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写真a

フジサワ　シン
藤澤 信
Shin Fujisawa
所属
附属市民総合医療センター 血液内科 准教授
職名
准教授
ホームページ
http://www.yokohama-cu.ac.jp/urahp/section/blood/index.html
プロフィール
＜経歴＞1988年 東京医科大学 卒業
2003年5月～ 横浜市立大学附属市民総合医療センター 血液内科部長・准教授
＜研究分野＞血液造血器腫瘍に対する化学療法・造血幹細胞移植療法
＜資格＞医学博士
内科学会認定内科医・指導医
日本血液学会認定専門医・指導医・代議員
日本造血細胞移植学会認定医・評議員
日本臨床腫瘍学会暫定指導医
日本輸血細胞治療学会認定医
外部リンク

学位

  • 博士（医学）

研究キーワード

  • 血液腫瘍学

研究分野

  • ライフサイエンス / 血液、腫瘍内科学

論文

  • Survival impact of response within the first year in a multicenter prospective observational study of chronic GVHD in a Japanese cohort.

    Chikako Ohwada, Emiko Sakaida, Yusuke Takeda, Noriko Doki, Aiko Igarashi, Makoto Onizuka, Masako Toyosaki, Masatsugu Tanaka, Takayoshi Tachibana, Keisuke Kataoka, Jun Kato, Shin Fujisawa, Seiko Kato, Hideki Nakasone, Ken Naganuma, Takayuki Saitoh, Katsuhiro Shono, Maki Hagihara, Takeshi Saito, Kensuke Usuki, Takehiko Mori, Chiaki Nakaseko, Shinichiro Okamoto, Yoshinobu Kanda

    International journal of hematology   120 ( 3 )   347 - 355   2024年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A prospective multicenter observational study of organ response was conducted in patients with chronic GVHD diagnosed by the NIH criteria. When response was assessed at 12 months (12 M) in 118 patients, 74.6% were classified as responders and 25.4% as non-responders. The skin and oral cavity were the most frequent organs used as the basis for determining overall response. The lungs, liver, and eyes were also used in 20% of patients. Non-response decisions at 12 M were most frequent in the lungs. A significantly higher percentage of responders than non-responders completed systemic treatment (24.3% vs. 3.3%, P = 0.02). Global scoring showed significant changes, with improvement in responders and worsening in non-responders throughout the observation period. Two-year transplant-related mortality, using the 12 M assessment as the landmark, was significantly worse in non-responders (28.5% vs. 2,7%, P = 0.0001), while the 2-year recurrence rate was equivalent (5.4% vs. 4.8%, P = 0.78). Consequently, the 2-year overall survival rate from the 12 M assessment was significantly better in responders than non-responders (95% vs. 65.3%, P = 0.0001). Our data suggests that patients who do not achieve a response within the first year should be candidates for clinical studies on chronic GVHD.

    DOI： 10.1007/s12185-024-03813-0

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  • Utility of allogeneic stem cell transplantation for adult Ph+ALL with complete molecular remission. 国際誌

    Satoshi Nishiwaki, Isamu Sugiura, Shin Fujisawa, Yoshihiro Hatta, Yoshiko Atsuta, Noriko Doki, Shingo Kurahashi, Yasunori Ueda, Nobuaki Dobashi, Tomoya Maeda, Itaru Matsumura, Masatsugu Tanaka, Shinichi Kako, Tatsuo Ichinohe, Takahiro Fukuda, Shigeki Ohtake, Yuichi Ishikawa, Yasushi Miyazaki, Hitoshi Kiyoi

    American journal of hematology   99 ( 5 )   806 - 815   2024年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    This study aimed to investigate the usefulness of allogeneic stem cell transplantation (allo-SCT) for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) in the first complete remission (CR1) with complete molecular remission (CMR). We compared the outcomes between Ph+ALL patients who did or did not undergo allo-SCT in CR1. We included patients enrolled in the prospective clinical studies in the tyrosine kinase inhibitor era conducted by the Japan Adult Leukemia Study Group, who achieved CMR within 3 months. A total of 147 patients (allo-SCT: 101; non-SCT: 46) were eligible for this analysis. In the multivariate analyses, allo-SCT was significantly associated with both superior overall survival (OS) (adjusted hazard ratio (aHR): 0.54; 95% CI: 0.30-0.97; p = .04) and relapse-free survival (RFS) (aHR: 0.21; 95% CI: 0.12-0.38; p < .001). The 5-year adjusted OS and RFS were 73% and 70% in the allo-SCT cohort, whereas they were 50% and 20% in the non-SCT cohort. Despite the higher non-relapse mortality (aHR: 3.49; 95% CI: 1.17-10.4; p = .03), allo-SCT was significantly associated with a lower relapse rate (aHR: 0.10; 95% CI: 0.05-0.20; p < .001). In addition, allo-SCT was also associated with superior graft-versus-host disease-free, relapse-free survival (aHR: 0.43; 95% CI: 0.25-0.74; p = .002). Propensity score-matched analyses confirmed the results of the multivariate analyses. In patients who achieved CMR within 3 months, allo-SCT in CR1 had superior survival and lower relapse compared with the non-SCT cohort.

    DOI： 10.1002/ajh.27237

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  • Investigation of biomarkers to predict outcomes in allogeneic hematopoietic stem cell transplantation. 国際誌

    Takayoshi Tachibana, Takuya Miyazaki, Ayako Matsumura, Maki Hagihara, Masatsugu Tanaka, Satoshi Koyama, Eriko Ogusa, Jun Aoki, Yuki Nakajima, Hiroyuki Takahashi, Taisei Suzuki, Yoshimi Ishii, Haruka Teshigawara, Kenji Matsumoto, Mayumi Hatayama, Akihiko Izumi, Katsuya Ikuta, Koji Yamamoto, Heiwa Kanamori, Shin Fujisawa, Hideaki Nakajima

    Cytotherapy   2024年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Various biomarkers have been developed and evaluated to predict the prognosis and complications of allogeneic hematopoietic cell transplantation (HCT). Most previous studies conducted on different biomarkers evaluated single effects such as those associated with inflammation, immunology, iron metabolism, and nutrition, and only a few studies have comprehensively analyzed markers. OBJECTIVE: The study aimed to survey comprehensive multiple markers prior to HCT and extract those that significantly predict the outcomes. STUDY DESIGN: A prospective multicenter observational study was performed. (UMIN000013506) Patients undergoing HCT for hematologic diseases were consecutively enrolled. Besides the usual clinical biomarkers, serum samples for extra-clinical biomarkers were collected and cryopreserved before starting the conditioning regimen. A total of 32 candidate biomarkers were selected, 23 from hematology, biochemistry, immunology, nutrition, and iron metabolism, and 9 from composite markers. Based on the area under the curve (AUC) values for survival, promising biomarkers was extracted. Internal validation for these markers was applied based on bootstrap methods. Setting the cut-off values for them, log-rank test was applied and outcomes including overall survival (OS), relapse, and non-relapse mortality (NRM) were evaluated using multivariate analyses. Furthermore, detailed analysis including transplant-related complications and external validation were conducted focusing on C-reactive protein (CRP) to platelet (Plt) ratio. RESULTS: A total of 152 patients with hematologic malignancies were enrolled from April 2014 to March 2017. CRP, soluble interleukin-2 receptor (IL2R), CRP to albumin (Alb) ratio, CRP to Plt ratio, Plt to IL2R ratio, and IL2R to Alb ratio were identified as promising markers. Internal validation successfully confirmed their reliability of AUC and multivariate analysis demonstrated the statistical significance between the higher and the lower markers. Above all, a higher CRP to Plt ratio was significantly associated with a lower OS (hazard ratio [HR] 2.77; 95% confidence interval [CI] 1.30-5.91; P = 0.008) and higher non-relapse mortality rates (HR 2.79; 95%CI 1.14-6.80; P = 0.024) at 180 days. Furthermore, univariate analysis showed that a higher CRP to Plt ratio was significantly associated with a higher incidence of sinusoidal obstructive syndrome (P < 0.001) and bloodstream infection (P = 0.027). An external validation test confirmed the significance of the CRP to Plt ratio for these outcomes. CONCLUSION: The multicenter prospective observational study successfully identified significant biomarkers in patients with hematologic malignancies who received HCT. In particular, CRP to Plt ratio was identified as a novel and useful biomarker for predicting transplant outcomes. Further investigations are needed to validate the novel markers, analysis of the pathophysiology, and application to treatment settings other than HCT.

    DOI： 10.1016/j.jcyt.2024.03.490

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  • Comparison of standardized prophylactic high-dose and intrathecal methotrexate for DLBCL with a high risk of CNS relapse

    Masahiro Akimoto, Takuya Miyazaki, Hiroyuki Takahashi, Yusuke Saigusa, Takaaki Takeda, Yuto Hibino, Mayumi Tokunaga, Takuma Ohashi, Ayako Matsumura, Haruka Teshigawara, Taisei Suzuki, Hiroshi Teranaka, Yuki Nakajima, Kenji Matsumoto, Chizuko Hashimoto, Katsumichi Fujimaki, Hiroyuki Fujita, Rika Sakai, Shin Fujisawa, Hideaki Nakajima

    International Journal of Hematology   119 ( 2 )   164 - 172   2024年1月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

    DOI： 10.1007/s12185-023-03700-0

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    その他リンク： https://link.springer.com/article/10.1007/s12185-023-03700-0/fulltext.html

  • Clinical significance of total nucleated cell count in bone marrow of patients with acute lymphoblastic leukemia who underwent allogeneic hematopoietic stem cell transplantation.

    Jun Nukui, Takayoshi Tachibana, Takuya Miyazaki, Masatsugu Tanaka, Kenji Matsumoto, Yoshimi Ishii, Ayumi Numata, Yuki Nakajima, Ayako Matsumura, Taisei Suzuki, Akihiko Izumi, Natsuki Hirose, Koji Yamamoto, Maki Hagihara, Shin Fujisawa, Heiwa Kanamori, Hideaki Nakajima

    International journal of hematology   119 ( 1 )   62 - 70   2024年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The clinical implications of recipient bone marrow nucleated cell count (NCC) prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain unknown. We conducted a multicenter retrospective study to evaluate the clinical significance of bone marrow NCC prior to allo-HSCT in patients with acute lymphoblastic leukemia. Patients who were in remission and underwent the initial allo-HSCT were included and stratified into high- and low-NCC groups using an NCC of 10 × 104/µL as the cut-off. The 3-year overall survival (OS), non-relapse mortality (NRM), and relapse rates for the high- and low-NCC groups were 51.2 vs. 84.5% (p < 0.001), 27.5 vs. 6.5% (p < 0.001), and 31.1 vs. 24.4% (p = 0.322), respectively. The high-NCC group had significantly poorer OS and higher NRM when compared with the low-NCC group. In summary, high recipient bone marrow NCC is associated with higher NRM and lower OS following allo-HSCT.

    DOI： 10.1007/s12185-023-03688-7

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  • Clinical significance of late CMV disease in adult patients who underwent allogeneic stem cell transplant. 国際誌

    Hiroaki Shimizu, Yuho Najima, Shinichi Kako, Masatsugu Tanaka, Shin-Ichiro Fujiwara, Takehiko Mori, Kensuke Usuki, Moritaka Gotoh, Maki Hagihara, Nobuhiro Tsukada, Makoto Oniduka, Satoru Takada, Emiko Sakaida, Shin Fujisawa, Masahiro Onoda, Nobuyuki Aotsuka, Shingo Yano, Kazuteru Ohashi, Satoshi Takahashi, Shinichiro Okamoto, Yoshinobu Kanda

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2023年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    INTRODUCTION: Late cytomegalovirus (CMV) disease, which was defined as CMV disease occurring >100 days post-transplant, remains an important complication among allogeneic stem cell transplant recipients, even now that the prophylactic strategy using ganciclovir preemptive therapy has been established. Due to the recent expansion of donor sources and conditioning regimens, it is therefore appropriate to reevaluate the incidence, risk factors, and clinical impacts of late CMV disease. METHODS: This study included the 1295 adult patients, who underwent transplant for the first time from 2008 to 2015, without underlying disease relapse or CMV disease within 100 days post-transplant. There were no restrictions on underlying diseases or transplant procedures. RESULTS: During the median follow-up period of 48.4 months, 21 patients developed late CMV disease and the 5-year cumulative incidence of late CMV disease was 1.6%. By multivariate analysis, haploidentical related donor, adult T-cell leukemia lymphoma, and preemptive therapy before 100 days post-transplant were extracted as independent risk factors. Late CMV disease negatively affected transplant outcomes, and was identified as an independent risk factor for the non-relapse mortality rate (hazard ratio 3.83, p < 0.001) and overall survival rate (hazard ratio 4.01, p < 0.001). Although 17 of 21 patients with late CMV disease died, the main causes of death were not related to CMV, except in three patients with CMV pneumonia. CONCLUSIONS: Although the incidence of late CMV disease is low in transplant recipients, this complication negatively affects clinical courses. Therefore, transplant recipients with these risk factors should be more carefully managed.

    DOI： 10.1016/j.jiac.2023.07.015

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  • High-risk Combinations of Additional Chromosomal Abnormalities in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia: JALSG Ph+ALL TKI-SCT Study. 国際誌

    Satoshi Nishiwaki, Isamu Sugiura, Shin Fujisawa, Yoshihiro Hatta, Yoshiko Atsuta, Noriko Doki, Shingo Kurahashi, Yasunori Ueda, Nobuaki Dobashi, Tomoya Maeda, Yasuhiro Taniguchi, Masatsugu Tanaka, Shinichi Kako, Tatsuo Ichinohe, Takahiro Fukuda, Shigeki Ohtake, Yuichi Ishikawa, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki

    HemaSphere   7 ( 6 )   e899   2023年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1097/HS9.0000000000000899

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  • Clinical risk factors for patients with myelodysplastic syndromes undergoing allogeneic hematopoietic stem cell transplantation

    Haruka Teshigawara-Tanabe, Maki Hagihara, Jun Aoki, Satoshi Koyama, Hiroyuki Takahashi, Yuki Nakajima, Hiroyoshi Kunimoto, Takayoshi Tachibana, Takuya Miyazaki, Kenji Matsumoto, Masatsugu Tanaka, Etsuko Yamazaki, Shin Fujisawa, Heiwa Kanamori, Masataka Taguri, Hideaki Nakajima

    Hematology   27 ( 1 )   620 - 628   2022年12月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Informa UK Limited  

    DOI： 10.1080/16078454.2022.2052601

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  • Clinical impact of cigarette smoking on the outcomes of allogeneic hematopoietic stem cell transplantation: a multicenter retrospective study. 国際誌

    Takuma Ohashi, Jun Aoki, Taiki Ando, Yasufumi Ishiyama, Yoshimi Ishii, Kazuho Miyashita, Yuki Nakajima, Takayoshi Tachibana, Maki Hagihara, Kenji Matsumoto, Masatsugu Tanaka, Heiwa Kanamori, Shin Fujisawa, Hideaki Nakajima

    Bone marrow transplantation   57 ( 7 )   1124 - 1132   2022年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Smoking is associated with a high risk for different diseases including respiratory tract infections in immunocompetent patients. However, data about the effects of cigarette smoking on the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are limited. Therefore, we retrospectively investigated 608 patients aged ≥20 years with hematological disorders who received their first allo-HSCT at our group of hospitals between 2000 and 2015, and evaluated the impact of cigarette smoking before allo-HSCT on clinical outcomes by dividing patients into two groups according to the Brinkman index (BI) (nonsmokers or light smokers [BI: 0-500] and heavy smokers [BI: ≥ 500]). Multivariate analyses showed that heavy smoking was associated with a high 5-year cumulative incidence of chronic graft-versus-host disease (cGVHD) (hazard ratio [HR]: 1.73, 95% confidence interval [CI]: 1.15-2.61, p < 0.01). The 5-year overall survival (HR: 1.16, 95% CI: 0.86-1.58, p = 0.33) and disease-free survival (HR: 1.12, 95% CI: 0.83-1.52, p = 0.45) were similar between the two groups. Hence, cigarette smoking is correlated with cGVHD, although prospective studies must be conducted to further verify this result.

    DOI： 10.1038/s41409-022-01678-7

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  • Pre-conditioning intervention in patients with relapsed or refractory acute lymphoblastic leukemia who underwent allogeneic hematopoietic cell transplantation: a KSGCT multicenter retrospective analysis. 国際誌

    Takayoshi Tachibana, Junya Kanda, Takuma Ishizaki, Yuho Najima, Masatsugu Tanaka, Noriko Doki, Shin-Ichiro Fujiwara, Shun-Ichi Kimura, Makoto Onizuka, Satoshi Takahashi, Takeshi Saito, Takehiko Mori, Shin Fujisawa, Emiko Sakaida, Takuya Miyazaki, Nobuyuki Aotsuka, Moritaka Gotoh, Reiko Watanabe, Katsuhiro Shono, Heiwa Kanamori, Yoshinobu Kanda, Shinichiro Okamoto

    Annals of hematology   100 ( 11 )   2763 - 2771   2021年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The efficacy and clinical significance of pre-conditioning intervention (PCI) before allogeneic hematopoietic cell transplantation (HCT) in patients with acute lymphoblastic leukemia (ALL) not in remission remain inconclusive. The purpose of this multicenter retrospective study was to clarify the clinical significance of PCI before HCT in patients with non-remission ALL. Patients with non-remission ALL who received HCT between 2005 and 2015 at 16 institutions were included. PCI was objectively defined and classified to three groups according to the intensity of PCI (no, intensive, or moderate). The study cohort consisted of 104 patients with a median age of 38 (range 17-68). A significant decrease of blast percentage in the peripheral blood (PB) was confirmed in both PCI groups, suggesting that PCIs were effective to stabilize the disease activity. The group with moderate PCI had higher nucleated cell count in the BM compared to the group with intensive PCI or the group without PCI. The overall survival (OS) rates of groups with intensive and no PCI showed comparable and significantly better compared to the group with moderate PCI (P = 0.009). Multivariate analysis demonstrated that the OS of moderate PCI group was significantly worse compared to that of intensive PCI group (HR = 2.43, 95% CI: 1.32-4.14, P = 0.004), while the OS of intensive PCI group was comparable to that of the group without PCI. These results suggest that the intensity of PCI rather than the response to PCI may contribute to improve the transplant outcome in patients with ALL not in remission.

    DOI： 10.1007/s00277-021-04607-8

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  • Compromised anti-tumor-immune features of myeloid cell components in chronic myeloid leukemia patients. 国際誌

    Ibuki Harada, Haruka Sasaki, Koichi Murakami, Akira Nishiyama, Jun Nakabayashi, Motohide Ichino, Takuya Miyazaki, Ken Kumagai, Kenji Matsumoto, Maki Hagihara, Wataru Kawase, Takayoshi Tachibana, Masatsugu Tanaka, Tomoyuki Saito, Heiwa Kanamori, Hiroyuki Fujita, Shin Fujisawa, Hideaki Nakajima, Tomohiko Tamura

    Scientific reports   11 ( 1 )   18046 - 18046   2021年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Chronic myeloid leukemia (CML) is a form of myeloproliferative neoplasm caused by the oncogenic tyrosine kinase BCR-ABL. Although tyrosine kinase inhibitors have dramatically improved the prognosis of patients with CML, several problems such as resistance and recurrence still exist. Immunological control may contribute to solving these problems, and it is important to understand why CML patients fail to spontaneously develop anti-tumor immunity. Here, we show that differentiation of conventional dendritic cells (cDCs), which are vital for anti-tumor immunity, is restricted from an early stage of hematopoiesis in CML. In addition, we found that monocytes and basophils, which are increased in CML patients, express high levels of PD-L1, an immune checkpoint molecule that inhibits T cell responses. Moreover, RNA-sequencing analysis revealed that basophils express genes related to poor prognosis in CML. Our data suggest that BCR-ABL not only disrupts the "accelerator" (i.e., cDCs) but also applies the "brake" (i.e., monocytes and basophils) of anti-tumor immunity, compromising the defense against CML cells.

    DOI： 10.1038/s41598-021-97371-8

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  • Novel Indicators of Transplant Outcomes for PhALL: Current Molecular-Relapse-Free Survival. 国際誌

    Hideki Nakasone, Shinichi Kako, Takayoshi Tachibana, Masatsugu Tanaka, Makoto Onizuka, Satoshi Takahashi, Akira Yokota, Shin-Ichiro Fujiwara, Toru Sakura, Emiko Sakaida, Shin Fujisawa, Rie Yamazaki, Moritaka Gotoh, Maki Hagihara, Nobuyuki Aotsuka, Nobuhiro Tsukada, Yoshihiro Hatta, Hiroaki Shimizu, Kensuke Usuki, Reiko Watanabe, Takehiko Mori, Shingo Yano, Heiwa Kanamori, Yoshinobu Kanda

    Transplantation and cellular therapy   27 ( 9 )   800.e1-800.e8   2021年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Molecular relapse after allogeneic hematopoietic cell transplantation (allo-HCT) has been thought to predict clinical relapse in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (PhALL). Tyrosine kinase inhibitor (TKI) administration after allo-HCT may dynamically change the status from molecular relapse to molecular remission, but these state changes cannot be accurately represented by conventional survival indicators such as relapse-free survival, where events are usually considered irreversible. We aimed to develop novel indicators of transplant outcomes for allo-HCT recipients with PhALL and to visualize current molecular-relapse-free survival (CMRFS) and current on-TKI status (CTKI), treating molecular relapse or TKI administration after allo-HCT as a reversible event. We retrospectively analyzed 286 patients with PhALL who received allo-HCT between 2000 and 2016 in order to develop the indicators. CMRFS was defined as the probability of molecular remission without clinical relapse or death at any time after allo-HCT. Similarly, CTKI was defined as the probability of TKI administration without clinical relapse or death at any time after allo-HCT. The 1- and 5-year CMRFS rates were 67% and 59%, respectively, whereas the 1- and 5-year conventional molecular relapse-free survival rates were 42% and 37%. The 1- and 5-year CTKI rates were 14% and 8%, respectively. In a post hoc analysis focusing on patients who had achieved a molecular complete remission within 6 weeks (n = 201), the 5-year CMRFS rate (71%) was similar to the 5-year conventional molecular relapse-free survival (molRFS) rate (70%) in the non-TKI group. On the other hand, the 5-year CMRFS rate in the TKI group was 61%, whereas the 5-year conventional molRFS rate was only 38%. CMRFS and CTKI might become useful indicators of transplant success in terms of survival, leukemia-free status, and treatment-free status at any time point. Future extension of these survival models to other clinical situations is warranted.

    DOI： 10.1016/j.jtct.2021.06.020

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  • Minimal residual disease (MRD) positivity at allogeneic hematopoietic cell transplantation, not the quantity of MRD, is a risk factor for relapse of Philadelphia chromosome-positive acute lymphoblastic leukemia.

    Yu Akahoshi, Yasuyuki Arai, Satoshi Nishiwaki, Shuichi Mizuta, Atsushi Marumo, Naoyuki Uchida, Yoshinobu Kanda, Hitoshi Sakai, Satoru Takada, Takahiro Fukuda, Shin Fujisawa, Takashi Ashida, Junji Tanaka, Yoshiko Atsuta, Shinichi Kako

    International journal of hematology   113 ( 6 )   832 - 839   2021年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Minimal residual disease (MRD) monitoring by quantitative real-time reverse transcription PCR (qRT-PCR) is the standard of care in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL). We evaluated the impact of MRD status at hematopoietic cell transplantation (HCT) on relapse, as measured by a unified protocol at a central laboratory. Only patients with Ph-positive ALL who had minor transcripts (e1a2) and who underwent allogeneic HCT in first complete remission between 2008 and 2017 were included. First, patients with negative-MRD (n = 196) and positive-MRD (n = 61) at HCT were analyzed. As expected, MRD positivity at HCT was significantly associated with an increased risk of hematological relapse (hazard ratio [HR], 2.91; 95% CI 1.67-5.08; P < 0.001) in the multivariate analysis. Next, patients with positive-MRD were divided into low-MRD (n = 39) and high-MRD (n = 22) groups. In the multivariate analysis, high-MRD at HCT was not significantly associated with an increased risk of hematological relapse compared to the low-MRD group (HR 1.10; 95% CI 0.54-2.83; P = 0.620). These results indicate that the therapeutic decisions should be made based on MRD positivity, rather than on the MRD level, at HCT.

    DOI： 10.1007/s12185-021-03094-x

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  • Stopping tyrosine kinase inhibitors started after allogeneic HCT in patients with Philadelphia chromosome-positive leukemia. 国際誌

    Hideki Nakasone, Shinichi Kako, Takehiko Mori, Satoshi Takahashi, Makoto Onizuka, Shin-Ichiro Fujiwara, Toru Sakura, Emiko Sakaida, Akira Yokota, Nobuyuki Aotsuka, Maki Hagihara, Nobuhiro Tsukada, Yoshihiro Hatta, Kensuke Usuki, Reiko Watanabe, Moritaka Gotoh, Shin Fujisawa, Shingo Yano, Heiwa Kanamori, Shinichiro Okamoto, Yoshinobu Kanda

    Bone marrow transplantation   56 ( 6 )   1402 - 1412   2021年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    For patients with Philadelphia chromosome (Ph)-positive leukemia, there is no consensus regarding how long tyrosine kinase inhibitors (TKI) should be given or whether TKI could be stopped if TKI is administrated after allogeneic hematopoietic cell transplantation (allo-HCT). We analyzed relapse-free survival (RFS) in 92 allo-HCT patients who received TKI for >3 months after allo-HCT, and aimed to develop a novel indicator, called as current TKI- & relapse-free (cTRFree) achievement. TKI after allo-HCT was started as planned in 39 patients, based on measurable residual disease (MRD) in 53 at a median of 152 days after allo-HCT. There was no difference in post-TKI RFS between the planned and MRD-based starting groups (P = 0.69). Second-generation TKIs were associated with superior RFS in Ph-positive acute leukemia (HR 2.71, P = 0.031). TKI was stopped before relapse in 48 patients. Stopping TKI as a time-dependent covariate was not associated with subsequent hematological relapse (HR 1.18, P = 0.72). In the TKI-stop group, TKI administration for >6 months tended to be associated with superior RFS (HR = 0.30, P = 0.08). As an indicator of transplant success, cTRFree was 35% 5 years after starting TKI. TKI could be stopped for recipients with sustained undetectable MRD. However, further prospective studies will be required to establish clinical recommendations.

    DOI： 10.1038/s41409-020-01206-5

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  • Clinical Benefits of Preconditioning Intervention in Patients with Relapsed or Refractory Acute Myelogenous Leukemia Who Underwent Allogeneic Hematopoietic Cell Transplantation: A Kanto Study of Group for Cell Therapy Multicenter Analysis. 国際誌

    Takayoshi Tachibana, Junya Kanda, Takuma Ishizaki, Yuho Najima, Masatsugu Tanaka, Noriko Doki, Shin-Ichiro Fujiwara, Shun-Ichi Kimura, Makoto Onizuka, Satoshi Takahashi, Takeshi Saito, Takehiko Mori, Shin Fujisawa, Emiko Sakaida, Takuya Miyazaki, Nobuyuki Aotsuka, Moritaka Gotoh, Reiko Watanabe, Katsuhiro Shono, Kensuke Usuki, Nobuhiro Tsukada, Heiwa Kanamori, Yoshinobu Kanda, Shinichiro Okamoto

    Transplantation and cellular therapy   27 ( 1 )   70.e1-70.e8   2021年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A multicenter retrospective study was conducted to evaluate the clinical significance of preconditioning intervention (PCI) before allogeneic hematopoietic cell transplantation (HCT) in patients with acute myelogenous leukemia (AML) not in remission. The study cohort consisted of 519 patients classified according to the intensity (intensive/moderate) of PCI and their response to PCI. The group treated with PCI had higher blast counts in the peripheral blood (PB) and had a lower overall survival (OS) rate (P < .001) and higher nonrelapse mortality (NRM) rate (P = .035) compared with those without PCI (no PCI group). Approximately 40% of the patients (68 of 236) achieved a good response to PCI (good PCI group), and those patients had lower blast counts in the PB compared with the group with poor response to PCI (poor PCI group). OS in the good PCI group was comparable to that in the no PCI group and significantly better than that in the poor PCI group (hazard ratio, .54; 95% confidence interval, .39 to .77; P < .001). However, OS was significantly lower in patients with intensive/moderate PCI compared with the no PCI group. These results suggest that PCI increases NRM without decreasing the post-transplantation relapse rate, but may be beneficial for patients with lower blast counts in PB irrespective of its intensity.

    DOI： 10.1016/j.bbmt.2020.09.025

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  • Computed tomography-defined sarcopenia: prognostic predictor of nonrelapse mortality after allogeneic hematopoietic stem cell transplantation: a multicenter retrospective study.

    Taiki Ando, Shin Fujisawa, Haruka Teshigawara, Ayako Matsumura, Takayuki Sakuma, Taisei Suzuki, Hiroshi Teranaka, Eriko Ogusa, Yoshimi Ishii, Kazuho Miyashita, Hiroyuki Takahashi, Yuki Nakajima, Takuya Miyazaki, Maki Hagihara, Kenji Matsumoto, Etsuko Yamazaki, Hideaki Nakajima

    International journal of hematology   112 ( 1 )   46 - 56   2020年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    We analyzed clinical cutoffs for defining computed tomography (CT) methods for sarcopenia and examined the prognostic value of CT for allogeneic hematopoietic stem cell transplantation (allo-HCST) outcomes of patients with myeloid malignancy. One hundred twenty-five adult patients with acute myeloid leukemia and myelodysplastic syndrome who underwent first allo-HSCT between 2000 and 2017 were included. Sarcopenia was assessed using CT-based skeletal muscle index (SMI) and mean muscle attenuation at L3. A statistical difference in SMI was confirmed between sarcopenia (n = 52) and nonsarcopenia (n = 73) patients. There were no significant correlations of muscularity with age, performance status, or other characteristics of HSCT. After 2 years, overall survival (OS) was 43.5% and 70.1%, disease-free survival was 52.9% and 68.6%, nonrelapse mortality (NRM) was 20.8% and 8.4%, incidence of acute GVHD (≥ grade 2) was 38.8% and 39.1%, that of chronic GVHD was 53.2% and 37.3%, and median duration of hospitalization was 88 days and 74 days (P = 0.026), respectively, in the sarcopenia and nonsarcopenia groups. Multivariate analysis showed that presence of sarcopenia is a novel adverse factor for high NRM and poor OS. Pretransplant CT-defined sarcopenia is correlated with decreased OS, increased NRM, and prolonged hospitalization.

    DOI： 10.1007/s12185-020-02870-5

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  • Outcomes and Prognostic Factors for Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia Who Underwent Allogeneic Hematopoietic Cell Transplantation: A KSGCT Multicenter Analysis. 査読 国際誌

    Takayoshi Tachibana, Junya Kanda, Takuma Ishizaki, Yuho Najima, Masatsugu Tanaka, Noriko Doki, Shin-Ichiro Fujiwara, Shun-Ichi Kimura, Makoto Onizuka, Satoshi Takahashi, Takeshi Saito, Takehiko Mori, Shin Fujisawa, Emiko Sakaida, Kenji Matsumoto, Nobuyuki Aotsuka, Moritaka Gotoh, Reiko Watanabe, Katsuhiro Shono, Kensuke Usuki, Nobuhiro Tsukada, Heiwa Kanamori, Yoshinobu Kanda, Shinichiro Okamoto

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   26 ( 5 )   998 - 1004   2020年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A multicenter retrospective study was performed to evaluate the prognostic factors in 104 patients with relapsed or refractory acute lymphoblastic leukemia (ALL), who underwent allogeneic hematopoietic cell transplantation (HCT) between 2005 and 2015. The median age was 38 (range, 17 to 68), and the median blast fraction in peripheral blood and bone marrow was 1% (range, 0 to 99%) and 52% (range, 0 to 100%), respectively. With a median follow-up of 47 months (range, 8.3 to 105 months), overall survival (OS), nonrelapse mortality, and relapse mortality at 1 year were 25%, 44%, and 31%, respectively. Multivariate analysis demonstrated independent predictors for poor OS, including nuclear cell count in the bone marrow ≥10 × 104/μL (hazard ratio [HR], 2.14; 95% confidence interval [CI], 1.33 to 3.43; P = .002), elevated lactate dehydrogenase level (HR, 1.66; 95% CI, 1.05 to 2.62; P = .031), and no primary induction failure (HR, 2.05; 95% CI, 1.11 to 3.78; P = .022). A prognostic scoring index was designed based on these survival predictors. At 2 years, OS was 28%, 14%, and 0% for good (score 0 or 1; n = 47), intermediate (score 2; n = 40), and poor (score 3; n = 17), respectively (P < .001). This scoring system may be useful in identifying the patient population for which allogeneic HCT is least beneficial in advanced stages of ALL.

    DOI： 10.1016/j.bbmt.2020.01.007

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  • Hematopoietic Stem Cell Transplantation From a Related Donor with Human Leukocyte Antigen 1-Antigen Mismatch in the Graft-Versus-Host Direction Using Low-dose Anti-thymocyte Globulin

    Junya Kanda, Toshihiko Ando, Shun-ichi Kimura, Shin-ichiro Fujiwara, Kazunori Imada, Shin Fujisawa, Takayoshi Tachibana, Yoshiko Atsuta, Yoshinobu Kanda

    Cell Transplantation   2020年1月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1177/0963689720976567

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  • A Prospective, Longitudinal Observation of the Incidence, Treatment, and Survival of Late Acute and Chronic Graft-versus-Host Disease by National Institutes of Health Criteria in a Japanese Cohort. 国際誌

    Chikako Ohwada, Emiko Sakaida, Aiko Igarashi, Takeshi Kobayashi, Noriko Doki, Takehiko Mori, Jun Kato, Yuya Koda, Heiwa Kanamori, Masatsugu Tanaka, Takayoshi Tachibana, Shin Fujisawa, Yuki Nakajima, Ayumi Numata, Masako Toyosaki, Yasuyuki Aoyama, Makoto Onizuka, Maki Hagihara, Satoshi Koyama, Yoshinobu Kanda, Hideki Nakasone, Hiroaki Shimizu, Seiko Kato, Reiko Watanabe, Katsuhiro Shono, Rika Sakai, Takeshi Saito, Chiaki Nakaseko, Shinichiro Okamoto

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   26 ( 1 )   162 - 170   2020年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    To prospectively validate the incidence, manifestations, and outcomes of graft-versus-host disease (GVHD) by National Institutes of Health criteria, we recruited 406 hematopoietic stem cell transplantation recipients at 16 transplant centers in Japan from May 2012 to June 2014. The 2-year cumulative incidence of late acute and chronic GVHD was 3.2% (n = 13) and 35.4% (n = 145), with a median onset of 3.6 and 4.7 months after transplant, respectively. The global severity at onset was mild in 30.3%, moderate in 43.5%, and severe in 26.2%. Eighty-two patients were followed up for 2 years, with 79.3% still manifesting GVHD symptoms, and 80.6% (n = 117) of the patients received systemic immunosuppressive treatment (IST), with a 2-year cumulative incidence of IST termination of 33.1%. Severe patients showed a significantly lower rate of IST termination than those with mild and moderate severities (mild, 38.5%; moderate, 40.9%; and severe, 17.2%). The 2-year incidence of nonrelapse mortality (NRM) and relapse was not significantly different according to the severity at onset (NRM: mild [16.6%] versus moderate [8.7%] versus severe [16.1%]; relapse: mild [14.9%] versus moderate [14.7%] versus severe [5.3%]). As a result, 2-year overall survival (OS) and GVHD-specific survival (GSS) were equivalent according to the severity at onset (mild: OS = 81.0%, GSS = 85.7%; moderate: OS = 84.2%, GSS = 92.5%; severe: OS = 83.9%, GSS = 89.2%). Our study helped identify the characteristics of late acute and chronic GVHD in Japanese patients. Further investigation is needed to identify an optimal endpoint for survival prediction.

    DOI： 10.1016/j.bbmt.2019.09.016

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  • Prognostic impact of cytogenetic abnormalities in adult patients with Philadelphia chromosome-negative ALL who underwent an allogeneic transplant. 査読 国際誌

    Hiroaki Shimizu, Noriko Doki, Heiwa Kanamori, Toru Sakura, Takehiko Mori, Shinichiro Machida, Satoshi Takahashi, Chikako Ohwada, Shin Fujisawa, Shingo Yano, Maki Hagihara, Yoshinobu Kanda, Masahiro Onoda, Moritaka Gotoh, Shinichi Kako, Jun Taguchi, Kensuke Usuki, Nobutaka Kawai, Nobuyuki Aotsuka, Shinichiro Okamoto

    Bone marrow transplantation   54 ( 12 )   2020 - 2026   2019年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Although cytogenetic abnormalities at diagnosis are recognized as an important prognostic factor in patients with Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL), the prognostic impact has not been evaluated in allogeneic stem cell transplant (allo-SCT) recipients. Thus, we assessed 373 Ph-negative ALL patients who underwent allo-SCT. The high-risk (HR) group included those with t(4;11), t(8;14), low hypodiploidy, and complex karyotype, and the standard risk (SR) group included all other karyotypes. Among the 204 patients who underwent a transplant during the first remission (167 in the SR group and 37 in the HR group), the overall survival (OS) rates were similar between these groups (64.1% vs. 80.0% at 5 years, respectively; p = 0.12). Conversely, among the 106 patients who underwent a transplant while not in remission (84 in the SR group and 22 in the HR group), patients in the SR group showed a significantly superior OS rate compared to the HR group (15.4% vs. 4.5% at 5 years, respectively; p = 0.022). These results suggested that treatment outcomes of Ph-negative ALL patients with HR cytogenetic abnormalities may improve following allo-SCT, especially in the first remission. Innovative transplant approaches are warranted in patients who are not in remission.

    DOI： 10.1038/s41409-019-0585-2

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  • Allogeneic hematopoietic cell transplantation in patients with untreated acute myeloid leukemia: a KSGCT multicenter retrospective analysis. 査読 国際誌

    Tachibana T, Ishizaki T, Takahashi S, Najima Y, Kimura SI, Sakaida E, Onizuka M, Mori T, Fujisawa S, Fujiwara SI, Saito T, Hagihara M, Aotsuka N, Gotoh M, Usuki K, Tsukada N, Kanda J, Kanamori H, Kanda Y, Okamoto S, Kanto Study, Group for Cell Therapy, KSGCT

    Bone marrow transplantation   55 ( 7 )   1497 - 1501   2019年9月

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  • Predictive values of early suppression of tumorigenicity 2 for acute GVHD and transplant-related complications after allogeneic stem cell transplantation: prospective observational study

    Ayako Matsumura, Takuya Miyazaki, Takayoshi Tachibana, Taiki Ando, Megumi Koyama, Satoshi Koyama, Yoshimi Ishii, Hiroyuki Takahashi, Yuki Nakajima, Ayumi Numata, Wataru Yamamoto, Kenji Motohashi, Maki Hagihara, Kenji Matsumoto, Shin Fujisawa, Hideaki Nakajima

    Turkish Journal of Hematology   2019年8月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Galenos Yayinevi  

    DOI： 10.4274/tjh.galenos.2019.2019.0139

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  • Efficacy and safety of oral deferasirox treatment for transfusional iron overload in pure red cell aplasia patients after allogeneic stem cell transplantation. 査読 国際誌

    Ryo Shimizu, Masahiro Takeuchi, Emiko Sakaida, Chikako Ohwada, Masako Toyosaki, Shinichiro Machida, Makoto Onizuka, Katsuhiro Shono, Masahiro Onoda, Takeshi Saito, Shingo Yano, Masatsugu Tanaka, Shin Fujisawa, Takehiko Mori, Kensuke Usuki, Satoshi Takahashi, Heiwa Kanamori, Chiaki Nakaseko, Shinichiro Okamoto

    Annals of hematology   98 ( 7 )   1781 - 1783   2019年7月

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  • Impact of treatment-related weight changes from diagnosis to hematopoietic stem-cell transplantation on clinical outcome of acute myeloid leukemia.

    Taiki Ando, Shin Fujisawa, Haruka Teshigawara, Eriko Ogusa, Yoshimi Ishii, Kazuho Miyashita, Kenji Motohashi, Takuya Miyazaki, Takayoshi Tachibana, Maki Hagihara, Kenji Matsumoto, Masatsugu Tanaka, Chizuko Hashimoto, Hideyuki Koharazawa, Katsumichi Fujimaki, Jun Taguchi, Hiroyuki Fujita, Heiwa Kanamori, Etsuko Yamazaki, Hideaki Nakajima

    International journal of hematology   109 ( 6 )   673 - 683   2019年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    We hypothesized that treatment-related weight loss is associated with worse outcomes following HSCT. Overall, 184 patients with AML who underwent induction therapy were classified according to d-BMI (BMI at transplant minus BMI at diagnosis) (kg/m2) as < -2, - 2 to + 2, and > + 2. At 1 year, OS was 67.9% (95% CI, 60.7-74.2), DFS was 64.1% (95% CI, 56.7-70.6), and GRFS was 40.2% (95% CI, 33.1-47.2). For d-BMI groups < - 2, - 2 to + 2, and > + 2, GRFS at 1 year was 16.1% (95% CI, 5.1-31.4), 45.4% (95% CI, 36.4-53.7), and 41.7% (95% CI, 22.2-60.1), respectively (P = 0.0067). Multivariate analysis showed that both worse OS (HR, 1.78; 95% CI, 1.02-3.14; P = 0.007) and GRFS (HR, 2.34; 95% CI, 1.26-4.35; P = 0.007) were associated with reduced BMI (d-BMI < - 2). Treatment-related weight reduction in AML was associated with poor outcome after HSCT.

    DOI： 10.1007/s12185-019-02647-5

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  • Prognostic index for patients with relapsed or refractory acute myeloid leukemia who underwent hematopoietic cell transplantation: a KSGCT multicenter analysis. 査読 国際誌

    Tachibana T, Kanda J, Ishizaki T, Najima Y, Tanaka M, Doki N, Fujiwara SI, Kimura SI, Onizuka M, Takahashi S, Saito T, Mori T, Fujisawa S, Sakaida E, Matsumoto K, Aotsuka N, Goto M, Watanabe R, Shono K, Usuki K, Tsukada N, Kanamori H, Kanda Y, Okamoto S, Kanto Study, Group for Cell Therapy, KSGCT

    Leukemia   33 ( 11 )   2610 - 2618   2019年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41375-019-0494-9

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  • Employment status was highly associated with quality of life after allogeneic hematopoietic cell transplantation, and the association may differ according to patient age and graft-versus-host disease status: analysis of a nationwide QOL survey. 国際誌

    Saiko Kurosawa, Takuhiro Yamaguchi, Kumi Oshima, Atsumi Yanagisawa, Takahiro Fukuda, Heiwa Kanamori, Takehiko Mori, Satoshi Takahashi, Tadakazu Kondo, Shin Fujisawa, Yasushi Onishi, Shingo Yano, Makoto Onizuka, Yoshinobu Kanda, Ishikazu Mizuno, Shuichi Taniguchi, Takuya Yamashita, Yoshihiro Inamoto, Shinichiro Okamoto, Yoshiko Atsuta

    Bone marrow transplantation   54 ( 4 )   611 - 615   2019年4月

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  • Feasibility of the imatinib stop study in the Japanese clinical setting: delightedly overcome CML expert stop TKI trial (DOMEST Trial)

    Shin Fujisawa, Yasunori Ueda, Kensuke Usuki, Hajime Kobayashi, Eisei Kondo, Noriko Doki, Takafumi Nakao, Yoshinobu Kanda, Nobuharu Kosugi, Hiroshi Kosugi, Takashi Kumagai, Hiroshi Harada, Masato Shikami, Yasuhiro Maeda, Toru Sakura, Koiti Inokuchi, Akio Saito, Yuichiro Nawa, Masahiro Ogasawara, Junji Nishida, Takeshi Kondo, Chikashi Yoshida, Hiroyuki Kuroda, Yoko Tabe, Yoshinobu Maeda, Kenji Imajo, Kensuke Kojima, Satoshi Morita, Sho Komukai, Atsushi Kawaguchi, Junichi Sakamoto, Shinya Kimura

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   24 ( 4 )   445 - 453   2019年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s10147-018-1368-2

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  • Primary uterine lymphoma: The Yokohama Cooperative Study Group for Hematology (YACHT) study. 国際誌

    Yoshimi Ishii, Shin Fujisawa, Taiki Ando, Taisei Suzuki, Yasufumi Ishiyama, Kumiko Kishimoto, Yukako Hattori, Yuki Nakajima, Takuya Miyazaki, Hirotaka Takasaki, Kenji Matsumoto, Hideyuki Koharazawa, Jun Taguchi, Katsumichi Fujimaki, Rika Sakai, Hideaki Nakajima

    Asia-Pacific journal of clinical oncology   14 ( 5 )   e455-e459   2018年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    AIM: Primary malignant lymphomas arising from the female genital tract are very rare, with an incidence rate of 0.5%. Because of its rarity, its clinical characteristics, prognosis and optimal treatment are still unclear. Here, we retrospectively evaluated female patients with uterine lymphoma. METHODS: Between January 2000 and October 2016, 4362 patients were newly diagnosed with malignant lymphoma by the participating institutions of YACHT. Among these 4362 patients, we retrospectively evaluated 14 adult patients with primary uterine lymphoma. RESULTS: The median follow up time was 41 months. The median age at diagnosis was 68 years. Of 14 patients, 10 (72%) were diagnosed with diffuse large B-cell lymphoma. Seven patients presented with vaginal bleeding and three with abdominal pain. Eleven patients (79%) had advanced stages at diagnosis. Three patients (21%) had ovarian involvement and 2 (14%) had vaginal involvement. Induction chemotherapy regimens were R-CHOP in seven patients (50%), CHOP in three (21%) and other regimens in four (29%). Among 14 patients, 12 patients (86%) achieved a complete response and 2 (14%) experienced disease progression. Three patients (21%) showed relapse. Five patients (36%) died because of malignant lymphoma. The 3-year overall survival rate was 57.9%. Soluble interleukin-2 receptor levels > 5000 U/mL, anemia, a bulky mass and the presence of > 1 extranodal sites, B symptom at diagnosis were associated with a poor prognosis. CONCLUSION: Female genital lymphoma is very rare, and further study of more cases is warranted.

    DOI： 10.1111/ajco.13049

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  • t(4;11)(q21;q23)を伴う急性リンパ性白血病に対する同種造血幹細胞移植(Allogeneic hematopoietic stem cell transplantation in patients with B-ALL with t(4;11)(q21;q23))

    青木 淳, 藤澤 信, 水田 秀一, 小澤 幸泰, 大橋 一輝, 太田 秀一, 小川 啓恭, 福田 隆浩, 内田 直之, 田中 淳司, 熱田 由子, 賀古 真一

    臨床血液   59 ( 9 )   1553 - 1553   2018年9月

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    記述言語：英語   出版者・発行元：(一社)日本血液学会-東京事務局  

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  • 同種造血幹細胞移植におけるNTBIの臨床的有用性(Clinical role of NTBI during allogeneic hematopoietic stem cell transplantation)

    松村 彩子, 宮崎 拓也, 立花 崇孝, 畑山 真弓, 安藤 太基, 小山 めぐみ, 小山 哲, 石井 好美, 高橋 寛行, 中嶋 ゆき, 沼田 歩, 山本 渉, 本橋 賢治, 萩原 真紀, 松本 憲二, 生田 克哉, 藤澤 信, 中島 秀明

    臨床血液   59 ( 9 )   1812 - 1812   2018年9月

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    記述言語：英語   出版者・発行元：(一社)日本血液学会-東京事務局  

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  • 診断後1年の治療効果は2005年NIH診断基準による慢性GVHDにおける予後予測因子となりうる(A prognostic impact of complete or partial response at 1 year after onset in 2005 NIH chronic GVHD)

    大和田 千桂子, 堺田 惠美子, 五十嵐 愛子, 土岐 典子, 森 毅彦, 加藤 淳, 金森 平和, 田中 正嗣, 藤澤 信, 大草 恵理子, 豊崎 誠子, 青山 泰之, 神田 善伸, 仲宗根 秀樹, 萩原 真紀, 清水 啓明, 加藤 せい子, 渡部 玲子, 鐘野 勝洋, 酒井 リカ, 齋藤 健, 臼杵 憲祐, 中世古 知昭, 岡本 真一郎

    臨床血液   59 ( 9 )   1584 - 1584   2018年9月

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    記述言語：英語   出版者・発行元：(一社)日本血液学会-東京事務局  

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  • Anemia Associated with Worse Outcome in Diffuse Large B-Cell Lymphoma Patients: A Single-Center Retrospective Study 国際誌

    Kenji Matsumoto, Shin Fujisawa, Taiki Ando, Megumi Koyama, Satoshi Koyama, Yoshimi Ishii, Ayumi Numata, Wataru Yamamoto, Kenji Motohashi, Maki Hagihara, Hideaki Nakajima

    Turkish journal of haematology : official journal of Turkish Society of Haematology   35 ( 3 )   181 - 184   2018年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Objective: Useful prognostic biomarkers for diffuse large B-cell lymphoma (DLBCL) patients have been reported. To determine the prognostic value of hemoglobin (Hb) level in DLBCL patients, we performed a retrospective study. Materials and Methods: We evaluated disease outcome, progression-free survival (PFS), overall survival as the endpoint, and clinical and laboratory factors affecting the outcome of 185 DLBCL patients who had received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone therapy during 2004-2014. Results: The study group included 121 men and 64 women with a median age of 66 years minimum-maximum: 21-83 years. In univariate analysis, factors independently associated with worse PFS were Eastern Cooperative Oncology Group performance status ≥2, Ann Arbor stage III or IV, anemia with Hb levels of <10 g/dL, and serum albumin of <3.5 g/dL. In multivariate analysis, anemia with Hb levels of <10 g/dL and Ann Arbor stage III or IV were found to be international index-independent prognostic factors (hazard ratio: 2.4; p=0.04). Conclusion: Anemia is an independent prognostic marker of poor outcome in DLBCL patients. Hb can be an easily available prognostic marker for risk stratification in these patients.

    DOI： 10.4274/tjh.2017.0437

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  • Clinical Significance of Serum Ferritin at Diagnosis in Patients With Acute Myeloid Leukemia: A YACHT Multicenter Retrospective Study. 国際誌

    Takayoshi Tachibana, Taiki Andou, Masatsugu Tanaka, Satomi Ito, Takuya Miyazaki, Yoshimi Ishii, Eriko Ogusa, Hideyuki Koharazawa, Hiroyuki Takahashi, Kenji Motohashi, Jun Aoki, Yuki Nakajima, Kenji Matsumoto, Maki Hagihara, Chizuko Hashimoto, Jun Taguchi, Katsumichi Fujimaki, Hiroyuki Fujita, Shin Fujisawa, Heiwa Kanamori, Hideaki Nakajima

    Clinical lymphoma, myeloma & leukemia   18 ( 6 )   415 - 421   2018年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: A multicenter retrospective analysis was performed to evaluate the clinical significance of serum ferritin at diagnosis in patients with acute myeloid leukemia (AML). METHODS: The study cohort included 305 patients who were newly diagnosed with AML from 2000 to 2015 and received standard induction chemotherapy. Transplantation was performed in 168 patients. RESULTS: The median ferritin value was 512 ng/mL (range, 8-9475 ng/mL). Ferritin correlated with lactate dehydrogenase, C-reactive protein, white blood cell count, and blast count, and elevation of ferritin was associated with poor performance status. The median follow-up period was 58 months (range, 4-187 months) among survivors. The high ferritin group (≥ 400 ng/mL) demonstrated inferior event-free survival (EFS) at the 5-year interval (30% vs. 40%; P = .033) compared to the low ferritin group. Multivariate analysis in the high-risk karyotype revealed that high ferritin levels predicted worse EFS (hazard ratio = 2.07; 95% confidence interval, 1.28-3.33; P = .003). CONCLUSION: Elevated ferritin at diagnosis may indicate tumor burden in patients with AML and predict worse EFS in the high-risk group.

    DOI： 10.1016/j.clml.2018.03.009

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  • Cytogenetic risk stratification may predict allogeneic hematopoietic stem cell transplantation outcomes for chronic myelomonocytic leukemia. 査読 国際誌

    Kenji Motohashi, Shin Fujisawa, Noriko Doki, Takeshi Kobayashi, Takehiko Mori, Kensuke Usuki, Masatsugu Tanaka, Shinichiro Fujiwara, Shinichi Kako, Yasuyuki Aoyama, Masahiro Onoda, Shingo Yano, Moritaka Gotoh, Heiwa Kanamori, Satoshi Takahashi, Shinichiro Okamoto

    Leukemia & lymphoma   59 ( 6 )   1332 - 1337   2018年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative treatment for chronic myelomonocytic leukemia (CMML); however, factors predicting allo-HSCT outcomes for CMML have not been well defined. This study assessed whether the existing five scoring systems for CMML prognosis could be applied for predicting allo-HSCT outcomes. We retrospectively evaluated 38 patients who underwent allo-HSCT for CMML from 2000 to 2014. At 3 years, overall survival (OS) and disease-free survival were 34.6 and 24.7%, respectively. According to the risk stratification at the time of transplantation, only the CMML-specific cytogenetic risk scoring system could successfully predict transplantation outcomes. At 3 years, OS was 56.7, 12.5, and 0% (p = .01) in the low, intermediate, and high-risk groups. Our data suggest that the CMML-specific cytogenetic risk stratification at transplant may be useful for identifying patients with CMML who may benefit from HSCT. However, further studies are warranted to confirm this observation.

    DOI： 10.1080/10428194.2017.1387913

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  • Peripheral Blood Monocyte Count is a Predictor of Successful Peripheral Blood Stem Cell Harvest After Chemo-Mobilization in Patients with Malignant Lymphoma. 国際誌

    Yoshimi Ishii, Shin Fujisawa, Chika Nigauri, Taiki Ando, Taisei Suzuki, Eriko Ogusa, Kazuho Miyashita, Kenji Motohashi, Hideaki Nakajima

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion   34 ( 2 )   347 - 349   2018年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s12288-017-0848-2

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  • Regulatory T cell inhibition by dasatinib is associated with natural killer cell differentiation and a favorable molecular response-The final results of the D-first study. 国際誌

    Yuho Najima, Chikashi Yoshida, Noriyoshi Iriyama, Shin Fujisawa, Hisashi Wakita, Shigeru Chiba, Shinichiro Okamoto, Kimihiro Kawakami, Naoki Takezako, Takashi Kumagai, Kazuma Ohyashiki, Jun Taguchi, Shingo Yano, Tadahiko Igarashi, Yasuji Kouzai, Satoshi Morita, Junichi Sakamoto, Hisashi Sakamaki, Koiti Inokuchi

    Leukemia research   66   66 - 72   2018年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    We evaluated the effects of regulatory T cell (Treg) inhibition during dasatinib treatment on the anticancer immune response, particularly on natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Fifty-two newly diagnosed Japanese patients with chronic myeloid leukemia (CML) in the chronic phase were enrolled in the D-first study; all received 100 mg of dasatinib once daily and were followed for at least 36 months. The cumulative deep molecular response (DMR, MR4) rate was 65% by 36 months; the 3-year overall survival was 96%. CD4+ T cell counts were stable, whereas the proportion of CD4+CD25+CD127low (Treg) cells decreased in a time-dependent manner. The DMR rate by18 months was significantly better in low Treg patients (<5.7% at 12 months) compared to the remaining patients (odds ratio 4.07). NK cell and CTL counts at several time points were inversely correlated with Treg counts. Furthermore, the degree of NK cell differentiation (CD3-CD57+/CD3-CD56+) was closely and inversely correlated with the proportion of Treg cells throughout the observation period, and showed a gradually increasing trend. In conclusion, our results demonstrate that Treg inhibition by dasatinib contributes to better treatment response through enhancement of the immune system, particularly via NK cell differentiation.

    DOI： 10.1016/j.leukres.2018.01.010

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  • Outcome and prognostic factors among patients who underwent a second transplantation for disease relapse post the first allogeneic cell transplantation 査読

    Takayoshi Tachibana, Kenji Matsumoto, Masatsugu Tanaka, Maki Hagihara, Kenji Motohashi, Wataru Yamamoto, Eriko Ogusa, Satoshi Koyama, Ayumi Numata, Naoto Tomita, Jun Taguchi, Shin Fujisawa, Heiwa Kanamori, Hideaki Nakajima

    LEUKEMIA & LYMPHOMA   58 ( 6 )   1403 - 1411   2017年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1080/10428194.2016.1243678

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  • Dasatinib versus imatinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia: a subanalysis of the DASISION 5-year final report 査読

    Hirohisa Nakamae, Shin Fujisawa, Michinori Ogura, Toshiki Uchida, Yasushi Onishi, Masafumi Taniwaki, Atae Utsunomiya, Kosei Matsue, Yasushi Takamatsu, Kensuke Usuki, Mitsune Tanimoto, Yoji Ishida, Kazuteru Ohashi, Li Li, Masafumi Miyoshi

    INTERNATIONAL JOURNAL OF HEMATOLOGY   105 ( 6 )   792 - 804   2017年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s12185-017-2208-2

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  • Body mass index is a prognostic factor in adult patients with acute myeloid leukemia 査読

    Taiki Ando, Etsuko Yamazaki, Eriko Ogusa, Yoshimi Ishii, Wataru Yamamoto, Kenji Motohashi, Takayoshi Tachibana, Maki Hagihara, Kenji Matsumoto, Masatsugu Tanaka, Chizuko Hashimoto, Hideyuki Koharazawa, Katsumichi Fujimaki, Jun Taguchi, Hiroyuki Fujita, Heiwa Kanamori, Shin Fujisawa, Hideaki Nakajima

    INTERNATIONAL JOURNAL OF HEMATOLOGY   105 ( 5 )   623 - 630   2017年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s12185-017-2183-7

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  • Phase II study of imatinib-based chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia 査読

    Shin Fujisawa, Shuichi Mizuta, Hideki Akiyama, Yasunori Ueda, Yasutaka Aoyama, Yoshihiro Hatta, Kazuhiko Kakihana, Nobuaki Dobashi, Isamu Sugiura, Yasushi Onishi, Tomoya Maeda, Kiyotoshi Imai, Shigeki Ohtake, Yasushi Miyazaki, Kazunori Ohnishi, Keitaro Matsuo, Tomoki Naoe

    AMERICAN JOURNAL OF HEMATOLOGY   92 ( 4 )   367 - 374   2017年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/ajh.24653

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  • 成人急性リンパ性白血病の治療戦略

    藤澤 信

    臨床血液   58 ( 10 )   1983 - 1994   2017年

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    記述言語：日本語   出版者・発行元：一般社団法人 日本血液学会  

    <p>急性リンパ性白血病（ALL）は小児領域では治療成績の劇的な改善が認められ化学療法による治癒も期待されているが，成人領域においては改善が乏しく治癒には同種移植によるところが大きい。しかし，最近は若年成人に対する小児用レジメンにより良好な成績が報告されており，その上で成人ALLに対する小児用レジメンが予後の改善をもたらすことが期待されている。成人領域におけるT細胞性ALLは極めて稀少疾患であり，T-ALLに限定された大規模な前向き臨床成績は報告されていない。しかし本邦においてはネララビン併用化学療法の前向き試験が進行中である。また，フィラデルフィア染色体陽性ALLは以前は予後不良とされていたが，チロシンキナーゼ阻害剤の登場により殆どの症例が完全寛解に導入されるようになった。再発・難治ALLについても新規薬剤が開発され予後が改善されつつある。本稿においては現在までの成人ALL治療の進歩と今後について概説する。</p>

    DOI： 10.11406/rinketsu.58.1983

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  • Hyper-recovery of platelets after induction therapy is a predictor of relapse-free survival in acute myeloid leukemia 査読

    Etsuko Yamazaki, Heiwa Kanamori, Megumi Itabashi, Eriko Ogusa, Ayumi Numata, Wataru Yamamoto, Satomi Ito, Takayoshi Tachibana, Maki Hagihara, Kenji Matsumoto, Hideyuki Koharazawa, Jun Taguchi, Naoto Tomita, Katsumichi Fujimaki, Hiroyuki Fujita, Shin Fujisawa, Koji Ogawa, Yoshiaki Ishigatsubo

    LEUKEMIA & LYMPHOMA   58 ( 1 )   104 - 109   2017年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1080/10428194.2016.1190969

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  • The SIL index is a simple and objective prognostic indicator in diffuse large B-cell lymphoma 査読

    Naoto Tomita, Taisei Suzuki, Kazuho Miyashita, Wataru Yamamoto, Kenji Motohashi, Takayoshi Tachibana, Hirotaka Takasaki, Rika Kawasaki, Maki Hagihara, Chizuko Hashimoto, Sachiya Takemura, Hideyuki Koharazawa, Etsuko Yamazaki, Jun Taguchi, Katsumichi Fujimaki, Hiroyuki Fujita, Rika Sakai, Shin Fujisawa, Shigeki Motomura, Keisuke Kawamoto, Hirohito Sone, Jun Takizawa

    LEUKEMIA & LYMPHOMA   57 ( 12 )   2763 - 2770   2016年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1080/10428194.2016.1195498

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  • Residual Blast Cells in Bone Marrow on Day 15 Following Remission Induction Therapy for Acute Myeloid Leukemia Is Associated with Long-Term Prognosis: A Retrospective Analysis of the JALSG AML201 Study 査読

    Maki Hagihara, Shin Fujisawa, Sumihisa Honda, Shigeki Ohtake, Shuichi Miyawaki, Nobuaki Dobashi, Toru Sakura, Yukiyasu Ozawa, Yoshikazu Ito, Katsumichi Fujimaki, Asao Hirose, Hiroyuki Fujita, Kinya Ohata, Tomoya Maeda, Toshi Imai, Hitoshi Kiyoi, Yasushi Miyazaki, Kazunori Ohnishi, Tomoki Naoe, Hideaki Nakajima

    BLOOD   128 ( 22 )   2016年12月

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  • Outcome of Newly Diagnosed Acute Myeloid Leukemia with Hyperleukocytosis: Retrospective Study of JALSG AML201 査読

    Kenji Matsumoto, Shin Fujisawa, Maki Hagihara, Sumihisa Honda, Shigeki Ohtake, Shuichi Miyawaki, Toru Sakura, Dobashi Nobuaki, Kinya Ohata, Yukiyasu Ozawa, Iekuni Ou, Asao Hirose, Tomoya Maeda, Yoshikazu Ito, Noriko Doki, Hitoshi Kiyoi, Kazunori Ohnishi, Tomoki Naoe, Yasushi Miyazaki, Hideaki Nakajima

    BLOOD   128 ( 22 )   2016年12月

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  • Favorable prognosis in Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia patients following hematopoietic stem cell transplantation. 査読 国際誌

    Numata A, Fujisawa S, Itabashi M, Ishii Y, Yamamoto W, Motohashi K, Matsumoto K, Hagihara M, Nakajima H

    Clinical transplantation   30 ( 5 )   485 - 486   2016年5月

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    記述言語：英語  

    DOI： 10.1111/ctr.12702

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  • Allogeneic Hematopoietic Stem Cell Transplantation after Conditioning Regimens with Fludarabine/melphalan or Fludarabine/busulfan for Patients with Hematological Malignancies: A Single-center Analysis 査読

    Wataru Yamamoto, Taiki Andou, Megumi Itabashi, Satoshi Koyama, Yoshimi Ishii, Ayumi Numata, Kenji Motohashi, Maki Hagihara, Kenji Matsumoto, Shin Fujisawa

    INTERNAL MEDICINE   55 ( 13 )   1721 - 1727   2016年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.2169/internalmedicine.55.6094

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  • Cytomegalovirus Pneumonia after Anti-CC-chemokine Receptor 4 Monoclonal Antibody (Mogamulizumab) Therapy in an Angioimmunoblastic T-cell Lymphoma Patient 査読

    Yoshimi Ishii, Megumi Itabashi, Ayumi Numata, Wataru Yamamoto, Kenji Motohashi, Maki Hagihara, Kenji Matsumoto, Shin Fujisawa

    INTERNAL MEDICINE   55 ( 6 )   673 - 675   2016年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.2169/internalmedicine.55.5644

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  • Effectiveness of High-Dose MTX Therapy for Adult Ph-Negative ALL By Randomized Trial: JALSG ALL202-O 査読

    Toru Sakura, Fumihiko Hayakawa, Isamu Sugiura, Kiyotoshi Imai, Noriko Usui, Shin Fujisawa, Tohru Murayama, Toshiaki Yujiri, Hitoshi Kiyoi, Kazunori Ohnishi, Yasushi Miyazaki, Shigeki Ohtake, Yukio Kobayashi, Keitaro Matsuo, Tomoki Naoe

    BLOOD   126 ( 23 )   2015年12月

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    記述言語：英語  

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  • Clinical significance of the administration of cytarabine or thiotepa in addition to total body irradiation and cyclophosphamide for allogeneic hematopoietic cell transplantation in patients with acute leukemia 査読

    Takayoshi Tachibana, Masatsugu Tanaka, Maki Hagihara, Rika Kawasaki, Etsuko Yamazaki, Hideyuki Koharazawa, Jun Taguchi, Naoto Tomita, Katsumichi Fujimaki, Rika Sakai, Hiroyuki Fujita, Shin Fujisawa, Atsuo Maruta, Yoshiaki Ishigatsubo, Heiwa Kanamori

    INTERNATIONAL JOURNAL OF HEMATOLOGY   102 ( 4 )   451 - 459   2015年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s12185-015-1836-7

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  • Patient-reported quality of life after allogeneic hematopoietic cell transplantation or chemotherapy for acute leukemia 査読

    S. Kurosawa, T. Yamaguchi, T. Mori, H. Kanamori, Y. Onishi, N. Emi, S. Fujisawa, A. Kohno, C. Nakaseko, B. Saito, T. Kondo, M. Hino, Y. Nawa, S. Kato, A. Hashimoto, T. Fukuda

    BONE MARROW TRANSPLANTATION   50 ( 9 )   1241 - 1249   2015年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/bmt.2015.137

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  • Clinical significance of pretransplant serum ferritin on the outcome of allogeneic hematopoietic SCT: A prospective cohort study by the Kanto Study Group for Cell Therapy

    M. Tanaka, H. Kanamori, K. Matsumoto, T. Tachibana, A. Numata, K. Ohashi, T. Kobayashi, C. Nakaseko, Y. Kanda, E. Yamazaki, S. Fujisawa, J. Ooi, T. Sakura, N. Aotsuka, M. Onoda, S. Machida, J. Kato, K. Usuki, R. Watanabe, J. Taguchi, S. Yano, T. Saito, S. Takahashi, H. Sakamaki, S. Okamoto

    Bone Marrow Transplantation   50 ( 5 )   727 - 733   2015年5月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/bmt.2015.17

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  • [Analysis of prognostic factors in transplant-eligeble newly diagnosed myeloma patients treated with bortezomib plus dexamethasone as induction therapy]. 査読

    Koharazawa H, Watanabe R, Hattori Y, Numata A, Kawasaki R, Kuwabara H, Hagihara M, Matsumoto K, Tanaka M, Hashimoto C, Takemura S, Yamazaki E, Fujimaki K, Taguchi J, Tomita N, Fujita H, Sakai R, Harano H, Ishigatsubo Y, Fujisawa S

    [Rinsho ketsueki] The Japanese journal of clinical hematology   56 ( 4 )   392 - 399   2015年4月

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  • ボルテゾミブとデキサメタゾンの併用による寛解導入療法を施行した移植適応新規骨髄腫症例における予後規定因子の検討

    小原澤 英之, 渡邊 玲奈, 服部 友歌子, 沼田 歩, 川崎 理加, 桑原 英幸, 萩原 真紀, 松本 憲二, 田中 正嗣, 橋本 千寿子, 竹村 佐千哉, 山崎 悦子, 藤巻 克通, 田口 淳, 富田 直人, 藤田 浩之, 酒井 リカ, 原野 浩, 石ヶ坪 良明, 藤澤 信

    臨床血液   56 ( 4 )   392 - 399   2015年4月

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  • Shorter halving time of BCR-ABL1 transcripts is a novel predictor for achievement of molecular responses in newly diagnosed chronic-phase chronic myeloid leukemia treated with dasatinib: Results of the D-first study of Kanto CML study group 査読

    Iriyama, Noriyoshi, Fujisawa, Shin, Yoshida, Chikashi, Wakita, Hisashi, Chiba, Shigeru, Okamoto, Shinichiro, Kawakami, Kimihiro, Takezako, Naoki, Kumagai, Takashi, Inokuchi, Koiti, Ohyashiki, Kazuma, Taguchi, Jun, Yano, Shingo, Igarashi, Tadahiko, Kouzai, Yasuji, Morita, Satoshi, Sakamoto, Junichi, Sakamaki, Hisashi

    AMERICAN JOURNAL OF HEMATOLOGY   90 ( 4 )   282 - 287   2015年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

    DOI： 10.1002/ajh.23923

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  • A Safety and Efficacy Study of Medium-Dose Etoposide, Cyclophosphamide and Total Body Irradiation Conditioning Before Allogeneic Stem Cell Transplantation for Acute Lymphoblastic Leukemia. 国際誌

    Akio Shigematsu, Yukiyasu Ozawa, Makoto Onizuka, Shin Fujisawa, Ritsuro Suzuki, Yoshiko Atsuta, Kazuo Hatanaka, Masayoshi Masuko, Toshiro Ito, Naoki Kobayashi, Jun Kato, Koichi Miyamura, Takahiro Fukuda, Yasuo Morishima, Masahiro Imamura

    Transplantation direct   1 ( 2 )   e8   2015年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    UNLABELLED: Prognosis for adult patients with acute lymphoblastic leukemia (ALL) has been reported to be approximately 35% to 50%, even after allogeneic stem cell transplantation (allo-SCT). We previously reported retrospective analyses of a conditioning regimen of medium-dose etoposide, cyclophosphamide (CY), and total body irradiation (TBI) before allo-SCT for ALL. To prospectively analyze the efficacy of this conditioning regimen, we conducted a trial prospectively. METHODS: The eligibility criteria of this study were as follows: diagnosis of ALL, aged between 15 and 50 years, in complete remission, and first SCT from HLA serologically matched donor. The primary endpoint of this study was event-free survival at 1 year after SCT, and the events were defined as death and relapse. RESULTS: Fifty eligible patients were treated, and the median age of the patients was 33.5 years. Nineteen patients were Philadelphia chromosome-positive, and 47 were in first complete remission at SCT. All patients achieved neutrophil engraftment. Grade 3 to 4 acute graft-versus-host disease and extensive chronic graft-versus-host disease developed in 4 patients and 18 patients, respectively. No patient died within 100 days after SCT. One-year event-free survival was 76.0%, and 1-year overall survival was 80.0%. The cumulative incidences of relapse and non-relapse mortality at 1-year after SCT were 10.0% and 14.0%, respectively. CONCLUSIONS: Medium-dose etoposide + CY + TBI is an effective conditioning before allo-SCT for adult patients with ALL, enabling good disease control without an increase in nonrelapse mortality. A phase 3 trial comparing this regimen with the standard CY + TBI regimen for adult patients with ALL is warranted.

    DOI： 10.1097/TXD.0000000000000514

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  • Post-therapy ¹⁸F-fluorodeoxyglucose positron emission tomography for predicting outcome in patients with peripheral T cell lymphoma. 国際誌

    Naoto Tomita, Yukako Hattori, Shin Fujisawa, Chizuko Hashimoto, Jun Taguchi, Hirotaka Takasaki, Rika Sakai, Ukihide Tateishi, Yoshiaki Ishigatsubo

    Annals of hematology   94 ( 3 )   431 - 6   2015年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The International Harmonization Project on Lymphoma recommends (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) for the routine assessment of treatment efficacy in patients with FDG-avid lymphomas such as Hodgkin's and diffuse large B cell lymphomas. The utility of FDG-PET in predicting outcomes in patients with peripheral T cell lymphomas (PTCL) has not been fully elucidated. We retrospectively determined the predictive value of FDG-PET after first-line treatment (post-PET) for outcome in PTCL. Of the 36 patients enrolled, 16 were histologically diagnosed with PTCL not otherwise specified and 20 were diagnosed with angioimmunoblastic T cell lymphoma. All patients received curative-intent anthracycline-containing chemotherapy regimens. Post-PET images were visually evaluated by local nuclear medicine physicians. The median observation period for the surviving patients was 44 months. Positive and negative post-PET results were obtained in 31 % (11/36) and 69 % (25/36) of patients, respectively. The 3-year progression-free survival rates in the positive and negative post-PET result groups were 18 % and 62 %, respectively (P < 0.001). Nine of the 11 patients in the positive post-PET result group experienced progressive disease (PD) (positive predictive value, 82 %), whereas 16 of the 25 patients in the negative post-PET result group did not experience PD (negative predictive value, 64 %). The 3-year overall survival rates in the positive and negative post-PET result groups were 44 % and 84 %, respectively (P = 0.03). Our findings indicate that post-PET is predictive of outcome in patients with PTCL.

    DOI： 10.1007/s00277-014-2227-5

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  • Analysis of outcomes in patients with supra-diaphragmatic vs infra-diaphragmatic diffuse large B cell lymphoma treated with R-CHOP therapy 査読

    Yuki Nakajima, Naoto Tomita, Megumi Itabashi, Kazuho Miyashita, Reina Watanabe, Takuya Miyazaki, Takayoshi Tachibana, Hirotaka Takasaki, Rika Kawasaki, Masatsugu Tanaka, Chizuko Hashimoto, Etsuko Yamazaki, Jun Taguchi, Katsumichi Fujimaki, Rika Sakai, Hiroyuki Fujita, Shin Fujisawa, Hiroshi Harano, Shigeki Motomura, Yoshiaki Ishigatsubo

    LEUKEMIA RESEARCH   39 ( 2 )   198 - 203   2015年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.leukres.2014.11.030

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  • Does the Hematopoietic Cell Transplantation Specific Comorbidity Index (HCT-CI) Predict Transplantation Outcomes? A Prospective Multicenter Validation Study of the Kanto Study Group for Cell Therapy 査読

    Nakaya, Aya, Mori, Takehiko, Tanaka, Masatsugu, Tomita, Naoto, Nakaseko, Chiaki, Yano, Shingo, Fujisawa, Shin, Sakamaki, Hisashi, Aotsuka, Nobuyuki, Yokota, Akira, Kanda, Yoshinobu, Sakura, Toru, Nanya, Yasuhito, Saitoh, Takayuki, Kanamori, Heiwa, Taka

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   20 ( 10 )   1553 - 1559   2014年10月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.bbmt.2014.06.005

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  • Serum ferritin level is prognostic of patient outcome in extranodal NK/T cell lymphoma, nasal type

    Etsuko Yamazaki, Naoto Tomita, Satoshi Koyama, Eriko Ogusa, Yoshimi Ishii, Hiroyuki Takahashi, Kazuho Miyashita, Shiro Matsuura, Takayoshi Tachibana, Hirotaka Takasaki, Sachiya Takemura, Katsumichi Fujimaki, Rika Sakai, Shin Fujisawa, Yoshiaki Ishigatsubo

    Medical Oncology   31 ( 9 )   1 - 7   2014年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Humana Press Inc.  

    DOI： 10.1007/s12032-014-0149-7

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  • Efficacy and safety of dasatinib versus imatinib in Japanese patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML-CP): Subset analysis of the DASISION trial with 2-year follow-up 査読

    Shin Fujisawa, Hirohisa Nakamae, Michinori Ogura, Ken-ichi Ishizawa, Masafumi Taniwaki, Atae Utsunomiya, Kosei Matsue, Yasushi Takamatsu, Kensuke Usuki, Mitsune Tanimoto, Yoji Ishida, Hideki Akiyama, Shintaro Onishi

    INTERNATIONAL JOURNAL OF HEMATOLOGY   99 ( 2 )   141 - 153   2014年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s12185-013-1470-1

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  • Relative increase in lymphocytes from as early as 1 month predicts improved response to dasatinib in chronic-phase chronic myelogenous leukemia. 査読

    Takashi Kumagai, Eri Matsuki, Koiti Inokuchi, Kazuteru Ohashi, Atsushi Shinagawa, Jin Takeuchi, Chikashi Yoshida, Shinichiro Okamoto, Hisashi Wakita, Yasuji Kozai, Yukari Shirasugi, Shin Fujisawa, Osamu Iwase, Shingo Yano, Kaichi Nishiwaki, Koji Oba, Junichi Sakamoto, Hisashi Sakamaki

    International journal of hematology   99 ( 1 )   41 - 52   2014年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s12185-013-1483-9

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  • European Treatment and Outcome Study score does not predict imatinib treatment response and outcome in chronic myeloid leukemia patients. 国際誌

    Eri Yamamoto, Shin Fujisawa, Maki Hagihara, Masatsugu Tanaka, Katsumichi Fujimaki, Kumiko Kishimoto, Chizuko Hashimoto, Megumi Itabashi, Daisuke Ishibashi, Yuki Nakajima, Takayoshi Tachibana, Rika Kawasaki, Hideyuki Kuwabara, Hideyuki Koharazawa, Etsuko Yamazaki, Naoto Tomita, Rika Sakai, Hiroyuki Fujita, Heiwa Kanamori, Yoshiaki Ishigatsubo

    Cancer science   105 ( 1 )   105 - 9   2014年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The Sokal and Hasford scores were developed in the chemotherapy and interferon era and are widely used as prognostic indicators in patients with chronic myeloid leukemia (CML). Recently, a new European Treatment and Outcome Study (EUTOS) scoring system was developed. We performed a multicenter retrospective study to validate the effectiveness of each of the three scoring systems. The study cohort included 145 patients diagnosed with CML in chronic phase who were treated with imatinib. In the EUTOS low- and high-risk groups, the cumulative incidence of complete cytogenetic response (CCyR) at 18 months was 86.9% and 87.5% (P = 0.797) and the 5-year overall survival rate was 92.6% and 93.3% (P = 0.871), respectively. The cumulative incidence of CCyR at 12 months, 5-year event-free survival and 5-year progression-free survival were not predicted using the EUTOS scoring system. However, there were significant differences in both the Sokal score and Hasford score risk groups. In our retrospective validation study, the EUTOS score did not predict the prognosis of patients with CML in chronic phase treated with imatinib.

    DOI： 10.1111/cas.12321

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  • Cord colitis syndromeを合併した急性骨髄性白血病

    田中 正嗣, 桑原 英幸, 立花 崇孝, 本橋 賢治, 中嶋 ゆき, 沼田 歩, 岸本 久美子, 藤澤 信, 大島 理加, 石ヶ坪 良明

    神奈川医学会雑誌   41 ( 1 )   112 - 113   2014年1月

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    記述言語：日本語   出版者・発行元：(公社)神奈川県医師会  

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  • Clinical significance of pre- and 1-year post-transplant serum ferritin among adult transplant recipients

    Takayoshi Tachibana, Masatsugu Tanaka, Ayumi Numata, Kenji Matsumoto, Naoto Tomita, Katsumichi Fujimaki, Jun Taguchi, Rika Sakai, Hiroyuki Fujita, Shin Fujisawa, Atsuo Maruta, Yoshiaki Ishigatsubo, Heiwa Kanamori

    Leukemia and Lymphoma   55 ( 6 )   1350 - 1356   2014年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Informa Healthcare  

    DOI： 10.3109/10428194.2013.842981

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  • Validation of the European Group for Blood and Marrow Transplantation (EBMT) risk score in patients receiving allogeneic hematopoietic stem cell transplantation at a single center in Japan

    Ayumi Numata, Masatsugu Tanaka, Kenji Matsumoto, Hirotaka Takasaki, Takayoshi Tachibana, Katsumichi Fujimaki, Rika Sakai, Shin Fujisawa, Naoto Tomita, Hiroyuki Fujita, Atsuo Maruta, Yoshiaki Ishigatsubo, Heiwa Kanamori

    Clinical Transplantation   28 ( 4 )   403 - 409   2014年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Blackwell Publishing Ltd  

    DOI： 10.1111/ctr.12324

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  • Efficacy of molecular response at 1 or 3 months after the initiation of dasatinib treatment can predict an improved response to dasatinib in imatinib-resistant or imatinib-intolerant Japanese patients with chronic myelogenous leukemia during the chronic phase.

    Koiti Inokuchi, Takashi Kumagai, Eri Matsuki, Kazuteru Ohashi, Atsushi Shinagawa, Yoshihiro Hatta, Jin Takeuchi, Chikashi Yoshida, Hisashi Wakita, Yasuji Kozai, Yukari Shirasugi, Shin Fujisawa, Osamu Iwase, Shingo Yano, Shinichiro Okamoto, Koji Oba, Junichi Sakamoto, Hisashi Sakamaki

    Journal of clinical and experimental hematopathology : JCEH   54 ( 3 )   197 - 204   2014年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Dasatinib is a BCR-ABL kinase inhibitor with improved potency compared with imatinib, for which efficacy and safety in imatinib-resistant and imatinib-intolerant patients with chronic myelogenous leukemia (CML) have been established. Here, an open-label phase II study evaluated the efficacy and safety of dasatinib in 50 Japanese patients with imatinib-resistant or imatinib-intolerant CML during the chronic phase (CML-CP). Dasatinib was effective in imatinib-resistant and imatinib-intolerant patients. After 12 months of dasatinib therapy, 35 patients (70%) had achieved a major molecular response (MMR) and 16 patients (32%) had achieved a complete molecular response (CMR). Among the imatinib-resistant CML-CP cohort, 21 and 8 patients had achieved an MMR and a CMR after 12 months of dasatinib therapy, respectively. Among the imatinib-intolerant CML-CP cohort, 14 and 8 patients had achieved an MMR and a CMR after 12 months of dasatinib therapy, respectively. After 18 months of dasatinib therapy, 38 out of 50 patients (76.0%) had achieved an MMR and 19 patients (38.0%) had achieved a CMR. A lower level of BCR-ABL transcript at 1 or 3 months after the initiation of dasatinib treatment was more strongly correlated with the BCR-ABL transcript level at 12 and 18 months (p ＜ 0.001) than a higher level of BCR-ABL. The T315I mutation was identified in two patients receiving dasatinib therapy. Dasatinib was generally well tolerated, with only 3 patients (5%) having treatment discontinuation as a result of adverse hematologic events (thrombocytopenia, anemia, neutropenia) and/or non-hematologic events at a 12-month follow-up evaluation. Dasatinib was a safe and effective treatment for Japanese patients with imatinib-resistant or imatinib-intolerant CML. In addition, the molecular response at 1 or 3 months predicted a response to dasatinib at 12 or 18 months.

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  • The Transcription Factor IRF8 Counteracts BCR-ABL to Rescue Dendritic Cell Development in Chronic Myelogenous Leukemia 査読

    Tomoya Watanabe, Chie Hotta, Shin-ichi Koizumi, Kazuho Miyashita, Jun Nakabayashi, Daisuke Kurotaki, Go R. Sato, Michio Yamamoto, Masatoshi Nakazawa, Hiroyuki Fujita, Rika Sakai, Shin Fujisawa, Akira Nishiyama, Zenro Ikezawa, Michiko Aihara, Yoshiaki Ishigatsubo, Tomohiko Tamura

    CANCER RESEARCH   73 ( 22 )   6642 - 6653   2013年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1158/0008-5472.CAN-13-0802

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  • Concentrated ascites reinfusion therapy for sinusoidal obstructive syndrome after hematopoietic stem cell transplantation. 国際誌

    Hiroyuki Takahashi, Rika Sakai, Atsuko Fujita, Hideyuki Kuwabara, Yukako Hattori, Shiro Matsuura, Rika Ohshima, Maki Hagihara, Naoto Tomita, Yoshiaki Ishigatsubo, Shin Fujisawa

    Artificial organs   37 ( 10 )   932 - 6   2013年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Sinusoidal obstruction syndrome (SOS) is one of the severe complications of hematopoietic stem cell transplantation (HSCT). Systemic management including respiratory and circulatory support is necessary. In addition, abdominal paracentesis is often needed for pain relief and to reduce the pressure of tense ascites. Concentrated ascites reinfusion therapy (CART) involves the filtration, concentration, and reinfusion of drained ascites, which contributes to reuse of autologous proteins. CART has been reported as supportive therapy for patients with liver cirrhosis and cancer. We retrospectively reviewed the efficacy and safety of CART in three patients (two with acute myelogenous leukemia and one with chronic myeloid leukemia) who developed SOS after allo-HSCT. They all had symptomatic, tense, and diuretic-refractory ascites with right costal pain and marked weight gain. Two patients showed immediate improvement after CART. However, one patient experienced four CARTs with slow recovery. All patients are now alive and are being monitored as outpatients over 2 years with remission. No severe adverse event was observed related to CART, and 25.2-98.0 (median 30.2) grams of albumin was collected and reinfused. CART after paracentesis reduces protein loss in ascites by reinfusion of autologous protein instead of exogenous albumin preparations. Although transient fever is reported as a frequent adverse event, no events like severe bleeding or infection were observed. While its safety has not been fully established in patients with hematological disease after HSCT, CART may be a considerable supportive therapy for SOS with tense ascites.

    DOI： 10.1111/aor.12080

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  • Absolute monocyte count in follicular lymphoma patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone 査読

    Reina Watanabe, Naoto Tomita, Kumiko Kishimoto, Satoshi Koyama, Eriko Ogusa, Yoshimi Ishii, Kazuho Miyashita, Shiro Matsuura, Shin Fujisawa, Yukako Hattori, Hirotaka Takasaki, Atsuko Fujita, Rika Ohshima, Hideyuki Kuwabara, Chizuko Hashimoto, Katsumichi Fujimaki, Rika Sakai, Yoshiaki Ishigatsubo

    LEUKEMIA RESEARCH   37 ( 10 )   1208 - 1212   2013年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.leukres.2013.07.015

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  • Prognosis of patients with core binding factor acute myeloid leukemia after first relapse. 国際誌

    Saiko Kurosawa, Shuichi Miyawaki, Takuhiro Yamaguchi, Heiwa Kanamori, Toru Sakura, Yukiyoshi Moriuchi, Fumiaki Sano, Takeshi Kobayashi, Atsushi Yasumoto, Kazuo Hatanaka, Masamitsu Yanada, Yuichiro Nawa, Jin Takeuchi, Yukinori Nakamura, Shin Fujisawa, Hirohiko Shibayama, Ikuo Miura, Takahiro Fukuda

    Haematologica   98 ( 10 )   1525 - 31   2013年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Core binding factor acute myeloid leukemia is known to have a favorable prognosis, however, there have been no detailed analyses on prognostic factors after first relapse. Using a nationwide database, we retrospectively analyzed core binding factor acute myeloid leukemia patients who relapsed after being treated with chemotherapy alone during their first complete remission. Of a total of 397 patients who were diagnosed with core binding factor acute myeloid leukemia, 208 experienced a first relapse, and analyses were performed in 139 patients for whom additional data were available. In the entire cohort, the overall survival rate after relapse was 48% at 3 years. By multivariate analysis, younger age at diagnosis, a longer interval before relapse, and inv(16) were shown to be independently associated with better survival after relapse. Although there was no significant difference in survival after relapse between patients who underwent allogeneic hematopoietic cell transplantation and those who did not in the overall series of relapsed patients, we found that transplantation significantly improved survival among patients who had t(8;21) (54% versus 26% at 3 years, P=0.002). In addition, among patients with t(8;21), those who had different cytogenetics at relapse had a significantly improved survival after transplantation, while those who had same cytogenetics did not. We showed that the prognosis differs significantly and optimal treatment strategies may vary between groups of patients with core binding factor acute myeloid leukemia with different cytogenetic profiles at relapse. These findings may help to guide therapeutic decisions after first relapse.

    DOI： 10.3324/haematol.2012.078030

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  • Drug-induced liver injury after allogeneic bone marrow transplantation 査読

    Takayoshi Tachibana, Akito Nozaki, Makiko Enaka, Eri Yamamoto, Rika Kawasaki, Hideyuki Koharazawa, Maki Hagihara, Daisuke Ishibashi, Yuki Nakajima, Hideyuki Kuwabara, Naoto Tomita, Yoshiaki Ishigatsubo, Shin Fujisawa

    INTERNATIONAL JOURNAL OF HEMATOLOGY   98 ( 4 )   499 - 503   2013年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s12185-013-1434-5

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  • Standard R-CHOP Therapy in Follicular Lymphoma and Diffuse Large B-Cell Lymphoma

    TOMITA Naoto, TAKASAKI Hirotaka, FUJISAWA SHIN, MIYASHITA Kazuho, OGUSA Eriko, KISHIMOTO Kumiko, MATSUURA Shiro, SAKAI Rika, KOHARAZAWA Hideyuki, YAMAMOTO Wataru, FUJIMAKI Katsumichi, FUJITA Hiroyuki, ISHII Yoshimi, TAGUCHI Jun, KUWABARA Hideyuki, MOTOMURA Shigeki, ISHIGATSUBO Yoshiaki

    Journal of clinical and experimental hematopathology   53 ( 2 )   121 - 125   2013年8月

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    記述言語：英語   出版者・発行元：The Japanese Society for Lymphoreticular Tissue Research  

    The introduction of rituximab (R) has measurably improved the outcome of patients with follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). To evaluate the outcome of patients with FL and DLBCL under R plus CHOP therapy, we performed a retrospective analysis in Yokohama City University Hematology Group in Japan. Five hundred and twenty-six patients (158, FL ; 368, DLBCL) were scheduled to undergo primary therapy with 6 cycles of full-dose R-CHOP therapy with curative intent. The median observation periods in livingpatients with FL and DLBCL were 45 months and 43 months, respectively. The complete response, 5-year progression-free survival (PFS), and 5-year overall survival (OS) rates were 86%, 50%, and 92% in the FL group, and 89%, 72%, and 80% in the DLBCL group, respectively. Although PFS was significantly better in the DLBCL group than in the FL group, OS was significantly better in FL patients. We also found that the OS and PFS of grade 3 FL patients were not statistically different from those with grade 1-2. These findings indicate that all grades of FL should be categorized simply as "FL" with regard to R-CHOP therapy. Our results also demonstrate the incurability of FL (grade 1-3B), even with R-CHOP therapy. [<I>J Clin Exp Hematop 53(2) : 121-125, 2013</I>]

    DOI： 10.3960/jslrt.53.121

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  • Upfront Autologous Stem Cell Transplantation for Untreated High-Risk Diffuse Large B-Cell Lymphoma in Patients Up to 60 Years of Age 査読

    Hirotaka Takasaki, Chizuko Hashimoto, Atsuko Fujita, Kenji Matsumoto, Jun Taguchi, Hideyuki Kuwabara, Etsuko Yamazaki, Hideyuki Koharazawa, Hiroyuki Fujita, Shin Fujisawa, Yoshimi Ishii, Wataru Yamamoto, Shigeki Motomura, Naoto Tomita, Yoshiaki Ishigatsubo, Rika Sakai

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   13 ( 4 )   404 - 409   2013年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.clml.2013.03.003

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  • Cord colitis syndromeを合併した急性骨髄性白血病

    田中 正嗣, 桑原 英幸, 立花 崇孝, 本橋 賢治, 中嶋 ゆき, 沼田 歩, 岸本 久美子, 藤澤 信, 大島 理加, 石ヶ坪 良明

    神奈川医学会雑誌   40 ( 2 )   319 - 319   2013年7月

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    記述言語：日本語   出版者・発行元：(公社)神奈川県医師会  

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  • R-CHOP therapy alone in limited stage diffuse large B-cell lymphoma. 国際誌

    Naoto Tomita, Hirotaka Takasaki, Kazuho Miyashita, Shin Fujisawa, Eriko Ogusa, Shiro Matsuura, Kumiko Kishimoto, Ayumi Numata, Atsuko Fujita, Rika Ohshima, Hideyuki Kuwabara, Maki Hagihara, Chizuko Hashimoto, Sachiya Takemura, Hideyuki Koharazawa, Etsuko Yamazaki, Katsumichi Fujimaki, Jun Taguchi, Rika Sakai, Yoshiaki Ishigatsubo

    British journal of haematology   161 ( 3 )   383 - 8   2013年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Long-term observation has identified a pattern of continuing relapse in limited stage diffuse large B-cell lymphoma (DLBCL) treated by three cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) plus involved-field irradiation. We retrospectively analysed 190 untreated patients with limited stage DLBCL treated by R-CHOP alone. All the patients were scheduled to undergo primary therapy with six cycles of full-dose R-CHOP. Cases with a dose reduction of more than 20% were excluded from the study. Additional local irradiation was allowed in patients with partial response (PR). Five patients received additional local irradiation after PR at the end of the R-CHOP therapy. The median observation period was 52 months. Median age at diagnosis was 63 years. The responses to therapy were 180 complete responses, eight PR, and two progression of disease (PD). The 5-year progression-free survival and 5-year overall survival rates were 84% and 90%, respectively, both in plateau. During the observation period, 29 patients experienced PD. The progression sites were the primary sites in 15 patients, outside the primary sites in 10, and undetermined in four patients. These results suggest that the 'standard' strategy of three cycles of R-CHOP followed by involved-field radiotherapy for limited stage DLBCL could be effectively replaced by six cycles of R-CHOP alone.

    DOI： 10.1111/bjh.12281

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  • Phase 2 study of arsenic trioxide followed by autologous hematopoietic cell transplantation for relapsed acute promyelocytic leukemia. 国際誌

    Masamitsu Yanada, Motohiro Tsuzuki, Hiroyuki Fujita, Katsumichi Fujimaki, Shin Fujisawa, Kazutaka Sunami, Masafumi Taniwaki, Akira Ohwada, Kosuke Tsuboi, Akio Maeda, Akihiro Takeshita, Shigeki Ohtake, Yasushi Miyazaki, Yoshiko Atsuta, Yukio Kobayashi, Tomoki Naoe, Nobuhiko Emi

    Blood   121 ( 16 )   3095 - 102   2013年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The optimal treatments for relapsed acute promyelocytic leukemia (APL) remain equivocal. We conducted a phase 2 study to evaluate the efficacy and feasibility of a sequential treatment consisting of induction and consolidation with arsenic trioxide (ATO), peripheral blood stem cell (PBSC) harvest after high-dose cytarabine chemotherapy, and autologous hematopoietic cell transplantation (HCT). Between 2005 and 2009, 35 patients (26 with hematologic and 9 with molecular relapse) were enrolled. Induction therapy resulted in complete remission in 81% of those with hematologic relapse, and most patients became negative for PML-RARα after the first ATO consolidation course, but 4 remained positive. Administration of the second ATO consolidation course further decreased the transcript levels in 3 patients. In total, 25 patients proceeded to PBSC harvest, all of whom successfully achieved the target CD34+ cell doses, and 23 underwent autologous HCT with PML-RARα-negative PBSC graft. Posttransplant relapse occurred in 3 patients, and there was no transplant-related mortality. With a median follow-up of 4.9 years, the 5-year event-free and overall survival rates were 65% and 77%, respectively. These findings demonstrate the outstanding efficacy and feasibility of the sequential treatment featuring ATO and autologous HCT for relapsed APL. This study was registered at http://www.umin.ac.jp/ctr/ as #C000000302.

    DOI： 10.1182/blood-2012-11-466862

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  • Prospective multicenter study of single-unit cord blood transplantation with myeloablative conditioning for adult patients with high-risk hematologic malignancies. 国際誌

    Takehiko Mori, Masatsugu Tanaka, Takeshi Kobayashi, Kazuteru Ohashi, Shin Fujisawa, Akira Yokota, Hiroyuki Fujita, Chiaki Nakaseko, Toru Sakura, Yasuhito Nannya, Satoshi Takahashi, Heiwa Kanamori, Yoshinobu Kanda, Hisashi Sakamaki, Shinichiro Okamoto

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   19 ( 3 )   486 - 91   2013年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Although the use of cord blood transplantation (CBT) is increasing, the optimal methods for conditioning and graft-versus-host disease (GVHD) prophylaxis remain to be established. Among previous reports, the Institute of Medical Science, University of Tokyo (IMSUT) has reported remarkably favorable results of CBT for hematologic malignancies as a single-institute experience. The aim of the present multicenter prospective study was to assess the safety and efficacy of CBT performed precisely according to IMSUT transplantation procedures. Thirty-three adult patients with hematologic malignancies, such as acute leukemia, chronic myelogenous leukemia, or myelodysplastic syndrome, either lacking an HLA-identical sibling/HLA-matched unrelated donor or requiring urgent transplantation were enrolled. Conditioning consisted of total body irradiation (12 Gy), cytarabine, and cyclophosphamide. Cyclosporine A and methotrexate were used for GVHD prophylaxis. Diagnoses were acute leukemia in 26 patients, chronic myelogenous leukemia in 4, and myelodysplastic syndrome in 3; 12 patients were in first complete remission, and the others were in advanced stages at the time of CBT. Thirty-one patients achieved engraftment, and the cumulative incidence of grade II-IV acute GVHD was 45% (95% confidence interval, 28%-62%). With a median follow-up of 46.2 months in 16 surviving patients, the 1-year cumulative incidence of nonrelapse mortality was 15% (95% confidence interval, 5%-30%). Causes of nonrelapse mortality were infection (n = 4) and graft failure (n = 1). The overall and disease-free survival rates were 51% (95% CI, 34%-68%) and 42% (95% CI, 26%-59%), respectively. These results suggest that the IMSUT CBT procedures can safely provide a high disease-free survival rate in patients with high-risk hematologic malignancies.

    DOI： 10.1016/j.bbmt.2012.12.007

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  • Successful disease control with L-asparaginase monotherapy for aggressive natural killer cell leukemia with severe hepatic failure. 国際誌

    Hiroyuki Takahashi, Rika Sakai, Yukako Hattori, Rika Ohshima, Hideyuki Kuwabara, Maki Hagihara, Makiko Enaka, Akinori Nozawa, Naoto Tomita, Yoshiaki Ishigatsubo, Shin Fujisawa

    Leukemia & lymphoma   54 ( 3 )   662 - 4   2013年3月

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  • Allogeneic hematopoietic stem cell transplantation for patients with mildly reduced renal function as defined based on creatinine clearance before transplantation. 国際誌

    Kumi Oshima, Yoshinobu Kanda, Yasuhito Nanya, Masatsugu Tanaka, Chiaki Nakaseko, Shingo Yano, Shin Fujisawa, Hiroyuki Fujita, Akira Yokota, Satoshi Takahashi, Heiwa Kanamori, Shinichiro Okamoto

    Annals of hematology   92 ( 2 )   255 - 60   2013年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    While renal comorbidity is generally defined by the serum creatinine level, the creatinine clearance rate (Ccr) is a more accurate indicator of renal function. Therefore, we retrospectively assessed how mildly reduced renal function as defined based on Ccr affects the outcome after allogeneic hematopoietic stem cell transplantation (HSCT). Patients who underwent allogeneic HSCT at the eight institutes of the Kanto Study Group for Cell Therapy were included in this study. Based on the corrected Ccr, patients were classified into group 0 (n = 440,  ≥ 90 mL/min/1.73 m(2)), group 1 (n = 56, 60-89 mL/min/1.73 m(2)), or group 2 (n = 11, 30-59 mL/min/1.73 m(2)). Therefore, 67 patients were considered to have mild renal impairment, whereas only 2 had a serum creatinine level higher than 1.2 mg/dL. Twenty-eight patients required hemodialysis after HSCT, with 5.5, 5.4, and 9.1 % in groups 0, 1, and 2, respectively (p = 0.65). The incidence of non-relapse mortality (NRM) was higher in group 2, although these differences were not statistically significant probably due to the small sample size (23.7, 28.2, and 47.2 % at 3 years, p = 0.20). In conclusion, NRM may be associated with mildly reduced renal function before allogeneic HSCT, which cannot be detected by measurement of the serum creatinine level alone.

    DOI： 10.1007/s00277-012-1584-1

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  • Twenty-eight cases of relapsed or refractory multiple myeloma treated with lenalidomide

    Yukako Hattori, Katsumichi Fujimaki, Yoshimi Ishii, Satomi Itoh, Rika Ohshima, Maki Hagihara, Kenji Matsumoto, Hideyuki Koharazawa, Chizuko Hashimoto, Rika Sakai, Hiroyuki Fujrra, Hiroshi Haran, Koji Ogawa, Naoto Tomita, Shin Fujisawa, Yoshiaki Ishigatsubo

    Yokohama Medical Journal   64 ( 2 )   39 - 43   2013年

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Medical Association of Yokohama City University  

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  • 移植前の寛解導入療法としてレナリドマイドと大量デキサメタゾンの併用療法を施行したPOEMS症候群

    松浦 史郎, 大草 恵理子, 田口 淳, 今井 昇, 藤田 浩之, 富田 直人, 石ヶ坪 良明, 藤澤 信

    臨床血液   53 ( 12 )   2025 - 2028   2012年12月

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    記述言語：日本語   出版者・発行元：The Japanese Society of Hematology  

    A 60-year-old male with POEMS syndrome received lenalidomide and high-dose dexamethasone combination therapy as an initial treatment, with no severe adverse events occurring during the treatment. Two cycles of the therapy led to significantly decreased serum VEGF level, and IgA-λ type M-protein was not detected by immunofixation electrophoresis. We next performed autologous stem cell transplantation, without severe complications such as engraftment syndrome. He improved enough to walk independently and now is being followed up without treatment. This case suggests that lenalidomide-dexamethasone therapy is highly effective and can be a good option for pre-transplant treatment for POEMS syndrome.

    DOI： 10.11406/rinketsu.53.2025

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  • Allogeneic hematopoietic stem cell transplantation for adult AML patients with granulocytic sarcoma 査読

    H. Shimizu, T. Saitoh, M. Tanaka, T. Mori, T. Sakura, N. Kawai, Y. Kanda, C. Nakaseko, S. Yano, H. Fujita, S. Fujisawa, S. Miyawaki, H. Kanamori, S. Okamoto

    LEUKEMIA   26 ( 12 )   2469 - 2473   2012年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/leu.2012.156

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  • SIL index, comprising stage, soluble interleukin-2 receptor, and lactate dehydrogenase, is a useful prognostic predictor in diffuse large B-cell lymphoma 査読

    Naoto Tomita, Rika Sakai, Shin Fujisawa, Katsumichi Fujimaki, Jun Taguchi, Chizuko Hashimoto, Koji Ogawa, Etsuko Yamazaki, Yoshiaki Ishigatsubo

    CANCER SCIENCE   103 ( 8 )   1518 - 1523   2012年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/j.1349-7006.2012.02331.x

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  • [Retrospective analysis of treatment outcomes in 70 patients with t(8;21) acute myeloid leukemia].

    Ayumi Numata, Katsumichi Fujimaki, Tomohiro Aoshima, Makoto Onizuka, Maki Hagihara, Koji Miyazaki, Hiroyuki Fujita, Rika Sakai, Shinichiro Machida, Eri Tanaka, Yuki Nakajima, Yukako Hattori, Masatsugu Tanaka, Etsuko Yamazaki, Yukari Shirasugi, Yasuyuki Inoue, Shigeki Watanabe, Shin Fujisawa

    [Rinsho ketsueki] The Japanese journal of clinical hematology   53 ( 7 )   698 - 704   2012年7月

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

    We conducted a retrospective study to evaluate outcomes and prognostic factors of newly diagnosed patients with t(8;21) acute myeloid leukemia (AML). There were 70 patients (43 men and 27 women) with a median age of 48 years old (range, 17∼76 years old). Sixty-five patients achieved complete remission (CR) after induction chemotherapy. Fifty-seven patients received consolidation chemotherapy based on the policy of not performing allogeneic hematopoietic stem cell transplantation (allo-HSCT) at the time of first CR. Twenty-seven of the 57 patients relapsed (relapse rate, 47%). The median time from the achievement of the first CR to relapse was 307 days (96∼1,256 days). A white blood cell count of more than 25,400/μl at diagnosis was associated with a higher relapse rate than a white blood cell count of less than or equal to 25,400/μl (75% vs. 43%, P=0.04). Nineteen of the 25 relapsed patients who received re-induction therapy experienced a second CR (second CR rate, 76%). Twenty-six patients (5 with first CR, 12 with second CR, and 9 without remission) received allo-HSCT. The five-year overall survival and disease-free survival rates were 61% and 45%, respectively. Patients with t(8;21) AML had a high CR rate, but about half of them relapsed. However, this report could not show prognostic factors for the identification of patients who should receive allo-HSCT at the time of their first CR.

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  • Long-term outcome following imatinib therapy for chronic myelogenous leukemia, with assessment of dosage and blood levels: the JALSG CML202 study 査読

    Kazunori Ohnishi, Chiaki Nakaseko, Jin Takeuchi, Shin Fujisawa, Tadashi Nagai, Hirohito Yamazaki, Tetsuzo Tauchi, Kiyotoshi Imai, Naoki Mori, Fumiharu Yagasaki, Yasuhiro Maeda, Noriko Usui, Yasushi Miyazaki, Koichi Miyamura, Hitoshi Kiyoi, Shigeki Ohtake, Tomoki Naoe

    CANCER SCIENCE   103 ( 6 )   1071 - 1078   2012年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/j.1349-7006.2012.02253.x

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  • Pretransplant serum ferritin has a prognostic influence on allogeneic transplant regardless of disease risk. 国際誌

    Takayoshi Tachibana, Masatsugu Tanaka, Ayumi Numata, Hirotaka Takasaki, Satomi Ito, Rika Ohshima, Maki Hagihara, Etsuko Yamazaki, Naoto Tomita, Katsumichi Fujimaki, Jun Taguchi, Rika Sakai, Hiroyuki Fujita, Shin Fujisawa, Atsuo Maruta, Yoshiaki Ishigatsubo, Heiwa Kanamori

    Leukemia & lymphoma   53 ( 3 )   456 - 61   2012年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A multicenter retrospective analysis of the influence of pretransplant serum ferritin (SF) was performed in 261 adult recipients of allogeneic hematopoietic stem cell transplant (allo-HSCT), including 159 patients with acute myeloid leukemia (AML), 66 with acute lymphoid leukemia (ALL) and 36 with myelodysplastic syndrome (MDS). Patients were divided into subgroups according to the pretransplant SF level [< 1000 ng/mL (low) vs. ≥ 1000 ng/mL (high)] and disease status at transplant. A high SF level was significantly associated with high disease risk (p = 0.041), but pretransplant SF and disease risk were independent significant prognostic factors for overall survival (OS), disease-free survival (DFS) and non-relapse mortality rate (NRM) on multivariate analysis. The high-SF group showed a worse outcome than the low-SF group among both standard-risk patients (OS: 54% vs. 64%, p = 0.043; DFS: 46% vs. 57%, p = 0.031) and high-risk patients (OS: 16% vs. 35%, p = 0.001; DFS: 15% vs. 34%, p = 0.001). In conclusion, a high SF at transplant adversely influences the outcome of allo-HSCT regardless of disease risk in patients with acute leukemia and MDS.

    DOI： 10.3109/10428194.2011.619607

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  • Clinical efficacy of carbapenems on hospital-acquired pneumonia in accordance with the Japanese Respiratory Society Guidelines for management of HAP 査読

    Masaru Ito, Takeshi Kaneko, Hideto Goto, Nobuhiro Yamaguchi, Shin Fujisawa, Shigeru Ono, Satoshi Morita, Naoki Miyazawa, Heiwa Kanamori, Yuji Watanuki, Yoshiaki Ishigatsubo

    JOURNAL OF INFECTION AND CHEMOTHERAPY   17 ( 6 )   770 - 775   2011年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s10156-011-0253-y

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  • Long-term outcome of human herpesvirus-6 encephalitis after allogeneic stem cell transplantation. 国際誌

    Rika Sakai, Heiwa Kanamori, Kenji Motohashi, Wataru Yamamoto, Shiro Matsuura, Atsuko Fujita, Rika Ohshima, Hideyuki Kuwabara, Masatsugu Tanaka, Hiroyuki Fujita, Atsuo Maruta, Yoshiaki Ishigatsubo, Shin Fujisawa

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   17 ( 9 )   1389 - 94   2011年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Human herpesvirus-6 (HHV-6) encephalitis is recognized as a relatively rare, but sometimes lethal, complication of allogeneic hematopoietic stem cell transplantation (HSCT). Although the development of new diagnostic techniques and antiviral therapy has improved, the prognosis of encephalitis is still unclear. We surveyed 197 patients who underwent allogeneic HSCT between January 2004 and March 2008 at our institution, and 8 (4.0%) were diagnosed as having HHV-6 encephalitis. Five were male and 3 were female, with a median age of 40.5 years. The median onset of HHV-6 encephalitis was 18 days after HSCT, and the median duration of antiviral therapy was 41 days. The median survival time from the onset of encephalitis was 23.1 months (range: 2.7-66.7), and 3 patients died of unrelated causes (sepsis in 2 and gastrointestinal tract bleeding in 1). Cord blood transplantation was identified as the only independent risk factor (relative risk [RR] = 4.98; P = .049) by multivariate analysis. There was no statistical significance of survival after HSCT between the patients with HHV-6 encephalitis and those without HHV-6 encephalitis (the 2-year survival rate was 60% and 52.6%, respectively; P = .617). Four of the 5 surviving patients were unable to return to society because of neuropsychological disorders, including anterograde amnesia and seizures with prominent hippocampal atrophy. Although HHV-6 encephalitis occurring after HSCT is now becoming a curable complication, its sequelae, such as neuropsychological disorders, have a marked influence on the quality of life of long-term survivors. Accordingly, it is necessary to identify risk factors for HHV-6 encephalitis and establish methods for prevention of this complication.

    DOI： 10.1016/j.bbmt.2011.01.014

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  • Lack of non-hematological cross intolerance of dasatinib to imatinib in imatinib-intolerant patients with Philadelphia chromosome positive chronic myeloid leukemia or acute lymphatic leukemia: a retrospective safety analysis 査読

    Yukio Kobayashi, Hisashi Sakamaki, Shin Fujisawa, Kiyoshi Ando, Kazuhito Yamamoto, Masaya Okada, Kenichi Ishizawa, Tadashi Nagai, Syuichi Miyawaki, Toshiko Motoji, Noriko Usui, Shinsuke Iida, Masafumi Taniwaki, Nobuhiko Uoshima, Taku Seriu, Ryuzo Ohno

    INTERNATIONAL JOURNAL OF HEMATOLOGY   93 ( 6 )   745 - 749   2011年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s12185-011-0864-1

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  • Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases: a multi-institutional study 査読

    Yasunori Nakagawa, Kenshi Suzuki, Takayuki Hirose, Takaaki Chou, Shin Fujisawa, Michiko Kida, Kensuke Usuki, Yoji Ishida, Shuichi Taniguchi, Yasuji Kouzai, Shigeru Tomoyasu, Koji Miyazaki, Masaaki Higashihara, Kiyoshi Ando, Sadao Aoki, Ayako Arai, Nobu Akiyama, Kiyohiko Hatake, Shinichiro Okamoto, Kazuo Dan, Kazuma Ohyashiki, Akio Urabe

    JOURNAL OF INFECTION AND CHEMOTHERAPY   17 ( 1 )   58 - 67   2011年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s10156-010-0075-3

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  • Assessment of adherence to imatinib therapy by questionnaire survey in patients with chronic myeloid leukemia

    Hideyuki Kuwabara, Hiroyuki Takahashi, Yukako Hattori, Rika Ohshima, Maki Hagihara, Rika Sakai, Tetsuji Kaneko, Satoshi Morita, Yoshiaki Ishigatsubo, Shin Fujisawa

    Yokohama Medical Journal   62 ( 4 )   495 - 500   2011年

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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  • Erratum: Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases: A multi-institutional study (Journal of Infection and Chemotherapy DOI: 10.1007/s10156-010-0075-3) 査読

    Yasunori Nakagawa, Kenshi Suzuki, Takayuki Hirose, Takaaki Chou, Shin Fujisawa, Michiko Kida, Kensuke Usuki, Yoji Ishida, Shuichi Taniguchi, Yasuji Kouzai, Shigeru Tomoyasu, Koji Miyazaki, Masaaki Higashihara, Kiyoshi Ando, Sadao Aoki, Ayako Arai, Nobu Akiyama, Kiyohiko Hatake, Shinichiro Okamoto, Kazuo Dan, Kazuma Ohyashiki, Akio Urabe

    Journal of Infection and Chemotherapy   17 ( 1 )   68 - 69   2011年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Society for Cancer Chemotherapy  

    DOI： 10.1007/s10156-010-0185-y

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  • L-asparaginase単剤で全身状態が改善し、SMILE療法、allo-SCTを施行しえたaggressive NK cell leukemiaの一例

    高橋 寛行, 酒井 リカ, 服部 友歌子, 大島 理加, 桑原 英幸, 萩原 真紀, 江中 牧子, 野沢 昭典, 石ヶ坪 良明, 藤澤 信

    臨床血液   51 ( 9 )   1254 - 1254   2010年9月

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    記述言語：日本語   出版者・発行元：(一社)日本血液学会-東京事務局  

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  • 別クローン由来と考えられるt(15;17)(q22;q12)とt(9;22)(q34;q11.2)を認めた急性前骨髄性白血病(APL)の1例

    高橋 寛行, 服部 友歌子, 大島 理加, 萩原 真紀, 桑原 英幸, 藤澤 信, 酒井 リカ, 石ヶ坪 良明

    臨床血液   51 ( 3 )   222 - 222   2010年3月

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    記述言語：日本語   出版者・発行元：(一社)日本血液学会-東京事務局  

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  • The therapeutic effect of rituximab on CD5-positive and CD5-negative diffuse large B-cell lymphoma 査読

    Rie Hyo, Naoto Tomita, Kengo Takeuchi, Tomohiro Aoshima, Atsuko Fujita, Hideyuki Kuwabara, Chizuko Hashimoto, Sachiya Takemura, Jun Taguchi, Rika Sakai, Hiroyuki Fujita, Shin Fujisawa, Koji Ogawa, Shigeki Motomura, Ritsuro Suzuki, Yoshiaki Ishigatsubo

    HEMATOLOGICAL ONCOLOGY   28 ( 1 )   27 - 32   2010年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/hon.896

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  • 抗HLAクラスII抗体陽性例に対する再臍帯血移植

    桑原 英幸, 高橋 寛行, 服部 友歌子, 山本 渉, 大島 理加, 萩原 真紀, 藤澤 信, 酒井 リカ, 石ヶ坪 良明

    神奈川医学会雑誌   37 ( 1 )   110 - 110   2010年1月

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    記述言語：日本語   出版者・発行元：(公社)神奈川県医師会  

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  • Retrospective comparison of mobilization methods for autologous stem cell transplantation in multiple myeloma 査読

    Hideki Nakasone, Yoshinobu Kanda, Tomoki Ueda, Kenji Matsumoto, Naomi Shimizu, Jiro Minami, Rika Sakai, Maki Hagihara, Akira Yokota, Kumi Oshima, Yuiko Tsukada, Takayoshi Tachibana, Chiaki Nakaseko, Shin Fujisawa, Shingo Yano, Hiroyuki Fujita, Satoshi Takahashi, Heiwa Kanamori, Shinichiro Okamoto

    AMERICAN JOURNAL OF HEMATOLOGY   84 ( 12 )   809 - 814   2009年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/ajh.21552

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  • 免疫電気泳動でM蛋白陰性だがVEGF高値で診断したPOEMS症候群

    服部 友歌子, 田口 淳, 松浦 史郎, 今井 昇, 和佐野 浩一郎, 小原澤 英之, 高橋 寛行, 大島 理加, 萩原 真紀, 桑原 英幸, 酒井 リカ, 藤澤 信, 石ヶ坪 良明

    臨床血液   50 ( 9 )   1159 - 1159   2009年9月

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    記述言語：日本語   出版者・発行元：(一社)日本血液学会-東京事務局  

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  • Features of primary extranodal lymphoma in Kanagawa, a human T-cell leukemia virus type 1 nonendemic area in Japan

    Atsuko Fujita, Naoto Tomita, Hiroyuki Fujita, Kenji Motohashi, Rie Hyo, Etsuko Yamazaki, Michiko Hattori, Shin Fujisawa, Heiwa Kanamori, Koji Ogawa, Shigeki Motomura, Fumio Kodama, Yoshiaki Ishigatsubo

    Medical Oncology   26 ( 1 )   49 - 54   2009年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s12032-008-9080-0

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  • Diffuse Large B Cell Lymphoma without Immunoglobulin Light Chain Restriction by Flow Cytometry 査読

    Naoto Tomita, Kengo Takeuchi, Rie Hyo, Chizuko Hashimoto, Sachiya Takemura, Jun Taguchi, Hiroyuki Fujita, Shin Fujisawa, Koji Ogawa, Shigeki Motomura, Yoshiaki Ishigatsubo

    ACTA HAEMATOLOGICA   121 ( 4 )   196 - 201   2009年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1159/000220332

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  • Long-Term Follow-up of the Randomized JALSG AML 201 Study Comparing High Dose Ara-C Therapy with Conventional Consolidation Therapy in Adult Acute Myeloid Leukemia (AML) 査読

    Shuichi Miyawaki, Shigeki Ohtake, Shin Fujisawa, Hitoshi Kiyoi, Katsuji Shinagawa, Noriko Usui, Kohichi Miyamura, Miki Nishimura, Yasushi Miyazaki, Kazuhiro Nishii, Tadashi Nagai, Takahisa Yamane, Masafumi Taniwaki, Masatomo Takahashi, Fumiharu Yagasaki, Yukihiko Kimura, Norio Asou, Sumihisa Honda, Kazunori Ohnishi, Tomoki Naoe, Ryuzo Ohno

    BLOOD   112 ( 11 )   56 - 56   2008年11月

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    記述言語：英語  

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  • Central nervous system relapse of leukemia after allogeneic hematopoietic stem cell transplantation 査読

    Kumi Oshima, Yoshinobu Kanda, Takuya Yamashita, Satoshi Takahashi, Takehiko Mori, Chiaki Nakaseko, Katsumichi Fujimaki, Akira Yokota, Shin Fujisawa, Takafumi Matsushima, Hiroyuki Fujita, Tohru Sakura, Shinichiro Okamoto, Atsuo Maruta, Hisashi Sakamaki

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   14 ( 10 )   1100 - 1107   2008年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.bbmt.2008.07.002

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  • サリドマイドが奏功し、自家末梢血幹細胞移植後に完全寛解を得た原発性形質細胞性白血病の1例

    酒井 リカ, 橋本 千寿子, 山崎 悦子, 青島 朋裕, 松浦 史郎, 山本 渉, 藤田 敦子, 大島 理加, 兵 理絵, 桑原 英幸, 石ヶ坪 良明, 藤澤 信

    臨床血液   49 ( 9 )   1134 - 1134   2008年9月

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  • 初診時ABO血液型がオモテ, ウラ不一致を示した急性骨髄性白血病

    藤田 敦子, 藤澤 信, 大島 理加, 兵 理絵, 桑原 英幸, 山崎 悦子, 富田 直人, 原野 浩, 石ヶ坪 良明

    臨床血液 = The Japanese Journal of Clinical Hematology   49 ( 1 )   51 - 54   2008年1月

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    記述言語：日本語   出版者・発行元：The Japanese Society of Hematology  

    A 42-year-old woman was admitted to our hospital with acute myelogenous leukemia. We conducted blood-type examination, and her serum showed strong agglutination with all B cells but questionable agglutination with A<sub>1</sub> cells, which became stronger with incubation. We considered her blood type as O, but her previously assessed blood type was A. After receiving one cycle of induction therapy, she achieved complete remission and blood group A antigen was proven on her red blood cells. Anti-A<sub>1</sub> in her serum disappeared after induction therapy. We should be aware that blood group antigens are not entirely independent of the environment and are occasionally modified by disease.

    DOI： 10.11406/rinketsu.49.51

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  • Usefulness of hematopoietic cell transplantation-specific comorbidity index after allogeneic hematopoietic stem cell transplantation

    Katsumichi Fujimaki, Rika Sakai, Shin Fujisawa, Hiroyuki Fujita, Masatsugu Tanaka, Maki Hagihara, Hideyuki Koharazawa, Takuya Miyazaki, Naoto Tomita, Heiwa Kanamori, Atsuo Maruta, Yoshiaki Ishigatsubo

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   35 ( 1 )   87 - 91   2008年

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  • Thiotepa/cyclophosphamide/TBI as a Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients Aged 50 Years and Over

    Fujimaki Katsumichi, Tanaka Masatsugu, Takasaki Hirotaka, Hyo Rie, Kawano Tomoko, Sakai Rika, Fujita Hiroyuki, Fujisawa Shin, Kanamori Heiwa, Maruta Atsuo, Ishigatsubo Yoshiaki

    Internal Medicine   47 ( 5 )   379 - 383   2008年

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    記述言語：英語   出版者・発行元：The Japanese Society of Internal Medicine  

    <b>Objective</b> To reduce the relapse rate for hematological malignancies after allogeneic hematopoietic stem cell transplantation, we employed a myeloablative regimen comprising thiotepa 400 mg/m<sup>2</sup>, cyclophosphamide 3,600 mg/m<sup>2</sup> and total body irradiation 10 Gy.<br> <b>Materials and Methods</b> Subjects comprised 17 patients (median age, 53 years; range, 50-56 years) with hematological malignancies who received allogeneic hematopoietic stem cell transplantation from HLA-identical related (n=6), HLA-mismatched family (n=2) or unrelated donors (n=9). Prophylaxis of acute graft-versus-host disease (GVHD) consisted of short-term methotrexate and cyclosporine (n=4) or short-term methotrexate and tacrolimus (n=13).<br> <b>Results</b> No grade IV regimen-related toxicities as determined by Bearman's criteria were encountered. Acute grade II-IV GVHD developed in 7 patients, with chronic GVHD in 11 patients. With a median follow-up of 39 months, 3 years survival rate after transplantation was 59%. Two patients died due to infection by 100 days after transplantation. Only 1 patient with Philadelphia-positive acute lymphoblastic leukemia experienced relapse. Eight patients died of non-leukemic causes (sepsis, n=2; liver dysfunction, n=2; idiopathic interstitial pneumonia, n=1; bacterial pneumonia, n=1; bronchiolitis obliterans resulting from chronic GVHD, n=1; and disseminated infection with varicella zoster virus, n=1).<br> <b>Conclusions</b> This regimen was tolerable, but a large trial is warranted to confirm the efficacy of this conditioning.<br>

    DOI： 10.2169/internalmedicine.47.0598

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  • Long-term outcome of L86 and L97 protocols for adult acute lymphoblastic leukemia 査読

    Hideyuki Koharazawa, Heiwa Kanamori, Rika Sakai, Chizuko Hashimoto, Sachiya Takemura, Etsuko Yamazaki, Michiko Hattori, Jun Taguchi, Katsumichi Fujimaki, Naoto Tomita, Hiroyuki Fujita, Shin Fujisawa, Hiroshi Harano, Koji Ogawa, Shigeki Motomura, Atsuo Maruta, Yoshiaki Ishigatsubo

    LEUKEMIA & LYMPHOMA   49 ( 11 )   2133 - 2140   2008年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1080/10428190802464711

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  • ダサチニブの慢性骨髄性白血病及びPhiladelphia染色体陽性急性リンパ性白血病に対する臨床第I/II相試験 査読

    坂巻 壽, 谷脇 雅史, 石澤 賢一, 藤澤 信, 森島 泰雄, 飛内 賢正, 岡田 昌也, 安藤 潔, 薄井 紀子, 宮脇 修一, 宇都宮 與, 魚嶋 伸彦, 永井 正, 直江 知樹, 泉二 登志子, 陣内 逸郎, 谷本 光音, 宮崎 泰司, 大西 一功, 飯田 真介, 岡本 真一郎, 芹生 卓, 大野 竜三

    臨床血液   48 ( 9 )   944 - 944   2007年9月

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    記述言語：日本語   出版者・発行元：(一社)日本血液学会-東京事務局  

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  • Comparison of peripheral T-cell lymphomas and diffuse large B-cell lymphoma 査読

    Naoto Tomita, Shigeki Motomura, Rie Hyo, Hirotaka Takasaki, Sachiya Takemura, Jun Taguchi, Shin Fujisawa, Koji Ogawa, Yoshiaki Ishigatsubo, Kengo Takeuchi

    CANCER   109 ( 6 )   1146 - 1151   2007年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/cncr.22507

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  • Postremission therapy in adult acute myeloid leukemia (AML): A randomized comparison between high dose ara-C therapy and conventional consolidation therapy (JALSG AML 201 study). 査読

    Shuichi Miyawaki, Shigeki Ohtake, Shin Fujisawa, Hitoshi Kiyoi, Katsuji Shinagawa, Noriko Usui, Koichi Miyamura, Miki Nishimura, Yasushi Miyazaki, Kazuhiro Nishii, Tadashi Nagai, Takahisa Yamane, Masafumi Taniwaki, Masatomo Takahashi, Fumiharu Yagasaki, Yukihiko Kimura, Norio Asou, Sumihisa Honda, Kazunori Ohnishi, Tomoki Naoe, Ryuzo Ohno

    BLOOD   108 ( 11 )   567A - 567A   2006年11月

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  • Phase II study of CHOP-GR therapy for advanced-stage follicular lymphoma 査読

    Naoto Tomita, Fumio Kodama, Rika Oshima, Chizuko Hashimoto, Hideyuki Koharazawa, Sachiya Takemura, Etsuko Yamazaki, Katsumichi Fujimaki, Rika Sakai, Hiroyuki Fujita, Shin Fujisawa, Heiwa Kanamori, Shigeki Motomura, Yoshiaki Ishigatsubo

    LEUKEMIA & LYMPHOMA   47 ( 6 )   1041 - 1047   2006年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1080/10428190500472784

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  • DLBCLにおけるbulky massへの寛解後照射の意義

    富田 直人, 児玉 文雄, 本村 茂樹, 伊藤 仁美, 大島 理加, 兵 理絵, 河野 知子, 橋本 千寿子, 竹村 佐千哉, 山崎 悦子, 藤田 浩之, 藤澤 信, 小川 浩司, 金森 平和, 石ヶ坪 良明

    日本リンパ網内系学会会誌   46   102 - 102   2006年6月

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    記述言語：日本語   出版者・発行元：(一社)日本リンパ網内系学会  

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  • 生前に診断された intravascular large B-cell lymphoma 8例の臨床的検討

    大島 理加, 富田 直人, 本橋 賢治, 家田 敦子, 兵 理絵, 藤澤 信, 藤田 浩之, 酒井 リカ, 小原澤 英之, 桑原 英幸, 金森 平和, 石ヶ坪 良明

    臨床血液 = The Japanese Journal of Clinical Hematology   46 ( 6 )   453 - 457   2005年6月

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    記述言語：日本語   出版者・発行元：一般社団法人 日本血液学会  

    生前にintravascular large B-cell lymphoma (IVL)と診断された8例について臨床像および治療経過を検討した。年齢は54歳&sim;82歳（中央値67歳），主訴は発熱，呼吸困難などであった。全例IV B期であり，performance status 4を4例に認めた。診断根拠となった生検部位は骨髄4例，肺2例，筋，副腎，リンパ節が各1例であり，初発時に6例で骨髄浸潤を認めた。7例で治療が行われ，そのうち5例でRituximabが化学療法に併用された。観察期間中央値12.3ヵ月の時点で5例が生存しているが，無病生存は1例のみであった。Rituximabを使用した5例中4例は再発している。IVLの早期診断のためにはまず積極的にIVLを疑うことが重要であり，特に骨髄生検の有用性が示唆された。Rituximabは一時的には有効であったが，長期的な効果は不十分であると考えた。

    DOI： 10.11406/rinketsu.46.453

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    その他リンク： http://search.jamas.or.jp/link/ui/2005290296

  • 中高および高リスク非ホジキンリンパ腫に対する末梢血幹細胞移植併用大量化学療法の試み

    本村 茂樹, 橋本 千寿子, 児玉 文雄, 丸田 壱郎, 酒井 リカ, 藤田 浩之, 富田 直人, 藤澤 信, 原野 浩, 小原澤 英之, 藤巻 克通, 金森 平和, 石ヶ坪 良明

    臨床血液 = The Japanese Journal of Clinical Hematology   46 ( 5 )   350 - 357   2005年5月

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    記述言語：日本語   出版者・発行元：一般社団法人 日本血液学会  

    中高および高リスク非ホジキンリンパ腫に対し初診時より自家末梢血幹細胞移植併用大量化学療法を目指した治療を行い，その成績を検討した。症例は1998年11月から2002年10月までに受診し，同意を得た28例である。治療はCHOP-V療法を2ないし3サイクル施行後，cyclophosphamide, methotrexate, etoposide各単剤大量療法を行い，最後にranimustine, ifosphamide, etoposideによる大量化学療法を施行後移植した。bulky massを持つ症例にはIF照射を行った。移植後の成績は完全寛解16例 (57%),部分寛解9例 (32%),奏効率は89%であった。照射後の総合効果は完全寛解20例 (71%), 部分寛解5例 (18%)であった。初期治療としてCHOP-V療法2サイクルを行った症例の30カ月における累積生存率56%に対し3サイクル群では82%であり，初期治療による腫瘍の縮小が重要であった。また，全例の30カ月におけるprogression-free survivalは64%, overall survivalは74%であり，IPIにおける60歳以下のhigh-intermediateおよびhighリスク群の治療成績より良好であった。

    DOI： 10.11406/rinketsu.46.350

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    その他リンク： http://search.jamas.or.jp/link/ui/2005235625

  • Epstein - Barr virus-associated extranodal NK/T-cell lymphoma following mosquito bites in an elderly patient without prior hypersensitivity

    Naoto Tomita, Heiwa Kanamori, Katsumichi Fujimaki, Shin Fujisawa, Yoshiaki Ishigatsubo

    Leukemia and Lymphoma   45 ( 10 )   2153 - 2155   2004年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1080/10428190410001697403

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  • Pulmonary embolism and thrombotic thrombocytopenic purpura in acute promyelocytic leukemia treated with all-trans retinoic acid

    Hiroyuki Fujita, Sachiya Takemura, Rie Hyo, Masatsugu Tanaka, Hideyuki Koharazawa, Shin Fujisawa, Heiwa Kanamori, Yoshiaki Ishigatsubo

    Leukemia and Lymphoma   44 ( 9 )   1627 - 1629   2003年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1080/1042819031000097401

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  • 単独の皮下腫瘤で発症したlymphoblastic lymphoma

    小島 実緒, 富田 直人, 藤巻 克通, 藤沢 信, 金森 平和, 石ヶ坪 良明

    臨床血液   44 ( 1 )   25 - 27   2003年1月

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    記述言語：日本語   出版者・発行元：一般社団法人 日本血液学会  

    A solitary cutaneous or subcutaneous mass in lymphoblastic lymphoma (LBL) is a rare manifestation. A 15-year-old girl presented with a subcutaneous LBL on her left back. There were no other lesions. Complete remission (CR) was achieved after 2 courses of ACOMP-B (doxorubicin, cyclophosphamide, vincristine, methotrexate, prednisolone, and bleomycin) therapy. Two courses of the chemotherapy and 4 sessions of prophylactic intrathecal methotrexate (15 mg/body) and hydrocortisone (25 mg/body) were added after CR. However, the patient relapsed with bone marrow involvement after 14 months remission. It is necessary to accumulate more experience with this kind of case to find the appropriate treatment strategy for solitary cutaneous or subcutaneous LBL.

    DOI： 10.11406/rinketsu.44.25

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    その他リンク： http://search.jamas.or.jp/link/ui/2003168393

  • 非血縁者間移植後の急性転化期再発例に対しドナーリンパ球輸注療法を施行しcomplete cytogenetic responseが得られた慢性骨髄性白血病

    藤巻 克通, 丸田 壱郎, 吉田 道彦, 山崎 悦子, 松崎 道男, 藤沢 信, 金森 平和, 石ヶ坪 良明

    臨床血液   42 ( 3 )   204 - 208   2001年3月

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    記述言語：日本語   出版者・発行元：The Japanese Society of Hematology  

    35歳，男性。1996年1月に慢性骨髄性白血病慢性期と診断後hydroxyureaを内服するも，1998年4月に急性転化となった。3コースの化学療法後，1998年10月にHLA-A, DRB 1の2座遺伝子型不一致ドナーより非血縁者間骨髄移植を施行した。移植後53日にはRT-PCRでMajor <i>bcr-abl</i>陰性化したが349日に急性転化再発した。1コースの化学療法後インターフェロン療法を施行し，2000年2月に同じ非血縁者ドナーから有核細胞数1.3×10<sup>7</sup>/kg（CD3+細胞：1.0×10<sup>7</sup>/kg）のドナーリンパ球輸注療法(donor lymphocyte infusion, DLI)を施行した。DLI後21日にcomplete cytogenetic responseが得られた。DLI後25日に急性移植片対宿主病grade IIIとなるが，プレドニン2 mg/kgの投与で軽快した。しかし，DLI後162日に髄外再発し化学療法後に敗血症を来たして死亡した。本例は急性移植片対宿主病を発症したものの血縁ドナーからのDLIは効果不良とされる慢性骨髄性白血病急性転化例に対し良好なgraft-versus-leukemia効果が得られた。

    DOI： 10.11406/rinketsu.42.204

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    その他リンク： https://jlc.jst.go.jp/DN/JALC/00090873287?from=CiNii

  • Subcutaneous Extramedullar Hematopoiesis in a Patient with Secondary Myelofibrosis Following Polycythemia Vera

    Masatsugu Tanaka, Heiwa Kanamori, Satoshi Yamaji, Aki Mishima, Etsuko Yamazaki, Jun Taguchi, Mami Aoba, Shin Fujisawa, Hiroshimohri, Yoshiaki Ishigatsubo

    Leukemia and Lymphoma   40 ( 42067 )   437 - 440   2001年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.3109/10428190109057946

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  • 硬膜下血腫, 急性硬膜外血腫から救命し得た急性前骨髄球性白血病の1例

    山路 聡, 金森 平和, 田中 政嗣, 三嶋 亜紀, 小原沢 英之, 藤田 浩之, 藤沢 信, 村田 興, 松崎 道男, 毛利 博, 石ヶ坪 良明

    臨床血液   40 ( 7 )   606 - 609   1999年7月

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    記述言語：日本語   出版者・発行元：The Japanese Society of Hematology  

    A 22-year-old woman was admitted with purpura. Acute promyelocytic leukemia (APL) with disseminated intravascular coagulation (DIC) was diagnosed. On the 17th day after treatment with all-<i>trans</i> retinoic acid (ATRA), left subdural hematoma developed. Although coagulation abnormalities were still observed, emergency surgery was perfomed. Acute epidural hematoma was confirmed by computed tomographic scan after the operation. A second operation for drainage was successful. Post-operative intracranial hematoma may be caused by rapid decompression induced by surgery, but DIC could also be involved. This case underscored the need for careful consideration of the indications for surgical treatment of such DIC patients, with close follow-up monitoring for the postoperative development of neurological symptoms.

    DOI： 10.11406/rinketsu.40.606

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    その他リンク： http://search.jamas.or.jp/link/ui/2000020558

  • De novo Acute Myelogenous Leukemia with Trilineage Myelodysplasia Associated with t(8:21)(q22;q22)

    Fujisawa Shin, Togawa Jun-ichi, Tanaka Masatsugu, KOHARAZAWA Hideyuki, AOBA Mami, FUJITA Hiroyuki, MURATA Takashi, KANAMORI Heiwa, MATSUZAKI Michio, MOHRI Hiroshi, ISHIGATSUBO Yoshiaki

    Internal medicine   38 ( 7 )   607 - 611   1999年7月

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    記述言語：英語   出版者・発行元：The Japanese Society of Internal Medicine  

    We describe a rare case of de novo acute myelogenous leukemia with trilineage myelodysplasia (AML/TMDS) associated with t(8;21)(q22;q22). The patient was admitted to our hospital with leukocytopenia. AML/TMDS was diagnosed by excess myeloblasts and morphological findings of bone marrow. The karyotype revealed 45, X, -Y, t(8;21)(q22;q22) in 17 of 20 analyzed mitoses, and also AML1/MTG8 transcripts were detected by the reverse transcription polymerase chain reaction (RT-PCR) method. The patient achieved a complete remission with a combination chemotherapy of daunorubicin, cytarabine, and prednisolone. This case suggests that t(8;21)(q22;q22) may participate in the pathogenesis of AML/TMDS, although this type is usually found as one of the chromosomal abnormalities in de novo acute myelogenous leukemia (AML) with maturation.<br>(Internal Medicine 38: 607-611, 1999)

    DOI： 10.2169/internalmedicine.38.607

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    その他リンク： https://jlc.jst.go.jp/DN/JALC/00086400046?from=CiNii

  • Improvement of quality of life after splenectomy in an HTLV-I carrier with T-cell prolymphocytic leukemia

    Rika Sakai, Atsuo Maruta, Naoto Tomita, Jun Taguchi, Shin Fujisawa, Koji Ogawa, Shigeki Motomura, Fumio Kodama, Hiroshi Mohri, Yoshiaki Ishigatsubo

    Leukemia and Lymphoma   35 ( 5-6 )   607 - 611   1999年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Harwood Academic Publishers GmbH  

    DOI： 10.1080/10428199909169626

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  • α-interferonとhydroxyureaにより長期にわたり骨髄低形成をきたした慢性骨髄性白血病

    本村 茂樹, 酒井 リカ, 富田 直人, 藤巻 克通, 服部 美智子, 藤沢 信, 毛利 博, 高橋 直樹, 丸田 壱郎, 児玉 文雄, 大久保 隆男

    臨床血液   39 ( 4 )   302 - 307   1998年4月

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    記述言語：日本語   出版者・発行元：一般社団法人 日本血液学会  

    症例は48歳，女性。慢性骨髄性白血病にて平成8年11月に受診した。白血球数は404,000/&mu;<i>l</i>あり，外来にてhydroxyurea (HU)による治療を開始した。平成9年1月29日より&alpha;-interferon (IFN&alpha;) 600万単位，連日投与へ変更したが，6日間で白血球が19,600/&mu;<i>l</i>から56,800/&mu;<i>l</i>へ増加したため，HU 2,000 mgを併用した。白血球数が10,000/&mu;<i>l</i>以下となったため，2月27日よりHUを500 mgへ減量し，4月4日よりIFN&alpha;を600万単位，週3回とした。5月から月経が再び始まり，貧血が進行した。また，同時に汎血球減少も進行した。骨髄生検では著明な低形成であり，Ph<sup>1</sup>染色体も残存していた。現在7カ月が経過したが，回復を認めていない。同様の報告は詳細の記載されたものが本例をふくめ9例あり，1例はIFN単独投与，8例が抗癌剤による前治療が行われていた。IFNによる免疫学的機序や抗癌剤との併用が原因と考えられるが，著明な骨髄低形成は致死的であり，今後，IFNを投与する際にはこのような副作用があることに注意する必要がある。

    DOI： 10.11406/rinketsu.39.302

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  • Therapy related leukemiaの臨床的検討

    藤沢 信, 丸田 壱郎, 酒井 リカ, 小川 浩司, 田口 淳, 富田 直人, 児玉 文雄, 府川 仁哉, 野口 太平, 松崎 道男, 本村 茂樹, 大久保 隆男

    臨床血液   36 ( 10 )   1163 - 1169   1995年10月

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    記述言語：日本語   出版者・発行元：The Japanese Society of Hematology  

    1983年10月より1994年12月までに神奈川県立がんセンター血液化学療法科において経験したTherapy related leukemia (TRL) 11例について検討した。男女比は6: 5で一次腫瘍診断時の年齢は14-75歳（中央値62歳）であった。一次腫瘍の内訳は乳癌3例，悪性リンパ腫2例で，胃癌・肺癌・膀胱癌・脳腫瘍・上顎洞癌・マクログロブリン血症が各1例であった。一次腫瘍に対して化学療法のみが7例，化学療法+放射線療法が4例であった。二次腫瘍は急性非リンパ性白血病が8例，急性リンパ性白血病が2例，低形成性白血病が1例であった。白血病診断時における一次腫瘍の状態は部分寛解の1例を除き10例が完全寛解であった。白血病に対し治療できなかった1例を除いた10例に治療が施され，その治療効果は3例に完全寛解が得られたのみで，白血病発症からの生存期間は7日-489日（中央値36日）と極めて不良であった。現在のところTRL発症の予防が重要であり，そのためには一次腫瘍に対して発癌作用の少ない薬剤を用いた治療法の検討が必要と考えられた。

    DOI： 10.11406/rinketsu.36.1163

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  • 骨髄移植後の剖検例におけるサイトメガロウイルス間質性肺炎に関する検討

    酒井 リカ, 丸田 壱郎, 田口 淳, 富田 直人, 児玉 文雄, 原田 昌興, 清水 昭男, 中村 圭靖, 飯田 萬一, 亀田 陽一, 本村 茂樹, 小川 浩司, 原野 浩, 藤沢 信, 松崎 道男, 大久保 隆男

    臨床血液   36 ( 8 )   735 - 741   1995年8月

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    記述言語：日本語   出版者・発行元：一般社団法人 日本血液学会  

    1985年5月&sim;1992年3月に施行した骨髄移植後の剖検例12例のホルマリン固定，パラフィン包埋された肺組織を用いて，H.E.染色，免疫染色，polymerase chain reaction (PCR)を行い，サイトメガロウイルス間質性肺炎(CMV-IP)について検討した。8例が臨床上間質性肺炎(IP)を合併し，うち3例は気管支肺胞洗浄液よりCMVが検出され，CMV-IPと診断された。剖検肺組織のH.E.染色では，臨床上のIP症例8例中2例は巨細胞封入体を認め，残る6例は線維化が主体であった。これら6例中4例は免疫染色法，あるいはPCR法にてCMVが証明された。また，臨床上CMV-IPと診断された3例は組織では巨細胞封入体を認めず，免疫染色法あるいはPCR法によりCMVが証明された。骨髄移植後のCMV-IPはH.E.染色のみでは診断困難な症例もあり，免疫染色法やPCR法によるCMVの検出が有用な場合があると考えられた。

    DOI： 10.11406/rinketsu.36.735

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    その他リンク： http://search.jamas.or.jp/link/ui/1996038504

  • Cyclosporin-A, G-CSF を併用した中等量ara-C, daunomycin 療法にて4度目の寛解に導入し得た急性前骨髄球性白血病

    本村 茂樹, 藤沢 信, 安斎 成一郎, 藤巻 克通, 服部 美智子, 府川 仁哉, 大久保 隆男

    臨床血液   36 ( 8 )   762 - 767   1995年8月

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    記述言語：日本語   出版者・発行元：一般社団法人 日本血液学会  

    症例は50歳，女性。急性前骨髄球性白血病にて昭和63年8月4日に受診した。寛解導入はdaunomycin連日BH-AC&middot;DMP療法が行われ，完全寛解となり，地固め療法としてBH-AC&middot;DM療法が2クール行われた。強化療法はBH-AC&middot;DM療法1回と中等量ara-C/mitoxantrone療法5回が年2回の割合で行われ，平成4年3月を最後に終了した。平成5年9月に再発し，ATRAにて寛解となった。平成6年5月に2度目の再発を起こし，G-CSF併用中等量ara-C/mitoxantrone療法にて寛解となったが，同年9月に3度目の再発となった。同意を得てG-CSF (300 &mu;g/body, day 1-7)でdormantな芽球を細胞回転に導入するよう試み，cyclosporin-A (8 mg/kg, day 2-5)で薬剤耐性克服を試み，daunomycin (45 mg/m<sup>2</sup>, day 3-5)とara-C (1.4 g/m<sup>2</sup>&times;2, day 3-7)による治療を行った。骨髄抑制が強く，寛解を認めるのに治療終了後46日かかった。cyclosporin-Aによる副作用は特に認めず，再発および難治性白血病患者には有効と思われた。

    DOI： 10.11406/rinketsu.36.762

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  • 初診時白血球の著しい増加を伴わず慢性骨髄性白血病と診断された2例

    白蓋 万葉子, 宮下 和甫, 畠山 まりか, 大橋 卓馬, 徳永 真由美, 青木 淳, 石井 好美, 中嶋 ゆき, 藤澤 信, 中島 秀明

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  • Association of Peripheral Regulatory T Cells with Achievement of Deep Molecular Response in Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia Treated with Dasatinib - the Final Results of D-First Study

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  • Phase III Randomized Study of Imatinib Therapy in Chronic Phase Chronic Myeloid Leukemia Comparing Standard Dose-Escalation with Progressive Dose-Escalation (JALSG CML207 study)

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  • 症例報告 第2回日本血液学会関東甲信越地方会 優秀演題 Dasatinib内服中に肺動脈性肺高血圧症を発症した慢性骨髄性白血病

    森下 さくら, 萩原 真紀, 板橋 めぐみ, 石井 好美, 山本 渉, 沼田 歩, 本橋 賢治, 松本 憲二, 藤澤 信, 中島 秀明

    臨床血液   57 ( 8 )   999 - 1003   2016年8月

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    記述言語：日本語   出版者・発行元：「臨床血液」編集部  

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  • Qualitative Analysis of Patient-Reported Free Comments on Quality of Life in Patients Who Completed Treatment for Acute Leukemia

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    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   22 ( 3 )   S454 - S455   2016年3月

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  • Musculoskeletal pain may be associated with imatinib withdrawal syndrome in chronic myeloid leukemia patients

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    LEUKEMIA & LYMPHOMA   57 ( 2 )   496 - 497   2016年2月

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    記述言語：英語   掲載種別：速報，短報，研究ノート等（学術雑誌）  

    DOI： 10.3109/10428194.2015.1064531

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  • Emergence of del(20q) in a patient in molecular remission of chronic myelogenous leukemia during imatinib treatment, with reduction following imatinib discontinuation

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    LEUKEMIA & LYMPHOMA   57 ( 1 )   201 - 202   2016年1月

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    記述言語：英語   掲載種別：速報，短報，研究ノート等（学術雑誌）  

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  • Body Mass Index Is a Prognostic Factor in Adults with Newly Diagnosed Acute Myeloid Leukemia: A Retrospective Multi-Institutional Study in Japan

    Taiki Ando, Etsuko Yamazaki, Haruka Teshigawara, Fujii Eriko, Yoshimi Ishii, Wataru Yamamoto, Kenji Motohashi, Takayoshi Tachibana, Maki Hagihara, Kenji Matsumoto, Masatsugu Tanaka, Hashimoto Chizuko, Koharazawa Hideyuki, Fujimaki Katsumichi, Jun Taguchi, Naoto Tomita, Hiroyuki Fujita, Heiwa Kanamori, Shin Fujisawa

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  • The Sil Index Is a Useful Prognostic Indicator for Diffuse Large B-Cell Lymphoma

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  • Prognostic Impact of Cytogenetic Abnormalities in Adult Patients with Philadelphia-Chromosome (Ph)-Negative Acute Lymphoblastic Leukemia (ALL) Who Underwent Allogeneic Stem Cell Transplant (allo-SCT)

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    BLOOD   126 ( 23 )   2015年12月

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  • Surveillance Imaging in Patients with Diffuse Large B-Cell Lymphoma

    Ayako Matsumura, Hideyuki Kuwabara, Kumiko Kishimoto, Eriko Fujii, Kazuho Miyashita, Hiroyuki Takahashi, Shiro Matsuura, Yuki Nakajima, Hirotaka Takasaki, Masatsugu Tanaka, Shin Fujisawa, Heiwa Kanamori, Motomura Shigeki, Naoto Tomita

    BLOOD   126 ( 23 )   2015年12月

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  • Effect of the order of TBI and cyclophosphamide administration on the outcome of allogeneic hematopoietic stem cell transplantation

    K. Motohashi, S. Fujisawa, M. Onizuka, S. Kako, E. Sakaida, K. Shono, R. Tatara, N. Doki, T. Mori, T. Sakura, N. Aotsuka, E. Fuji, N. Tomita, N. Kawai, T. Saitoh, K. Usuki, J. Taguchi, R. Watanabe, S. Kobayashi, S. Yano, H. Kanamori, S. Takahashi, S. Okamoto

    Bone Marrow Transplantation   50 ( 11 )   1476 - 1479   2015年11月

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    DOI： 10.1038/bmt.2015.142

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  • Evaluation of soluble interleukin-2 receptor and serum lactate dehydrogenase in malignant lymphoma

    Naoto Tomita, Masataka Taguri, Chizuko Hashimoto, Hirotaka Takasaki, Katsumichi Fujimaki, Shigeki Motomura, Hideyuki Koharazawa, Sachiya Takemura, Hiroyuki Fujita, Etsuko Yamazaki, Rika Kawasaki, Jun Taguchi, Rika Sakai, Shin Fujisawa, Yukako Hattori, Heiwa Kanamori, Wataru Yamamoto, Hiroshi Harano, Koji Ogawa, Yoshiaki Ishigatsubo

    ANNALS OF HEMATOLOGY   94 ( 11 )   1935 - 1937   2015年11月

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  • Favorable survival after allogeneic stem cell transplantation with reduced-intensity conditioning regimens for relapsed/refractory follicular lymphoma

    S. Yano, T. Mori, Y. Kanda, J. Kato, C. Nakaseko, S. Fujisawa, N. Tomita, R. Sakai, K. Shono, T. Saitoh, N. Aotsuka, N. Kobayashi, T. Saito, S. Takahashi, H. Kanamori, S. Okamoto

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  • Early cytotoxic lymphocyte expansion contributes to a deep molecular response to dasatinib in patients with newly diagnosed chronic myeloid leukemia in the chronic phase: results of the D-first study

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    AMERICAN JOURNAL OF HEMATOLOGY   90 ( 9 )   819 - 824   2015年9月

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  • R-CHOP therapy alone for limited-stage follicular lymphoma

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  • Biweekly THP-COP therapy for newly diagnosed peripheral T-cell lymphoma patients

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    Yoshimi Ishii, Naoto Tomita, Taisei Suzuki, Yasufumi Ishiyama, Kumiko Kishimoto, Eri Yamamoto, Satoshi Koyama, Yukako Hattori, Yuki Nakajima, Kenji Motohashi, Hirotaka Takasaki, Rika Kawasaki, Chizuko Hashimoto, Sachiya Takemura, Katsumichi Fujimaki, Hiroyuki Fujita, Rika Sakai, Shin Fujisawa, Shigeki Motomura, Yoshiaki Ishigatsubo

    LEUKEMIA & LYMPHOMA   56 ( 9 )   2750 - 2752   2015年

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  • Effect of High Body Mass Index on the Prognosis of Diffuse Large B-Cell Lymphoma

    Yukako Hattori, Naoto Tomita, Taisei Suzuki, Yasufumi Ishiyama, Kumiko Kishimoto, Satoshi Koyama, Hiroyuki Takahashi, Kazuho Miyashita, Yuki Nakajima, Kenji Motohashi, Hirotaka Takasaki, Rika Kawasaki, Chizuko Hashimoto, Katsumichi Fujimaki, Rika Sakai, Shin Fujisawa, Shigeki Motomura, Yoshiaki Ishigatsubo

    BLOOD   124 ( 21 )   2014年12月

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  • Effects of the Order of Administration of Total Body Irradiation and Cyclophosphamide on the Outcome of Allogeneic Hematopoietic Cell Transplantation

    Kenji Motohashi, Shin Fujisawa, Makoto Onizuka, Shinichi Kako, Emiko Sakaida, Katsumichi Shono, Raine Tatara, Noriko Doki, Takehiko Mori, Toru Sakura, Nobuyuki Aotsuka, Eriko Ogusa, Naoto Tomita, Nobutaka Kawai, Takayuki Saitoh, Kensuke Usuki, Jun Taguchi, Heiwa Kanamori, Satoshi Takahashi, Shinichiro Okamoto

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  • No Outcome Differences Were Observed Between Supra-Diaphragmatic and Infra-Diaphragmatic Lesions in Limited-Stage Diffuse Large B Cell Lymphoma Treated with R-CHOP Therapy, Whereas the Presence of Gastro-Intestinal Lesions Was Associated with a Favorable Prognosis

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    BLOOD   124 ( 21 )   2014年12月

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  • Imatinib-Based Chemotherapy for Newly Diagnosed BCRABL Positive Acute Lymphoblastic Leukemia: Japan Adult Leukemia Study Group (JALSG) Ph+ALL208 Study

    Shin Fujisawa, Keitaro Matsuo, Shuichi Mizuta, Hideki Akiyama, Yasunori Ueda, Yasutaka Aoyama, Yoshihiro Hatta, Kazuhiko Kakihana, Nobuaki Dobashi, Isamu Sugiura, Yasushi Onishi, Tomoya Maeda, Kiyotoshi Imai, Shigeki Ohtake, Yasushi Miyazaki, Kazunori Ohnishi, Tomoki Naoe

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  • Prognostic Impact of Gender in Diffuse Large B Cell Lymphoma Patients Treated with R-CHOP Therapy

    Hiroyuki Takahashi, Naoto Tomita, Yasufumi Ishiyama, Satoshi Koyama, Kazuho Miyashita, Yuki Nakajima, Yukako Hattori, Kenji Motohashi, Hirotaka Takasaki, Rika Kawasaki, Maki Hagihara, Chizuko Hashimoto, Sachiya Takemura, Katsumichi Fujimaki, Jun Taguchi, Rika Sakai, Hiroyuki Fujita, Shin Fujisawa, Hiroshi Harano, Yoshiaki Ishigatsubo

    BLOOD   124 ( 21 )   2014年12月

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  • Peripheral blood absolute lymphocyte/monocyte ratio as a useful prognostic factor in diffuse large B-cell lymphoma in the rituximab era

    Reina Watanabe, Naoto Tomita, Megumi Itabashi, Daisuke Ishibashi, Eri Yamamoto, Satoshi Koyama, Kazuho Miyashita, Hiroyuki Takahashi, Yuki Nakajima, Yukako Hattori, Kenji Motohashi, Hirotaka Takasaki, Rika Ohshima, Chizuko Hashimoto, Etsuko Yamazaki, Katsumichi Fujimaki, Rika Sakai, Shin Fujisawa, Shigeki Motomura, Yoshiaki Ishigatsubo

    EUROPEAN JOURNAL OF HAEMATOLOGY   92 ( 3 )   204 - 210   2014年3月

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  • Phase II Trial Of Medium-Dose VP-16, Cyclophosphamide and Total-Body Irradiation Conditioning Regimen Before Allogeneic Stem Cell Transplantation For Acute Lymphoblastic Leukemia In Adults

    Tatsunori Goto, Akio Shigematsu, Makoto Onizuka, Shin Fujisawa, Ritsuro Suzuki, Yoshiko Atsuta, Kazuo Hatanaka, Masayoshi Masuko, Toshiro Ito, Naoki Kobayashi, Jun Kato, Koichi Miyamura, Takahiro Fukuda, Yasuo Morishima, Masahiro Imamura

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  • Successful treatment of a pregnant woman with Philadelphia chromosome-positive acute lymphoblastic leukemia

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  • Absolute Monocyte Count in Follicular Lymphoma Patients Treated with Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone

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  • Does the Hematopoietic Cell Transplantation Specific Comorbidity Index (HCT-CI) Predict Transplant Outcomes?: A Prospective Multicenter Validation Study of the Kanto Study Group for Cell Therapy (KSGCT)

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  • Serum Ferritin Level As a Prognostic Factor for Patients with Extranodal NK/T-Cell Lymphoma, Nasal Type.

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  • Clinical Significance of Addition of Cytarabine or Thiotepa to TBI/CY Regimen.

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  • Retrospective Study of Standard R-CHOP Therapy in Localized DLBCL

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  • Clinical significance of minimal residual disease detected by multidimensional flow cytometry: Serial monitoring after allogeneic stem cell transplantation for acute leukemia 査読

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    LEUKEMIA RESEARCH   36 ( 8 )   998 - 1003   2012年8月

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  • Prognostic factors in patients aged 50 years or older undergoing allogeneic hematopoietic stem cell transplantation for hematologic malignancy

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  • Successful treatment with gemtuzumab ozogamicin and donor lymphocyte infusion for acute myeloid leukemia relapsing after allogeneic stem cell transplantation

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  • Allogeneic Hematopoietic Stem Cell Transplantation for Adult AML Patients with Granulocytic Sarcoma

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  • Standard R-CHOP Therapy in Follicular Lymphoma and Diffuse Large B-Cell Lymphoma

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  • Successful treatment with dasatinib and allogeneic peripheral blood stem cell transplant for imatinib-resistant Philadelphia chromosome-positive acute lymphoblastic leukemia relapsing after bone marrow transplant and donor lymphocyte infusion

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  • Pretransplant serum ferritin is associated with bloodstream infections within 100 days of allogeneic stem cell transplantation for myeloid malignancies

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  • ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR PATIENTS WITH LIGHT RENAL FAILURE

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  • A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: the JALSG AML201 Study

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  • Sustained Superior Long-Term Outcomes of Imatinib Therapy In Japanese Patients with Newly Diagnosed Chronic Myelogenous Leukemia In Chronic Phase: Sub-Analysis According to the Mean Daily Dose of Imatinib and the Plasma Trough Levels In JALSG CML202 Study After 66 Months Follow-up 査読

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  • Prophylactic impact of tyrosine kinase inhibitor administration after allogeneic stem cell transplantation on the incidence and severity of chronic graft-versus-host disease in patients with Philadelphia chromosome-positive leukaemia

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  • Phase 1/2 clinical study of dasatinib in Japanese patients with chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia

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  • Lower dose of imatinib provides outcomes similar to the standard dose imatinib in Japanese patients with early chronic-phase CML: The interim analyses of JALSG CML202 study

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  • Dasatinib (SPRYCEL (R), BMS-354825) phase-I/II study of patients with, chronic myeloid leukemia (CML) resistant or intolerant to imatinib: Results of the CA180031 study in Japan (Phase I portion).

    Hisashi Sakamaki, Shin Fujisawa, Kensei Tobinai, Masafumi Taniwaki, Shuichi Miyawaki, Itsuro Jinnai, Atae Utsunomiya, Mistune Tanimoto, Yasuo Morishima, Masaya Okada, Yasushi Miyazaki, Nobuhiko Uoshima, Taku Seriu

    BLOOD   108 ( 11 )   287B - 287B   2006年11月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）  

    Web of Science

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  • Outcome of Involved-Field Radiotherapy for Stage 1 Follicular Lymphoma

    TOMITA Naoto, KODAMA Fumio, MOTOHASHI Kenji, FUJITA Atsuko, HYO Rie, HASHIMOTO Chizuko, TAKEMURA Sachiya, YAMAZAKI Etsuko, TAGUCHI Jun, SAKAI Rika, FUJISAWA Shin, KANAMORI Heiwa, MOTOMURA Shigeki, ISHIGATSUBO Yoshiaki, TAKEUCHI Kengo

    International journal of hematology   83 ( 4 )   370 - 372   2006年5月

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    記述言語：英語  

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  • 60歳以上の造血器悪性腫瘍に対して施行した臍帯血移植の3例

    田野島 玲大, 本橋 賢治, 家田 敦子, 兵 理絵, 富田 直人, 藤澤 信, 石ヶ坪 良明, Reo TANOSHIMA, Kenji MOTOHASHI, Atsuko IEDA, Rie HYO, Naoto TOMITA, Shin FUJISAWA, Yoshiaki ISHIGATSUBO, 横浜市立大学附属市民総合医療センター 血液内科, 横浜市立大学附属市民総合医療センター 血液内科, 横浜市立大学附属市民総合医療センター 血液内科, 横浜市立大学附属市民総合医療センター 血液内科, 横浜市立大学附属市民総合医療センター 血液内科, 横浜市立大学附属市民総合医療センター 血液内科, 横浜市立大学大学院医学研究科 病態免疫制御内科学, Department of Hematology Yokohama City University Medical Center, Department of Hematology Yokohama City University Medical Center, Department of Hematology Yokohama City University Medical Center, Department of Hematology Yokohama City University Medical Center, Department of Hematology Yokohama City University Medical Center, Department of Hematology Yokohama City University Medical Center, Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine

    横濱醫學 = The Yokohama medical journal   56 ( 3 )   201 - 207   2005年5月

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    記述言語：日本語   出版者・発行元：横浜市立大学医学会  

    (症例1)68歳男性.2002年12月に発症したmantle cell lymphoma,clinical stage III A.CHOP療法,rituximab-CHOP療法により完全寛解となった.治療中に直腸癌が認められたため手術を施行した.その後頚部再発をきたし,化学療法,放射線局所照射を行ったが寛解には到らず,2004年4月に,膀帯血移植を施行した.Day19に生着,day28に完全キメラを確認した.Day44に頚部再発を認め,FK506中止し,腫瘍は縮小となったが再び増大し,化学療法を施行中である.(症例2)62歳男性.2002年7月に発症した.myelodysplastic syndrome (MDS) refractory anemia with excess of blasts(RAEB).Acute myeloblastic leukemia(AML)への進展を認めたため2004年5月に膀帯血移植を施行した.Day31に生着,day28に完全キメラを確認した.現在完全寛解を維持している.(症例3)60歳女性.2004年6月に発症したMDS(RAEB in transformation).早々にAMLへ移行したため,PS1で2004年8月に臍帯血移植を施行した.Day78に生着,day28に完全キメラを確認した.Day61に皮膚stage3・grade IIのacute graft versus host diseaseが出現したが,predonisolone 0.5mg/kg開始し速やかに消退した.現在完全寛解を維持している.最近施行されるようになってきた高齢者に対する造血幹細胞移植は,患者の高齢化に伴い健常な同胞ドナー候補を探すことが困難であり,また病勢によっては骨髄バンクからドナー候補を探す時間的な余裕がないことなどが問題となっている.一方,膀帯血移植は当初は小児領域で施行されていたが,最近では主に成人に対して施行されるようになっている.今回60歳以上の高齢者の造血器悪性腫瘍3例に対して臍帯血移植を施行し,その経過,合併症について検討した.高齢者の造血器悪性腫瘍に対して移植を考慮する場合に同胞に適するドナーがいない場合,非血縁骨髄移植のみならず,今後は臍帯血移植も選択肢の一つとして考慮し得るということが示された.Allogenic stem cell transplantation is now done not only for younger but also for elderly patients. It is very difficult for elderly patients to find healthy, suitable related donors, and in many cases there is not enough time to find unrelated bone marrow donors due to disease status. Cord blood transplantation was originally done for pediatric patients, but is now done for more adult patients than pediatric patients. We performed cord blood transplantation for 3 patients over 60 years old with hematological malignancies. We report their clinical courses and complications. If there are no suitable related donors for elderly patients, it is possible to choose not only unrelated bone marrow transplantation, but also cord blood transplantation.

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    その他リンク： http://id.nii.ac.jp/1246/00000864/

  • Clinical Significance of Fragmented Red Cells after Allogeneic Bone Marrow Transplantation

    KANAMORI Heiwa, TAKAISHI Yumiko, TAKABAYASHI Maki, TANAKA Masatsugu, YAMAJI Satoshi, TOMITA Naoto, FUJIMAKI Katsumichi, FUJISAWA Shin, WATANABE Shinichiro, MATSUZAKI Michio, ISHIGATSUBO Yoshiaki

    International journal of hematology   77 ( 2 )   180 - 184   2003年2月

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    記述言語：英語  

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  • Acute Lymphoblastic Leukemia with t(1;9;22)(q32;q34;q11)

    FUJISAWA Shin, KANAMORI Heiwa, TAKABAYASHI Maki, TANAKA Masatsugu, YAMAJI Satoshi, TOMITA Naoto, FUJIMAKI Katsumichi, ISHIGATSUBO Yoshiaki

    International journal of hematology   75 ( 4 )   443 - 445   2002年5月

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    記述言語：英語  

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  • Posttransplantation Epstein-Barr Viral Meningitis in a Patient With Chronic Myelogenous Leukemia

    KANAMORI Heiwa, FUJISAWA Shin, YAMAJI Satoshi, TANAKA Masatsugu, TOMITA Naoto, FUJIMAKI Katsumichi, ISHIGATSUBO Yoshiaki

    International journal of hematology   74 ( 4 )   473 - 474   2001年12月

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  • GVL効果の強化を目的とした同種骨髄移植におけるcyclosporineの早期減量,中止の妥当性の検討

    藤巻 克通, 藤沢 信, 青墳 信之, 斉藤 憲治, 金森 平和, 松崎 道男, 高橋 聡, 岡本 真一郎, 坂巻 壽, 丸田 壱郎

    臨床血液   42 ( 9 )   680 - 684   2001年9月

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    記述言語：日本語   出版者・発行元：日本臨床血液学会  

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    その他リンク： http://search.jamas.or.jp/link/ui/2002079447

  • 非血縁者間骨髄移植後の拒絶に対してHLA不一致非血縁ドナーからの再移植が奏効した慢性骨髄性白血病

    田中 正嗣, 金森 平和, 桑原 英幸, 山路 聡, 上條 亜紀, 田口 淳, 藤田 浩之, 藤沢 信, 松崎 道男, 毛利 博, 石ヶ坪 良明

    臨床血液   42 ( 8 )   656 - 658   2001年8月

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    記述言語：日本語   出版者・発行元：日本臨床血液学会  

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    その他リンク： http://search.jamas.or.jp/link/ui/2002043811

  • p210/p190 - bcr - abl double positive 急性リンパ性白血病の同種骨髄移植例における RT - PCR による p210 および p190 bcr - abl の経時的観察

    藤巻 克通, 丸田 壱郎, 吉田 道彦, 山崎 悦子, 本村 茂樹, 児玉 文雄, 松崎 道男, 藤沢 信, 金森 平和, 石ヶ坪 良明

    臨床血液   42 ( 2 )   89 - 93   2001年2月

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  • 慢性骨髄性白血病の同種骨髄移植後の Residual BCR-ABL Transcripts の追跡とその臨床背景についての検討

    小原澤 英之, 丸田 壱郎, 田辺 寿一, 岡本 直幸, 藤田 浩之, 藤沢 信, 金森 平和, 本村 茂樹, 毛利 博, 石坪 良明

    移植   35 ( 2 )   65 - 74   2000年4月

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  • Identification of breakpoint cluster regions at 1p36.3 and 3q21 in hematologic malignancies with t(1;3)(p36;q21)

    Seiichi Shimizu, Kazumi Suzukawa, Takao Kodera, Toshiro Nagasawa, Tsukasa Abe, Masafumi Taniwaki, Fumiharu Yagasaki, Hideo Tanaka, Shin Fujisawa, Bertil Johansson, Tomas Ahlgren, Jun Yokota, Kazuhiro Morishita

    Genes Chromosomes and Cancer   27 ( 3 )   229 - 238   2000年3月

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  • 同種造血幹細胞移植後の呼吸機能の検討

    藤巻 克通, 丸田 壱郎, 田辺 寿一, 橋本 千寿子, 児玉 文雄, 野村 郁男, 松崎 道男, 藤沢 信, 金森 平和, 本村 茂樹, 石ヶ坪 良明

    臨床血液   40 ( 12 )   1245 - 1251   1999年12月

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    記述言語：日本語   出版者・発行元：日本臨床血液学会  

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    その他リンク： http://search.jamas.or.jp/link/ui/2000132661

  • Chronic myelocytic leukemia following ulcerative colitis

    FUJISAWA Shin, MOTOMURA Shigeki, FUJIMAKI Katsumichi, MOHRI Hiroshi, OKUBO Takao

    International journal of hematology   63 ( 3 )   241 - 242   1996年4月

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  • 低悪性度非Hodgkinリンパ腫の強力化学療法

    服部 美智子, 本村 茂樹, 富田 直人, 田口 淳, 田辺 寿一, 酒井 リカ, 藤沢 信, 府川 仁哉, 金森 平和, 毛利 博, 丸田 壱郎, 児玉 文雄, 大久 保隆男

    臨床血液   37 ( 2 )   101 - 108   1996年2月

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    記述言語：日本語   出版者・発行元：日本臨床血液学会  

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    その他リンク： http://search.jamas.or.jp/link/ui/1996185851

  • 骨髄移植後のサイトメガロウイルス間質性肺炎に対するganciclovir の予防投与

    酒井 リカ, 丸田 壱郎, 田口 淳, 富田 直人, 藤田 浩之, 児玉 文雄, 小川 浩司, 藤沢 信, 松崎 道男, 本村 茂樹, 大久保 隆男

    臨床血液   37 ( 1 )   14 - 21   1996年1月

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    記述言語：日本語   出版者・発行元：日本臨床血液学会  

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    その他リンク： http://search.jamas.or.jp/link/ui/1996161261

  • 高齢者急性非リンパ性白血病の治療成績

    藤沢 信, 丸田 壱郎, 小川 浩司, 酒井 リカ, 田口 淳, 富田 直人, 児玉 文雄, 佐々木 津, 府川 仁哉, 村田 興, 橋本 佳巳, 原野 浩, 加藤 治子, 野口 太平, 金森 平和, 宮下 裕子, 松崎 道男, 本村 茂樹, 毛利 博, 大久保 隆男

    臨床血液   36 ( 2 )   91 - 97   1995年2月

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    記述言語：日本語   出版者・発行元：日本臨床血液学会  

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    その他リンク： http://search.jamas.or.jp/link/ui/1995223158

  • Ara-C少量療法により5年以上の寛解が得られた低形成性白血病の1例

    藤沢 信, 金森 平和, 野口 太平, 丸田 壱郎, 小川 浩司, 酒井 リカ, 田口 淳, 富田 直人, 児玉 文雄, 大久保 隆男

    臨床血液   36 ( 1 )   56 - 58   1995年1月

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