Bidirectional gene organization: A common architectural feature of the human genome Reviewed

N Adachi, MR Lieber

Cell   109 ( 7 )   807 - 809   2002.6

DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair Reviewed

Noritaka Adachi, Takayuki Ishino, Yasuyuki Ishii, Shunichi Takeda, Hideki Koyama

Proc. Natl. Acad. Sci. USA   98 ( 21 )   12109 - 12113   2001.10

Sulforaphane Induces Transient Reactive Oxygen Species-Mediated DNA Damage in HeLa Cells. Reviewed International journal

Sakine Kobayashi, Seiya Nishiba, Chinatsu Sato, Kazuya Toriumi, Yuduki Someya, Noritaka Adachi, Shigeki Takeda, Aya Kurosawa

Genes to Cells   30 ( 1 )   e13190   2025.1

Quercetin exhibits cytotoxicity in cancer cells by inducing two-ended DNA double-strand breaks

Yuduki Someya, Shinta Saito, Shigeki Takeda, Noritaka Adachi, Aya Kurosawa

Biochemical and Biophysical Research Communications   739   150977 - 150977   2024.12

SMAD2/3 signaling regulates initiation of mouse Wolffian ducts and proximal differentiation in Müllerian ducts

Tadaaki Nakajima, Akihiro Imai, Chihiro Ishii, Kota Tsuruyama, Risa Yamanaka, Yasuhiro Tomooka, Shinta Saito, Noritaka Adachi, Satomi Kohno, Tomomi Sato

FEBS Open Bio   2023.11

Arsenic affects homologous recombination and single‐strand annealing but not end‐joining pathways during DNA double‐strand break repair

Aya Kurosawa, Shinta Saito, Mikiko Sakurai, Mizuki Shinozuka, Yuduki Someya, Noritaka Adachi

FEBS J.   2023.8

A Cell System-Assisted Strategy for Evaluating the Natural Antioxidant-Induced Double-Stranded DNA Break (DSB) Style. International journal

Yuduki Someya, Sakine Kobayashi, Kazuya Toriumi, Shigeki Takeda, Noritaka Adachi, Aya Kurosawa

Genes   14 ( 2 )   2023.2

Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells. Reviewed International journal

Tetsuya Suzuki, Akira Sassa, Petr Grúz, Ramesh C Gupta, Francis Johnson, Noritaka Adachi, Takehiko Nohmi

DNA Repair   100   103052 - 103052   2021.4

Correction: LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs. Reviewed International journal

Rik Schrijvers, Jan De Rijck, Jonas Demeulemeester, Noritaka Adachi, Sofie Vets, Keshet Ronen, Frauke Christ, Frederic D Bushman, Zeger Debyser, Rik Gijsbers

PLoS Pathogens   16 ( 9 )   e1008894   2020.9

Complex genetic interactions between DNA polymerase β and the NHEJ ligase. Reviewed International journal

Aya Kurosawa, Hiroyuki Kuboshima, Noritaka Adachi

FEBS J.   287 ( 2 )   377 - 385   2020.1

Reply: Radiation Dose Does Matter: Mechanistic Insights into DNA Damage and Repair Support the Linear No-Threshold Model of Low-Dose Radiation Health Risks. Reviewed

Duncan JR, Lieber MR, Adachi N, Wahl RL

Journal of Nuclear Medicine   60 ( 3 )   437 - 438   2019.3

Reply: Radiation Dose Does Matter: Mechanistic Insights into DNA Damage and Repair Support the Linear No-Threshold Model of Low-Dose Radiation Health Risks Reviewed

Duncan JR, Lieber MR, Adachi N, Wahl RL

Journal of Nuclear Medicine   59 ( 11 )   1780 - 1781   2018.11

Radiation Dose Does Matter: Mechanistic Insights into DNA Damage and Repair Support the Linear No-Threshold Model of Low-Dose Radiation Health Risks. Reviewed

Duncan JR, Lieber MR, Adachi N, Wahl RL

Journal of Nuclear Medicine   59 ( 7 )   1014 - 1016   2018.7

Dynamic behavior of DNA topoisomerase IIβ in response to DNA double-strand breaks. Reviewed

Morotomi-Yano K, Saito S, Adachi N, Yano KI

Scientific Reports   8 ( 1 )   10344   2018.7

DNA repair after exposure to ionizing radiation is not error-free Reviewed

James R. Duncan, Michael R. Lieber, Noritaka Adachi, Richard L. Wahl

Journal of Nuclear Medicine   59 ( 2 )   348   2018.2

Mechanistic basis for increased human gene targeting by promoterless vectors-roles of homology arms and Rad54 paralogs Reviewed

Shinta Saito, Aya Kurosawa, Noritaka Adachi

FEBS J.   284 ( 17 )   2748 - 2763   2017.9

TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation Reviewed

Ryo Maeda, Hiroyuki Tamashiro, Kazunori Takano, Hiro Takahashi, Hidefumi Suzuki, Shinta Saito, Waka Kojima, Noritaka Adachi, Kiyoe Ura, Takeshi Endo, Taka-aki Tamura

J. Biol. Chem.   292 ( 8 )   3201 - 3212   2017.2

DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis Reviewed

Yuki Kanemaru, Tetsuya Suzuki, Akira Sassa, Kyomu Matsumoto, Noritaka Adachi, Masamitsu Honma, Satoshi Numazawa, Takehiko Nohmi

Genes and Environment   39 ( 1 )   6   2017

Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase zeta to genotoxic stresses Reviewed

Tetsuya Suzuki, Petr Gruz, Masamitsu Honma, Noritaka Adachi, Takehiko Nohmi

DNA REPAIR   45   34 - 43   2016.9

The role of DNA polymerase zeta in translesion synthesis across bulky DNA adducts and cross-links in human cells Reviewed

Tetsuya Suzuki, Petr Gruz, Masamitsu Honma, Noritaka Adachi, Takehiko Nohmi

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS   791   35 - 41   2016.9

Mutations in XRCC4 cause primordial dwarfism without causing immunodeficiency Reviewed

Shinta Saito, Aya Kurosawa, Noritaka Adachi

JOURNAL OF HUMAN GENETICS   61 ( 8 )   679 - 685   2016.8

Advances in the Development of Gene-Targeting Vectors to Increase the Efficiency of Genetic Modification Reviewed

Shinta Saito, Noritaka Adachi

BIOLOGICAL & PHARMACEUTICAL BULLETIN   39 ( 1 )   25 - 32   2016.1

Catalytic and non-catalytic roles of DNA polymerase kappa in the protection of human cells against genotoxic stresses Reviewed

Yuki Kanemaru, Tetsuya Suzuki, Naoko Niimi, Petr Gruz, Kyomu Matsumoto, Noritaka Adachi, Masamitsu Honma, Takehiko Nohmi

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS   56 ( 8 )   650 - 662   2015.10

XRCC4遺伝子変異を原因とする遺伝性疾患:免疫不全を伴わない原発性小人症 Reviewed

SAITO SHINTA, KUROSAWA AYA, ADACHI NORITAKA

放射線生物研究   50 ( 3 )   269 - 280   2015.9

Role for Artemis nuclease in the repair of radiation-induced DNA double strand breaks by alternative end joining Reviewed

Mario Moscariello, Radi Wieloch, Aya Kurosawa, Fanghua Li, Noritaka Adachi, Emil Mladenov, George Iliakis

DNA REPAIR   31   29 - 40   2015.7

Construction and applications of exon-trapping gene-targeting vectors with a novel strategy for negative selection Biotechnology Reviewed

Shinta Saito, Kiyoe Ura, Miho Kodama, Noritaka Adachi

BMC Research Notes   8 ( 1 )   278   2015.6

In vivo protective roles of DNA polymerase kappa against genotoxic insults Reviewed

Kanemaru Yuki, Takeiri Akira, Suzuki Tetsuya, Wada Naoko A, Niimi Naoko, Gruz Petr, Motoyama Shigeki, Matsuzaki Kaori, Tateishi Hiromi, Matsumoto Kaoru, Sassa Akira, Masumura Kenichi, Yamada Masami, Mishima Masayuki, Jishage Kou-ichi, Matsumoto Kyomu, Adachi Noritaka, Honma Masamitsu, Nohmi Takehiko

DNA REPAIR   28   143   2015.4

Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells Reviewed

Takashi Ishii, Hiroshi Hayakawa, Takeshi Sekiguchi, Noritaka Adachi, Mutsuo Sekiguchi

FREE RADICAL BIOLOGY AND MEDICINE   79   109 - 116   2015.2

Analysis of the Role of Homology Arms in Gene-Targeting Vectors in Human Cells Reviewed

Ayako Ishii, Aya Kurosawa, Shinta Saito, Noritaka Adachi

PLOS ONE   9 ( 9 )   e108236   2014.9

ヒト細胞におけるDNA二本鎖切断の修復 Invited

KUROSAWA AYA, ADACHI NORITAKA

Isotope News   ( 721 )   8 - 14   2014.5

In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase kappa Reviewed

Akira Sassa, Tetsuya Suzuki, Yuki Kanemaru, Naoko Niimi, Hirofumi Fujimoto, Atsushi Katafuchi, Petr Gruz, Manabu Yasui, Ramesh C. Gupta, Francis Johnson, Toshihiro Ohta, Masamitsu Honma, Noritaka Adachi, Takehiko Nohmi

DNA REPAIR   15   21 - 28   2014.3

C-terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin Reviewed

Sicheng Liu, Xunyue Liu, Radhika Pankaj Kamdar, Rujira Wanotayan, Mukesh Kumar Sharma, Noritaka Adachi, Yoshihisa Matsumoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   439 ( 2 )   173 - 178   2013.9

DNA Ligase IV and Artemis Act Cooperatively to Suppress Homologous Recombination in Human Cells: Implications for DNA Double-Strand Break Repair Reviewed

Aya Kurosawa, Shinta Saito, Sairei So, Mitsumasa Hashimoto, Kuniyoshi Iwabuchi, Haruka Watabe, Noritaka Adachi

PLoS ONE   8 ( 8 )   e72253   2013.8

Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks Reviewed

Mari Fujita, Hiroyuki Sasanuma, Kimiyo N. Yamamoto, Hiroshi Harada, Aya Kurosawa, Noritaka Adachi, Masato Omura, Masahiro Hiraoka, Shunichi Takeda, Kouji Hirota

PLOS ONE   8 ( 4 )   e60043   2013.4

Restoration of Mismatch Repair Functions in Human Cell Line Nalm-6, Which Has High Efficiency for Gene Targeting Reviewed

Tetsuya Suzuki, Akiko Ukai, Masamitsu Honma, Noritaka Adachi, Takehiko Nohmi

PLOS ONE   8 ( 4 )   e61189   2013.4

Both CpG Methylation and Activation-Induced Deaminase Are Required for the Fragility of the Human bcl-2 Major Breakpoint Region: Implications for the Timing of the Breaks in the t(14;18) Translocation Reviewed

Xiaoping Cui, Zhengfei Lu, Aya Kurosawa, Lars Klemm, Andrew T. Bagshaw, Albert G. Tsai, Neil Gemmell, Markus Mueschen, Noritaka Adachi, Chih-Lin Hsieh, Michael R. Lieber

MOLECULAR AND CELLULAR BIOLOGY   33 ( 5 )   947 - 957   2013.3

Generation and use of genetically modified human cell lines: a promising approach for in vitro toxicology studies. Reviewed

Adachi N

J Clinic Toxicol.   3 ( 5 )   45   2013

Repair of accidental DNA double-strand breaks in the human genome and its relevance to vector DNA integration. Reviewed

Adachi N, Saito S, Kurosawa A

Gene Technology.   3   e107   2013

Endogenous factors causative of spontaneous DNA damage that leads to random integration in human cells. Reviewed

Kamekawa H, Kurosawa A, Umehara M, Toyoda E, Adachi N

Gene Technology.   2   105   2013

DNA repair and translesion DNA synthesis as possible mechanisms underlying genotoxic thresholds Reviewed

Takehiko Nohmi, Kenichi Masumura, Petr Gruz, Naomi Toyoda-Hokaiwado, Makiko Takamune, Naoko Niimi, Tetsuya Suzuki, Yuki Kanemaru, Manabu Yasui, Masami Yamada, Masamitsu Honma, Noritaka Adachi

MUTAGENESIS   27 ( 6 )   793 - 793   2012.11

The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation Reviewed

Masaoki Kohzaki, Maria Chiourea, Gwennaelle Versini, Noritaka Adachi, Shunichi Takeda, Sarantis Gagos, Thanos D. Halazonetis

CARCINOGENESIS   33 ( 6 )   1203 - 1210   2012.11

Model for MLL translocations in therapy-related leukemia involving topoisomerase II beta-mediated DNA strand breaks and gene proximity Reviewed

Ian G. Cowell, Zbyslaw Sondka, Kayleigh Smith, Ka Cheong Lee, Catriona M. Manville, Malgorzata Sidorczuk-Lesthuruge, Holly Ashlene Rance, Kay Padget, Graham Hunter Jackson, Noritaka Adachi, Caroline A. Austin

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   109 ( 23 )   8989 - 8994   2012.6

Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs Reviewed

Shruti Malu, Pablo De Ioannes, Mikhail Kozlov, Marsha Greene, Dailia Francis, Mary Hanna, Jesse Pena, Carlos R. Escalante, Aya Kurosawa, Hediye Erdjument-Bromage, Paul Tempst, Noritaka Adachi, Paolo Vezzoni, Anna Villa, Aneel K. Aggarwal, Patricia Cortes

JOURNAL OF EXPERIMENTAL MEDICINE   209 ( 5 )   955 - 963   2012.5

LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs Reviewed

Rik Schrijvers, Jan De Rijck, Jonas Demeulemeester, Noritaka Adachi, Sofie Vets, Keshet Ronen, Frauke Christ, Frederic D. Bushman, Zeger Debyser, Rik Gijsbers

PLOS PATHOGENS   8 ( 3 )   e1002558   2012.3

Impaired cell adhesion, apoptosis, and signaling in WASP gene-disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp Reviewed

Rikiya Sato, Susumu Iiizumi, Eun-Sung Kim, Fumiko Honda, Sang-Kyou Lee, Noritaka Adachi, Hideki Koyama, Shuki Mizutani, Tomohiro Morio

INTERNATIONAL JOURNAL OF HEMATOLOGY   95 ( 3 )   299 - 310   2012.3

Impaired cell adhesion, apoptosis, and signaling in WASP gene-disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp. Reviewed

Rikiya Sato, Susumu Iiizumi, Eun-Sung Kim, Fumiko Honda, Sang-Kyou Lee, Noritaka Adachi, Hideki Koyama, Shuki Mizutani, Tomohiro Morio

Int. J. Hematol.   95 ( 3 )   299 - 310   2012.3

Nucleofection-based gene targeting in human pre-B cells Reviewed

Aya Kurosawa, Shinta Saito, Mikako Mori, Noritaka Adachi

GENE   492 ( 1 )   305 - 308   2012.1

Functions and Regulation of Artemis: A Goddess in the Maintenance of Genome Integrity Reviewed

Aya Kurosawa, Noritaka Adachi

JOURNAL OF RADIATION RESEARCH   51 ( 5 )   503 - 509   2010.9

OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling Reviewed

Ken Saito, Noritaka Adachi, Hideki Koyama, Masayuki Matsushita

FEBS LETTERS   584 ( 15 )   3340 - 3347   2010.8

Chromosomal Manipulation by Site-Specific Recombinases and Fluorescent Protein-Based Vectors Reviewed

Munehiro Uemura, Youko Niwa, Naoki Kakazu, Noritaka Adachi, Kazuo Kinoshita

PLOS ONE   5 ( 3 )   e9846   2010.3

FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells. Reviewed International journal

Kenjiro Asagoshi, Keizo Tano, Paul D Chastain 2nd, Noritaka Adachi, Eiichiro Sonoda, Koji Kikuchi, Hideki Koyama, Kenji Nagata, David G Kaufman, Shunichi Takeda, Samuel H Wilson, Masami Watanabe, James A Swenberg, Jun Nakamura

Molecular cancer research : MCR   8 ( 2 )   204 - 15   2010.2

Loss of Bloom syndrome protein destabilizes human gene cluster architecture Reviewed

Michael W. Killen, Dawn M. Stults, Noritaka Adachi, Les Hanakahi, Andrew J. Pierce

HUMAN MOLECULAR GENETICS   18 ( 18 )   3417 - 3428   2009.9

Topoisomerase II alpha inhibition following DNA transfection greatly enhances random integration in a human pre-B lymphocyte cell line Reviewed

Eriko Toyoda, Aya Kurosawa, Haruna Kamekawa, Noritaka Adachi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   382 ( 3 )   492 - 496   2009.5

Heterozygous Disruption of the DNA Topoisomerase I Gene Confers Cellular Resistance to Camptothecin in Human Cells Reviewed

Eriko Toyoda, Aya Kurosawa, Michihiko Fujii, Noritaka Adachi

BIOLOGICAL & PHARMACEUTICAL BULLETIN   32 ( 4 )   724 - 727   2009.4

[FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode Reviewed

Michihiko Fujii, Noritaka Adachi, Kazuki Shikatani, Dai Ayusawa

GENES TO CELLS   14 ( 4 )   457 - 468   2009.4

[FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode

Michihiko Fujii, Noritaka Adachi, Kazuki Shikatani, Dai Ayusawa

GENES TO CELLS   14 ( 4 )   457 - 468   2009.4

Genetic Evidence That the Non-Homologous End-Joining Repair Pathway Is Involved in LINE Retrotransposition Reviewed

Jun Suzuki, Katsumi Yamaguchi, Masaki Kajikawa, Kenji Ichiyanagi, Noritaka Adachi, Hideki Koyama, Shunichi Takeda, Norihiro Okada

PLOS GENETICS   5 ( 4 )   e1000461   2009.4

Generation of tetracycline-inducible conditional gene knockout cells in a human Nalm-6 cell line Reviewed

Tatsuya Ono, Hitoshi Nishijima, Noritaka Adachi, Susumu Iizumi, Akane Morohoshi, Hideki Koyama, Kei-ichi Shibahara

JOURNAL OF BIOTECHNOLOGY   141 ( 1-2 )   1 - 7   2009.4

Molecular Mechanism of Protein Assembly on DNA Double-strand Breaks in the Non-homologous End-joining Pathway Reviewed

Ken-ichi Yano, Keiko Morotomi-Yano, Noritaka Adachi, Hidenori Akiyama

JOURNAL OF RADIATION RESEARCH   50 ( 2 )   97 - 108   2009.3

Mechanisms of chromosomal DNA strand break repair in human cells. Reviewed

Noritaka ADACHI

Tanpakushitsu Kakusan Koso.   54 ( 4 Suppl )   472 - 478   2009.3

The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase II alpha in Breast Cancer Cells Reviewed

V. Ashutosh Rao, Sarah R. Klein, Keli K. Agama, Eriko Toyoda, Noritaka Adachi, Yves Pommier, Emily B. Shacter

CANCER RESEARCH   69 ( 3 )   948 - 957   2009.2

Improved applications of the tetracycline-regulated gene depletion system Reviewed

Hitoshi Nishijima, Takami Yasunari, Tatsuo Nakayama, Noritaka Adachi, Kei-ichi Shibahara

BIOSCIENCE TRENDS   3 ( 5 )   161 - 167   2009

Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting Reviewed

Susumu Iiizumi, Aya Kurosawa, Sairei So, Yasuyuki Ishii, Yuichi Chikaraishi, Ayako Ishii, Hideki Koyama, Noritaka Adachi

NUCLEIC ACIDS RESEARCH   36 ( 19 )   6333 - 6342   2008.11

KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation Reviewed

Takuya Abe, Masamichi Ishiai, Yoshifumi Hosono, Akari Yoshimura, Shusuke Tada, Noritaka Adachi, Hideki Koyama, Minoru Takata, Shunichi Takeda, Takemi Enomoto, Masayuki Seki

CELLULAR SIGNALLING   20 ( 11 )   1978 - 1985   2008.11

Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF Reviewed

Sumithra Jayaram, Gary Ketner, Noritaka Adachi, Les A. Hanakahi

NUCLEIC ACIDS RESEARCH   36 ( 18 )   5773 - 5786   2008.10

NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform Reviewed

Eriko Toyoda, Shigehide Kagaya, Ian G. Cowell, Aya Kurosawa, Keiichi Kamoshita, Kiyohiro Nishikawa, Susumu Iiizumi, Hideki Koyama, Caroline A. Austin, Noritaka Adachi

JOURNAL OF BIOLOGICAL CHEMISTRY   283 ( 35 )   23711 - 23720   2008.8

Cell sorting analysis of cell cycle-dependent X-ray sensitivity in end joining-deficient human cells Reviewed

Kuniyoshi Iwabuchi, Mitsumasa Hashimoto, Tadashi Matsui, Aya Kurosawa, Noritaka Adachi, Takayasu Date

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   372 ( 4 )   662 - 667   2008.8

The requirement of artemis in double-strand break repair depends on the type of DNA damage Reviewed

Aya Kurosawa, Hideki Koyama, Shinichi Takayama, Kensuke Miki, Dai Ayusawa, Michihiko Fujii, Susumu Iiizumi, Noritaka Adachi

DNA AND CELL BIOLOGY   27 ( 1 )   55 - 61   2008.1

Gene targeting in cultured human cells Reviewed

Susumu Iiizumi, Noritaka Adachi

Seikagaku   80 ( 7 )   651 - 657   2008

Highly proficient gene targeting by homologous recombination in the human Pre-B cell line Nalm-6 Reviewed

Noritaka Adachi, Aya Kurosawa, Hideki Koyama

Methods in Molecular Biology   435   17 - 29   2008

Gene targeting using the human Nalm-6 pre-B cell line Reviewed

Noritaka Adachi, Hitoshi Nishijima, Kei-Ichi Shibahara

BIOSCIENCE TRENDS   2 ( 5 )   169 - 180   2008

Overexpression of HAM1 gene detoxifies 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae

Shinichi Takayama, Michihiko Fujii, Aya Kurosawa, Noritaka Adachi, Dai Ayusawa

CURRENT GENETICS   52 ( 5-6 )   203 - 211   2007.11

Overexpression of HAM1 gene detoxifies 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae Reviewed

Shinichi Takayama, Michihiko Fujii, Aya Kurosawa, Noritaka Adachi, Dai Ayusawa

CURRENT GENETICS   52 ( 5-6 )   203 - 211   2007.11

MK314は安定したDNA切断複合体を形成するトポイソメラーゼIIα特異的阻害剤である(NK314 is a topoisomerase IIα specific inhibitorforming stable DNA cleavage complex)

豊田 恵利子, 加々谷 重英, 岡本 一也, 横山 浩史, 長幡 武光, 西川 清広, 黒沢 綾, 小山 秀機, 足立 典隆

日本癌学会総会記事   66回   204 - 205   2007.8

遺伝性癌の分子遺伝学と疫学 ヒト遺伝子ノックアウト細胞株を用いたトポイソメラーゼ介在性DNA損傷の修復に関する遺伝的研究(Molecular Genetics and Epidemiology of Hereditary Cancer Genetic studies on the repair of topoisomerase-mediated DNA damage using human gene knockout cell lines)

黒沢 綾, 豊田 恵利子, 小山 秀機, 足立 典隆

日本癌学会総会記事   66回   258 - 258   2007.8

Absence of p53 enhances growth defects and etoposide sensitivity of human cells lacking the bloom syndrome helicase BLM Reviewed

Sairei So, Noritaka Adachi, Hideki Koyama

DNA AND CELL BIOLOGY   26 ( 7 )   517 - 525   2007.7

ヒト重症複合型免疫不全症候群原因遺伝子ARTEMISの機能と制御

足立 典隆

放射線生物研究   印刷中 ( 4 )   386 - 401   2007

Simple one-week method to construct gene-targeting vectors: application to production of human knockout cell lines Reviewed

Susumu Iiizumi, Yuji Nomura, Sairei So, Koichi Uegaki, Kayoko Aoki, Kei-ichi Shibahara, Noritaka Adachi, Hideki Koyama

BIOTECHNIQUES   41 ( 3 )   311 - +   2006.9

53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis Reviewed

Kuniyoshi Iwabuchi, Mitsumasa Hashimoto, Tadashi Matsui, Takayuki Kurihara, Hiroko Shimizu, Noritaka Adachi, Masamichi Ishiai, Ken-ichi Yamamoto, Hiroshi Tauchi, Minoru Takata, Hideki Koyama, Takayasu Date

GENES TO CELLS   11 ( 8 )   935 - 948   2006.8

Enhanced gene targeting efficiency by siRNA that silences the expression of the Bloom syndrome gene in human cells Reviewed

S So, Y Nomura, N Adachi, Y Kobayashi, T Hori, Y Kurihara, H Koyama

GENES TO CELLS   11 ( 4 )   363 - 371   2006.4

Heterozygous inactivation ofhuman Ku70/Ku86 heterodimer does not affect cell growth, double-strand break repair, or genome integrity Reviewed

K Uegaki, N Adachi, S So, S Iiizumi, H Koyama

DNA REPAIR   5 ( 3 )   303 - 311   2006.3

Parp-1 protects homologous recombination from interference by Ku and ligase IV in vertebrate cells Reviewed

H Hochegger, D Dejsuphong, T Fukushima, C Morrison, E Sonoda, Schreiber, V, GY Zhao, A Saberi, M Masutani, N Adachi, H Koyama, G de Murcia, S Takeda

EMBO JOURNAL   25 ( 6 )   1305 - 1314   2006.3

The human pre-B cell line Nalm-6 is highly proficient in gene targeting by homologous recombination Reviewed

N Adachi, S So, S Iiizumi, Y Nomura, K Murai, C Yamakawa, K Miyagawa, H Koyama

DNA AND CELL BIOLOGY   25 ( 1 )   19 - 24   2006.1

DNA二重鎖切断修復の新守護神

足立 典隆

実験医学   24   2006

Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends Reviewed

K Kikuchi, Y Taniguchi, A Hatanaka, E Sonoda, H Hochegger, N Adachi, Y Matsuzaki, H Koyama, DC van Gent, M Jasin, S Takeda

MOLECULAR AND CELLULAR BIOLOGY   25 ( 16 )   6948 - 6955   2005.8

Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediated DNA damage Reviewed

N Adachi, S Iiizumi, H Koyama

DNA AND CELL BIOLOGY   24 ( 6 )   388 - 393   2005.6

Chromosomal instability in the cattle clones derived by somatic cell nuclear-transfer Reviewed

H Hanada, K Takeda, T Tagami, K Nirasawa, S Akagi, N Adachi, S Takahashi, Y Izaike, M Iwamoto, DI Fuchimoto, N Miyashita, M Kubo, A Onishi, WA King

MOLECULAR REPRODUCTION AND DEVELOPMENT   71 ( 1 )   36 - 44   2005.5

Generation and characterization of endonuclease G null mice Reviewed

RA Irvine, N Adachi, DK Shibata, GD Cassell, KF Yu, ZE Karanjawala, CL Hsieh, MR Lieber

MOLECULAR AND CELLULAR BIOLOGY   25 ( 1 )   294 - 302   2005.1

Genetic interactions between BLM and DNA ligase IV in human cells Reviewed

S So, N Adachi, MR Lieber, H Koyama

JOURNAL OF BIOLOGICAL CHEMISTRY   279 ( 53 )   55433 - 55442   2004.12

Loss of nonhomologous end joining confers camptothecin resistance in DT40 cells - Implications for the repair of topoisomerase I-mediated DNA damage Reviewed

N Adachi, So, SR, H Koyama

JOURNAL OF BIOLOGICAL CHEMISTRY   279 ( 36 )   37343 - 37348   2004.9

Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage Reviewed

N Adachi, S Iiizumi, S So, H Koyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   318 ( 4 )   856 - 861   2004.6

Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193 - Implications for the repair of topoisomerase II-mediated DNA damage Reviewed

N Adachi, H Suzuki, S Iiizumi, H Koyama

JOURNAL OF BIOLOGICAL CHEMISTRY   278 ( 38 )   35897 - 35902   2003.9

Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase II alpha Reviewed

N Akimitsu, N Adachi, H Hirai, MS Hossain, H Hamamoto, M Kobayashi, Y Aratani, H Koyama, K Sekimizu

GENES TO CELLS   8 ( 4 )   393 - 402   2003.4

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants Reviewed

ZE Karanjawala, N Adachi, RA Irvine, EK Oh, D Shibata, K Schwarz, CL Hsieh, MR Lieber

DNA REPAIR   1 ( 12 )   1017 - 1026   2002.12

Vertebrate cells lacking FEN-1 endonuclease are viable but hypersensitive to methylating agents and H2O2 Reviewed

Y Matsuzaki, N Adachi, H Koyama

NUCLEIC ACIDS RESEARCH   30 ( 14 )   3273 - 3277   2002.7

5-bromo-2 '-deoxyuridine efficiently suppresses division potential of the yeast Saccharomyces cerevisiae Reviewed

M Fujii, H Ito, T Hasegawa, T Suzuki, N Adachi, D Ayusawa

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   66 ( 4 )   906 - 909   2002.4

Two overlapping divergent transcription units in the human genome: The FEN1/C11orf10 locus Reviewed

Noritaka Adachi, Zarir E. Karanjawala, Yasuo Matsuzaki, Hideki Koyama, Michael R. Lieber

OMICS A Journal of Integrative Biology   6 ( 3 )   273 - 279   2002

Decreased topoisomerase IIα expression confers increased resistance to ICRF-193 as well as VP-16 in mouse embryonic stem cells Reviewed

Masao Kobayashi, Noritaka Adachi, Yasuaki Aratani, Akihiko Kikuchi, Hideki Koyama

Cancer Letters   166 ( 1 )   71 - 77   2001.5

Bleomycin enhances random integration of transfected DNA into a human genome Reviewed

Chikako Nakayama, Noritaka Adachi, Hideki Koyama

Mutation Research - DNA Repair   409 ( 1 )   1 - 10   1998.10

Characterization of the 3' untranslated region of mouse DNA topoisomerase IIα mRNA Reviewed

Masao Kobayashi, Noritaka Adachi, Hideki Koyama

Gene   215 ( 2 )   329 - 337   1998.7

Cell cycle-dependent regulation of the mouse DNA topoisomerase IIα gene promoter Reviewed

Noritaka Adachi, Masao Kobayashi, Hideki Koyama

Biochemical and Biophysical Research Communications   230 ( 1 )   105 - 109   1997.1

Functional analysis of human WHSC1 in DNA double-strand break repair

坂本裕太, 斎藤慎太, 足立典隆

日本環境変異原学会大会プログラム・要旨集   49th (CD-ROM)   2020

ヒト二本鎖DNA切断修復機構とゲノム安定性維持

足立 典隆

上原記念生命科学財団研究報告集   33   1 - 5   2019.12

ベクターDNAの非特異的な組込みを100%抑制する

足立 典隆

Medical Science Digest   45 ( 9 )   560 - 562   2019.8

ヒト細胞におけるDNAポリメラーゼθの機能解析

吉川真子, 斎藤慎太, 足立典隆

日本分子生物学会年会プログラム・要旨集(Web)   42nd   2019

DNA二本鎖切断修復におけるAPOBEC3Gの役割

門口美咲, 斎藤慎太, 斎藤慎太, 村山美織, 足立典隆, 足立典隆

日本分子生物学会年会プログラム・要旨集(Web)   42nd   2019

二重鎖切断修復および外来DNA組み込みにおけるヒトDNA polymerase θの役割(Role of human DNA polymerase θ in double-strand break repair and foreign DNA integration)

斎藤 慎太, 足立 典隆

日本癌学会総会記事   77回   1289 - 1289   2018.9

ヒストンメチル化酵素NSD2とDNA損傷修復

原田佳歩, 佐々彰, 竹内心, 足立典隆, 浦聖恵

日本環境変異原学会大会プログラム・要旨集   47th   2018

ヒストンメチル化酵素NSD2のDNA損傷修復への関与の解明

原田佳歩, 佐々彰, 鈴木慈, 前田亮, 足立典隆, 浦聖恵

日本分子生物学会年会プログラム・要旨集(Web)   41st   2018

エトポシドにより促進されるランダムインテグレーションのメカニズムの解析

森本 精太, 斎藤 慎太, 足立 典隆

生命科学系学会合同年次大会   2017年度   [1P - 0723]   2017.12

DNA二本鎖切断修復におけるDNAポリメラーゼθの機能解析

吉川 真子, 斎藤 慎太, 足立 典隆

生命科学系学会合同年次大会   2017年度   [1P - 0720]   2017.12

ヒストンH3K36メチル化酵素NSD2を介したゲノム維持機構の解析

鈴木 慈, 原田 佳歩, 佐々 彰, 福戸 敦彦, 田代 聡, 足立 典隆, 浦 聖恵

生命科学系学会合同年次大会   2017年度   [2P - 0588]   2017.12

DNAポリメラーゼθは異なる末端の接続に必須である(DNA polymerise θis essential for alternative end-joining)

斎藤 慎太, 足立 典隆

生命科学系学会合同年次大会   2017年度   [4LT16 - 0595)]   2017.12

二重鎖DNA切断修復と外部DNA統合におけるヒトDNAポリメラーゼθの役割(Role of human DNA polymerise θ in double-strand break repair and foreign DNA integration)

斎藤 慎太, 足立 典隆

日本癌学会総会記事   76回   P - 2013   2017.9

ヒトiPS細胞を用いた遺伝子ターゲティングの効率化

阿部 雄太, 斎藤 慎太, 足立 典隆

日本薬学会年会要旨集   136年会 ( 3 )   122 - 122   2016.3

DNA二本鎖切断修復におけるヒトWHSC1遺伝子の機能解析

小川敬史, 斎藤慎太, 足立典隆, 足立典隆

日本分子生物学会年会プログラム・要旨集(Web)   39th   2016

ヒトDNA二本鎖切断修復におけるXRCC4とLIG4の機能解析

山下顕裕, 斎藤慎太, 内田夏海, 足立典隆, 足立典隆

日本分子生物学会年会プログラム・要旨集(Web)   39th   2016

DNA二重鎖切断修復におけるヒトのDNA-PKcsの調節的な役割(Regulatory role of human DNA-PKcs in DNA double-strand break repair)

渡部 瑶, 斎藤 慎太, 黒沢 綾, 足立 典隆

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回   [3LBA029] - [3LBA029]   2015.12

ヒト体細胞における高効率の遺伝子標的化システムの開発 ベクターの染色体への統合のメカニズム解析(Development of a high-efficiency gene-targeting system in human somatic cells: mechanistic analysis of vector integration)

斎藤 慎太, 足立 典隆

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回   [3LBA030] - [3LBA030]   2015.12

Protective Roles of DNA Polymerase Zeta in Human Cells Against Environmental Genotoxins.

T. Suzuki, P. Gruz, M. Honma, N. Adachi, T. Nohmi

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS   56   S59 - S59   2015.8

放射線によって誘導されるDNAの複製異常に対してはBLMヘリカーゼではなくRecQL4ヘリカーゼが重要な働きをする(Human RecQL4, but not BLM, helicase facilitate replication elongation on DNA templates damaged by ionizing radiation)

香崎 正宙, 足立 典隆, 武田 俊一

日本癌学会総会記事   73回   P - 3002   2014.9

ヒト遺伝子ノックアウト細胞を用いたDNA ligase IV/XRCC4複合体の機能解析

内田夏海, 斎藤慎太, 足立典隆, 足立典隆

日本薬学会年会要旨集(CD-ROM)   134th   2014

DNA polymerase kappaのヒトゲノム恒常性維持における構造的および触媒的役割の検討

兼丸祐紀, 鈴木哲矢, 新見直子, GRUZ Petr, 松元郷六, 足立典隆, 本間正充, 能美健彦

日本分子生物学会年会プログラム・要旨集(Web)   37th   1P-0183 (WEB ONLY)   2014

Phenylalanine 171 of Human DNA Polymerase Kappa Is a Molecular Brake for Translesion DNA Synthesis across Benzo[a]pyrene Adducts.

A. Sassa, T. Suzuki, Y. Kanemaru, N. Niimi, H. Fujimoto, A. Katafuchi, P. Gruz, M. Yasui, R. Gupta, F. Johnson, T. Ohta, M. Honma, N. Adachi, T. Nohmi

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS   54   S31 - S31   2013.9

酸化RNAに結合するタンパク質AUF1の働き:遺伝子ノックアウト細胞の作製と解析

石井健士, 早川浩, 関口猛, 足立典隆, 関口睦夫

日本分子生物学会年会プログラム・要旨集(Web)   36th   2013

生化学的分画法によるXRCC4-DNAリガーゼIV複合体のクロマチン結合の解析(Chromatin binding of XRCC4-DNA ligase IV complex revealed by biochemical fractionation analysis)

Liu Sicheng, Kamdar Radhika Pankaj, 足立 典隆, 松本 義久

日本放射線影響学会大会講演要旨集   55回   117 - 117   2012.9

低線量率放射線照射下におけるDNA2重鎖切断修復因子の役割

冨田雅典, 小林純也, 岩淵邦芳, 松本義久, 足立典隆, 高田穣, 内海博司

日本放射線影響学会大会講演要旨集   55th   2012

損傷を誘発する化学物質の細胞毒性に対するヒトDNAポリメラーゼζの役割

鈴木哲矢, 足立典隆, 能美健彦, 能美健彦

日本分子生物学会年会プログラム・要旨集(Web)   35th   2012

RecQL4のヘリカーゼドメインを含むC末部位はヒトにおいて放射線によるDNAダメージ損傷後のDNA複製伸長を促進する

香崎正宙, CHIOUREA Maria, VERSINI Gwennaelle, 足立典隆, 武田俊一, GAGOS Sarantis, HALAZONETIS Thanos D.

日本分子生物学会年会プログラム・要旨集(Web)   35th   2012

P-089 Evaluation of genotoxic and cytotoxic sensitivity of DNA polymerase κ knockout and knockin human cells to DNA damaging agents(Poster Presentation)

Kanemaru Yuki, Suzuki Tetsuya, Niimi Naoko, Gruz Petr, Matsumoto Kyomu, Adachi Noritaka, Honma Masamitsu, Nohmi Takehiko

日本環境変異原学会大会プログラム・要旨集   ( 40 )   137 - 137   2011

ヒト細胞における遺伝子標的効率の改善(Improvement of gene-targeting efficiency in human cells)

黒沢 綾, 足立 典隆

日本癌学会総会記事   69回   117 - 117   2010.8

High-efficiency gene targeting in a human pre-B cell line: towards the human gene knockout project

Noritaka Adachi

GENOME BIOLOGY   11   2010

Cre組換え酵素による染色体間組換え頻度測定により明らかとなったテロメア近傍遺伝子のアクセシビリティー

植村宗弘, 丹羽陽子, 嘉数直樹, 足立典隆, 木下和生

生化学   2010

P-007 Characterization of human DNA polymerase κ(Poster Session)

Niimi Naoko, Iiizumi Susumu, Adachi Noritaka, Koyama Hideki, Nohmi Takehiko

日本環境変異原学会大会プログラム・要旨集   ( 37 )   110 - 110   2008

Genetic analysis of an interaction between human Mus81 and cross-link repair factors

NOMURA YUJI, ADACHI NORITAKA, SO SAIREI, AOKI KAYOKO, KOYAMA HIDEKI

25 ( 1 )   73 - 73   2006.3

Gene knockout studies on DNA strand break repair in human cells

ADACHI NORITAKA, IIIZUMI SUSUMU, NOMURA YUJI, SO SAIREI, KOYAMA HIDEAKI

25 ( 1 )   72 - 72   2006.3

High-efficiency gene targeting with BLM siRNA in human cell lines

SO SAIREI, NOMURA YUJI, ADACHI NORITAKA, IIIZUMI SUSUMU, KOBAYASHI YUKI, HORI TAMAKI, KURIHARA HARUYUKI, KOYAMA HIDEKI

25 ( 1 )   74 - 74   2006.3

Impact of DNA ligase IV deficiency on random and targeted integration

IIIZUMI SUSUMU, ADACHI NORITAKA, ISHII YASUYUKI, CHIKARAISHI YUICHI, SO SAIREI, KOYAMA HIDEKI

25 ( 1 )   71 - 71   2006.3

ゲノムDNA鎖切断の修復における二本鎖切断修復経路の役割

足立 典隆, 小山 秀機

放射線生物研究   39 ( 3 )   231 - 243   2004.9

Analysis of Genomic Instability and DNA Double-strand Break Repair in Human BLM Knockout Cells

SO Sairei, ADACHI Noritaka, LIEBER Michael R, KOYAMA Hideki

23 ( 1 )   44 - 44   2004.3

O6-2 Repair efficiency of DNA single strand breaks in base excision repair deficient cells as determined by a real-time strand break assay.

Buersutatte A-M.

( 33 )   118 - 118   2004

DNA複製関連酵素の変異体作製による,in vivo及びin vitroでの酵素機能解析 哺乳動物細胞のS期開始におけるDNAトポイソメラーゼIIαの役割

関水 和久, 秋光 信佳, シャヒッドホサイン・ムクタディール, 濱本 洋, 足立 典隆, 小林 正男, 荒谷 康昭, 小山 秀機, 高木 亨, 平井 洋

生化学   73 ( 8 )   650 - 650   2001.8

Analysis on the mechanism of DNA topoisomerase IIα gene expression

ADACHI Noritaka, NOMOTO Minoru, KOYAMA Hideki

21   407 - 407   1998.12

トポイソメラ-ゼの発現制御機構と変異株を利用した機能解析 (特集 DNAトポロジ---細胞生物学へ踏み込むトポイソメラ-ゼ)

足立 典隆, 小林 正男, 小山 秀機

細胞工学   16 ( 11 )   1597 - 1605   1997.11

Enhancement by Bleomycin of Nonhomologous Recombination in Human Cells

NAKAYAMA C., ADACHI N., KOYAMA H.

16 ( 1 )   80 - 80   1997.3

マウスDNAトポイソメラーゼIIα遺伝子の構造と発現

足立 典隆, 小林 正男, 小山 秀機

日本分子生物学会年会プログラム・講演要旨集   19   434 - 434   1996.8

細胞増殖におけるDNAトポイソメラーゼIIαの必須性の検討

小林 正男, 足立 典隆, 小山 秀機

日本分子生物学会年会プログラム・講演要旨集   19   294 - 294   1996.8

The Int'l Symp. on DNA Topoisomerases in Chemotherapy

ADACHI NORITAKA

Farumashia   28 ( 3 )   280 - 280   1992.3

Role of DNA-PKcs in neurogenesis

Grant number：26740019  2014.4 - 2016.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

Kurosawa Aya, ADACHI Noritaka

Development and applications of high-efficiency gene targeting in human cells

Grant number：24310149  2012.4 - 2015.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

ADACHI NORITAKA

Analysis of human genes that enable high-efficiency gene targeting

Grant number：24659035  2012.4 - 2014.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

ADACHI Noritaka

ゲノム切断修復におけるクロマチン構造の役割

Grant number：23131511  2011.4 - 2013.3

日本学術振興会  科学研究費助成事業  新学術領域研究(研究領域提案型)

足立 典隆

Epigenetic marking by histone variant H3.3 during myeloid cell differentiation

Grant number：23659492  2011 - 2012

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

TAMURA Tomohiko, ADACHI Noritaka, NISHIYAMA Akira

GeneticanalysisofDNAstrandbreakrepairinhumancelIs

Grant number：21590066  2009 - 2011

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

ADACHI Noritaka

ヒト遺伝子ノックアウトシステムの効率化と疾患遺伝子機能解析への応用

Grant number：20018022  2008 - 2009

日本学術振興会  科学研究費助成事業  特定領域研究

足立 典隆

ヒト染色体DNA切断とその修復機構

Grant number：20055017  2008 - 2009

日本学術振興会  科学研究費助成事業  特定領域研究

足立 典隆

ヒトDNA鎖切断修復の逆遺伝学的解析と医療への応用

Grant number：18018034  2006 - 2007

日本学術振興会  科学研究費助成事業  特定領域研究

足立 典隆, 小山 秀機

Analysis of DNA strand break repair using human knockout cells

Grant number：18590063  2006 - 2007

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

ADACHI Noritaka

Genetic studies on the interaction between base excision repair and recombinational repair using human gene knockout cells

Grant number：18570163  2006 - 2007

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

KOYAMA Hideki, ADACHI Noritaka

ヒト染色体DNA切断とその修復機構

Grant number：18058019  2006 - 2007

日本学術振興会  科学研究費助成事業  特定領域研究

足立 典隆, 小山 秀機

動物細胞のDNA鎖切断修復と非相同組換えに関する逆遺伝学的解析

Grant number：16790058  2004 - 2005

日本学術振興会  科学研究費助成事業  若手研究(B)

足立 典隆

トポイソメラーゼ阻害剤によるゲノム損傷の修復におけるDNA鎖切断修復機構の役割

Grant number：16023257  2004

日本学術振興会  科学研究費助成事業  特定領域研究

足立 典隆

ヒト遺伝子の系統的な機能解析に向けた高効率ジーンターゲティング系の開発

Grant number：16012252  2004

日本学術振興会  科学研究費助成事業  特定領域研究

小山 秀機, 足立 典隆

ヒトプレB細胞よりBLM破壊株の作製とその非相同組換え能の解析

Grant number：16021247  2004

日本学術振興会  科学研究費助成事業  特定領域研究

小山 秀機, 足立 典隆

Studies of base excision repair in cell mutants deficient. in either DNA polymerase, or flap endonuclease-1 or both, generated from chicken DT40 cells.

Grant number：15570146  2003 - 2004

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

KOYAMA Hideki, ADACHI Noritaka

ヒトプレB細胞よりBLM破壊株の作製とそ非相同的末端連結能の解析

Grant number：15023249  2003

日本学術振興会  科学研究費助成事業  特定領域研究

小山 秀機, 足立 典隆

DT40細胞を用いた非相同組換え機構の遺伝的解析

Grant number：14771289  2002 - 2003

日本学術振興会  科学研究費助成事業  若手研究(B)

足立 典隆

ニワトリDT40細胞を用いた非相同組換え機構の遺伝的解析

Grant number：12771409  2000 - 2001

日本学術振興会  科学研究費助成事業  奨励研究(A)

足立 典隆

DNAトポイソメラーゼIIαの生理的機能と発現制御機構

Grant number：10771295  1998 - 1999

日本学術振興会  科学研究費助成事業  奨励研究(A)

足立 典隆