoshiaki Kawaguchi, Koichi Tamura, Kousaku Iwatsubo, Yasushi Dobashi, Akiko Nakazawa, Hideyuki Takeda, Mizuka Iwatsubo, Nobuhito Hirawa, Gen Yasuda, Toshimasa Ohnishi, Satoshi Umemura

    THERAPEUTIC APHERESIS AND DIALYSIS   11 ( 6 )   442 - 448   2007.12

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    DOI: 10.1111/j.1744-9987.2007.00524.x

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  • Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis Reviewed

    Tatsuo Hashimoto, Minoru Kihara, Nozomi Imai, Shin-Ichiro Yoshida, Hiroaki Shimoyamada, Hiroaki Yasuzaki, Junji Ishida, Yoshiyuki Toya, Yoshilhiro Kiuchi, Nobuhito Hirawa, Kouichi Tamura, Takuya Yazawa, Hitoshi Kitamura, Akiyoshi Fukamizu, Satoshi Umemura

    AMERICAN JOURNAL OF PATHOLOGY   171 ( 5 )   1705 - 1712   2007.11

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    DOI: 10.2353/ajpath.2007.070471

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  • Fatty Acid Binding Protein 3遺伝子の本態性高血圧症との関連(ミレニアムプロジェクト)

    上野 高浩, 相馬 正義, 田原 康玄, 徳永 勝士, 田平 和宣, 中山 智祥, 松本 太郎, 福田 昇, 松本 紘一, 勝谷 友宏, 荻原 俊男, 蒔田 芳男, 羽田 明, 山田 美智子, 高橋 規郎, 平和 伸仁, 梅村 敏, 三木 哲郎

    日本高血圧学会総会プログラム・抄録集   30回   235 - 235   2007.10

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  • NEDD4L protein truncating variant (v13[G/A]: rs4149601) is associated with essential hypertension in a sample of the Japanese population Reviewed

    Tomoaki Ishigami, Masanari Umemura, Naomi Araki, Nobuhito Hirawa, Koichi Tamura, Kazuaki Uchino, Satoshi Umemura, Andreas Rohrwasser, Jean-Marc Lalouel

    GERIATRICS & GERONTOLOGY INTERNATIONAL   7 ( 2 )   114 - 117   2007.6

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    DOI: 10.1111/j.1447-0594.2007.00382.x

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  • 糖尿病性慢性腎不全患者での血圧短期変動性の意義についての検討

    田村 功一, 岡野 泰子, 小澤 素子, 酒井 政司, 平和 伸仁, 戸谷 義幸, 矢花 真知子, 常田 康夫, 大西 俊正, 梅村 敏

    日本内分泌学会雑誌   83 ( 1 )   161 - 161   2007.4

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  • 脂肪肝と血圧、G蛋白αサブユニット遺伝子多型の関係

    平和 伸仁, 小川 桃子, 志和 忠志, 田原 康玄, 徳永 麻裕美, 山本 有一郎, 坂 早苗, 安藤 大作, 谷津 圭介, 遠藤 晃彦, 戸谷 義幸, 安田 元, 三木 哲郎, 大西 俊正, 梅村 敏

    日本腎臓学会誌   49 ( 3 )   250 - 250   2007.4

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  • High-resolution mapping for essential hypertension using microsatellite markers Reviewed

    Keisuke Yatsu, Nobuhisa Mizuki, Nobuhito Hirawa, Akira Oka, Norihiko Itoh, Takahiro Yamane, Momoko Ogawa, Tadashi Shiwa, Yasuharu Tabara, Shigeaki Ohno, Masayoshi Soma, Akira Hata, Kazuwa Nakao, Hirotsugu Ueshima, Toshio Ogihara, Hitonobu Tomoike, Tetsuro Miki, Akinori Kimura, Shuhei Mano, Jerzy K. Kulski, Satoshi Umemura, Hidetoshi Inoko

    HYPERTENSION   49 ( 3 )   446 - 452   2007.3

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    DOI: 10.1161/01.HYP.0000257256.77680.02

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  • Follicle stimulating hormone受容体(FSHR)遺伝子と本態性高血圧症(EH)との関連解析

    中山 智祥, 三木 哲郎, 勝谷 友宏, 荻原 俊男, 山田 美智子, 平和 伸仁, 梅村 敏, 相馬 正義, 田原 康玄, 羽田 明

    日本内科学会雑誌   96 ( Suppl. )   120 - 120   2007.2

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  • A possible relationship of nocturnal blood pressure variability with coronary artery disease in diabetic nephropathy Reviewed

    Kouichi Tamura, Yuko Tsurumi, Masashi Sakai, Yutaka Tanaka, Yasuko Okano, Junji Yamauchi, Tomoaki Ishigami, Minoru Kihara, Nobuhito Hirawa, Yoshiyuki Toya, Machiko Yabana, Yasuo Tokita, Toshimasa Ohnishi, Satoshi Umemura

    CLINICAL AND EXPERIMENTAL HYPERTENSION   29 ( 1 )   31 - 42   2007.1

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    DOI: 10.1080/10641960601096760

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  • Genome-wide association mapping for essential hypertension with high-density microsatellite markers Reviewed

    Keisuke Yatsu, Nobuhito Hirawa, Momoko Ogawa, Masayoshi Soma, Akira Hata, Kazuwa Nakao, Hirotsugu Ueshima, Toshio Ogihara, Hitonobu Tomoike, Akinori Kimura, Yasuharu Tabara, Tetsuro Miki, Akira Oka, Hidetoshi Inoko, Satoshi Umemura

    JOURNAL OF HYPERTENSION   24   55 - 56   2006.12

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  • Mutation of the follicle-stimulating hormone receptor gene 5 '-untranslated region associated with female hypertension Reviewed

    Tomohiro Nakayama, Nobuhiro Kuroi, Morihiko Sano, Yasuharu Tabara, Tomohiro Katsuya, Toshio Ogihara, Yoshio Makita, Akira Hata, Michiko Yamada, Norio Takahashi, Nobuhito Hirawa, Satoshi Umemura, Tetsuro Miki, Masayoshi Soma

    HYPERTENSION   48 ( 3 )   512 - 518   2006.9

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    DOI: 10.1161/01.HYP.0000233877.84343.d7

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  • Urinary excretions of lipocalin-type prostaglandin D2 synthase predict the development of proteinuria and renal injury in OLETF rats Reviewed

    M Ogawa, N Hirawa, T Tsuchida, N Eguchi, Y Kawabata, A Numabe, H Negoro, R Hakamada-Taguchi, K Seiki, S Umemura, Y Urade, Y Uehara

    NEPHROLOGY DIALYSIS TRANSPLANTATION   21 ( 4 )   924 - 934   2006.4

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  • 腎不全患者の癌発症にかかわる要因の検討

    山本 有一郎, 平和 伸仁, 安田 元, 安藤 大作, 増田 真一朗, 篠田 早苗, 小川 桃子, 戸谷 善幸, 梅村 敏, 遠藤 晃彦, 田村 功一

    日本腎臓学会誌   48 ( 3 )   278 - 278   2006.4

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  • Humpを認めた半月体形成性腎炎の一例

    安藤 大作, 増田 真一朗, 遠藤 晃彦, 篠田 早苗, 平和 伸仁, 安田 元, 梅村 敏, 長濱 清隆

    腎炎症例研究   22   1 - 18   2006.2

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    75歳女.微熱が出現し,内服処方を受けたが改善なく,熱は38℃以上となり,食欲不振も認めたため,急性腎不全の疑いで入院した.Levine III/IVの収縮期雑音を聴取し,呼吸音正常肺胞呼吸音,ラ音なし,腹部平坦軟,圧痛なし,腫瘤触知せず,浮腫,皮疹・紫斑はなかった.組織所見はIgA腎症の予後不良群と診断されたが,臨床経過は血管炎症候群を特に顕微鏡的多発血管炎(MPA)が疑がわれた.症例はIgA腎症にMPAを合併し,ステロイド加療により良好な経過をたどった1例と考えられた.又,電子顕微鏡上,瘤様の高電子密度沈着物を認め,瘤を認めた半月体形成性糸球体腎炎と診断した

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  • Interacting molecule of AT1 receptor, ATRAP, is colocalized with AT1 receptor in the mouse renal tubules Reviewed

    Y Tsurumi, K Tamura, Y Tanaka, Y Koide, M Sakai, M Yabana, Y Noda, T Hashimoto, M Kihara, N Hirawa, Y Toya, Y Kiuchi, M Iwai, M Horiuchi, S Umemura

    KIDNEY INTERNATIONAL   69 ( 3 )   488 - 494   2006.2

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  • Effects of low density lipoprotein apheresis on clinical markers of peripheral arterial disease in the patients undergoing hemodialysis

    Yuko Tsurumi, Kouichi Tamura, Masashi Sakai, Kouichi Azuma, Motoko Ozawa, Kousaku Iwatsubo, Ichiro Nakazawa, Machiko Yabana, Nobuhito Hirawa, Minoru Kihara, Yoshiyuki Toya, Satoshi Umemura

    Therapeutic Research   27 ( 9 )   1745 - 1750   2006

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  • The effects of leptin receptor gene polymorphism on visceral fat accumulation and blood pressure Reviewed

    M. Ogawa, N. Hirawa, T. Shiwa, T. Endoh, K. Yatsu, K. Tamura, T. Ishigami, M. Kihara, Y. Toya, G. Yasuda, Y. Tabara, T. Miki, K. Tokunaga, S. Umemura

    Yokohama Medical Journal   57 ( 1-2 )   35 - 42   2006

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  • Follicle stimulating hormone(FSH)受容体遺伝子5'非翻訳領域の一塩基多型は転写活性に影響し本態性高血圧症と関連する(ミレニアムゲノムプロジェクト)

    中山 智祥, 黒井 信宏, 佐野 守彦, 田原 康玄, 勝谷 友宏, 荻原 俊男, 蒔田 芳男, 羽田 明, 山田 美智子, 高橋 規郎, 平和 伸仁, 梅村 敏, 三木 哲郎, 相馬 正義

    日本高血圧学会総会プログラム・抄録集   28回   71 - 71   2005.9

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  • 高血圧候補遺伝子と脂肪蓄積および血圧の関連性

    小川 桃子, 平和 伸仁, 遠藤 晃彦, 谷津 圭介, 田村 功一, 木原 実, 戸谷 義幸, 安田 元, 田原 康玄, 三木 哲郎, 徳永 勝士, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   28回   198 - 198   2005.9

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  • Effects of losartan and amlodipine on urinary albumin excretion and ambulatory blood pressure in hypertensive type 2 diabetic patients with overt nephropathy Reviewed

    G Yasuda, D Ando, N Hirawa, S Umemura, O Tochikubo

    DIABETES CARE   28 ( 8 )   1862 - 1868   2005.8

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  • Lobular membranoproliferative glomerulonephritis with organized microtubular monoclonal immunoglobulin deposits associated with B cell small lymphocytic lymphoma Reviewed

    K Matsushita, K Nagahama, Y Inayama, K Fujimaki, K Tamura, N Hirawa, M Kihara, Y Toya, M Yabana, K Joh, S Umemura

    NEPHROLOGY DIALYSIS TRANSPLANTATION   20 ( 6 )   1273 - 1274   2005.6

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  • [The gene, synthesis, function of kallikrein]. Reviewed

    Hirawa N, Umemura S

    Nihon rinsho. Japanese journal of clinical medicine   63 Suppl 3   363 - 368   2005.3

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  • Analysis of factors that affect short-term blood pressure variability in patients with chronic renal failure Reviewed

    M Sakai, K Tamura, Y Tanaka, Y Tsurumi, Y Okano, Y Koide, T Endoh, K Matsushita, M Kihara, N Hirawa, Y Toya, Y Tokita, T Ohnishi, S Umemura

    CLINICAL AND EXPERIMENTAL HYPERTENSION   27 ( 2-3 )   139 - 147   2005.2

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  • Implication of base heart rate in autonomic nervous function, blood pressure and health-related QOL Reviewed

    Y Okano, N Hirawa, K Matsushita, K Tamura, M Kihara, Y Toya, O Tochikubo, S Umemura

    CLINICAL AND EXPERIMENTAL HYPERTENSION   27 ( 2-3 )   169 - 178   2005.2

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  • Heparin recovers AT1 receptor and its intracellular signal transduction in cultured vascular smooth muscle cells Reviewed

    T Hashimoto, M Kihara, K Sato, N Imai, Y Tanaka, M Sakai, K Tamura, N Hirawa, Y Toya, H Kitamura, S Umemura

    FEBS LETTERS   579 ( 1 )   281 - 284   2005.1

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  • Expression of cyclooxygenase-2 in the juxtaglomerular apparatus of angiotensinogen gene-knockout mice Reviewed

    T Hashimoto, M Kihara, K Sato-Yokoyama, K Matsushita, Y Koide, Y Inokuchi, T Sugaya, K Tanimoto, K Tamura, N Hirawa, Y Toya, A Fukamizu

    HYPERTENSION   44 ( 4 )   526 - 526   2004.10

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  • Alterations in renal endothelial nitric oxide synthase expression by salt diet in angiotensin type-1a receptor gene knockout mice Reviewed

    K Sato, M Kihara, T Hashimoto, K Matsushita, Y Koide, K Tamura, N Hirawa, Y Toya, A Fukamizu, S Umemura

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   15 ( 7 )   1756 - 1763   2004.7

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    DOI: 10.1097/01.ASN.0000130922.75125.B8

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  • [Prostaglandin/bradykinin]. Reviewed

    Hirawa N, Umemura S

    Nihon rinsho. Japanese journal of clinical medicine   62 Suppl 6   183 - 188   2004.6

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  • OLETFラットに対するtroglitazone治療の影響 尿中L-PGDS排泄量の意義

    平和 伸仁, 上原 誉志夫, 小川 桃子, 酒井 政司, 佐藤 恵子, 鶴見 裕子, 土田 貴正, 松下 啓, 根来 秀行, 江口 直美, 永田 奈々恵, 安田 元, 田村 功一, 木原 実, 戸谷 義幸, 佐藤 信行, 裏出 良博, 梅村 敏

    日本腎臓学会誌   46 ( 3 )   284 - 284   2004.4

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  • Relationships between diurnal blood pressure variation, physical activity, and health-related QOL Reviewed

    Y Okano, N Hirawa, O Tochikubo, S Mizushima, S Fukuhara, M Kihara, Y Toya, S Umemura

    CLINICAL AND EXPERIMENTAL HYPERTENSION   26 ( 2 )   145 - 155   2004.2

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  • Effects of benidipine on daytime blood pressure changes in patients with essential hypertension

    Gen Yasuda, Nariaki Ogawa, Gaku Shimura, Daisaku Ando, Nobuhito Hirawa, Satoshi Umemura, Osamu Tochikubo

    Therapeutic Research   25 ( 8 )   1723 - 1729   2004

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  • Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats Reviewed

    Y Koide, K Tamura, A Suzuki, K Kitamura, K Yokoyama, T Hashimoto, N Hirawa, M Kihara, S Ohno, S Umemura

    HYPERTENSION RESEARCH   26 ( 5 )   421 - 426   2003.5

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    Several protein kinase C (PKC) isoforms may play important roles in cellular signaling pathways. Recent reports have suggested that PKC plays critical isoform-specific roles in the development of cardiac hypertrophy and heart failure. The purpose of the present study was to examine the expression profiles of PKC isoforms in models of cardiac hypertrophy and heart failure. We examined the cardiac expression of individual PKC isoforms at the cardiac hypertrophy stage and the heart failure stage in Dahl salt-sensitive rats by Western blot analysis. The levels of all PKC isoforms increased at the cardiac hypertrophy stage and the heart failure stage, but the pattern of increase differed among PKC isoforms at the heart failure stage. The expressions of PKCalpha, beta, and delta increased at the cardiac hypertrophy stage and remained elevated at the heart failure stage. On the other hand, the expression of PKCepsilon and atypical PKCs (aPKCs) increased at the cardiac hypertrophy stage, but this increase tended to decline at the congestive heart failure stage. These results suggest that there are two groups of PKC isoforms. Several reports have shown that PKCalpha, beta, and delta are involved in the development of cardiac hypertrophy and heart failure, and that PKCepsilon plays a role in the physiological hypertrophic responses and cardioprotective actions. These facts suggest that all PKC isoforms (PKCalpha, beta, delta, epsilon, and aPKCs) expressed in the heart may have similar functions at the cardiac hypertrophy stage, but that two groups of PKC isoforms (PKCalpha, beta, delta, and PKCepsilon, aPKCs) have different functions at the congestive heart failure stage.

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  • Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats Reviewed

    Y Koide, K Tamura, A Suzuki, K Kitamura, K Yokoyama, T Hashimoto, N Hirawa, M Kihara, S Ohno, S Umemura

    HYPERTENSION RESEARCH   26 ( 5 )   421 - 426   2003.5

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    Several protein kinase C (PKC) isoforms may play important roles in cellular signaling pathways. Recent reports have suggested that PKC plays critical isoform-specific roles in the development of cardiac hypertrophy and heart failure. The purpose of the present study was to examine the expression profiles of PKC isoforms in models of cardiac hypertrophy and heart failure. We examined the cardiac expression of individual PKC isoforms at the cardiac hypertrophy stage and the heart failure stage in Dahl salt-sensitive rats by Western blot analysis. The levels of all PKC isoforms increased at the cardiac hypertrophy stage and the heart failure stage, but the pattern of increase differed among PKC isoforms at the heart failure stage. The expressions of PKCalpha, beta, and delta increased at the cardiac hypertrophy stage and remained elevated at the heart failure stage. On the other hand, the expression of PKCepsilon and atypical PKCs (aPKCs) increased at the cardiac hypertrophy stage, but this increase tended to decline at the congestive heart failure stage. These results suggest that there are two groups of PKC isoforms. Several reports have shown that PKCalpha, beta, and delta are involved in the development of cardiac hypertrophy and heart failure, and that PKCepsilon plays a role in the physiological hypertrophic responses and cardioprotective actions. These facts suggest that all PKC isoforms (PKCalpha, beta, delta, epsilon, and aPKCs) expressed in the heart may have similar functions at the cardiac hypertrophy stage, but that two groups of PKC isoforms (PKCalpha, beta, delta, and PKCepsilon, aPKCs) have different functions at the congestive heart failure stage.

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  • Lipoxygenase products regulate nitric oxide and inducible nitric oxide synthase production in interieukin-1 beta stimulated vascular smooth muscle cells Reviewed

    T Hashimoto, M Kihara, K Yokoyama, T Fujita, S Kobayashi, K Matsushita, K Tamura, N Hirawa, Y Toya, S Umemura

    HYPERTENSION RESEARCH   26 ( 2 )   177 - 184   2003.2

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  • Effects of the anti-platelet aggregation drug dilazep on cognitive function in Dahl salt-sensitive rats Reviewed

    A Numabe, N Ara, R Hakamada-Taguchi, N Suzuki, N Hirawa, Y Kawabata, T Negoro, T Nagata, A Goto, T Toyo-Oka, T Fujita, Y Uehara

    HYPERTENSION RESEARCH   26 ( 2 )   185 - 191   2003.2

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    DOI: 10.1291/hypres.26.185

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  • Effects of cyclosporin a on renal function in patients with steroid-resistant nephrotic syndrome Reviewed

    N Ogawa, G Shimura, G Yasuda, T Iwamoto, K Tamura, N Hirawa, Y Toya, M Kihara, K Hasegawa, Y Ikeda, K Shibuya, Y Tokita, T Kuji, S Umemura

    9TH ASIAN PACIFIC CONGRESS OF NEPHROLOGY   93 - 94   2003

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  • Safety and efficacy of a biliary-excreted angiotensin converting enzyme (ACE) inhibitor, temocapril, in combination with amlodipine in advanced diabetic nephropathy Reviewed

    Gen Yasuda, Tadashi Kuji, Kyoko Hasegawa, Nobuhito Hirawa, Minoru Kihara, Yoshiyuki Toya, Hiroshi Shionoiri, Satoshi Umemura

    Clinical and Experimental Nephrology   6 ( 4 )   229 - 236   2002.12

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    DOI: 10.1007/s101570200039

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  • 新しい腎疾患マーカーとしての尿中リポカリン型プロスタグランジンD合成酵素(L-PGDS) 尿中L-PGDSの臨床意義について(1)

    織田 浩司, 土田 貴正, 清木 興介, 椎名 康彦, 佐藤 信行, 申 偉秀, 戸塚 康男, 濱野 久美子, 安島 美保, 秋山 義隆, 作家 有実子, 五味 朋子, 池田 寿男, 高木 正雄, 山門 実, 高橋 英孝, 沼部 敦司, 梅村 敏, 平和 伸仁, 池田 弓子, 常田 康夫, 四方 賢一, 和田 淳, 高橋 健二, 谷合 一陽, 尾山 秀樹, 松岡 孝, 江口 豊, 江口 直美, 上原 誉志夫, 槇野 博史, 裏出 良博

    臨床化学   31 ( Suppl.1 )   87a - 87a   2002.9

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  • Blood sugar control reverses the increase in urinary excretion of prostaglandin D synthase in diabetic patients Reviewed

    K Hamano, Y Totsuka, M Ajima, T Gomi, T Ikeda, N Hirawa, Y Eguchi, M Yamakado, M Takagi, H Nakajima, H Oda, K Seiki, N Eguchi, Y Urade, Y Uehara

    NEPHRON   92 ( 1 )   77 - 85   2002.9

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  • 新しい腎疾患マーカーとしての尿中リポカリン型プロスタグランジンD合成酵素(L-PGDS) 尿中L-PGDSの臨床意義について(2)

    清木 興介, 織田 浩司, 椎名 康彦, 土田 貴正, 佐藤 信行, 申 偉秀, 戸塚 康男, 濱野 久美子, 安島 美保, 秋山 義隆, 作家 有実子, 五味 朋子, 池田 寿男, 高木 正雄, 山門 実, 高橋 英孝, 沼部 敦司, 梅村 敏, 平和 伸仁, 池田 弓子, 常田 康夫, 四方 賢一, 和田 淳, 高橋 健二, 谷合 一陽, 尾山 秀樹, 松岡 孝, 江口 豊, 江口 直美, 上原 誉志夫, 槇野 博史, 裏出 良博

    臨床化学   31 ( Suppl.1 )   77a - 77a   2002.9

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  • Lipocalin-type prostaglandin D synthase in essential hypertension Reviewed

    N Hirawa, Y Uehara, M Yamakado, Y Toya, T Gomi, T Ikeda, Y Eguchi, M Takagi, H Oda, K Seiki, Y Urade, S Umemura

    HYPERTENSION   39 ( 2 )   449 - 454   2002.2

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    DOI: 10.1161/hy0202.102835

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  • 本態性高血圧患者におけるリポカリン型プロスタグランジンD合成酵素について

    平和 伸仁

    高血圧   39 (2 pt 2) ( 449 )   6   2002

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  • Impaired renal function in a patient with diuretic abuse Reviewed

    Gen Yasuda, Toshikazu Takizawa, Kazuhiko Shibata, Nobuhito Hirawa, Minoru Kihara, Yoshiyuki Toya, Hiroshi Shionoiri, Satoshi Umemura

    Clinical and Experimental Nephrology   6 ( 1 )   67 - 70   2002

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    DOI: 10.1007/s101570200010

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  • Urinary prostaglandin D synthase (beta-trace) excretion increases in the early stage of diabetes mellitus

    N Hirawa, Y Uehara, T Ikeda, T Gomi, K Hamano, Y Totsuka, M Yamakado, M Takagi, N Eguchi, H Oda, K Seiki, H Nakajima, Y Urade

    NEPHRON   87 ( 4 )   321 - 327   2001.4

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  • Long-term inhibition of renin-angiotensin system sustains memory function in aged Dahl rats

    N Hirawa, Y Uehara, Y Kawabata, A Numabe, T Comi, T Ikeda, T Suzuki, A Goto, T Toyo-Oka, M Omata

    HYPERTENSION   34 ( 3 )   496 - 502   1999.9

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  • High salt intake potentiates the renal vascular and glomerular damage caused by low doses of angiotensin II in uni-nephrectomized rats

    N Hirawa, Y Uehara, Y Kawabata, A Numabe, N Ogawa, T Gomi, T Ikeda, A Goto, T Toyo-oka, M Omata

    JOURNAL OF HYPERTENSION   17 ( 7 )   923 - 932   1999.7

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    DOI: 10.1097/00004872-199917070-00008

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  • Regression of glomerular injury by kallikrein infusion in Dahl salt-sensitive rats is a bradykinin B-2-receptor-mediated event

    N Hirawa, Y Uehara, T Suzuki, Y Kawabata, A Numabe, T Gomi, T Ikeda, K Kizuki, M Omata

    NEPHRON   81 ( 2 )   183 - 193   1999.2

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    DOI: 10.1159/000045275

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  • Angiotensin II subtype-1 receptor antagonists improve hemodynamic and renal changes without affecting glucose metabolisms in genetic rat model of non-insulin-dependent diabetes mellitus

    Y Uehara, N Hirawa, Y Kawabata, A Numabe, T Gomi, T Ikeda, M Omata

    AMERICAN JOURNAL OF HYPERTENSION   12 ( 1 )   21 - 27   1999.1

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    DOI: 10.1016/S0895-7061(98)00276-3

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  • Strict dietary sodium reduction worsens insulin sensitivity by increasing sympathetic nervous activity in patients with primary hypertension

    T Gomi, Y Shibuya, J Sakurai, N Hirawa, K Hasegawa, T Ikeda

    AMERICAN JOURNAL OF HYPERTENSION   11 ( 9 )   1048 - 1055   1998.9

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    DOI: 10.1016/S0895-7061(98)00126-5

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  • Renal, intestinal, and adrenal responses to sodium loading in Dahl-Iwai salt-sensitive and salt-resistant rats Reviewed

    Yoshio Katoh, Satoshi Umemura, Koh-Ichi Sugimoto, Masakazu Tomiyama, Yasuhiko Abe, Nobuhito Hirawa, Masao Ishii

    Japanese Heart Journal   39 ( 1 )   109 - 119   1998

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    DOI: 10.1536/ihj.39.109

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  • Angiotensin-converting enzyme inhibition delays onset of glucosuria with regression of renal injuries in genetic rat model of non-insulin-dependent diabetes mellitus Reviewed

    Y. Uehara, N. Hirawa, A. Numabe, Y. Kawabata, H. Nagoshi, H. Negoro, S. Fujiwara, T. Gomi, T. Ikeda, A. Goto, M. Omata

    Journal of Cardiovascular Pharmacology and Therapeutics   3 ( 4 )   327 - 335   1998

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    DOI: 10.1177/107424849800300408

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  • The implication of renin-angiotensin system on renal injury seen in Dahl salt-sensitive rats Reviewed

    N Hirawa, Y Uehara, A Numabe, Y Kawabata, T Gomi, T Ikeda, T Ohnishi, M Ishii, M Omata

    AMERICAN JOURNAL OF HYPERTENSION   10 ( 5 )   S102 - S106   1997.5

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  • Long-term infusion of kallikrein attenuates renal injury in Dahl salt-sensitive rats Reviewed

    Y Uehara, N Hirawa, A Numabe, Y Kawabata, T Ikeda, T Gomi, A Gotoh, M Omata

    AMERICAN JOURNAL OF HYPERTENSION   10 ( 5 )   S83 - S88   1997.5

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  • Thromboxane inhibition potentiates antihypertensive effects of alpha(1) adrenoceptor antagonists in the rat Reviewed

    S Takada, A Numabe, N Hirawa, S Yagi, Y Uehara

    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS   56 ( 2 )   127 - 134   1997.2

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  • Serum N-acetyl-β-D-glucosaminidase activity in a genetic rat model of non-insulin-dependent diabetes mellitus

    Yoshio Uehara, Nobuhito Hirawa, Yukari Kawabata, Atsushi Numabe, Hiroshi Nagoshi, Tomoko Gomi, Toshio Ikeda, Atsuo Goto, Teruhiko Toyo-oka, Masao Omata

    Hypertension Research   20 ( 3 )   193 - 199   1997

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    DOI: 10.1291/hypres.20.193

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  • Immunosuppressant HR-325 attenuates progression of malignant arteritis in the kidney of Dahl salt-sensitive rats Reviewed

    Yoshio Uehara, Nobuhito Hirawa, Yukari Kawabata, Yasuki Akie, Atsuko Ichikawa, Norio Funahashi, Masao Omata

    Hypertension Research   20 ( 2 )   91 - 97   1997

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    DOI: 10.1291/hypres.20.91

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  • Lipid metabolism and renal protection by chronic cicletanine treatment in Dahl salt-sensitive rats with salt-induced hypertension Reviewed

    Yoshio Uehara, Nobuhito Hirawa, Yukari Kawabata, Yasuki Akie, Atsuko Ichikawa, Norio Funahashi, Atsuo Goto, Masao Omata

    Blood Pressure   6 ( 3 )   180 - 187   1997

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    DOI: 10.3109/08037059709061935

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  • Adenosine A(1) receptor and its gene expression in ventricles from spontaneously hypertensive rats Reviewed

    S Kobayashi, S Umemura, Y Toya, N Hirawa, S Hayashi, K Uchino, M Ishii

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   271 ( 3 )   R704 - R709   1996.9

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  • Improvement of insulin sensitivity contributes to blood pressure reduction after weight loss in hypertensive subjects with obesity Reviewed

    T Ikeda, T Gomi, N Hirawa, J Sakurai, N Yoshikawa

    HYPERTENSION   27 ( 5 )   1180 - 1186   1996.5

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  • A case report of angioedema during long-term (66 months) angiotensin converting enzyme inhibition therapy with enalapril Reviewed

    H Shionoiri, Takasaki, I, N Hirawa, M Kihara, E Gotoh, T Sasaki, H Nakajima, M Ishii

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   60 ( 3 )   166 - 170   1996.3

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  • Hachimi-jio-gan extract protects the kidney from hypertensive injury in Dahl salt-sensitive rat

    N Hirawa, Y Uehara, Y Kawabata, A Numabe, S Takada, H Nagoshi, T Gomi, T Ikeda, M Omata

    AMERICAN JOURNAL OF CHINESE MEDICINE   24 ( 3-4 )   241 - 254   1996

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  • Restoration of endothelial cell function by chronic cicletanine treatment in Dahl salt-sensitive rats with salt-induced hypertension Reviewed

    Nobuhito Hirawa, Yoshio Uehara, Yukari Kawabata, Yasuki Akie, Atsuko Ichikawa, Norio Funahashi, Atsuo Goto, Masao Oniata

    Hypertension Research - Clinical and Experimental   19 ( 4 )   263 - 270   1996

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    DOI: 10.1291/hypres.19.263

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  • A new adenosine subtype-1 receptor antagonist, FK-838, attenuates salt-induced hypertension in Dahl salt-sensitive rats Reviewed

    Y Uehara, A Numabe, N Hirawa, Y Kawabata, H Nagoshi, H Kaneko, T Gomi, A Goto, T Toyooka, M Omata

    AMERICAN JOURNAL OF HYPERTENSION   8 ( 12 )   1189 - 1199   1995.12

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  • ALPHA(1)-ADRENERGIC RECEPTORS IN CARDIAC VENTRICLES OF DAHL RATS Reviewed

    S HAYASHI, S UMEMURA, K ASHINO, N HIRAWA, Y TOYA, Y ABE, M ISHII

    AMERICAN JOURNAL OF HYPERTENSION   8 ( 8 )   850 - 854   1995.8

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  • SUBPRESSOR DOSE OF ANGIOTENSIN-II INCREASES SUSCEPTIBILITY TO THE HEMODYNAMIC INJURY OF BLOOD-PRESSURE IN DAHL SALT-SENSITIVE RATS

    N HIRAWA, Y UEHARA, Y KAWABATA, A NUMABE, N OHSHIMA, H ONO, T GOMI, T IKEDA, S YAGI, T TOYOOKA, M OMATA

    JOURNAL OF HYPERTENSION   13 ( 1 )   81 - 90   1995.1

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  • EFFECT OF GREEN TEA RICH IN GAMMA-AMINOBUTYRIC-ACID ON BLOOD-PRESSURE OF DAHL SALT-SENSITIVE RATS Reviewed

    Y ABE, S UMEMURA, K SUGIMOTO, N HIRAWA, Y KATO, N YOKOYAMA, T YOKOYAMA, J IWAI, M ISHII

    AMERICAN JOURNAL OF HYPERTENSION   8 ( 1 )   74 - 79   1995.1

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  • Possible Linkage between Renal Injury and Cardiac Remodeling in Dahl Salt-Sensitive Rats Treated with the Calcium Channel Antagonist Benidipine Reviewed

    Yoshio Uehara, Yukari Kawabata, Hiroshi Nagoshi, Atsuo Goto, Masao Omata, Nobuhito Hirawa, Tomoko Gomi, Tsuyoshi Takeda, Jiro Ikegami, Atsushi Numabe

    Hypertension Research - Clinical and Experimental   18 ( 3 )   245 - 253   1995

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    DOI: 10.1291/hypres.18.245

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  • LONG-TERM INFUSION OF KALLIKREIN ATTENUATES RENAL INJURY IN DAHL SALT-SENSITIVE RATS Reviewed

    Y UEHARA, N HIRAWA, Y KAWABATA, T SUZUKI, N OHSHIMA, K OKA, T IKEDA, A GOTO, T TOYOOKA, K KIZUKI, M OMATA

    HYPERTENSION   24 ( 6 )   770 - 778   1994.12

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  • ANTIHYPERTENSIVE EFFECTS OF 2-OCTYNYLADENOSINE (YT-146), A SELECTIVE ADENOSINE A(2) RECEPTOR AGONIST, IN DAHL SALT-SENSITIVE RATS Reviewed

    T IWAMOTO, S UMEMURA, Y TOYA, N HIRAWA, K TAKEDA, M KIHARA, M ISHII

    AMERICAN JOURNAL OF HYPERTENSION   7 ( 11 )   984 - 988   1994.11

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  • MECHANISTIC ANALYSIS OF RENAL PROTECTION BY ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR IN DAHL SALT-SENSITIVE RATS Reviewed

    N HIRAWA, Y UEHARA, Y KAWABATA, N OHSHIMA, H ONO, T NAGATA, T GOMI, T IKEDA, A GOTO, S YAGI, M OMATA

    JOURNAL OF HYPERTENSION   12 ( 8 )   909 - 918   1994.8

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  • RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISMS OF ALPHA(2)-ADRENOCEPTOR GENES AND BLOOD-PRESSURE IN GENETIC-HYPERTENSION Reviewed

    S UMEMURA, S KOBAYASHI, N HIRAWA, S YAMAGUCHI, T IWAMOTO, K TAMURA, M ISHII

    JAPANESE HEART JOURNAL   35 ( 4 )   502 - 503   1994.7

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  • NEW DIHYDROPYRIDINE CALCIUM-CHANNEL ANTAGONIST, PRANIDIPINE, ATTENUATES HYPERTENSIVE RENAL INJURY IN DAHL SALT-SENSITIVE RATS Reviewed

    Y UEHARA, Y KAWABATA, N OHSHIMA, N HIRAWA, S TAKADA, A NUMABE, T NAGATA, A GOTO, S YAGI, M OMATA

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   23 ( 6 )   970 - 979   1994.6

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  • VASOCONSTRICTORS AND RENAL PROTECTION INDUCED BY BETA(1)-SELECTIVE ADRENOCEPTOR ANTAGONIST BISOPROLOL Reviewed

    Y UEHARA, S TAKADA, N HIRAWA, Y KAWABATA, N OHSHIMA, A NUMABE, T ISHIMITSU, A GOTO, S YAGI, M OMATA

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   23 ( 6 )   897 - 906   1994.6

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  • DDE-I RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM OF THE ALPHA-2-ADRENOCEPTOR GENE DOES NOT CORRELATE WITH BLOOD-PRESSURE IN THE F2 GENERATION OBTAINED FROM CROSSING STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS AND WISTAR-KYOTO RATS Reviewed

    S KOBAYASHI, S UMEMURA, N HIRAWA, T IWAMOTO, S YAMAGUCHI, K TAMURA, TAKASAKI, I, M ISHII

    JOURNAL OF HYPERTENSION   12 ( 3 )   235 - 238   1994.3

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  • ASSOCIATION ANALYSIS OF RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM FOR ALPHA(2)-ADRENERGIC RECEPTOR GENES IN ESSENTIAL-HYPERTENSION IN JAPAN Reviewed

    S UMEMURA, N HIRAWA, T IWAMOTO, S YAMAGUCHI, Y TOYA, S KOBAYASHI, TAKASAKI, I, G YASUDA, K TAMURA, M ISHII, L SUN, WA PETTINGER

    HYPERTENSION   23 ( 1 )   I203 - I206   1994.1

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  • Changes in platelet calcium ion (Ca2+) during hemodialysis.

    TAKAGI N, HIRAWA N, TOKITA Y, TAKEDA K, TAMURA K, IWAMOTO T, YAMAGUCHI S, ISHII M

    Jinko Zoki   23 ( 2 )   429 - 434   1994

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    In this study, we measured the platelet concentration of calcium ions (Ca2+) and thrombin-stimulated platelet Ca2+ increases during hemodialysis in 33 patients (19 male, 14 female, mean age 55.2±2.3 years) with chronic ronal failire. The following results were obtained:1)Just after hemodialysis with a semi-synthetic membrane dialyzer, platelet Ca2+ increased significantly. However, this did not occur during hemodialysis with a synthetic menbrane dializer or during extra-corporeal ultrafiltration with both menbrane dialyzers. 2)The increase in platelet Ca2+ by thrombin stimulation at a dose ...

    DOI: 10.11392/jsao1972.23.429

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  • INHIBITION OF PROTEIN-SYNTHESIS AND ANTIPROLIFERATIVE EFFECT OF THE ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR TRANDOLAPRILAT IN RAT VASCULAR SMOOTH-MUSCLE CELLS Reviewed

    Y UEHARA, A NUMABE, Y KAWABATA, S TAKADA, N HIRAWA, T NAGATA, T IKEDA, S YAGI, M OMATA

    JOURNAL OF HYPERTENSION   11 ( 10 )   1073 - 1081   1993.10

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  • DE-NOVO SYNTHESIS OF PHOSPHOLIPASE-A(2) AND PROSTACYCLIN PRODUCTION BY PROLIFERATING RAT SMOOTH-MUSCLE CELLS Reviewed

    Y UEHARA, S TAKADA, N HIRAWA, Y KAWABATA, T NAGATA, A NUMABE, H HARA, KUDO, I, T IKEDA, K INOUE, T SUGIMOTO, M OMATA

    PROSTAGLANDINS   46 ( 4 )   331 - 346   1993.10

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  • CHARACTERISTIC LOCALIZATION OF ALPHA(1)-ADRENOCEPTORS AND ALPHA(2)-ADRENOCEPTORS IN THE HUMAN KIDNEY Reviewed

    K MINAMISAWA, S UMEMURA, N HIRAWA, S HAYASHI, Y TOYA, Y ISHIKAWA, G YASUDA, M ISHII

    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY   20 ( 7-8 )   523 - 526   1993.7

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  • POSSIBLE RADICAL SCAVENGING PROPERTIES OF CICLETANINE AND RENAL PROTECTION IN DAHL SALT-SENSITIVE RATS Reviewed

    Y UEHARA, Y KAWABATA, N HIRAWA, S TAKADA, T NAGATA, A NUMABE, J IWAI, T SUGIMOTO

    AMERICAN JOURNAL OF HYPERTENSION   6 ( 6 )   463 - 472   1993.6

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  • IDENTIFICATION AND CHARACTERIZATION OF ADENOSINE-A1 RECEPTOR-CAMP SYSTEM IN HUMAN GLOMERULI Reviewed

    Y TOYA, S UMEMURA, T IWAMOTO, N HIRAWA, M KIHARA, N TAKAGI, M ISHII

    KIDNEY INTERNATIONAL   43 ( 4 )   928 - 932   1993.4

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  • Alterations in Receptor-Mediated Activation of Phospholipase A2 in DAHL Salt-Sensitive Rats Reviewed

    Yoshio Uehara, Yukari Kawabata, Masao Omata, Satoru Takada, Nobuhito Hirawa, Junichi Iwai, Shuntaro Hara, Ichiro Kudo, Keizo Inoue

    Hypertension Research   16 ( 2 )   105 - 111   1993

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    DOI: 10.1291/hypres.16.105

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  • 3 cases of adult Still's disease with excellence by double-filtration plasma exchange therapy.

    Nihon Naika Gakkai Zasshi   82 ( 10 )   1713 - 1714   1993

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    DOI: 10.2169/naika.82.1713

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  • REGULATORY EFFECT OF THROMBOXANE-A2 ON PROLIFERATION OF VASCULAR SMOOTH-MUSCLE CELLS FROM RATS Reviewed

    T NAGATA, Y UEHARA, A NUMABE, T ISHIMITSU, N HIRAWA, T IKEDA, H MATSUOKA, T SUGIMOTO

    AMERICAN JOURNAL OF PHYSIOLOGY   263 ( 5 )   H1331 - H1338   1992.11

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  • EFFECT OF DIETARY-SODIUM ON PLATELET ALPHA(2)-ADRENOCEPTORS IN YOUNG NORMOTENSIVE MEN WITH OR WITHOUT A FAMILY HISTORY OF HYPERTENSION Reviewed

    S UMEMURA, N HIRAWA, S HAYASHI, Y TOYA, K MINAMISAWA, T IWAMOTO, M KIHARA, M ISHII

    JOURNAL OF HYPERTENSION   10 ( 11 )   1397 - 1401   1992.11

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  • ENHANCED INHIBITORY EFFECT OF ALPHA-2-ADRENOCEPTOR STIMULATION ON THE FORMATION OF CAMP IN GLOMERULI OF SPONTANEOUSLY HYPERTENSIVE RATS Reviewed

    Y LIU, S UMEMURA, N HIRAWA, Y TOYA, K MINAMISAWA, T IWAMOTO, M ISHII

    AMERICAN JOURNAL OF HYPERTENSION   5 ( 8 )   511 - 514   1992.8

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  • RENIN GENE-EXPRESSION IN THE ADRENAL AND KIDNEY OF PATIENTS WITH PRIMARY ALDOSTERONISM Reviewed

    H SHIONOIRI, N HIRAWA, SI UEDA, H HIMENO, E GOTOH, K NOGUCHI, A FUKAMIZU, MS SEO, K MURAKAMI

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   74 ( 1 )   103 - 107   1992.1

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  • THE EFFECTS OF A K+ CHANNEL OPENER, BRL-38227, ON BLOOD-PRESSURE AND VASCULAR THROMBOXANE-A2 GENERATION IN DAHL SALT-SENSITIVE RATS Reviewed

    N HIRAWA, S UMEMURA, Y TOKITA, Y TOYA, K SUGIMOTO, N TAKAGI, Y KATO, T IKEDA, M ISHII

    GENETIC HYPERTENSION   218   289 - 291   1992

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  • BIPHASIC EFFECTS OF AN ADENOSINE ANALOG ON THE CYCLIC-AMP FORMATION IN ISOLATED RAT GLOMERULI Reviewed

    Y LIU, S UMEMURA, N HIRAWA, Y TOYA, M KIHARA, T IWAMOTO, S HAYASHI, K TAKEDA, S YOUNG, M ISHII

    GENETIC HYPERTENSION   218   487 - 489   1992

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  • Pharmacodynamics in hypertensive patients of an ACE inhibitor, benazepril.

    Jpn. J. Clin. Pharmacol. Ther.   23 ( 1 )   137 - 138   1992

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    DOI: 10.3999/jscpt.23.137

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    Other Link: http://search.jamas.or.jp/link/ui/1993002732

  • STIMULATING EFFECTS OF ATENOLOL ON VASODEPRESSOR PROSTAGLANDIN GENERATION IN SPONTANEOUSLY HYPERTENSIVE RATS

    N HIRAWA, Y UEHARA, A NUMABE, S TAKADA, H MATSUOKA, T IKEDA, T SUGIMOTO, S YAGI, M ISHII

    CLINICAL SCIENCE   81 ( 4 )   499 - 507   1991.10

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  • POSSIBLE ROLE OF PROSTACYCLIN SYNTHASE IN ALTERED PROSTACYCLIN GENERATION IN DOCA-SALT HYPERTENSIVE RATS Reviewed

    Y UEHARA, A NUMABE, S TAKADA, N HIRAWA, T NAGATA, T ISHIMITSU, T SUGIMOTO, S YAGI

    AMERICAN JOURNAL OF HYPERTENSION   4 ( 8 )   667 - 673   1991.8

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  • INHIBITORY EFFECTS OF BETA ADRENOCEPTOR ANTAGONIST, ATENOLOL, ON THE THROMBOXANE SYSTEM IN THE KIDNEY OF SPONTANEOUSLY HYPERTENSIVE RATS Reviewed

    N HIRAWA, Y UEHARA, A NUMABE, T IKEDA, S YAGI, T SUGIMOTO, M ISHII

    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS   43 ( 2 )   93 - 98   1991.6

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  • ALTERED PHOSPHOLIPASE-C ACTIVITY IN RENAL MEDULLA OF DOCA-SALT HYPERTENSIVE RATS Reviewed

    Y UEHARA, A NUMABE, S TAKADA, N HIRAWA, H MATSUOKA, T IKEDA, S YAGI, T SUGIMOTO

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   55 ( 5 )   509 - 515   1991.5

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  • Neurilemoma of the retroperitoneum Reviewed

    M. Kihara, S. Umemura, N. Takagi, N. Hirawa, K. Minamisawa, T. Matsukawa, E. Miyajima, H. Shionoiri, M. Ishii

    Klinische Wochenschrift   69 ( 5 )   228 - 231   1991.3

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    DOI: 10.1007/BF01646948

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  • IDENTIFICATION OF AN ALPHA2-ADRENOCEPTOR IN HUMAN CORONARY-ARTERIES BY RADIOLIGAND BINDING ASSAY Reviewed

    Y ISHIKAWA, S UMEMURA, K UCHINO, T SHINDOU, G YASUDA, K MINAMISAWA, S HAYASHI, N HIRAWA, M ISHII

    LIFE SCIENCES   48 ( 26 )   2513 - 2518   1991

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  • ANTIPROLIFERATIVE EFFECTS OF THE SEROTONIN TYPE-2 RECEPTOR ANTAGONIST, KETANSERIN, ON SMOOTH-MUSCLE CELL-GROWTH IN RATS Reviewed

    Y UEHARA, T NAGATA, H MATSUOKA, A NUMABE, N HIRAWA, S TAKADA, T ISHIMITSU, S YAGI, T SUGIMOTO

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   17   S154 - S156   1991

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  • Blood pressure during waking and sleeping in patients with mild essential hypertension

    O. Tochikubo, E. Miyajima, K. Minamisawa, Y. Yamada, T. Matsukawa, N. Hirawa, Y. Yoshida, M. Ishii

    Therapeutic Research   11 ( 7 )   39 - 49   1990

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  • Measurement of plasma active renin by solid phase radioimmunoassay using monoclonal antibodies Reviewed

    H. Shionoiri, I. Takasaki, Y. Ishikawa, K. Minamisawa, K. I. Sugimoto, N. Hirawa, S. I. Ueda, E. Gotoh

    American Journal of the Medical Sciences   300 ( 3 )   138 - 143   1990

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    DOI: 10.1097/00000441-199009000-00002

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  • EFFECTS OF THIAZIDE DIURETIC ON VASCULAR EICOSANOID SYSTEM OF SPONTANEOUSLY HYPERTENSIVE RATS Reviewed

    A NUMABE, Y UEHARA, N HIRAWA, S TAKADA, S YAGI

    JOURNAL OF HYPERTENSION   7 ( 6 )   493 - 499   1989.6

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  • INHIBITORY EFFECT OF HUMAN ATRIAL NATRIURETIC PEPTIDE ON CYCLIC-AMP LEVELS IN MICRODISSECTED HUMAN GLOMERULI Reviewed

    S UMEMURA, Y TOYA, N HIRAWA, Y ISHIKAWA, K MINAMIZAWA, G YASUDA, S HAYASHI, M ISHII

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   13   S36 - S38   1989

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  • Functional atrial natriuretic peptide receptor in human adrenal tumor Reviewed

    H. Shionoiri, N. Hirawa, I. Takasaki, Y. Ishikawa, H. Oda, K. Minamisawa, K. Sugimoto, T. Matsukawa, S. Ueda, E. Miyajima, S. Umemura, E. Gotoh, M. Ishii, M. Ishido, M. Shimonaka, S. Hirose

    Journal of Cardiovascular Pharmacology   13 ( 6 )   S9 - S12   1989

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    DOI: 10.1097/00005344-198905006-00004

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  • Roles of vascular and renal thromboxanes in the antihypertensive effects of α1 adrenoceptor antagonist Reviewed

    Satoru Takada, Atsushi Numabe, Shigeru Yagi, Yoshio Uehara, Nobuhito Hirawa

    Japanese Journal of Nephrology   31 ( 9 )   969 - 975   1989

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    DOI: 10.14842/jpnjnephrol1959.31.969

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  • The effects of ketanserin on vascular eicosanoid system in spontaneously hypertensive rats and their implications Reviewed

    Yoshio Uehara, Atsushi Numabe, Nobuhito Hirawa, Toshihiko Ishimitsu, Satoru Takada, Hiroaki Matsuoka, Shigeru Yagi, Tsuneaki Sugimoto

    The Japanese Journal of Nephrology   31 ( 1 )   31 - 37   1989

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    DOI: 10.14842/jpnjnephrol1959.31.31

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  • ALPHA-2-ADRENOCEPTOR STIMULATION INHIBITS CELLULAR CYCLIC-AMP PRODUCTION IN MICRODISSECTED HUMAN GLOMERULI Reviewed

    S UMEMURA, N HIRAWA, Y TOYA, K MINAMIZAWA, G YASUDA, Y ISHIKAWA, S HAYASHI, M ISHII

    CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE   11   275 - 280   1989

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  • Alpha 2-adrenoceptor stimulation inhibits cellular cyclic AMP production in microdissected human glomeruli Reviewed

    S. Umemura, N. Hirawa, Y. Toya, K. Minamizawa, G. Yasuda, Y. Ishikawa, S. Hayashi, M. Ishii

    Clinical and Experimental Hypertension   A11 ( 1 )   275 - 280   1989

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    DOI: 10.3109/10641968909045431

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  • ALTERATIONS TO THE VASCULAR VASODEPRESSOR PROSTAGLANDIN SYSTEM IN DOCA-SALT HYPERTENSIVE RATS AND THEIR ENZYMATIC ANALYSIS Reviewed

    Y UEHARA, A NUMABE, N HIRAWA, T ISHIMITSU, S TAKADA, T SUGIMOTO, S YAGI

    JOURNAL OF HYPERTENSION   6   S392 - S394   1988.12

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  • Lack of atrial natriuretic peptide receptors in human aldosteronoma Reviewed

    H. Shionoiri, N. Hirawa, I. Takasaki, Y. Ishikawa, H. Oda, E. Gotoh, M. Hosaka, M. Shimonaka, M. Ishido, S. Hirose

    Biochemical and Biophysical Research Communications   152 ( 1 )   37 - 43   1988.4

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    DOI: 10.1016/S0006-291X(88)80676-4

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  • Effects of thiazide diuretic on vascular eicosanoid system of spontaneously hypertensive rats and their mechanisms Reviewed

    Atsushi Numabe, Yosiiio Ueiiara, Nobuhito Hirawa, Satoru Takada, Shigeru Yagi

    the japanese journal of nephrology   30 ( 11 )   1339 - 1347   1988

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    DOI: 10.14842/jpnjnephrol1959.30.1339

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  • Alterations to the vascular vasodepressor prostaglandin system in DOCA-salt hypertensive rats and their enzymatic analysis Reviewed

    Yoshio Uehara, Atsushi Numabe, Nobuhito Hirawa, Toshihiko Ishimitsu, Satoru Takada, Tsuneaki Sugimoto, Shigeru Vagi

    Journal of Hypertension, Supplement   6 ( 4 )   S392 - S394   1988

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  • Presence of functional receptors for atrial natriuretic peptide in human pheochromocytoma Reviewed

    H. Shionoiri, N. Hirawa, I. Takasaki, Y. Ishikawa, K. Minamisawa, E. Miyajima, Y. Kinoshita, K. Shimoyama, M. Shimonaka, M. Ishido, S. Hirose

    Biochemical and Biophysical Research Communications   148 ( 1 )   286 - 291   1987.10

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    DOI: 10.1016/0006-291X(87)91108-9

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MISC

  • The JSH Morning Hypertension Eradication Program Project

    Kazuomi Kario, Akira Nishiyama, Shigeru Shibata, Masaki Mogi, Hisatomi Arima, Takuya Kishi, Mari Ishida, Masato Furuhashi, Atsuhiro Ichihara, Tomohiro Katsuya, Katsuyuki Miura, Shin-ichiro Miura, Mitsuru Ohishi, Hirotaka Shibata, Tatsuo Shimosawa, Akira Sugawara, Kouichi Tamura, Kazunori Toyoda, Koichi Yamamoto, Satoshi Hoshide, Naoki Nakagawa, Hirofumi Tomita, Atsushi Tanaka, Atsushi Hozawa, Tsuguru Hatta, Akihiro Nomura, Mai Kabayama, Hiromi Rakugi, Yusuke Ohya, Koichi Node, Hisashi Kai, Kimika Arakawa, Wakako Kawarazaki, Tomonori Okamura, Yukari Takemi, Hidehiro Kaneko, Keisuke Shinohara, Nobuhito Hirawa, Atsushi Sakima, Takayoshi Ohkubo, Kei Asayama, Naoko Tomitani

    HYPERTENSION RESEARCH   2025.8

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    DOI: 10.1038/s41440-025-02330-9

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  • 高度慢性腎臓病におけるサクビトリルバルサルタンの24時間血圧への有効性

    金口翔, 石賀浩平, 涌井広道, 平和伸仁, 田村功一

    日本内科学会雑誌   114   2025

  • A SINGLE-CENTER, RETROSPECTIVE STUDY OF BLOOD PRESSURE EFFECTS OF DAPAGLIFLOZIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE

    Rina Kawano, Nobuhito Hirawa, Aiko Haruna, Moe Ozawa, Tatsuya Haze, Shota Suzuki, Yuki Ohki, Yusuke Kobayashi, Akira Fujiwara, Sanae Saka, Kouichi Tamura

    JOURNAL OF HYPERTENSION   41   E416 - E416   2023.1

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  • THE ASSOCIATION BETWEEN FRAILTY OR SARCOPENIA AND INTRADIALYTIC HYPOTENSION

    Moe Ozawa, Nobuhito Hirawa, Aiko Haruna, Tatsuya Haze, Rina Kawano, Shiro Komiya, Yuki Ohki, Yusuke Kobayashi, Akira Fujiwara, Sanae Saka, Masaaki Hanaoka, Hiroshi Mitsuhashi, Satoshi Yamaguchi, Toshimasa Ohnishi, Kouichi Tamura

    JOURNAL OF HYPERTENSION   41   E387 - E387   2023.1

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  • 血液透析患者における骨密度低下の割合と関連因子の検討

    畠山萌枝, 藏口裕美, 亀丸愛子, 平塚梨奈, 土師達也, 古宮士朗, 大城由紀, 鈴木将太, 藤原亮, 坂早苗, 三橋洋, 山口聡, 大西俊正, 田村功一, 平和伸仁

    日本腎臓学会誌(Web)   63 ( 4 )   2021

  • 原発性アルドステロン症における内臓脂肪組織量・皮下脂肪組織量比と腎機能障害

    土師達也, 畠山萌枝, 坂早苗, 藏口裕美, 亀丸愛子, 平塚梨奈, 古宮士朗, 大城由紀, 加納和代, 小宮麻里子, 鈴木将太, 諸宇旭純, 潘勤雅, 藤原亮, 小林麻裕美, 三橋洋, 田村功一, 平和伸仁

    日本腎臓学会誌(Web)   63 ( 4 )   2021

  • Study of LPIN1 as a new candidate gene for essential hypertension

    藤原亮, 小澤萌枝, 角田剛一郎, 平和伸仁, 谷津圭介, 土師達也, 古宮士朗, 大城由紀, 小林雄祐, 涌井広道, 田村功一

    日本高血圧学会総会プログラム・抄録集(CD-ROM)   43rd   2021

  • 慢性腎臓病におけるトルバプタンの効果についてのランダム化比較試験

    古宮士朗, 勝又真理, 蔵口裕美, 亀丸愛子, 畠山萌枝, 平塚梨奈, 土師達也, 大城由紀, 鈴木将太, 諸宇旭純, 藤原亮, 小林麻裕美, 坂早苗, 三橋洋, 田村功一, 平和伸仁

    日本腎臓学会誌(Web)   63 ( 4 )   2021

  • Present status of renal replacement therapy in Asian countries as of 2017: Vietnam, Myanmar, and Cambodia

    Toru Hyodo, Masafumi Fukagawa, Nobuhito Hirawa, Yoshitaka Isaka, Hidetomo Nakamoto, Pham Van Bui, Khin Thida Thwin, Chanseila Hy

    Renal Replacement Therapy   6 ( 1 )   2020.12

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  • プロピオチオウラシルによる薬剤性ANCA関連血管炎によってネフローゼ症候群を発症した一例

    古田里華, 鈴木将太, 亀丸愛子, 藏口裕美, 畠山萌枝, 土師達也, 平塚梨奈, 古宮士朗, 大城由紀, 藤原亮, 坂早苗, 田村功一, 平和伸仁

    日本腎臓学会誌(Web)   62 ( 6 )   2020

  • 初回の血栓性微小血管症発作で末期腎不全に至った非典型溶血性尿毒症症候群の一症例

    外澤真李, 藤原亮, 亀丸愛子, 畠山萌枝, 土師達也, 古宮士朗, 加納和代, 小宮麻里子, 鈴木将太, 諸宇旭純, 小林麻裕美, 坂早苗, 大谷方子, 田村功一, 平和伸仁

    日本腎臓学会誌(Web)   62 ( 6 )   2020

  • 梅毒によるネフローゼ症候群に抗生剤加療が奏功した一例

    亀丸愛子, 畠山萌枝, 藏口裕美, 土師達也, 平塚梨奈, 古宮士朗, 大城由紀, 鈴木将太, 藤原亮, 坂早苗, 大谷方子, 田村功一, 平和伸仁

    日本腎臓学会誌(Web)   62 ( 6 )   2020

  • Present status of renal replacement therapy in Asian countries as of 2016: Cambodia, Laos, Mongolia, Bhutan, and Indonesia

    Toru Hyodo, Masafumi Fukagawa, Nobuhito Hirawa, Matsuhiko Hayashi, Kosaku Nitta, Sovandy Chan, Phanekham Souvannamethy, Minjur Dorji, Chuluuntsetseg Dorj, I. Gde Raka Widiana

    Renal Replacement Therapy   5 ( 1 )   2019.3

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  • 造血幹細胞移植後に慢性移植片対宿主病と尿蛋白を認め,Transplant-associated thrombotic microangiopathyと考えられた症例

    土師達也, 大谷方子, 外澤真季, 畠山萌枝, 古宮士朗, 加納和代, 小宮麻里子, 鈴木将太, 諸宇旭純, 潘勤雅, 藤原亮, 小林麻裕美, 坂早苗, 平和伸仁

    腎炎症例研究(Web)   36   2019

  • 血液透析導入時に全身性強直性痙攣を呈し高血圧脳症が疑われた1例

    鈴木将太, 坂早苗, 外澤真李, 畠山萌枝, 古宮士郎, 土師達也, 藤原亮, 平和伸仁

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集(CD-ROM)   8th   2019

  • 腎移植後リンパ増殖性疾患に対する化学療法中に腫瘍崩壊症候群を呈し急性血液浄化療法を施行した一例

    外澤真李, 畠山萌枝, 土師達也, 古宮士朗, 加納和代, 小宮麻里子, 鈴木将太, 諸宇旭純, 藤原亮, 小林麻裕美, 坂早苗, 千葉佐和子, 田村功一, 平和伸仁

    日本透析医学会雑誌   52 ( Supplement 1 )   2019

  • 慢性腎臓病患者における降圧目標

    田村 功一, 涌井 広道, 畝田 一司, 小林 竜, 金岡 知彦, 大城 光二, 大澤 正人, 平和 伸仁, 戸谷 義幸, 常田 康夫

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   7回   114 - 114   2018.5

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  • 悪性高血圧により急速に腎機能低下進行し、血液透析導入となった症例

    古宮 士朗, 平和 伸仁, 畠山 萌枝, 土師 達也, 小宮 麻里子, 加納 和代, 諸宇 旭純, 藤原 亮, 小林 麻裕美, 坂 早苗, 田村 功一, 安田 元

    日本透析医学会雑誌   51 ( Suppl.1 )   746 - 746   2018.5

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  • 血液透析患者の低用量鉄投与法と標準量鉄投与法の比較

    久慈 忠司, 藤川 哲也, 金田 朋子, 西原 正博, 柴田 和彦, 薩田 英久, 井元 清隆, 川田 征一, 高口 直明, 平和 伸仁, 戸谷 義幸, 田村 功一

    日本透析医学会雑誌   51 ( Suppl.1 )   699 - 699   2018.5

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  • CERA投与下のヘプシジン変動に対する鉄剤投与の影響

    河野 知之, 藤川 哲也, 久慈 忠司, 川井 有紀, 植田 瑛子, 篠 みどり, 佐藤 陽, 三橋 洋, 小川 成章, 小田 寿, 山口 聡, 大西 俊正, 平和 伸仁, 戸谷 義幸, 田村 功一

    日本透析医学会雑誌   51 ( Suppl.1 )   700 - 700   2018.5

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  • 不明熱と傍大動脈リンパ節腫大を呈し診断に難渋した長期透析患者の一例

    藤原 亮, 平和 伸仁, 畠山 萌枝, 土師 達也, 古宮 士朗, 加納 和代, 小宮 麻里子, 諸宇 旭純, 小林 麻裕美, 坂 早苗, 田村 功一, 安田 元

    日本透析医学会雑誌   51 ( Suppl.1 )   887 - 887   2018.5

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  • 原発性アルドステロン症 診断・治療の最前線 横浜市大関連施設におけるAVS症例をまとめた自験例解析からも見えてくる、PA診断の課題と今後の提案

    谷津 圭介, 小林 雄祐, 坂 早苗, 春原 須美玲, 涌井 広道, 平和 伸仁, 田村 功一

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   7回   150 - 150   2018.5

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  • 利尿剤濫用により腎機能障害をきたし血液透析導入となった一例

    畠山 萌枝, 平和 伸仁, 土師 達也, 古宮 士朗, 加納 和代, 小宮 麻里子, 諸宇 旭純, 藤原 亮, 小林 麻裕美, 坂 早苗, 田村 功一, 安田 元

    日本透析医学会雑誌   51 ( Suppl.1 )   773 - 773   2018.5

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  • 原因不明の腎不全、全身痙攣、不明熱、腹膜透析液に対するアレルギーを認め、成人スチル病と診断した症例

    土師 達也, 平和 伸仁, 畠山 萌枝, 古宮 士朗, 森 梓, 加納 和代, 小宮 麻里子, 勝又 真理, 富岡 旭純, 藤原 亮, 小林 麻裕美, 坂 早苗, 安田 元, 田村 功一

    日本透析医学会雑誌   51 ( Suppl.1 )   836 - 836   2018.5

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  • 透析患者における生命予後と分岐鎖アミノ酸との関連に関する検討

    鈴木 将太, 篠 みどり, 藤川 哲也, 伊藤 陽子, 植田 瑛子, 畝田 一司, 橋本 達夫, 涌井 広道, 久慈 忠司, 小林 直之, 大西 俊正, 平和 伸仁, 戸谷 義幸, 田村 功一

    日本腎臓学会誌   60 ( 3 )   334 - 334   2018.4

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  • 当院においてaHUS(非典型溶血性尿毒症症候群)が疑われた4症例の検討

    藤原 亮, 平和 伸仁, 畠山 萌枝, 土師 達也, 古宮 士朗, 坂 早苗, 田村 功一, 安田 元

    日本腎臓学会誌   60 ( 3 )   451 - 451   2018.4

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  • 透析患者における生命予後と分岐鎖アミノ酸との関連に関する検討

    鈴木 将太, 篠 みどり, 藤川 哲也, 伊藤 陽子, 植田 瑛子, 畝田 一司, 橋本 達夫, 涌井 広道, 久慈 忠司, 小林 直之, 大西 俊正, 平和 伸仁, 戸谷 義幸, 田村 功一

    日本腎臓学会誌   60 ( 3 )   334 - 334   2018.4

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  • 脂肪組織移植がLPIN1欠損マウスの血圧と糖脂質代謝に与える影響

    梅原 琴乃, 角田 剛一朗, 谷津 圭介, 江原 洋介, 大城 由紀, 藤田 恵美, 藤原 亮, 小林 雄祐, 平和 伸仁, 梅村 敏, 田村 功一

    日本高血圧学会総会プログラム・抄録集   40回   366 - 366   2017.10

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  • アンジオテンシノーゲン欠損マウスにおける腎内動脈壁肥厚・間質線維化形成メカニズムの検討

    中森 悠, 吉田 伸一郎, 大澤 正人, 石黒 裕章, 鈴木 将太, 安崎 弘晃, 橋本 達夫, 石上 友章, 平和 伸仁, 戸谷 義幸, 梅村 敏, 田村 功一

    日本高血圧学会総会プログラム・抄録集   40回   360 - 360   2017.10

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  • 黄色ブドウ球菌感染後に急性腎障害をきたした感染症関連糸球体腎炎の一例

    藤原 亮, 平和 伸仁, 畠山 萌枝, 土師 達也, 古宮 士朗, 森 梓, 加納 和代, 小宮 麻里子, 諸宇 旭純, 勝又 真理, 小林 麻裕美, 坂 早苗, 大谷 方子, 田村 功一, 安田 元

    日本腎臓学会誌   59 ( 6 )   862 - 862   2017.9

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  • 医療と科学の最前線(第2回)横浜市立大学附属市民総合医療センター 腎臓・高血圧内科/血液浄化療法部

    平和 伸仁, 坂 早苗, 近藤 恵美, 小林 佳子

    尿酸と血糖 = Journal of uricemia & glycemic research   3 ( 3 )   166 - 170   2017.7

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    Other Link: http://search.jamas.or.jp/link/ui/2017304488

  • 中高年の生活習慣病患者において内臓脂肪型肥満を認めながらもBMI低値であることは動脈弾性低下、起立性低血圧のリスクである

    下木原 久美, 小林 雄祐, 小林 英雄, 藤川 哲也, 谷津 圭介, 平和 伸仁, 梅村 敏, 田村 功一

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   6回   147 - 147   2017.5

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  • CAVIと短時間心拍変動解析を用いた起立性低血圧・高血圧の病態の差異の検討

    角田 剛一朗, 小林 雄祐, 小林 英雄, 藤川 哲也, 谷津 圭介, 平和 伸仁, 梅村 敏, 田村 功一

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   6回   162 - 162   2017.5

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  • 【新薬展望2017】(第III部)治療における最近の新薬の位置付け<薬効別> 新薬の広場 高血圧治療薬

    藤原 亮, 平和 伸仁, 梅村 敏

    医薬ジャーナル   53 ( 増刊 )   437 - 445   2017.1

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  • 全身性強皮症による微小血管障害のため腎クリーゼを発症するも適切な治療により透析を離脱できた症例

    山田塁, 藤原亮, 平和伸仁, 畠山萌枝, 土師達也, 古宮士朗, 加納和代, 小宮麻里子, 諸宇旭純, 小林麻裕美, 坂早苗, 田村功一, 安田元

    日本腎臓学会誌   59 ( 6 )   2017

  • 献腎移植後に拒絶反応をきたし,心嚢液の治療に難渋した一例

    古宮士朗, 平和伸仁, 土師達也, 森梓, 勝又真理, 藤原亮, 坂早苗, 安田元, 田村功一

    日本透析医学会雑誌   50 ( Supplement 1 )   2017

  • 50回以上の再燃を繰り返す小児期発症難治性ネフローゼ症候群に対するリツキシマブ投与経験

    坂早苗, 平和伸仁, 畠山萌枝, 土師達也, 古宮士朗, 加納和代, 小宮麻里子, 諸宇旭純, 藤原亮, 小林麻裕美, 田村功一, 安田元

    日本腎臓学会誌   59 ( 6 )   2017

  • 内シャントの穿刺を契機に感染性心内膜炎をきたしたと考えられる症例

    土師達也, 平和伸仁, 古宮士朗, 森梓, 勝又真理, 藤原亮, 坂早苗, 安田元, 田村功一

    日本透析医学会雑誌   50 ( Supplement 1 )   2017

  • メトホルミンによる乳酸アシドーシスで急激な経過をたどった急性腎障害の一例

    畠山萌枝, 平和伸仁, 土師達也, 古宮士朗, 加納和代, 小宮麻里子, 諸宇旭純, 藤原亮, 小林麻裕美, 坂早苗, 田村功一, 安田元

    日本腎臓学会誌   59 ( 6 )   2017

  • 腹膜透析カテーテル抜去後に腹水貯留を認め,被嚢性腹膜硬化症を発症した一例

    古宮士朗, 平和伸仁, 畠山萌枝, 土師達也, 加納和代, 小宮麻里子, 諸宇旭純, 藤原亮, 小林麻裕美, 坂早苗, 田村功一, 安田元

    日本腎臓学会誌   59 ( 6 )   2017

  • 同種末梢血幹細胞移植後の慢性移植片対宿主病によるネフローゼ症候群の診断と治療-3症例の経過と考察-

    土師達也, 平和伸仁, 畠山萌枝, 古宮士朗, 森梓, 加納和代, 小宮麻里子, 諸宇旭純, 勝又真理, 藤原亮, 小林麻裕美, 坂早苗, 大谷方子, 田村功一, 安田元

    日本腎臓学会誌   59 ( 6 )   2017

  • Rainer TH et al : Oral Prednisolone in the Treatment of Acute Gout : A Pragmatic, Multicenter, Double-Blind, Randomized Trial

    2 ( 4 )   213 - 216   2016.10

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  • 血管平滑筋特異的ATP2B1ノックアウトマウスはCaチャネル拮抗薬に対する薬剤応答性を認めた

    奥山 由紀, 角田 剛一郎, 鍵本 美奈子, 江原 洋介, 勝又 真理, 藤田 恵美, 藤原 亮, 小林 雄祐, 坂 早苗, 谷津 圭介, 梅村 敏, 平和 伸仁

    日本高血圧学会総会プログラム・抄録集   39回   339 - 339   2016.9

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  • ATP2B1血管平滑筋過剰発現マウスの作製と解析

    江原 洋介, 角田 剛一郎, 奥山 由紀, 藤田 恵美, 勝又 真理, 藤原 亮, 小林 雄祐, 坂 早苗, 谷津 圭介, 梅村 敏, 平和 伸仁

    日本高血圧学会総会プログラム・抄録集   39回   405 - 405   2016.9

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  • Effects of pioglitazone add-on treatment on blood glucose levels and insulin resistance in patients with type 2 diabetic nephropathy receiving sitagliptin

    G. Yasuda, A. Fujiwara, S. Saka, N. Hirawa

    DIABETOLOGIA   59   S484 - S485   2016.8

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  • 腎性貧血における造血効率を考慮した適切な鉄投与タイミングの検討

    河野 知之, 藤川 哲也, 久慈 忠司, 植田 瑛子, 篠 みどり, 坂 早苗, 小嶋 啓史, 三橋 洋, 小川 成章, 小田 寿, 山口 聡, 大西 俊正, 平和 伸仁, 戸谷 義幸, 梅村 敏

    日本透析医学会雑誌   49 ( Suppl.1 )   825 - 825   2016.5

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  • EFFECT OF IRON DOSING ON IRON-RELATED PARAMETERS DURING ACTIVATED ERYTHROPOIESIS BY ERITHROPOIESIS STIMULATING AGENT IN HAEMODIALYSIS PATIENTS

    Tadashi Kuji, Tomoyuki Kawano, Eiko Ueda, Tetsuya Fujikawa, Midori Shino, Satoshi Yamaguchi, Kazuhiko Shibata, Ohnishi Toshimasa, Kouichi Tamura, Nobuhito Hirawa, Yoshiyuki Toya, Satoshi Umemura

    NEPHROLOGY DIALYSIS TRANSPLANTATION   31   274 - 274   2016.5

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  • 顕微鏡的血尿と蛋白尿を呈し、腎生検にて糸球体にmonoclonal IgM沈着を認めた一例

    勝又 真理, 平和 伸仁, 森 梓, 金口 翔, 諸宇 旭純, 山本 有一郎, 坂 早苗, 大谷 方子, 安田 元, 梅村 敏, 城 謙輔, 山口 裕

    腎炎症例研究   32   32 - 57   2016.2

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  • 高カルシウム血症を契機に診断した結核性縦隔リンパ節炎の1例

    森梓, 平和伸仁, 土師達也, 古宮士朗, 勝又真理, 藤原亮, 坂早苗, 安田元

    日本腎臓学会誌   58 ( 6 )   2016

  • 臨床的にIgA腎症が疑われるも腎生検でFSGSと診断され治療に難渋した一例

    小宮孝章, 平和伸仁, 藤原亮, 土師達也, 古宮士朗, 森梓, 勝又真理, 坂早苗, 安田元

    日本腎臓学会誌   58 ( 6 )   2016

  • 常染色体優性多発性嚢胞腎に対するトルバプタン投与を中断した患者における両腎容積の推移

    坂早苗, 平和伸仁, 土師達也, 古宮士朗, 森梓, 勝又真理, 藤原亮, 安田元

    日本腎臓学会誌   58 ( 6 )   2016

  • オムビタスビル・パリタプレビル・リトナビル配合錠投与後に高カリウム血症をきたした1例

    土師達也, 平和伸仁, 古宮士朗, 森梓, 勝又真理, 藤原亮, 坂早苗, 安田元

    日本腎臓学会誌   58 ( 6 )   2016

  • IGg4関連疾患に発症したネフローゼ症候群の1例

    古宮士朗, 平和伸仁, 土師達也, 森梓, 勝又真理, 藤原亮, 坂早苗, 安田元

    日本腎臓学会誌   58 ( 6 )   2016

  • 全身ヘテロATP2B1欠損マウスにおける高血圧と低Ca血症の関連について

    江原 洋介, 藤原 亮, 平和 伸仁, 角田 剛一郎, 奥山 由紀, 藤田 恵美, 勝又 真理, 小林 雄祐, 坂 早苗, 谷津 圭介, 戸谷 義幸, 安田 元, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   38回   374 - 374   2015.10

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  • EFFECTS OF FLUVASTATIN VERSUS PROBUCOL ON LIPID ABNORMALITIES IN NON-DIABETIC PATIENTS WITH CHRONIC KIDNEY DISEASE

    G. Yasuda, Y. Yamamoto, S. Saka, N. Hirawa

    ATHEROSCLEROSIS   241 ( 1 )   E198 - E198   2015.7

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  • 高血圧感受性遺伝ATP2B1のノックアウトマウスを用いた解析 ATP2B1遺伝子の血管内皮における血圧への影響

    奥山 由紀, 藤原 亮, 平和 伸仁, 鍵本 美奈子, 江原 洋介, 勝又 真理, 藤田 恵美, 小林 雄祐, 坂 早苗, 谷津 圭介, 戸谷 義幸, 梅村 敏

    日本臨床分子医学会学術総会プログラム・抄録集   52回   77 - 77   2015.4

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  • Therapeutic Experience of Plasmapheresis with Three Cases of Recalcitrant Bullous Pemphigoid

    Nakamura Kazuko, Matsukura Setsuko, Kono Masumi, Takahashi Kazuo, Takahashi Yukitoshi, Hirawa Nobuhito, Aihara Michiko, Kambara Takeshi

    34 ( 3 )   219 - 225   2015

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    Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by autoantibodies directed against the hemidesmosomes. Many BP patients are treated by a low-to-medium dose of systemic corticosteroid, but are sometimes refractory to such therapy. These patients are treated with a combination of therapies such as plasmapheresis, steroid pulse, high-dose gammaglobulin, and immunosuppressants. We effectively treated three recalcitrant BP patients with plasma exchange and investigated the correlation between the clinical symptoms and serum cytokine levels. Our results suggested that serum TARC, IL-6 and TNF-α levels reflect the disease activity of bullous pemphigoid. High-dose systemic corticosteroid may cause severe side effects for aged BP patients. Combination therapy with plasmapheresis should be started immediately to reduce the dose of corticosteroid in BP patients who have been unresponsive to steroid therapy.

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    Other Link: http://id.nii.ac.jp/1141/00152346/

  • 高血圧感受性遺伝子ATP2B1の血管平滑筋における役割~血管平滑筋特異的ATP2B1KOマウスを用いた降圧薬の効果比較~

    奥山由紀, 平和伸仁, 鍵本美奈子, 江原洋介, 勝又真理, 藤田恵美, 藤原亮, 小林雄祐, 坂早苗, 谷津圭介, 戸谷義幸, 梅村敏

    高血圧関連疾患モデル学会学術総会抄録集   51st   2015

  • 遠位尿細管特異的ATP2B1欠損マウスの食塩負荷による血圧変動について

    江原 洋介, 藤田 恵美, 平和 伸仁, 奥山 由紀, 勝又 真理, 藤原 亮, 坂 早苗, 小林 雄祐, 谷津 圭介, 戸谷 義幸, 安田 元, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   37回   327 - 327   2014.10

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  • 血漿シスチン値の上昇は維持血液透析患者の4年予後予測因子となりうる

    篠 みどり, 伊藤 陽子, 藤川 哲也, 横松 温子, 涌井 広道, 谷津 圭介, 橋本 達夫, 小林 直之, 田村 功一, 平和 伸仁, 大西 俊正, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   37回   372 - 372   2014.10

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  • ATP2B1遺伝子の全身ヘテロノックアウトマウスにおける臓器障害とカルシウム代謝

    藤原 亮, 平和 伸仁, 江原 洋介, 奥山 由紀, 藤田 恵美, 勝又 真理, 小林 雄祐, 坂 早苗, 谷津 圭介, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   37回   327 - 327   2014.10

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  • LPIN1欠損マウスを用いたLPIN1遺伝子の血圧の制御機能の解析

    奥山 由紀, 谷津 圭介, 江原 洋介, 勝又 真理, 藤田 恵美, 藤原 亮, 小林 雄祐, 坂 早苗, 平和 伸仁, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   37回   406 - 406   2014.10

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  • 長期にわたる遠位尿細管ATP2B1欠損がおよぼす影響 高齢マウスを用いた検討

    中山 雄太, 藤田 恵美, 平和 伸仁, 江原 洋介, 奥山 由紀, 勝又 真理, 藤原 亮, 小林 雄祐, 坂 早苗, 谷津 圭介, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   37回   404 - 404   2014.10

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  • 高血圧感受性遺伝子ATP2B1の遠位尿細管特異的欠損マウスの解析

    藤田 恵美, 平和 伸仁, 江原 洋介, 奥山 由紀, 勝又 真理, 藤原 亮, 小林 雄祐, 涌井 弘道, 坂 早苗, 谷津 圭介, 橋本 達夫, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   37回   406 - 406   2014.10

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  • 受診間血圧変動とCAVIならびに起立負荷時自律神経反応の関連性の検討

    小林 雄祐, 藤川 哲也, 小林 英雄, 奥山 由紀, 藤田 恵美, 藤原 亮, 坂 早苗, 谷津 圭介, 平和 伸仁, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   37回   347 - 347   2014.10

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  • Ca transporter(MPCA1)をコードするATP2B1のSNP多型を用いたテーラーメード医療の可能性 GEANE研究サブスタディー

    谷津 圭介, 神出 計, 平和 伸仁, 奥山 由紀, 江原 洋介, 藤田 恵美, 藤原 亮, 小林 雄祐, 坂 早苗, 戸谷 義幸, 花田 裕典, 宮田 敏行, 河野 雄平, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   37回   394 - 394   2014.10

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  • 明日から役立つ高血圧関連疾患モデル研究 遺伝子解析からモデル動物での機能解析への戦略 ATP2B1遺伝子欠損マウス

    谷津 圭介, 平和 伸仁, 奥山 由紀, 江原 洋介, 藤田 恵美, 藤原 亮, 小林 雄祐, 坂 早苗, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   37回   263 - 263   2014.10

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  • 悪性高血圧に伴う急性腎障害に対し血液透析を施行し、降圧治療に難渋するも降圧後速やかに血液透析を離脱できた一例

    坂 早苗, 平和 伸仁, 森 梓, 諸宇 旭純, 金口 翔, 勝又 真理, 山本 有一郎, 谷津 圭介, 戸谷 義幸, 安田 元, 梅村 敏

    日本急性血液浄化学会雑誌   5 ( Suppl. )   98 - 98   2014.9

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  • Cardio-renal association and Cerebro-renal association

    249 ( 9 )   757 - 763   2014.5

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  • EFFECT OF IRON DOSING ON TRANSIENT DROP IN RETICULOCYTE HEMOGLOBIN EQUIVALENT DURING ACTIVATED ERYTHROPOIESIS IN HEMODIALYSIS PATIENTS

    Tadashi Kuji, Tetsuya Fujikawa, Midori Shino, Kazuhiko Shibata, Tomoko Kaneda, Masahiro Nishihara, Hidehisa Satta, Sei-Ichi Kawata, Naoaki Koguchi, Kouichi Tamura, Nobuhito Hirawa, Yoshiyuki Toya, Satoshi Umemura

    NEPHROLOGY DIALYSIS TRANSPLANTATION   29   494 - 494   2014.5

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  • DISTAL TUBULES-SPECIFIC KNOCKOUT OF ATP2B1 IS ASSOCIATED WITH SEVERE POLYURIA AND HYPERCALCIURIA WITHOUT HYPERTENSION

    Fujita Megumi, Hirawa Nobuhito, Okuyama Yuki, Fujiwara Akira, Kobayashi Yusuke, Saka Sanae, Yatsu Keisuke, Nagahama Kiyotaka, Umemura Satoshi

    NEPHROLOGY   19   34 - 34   2014.5

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  • 非糖尿病患者における腎機能と起立時血圧変化の関連性、そのメカニズムとしての自律神経機能の関与の検討

    東 裕勝, 小林 雄祐, 藤川 哲也, 奥山 由紀, 藤田 恵美, 藤原 亮, 坂 早苗, 谷津 圭介, 平和 伸仁, 戸谷 義幸, 小林 英雄, 梅村 敏

    日本腎臓学会誌   56 ( 3 )   397 - 397   2014.5

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  • EFFECTS OF DOXAZOSIN AS THE THIRD AGENT ON MORNING HYPERTENSION IN DIABETIC PATIENTS WITH CHRONIC KIDNEY DISEASE

    Gen Yasuda, Sho Kinguchi, Mari Katsumata, Nobuhito Hirawa, Kazuhiko Shibata

    NEPHROLOGY DIALYSIS TRANSPLANTATION   29   61 - 61   2014.5

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  • SY5-4 Therapeutic experience of plasmapheresis with autoimmune bullous disease in our department(Apheresis for skin diseases-Present and future-,Symposium)

    Nakamura Kazuko, Matsukura Setsuko, Hirawa Nobuhito, Kambara Takeshi

    33   87 - 87   2014

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  • 高血圧遺伝子研究の最先端 ゲノムワイド解析による高血圧関連遺伝子ATP2B1の発見と遺伝子改変マウスを用いた機能解析

    平和 伸仁, 小林 雄祐, 藤原 亮, 藤田 恵美, 奥山 由紀, 勝又 真理, 坂 早苗, 山本 有一郎, 谷津 圭介, 戸谷 義幸, 安田 元, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   36回   251 - 251   2013.10

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  • 脂質異常症症例におけるCAVIを用いた動脈硬化の進展程度評価とその関連因子の検討

    富田 啓人, 小林 雄祐, 藤川 哲也, 新居田 翔子, 奥山 由紀, 鈴木 将太, 藤田 恵美, 藤原 亮, 坂 早苗, 谷津 圭介, 橋本 達夫, 平和 伸仁, 戸谷 義幸, 小林 英雄, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   36回   367 - 367   2013.10

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  • 起立性低血圧における動脈硬化指標CAVIと自律神経機能の関連の評価

    新居田 翔子, 小林 雄祐, 藤川 哲也, 小林 英雄, 富田 啓人, 奥山 由紀, 鈴木 将太, 藤田 恵美, 藤原 亮, 坂 早苗, 谷津 圭介, 橋本 達夫, 平和 伸仁, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   36回   301 - 301   2013.10

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  • ATP2B1遺伝子の全身ヘテロノックアウトマウスにおける血圧上昇とNO産生の低下

    藤原 亮, 平和 伸仁, 奥山 由紀, 藤田 恵美, 小林 雄祐, 谷津 圭介, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   36回   334 - 334   2013.10

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  • 高尿酸血症を有するCKD患者におけるフェブキソスタット/アロプリノールの効果 1年の無作為化比較試験

    平和 伸仁, 谷津 圭介, 勝又 真理, 松田 佳奈, 金口 翔, 奥山 由紀, 藤田 恵美, 藤原 亮, 山本 有一郎, 坂 早苗, 小林 雄祐, 戸谷 義幸, 安田 元, 梅村 敏

    日本腎臓学会誌   55 ( 6 )   1063 - 1063   2013.8

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  • 【血液透析患者の最適管理をめざして〜一般外来での対応】 血液透析患者の性機能・ホルモン異常

    小林 雄祐, 平和 伸仁

    診断と治療   101 ( 7 )   1065 - 1069   2013.7

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    Other Link: http://search.jamas.or.jp/link/ui/2013319251

  • 高血圧感受性遺伝子ATP2B1の機能 遠位尿細管特異的ATP2B1欠損マウスを用いた検討

    藤田 恵美, 平和 伸仁, 奥山 由紀, 藤原 亮, 坂 早苗, 小林 雄祐, 涌井 広道, 橋本 達夫, 長濱 清隆, 山本 有一郎, 谷津 圭介, 梅村 敏

    日本腎臓学会誌   55 ( 3 )   398 - 398   2013.4

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  • Plasmapheresis for the Treatment of Patients with Bullous Pemphigoid

    Ikezawa Yuko, Takahashi Kazuo, Morita Akiko, Kambara Takeshi, Hirawa Shinji, Aihara Michiko, Ikezawa Zenro

    32 ( 2 )   105 - 110   2013

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    Bullous pemphigoid (BP) is an autoimmune disease producing blisters at the subepidermal area with eosinophillic inflammation. Corticosteroid therapy is the first treatment of choice for patients with BP. Many BP patients are improved by a low to medium dose of steroid, but sometimes refractory to such treatment. However, high-dose systemic corticosteroid or immunosuppressant may cause severe side effects for aged BP patients. Plasmapheresis is also effective to reduce the dose of corticosteroid. It is important to start immediately combination therapy of apheresis in patients who are supposed to be resistant to steroid treatment.

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    Other Link: http://id.nii.ac.jp/1141/00151748/

  • ヒトゲノムワイド解析の成果を遺伝子改変動物を用いて証明・発展させる

    平和伸仁, 平和伸仁, 小林雄祐, 藤原亮, 藤田恵美, 奥山由紀, 坂早苗, 坂早苗, 谷津圭介, 梅村敏

    高血圧関連疾患モデル学会学術総会抄録集   49th   2013

  • 炎症性腸疾患に対する血球成分除去療法の行方 潰瘍性大腸炎に対する白血球系細胞除去療法の効果と予後関連因子に関する検討

    平和 伸仁, 山本 有一郎, 谷津 圭介, 坂 早苗, 勝又 真理, 江原 洋介, 藤原 亮, 藤田 恵美, 小林 雄祐, 宮崎 喜子, 大木 美樹, 戸谷 義幸, 安田 元, 梅村 敏

    日本アフェレシス学会雑誌   31 ( Suppl. )   75 - 75   2012.11

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  • ATP2B1遺伝子の全身ヘテロノックアウトマウスにおける血圧変化及びそのメカニズムの検討

    藤原亮, 平和伸仁, 藤田恵美, 宮崎喜子, 山本有一郎, 坂早苗, 一原直昭, 谷津圭介, 戸谷義幸, 安田元, 梅村敏

    日本高血圧学会総会プログラム・抄録集   35th   441   2012.9

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  • 新規高血圧感受性遺伝子ATP2B1は血管平滑筋において血圧調節と塩分感受性の重要な役割を担う

    小林雄祐, 平和伸仁, 藤田恵美, 宮崎喜子, 藤原亮, 山本有一郎, 坂早苗, 谷津圭介, 戸谷義幸, 安田元, 梅村敏

    日本高血圧学会総会プログラム・抄録集   35th   428 - 428   2012.9

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  • 急性腎障害(AKI)―概念の確認から,さらなる予後改善を目指して《AKIの診断》診断基準―RIFLE,AKIN,KDIGO分類の概要

    平和伸仁, 平和伸仁

    内科   110 ( 3 )   386 - 390   2012.9

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  • 診断基準 : RIFLE,AKIN,KDIGO分類の概要 (特集 急性腎障害(AKI) : 概念の確認から,さらなる予後改善を目指して) -- (AKIの診断)

    平和 伸仁

    内科   110 ( 3 )   386 - 390   2012.9

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  • 腎臓における高血圧感受性遺伝子ATP2B1の解析 遠位尿細管特異的Atp2b1欠損マウスを用いた検討

    藤田 恵美, 平和 伸仁, 藤原 亮, 宮崎 喜子, 坂 早苗, 小林 雄祐, 一原 直昭, 山本 有一郎, 谷津 圭介, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   35回   427 - 427   2012.9

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  • Sjogren症候群として観察中に腎障害が出現しIgG4関連腎臓病との鑑別を要した一症例

    奥真哉, 山本有一郎, 江原洋介, 勝又真理, 坂早苗, 谷津圭介, 平和伸仁, 梅村敏

    日本腎臓学会誌   54 ( 6 )   747   2012.8

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  • 慢性腎臓病患者に合併した急性膵炎の1症例

    古賀絵理, 平和伸仁, 勝又真理, 江原洋介, 山本有一郎, 坂早苗, 谷津圭介, 安田元, 梅村敏

    日本腎臓学会誌   54 ( 6 )   774   2012.8

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  • 高尿酸血症を有するCKD患者に対するフェブキソスタットとアロプリノールの効果 6ケ月の無作為比較試験

    平和伸仁, 谷津圭介, 山本有一郎, 坂早苗, 小林雄祐, 藤原亮, 藤田恵美, 江原洋介, 勝又真理, 小林麻裕美, 宮崎喜子, 戸谷義幸, 安田元, 梅村敏

    日本腎臓学会誌   54 ( 6 )   719 - 719   2012.8

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  • 強皮症腎クリーゼ患者に対し,腹膜透析を導入し救命し得た一症例

    菱川美紀, 平和伸仁, 勝又真理, 江原洋介, 山本有一郎, 坂早苗, 谷津圭介, 安田元, 梅村敏

    日本腎臓学会誌   54 ( 6 )   751   2012.8

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  • 頻回再発するネフローゼ症候群に木村病を合併した一例

    江原洋介, 平和伸仁, 勝又真理, 徳丸由佳, 山本有一郎, 坂早苗, 谷津圭介, 安田元, 梅村敏

    日本腎臓学会誌   54 ( 6 )   767   2012.8

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  • 深部静脈血栓症を契機に診断されたネフローゼ症候群の一例

    勝又真理, 平和伸仁, 江原洋介, 坂早苗, 山本有一郎, 谷津圭介, 安田元, 梅村敏

    日本腎臓学会誌   54 ( 6 )   768   2012.8

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  • Competitive inhibition of epinephrine on PTH-induced human renal camp accumulation and phosphate excretion

    G. Yasuda, K. Yatsu, N. Hirawa, S. Umemura

    BONE   50   S101 - S102   2012.5

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    DOI: 10.1016/j.bone.2012.02.307

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  • どんな症例にトルバプタンを使うべきか? 心不全治療におけるバソプレシンV2受容体拮抗薬の役割と期待

    猪又 孝元, 木田 圭亮, 平和 伸仁, 柴垣 有吾, 石上 友章, 鶴見 由起夫

    Pharma Medica   30 ( 5 )   202 - 209   2012.5

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  • 慢性腎臓病(CKD)に合併する高尿酸血症に対するフェブキソスタットとアロプリノールの比較

    平和 伸仁, 谷津 圭介, 山本 有一郎, 坂 早苗, 小林 雄祐, 藤原 亮, 藤田 恵美, 徳丸 由佳, 江原 洋介, 勝又 真理, 戸谷 義幸, 安田 元, 梅村 敏

    日本腎臓学会誌   54 ( 3 )   212 - 212   2012.4

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  • 末期腎不全患者の心不全症状に対してトルバプタンの併用を行い血液透析離脱が可能であった一例 (特集 心不全における体液貯留の新しい治療戦略 : 水利尿剤という新しいアプローチ) -- (症例呈示(病態編 : CKD合併の心不全症例))

    勝又 真理, 谷津 圭介, 平和 伸仁

    医薬ジャーナル   48 ( 2 )   729 - 732   2012.2

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  • 腎実質性高血圧における判断手順 (特集 腎性高血圧と動脈硬化)

    谷津 圭介, 平和 伸仁, 梅村 敏

    腎・高血圧の最新治療 = Current topics of kidney and hypertension : 腎・高血圧治療の今を伝える専門誌   1 ( 1 )   7 - 13   2012

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  • ゲノムワイド関連解析により同定された新規高血圧感受性遺伝子SMOC2の高感度酵母two-hybrid法による検討

    谷津 圭介, 江田 卓哉, 坂 早苗, 宮崎 喜子, 小林 雄祐, 藤原 亮, 藤田 恵美, 戸谷 義幸, 安田 元, 平和 伸仁, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   34回   566 - 566   2011.10

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  • ゲノムワイド関連解析より同定された新規高血圧感受性遺伝子LPIN1のノックアウトマウスを用いた検討

    藤田 恵美, 谷津 圭介, 坂 早苗, 宮崎 喜子, 小林 雄祐, 藤原 亮, 涌井 広道, 戸谷 義幸, 安田 元, 平和 伸仁, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   34回   565 - 565   2011.10

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  • ヒト内臓脂肪組織における新規高血圧感受性遺伝子LPIN1を含む、各種遺伝子発現の検討

    宮崎 喜子, 谷津 圭介, 坂 早苗, 小林 雄祐, 藤原 亮, 藤田 恵美, 涌井 広道, 戸谷 義幸, 安田 元, 平和 伸仁, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   34回   566 - 566   2011.10

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  • common diseaseに対しマイクロサテライトマーカーを用いたゲノムワイド関連解析の特徴

    谷津 圭介, 岡 晃, 坂 早苗, 宮崎 喜子, 小林 雄祐, 藤原 亮, 藤田 恵美, 平和 伸仁, 猪子 英俊, 梅村 敏

    日本内分泌学会雑誌   87 ( 2 )   782 - 782   2011.9

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  • β2-microglobulin吸着用カラム:リクセルS-15の長期使用における有効性及び安全性

    山本 有一郎, 平和 伸仁, 勝又 真理, 江原 洋介, 徳丸 由佳, 谷津 圭介, 安田 元, 梅村 敏, 大西 俊正

    日本アフェレシス学会雑誌   30 ( Suppl. )   163 - 163   2011.9

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  • IgA腎症感受性遺伝子のゲノムワイド探索から同定された候補遺伝子領域に対しepistasisの検討

    谷津 圭介, 坂 早苗, 岡 晃, 宮崎 喜子, 小林 雄祐, 藤原 亮, 藤田 恵美, 平和 伸仁, 猪子 英俊, 梅村 敏

    日本内分泌学会雑誌   87 ( 2 )   782 - 782   2011.9

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  • Effects of valsartan add-on treatment on aldosterone breakthrough in type 2 diabetic patients with hypertension receiving enalapril

    G. Yasuda, K. Yatsu, N. Hirawa, Y. Yamamoto

    DIABETOLOGIA   54   S443 - S444   2011.9

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  • Guidelines for the treatment of rapidly progressive glomerulonephritis, second version

    The Japanese journal of nephrology   53 ( 4 )   509 - 555   2011.5

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  • Effect of interaction between PTH and alpha-adrenoceptor agonist on human renal CAMP accumulation and phosphate excretion

    G. Yasuda, K. Yatsu, N. Hirawa, S. Umemura

    BONE   48   S146 - S146   2011.5

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    DOI: 10.1016/j.bone.2011.03.308

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  • Genomewide association studies for hypertension

    59 ( 1 )   45 - 50   2011.1

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  • Quitting Smoking and Professionalism.

    Hirawa Nobuhito

    Nihon Naika Gakkai Kaishi   99 ( 11 )   2876 - 2883   2010.11

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    DOI: 10.2169/naika.99.2876

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  • APJ受容体の心・血管外作用 マウス劇症肝炎モデルにおける検討

    安崎 弘晃, 吉田 伸一郎, 橋本 達夫, 一原 直昭, 小林 雄祐, 石田 純治, 田村 功一, 石上 友章, 平和 伸仁, 戸谷 義幸, 川名 一朗, 深水 昭吉, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   33回   315 - 315   2010.10

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  • 微小変化型ネフローゼ症候群(MCNS)初期治療におけるシクロスポリン併用療法の有用性の検討 シクロスポリン併用は治療中の血圧に影響を与えるか

    藤原 亮, 平和 伸仁, 藤田 恵美, 宮崎 喜子, 小林 雄祐, 小林 麻裕美, 山本 有一郎, 坂 早苗, 谷津 圭介, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   33回   397 - 397   2010.10

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  • 酸化ストレスによって発現を亢進させるAPJ受容体の機能・反応性と分子機序

    吉田 伸一郎, 橋本 達夫, 安崎 弘晃, 木原 実, 野村 幸一郎, 波多 のぞみ, 石田 純治, 一原 直昭, 小林 雄祐, 田村 功一, 石上 友章, 平和 伸仁, 戸谷 義幸, 深水 昭吉, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   33回   315 - 315   2010.10

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  • APJ受容体の動脈硬化増悪因子としての位置付け 酸化ストレス感受性分子としての重要性

    吉田 伸一郎, 橋本 達夫, 安崎 弘晃, 木原 実, 野村 幸一郎, 波多 のぞみ, 石田 純治, 一原 直昭, 小林 雄祐, 田村 功一, 石上 友章, 平和 伸仁, 戸谷 義幸, 深水 昭吉, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   33回   316 - 316   2010.10

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  • 新規高血圧感受性遺伝子ATP2B1の血管平滑筋特異的ノックアウトマウスを用いた検討

    小林 雄祐, 平和 伸仁, 藤田 恵美, 宮崎 喜子, 藤原 亮, 山本 有一郎, 坂 早苗, 吉田 伸一郎, 涌井 広道, 谷津 圭介, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   33回   250 - 250   2010.10

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  • EFFECTS OF QUINAPRIL ADD-ON TREATMENT ON ALDOSTERONE BREAKTHROUGH IN PATIENTS WITH ESSENTIAL HYPERTENSION RECEIVING VALSARTAN

    G. Yasuda, T. Iwamoto, K. Shibata, K. Yatsu, N. Hirawa, J. Yuto, S. Umemura

    JOURNAL OF HYPERTENSION   28   E386 - E386   2010.6

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  • IgA腎症感受性遺伝子TSPAN8の腎組織における発現解析

    比留川喬, WU Qiong, 坂早苗, 平和伸仁, 角田隆俊, 松阪泰二, 遠藤正之, 深川雅史, 猪子英俊, 梅村敏, 市川家國

    日本腎臓学会誌   52 ( 3 )   318   2010.5

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  • マイクロサテライト法によるIgA腎症感受性遺伝子のゲノムワイド探索

    坂早苗, 平和伸仁, 岡晃, 谷津圭介, 山本陵平, 松阪泰二, 今井圓裕, 成田一衛, 遠藤正之, 猪子英俊, 梅村敏, 市川家國

    日本腎臓学会誌   52 ( 3 )   302   2010.5

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  • Acute Kidney Injury (AKI) and Chronic Renal Failure.

    Fukagawa Masafumi, Suzuki Ayano, Haraguchi Kazutaka, Hirawa Nobuhito, Masakane Ikuto

    Nihon Naika Gakkai Kaishi   99 ( 5 )   1020 - 1040   2010.5

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    DOI: 10.2169/naika.99.1020

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  • マイクロサテライト法によるIgA腎症感受性遺伝子のゲノムワイド探索

    坂早苗, 平和伸仁, 谷津圭介, 梅村敏, 岡晃, 猪子英俊, 松阪泰二, 遠藤正之, 山本陵平, 今井圓裕, 成田一衛, 市川家國, 新村文男

    日本小児腎臓病学会雑誌   23 ( 1 )   74 - 75   2010.4

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  • 酸化ストレス感受性受容体APJを介したangiotensin IIの動脈硬化病変形成作用

    吉田 伸一郎, 橋本 達夫, 安崎 弘晃, 木原 実, 野村 幸一郎, 今井 のぞみ, 石田 純治, 一原 直昭, 小林 雄祐, 田村 功一, 石上 友章, 平和 伸仁, 戸谷 義幸, 深水 昭吉, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   32回   172 - 172   2009.10

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  • 慢性腎臓病患者の腎予後に対する無症候性脳梗塞の意義

    小林 麻裕美, 平和 伸仁, 谷津 圭介, 小林 雄祐, 山本 有一郎, 坂 早苗, 田村 功一, 戸谷 義幸, 安田 元, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   32回   201 - 201   2009.10

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  • 新ガイドラインで何が変わったか (新たな高血圧の治療戦略と患者管理--新ガイドラインの理解)

    平和 伸仁, 谷津 圭介, 梅村 敏

    看護技術   55 ( 10 )   1014 - 1021   2009.9

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  • International evidence of hypertensive treatment

    230 ( 5 )   420 - 429   2009.8

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  • Relationship between silent brain infarction and chronic kidney disease Reply

    Mayumi Kobayashi, Nobuhito Hirawa, Satoshi Umemura

    NEPHROLOGY DIALYSIS TRANSPLANTATION   24 ( 6 )   2005 - 2007   2009.6

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    DOI: 10.1093/ndt/gfp134

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  • ゲノムワイド相関解析により同定した新規候補遺伝子SMOC-2の血圧値に与える影響の検討(QTL解析)

    谷津 圭介, 平和 伸仁, 小林 雄祐, 小林 麻裕美, 坂 早苗, 安田 元, 岡 晃, 猪子 英俊, 涌井 広道, 一原 直昭, 戸谷 義幸, 梅村 敏

    日本腎臓学会誌   51 ( 3 )   349 - 349   2009.4

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  • 家族性に発症した慢性糸球体腎炎の一例

    涌井 広道, 岩坪 耕策, 三橋 洋, 金岡 知彦, 宮本 研, 池谷 裕子, 矢花 眞知子, 田村 功一, 平和 伸仁, 戸谷 義幸, 梅村 敏

    腎炎症例研究   25   106 - 119   2009.2

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  • Urinary Oxidative Stress Markers Closely Reflect the Efficacy of Candesartan Treatment for Diabetic Nephropathy

    Shin-ichiro Yoshida, Tatsuo Hashimoto, Minoru Kihara, Nozomi Imai, Hiroaki Yasuzaki, Kouichirou Nomura, Yoshihiro Kiuchi, Kouichi Tamura, Tomoaki Ishigami, Nobuhito Hirawa, Yoshiyuki Toya, Hitoshi Kitamura, Satoshi Umemura

    NEPHRON EXPERIMENTAL NEPHROLOGY   111 ( 1 )   E20 - E30   2009

  • 尿中リポカリン型プロスタグランジンD合成酵素は、2型糖尿病の腎障害を予測する。多施設前向き研究。

    平和 伸仁

    腎臓学・透析・移植   24 ( 2 )   8   2009

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  • 慢性腎臓病患者における無症候性脳虚血病変

    平和 伸仁

    腎臓病学・透析・移植   24 ( 1 )   7   2009

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  • 本態性高血圧新規候補遺伝子SMOC-2の高密度SNP関連解析 2万個のマイクロサテライトマーカーを用いたゲノムワイド相関解析の結果から

    谷津 圭介, 平和 伸仁, 岡 晃, 坂 早苗, 安藤 大作, 小林 麻由美, 安田 元, 涌井 広道, 小林 祐雄, 市原 直昭, 戸谷 義幸, 猪子 英俊, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   31回   183 - 183   2008.10

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  • 新規動脈硬化症増悪因子であるAPJ受容体の酸化ストレスによる発現制御

    吉田 伸一郎, 橋本 達夫, 木原 実, 野村 幸一郎, 安崎 弘晃, 今井 のぞみ, 宮本 研, 一原 直昭, 小林 雄祐, 田村 功一, 石上 友章, 平和 伸仁, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   31回   179 - 179   2008.10

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  • 【どうみる?どうケアする?透析患者症状別対応ガイド】 症状から患者の体の変化を探ってみよう! ショック

    平和 伸仁, 小林 雄祐, 坂 早苗, 安藤 大作

    透析ケア   14 ( 9 )   889 - 893   2008.9

  • Angiotensinogen gene polymorphism and blood pressure in large general population in Japan

    N. Hirawa, Y. Tabara, Y. Kita, T. Katsuya, T. Ohkubo, H. Rakugi, K. Obara, M. Ogawa, K. Yatsu, T. Shiwa, Y. Imai, H. Ueshima, T. Ogihara, T. Miki, S. Umemura

    JOURNAL OF HYPERTENSION   26   S133 - S133   2008.6

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  • Evaluation of orthostatic blood pressure changes in diabetic patients on hemodialysis using ambulatory blood pressure monitors equipped with a position-sensor

    G. Yasuda, N. Ogawa, S. Saka, M. Kobayashi, D. Ando, T. Kaneda, K. Yatsu, N. Hirawa, S. Umemura

    JOURNAL OF HYPERTENSION   26   S209 - S209   2008.6

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  • The hemodynamics and metabolisms of lipocalin-type prostaglandin D2 synthase in rat

    N. Hirawa, Y. Uehara, T. Tsuchida, Y. Kobayashi, M. Kobayashi, T. Kaneda, S. Saka, D. Andoh, K. Yatsu, K. Seiki, G. Yasuda, Y. Urade, S. Umemura

    JOURNAL OF HYPERTENSION   26   S432 - S432   2008.6

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  • The relationships among G protein alfa z polypeptide, fatty liver and blood pressure

    N. Hirawa, M. Ogawa, T. Shiwa, M. Kobayashi, Y. Kobayashi, Y. Yamamoto, S. Saka, D. Andoh, K. Yatsu, Y. Tabara, Y. Toya, G. Yasuda, T. Miki, S. Umemura

    JOURNAL OF HYPERTENSION   26   S229 - S229   2008.6

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  • The risk factors for carotid plaque formation and intimal-medial thickening in patients with chronic kidney disease

    S. Saka, N. Hirawa, M. Kobayashi, Y. Yamamoto, K. Yatsu, D. Andoh, Y. Toya, G. Yasuda, S. Umemura

    JOURNAL OF HYPERTENSION   26   S182 - S182   2008.6

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  • Association of fatty acid binding protein 3 gene variants with human essential hypertension

    T. Ueno, M. Soma, Y. Tabara, K. Tokunaga, K. Tahira, N. Fukuda, K. Matsumoto, Y. Nakayama, T. Katsuya, T. Ogihara, Y. Makita, A. Hata, M. Yamada, N. Takahashi, N. Hirawa, S. Umemura, T. Miki

    JOURNAL OF HYPERTENSION   26   S135 - S135   2008.6

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  • SNP association analysis on the results of the genome-wide association mapping using microsatellite markers for essential hypertension

    K. Yatsu, N. Hirawa, Y. Kobayashi, M. Kobayashi, S. Saka, H. Wakui, T. Eda, N. Ichihara, D. Ando, M. Ogawa, Y. Toya, G. Yasuda, A. Oka, H. Inoko, S. Umemura

    JOURNAL OF HYPERTENSION   26   S148 - S148   2008.6

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  • Effects of azelnidipine on ambulatory blood pressure and autonomic nervous activity in hemodialysis patients

    G. Yasuda, Y. Kobayashi, M. Kobayashi, T. Kaneda, Y. Yamamoto, S. Saka, D. Ando, K. Yatsu, N. Hirawa, S. Umemura

    NEPHROLOGY   13   A69 - A69   2008.5

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  • 維持腹膜透析患者の出口部感染にリネゾリド(ザイボツクス)が著効した一例

    金田 朋子, 安田 元, 安藤 大作, 平和 伸仁, 谷津 圭介, 小林 麻由美, 小林 雄祐, 戸谷 義幸, 梅村 敏

    日本透析医学会雑誌   41 ( Suppl.1 )   717 - 717   2008.5

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  • 透析日のみの不明熱を呈したリンパ節結核の一例

    安藤 大作, 安田 元, 小林 麻裕美, 金田 朋子, 小林 雄祐, 谷津 圭介, 平和 伸仁, 戸谷 義幸, 梅村 敏, 土橋 靖志, 大西 俊正

    日本透析医学会雑誌   41 ( Suppl.1 )   760 - 760   2008.5

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  • 血圧・呼吸の制御 慢性腎炎における血清アルブミン値の24時間血圧への影響

    安藤 大作, 安田 元, 小林 雄祐, 小林 麻裕美, 金田 朋子, 坂 早苗, 谷津 圭介, 平和 伸仁, 戸谷 義幸, 梅村 敏

    循環制御   29 ( Suppl. )   63 - 63   2008.5

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  • 初発の微小変化型ネフローゼ症候群の初期治療におけるシクロスポリン併用効果の検討

    小林 雄祐, 平和 伸仁, 金田 朋子, 小林 麻裕美, 山本 有一郎, 坂 早苗, 安藤 大作, 谷津 圭介, 戸谷 義幸, 安田 元, 梅村 敏

    日本腎臓学会誌   50 ( 3 )   347 - 347   2008.4

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  • 本態性高血圧症のQTL解析の結果と遺伝・環境因子相互作用の検討

    谷津 圭介, 平和 伸仁, 小林 雄祐, 金田 朋子, 小林 麻裕美, 坂 早苗, 安藤 大作, 安田 元, 岡 晃, 猪子 英俊, 涌井 広道, 戸谷 義幸, 梅村 敏

    日本腎臓学会誌   50 ( 3 )   336 - 336   2008.4

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  • Effects of quinapril add-on treatment on aldosterone escape in hypertensive patients with Type 2 diabetes receiving valsartan

    G. Yasuda, D. Ando, M. Kobayashi, S. Saka, K. Yatsu, Y. Yamamoto, N. Hirawa, S. Umemura

    DIABETES RESEARCH AND CLINICAL PRACTICE   79   S42 - S43   2008.3

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  • 脂肪酸結合蛋白3遺伝子変異は本態性高血圧と関連する

    平和 伸仁

    アメリカ高血圧雑誌   21 ( 6 )   5   2008

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  • 1.当院における白血球系細胞除去療法(LRT)の役割と安全性について(一般演題 : セッション2,日本アフェレシス学会第16回関東甲信越地方会抄録)

    平和 伸仁, 小林 祐介, 徳永 麻裕美, 山本 有一郎, 坂 早苗, 安藤 大作, 谷津 圭介, 遠藤 晃彦, 安田 元, 国崎 玲子, 小野 秀高, 木村 英明, 田中 克明

    日本アフェレシス学会雑誌   26 ( 3 )   364 - 364   2007.10

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  • 大規模日本人一般集団サンプルを用いた、Angiotensinogen遺伝子M235T多型と高血圧の関係

    平和 伸仁, 田原 康玄, 喜多 義邦, 勝谷 友宏, 大久保 孝義, 目時 弘仁, 菊谷 昌浩, 環 愼二, 中村 保幸, 杉本 研, 楽木 宏実, 小原 克彦, 小川 桃子, 谷津 圭介, 志和 忠志, 今井 潤, 上島 弘嗣, 荻原 俊男, 三木 哲郎, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   30回   244 - 244   2007.10

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  • 2万個のマイクロサテライトマーカーを用いたゲノムワイド相関解析の結果明らかとなった本態性高血圧新規候補遺伝子のSNP関連解析

    谷津 圭介, 平和 伸仁, 小林 雄祐, 小林 麻裕美, 金田 朋子, 坂 早苗, 安藤 大作, 安田 元, 岡 晃, 猪子 英俊, 水木 信久, 涌井 広道, 江田 卓哉, 小川 桃子, 志和 忠志, 戸谷 義幸, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   30回   221 - 221   2007.10

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  • IgA腎症疑いでフォローされていたが、腎生検でFabry病と診断された一例

    谷津 圭介, 平和 伸仁, 小林 雄祐, 小林 麻裕美, 金田 朋子, 坂 早苗, 安藤 大作, 安田 元, 戸谷 義幸, 梅村 敏

    日本腎臓学会誌   49 ( 6 )   600 - 600   2007.8

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  • 妊娠を契機にネフローゼ症候群およびSLEを発症し、治療に難渋した一例

    玉澤 彰英, 谷津 圭介, 小林 雄祐, 小林 麻裕美, 金田 朋子, 坂 早苗, 安藤 大作, 小川 幸, 斉藤 圭介, 高橋 恒男, 安田 元, 戸谷 義幸, 梅村 敏, 平和 伸仁

    日本腎臓学会誌   49 ( 6 )   626 - 626   2007.8

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  • 不明熱を呈した腹膜透析患者の一例

    安藤 大作, 平和 伸仁, 金田 朋子, 小林 雄祐, 徳永 麻裕美, 谷津 圭介, 戸谷 義幸, 村上 あゆみ, 野澤 昭典, 上, 安田 元, 梅村 敏

    日本腎臓学会誌   49 ( 6 )   630 - 630   2007.8

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  • 急速な臨床経過を呈した軽鎖沈着症の1例

    徳永 麻裕美, 平和 伸仁, 小林 雄祐, 金田 朋子, 安藤 大作, 谷津 圭介, 村上 あゆみ, 佐々木 毅, 野澤 昭典, 安田 元, 梅村 敏

    日本腎臓学会誌   49 ( 6 )   610 - 610   2007.8

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  • ステロイド治療および降圧治療により透析が回避された急速進行性糸球体腎炎(P-ANCA関連)の1症例

    坂 早苗, 平和 伸仁, 小林 雄祐, 金田 朋子, 小林 麻裕美, 山本 有一郎, 安藤 大作, 谷津 圭介, 遠藤 晃彦, 戸谷 義幸, 安田 元, 梅村 敏

    日本腎臓学会誌   49 ( 6 )   623 - 623   2007.8

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  • 臓器障害をほとんど認めない薬剤抵抗性の重症高血圧症の一例

    小林 雄祐, 平和 伸仁, 金田 朋子, 小林 麻裕美, 安藤 大作, 谷津 圭介, 宮島 栄治, 安田 元, 梅村 敏

    日本腎臓学会誌   49 ( 6 )   595 - 595   2007.8

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  • Effects of atorvastatin versus on low-density lipoprotein subtype distribution and renal function in hyperlipidemic patients with non-diabetic nephropathy

    G. Yasuda, K. Yatsu, D. Ando, S. Saka, T. Endo, N. Hirawa, S. Umemura

    ATHEROSCLEROSIS SUPPLEMENTS   8 ( 1 )   199 - 199   2007.6

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  • 低骨回転で低intactPTHの透析患者において、塩酸セベラマーは高リン血症を改善する

    平和 伸仁

    Therapeutic Aphereisis and Dialysis   11 ( 6 )   7   2007

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  • 高血圧関連遺伝子に対するマイクロサテライトマーカーを用いたゲノムワイド解析

    平和 伸仁

    高血圧   49 ( 3 )   7   2007

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  • The effects of leptin receptor gene polymorphism on visceral fat accumulation and blood pressure.

    Momoko Ogawa, Nobuhito Hirawa, Tadasi Shiwa, Teruhiko Endo, Masanari Umemura, Keisuke Yatsu, Sanae Saka, Kouichi Tamura, Tomoaki Ishigami, Gen Yasuda, Yoshiyuki Toya, Yasuharu Tabara, Tetsuro Miki, Katsuji Tokunaga, Satoshi Umemura

    JOURNAL OF HYPERTENSION   24   285 - 285   2006.12

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  • Loss of nocturnal decline of blood pressure in non-diabetic patients with nephrotic syndrome without renal dysfunction

    Daisaku Andou, Gen Yasuda, Sanae Saka, Nobuhito Hirawa, Teruhiko Endow, Keisuke Yatsu, Yuitirou Yamamoto, Mayumi Tokunaga, Satosi Umemura

    JOURNAL OF HYPERTENSION   24   148 - 148   2006.12

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  • Functional mutation of the 5 '-untranslated region of the follicle stimulating hormone receptor (FSHR) gene associated with female essential hypertension (EH)

    Tomohiro Nakayama, Nobuhiro Kuroi, Morihiko Sano, Yasuharu Tabara, Tomohiro Katsuya, Toshio Ogihara, Yoshio Makita, Akira Hata, Michiko Yamada, Norio Takahashi, Nobuhito Hirawa, Satoshi Umemura, Tetsuro Miki, Masayoshi Soma

    JOURNAL OF HYPERTENSION   24   335 - 335   2006.12

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  • The risk factors for intimal-medial thickening and plaque formation in hypertensive chronic kidney disease patients.

    Sanae Saka, Nobuhito Hirawa, Mayumi Tokunaga, Yuichiro Yamamoto, Keisuke Yatsu, Daisaku Ando, Teruhiko Endo, Tatsuo Hashimoto, Koichi Tamura, Yoshiyuki Toya, Gen Yasuda, Toshimasa Ohnishi, Satoshi Umemura

    JOURNAL OF HYPERTENSION   24   369 - 369   2006.12

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  • Urinary excretions of lipocalin-type prostaglandin D2 synthase predict the renal injury and proteinuria in oletf rats

    Nobuhito Hirawa, Momoko Ogawa, Takamasa Tsuchida, Kohsuke Seiki, Naomi Eguchis, Sanae Saka, Daisaku Andoh, Keisuke Yatsu, Teruhiko Endoh, Kouichi Tamura, Yoshiyuki Toya, Gen Yasuda, Yoshihiro Urade, Satoshi Umemura, Yoshio Uehara

    JOURNAL OF HYPERTENSION   24   224 - 224   2006.12

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  • Interacting molecule of angiotensin II type 1 (AT1) receptor, ATRAP, is co-localized with AT1 receptor in the mouse renal tubules

    Yuko Tsurumi, Kouichi Tamura, Yutaka Tanaka, Yuichi Koide, Masashi Sakai, Machiko Yabana, Yoshihiro Noda, Tatsuo Hashimoto, Minoru Kihara, Nobuhito Hirawa, Yoshiyuki Toya, Yoshihiro Kiuchi, Masaru Iwai, Masatsugu Horiuchi, Satoshi Umemura

    JOURNAL OF HYPERTENSION   24   298 - 298   2006.12

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  • Effects of probucol on low density lipoprotein subtype distribution and renal function in hyperlipidemic patients with non-diabetic nephropathy

    G. Yasuda, D. Ando, N. Hirawa, S. Saka, T. Endo, Y. Yamamoto, S. Umemura

    ATHEROSCLEROSIS SUPPLEMENTS   7 ( 3 )   575 - 575   2006.6

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  • 妊娠に合併したステロイド抵抗性の重症ネフローゼ症候群の1例

    田村 功一, 山内 淳司, 平和 伸仁, 河野 知之, 国保 敏晴, 戸谷 義幸, 常田 康夫, 矢花 眞知子, 大西 俊正, 稲山 嘉明, 長濱 清隆, 酒井 政司, 鶴見 裕子, 小澤 素子, 岩坪 耕策, 木原 実, 梅村 敏

    腎炎症例研究   22   107 - 122   2006.2

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    37歳女.上気道炎症があり,咳嗽が2週間持続,下肢に点状出血が出現し,紫斑といわれた.両下肢痛,浮腫が出現し,低蛋白血症と診断された.又,蛋白尿も出現した.妊娠が判明したため,アルブミン製剤の点滴静注を受けたが症状が改善せず,妊娠に合併したネフローゼ症候群治療のため入院した.尿蛋白3+,潜血3+,硝子/顆粒円柱を認め,眼瞼浮腫,眼瞼結膜貧血を認めた.両側下肺野に湿性ラ音を聴取したが,心音は正常であった.腎症状は紫斑後に出現し,血圧正常で,腎潜血陽性より紫斑病性腎炎の可能性が高いと診断した.ステロイドパルス療法,経口ステロイド療法を施行した.妊娠に合併した紫斑病性腎炎によるネフローゼ症候群と診断した.ステロイド療法に加え,シクロスポリンA(CyA),ARBテルミサルタンを併用投与し尿蛋白が減少した

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  • 内臓脂肪および血圧値に与えるレプチン受容体遺伝子多型の影響

    小川 桃子, 平和 伸仁, 志和 忠志

    横浜医学   57 ( 1 )   35 - 42   2006.1

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  • A possible relationship of nocturnal blood pressure variability with coronary artery disease in diabetic nephropathy

    K Tamura, J Yamauchi, Y Okano, Y Tsurumi, M Sakai, K Iwatsubo, T Shigenaga, M Ozawa, M Kihara, T Ishigami, N Hirawa, Y Toya, Y Tokita, T Ohnishi, S Umemura

    HYPERTENSION   46 ( 4 )   882 - 883   2005.10

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  • A novel regulatory effect of AT1 receptor-interacting molecule on cardiomyocytes

    K Tamura, Y Tanaka, Y Tsurumi, M Sakai, T Shigenaga, M Ozawa, K Iwatsubo, T Hashimoto, M Khara, T Ishigami, N Hirawa, Y Toya, M Horiuchi, S Umemura

    HYPERTENSION   46 ( 4 )   883 - 883   2005.10

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  • 2万個のマイクロサテライトマーカーを用い,本態性高血圧の疾患感受性(成因)遺伝子同定を目指したゲノムワイド相関解析

    谷津 圭介, 平和 伸仁, 小川 桃子, 志和 忠志, 相馬 正義, 羽田 明, 中尾 一和, 上島 弘嗣, 荻原 俊男, 友池 仁暢, 田原 康玄, 三木 哲郎, 木村 彰方, 岡 晃, 水木 信久, 猪子 英俊, 梅村 敏

    日本高血圧学会総会プログラム・抄録集   28回   29 - 29   2005.9

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  • インスリンシグナル増強因子3型(筋型)カベオリンの遺伝子導入は高脂肪食マウスのインスリン抵抗性を改善する

    戸谷 義幸, 大津 恒治, 押川 仁, 岩坪 耕策, 田村 功一, 平和 伸仁, 木原 実, 石上 友章, 萩原 康子, 南沢 享, 梅村 敏, 石川 義弘

    日本高血圧学会総会プログラム・抄録集   28回   35 - 35   2005.9

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  • THE CHARACTERISTICS OF LOW-DENSITY LIPOPROTEIN (LDL) PARTICLE SIZE IN HYPERCHOLESTEROLEMIC PATIENTS WITH CHRONIC GLOMERULONEPHRITIS

    Gen Yasuda, Shin-Ichiro Masuda, Nobuhito Hirawa, Daisaku Ando, Teruhiko Endo, Kyoko Dejima, Satoshi Umemura

    NEPHROLOGY   10   A273 - A273   2005.6

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  • Heparin recovers AT1 receptor and its intracellular signal transduction in cultured vascular smooth muscle cells (vol 579, pg 281, 2005)

    T Hashimoto, M Kihara, K Sato, N Imai, Y Tanaka, M Sakai, K Tamura, N Hirawa, Y Toya, H Kitamura, S Umemura

    FEBS LETTERS   579 ( 13 )   2972 - 2972   2005.5

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  • 血液透析患者における脳血管障害と遺伝子に関する検討

    藤川 哲也, 岩本 彩雄, 北村 文, 山口 聡, 小川 桃子, 遠藤 晃彦, 平和 伸仁, 梅村 敏, 池田 弓子

    日本腎臓学会誌   47 ( 3 )   328   2005.5

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  • Effects of losartan and amlodipine on macroalbuminuria and 24-H blood pressure in hypertensive type 2 diabetic patients with overt nephropathy

    G Yasuda, D Ando, S Masuda, N Hirawa, S Umemura, O Tochikubo

    AMERICAN JOURNAL OF HYPERTENSION   18 ( 5 )   138A - 139A   2005.5

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  • Mタンパク血症(IgG-kappa)を伴う悪性リンパ腫にネフローゼ症候群を呈した一例

    松下 啓, 長濱 清隆, 稲山 嘉明, 藤巻 克通, 遠藤 晃彦, 田村 功一, 平和 伸仁, 木原 実, 戸谷 義幸, 矢花 真知子, 梅村 敏

    腎炎症例研究   21   1 - 15   2005.2

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    46歳男.45歳で約3ヵ月前からの頸部腫脹が改善しないため来院,蛋白尿・顕微鏡的血尿を認め糸球体腎炎が疑われたが,頸部リンパ節生検にて悪性リンパ腫・M蛋白血症と診断された.更に4ヵ月後にはネフローゼ症候群を呈し,入院時検査所見では低蛋白血症・低アルブミン血症・高脂血症及び腎機能障害を認めた.悪性リンパ腫に伴う糸球体腎炎によるネフローゼ症候群と考え,プレドニゾロン(PSL)50mg/日の投与開始により症状は軽快して腎機能も改善した.第19病日に施行の経皮的腎生検により病理組織的にfibrillary glomerulonephritisと診断された.第29病日よりPSL40mg/日に減量し第38病日からはバルサルタン40mg/日を追加したところ蛋白尿も0.54g/日に減少したため第52病日退院となった.退院5ヵ月後にPSL10mg/日に減量したところ再びクレアチニン値や1日尿蛋白量が上昇したため20mg/日に増量して継続中である.退院8ヵ月後のCT所見では頸部・腋窩リンパ節の大きさに著変は認めていない

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  • The implication of urinary levels of prostaglandin D synthase in blood pressure variability

    N Hirawa, Y Okano, K Seiki, M Ogawa, A Endoh, K Yatsu, S Sakai, K Satoh, Y Tsurumi, K Tamura, T Ishigami, M Kihara, Y Toya, N Satoh, Y Urade, Y Uehara, S Umemura

    HYPERTENSION   44 ( 4 )   534 - 534   2004.10

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  • 何が正解?循環器治療 EBMで検証(13)造影剤と腎障害--そのメカニズムと予防方法について

    平和 伸仁, 増田 真一朗, 安藤 大作

    治療   86 ( 6 )   2003 - 2013   2004.6

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  • PE-444 Ex vivo E2F Decoy Therapy Preserves Endothelial Healing and Specifically Inhibits Smooth Muscle Cell Proliferation in Vein Grafts(Peripheral Circulation/Vascular Disease 4(H) : PE75)(Poster Session (English))

    Tamura Kouichi, Tanaka Yutaka, Koide Yuichi, Tsurumi Yuko, Sakai Masashi, Umemura Masanari, Hashimoto Tatsuo, Matsushita Kei, Hirawa Nobuhito, Ishigami Tomoaki, Kihara Minoru, Toya Yoshiyuki, Tokita Yasuo, Ehsan Afshin, Umemura Satoshi, Dzau Victor J.

    Circulation journal : official journal of the Japanese Circulation Society   68   470 - 470   2004.3

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  • 2 Molecular genetics of human hypertension-Role of Na handling along the renal tubules, the renin-angiotensin system and ubiquitinligase gene(Symposium 2 (SY2) (H) : Hypertension : From Molecular Mechanisms to Tailored Therapy)(Special Program)

    Ishigami Tomoaki, Lalouel Jean-Marc, Rohrwasser Andreas, Tamura Koichi, Hirawa Nobuhito, Yatsu Keisuke, Umemura Masanari, Uchino Kazuaki, Umemura Satoshi

    Circulation journal : official journal of the Japanese Circulation Society   68   31 - 31   2004.3

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  • The role of tissue kallikrein gene polymorphisms in essential hypertension

    N Hirawa, T Ishigami, M Ogawa, K Yatsu, Y Okano, S Sakai, S Ono, Y Tsurumi, T Endoh, K Matsushita, K Tamura, M Kihara, Y Toya, G Yasuda, S Umemura

    JOURNAL OF HYPERTENSION   22   S182 - S182   2004.2

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  • 何が正解? 循環器治療 EBMで検証 IgA腎症に対する薬物治療は?

    松下 啓, 戸谷 義幸, 木原 実, 平和 伸仁, 田村 功一, 遠藤 晃彦, 内野 和顕, 梅村 敏, 長濱 清隆

    治療   86 ( 2 )   379 - 386   2004.2

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  • 比較的短期間に下肢潰瘍と腎機能低下の増悪がみられ,コレステロール結晶塞栓症が疑われてLDL吸着療法および低用量ステロイド療法を施行して症状の改善が得られた一例

    田村 功一, 梅村 将就, 矢野 英人, 酒井 政司, 伊藤 陽子, 鶴見 裕子, 渋谷 研, 木村 寿宏, 小川 桃子, 横山 恵子, 岡野 泰子, 遠藤 晃彦, 松下 啓, 平和 伸仁, 木原 実, 矢花 眞知子, 戸谷 義幸, 臼井 孝, 常田 康夫, 梅村 敏

    腎炎症例研究   20   29 - 42   2004.2

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    68歳男.胸部圧迫感の精査として心臓カテーテル検査を行ったところ3ヵ月後に下肢潰瘍が出現し,腎機能低下を認めた.精査により糖尿病性腎症に合併したコレステロール結晶塞栓症と診断した.利尿薬とプロスタグランジンI2の投与を行ったが腎機能と炎症所見がさらに悪化した.LDL吸着療法を行ったところ皮膚症状は劇的に改善した.その後も腎機能障害やCRP高値が続くためプレドニゾロン20mg/日の投与を行い,改善が得られた

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  • Relationships between diurnal blood pressure variation, autonomic function and health-related QOL in hypertensive subjects

    Y Okano, N Hirawa, K Tamura, M Kihara, Y Toya, O Tochikubo, S Umemura

    JOURNAL OF HYPERTENSION   22   S190 - S191   2004.2

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  • Relationships between basal blood pressure, sympathetic nervous activity and health-related QOL in healthy adult

    Y Okano, N Hirawa, O Tochikubo, S Uemura

    JOURNAL OF HYPERTENSION   22   S119 - S119   2004.2

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  • Troglitazone treatment improves blood pressure, renal injury and urinary excretions of lipocalin-type prostaglandin D synthase in OLETF rats

    N Hirawa, Y Uehara, Y Kawabata, M Ogawa, R Taguchi, H Negoro, N Eguchi, N Nagata, T Tsuchida, K Seiki, N Satoh, T Endoh, K Matsushita, K Tamura, K Yatsu, M Kihara, Y Toya, Y Urade, S Umemura

    JOURNAL OF HYPERTENSION   22   S100 - S100   2004.2

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  • Urinary levels of prostaglandin D synthase as a determinant of blood pressure variability

    N Hirawa, Y Okano, K Seiki, H Oda, M Kihara, Y Toya, Y Uehara, S Umemura

    JOURNAL OF HYPERTENSION   20   S236 - S236   2002.6

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  • Serum and urinary levels of prostaglandin D synthase in essential hypertension

    N Hirawa, Y Uehara, M Yamakado, K Seiki, H Oda, Y Toya, S Umemura

    JOURNAL OF HYPERTENSION   20   S192 - S192   2002.6

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  • Blood sugar control reverses the increase in urinary excretion of prostaglandin D synthase in diabetic patients

    K Hamano, Y Totsuka, M Ajima, T Gomi, T Ikeda, N Hirawa, H Nakajima, H Oda, K Seiki, R Taguchi, Y Eguchi, Y Urada, Y Uehara

    JOURNAL OF HYPERTENSION   20   S361 - S361   2002.6

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  • Relationships between autonomic function and 24-hour blood pressure and health-related quality of life

    Y Okano, N Hirawa, O Tochikubo, S Mizushima, Y Suzukamo, S Fukuhara, S Umemura

    JOURNAL OF HYPERTENSION   20   S382 - S383   2002.6

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  • Prostaglandin D2 synthase in essential hypertension +/- m mu

    N Hirawa, Y Uehara, M Yamakado, K Seiki, H Oda, Y Urade, S Umemura

    HYPERTENSION   38 ( 3 )   525 - 525   2001.9

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  • 糖尿病の病初期より尿中プロスタグランジンD合成酵素(β-trace)排泄量が増加する

    平和 伸仁

    ネフロン   87/,321-327   2001

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  • Prostaglandin D-2 synthase in hypetensives with renal impairment

    N Hirawa, Y Uehara, T Gomi, T Ikeda, Y Urade, K Seiki, S Umemura

    JOURNAL OF HYPERTENSION   18   S104 - S104   2000

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  • The role of Y chromosome from Dahl salt-sensitive rats on development of salt-dependent hypertension

    Y Uehara, R Taguchi-Hakamada, Y Kawabata, N Hirawa, A Goto, M Omata

    JOURNAL OF HYPERTENSION   18   S125 - S125   2000

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  • Urinary prostaglandin D-2 synthase in hypertensives with diabetes mellitus

    N Hirawa, Y Uehara, T Gomi, T Ikeda, Y Urade, K Seiki, S Umemura

    JOURNAL OF HYPERTENSION   18   S139 - S139   2000

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  • 0274 Dahl食塩感受性高血圧Y染色体とインスリン感受性との関連性

    上原 誉志夫, 平和 伸仁, 川畑 ゆかり, 後藤 淳郎

    Japanese circulation journal   63 ( 1 )   216 - 216   1999.3

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  • レニン-アンジオテンシン系の抑制はダールラットの記憶能を改善させる.

    平和 伸仁

    (高血圧)   34/3,496-502 ( 3 )   7   1999

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  • ダール食塩感受性ラットにおけるカリクレイン持続注入による糸球体保護作用はブラジキニンB<sub>2</sub>受容体を介する作用である

    平和 伸仁

    (ネフロン)   81/2,183-93   1999

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  • 高食塩食は片側腎摘ラットにおける低濃度のangiotensin (]G0002[)に腎血管および糸球体障害を悪化させる.

    平和 伸仁

    (高血圧ジャーナル)   17/7,923-932   1999

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  • インスリン非依存性糖尿病の遺伝的モデルラットにおけるAngiotensin(]G0002[)受容体(1型)拮抗薬治療は、糖代謝に影響を与えず,血行動態および腎障害を改善させる.(共著)

    平和 伸仁

    アメリカ高血圧学会雑誌   12/1,21-7   1999

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  • Angiotensin II subtype-1 receptor antagonists improve hemodynamic and renal changes without affecting glucose metabolisms in genetic rat model of NIDDM

    Y Uehara, N Hirawa, Y Kawabata, A Numabe, A Goto, M Omata

    JOURNAL OF HYPERTENSION   16   S121 - S121   1998.6

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  • Troglitazone improves the blood pressure and the renal injuries seen in DAHL salt-sensitive rats

    N Hirawa, Y Uehara, N Ogawa, T Gomi, T Ikeda, A Goto, M Omata

    JOURNAL OF HYPERTENSION   16   S94 - S94   1998.6

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  • Chronic inhibition of renin-angiotensin system improves cerebral function in Dahl salt-sensitive rats

    N Hirawa, Y Uehara, N Ogawa, T Gomi, T Ikeda, T Ohnishi, M Omata

    JOURNAL OF HYPERTENSION   16   S114 - S114   1998.6

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  • P425 ダール食塩感受性ラットに対する長期低食塩食負荷 : レニン-アンジオテンシン系の抑制と臓器合併症

    平和 伸仁, 小川 成章, 大西 俊正, 上原 誉志夫, 後藤 淳郎, 小俣 政男, 五味 朋子, 池田 寿雄

    Japanese circulation journal   62 ( 0 )   491 - 491   1998.2

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  • 本態性高血圧患者において厳格な食塩制限は、交感神経活性を刺激することによりインスリン感受性を悪化させる(共著)

    平和 伸仁

    アメリカ高血圧学会雑誌   11/9,1048-55   1998

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  • High salt intake enhances the susceptibility to renal injury induced by non-pressor dose of angiotensin II

    N Hirawa, Y Uehara, T Gomi, T Ikeda, A Goto, M Omata

    HYPERTENSION   30 ( 3 )   P85 - P85   1997.9

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  • 0104 Dahl食塩感受性ラットに対するTroglitazoneの作用

    平和 伸仁, 小川 成章, 大西 俊正, 上原 誉志夫, 小俣 政夫, 五味 朋子, 池田 寿雄

    Japanese circulation journal   61 ( 0 )   137 - 137   1997.3

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  • Serum N-acetyl-β-D-glucosaminidase activity in a genetic rat model of non-insulin-dependent diabetes mellitus

    Yoshio Uehara, Nobuhito Hirawa, Yukari Kawabata, Atsushi Numabe, Hiroshi Nagoshi, Tomoko Gomi, Toshio Ikeda, Atsuo Goto, Teruhiko Toyo-oka, Masao Omata

    Hypertension Research   20 ( 3 )   193 - 199   1997

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    DOI: 10.1291/hypres.20.193

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  • 八味地黄丸はダール食塩感受性ラットの高血圧性腎障害保護作用を有する

    平和 伸仁

    アメリカ中国医学(漢方)学会雑誌   24/3-4,241-254   1996

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  • 0339 食塩感受性Dahl(DS)ラットの血圧および腎障害に対するカリクレイン-キニン系の役割

    平和 伸仁, 戸谷 義幸, 大西 俊正, 上原 誉志夫, 小俣 政男, 鈴木 友彦, 木付 和幸, 五味 朋子, 池田 寿雄

    Japanese circulation journal   59 ( 0 )   127 - 127   1995.3

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  • 非昇圧用量のアンジオテンシン(]G0002[)はダール食塩感受性ラットにおける高血圧性臓器障害を悪化させる

    平和 伸仁

    (高血圧ジャーナル)   13/1,81-90   1995

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  • ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR ENHANCES GENERATION OF NITRIC-OXIDE IN THE KIDNEY OF DAHL SALT-SENSITIVE RATS WITH HYPERTENSION

    N HIRAWA, Y UEHARA, Y KAWABATA, A NUMABE, T IKEDA

    CIRCULATION   90 ( 4 )   343 - 343   1994.10

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  • ADENOSINE A(1) RECEPTOR AND ITS GENE-EXPRESSION IN VENTRICLES FROM SPONTANEOUSLY HYPERTENSIVE RATS

    S KOBAYASHI, S UMEMURA, Y TOYA, N HIRAWA, S HAYASHI, TAKASAKI, I, K UCHINO, M ISHII

    HYPERTENSION   24 ( 3 )   388 - 388   1994.9

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  • 血管平滑筋細胞のストレス情報伝達における細胞内レニン・アンジオテンシン系の役割 : 第58回日本循環器学会学術集会

    上原 譽志夫, 沼部 敦司, 平和 伸仁, 後藤 淳郎, 小俣 政男

    Japanese circulation journal   58 ( 0 )   181 - 181   1994.3

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  • CORRELATION OF ALPHA-2-ADRENOCEPTOR GENE RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM (RFLP) WITH BLOOD-PRESSURE IN THE F2 RATS OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS (SHRSP)-WISTAR-KYOTO (WKY) RATS CROSS

    S KOBAYASHI, S UMEMURA, N HIRAWA, T IWAMOTO, S HAYASHI, TAKASAKI, I, M ISHII

    CIRCULATION   88 ( 4 )   383 - 383   1993.10

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  • IDENTIFICATION OFβ_2-ADRENOCEPTORADENYLATE CYCLASE(AC)SYSTEM IN HUMAN AORTIC ENDOTHELIAL CELLS(HAEC)

    IWAMOTO Tamio, UMEMURA Satoshi, TOYA Yoshiyuki, KIHARA Minoru, HIRAWA Nobuhito, KOBAYASHI Shun-ichi, TAKAGI Nobuyoshi, ISHII Masao

    Japanese circulation journal   57 ( 7 )   627 - 627   1993.7

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  • THE GENETIC ANALYSIS OF DAHLIWAI SALT-SENSITIVE RATS(S)AND SALT-RESISTANT RATS(R)USING DNA FINGERPRINTING

    YAMAGUCHI Satoshi, UMEMURA Satoshi, IWAMOTO Tamio, KOBAYASHI Shunichi, TAMURA Koiuichi, HIRAWA Nobuhito, TAKASAKI Izumi, ISHII Masao, IWAI Junichi

    Japanese circulation journal   57 ( 7 )   672 - 672   1993.7

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  • BENEFICIAL EFFECT OF ALPHA-BLOCKER ON HEMORHEOLOGY IN ESSENTIAL HYPERTENSIVES

    T GOMI, Y TAKAHASHI, Y TAKESHITA, J SAKURAI, N HIRAWA, T IKEDA

    HYPERTENSION   21 ( 4 )   577 - 577   1993.4

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  • INSULIN RESISTANCE CONTRIBUTES TO BLOOD-PRESSURE REGULATION IN ESSENTIAL HYPERTENSIVES WITH OBESITY

    J SAKURAI, Y TAKESHITA, N HIRAWA, Y TAKAHASHI, T GOMI, T IKEDA

    HYPERTENSION   21 ( 4 )   599 - 599   1993.4

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  • ASSOCIATION ANALYSIS OF RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM (RFLP) FOR THE ALPHA-ADRENOCEPTOR GENES IN ESSENTIAL-HYPERTENSION IN JAPAN

    S UMEMURA, N HIRAWA, T IWAMOTO, S YAMAGUCHI, Y TOYA, S KOBAYASHI, M KIHARA, TAKASAKI, I, G YASUDA, K TAMURA, M ISHII

    HYPERTENSION   21 ( 4 )   554 - 554   1993.4

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  • DIFFERENTIAL-EFFECTS ON RENAL INJURY BETWEEN ANGIOTENSIN-CONVERTING ENZYME-INHIBITION AND ANGIOTENSIN RECEPTOR ANTAGONISM IN DAHL RATS

    N HIRAWA, Y UEHARA, T NAGATA, M OMATA

    HYPERTENSION   21 ( 4 )   555 - 555   1993.4

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  • ダール食塩感受性ラットの血管障害に対するアンジオテンシン変換酵素阻害薬とアンジオテンシン受容体拮抗薬の作用の相違 : 口述発表 : 第57回日本循環器学会学術集会

    平和 伸仁, 五味 朋子, 池田 寿雄, 上原 誉志夫

    Japanese circulation journal   57 ( 0 )   134 - 134   1993.3

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  • Dahl-Iwai食塩感受性(S)および食塩抵抗性(R)ラット遺伝子のDNA fingerprintingを用いた検討 : ポスター発表 : 第57回日本循環器学会学術集会

    山口 聡, 梅村 敏, 岩本 彩雄, 小林 俊一, 田村 功一, 平和 伸仁, 高崎 泉, 石井 當男, Iwai Junichi

    Japanese circulation journal   57 ( 0 )   238 - 238   1993.3

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  • ヒト大動脈内皮細胞(HAEC)におけるβ_2受容体-adenylate cyclase系の証明 : 口述発表 : 第57回日本循環器学会学術集会

    岩本 彩雄, 梅村 敏, 戸谷 義幸, 木原 実, 平和 伸仁, 小林 俊一, 高木 信嘉, 石井 當男

    Japanese circulation journal   57 ( 0 )   130 - 130   1993.3

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  • Molecular biology of alpha-adrenergic receptor and essential hypertension

    S. Umemura, N. Hirawa, S. Kobayashi, T. Iwamoto, S. Yamaguchi, Y. Toya, K. Tamura, I. Takasaki, G. Yasuda

    Nippon rinsho. Japanese journal of clinical medicine   51 ( 6 )   1591 - 1601   1993

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  • OPC-13340, A NEW DIHYDROPYRIDINE CALCIUM-CHANNEL BLOCKER ATTENUATES RAPID VASCULAR SMOOTH-MUSCLE CELL-GROWTH IN SPONTANEOUSLY HYPERTENSIVE RATS

    Y UEHARA, Y KAWABATA, N HIRAWA, S TAKADA, A NUMABE, H MATSUOKA, T IKEDA, Y TAKABATAKE, S YAGI, T SUGIMOTO

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   20 ( 3 )   408 - 415   1992.9

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  • Dahl食塩感受性(S)ラットおよび食塩抵抗性(R)ラットにおけるα2受容体遺伝子制限酵素断片長多型(RFLP)の証明と, F2世代における分布について

    梅村 敏, 平和 伸仁, 安田 元, 石井 當男, W. A, P

    Japanese circulation journal   56 ( 0 )   394 - 394   1992.3

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  • RAPID SMOOTH-MUSCLE CELL-GROWTH AND ENDOGENOUS PROSTAGLANDIN SYSTEM IN SPONTANEOUSLY HYPERTENSIVE RATS

    Y UEHARA, A NUMABE, Y KAWABATA, T NAGATA, N HIRAWA, T ISHIMITSU, H MATSUOKA, T IKEDA, T SUGIMOTO

    AMERICAN JOURNAL OF HYPERTENSION   4 ( 10 )   806 - 814   1991.10

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  • ANTIHYPERTENSIVE EFFECTS OF CICLETANINE AND RENAL PROTECTION IN DAHL SALT-SENSITIVE RATS

    Y UEHARA, A NUMABE, N HIRAWA, Y KAWABATA, J IWAI, H ONO, H MATSUOKA, Y TAKABATAKE, S YAGI, T SUGIMOTO

    JOURNAL OF HYPERTENSION   9 ( 8 )   719 - 728   1991.8

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  • アテノロールは高血圧自然発症ラットの降圧系プロスタグランジン分泌を亢進させる

    平和 伸仁

    (クリニカル・サインエス)   81/4,499-507   1991

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  • 失神発作と労作性狭心症を伴った右冠動脈の左バルサルバ洞起始異常症の1例

    平和 伸仁, 小林 公也, 池田 弓子, 佐野 敏男, 吉村 浩, 木村 一雄, 杉本 孝一, 石川 利之, 久慈 直光, 石井 當男, 大村 延博

    Japanese circulation journal   54 ( 0 )   61 - 62   1990.12

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  • STIMULATING EFFECTS OF ATENOLOL ON VASODEPRESSOR PROSTAGLANDINS IN SPONTANEOUSLY HYPERTENSIVE RATS

    N HIRAWA, Y UEHARA, A NUMABE, S TAKADA, T NAGATA, S YAGI, M ISHII

    CIRCULATION   82 ( 4 )   15 - 15   1990.10

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  • RENIN GENE-EXPRESSION IN THE KIDNEY OF PATIENTS WITH PRIMARY ALDOSTERONISM

    H SHIONOIRI, N HIRAWA, S UEDA, K MINAMISAWA, T MATSUKAWA, E GOTOH, M ISHII, A FUKAMIZU, MS SEO, K MURAKAMI

    CIRCULATION   82 ( 4 )   553 - 553   1990.10

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  • -1286-CHRONOLOGICAL CHANGE OF α_1 -ADRENERGIC RECEPTOR BINDING SITES IN CARDIAC VENTRICLES FROM DAHL SALT-SENSITIVE RATS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY

    HAYASHI S, UMEMURA S, HIRAWA N, TOYA Y, SUGIMOTO K, ABE Y, TOKITA Y, NIHEI T, ISHII M, IWAI J

    Japanese circulation journal   54 ( 8 )   1086 - 1086   1990.8

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  • -0540-RELATIONSHIP BETWEEN HEMODYNAMICS AND 24-HR BLOOD PRESSURE PROFILES IN MILD ESSENTIAL HYPERTENSIVE PATIENTS : DEVELOPMENT OF A NEW NONINVASIVE DEVICE FOR MEASURING CARDIAC OUTPUT

    Tochikubo Osamu, Minamisawa Kohsuke, Miyajima Eiji, Kuji Naomitsu, Yoshida Yoko, Matsukawa Toshiyoshi, Yamada Yutaka, Hirawa Nobuhito, Ishii Masao

    Japanese circulation journal   54 ( 7 )   861 - 861   1990.7

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  • ALTERATIONS OF ARACHIDONATE METABOLISM AND ITS MECHANISMS IN VASCULAR SMOOTH MUSCLE CELLS OF DAHL SALT SENSITIVE RATS : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society

    Uehara Yoshio, Nagata Taiji, Hirawa Nobuhito, Matsuoka Hiroaki, Sugimoto Tsuneaki

    Japanese circulation journal   53 ( 8 )   987 - 987   1989.8

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  • -P106-IDENTIFICATION AND CHARACTERIZATION OF α2-ADRENOCEPTORS IN ISOLATED HUMAN GLOMERULI : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY

    Hirawa Nobuhito, Umemura Satoshi, Toya Yoshiyuki, Minamisawa Kohsuke, Hayashi Shuichi, Yasuda Gen, Takeda Kazuyoshi, Ishii Masao

    Japanese circulation journal   53 ( 6 )   669 - 669   1989.6

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  • -P105-LOCALIZATION OF ALPHA 1 AND ALPHA 2 ADRENOCEPTORS IN THE HUMAN KIDNEY : Hypertension : FREE COMMUNICATIONS(III) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY

    Minamisawa Kohsuke, Umemura Satoshi, Hirawa Nobuhito, Hayashi Shuuichi, Toya Yoshiyuki, Ishikawa Yoshihiro, Yasuda Gen, Ishii Masao

    Japanese circulation journal   53 ( 6 )   669 - 669   1989.6

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  • THE EFFECTS OF ALPHA 1-ADRENOCEPTOR AGONIST, PHENYLEPHRINE, ON PHOSPHOLIPASE-C IN VASCULAR SMOOTH-MUSCLE CELLS OF SPONTANEOUSLY HYPERTENSIVE RATS

    N HIRAWA, Y UEHARA, S TAKADA, A NUMABE, S YAGI

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   52 ( 9 )   1036 - 1036   1988.9

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  • THE EFFECTS OF AN ANGIOTENSIN CONVERTING ENZYME-INHIBITOR, CAPTOPRIL, ON VASCULAR PHOSPHOLIPASE-C ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS

    A NUMABE, Y UEHARA, S TAKADA, N HIRAWA, S YAGI

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   52 ( 9 )   911 - 912   1988.9

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  • HUMAN ATRIAL NATRIURETIC PEPTIDE INHIBITED CELLULAR CYCLIC-AMP LEVELS IN MICRODISSECTED HUMAN GLOMERULI

    Y TOYA, S UMEMURA, N HIRAWA, Y ISHIKAWA, G YASUDA, K MINAMIZAWA, S HAYASHI, M ISHII

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   52 ( 9 )   1046 - 1047   1988.9

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  • THE ROLES OF VASCULAR PROSTACYCLIN SYNTHASE IN DOCA-SALT HYPERTENSIVE RATS

    S TAKADA, Y UEHARA, A NUMABE, T ISHIMITSU, N HIRAWA, S YAGI

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   52 ( 9 )   969 - 969   1988.9

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  • ALPHA-2-ADRENOCEPTOR STIMULATION INHIBITED CELLULAR CYCLIC-AMP LEVELS IN MICRODISSECTED HUMAN GLOMERULI

    N HIRAWA, S UMEMURA, Y TOYA, K MINAMIZAWA, G YASUDA, Y ISHIKAWA, S HAYASHI, M ISHII

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   52 ( 9 )   973 - 973   1988.9

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Industrial property rights

  • 高血圧感受性遺伝子群の同定

    三木哲郎, 梅村敏, 平和伸仁

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    Application no:特願第2010-7018961  Date applied:2010.8

    Patent/Registration no:特許 韓国特許 10-1220806  Date issued:2013.1

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  • Identification of hypertension susceptibility gene group.

    HIRAWA Nobuhito

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    Application no:中国特許 ZL 200980114066.0  Date applied:2009.2

    Patent/Registration no:特許中国特許 1312261号  Date issued:2013.11

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  • 高血圧感受性遺伝子群の同定

    三木哲郎, 梅村敏, 平和伸仁

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    Application no:特願2008-040208  Date applied:2008.2

    Patent/Registration no:特許 第5608944号  Date issued:2014.9

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  • 高血圧の遺伝子マーカー

    三木哲郎, 梅村敏, 平和伸仁

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    Application no:特願2005-344267  Date applied:2005.11

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  • 高血圧感受性遺伝子群の同定

    三木哲郎, 梅村敏, 平和伸仁

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    Application no:特願欧州特許 J43287 A1 

    Patent/Registration no:特許ヨーロッパ特許 2256193  Date issued:2015.12

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  • 腎疾患の検出および病態管理方法

    織田浩司, 平和伸仁

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    Application no:特願特願平11-133050 

    Announcement no:特開特開2000-146980  Date announced:2000.5

    Patent/Registration no:特許第3961152号  Date issued:1999.5

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  • 高血圧感受性遺伝子群の同定

    平和 伸仁

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    Application no:特願2013-7010032 

    Patent/Registration no:特許韓国特許 第10-1458730  Date issued:2014.10

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Awards

  • President / President Award (Encouragement Award)

    2022.2   Yokohama City University  

    Department of Nephrology, Hypertension, Yokohama City, University Medical Center

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  • President Award

    2020.3   Yokoha City University  

    Nobuhito Hirawa

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  • Hospital Director Award

    2019.3   Yokohama City University Medical Center  

    Center for the Clinical Education and Residency Program

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  • ACPJC Contribution Award

    2018.6   American College of Physicians, Japan Chapter  

    Nobuhito HIRAWA

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  • Best Teacher Award

    2017.5   Yokohama City University School of Medicine  

    HIRAWA Nobuhito

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  • Chair's Award

    2016.3   Yokohama City University  

    HIRAWA Nobuhito

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  • Chair's Award

    2014.3   Yokohama City University  

    HIRAWA Nobuhito

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  • Best Instructor Award

    2006.12   Management committee of the junior residency program  

    HIRAWA Nobuhito

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  • 研究助成

    2001   木原記念横浜生命科学振興財団  

    平和 伸仁

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  • 研究奨励金

    1999   上原記念生命科学財団  

    平和 伸仁

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  • 横浜医学会 医学 研究奨励賞

    1997  

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    Country:Japan

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  • Young Investigator Travel Award: The 14th Scientific Meeting of the International Society of Hypertension

    1992  

    平和 伸仁

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  • Young Investigator Travel Award: The 13th Scientific Meeting of the International Society of Hypertension

    1990  

    平和 伸仁

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Research Projects

  • 高血圧関連遺伝子ATP2B1の腎機能および尿細管における意義に関する研究

    Grant number:19K08709  2019.4 - 2023.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    平和 伸仁, 藤原 亮, 坂 早苗

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    ATP2B1遺伝子は、ヒトミレニアムプロジェクトにより証明した、本態性高血圧の重要な候補遺伝子である。本遺伝子から、CaポンプであるPMCA1が作られ、細胞内(サイトゾル)のCaを汲み出すことにより、細胞内Ca濃度を調節している考えられている。我々は、Cre-loxpシステムを用いて、血管平滑筋においてATP2B1発現を抑制すると血管平滑筋細胞のCa濃度が上昇するとともに、血管収縮力が高まることを証明した。同マウスでは、Ca拮抗薬が効きやすいことは、そのメカニズムにCaチャネルが関係していることを示唆するが、一方で、血管収縮力が高まるというメカニズムだけで高血圧が生ずるかどうかについては、いまだに疑念が残るところである。血圧が上昇すれば、代償的に腎臓からのNa排泄が増加して、体液量を介した血圧低下作用などが生ずる可能性がある。また、腎臓、特に尿細管は、生態におけるCa代謝の中核的臓器である。尿細管におけるATP2B1の役割は、高血圧のみならず生理的な意味においても興味深いが、その意義はほとんど知られていない。
    そこで、我々は、本研究において、腎臓におけるATP2B1の役割を明らかにするために尿細管特異的なATP2B1KOマウスを作成し、その意義を解明することとした。ATP2B1 exon10をtargetとしてloxpで挟み込んだloxPマウスと遠位尿細管(~集合管)にCreを発現すKSP(cadherin16)マウスを用いて、 尿細管特異的ATP2B1ノックアウトマウスを作成した。本マウスでは、腎機能、血液生化学的検査に変化を認めなかった。尿生化学では、尿中Na排泄に差を認めなかったが、尿中Ca排泄が増加していた。さらに、KOマウスでは、尿量が有意に増加し、尿浸透圧が低下していた。そのメカニズムとして、AVPに対する反応性が低下していることが考えられた。

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  • Elucidation of the pathophysiology of hypertension with a focus on the LPIN1 gene.

    Grant number:19K08586  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    FUJIWARA AKIRA

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    We previously showed LPIN1 to be a candidate gene for essential hypertension by genome-wide association studies. However, little is known about the association between LPIN1 and blood pressure (BP). Therefore, we evaluated BP and mechanisms related BP in LPIN1-deficient [fatty liver dystrophy (fld)] mice. Fld mice had significantly elevated systolic BP and heart rate as measured by a radiotelemetric method. Fld mice showed elevated urinary catecholamine excretion and high BP response to clonidine (α2-adrenergic receptor agonist). The elevated BP in fld mice may result from activation of the sympathetic nervous system. These results indicate that LPIN1 plays a crucial role in blood pressure regulation and that LPIN1 is a new target gene for essential hypertension.

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  • 高血圧感受性遺伝子ATP2B1の血圧調節およびCa代謝に与える影響に関する研究

    2016.4 - 2019.3

    文部科学省:科研費 基盤研究(C) 

    平和 伸仁

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  • Elucidation of pathophysiology for development of new hypertension gene ATP2B1 and carotid atherosclerosis and development of treatment strategy

    Grant number:16K09477  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Yatsu Keisuke

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    We identified, a novel hypertension susceptibility gene, ATP2B1 by genome-wide association analysis. This gene encodes PMCA1, which excretes Ca2+ from cells. We created ATP2B1 vascular smooth muscle specific KO mice and whole body ATP2B1 hetero KO mice. We reported that Ca2+ dynamics and alteration of eNOS activity were involved in the mechanism of blood pressure elevation by ATP2B1 and that it is also involved in bone density and PTH secretion. In addition, it was suggested that ATP2B1 is involved in hypertension related renal disease.
    Furthermore, in order to investigate the direct relationship between ATP2B1 and atherosclerosis also in human, we have comprehensively analyzed potent ATP2B1 SNPs in people who measured the new atherosclerosis index CAVI.

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  • ゲノムワイド解析から同定した新規高血圧遺伝子:ATP2B1,LPIN1の機能解析

    2013.4 - 2016.3

    文部科学省  科研費 基盤研究(B) 

    梅村敏

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    Grant type:Competitive

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  • 高血圧感受性遺伝子ATP2B1の血圧および臓器障害に与える影響に関する研究

    2013.4 - 2016.3

    文部科学省  科研費 基盤研究(C) 

    平和 伸仁

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    Authorship:Principal investigator  Grant type:Competitive

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  • 新規に同定した3つの本態性高血圧の疾患感受性遺伝子の機能解析

    2008 - 2011

    文部科学省  科研費 基盤研究(B) 

    梅村 敏

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    Grant type:Competitive

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  • IgA nephropathy: the cause and the treatments

    2006

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    Grant type:Competitive

    We clarify the causative gene for IgA nephropathy using the genomewide microsatellite markers (by GWAS).

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  • IgA腎症の成因と治療に関する研究

    2006

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    Grant type:Competitive

    IgA腎症の遺伝的要因、治療を解明する。

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  • 腎臓病および腎不全発症に対する組織カリクレイン遺伝子の役割

    2002 - 2005

    文部科学省  科研費 基盤研究(C) 

    平和 伸仁

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    Authorship:Principal investigator  Grant type:Competitive

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  • 組織カリクレイン遺伝子多型と高血圧臓器障害における遺伝子解析の意義

    2000 - 2002

    文部科学省  科研費 奨励研究(A) 

    平和 伸仁

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    Authorship:Principal investigator  Grant type:Competitive

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  • The vascular complications of chronic kidney diesase

    1991

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    Grant type:Competitive

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  • 腎臓病における血管合併症

    1991

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    Grant type:Competitive

    腎機能の悪化と共に生ずる様々な病態を解明する。

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  • The mechanisms and the treatments of hypertension

    1987

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    Grant type:Competitive

    We attempt to clarify the genomic factors cousing essential hypertension.

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  • 高血圧の成因および治療に関する研究

    1987

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    Grant type:Competitive

    高血圧の成因として遺伝的要因を解明する。また、様々な治療法について開発、検討する。

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  • 食塩感受性高血圧の発症と治療に関する研究

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    Grant type:Competitive

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  • 高血圧および臓器障害に対するレニン・アンジオテンシン,カソクレイニーキニン系の役割

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    Grant type:Competitive

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  • 糖尿病性腎症の発症と予防に関する研究

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    Grant type:Competitive

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Teaching Experience

  • 教養ゼミ

    2018.4 - 2018.8 Institution:横浜市立大学

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  • 尿細管・間質性疾患

    Institution:横浜市立大学

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  • 高血圧学

    Institution:横浜市立大学

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  • 急性腎障害

    Institution:横浜市立大学

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  • 慢性腎臓病

    Institution:横浜市立大学

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